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https://www.readbyqxmd.com/read/28933699/pyoderma-gangrenosum-an-uncommon-case-report-and-review-of-the-literature
#1
António Carlos Lemos, Debora Aveiro, Natália Santos, Vítor Marques, Luís Filipe Pinheiro
BACKGROUND: Pyoderma gangrenosum (PG) is a rare ulcerative condition that is diagnostically and therapeutically challenging, as debridement leads to ulcer deterioration (pathergy phenomenon); immunosuppression is considered the gold standard therapy. CASE REPORT: The authors present the case of a 42-year-old woman with PG and uncontrolled iatrogenic diabetes, secondary to a total pancreatectomy performed in another hospital in 1998 due to nesidioblastosis. In 2008, she was referred to the diabetic foot consultation at Centro Hospitalar Tondela-Viseu (Viseu, Portugal) due to an infected wound on the left leg thought to be related to a trauma from footwear, but the injury worsened despite treatment...
September 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28932886/immediate-responses-of-the-cockroach-blaptica-dubia-after-the-exposure-to-sulfur-mustard
#2
Tanja Popp, Robin Lüling, Ingrid Boekhoff, Thomas Seeger, Francisco Branoner, Thomas Gudermann, Horst Thiermann, Franz Worek, Dirk Steinritz
The chemical agent sulfur mustard (SM) causes erythema, skin blisters, ulcerations, and delayed wound healing. It is accepted that the underlying molecular toxicology is based on DNA alkylation. With an expected delay, DNA damage causes impairment of protein biosynthesis and disturbance of cell division. However, using the cockroach model Blaptica dubia, the presented results show that alkylating compounds provoke immediate behavior responses along with fast changes in the electrical field potential (EFP) of neurons, suggesting that lesions of DNA are probably not the only effect of alkylating compounds...
September 20, 2017: Archives of Toxicology
https://www.readbyqxmd.com/read/28932317/ventral-abdominal-hernia
#3
Georgi Tchernev, Anastasiya Chokoeva, Jacopo Lotti, Katlein França, Torello Lotti
A 63-year-old Caucasian female patient presented with redness of the both foot and lower legs, as well as edema of the left lower leg, accompanied by subjective complaints of burning. Fever was not reported. Well-circumscribed oval shaped tumor formation was revealed also on the abdominal wall, with hyperpigmented and depigmented areas on its ulcerated surface, measuring approximately 10/10cm in diameter, with soft-elastic texture on palpation. The lesion occurred in 2011, according to the patient's history...
August 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28931524/degree-of-anemia-indirect-markers-of-hemolysis-and-vascular-complications-of-sickle-cell-disease-in-africa
#4
Marie Dubert, Jacques Elion, Aissata Tolo, Dapa Aly Diallo, Saliou Diop, Ibrahima Diagne, Ibrahima Sanogo, Suzanne Belinga, Odette Guifo, Guillaume Wamba, Françoise Ngo Sack, Kouakou Boidy, Ismael Kamara, Youssouf Traore, Cheick Oumar Diakite, Valérie Gbonon, Blaise Felix Faye, Moussa Seck, Indou Deme Ly, David Chelo, Roland N'Guetta, Ibrahima Bara Diop, Bamba Gaye, Xavier Jouven, Brigitte Ranque
The hyperhemolysis paradigm that describes overlapping "hyperhemolytic-endothelial dysfunction" and "high hemoglobin-hyperviscous" subphenotypes of sickle cell disease (SCD) patients is based on North American studies. We performed a transversal study nested in the CADRE cohort to analyze the association between steady-state hemolysis and vascular complications of SCD among sub-Saharan African patients. In Mali, Cameroon, and Ivory Coast, 2,407 SCD patients (1,751 SS-Sβ(0), 495 SC and 161 Sβ(+)), aged three years old and over, were included at steady-state...
September 20, 2017: Blood
https://www.readbyqxmd.com/read/28931509/development-and-validation-of-qmortality-risk-prediction-algorithm-to-estimate-short-term-risk-of-death-and-assess-frailty-cohort-study
#5
Julia Hippisley-Cox, Carol Coupland
Objectives To derive and validate a risk prediction equation to estimate the short term risk of death, and to develop a classification method for frailty based on risk of death and risk of unplanned hospital admission.Design Prospective open cohort study.Participants Routinely collected data from 1436 general practices contributing data to QResearch in England between 2012 and 2016. 1079 practices were used to develop the scores and a separate set of 357 practices to validate the scores. 1.47 million patients aged 65-100 years were in the derivation cohort and 0...
September 20, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28923584/seeing-the-difference-painless-progressive-vision-loss-in-a-vasculopath
#6
Jenny L Lauschke, Katherine Masselos, Jennifer Sandbach, Clare L Fraser
A 78-year-old Caucasian man with significant vascular disease reported sudden onset of worsened vision during a routine wound-care appointment for non-healing necrotic leg ulcers. He described painless blurring of vision with grey scotomas in his RE, his only well-seeing eye, following trauma to the LE as a child. He presented with retinal ischemia, a cotton-wool spot and optic nerve swelling. Temporal artery biopsy showed myxoid degeneration and extensive calcium deposition which also was shown on imaging throughout his carotid and vertebral arterial system, the clinical picture of calciphylaxis...
