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Pouria HosseinNia, Mehdi Hajian, Mojtaba Tahmoorespur, Sayyed Morteza Hosseini, Somayyeh Ostadhosseini, Mohammad Reza Nasiri, Mohammad Hossein Nasr-Esfahani
BACKGROUND: Little is understood about the regulation of gene expression during early goat embryo development. This study investigated the expression profile of 19 genes, known to be critical for early embryo development in mouse and human, at five different stages of goat in vitro embryo development (oocyte, 8-16 cell, morula, day-7 blastocyst, and day 14 blastocyst). MATERIALS AND METHODS: In this experimental study, stage-specific profiling using real time-quantitative polymerase chain reaction (RT-qPCR) revealed robust and dynamic patterns of stage-specific gene activity that fall into four major clusters depending on their respective mRNA profiles...
October 2016: International Journal of Fertility & Sterility
Vahid Khoshkam, Fernando Suárez-López Del Amo, Alberto Monje, Guo-Hao Lin, Hsun-Liang Chan, Hom-Lay Wang
PURPOSE: The purpose of this systematic review was to evaluate long-term outcomes of regenerative procedures for treating peri-implantitis. MATERIALS AND METHODS: Electronic searches of five databases and hand searches of journals were performed to identify human trials that had treated more than 10 periimplantitis lesions using a regenerative approach with a follow-up period of at least 36 months. To meet the inclusion criteria, studies had to report at least one of the following parameters: radiographic bone fill (RBF), probing depth (PD) reduction, clinical attachment level gain, bleeding on probing reduction, and mucosal level gain...
September 6, 2016: International Journal of Oral & Maxillofacial Implants
Ausra Ramanauskaite, Gintaras Juodzbalys, Tolga F Tözüm
OBJECTIVES: To review the literature on retrograde periimplantitis symptoms, risk factors, and treatment methods and to propose a decision-making tree of retrograde periimplantitis management. MATERIALS AND METHODS: An electronic literature search was conducted on the MEDLINE and EMBASE databases for articles published between 1990 and 2015. Clinical human studies in the English language were included. RESULTS: The search resulted in 44 case reports published by 27 authors...
October 2016: Implant Dentistry
Paul S Rosen, Stuart J Froum
The biologic complication of peri-implantitis threatens the survival of dental implants that have successfully integrated and are in function. A list of seven risk factors associated with this disease was generated in 2006 at the Sixth European Workshop on Periodontology. These factors were based on the prevailing literature. Since then, modifications to this list have been considered whereby some of the original items suggested to be associated with periimplantitis would be deleted, while, in light of evidence-based information, newer, emerging risks may be included...
July 2016: Compendium of Continuing Education in Dentistry
Juliano Milanezi de Almeida, Henrique Rinaldi Matheus, David Jonathan Rodrigues Gusman, Paula Lazilha Faleiros, Nathália Januário de Araújo, Vivian Cristina Noronha Novaes
OBJECTIVE: This study aimed to perform a systematic review of the effectiveness of nonsurgical treatment associated with different adjuvant therapies on periimplantitis. MATERIALS AND METHODS: Different individuals, following a research process, performed a network research of controlled and randomized controlled clinical trials on PubMed, Embase/MEDLINE, with 20 years' time constraint and the last search in January 2016. RESULTS: From 108 articles found by the first search, they analyzed 10 full texts, and in none did they find a standard control group...
August 19, 2016: Implant Dentistry
Rucha Shah, Raison Thomas, Tarun Kumar, Dhoom Singh Mehta
BACKGROUND: Retrograde periimplantitis (RPI) is the inflammatory disease that affects the apical part of an osseointegrated implant while the coronal portion of the implant sustains a normal bone-to-implant interface. The aim of the current study was to assess the intraexaminer and interexaminer reliability of a proposed new classification system for RPI. MATERIALS AND METHODS: After thorough electronic literature search, 56 intraoral periapical radiographs (IOPA) of implants with RPI were collected and were classified by 2 independent reviewers as per the new classification system into one of the 3-mild, moderate, and advanced-classes based on the amount of bone loss from the apex of the implant to the most coronal part as a percentage of the total implant length...
