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luteal phase deficiency

Olivia J Hall, Nathachit Limjunyawong, Meghan S Vermillion, Dionne P Robinson, Nicholas Wohlgemuth, Andrew Pekosz, Wayne Mitzner, Sabra L Klein
Over 100 million women use progesterone therapies worldwide. Despite having immunomodulatory and repair properties, their effects on the outcome of viral diseases outside of the reproductive tract have not been evaluated. Administration of exogenous progesterone (at concentrations that mimic the luteal phase) to progesterone-depleted adult female mice conferred protection from both lethal and sublethal influenza A virus (IAV) infection. Progesterone treatment altered the inflammatory environment of the lungs, but had no effects on viral load...
September 2016: PLoS Pathogens
Elizabeth R Bertone-Johnson, Serena C Houghton, Brian W Whitcomb, Lynnette L Sievert, Sofija E Zagarins, Alayne G Ronnenberg
OBJECTIVE: The prevalence of hypertension in premenopausal women is increasing. There is substantial need for novel strategies to identify women who would benefit from increased screening and early interventions. Several mechanisms likely contributing to premenstrual syndrome (PMS) are also involved in hypertension, including renin-angiotensin-aldosterone system dysfunction and micronutrient deficiencies. However, it is unknown whether young women with PMS have elevated blood pressure...
July 15, 2016: Journal of Women's Health
Shuo Huang, Yanli Pang, Jie Yan, Shengli Lin, Yue Zhao, Li Lei, Liying Yan, Rong Li, Caihong Ma, Jie Qiao
Low progesterone levels are associated with luteal phase deficiency in women with polycystic ovary syndrome (PCOS). The mechanisms regulating progesterone biosynthesis in the granulosa cells from women with PCOS is largely unknown. Fractalkine is expressed in human ovaries, and is reported to regulate progesterone production in granulosa cells of healthy women. In the current study, we aimed to examine the role of fractalkine in women with PCOS. Reduced fractalkine levels were found in follicular fluid and granulosa cells, accompanied by decreased progesterone production and reduced steroidogenic acute regulatory protein (StAR) expression in the granulosa cells of patients with PCOS...
2016: Scientific Reports
Kirk P Conrad
BACKGROUND: Important roles for G-protein-coupled receptors (GPCRs) have been identified in the maternal physiological adaptations to pregnancy and in the pathogenesis of preeclampsia. On this basis, GPCRs are potential therapeutic targets for preeclampsia. OBJECTIVES AND RATIONALE: In this review, vasopressin and apelin are initially considered in this context before the focus on the hormone relaxin and its cognate receptor, the relaxin/insulin-like family peptide receptor 1 (RXFP1)...
September 2016: Human Reproduction Update
J H Check, J R Liss, G DiAntonio, D Summers
PURPOSE: To discover if infertile women with presumed luteal phase deficiency would improve pregnancy rates, mid-luteal sera estradiol (E2) and progesterone (P), and increase the percentage of women achieving a mid-luteal sonographic homogeneous hyperechogenic endometrial texture by the addition of a single injection of human chorionic gonadotropin (hCG). MATERIALS AND METHODS: Women with over one year of infertility with regular menses and with no other known infertility factor were presumed to have the need for extra P in the luteal phase based on previous studies...
2016: Clinical and Experimental Obstetrics & Gynecology
Ravichandran Nadarajah, Hemashree Rajesh, Ker Yi Wong, Fazlin Faisal, Su Ling Yu
INTRODUCTION: Assisted reproductive techniques (ARTs) result in a deficient luteal phase, requiring the administration of exogenous progesterone intramuscularly, intravaginally or orally. Dydrogesterone, an oral retroprogesterone, has good bioavailability; it has been used in assisted reproductive cycles with outcomes comparable to those of vaginal or intramuscular progesterone. However, there are limited reviews on the use of dydrogesterone for luteal phase support in ARTs in terms of pregnancy outcomes and associated fetal anomalies...
April 19, 2016: Singapore Medical Journal
Fadi Ghazi Mirza, Ameet Patki, Claire Pexman-Fieth
Successful oocyte implantation and a favorable pregnancy outcome rely on optimal progesterone levels. Therefore, progesterone deficiencies associated with infertility and miscarriage have commonly been treated with progestogens that mimic the activity of progesterone. Among those is dydrogesterone, an oral retrosteroid with a structure closely related to that of progesterone yet with a greater bioavailability and higher selectivity for the progesterone receptor. This review describes the efficacy of dydrogesterone for the treatment of threatened and recurrent miscarriage, and infertility due to luteal phase insufficiency...