September 15, 2017: Survey of Ophthalmology
https://www.readbyqxmd.com/read/28923443/-leg-ulcer-ankle-brachial-pressure-index-and-the-role-of-the-nurse
#7
REVIEW
Maria Consolación Cano Sanchez
The measurement of the ankle-brachial pressure index is essential for the treatment of leg ulcers. In the framework of the imminent implementation of advanced practices in France, nurses specifically trained in wound care and healing could be authorised to take and interpret this measurement. Venous compression techniques could therefore be adapted more precisely to the needs of the patients.
September 2017: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/28922511/reliability-and-measurement-error-of-digital-planimetry-for-the-measurement-of-chronic-venous-leg-ulcers
#8
Michael Stacey, Steven Phillips, Forough Farrokhyar, Jillian M Swaine
Area measurements of a chronic wound are the gold standard outcome measure to determine if a wound is on a healing or non-healing trajectory. The use of digital planimetry can provide increased accuracy in measuring wound area however it is important to know the reliability and measurement error of these devices when used by multiple assessors. The aim of this study is to determine the within rater, between rater, and standard error of measurement of a digital planimetry device. Wound area in 42 patients was measured weekly for 12 weeks by two different raters, with each rater measuring the wound 10 times per visit...
September 18, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/28919009/distinct-patterns-of-response-to-transfusion-therapy-for-different-chronic-complications-of-sickle-cell-disease-a-useful-insight
#9
Dimitris A Tsitsikas, Funmilayo Orebayo, Alexandra Agapidou, Roger J Amos
Two main sub-phenotypes have been described in sickle cell disease: one with higher baseline haemoglobin and a higher rate of painful crises and one with lower baseline haemoglobin, increased markers of haemolysis and a higher incidence of pulmonary hypertension, priapism and leg ulcers. We compared the patterns of response to regular automated red cell exchange transfusion over a five-year period of 21 patients with recurrent painful crises from the first group and 3 patients with pulmonary hypertension and 5 with recurrent severe stuttering priapism form the second and found them to be distinctly different...
August 18, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28917483/recalcitrant-chronic-leg-ulcer-an-indication-for-patch-testing-for-hydrocolloid-dressing
#10
Che-Yuan Hsu, Woan-Ruoh Lee, Yi-Hsien Shih
No abstract text is available yet for this article.
October 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28914682/refractory-ulcerated-necrobiosis-lipoidica-closure-of-a-difficult-wound-with-topical-tacrolimus
#11
Luke Ginocchio, Lisa Draghi, Farbod Darvishian, Frank L Ross
OBJECTIVE: To report a case of refractory ulcerated necrobiosis lipoidica (NL) with significant response to treatment with topical tacrolimus. SUBJECT: A 55-year-old woman without diabetes and with a previous history of NL presented to the Helen L. and Martin S. Kimmel Hyperbaric and Advanced Wound Healing Center of NYU Langone Medical Center, New York, with bilateral lower-leg ulcerations resistant to wound healing techniques at other institutions. MATERIALS AND METHODS: Repeat biopsy performed at the author's institution confirmed the diagnosis of NL...
October 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28914681/randomized-controlled-trial-comparing-collagen-oxidized-regenerated-cellulose-silver-to-standard-of-care-in-the-management-of-venous-leg-ulcers
#12
Breda M Cullen, Thomas E Serena, Molly C Gibson, Robert J Snyder, Jason R Hanft, Raphael A Yaakov
OBJECTIVE: To assess healing outcomes in venous leg ulcers (VLUs) treated with a combination of collagen, oxidized regenerated cellulose, and silver in conjunction with standard of care (SOC; intervention group) compared with SOC alone (control group). Standard of care included ADAPTIC nonadhering dressing (Acelity, San Antonio, Texas) and compression. DESIGN AND SETTING: Randomized controlled trial that followed patients in 3 US facilities for 12 weeks or until complete healing...
October 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28914679/reliability-of-a-skin-diagnostic-device-in-assessing-hydration-and-erythema
#13
Koh Huimin, Alexandra M Rowledge, Caroline J Borzdynski, Charne Miller, Nicoletta Frescos, Gayle McKenzie, Elizabeth Perry, William McGuiness
OBJECTIVE: To examine the reliability of a skin diagnostic device, the SD202 (Courage+Khazaka GmBH, Cologne, Germany), in assessing hydration and erythema of periwound skin and pressure injury-prone areas. DESIGN: Intrarater reliabilities from 3 cross-sectional and prospective studies are reported. SETTING AND PARTICIPANTS: Patients attending an outpatient, nurse-led wound dressing clinic (n = 16), a podiatrist-led high-risk foot clinic (n = 17), and residents (n = 38) at a single residential aged-care facility...
