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Patricia Johansson, Ludger Klein-Hitpass, Florian Grabellus, Georg Arnold, Wolfram Klapper, Roman Pförtner, Ulrich Dührsen, Anja Eckstein, Jan Dürig, Ralf Küppers
The pathogenesis of ocular adnexal marginal zone lymphomas of mucosa-associated lymphatic tissue-type (OAML) is still poorly understood. We analyzed 63 cases of such lymphomas for non-synonymous mutations in 24 candidate genes by amplicon sequencing. We validated frequent mutations in the NF-κB regulators MYD88, TNFAIP3 and TNIP1 in OAML, but also identified recurrent mutations in several additional components of the NF-κB pathway, including BCL10 and NFKBIA. Overall, 60% of cases had mutations in at least one component of NF-κB signaling, pointing to a central role of its genetic deregulation in OAML pathogenesis...
August 23, 2016: Oncotarget
Su Kyung Jung, Ji Sun Paik, Seung-Eun Jung, Gyeongsin Park, Byung-Ock Choi, Jin Kyoung Oh, Yong Gyu Park, Suk Woo Yang, Seok-Goo Cho
Ocular adnexal mucosa-associated lymphoid tissue lymphoma (OAML) has been recognized as most common primary orbital malignancy. However, little was known about the response criteria for OAML. Our aim was to suggest response criteria for nonconjunctival OAML; the response evaluation of which using the conventional response criteria is inappropriate. A retrospective chart review of 34 eyes from 30 patients diagnosed with nonconjunctival OAML was conducted, focusing on the change in tumor size based on linear bi-dimensional and three-dimensional methods in magnetic resonance imaging (MRI) of the orbit...
July 2015: Annals of Hematology
Sonay İncesoy-Özdemir, Nazmiye Yüksek, Ceyhun Bozkurt, Gürses Şahin, Leyla Memiş, Ayşen Dizman, Ulya Ertem
Primary ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphomas (OAMLs) are mostly seen in the 5th-7th decades of life, with female predominance, and they occur rarely in children. Thus, knowledge about this cancer type is obtained from adult data in the literature, while the data regarding OAMLs in the pediatric population are limited to a few case reports. Herein, we report a 10-year-old boy with OAML who was treated successfully with radiotherapy, and we discuss this uncommon lymphoma in children...
May 2014: Turkish Journal of Pediatrics
Barbara Kiesewetter, Julius Lukas, Andreas Kuchar, Marius E Mayerhoefer, Berthold Streubel, Heimo Lagler, Leonhard Müllauer, Stefan Wöhrer, Julia Fischbach, Markus Raderer
BACKGROUND: Orbital marginal zone B-cell lymphoma (OAML) constitutes for the most frequent diagnosis in orbital lymphoma. Relatively little data, however, have been reported in larger cohorts of patients staged in a uniform way and no therapy standard exists to date. MATERIAL AND METHODS: We have retrospectively analyzed 60 patients diagnosed and treated at our institution 1999-2012. Median age at diagnosis was 64 years (IQR 51-75) and follow-up time 43 months (IQR 16-92)...
2014: PloS One
M Smiljanic, R Milosevic, D Antic, B Andjelic, V Djurasinovic, M Todorovic, J Bila, A Bogdanovic, B Mihaljevic
Orbital and ocular andexal Mucosa-Associated Lymphoid Tissue Lymphoma (MALT) or ocular adnexal MALT lymphoma (OAML) is the most common of all eye non-Hodgkin lymphomas. Autoimmune inflammatory disorders and chronic infections are important etiological factors and CD5 and CD43 (sialophorin) tumor markers are significant negative prognostic factors. Disease signs and symptoms can occur a long time before diagnosis. Varieties of treatment options are available. The aim of this retrospective analysis was to compare the efficiency of different treatment options and to investigate disease outcome...
December 2013: Medical Oncology
Won-Kyung Cho, Sung-Eun Lee, Ji-Sun Paik, Seok-Goo Cho, Suk-Woo Yang
PURPOSE: To elucidate risk potentiality of frontline radiotherapy associated cataracts in primary ocular adnexal mucosa-associated lymphoid tissue lymphoma (OAML). METHODS: Data from eight consecutive patients of 41 total OAML patients who had undergone cataract surgery after frontline radiotherapy were analyzed. RESULTS: The median patient age was 46 years (range, 36 to 69 years). The median total radiation dose was 3,780 cGy (range, 3,060 to 4,500 cGy), and the mean duration from radiation irradiation to cataract surgery was 36...
August 2013: Korean Journal of Ophthalmology: KJO
Barbara Kiesewetter, Markus Raderer
Although antibiotic therapy has been established as the standard of care in patients with gastric mucosa-associated lymphoid tissue (MALT) lymphoma, much less is known about the value of antibiotic therapy in nongastrointestinal (non-GI) MALT lymphomas. A computerized search (Medline) accompanied by a manual search to identify clinical reports on the topic of antibacterial therapy in patients with non-GI MALT lymphomas was performed. The majority of data were available for MALT lymphoma of the ocular adnexa (OAML) including a total of 131 patients in 4 retrospective studies, 3 prospective series (including 81 patients), and 1 case report...
August 22, 2013: Blood
Feng Ning, Jin Ye, Li-qiang Wei, Xin Li, Jing-wen Wang
OBJECTIVE: To evaluate the clinical features, therapies and prognosis in patients with mucosa-associated lymphoid tissue (MALT) lymphoma in ocular adnexal marginal zone (OAML). METHODS: A retrospective analysis was made upon clinical data from 21 patients with OAML admitted into Beijing Tongren Hospital from June, 2008 to December, 2011. RESULTS: There were 12 (57.1%) men and 9 (42.9%) women, with a median age of 57 (23 - 79) years old. Majority of patients had localized pathological changes...