2016: Gynecological Endocrinology
Stefano Palomba, Susanna Santagni, Giovanni Battista La Sala
Luteal phase deficiency (LPD) is described as a condition of insufficient progesterone exposure to maintain a regular secretory endometrium and allow for normal embryo implantation and growth. Recently, scientific focus is turning to understand the physiology of implantation, in particular the several molecular markers of endometrial competence, through the recent transcriptomic approaches and microarray technology. In spite of the wide availability of clinical and instrumental methods for assessing endometrial competence, reproducible and reliable diagnostic tests for LPD are currently lacking, so no type-IA evidence has been proposed by the main scientific societies for assessing endometrial competence in infertile couples...
2015: Journal of Ovarian Research
Donya Khosravi, Robabeh Taheripanah, Anahita Taheripanah, Vahid Tarighat Monfared, Seyed-Mostafa Hosseini-Zijoud
BACKGROUND: The aim of this study, we have compared the advantages of oral dydrogestrone with vaginal progesterone (cyclogest) for luteal support in intrauterine insemination (IUI) cycles. Progesterone supplementation is the first line treatment when luteal phase deficiency (LPD) can reasonably be assumed. OBJECTIVE: This study was conduct to compare the effect of oral dydrogestrone with vaginal Cyclogest on luteal phase support in the IUI cycles. MATERIALS AND METHODS: This prospective, randomized, double blind study was performed in a local infertility center from May 2013 to May 2014...
July 2015: Iranian Journal of Reproductive Medicine
Karen C Schliep, Shvetha M Zarek, Enrique F Schisterman, Jean Wactawski-Wende, Maurizio Trevisan, Lindsey A Sjaarda, Neil J Perkins, Sunni L Mumford
BACKGROUND: Although habitual low-to-moderate alcohol intake has been linked with reduced all-cause mortality and morbidity, the effect of recent alcohol intake on female reproductive function has not been clearly established. OBJECTIVE: We assessed the relation between acute alcohol consumption, reproductive hormones, and markers of menstrual cycle dysfunction including sporadic anovulation, irregular cycle length, luteal phase deficiency, long menses, and heavy blood loss...
October 2015: American Journal of Clinical Nutrition
Mahshid Taheri, Azam Baheiraei, Abbas Rahimi Foroushani, Bahram Nikmanesh, Maryam Modarres
BACKGROUND & OBJECTIVES: Bacterial vaginosis (BV) is the most prevalent vaginal infection in women of reproductive age group which has been found to be associated with vitamin D deficiency. The purpose of this study was to investigate the effectiveness of the administration of 2000 IU/day edible vitamin D for 15 wk to eliminate asymptomatic BV among reproductive age women with vitamin D deficiency. METHODS: A total of 208 women with asymptomatic BV, who were found to be eligible after interviews and laboratory tests, were randomly assigned to a control group (n=106) or an intervention group (n=105)...
June 2015: Indian Journal of Medical Research
Mary A Andrews, Karen C Schliep, Jean Wactawski-Wende, Joseph B Stanford, Shvetha M Zarek, Rose G Radin, Lindsey A Sjaarda, Neil J Perkins, Robyn A Kalwerisky, Ahmad O Hammoud, Sunni L Mumford
STUDY QUESTION: Are prospectively assessed dietary factors, including overall diet quality, macronutrients and micronutrients, associated with luteal phase deficiency (LPD) in healthy reproductive aged women with regular menstrual cycles? SUMMARY ANSWER: Mediterranean Diet Score (MDS), fiber and isoflavone intake were positively associated with LPD while selenium was negatively associated with LPD after adjusting for age, percentage body fat and total energy intake...
August 2015: Human Reproduction
Alexandra Tijerina-Sáenz, Nancy E Martínez-Garza, Erik Ramírez-López, Elizabeth Solís-Pérez, Adbel Z Martínez-Báez
INTRODUCTION: Obesity is reported to be a predictor of iron deficiency. In Mexico, 45.5% of women older than 20 years have obesity, and the prevalence of anemia is 10.2% in women 20 to 29 years. OBJECTIVE: To investigate the relation between body mass index (BMI), percentage of body fat (% BF), dietary intakes and iron status of healthy normal-weight and obese young women. METHODS: A total of 86 women [normal-weight (n = 46) and obese (n = 40)] completed the study...
2015: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
(no author information available yet)
Luteal phase deficiency (LPD) has been described in healthy normally menstruating women and in association with other medical conditions. Although progesterone is important for the process of implantation and early embryonic development, LPD, as an independent entity causing infertility, has not been proven. This document replaces the document by the same name, last published in 2012 (Fertil Steril 2012;98:1112-7).