August 18, 2016: Implant Dentistry
Bernhard Pommer, Robert Haas, Georg Mailath-Pokorny, Rudolf Fürhauser, Georg Watzek, Dieter Busenlechner, Michael Müller-Kern, Claudia Kloodt
PURPOSE: Periimplantitis is the most frequent cause of late implant failure; however, little is known about the long-term success of periimplantitis treatment and the effectiveness of various therapeutic interventions. MATERIALS AND METHODS: A total of 142 patients were referred to the Academy for Oral Implantology in Vienna for the treatment of recurrent periimplantitis around single-tooth implants. Of them, 72 patients (51%) were treated by laser decontamination, 47 patients (33%) by implantoplasty surgery, and 23 patients (16%) by a combination of both approaches...
October 2016: Implant Dentistry
Melissa S Lang, D Roselyn Cerutis, Takanari Miyamoto, Martha E Nunn
PURPOSE: The aim of this study was to evaluate the surface characteristics and gingival fibroblast adhesion of disks composed of implant and abutment materials following brief and repeated instrumentation with instruments commonly used in procedures for implant maintenance, stage-two implant surgery, and periimplantitis treatment. MATERIALS AND METHODS: One hundred twenty disks (40 titanium, 40 titaniumzirconium, 40 zirconia) were grouped into treatment categories of instrumentation by plastic curette, titanium curette, diode microlaser, rotary titanium brush, and no treatment...
July 2016: International Journal of Oral & Maxillofacial Implants
Michael R Norton
INTRODUCTION: Sinus grafts are a safe and predictable treatment for increasing bone volume in the posterior maxilla. Common complications include membrane perforations and postoperative infection. Little is published with regard to late-onset infection except as it relates to periimplantitis. This report presents a case of late sequestration of bovine bone mineral graft fully consolidated within host lamellar bone, 8 years postsinus lift. Histology revealed mature lamellar bone encapsulating well-integrated particles of bovine bone material with evidence of devitalization and marrow spaces filled with a dense neutrophil infiltrate and a filamentous mixed microbial flora...
August 2016: Implant Dentistry
Daehyun Lee, Byungjin Sohn, Kyoung Hwa Kim, Sungtae Kim, Ki-Tae Koo, Tae-Il Kim, Yang-Jo Seol, Yong-Moo Lee, In-Chul Rhyu, Young Ku
BACKGROUND: There have been previous studies on the relationship between periodontitis and peri-implantitis, but limited information is available on how periodontitis affects osseointegration and wound healing of newly placed dental implants adjacent to natural teeth. The objective of the present experiment is to evaluate healing around dental implants adjacent to teeth with untreated experimental periodontitis. METHODS: The study included six male beagle dogs. Scaling and plaque control procedures were performed on three dogs (control group)...
October 2016: Journal of Periodontology
Tomas Albrektsson, Luigi Canullo, David Cochran, Hugo De Bruyn
BACKGROUND: The discrepancy between some scientific views and the daily clinical experience with dental implants has made the topic of "periimplantitis" highly controversial, especially the discussion whether "periimplantitis" should even be considered a "disease" or whether marginal bone loss instead would represent a complication of having a foreign body placed in the oral cavity. PURPOSE: The aim of the present paper was to present the outcomes from a consensus meeting on "peri-implantitis" in Rome, Italy (January 8-10, 2016)...