October 2017: Advances in Skin & Wound Care
https://www.readbyqxmd.com/read/28905242/poly-n-acetyl-glucosamine-snag-enhances-early-rotator-cuff-tendon-healing-in-a-rat-model
#14
C A Nuss, J Huegel, J F Boorman-Padgett, D S Choi, S N Weiss, J Vournakis, L J Soslowsky
Rotator cuff injuries frequently require surgical repairs which have a high failure rate. Biological augmentation has been utilized in an attempt to improve tendon repair. Poly-N-acetyl glucosamine (sNAG) polymer containing nanofibers has been shown to increase the rate for healing of venous leg ulcers. The purpose of this study was to investigate the healing and analgesic properties of sNAG in a rat rotator cuff injury and repair model. 144 adult male Sprague-Dawley rats underwent a transection and repair of their left supraspinatus tendons...
September 13, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28900445/anaphylactoid-purpura-associated-with-streptococcal-cellulitis-a-case-report-and-literature-review
#15
Yuko Saito, Susumu Ookawara, Hisataka Uchima, Takeshi Ishida, Masafumi Kakei, Hitoshi Sugawara
A 54-year-old Japanese man noticed painful swelling and redness of his left leg. He was admitted for treatment of cellulitis, which was accompanied with increased anti-streptolysin O and anti-streptokinase titers in his clinical course. After Piperacillin/Tazobactam administration, the skin lesion resolved. However, the patient then developed arthritis, palpable purpura, and intermittent abdominal pain, later found to be secondary to a severe duodenal ulcer. He was diagnosed with cellulitis-associated anaphylactoid purpura and was given prednisolone, which dramatically improved his symptoms...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28880752/evaluation-of-osteopontin-expression-in-chronic-wounds-a-potential-prognostic-and-therapeutic-biomarker
#16
S Chimento, V Billero, L Cavallin, M Romanelli, M Nadji, P Romanelli
OBJECTIVE: Osteopontin (OPN) is abundantly expressed during tissue repair, acting as a powerful chemokine that recruits inflammatory cells such as neutrophils, macrophages, and Langerhans cells. The role of OPN in chronic wounds has not been explored. In this study, we assess the expression levels of OPN in chronic wounds to assess its potential contribution to the exacerbated inflammation seen in chronic ulcers, which is thought to contribute to poor healing. METHODS: This retrospective study included archived biopsies of chronic wounds from several aetiologies...
September 1, 2017: Journal of Wound Care
https://www.readbyqxmd.com/read/28877306/a-violaceous-photodistributed-cutaneous-eruption-and-leg-ulcer-in-a-woman-with-essential-thrombocytosis
#17
Jody Platto, Christina E Alexander, Drew J B Kurtzman
No abstract text is available yet for this article.
September 6, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28875518/quality-of-life-evaluation-in-chronic-wounds-comparative-analysis-of-three-disease-specific-questionnaires
#18
Matthias Augustin, Katrin Baade, Kristina Heyer, Patricia E Price, Katharina Herberger, Thomas Wild, Michael Engelhardt, Eike S Debus
The study directly compared the feasibility and performance of three instruments measuring health-related quality of life (HRQoL) in chronic ulcers: the Freiburg Life Quality Assessment for wounds (FLQA-w), the Cardiff Wound Impact Schedule (CWIS) and the Würzburg Wound Score (WWS). The questionnaires were evaluated in a randomly assigned order in a longitudinal observational study of leg ulcer patients. Psychometric properties (internal consistency, responsiveness and construct validity) were analysed. Patient acceptance was recorded...
September 6, 2017: International Wound Journal
https://www.readbyqxmd.com/read/28873064/a-systematic-review-and-meta-analysis-of-exercise-intervention-for-the-treatment-of-calf-muscle-pump-impairment-in-individuals-with-chronic-venous-insufficiency
#19
Lyndsay Orr, Kathleen A Klement, Laura McCrossin, Deirdre O'Sullivan Drombolis, Pamela E Houghton, Sandi Spaulding, Shauna Burke
Exercise intervention for individuals with chronic venous insufficiency (CVI) and venous leg ulcers (VLUs) is recommended to improve function of the calf muscle pump (CMP). A systematic review with meta-analysis was conducted to measure the effects of exercise (including function of the CMP, ankle strength, range of motion [ROM], and healing rates) for VLUs. Four (4) databases (Cumulative Index to Nursing and Applied Health Literature, 1981; MEDLINE, 1964; Scopus, 1966; and EMBASE, 1947) were searched for relevant articles from the date of index inception to January 2016...
August 2017: Ostomy/wound Management
https://www.readbyqxmd.com/read/28867534/-vitamin-k-antagonist-induced-necrotic-leg-ulcer-without-protein-c-and-s-deficiencies
#20
F Kurihara, E Tella, M-L Sigal, E Mahé
INTRODUCTION: Patients treated by vitamin K antagonists (VKA) represent 1% of the population in France. We report a case of atypical necrotic leg ulcers induced by VKA. CASE REPORT: A 84-year-old woman was referred to our dermatology department because of necrotic leg ulcers that developed for the past 5weeks, and appeared spontaneously after the introduction of a VKA, fluindione. The etiological assessment was non contributive, in particular the search for thrombophilic factors...
August 31, 2017: La Revue de Médecine Interne
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