April 2015: Fertility and Sterility
Tolga B Mesen, Steven L Young
Progesterone production from the corpus luteum is critical for natural reproduction. Progesterone supplementation seems to be an important aspect of any assisted reproductive technology treatment. Luteal phase deficiency in natural cycles is a plausible cause of infertility and pregnancy loss, though there is no adequate diagnostic test. This article describes the normal luteal phase of the menstrual cycle, investigates the controversy surrounding luteal phase deficiency, and presents the current literature for progesterone supplementation during assisted reproductive technologies...
March 2015: Obstetrics and Gynecology Clinics of North America
P Warner, C J Weir, C H Hansen, A Douglas, M Madhra, S G Hillier, P T K Saunders, J P Iredale, S Semple, B R Walker, H O D Critchley
INTRODUCTION: Heavy menstrual bleeding (HMB) diminishes individual quality-of-life and poses substantial societal burden. In HMB endometrium, inactivation of cortisol (by enzyme 11β hydroxysteroid dehydrogenase type 2 (11βHSD2)), may cause local endometrial glucocorticoid deficiency and hence increased angiogenesis and impaired vasoconstriction. We propose that 'rescue' of luteal phase endometrial glucocorticoid deficiency could reduce menstrual bleeding. METHODS AND ANALYSIS: DexFEM is a double-blind response-adaptive parallel-group placebo-controlled trial in women with HMB (108 to be randomised), with active treatment the potent oral synthetic glucocorticoid dexamethasone, which is relatively resistant to 11βHSD2 inactivation...
2015: BMJ Open
W L Gao, L S Wu, J H Zi, B Wu, Y Z Li, Y C Song, D Z Cai
Although 17β-estradiol (E2) deficiency has been linked to the development of osteoarthritis (OA) in middle-aged women, there are few studies relating other estrogens and estrogen metabolites (EMs) to this condition. We developed a high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry (HPLC-ESI-MS/MS) method to measure the levels of six EMs (i.e., estrone, E2, estriol, 2-hydroxyestrone, 2-hydroxyestradiol, and 16a-hydroxyestrone) in healthy pre- and postmenopausal women and women with OA...
February 2015: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
Nancy I Williams, Heather J Leidy, Brenna R Hill, Jay L Lieberman, Richard S Legro, Mary Jane De Souza
We assessed the impact of energy deficiency on menstrual function using controlled feeding and supervised exercise over four menstrual cycles (1 baseline and 3 intervention cycles) in untrained, eumenorrheic women aged 18-30 yr. Subjects were randomized to either an exercising control (EXCON) or one of three exercising energy deficit (ED) groups, i.e., mild (ED1; -8 ± 2%), moderate (ED2; -22 ± 3%), or severe (ED3; -42 ± 3%). Menstrual cycle length and changes in urinary concentrations of estrone-1-glucuronide, pregnanediol glucuronide, and midcycle luteinizing hormone were assessed...
January 1, 2015: American Journal of Physiology. Endocrinology and Metabolism
Nadège Michaud, Mahera Al-Akoum, Ali Akoum
BACKGROUND: A deficiency in the counter-regulatory mechanisms of interleukin 1 (IL1) may play a significant role in endometriosis pathogenesis and associated chronic inflammation. The aim of this study was to investigate peripheral blood levels of soluble IL1 receptor accessory protein (sIL1RAP), a potent natural inhibitor of IL1, in women with and without endometriosis. METHODS: Peripheral blood samples were collected from women with endometriosis (n = 47) consulting for infertility, pelvic pain or tubal ligation, in whom the disease was diagnosed at laparoscopy...
2014: Reproductive Biology and Endocrinology: RB&E
Hongjie Pan, Hengxiang Cui, Shijie Liu, Yu Qian, Haili Wu, Liang Li, Yuting Guan, Xin Guan, Long Zhang, Heng-Yu Fan, Yanlin Ma, Runsheng Li, Mingyao Liu, Dali Li
Luteal-phase insufficiency is one of the major causes of female infertility, but the molecular mechanisms are still largely unknown. Here we found that disruption of Lgr4/Gpr48, the newly identified receptor for R-spondins, greatly reduced female fertility in mice. The expression of Lgr4 was induced specifically in granulosa-lutein cells during luteinization. In Lgr4-deficient female mice, the estrous cycle was prolonged and serum progesterone levels were dramatically downregulated. In Lgr4(-/-) corpora lutea, the expression of key enzymes for steroidogenesis as well as common luteal marker genes was significantly decreased...
September 2014: Endocrinology
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