October 2012: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
Francesca Collina, Anna De Chiara, Amalia De Renzo, Gaetano De Rosa, Gerardo Botti, Renato Franco
Ocular adnexa MALT-lymphomas represent approximatively 5-15% of all extranodal lymphomas. Almost 75% of OAMLs are localized in orbital fat, while 25% of cases involves conjunctive. MALT-lymphomas often recognize specific environmental factors responsible of lymphoma development and progression. In particular as Helicobacter pylori in gastric MALT lymphomas, other bacterial infections have been recognized related to MALT lymphomas in specific site. Recently Chlamydia psittaci has been identified in Ocular Adnexa MALT lymphomas, with variable frequence dependently from geographic areas...
2012: Infectious Agents and Cancer
Ki Hwan Kim, Tae Min Kim, Heounjeong Go, Wook Youn Kim, Yoon Kyung Jeon, Se-Hoon Lee, Dong-Wan Kim, Sang In Khwarg, Chul-Woo Kim, Dae Seog Heo
We evaluated the association between tumor-infiltrating FOXP3+ T cells and clinical outcomes in patients with ocular adnexal lymphoma of mucosa-associated lymphoid tissue type (OAML). Pretreatment formalin-fixed paraffin-embedded tissues from 42 patients with OAML were stained with 236A/E7 anti-FOXP3 murine monoclonal antibody as well as CD3, CD4 and CD8 antibodies. The amount of FOXP3+ T cells was numerically quantified using an image analysis program. Front-line treatments were as follows: combination chemotherapy (n = 25); radiotherapy (n = 9); doxycycline (n = 6); and wait and see (n = 2)...
November 2011: Cancer Science
Sung-Eun Lee, Ji-Sun Paik, Won-Kyung Cho, Byung-Ock Choi, Sang-Nam Lee, Seung-Eun Jung, Kyung-Sin Park, Chang-Suk Kang, Sung-Hoon Kim, Suk-Woo Yang, Seok-Goo Cho
The American Joint Committee on Cancer has proposed the tumor, node, metastasis (TNM) staging system to overcome the limitations of the Ann Arbor staging system for ocular adnexal lymphoma. We performed this study to evaluate the feasibility of the TNM staging system for ocular adnexal extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (OAML). The data form 66 total eyes from 54 patients with biopsy-confirmed OAML according to World Health Organization classification were retrospectively analyzed...
March 2011: American Journal of Hematology
Emel Canbay, Bedia Agachan, Tulin Ozturk, Murat Giris, Oktar Asoglu, Emre Balik, Dursun Bugra
BACKGROUND: The authors aimed to investigate the effects of montelukast (ML) on the experimental rat colon anastomosis. METHODS: A total of 80 Wistar albino rats were divided into 4 groups: sham-operated, colon anastomosis, and colon anastomosis with oral administration (OAML) and rectal administration of 10 mg/kg/d ML (RAML). Anastomotic bursting pressure, anastomotic hydroxyproline contents, malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GPX), and superoxide dismutase (SOD) levels, and the expressions of Ki-67, vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF) with immunohistochemistry were assessed on postoperative day 5...
September 2010: Surgical Innovation
Tae Min Kim, Ki Hwan Kim, Min Joung Lee, Yoon Kyung Jeon, Se-Hoon Lee, Dong-Wan Kim, Chul Woo Kim, Il Han Kim, Sang In Khwarg, Dae Seog Heo
This retrospective study was launched to evaluate the efficacy of doxycycline and to find independent predictors of a clinical response in patients with ocular adnexal lymphoma of mucosa-associated lymphoid tissue (OAML). Thirty-eight patients with newly diagnosed, localized OAML received doxycycline for 3 weeks (12 patients) or 6 weeks (26 patients). Clinical factors including absolute lymphocyte count (ALC) and neutrophil count (ANC) were compared between responders and non-responders. After a median follow-up of 26...
May 2010: Cancer Science
Andrés J M Ferreri, Riccardo Dolcetti, Giuseppina P Dognini, Lucia Malabarba, Nadia Vicari, Elisa Pasini, Maurilio Ponzoni, Maria Giulia Cangi, Lorenza Pecciarini, Antonio Giordano Resti, Claudio Doglioni, Silvano Rossini, Simone Magnino
Ocular adnexal MALT lymphoma (OAML) is linked to Chlamydophila psittaci (Cp) infection. Viability and infectivity of Cp, demonstrated by growth in culture, has not been yet investigated in these patients. We conducted a single-center prospective case-control study to assess the prevalence, viability and infectivity of Cp in 20 OAML patients and 42 blood donors registered in a 6-month period. The presence of Cp in conjunctival swabs and peripheral blood mononuclear cells (PBMC) of patients and donors was assessed by TETR-PCR and in vitro cultures...
September 1, 2008: International Journal of Cancer. Journal International du Cancer
A J M Ferreri, R Dolcetti, M-Q Du, C Doglioni, A Giordano Resti, L S Politi, C De Conciliis, J Radford, F Bertoni, E Zucca, F Cavalli, M Ponzoni
Non-Hodgkin's lymphomas constitute one half of malignancies arising in the orbit and the ocular adnexae. Mucosa-associated lymphoid tissue (MALT)-type lymphoma is the most common histological category in this anatomic region. The incidence of ocular adnexal lymphoma of mucosa-associated lymphoid tissue-type (OAML) is increasing and recent studies offered new relevant insights in molecular, pathogenetic and therapeutic issues on these neoplasms. A pathogenetic model of antigen-driven lymphoproliferation similar to that reported for Helicobacter pylori-related gastric MALT lymphomas has been hypothesized for OAML...
May 2008: Annals of Oncology: Official Journal of the European Society for Medical Oncology
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