August 2016: Clinical Implant Dentistry and related Research
Hye-Min Ku, Mi-Kyoung Jun, Jee-Hwan Kim, Ho-Keun Kwon, Baek-Il Kim
INTRODUCTION: It is important to identify the reasons for implant failure when planning future dental treatment. No studies have distinguished the factors that affect implant failure by evaluating the appearance of failed fixtures. PURPOSE: This study investigated these factors by evaluating the surface of implant fixtures using quantitative light-induced fluorescence-digital (QLF-D), which involves detecting the red fluorescence emitted by porphyrin metabolized by oral bacteria in a mature biofilm...
June 2016: Implant Dentistry
Ali Al-Ahmad, Lamprini Karygianni, Max Schulze Wartenhorst, Maria Bächle, Elmar Hellwig, Marie Follo, Kirstin Vach, Jung-Suk Han
Bacterially-driven mucosal inflammation and the development of periimplantitis can lead to oral implant failure. In this study, initial bacterial adhesion after 2 h and biofilm formation after 1 day and 3 days were analyzed in situ on novel 3 mol% yttria-stabilized tetragonal zirconia polycrystal samples (Zr; 3Y-TZP), as well as on alumina and niobium co-doped yttria-stabilized tetragonal zirconia samples (Al-Zr; Al2O3/Y(Nb)-TZP). Pure titanium implant material (Ti) and bovine enamel slabs (BES) served as controls...
April 19, 2016: Journal of Medical Microbiology
Roberto Gonçalves Junior, Aristides da Rosa Pinheiro, José Jorge Schoichet, Carlos Henrique Ramirez Nunes, Rackel Gonçalves, Leticia Ladeira Bonato, Valquiria Quinelato, Leonardo Santos Antunes, Erika Calvano Küchler, Julie Lobo, Ricardo de Mello Villas-Bôas, Alexandre Rezende Vieira, José Mauro Granjeiro, Priscila Ladeira Casado
Subjects susceptible to chronic periodontitis (CP) show a high risk for the development of periimplantitis (PI). Both diseases are multifactorial, presenting similarities in their pathophysiology and polygenic profile. MMP-13 (matrix metalloproteinases 13/ collagenase 3) is a collagenolytic enzyme, which expression is induced by TGF beta 3 (transforming growth factor type 3) in human gingival fibroblasts and inhibited by TIMP-2 (tissue inhibitor of metalloproteinase type 2). The aim of this study was to investigate the occurrence of periimplantitis (PI) in subjects with history of chronic periodontitis (CP) and polymorphisms frequency in MMP13, TIMP2 and TGFB3 genes...
March 2016: Brazilian Dental Journal
Balendra Pratap Singh, Hemant Jivanani
Around 1300 different types of dental implants are available worldwide and the implant manufacturers are resorting to aggressive marketing strategies; claiming their implants to provide a superior outcome. The clinician is left with a constant dilemma on which implant to choose for better clinical outcome and welfare of the patient. Moreover, in India, economical consideration is a concern too. The dentist has to select an implant that provides a good result and is economical. Cochrane systematic reviews provide the gold standard evidence for intervention, diagnosis, etc...
July 2015: Journal of Indian Prosthodontic Society
Shuangbo Kong, Xue Han, Tongtong Cui, Chan Zhou, Yufei Jiang, Hangxiao Zhang, Bingyan Wang, Haibin Wang, Shuang Zhang
Uterine decidualization characterized by stromal cell proliferation and differentiation is critical to the establishment of pregnancy in many species. Progesterone is a key factor in regulating endometrial cell decidualization, however, the molecular basis involved in mediating the effects of progesterone during decidualization remains largely unknown. We report here that the DNA replication licensing factor MCM2, one of the conserved set of six-related proteins (MCM complex: MCM2-7) essential for eukaryotic DNA replication, is dynamically expressed in both proliferative and differentiated stromal cells during mouse periimplantation uterus...
August 2016: Endocrine
Lélis Gustavo Nícoli, Suzane Cristina Pigossi, Cláudio Marcantonio, Daniela Leal Zandim-Barcelos, Elcio Marcantonio
PURPOSE: The aim of this case report is to describe the surgical treatment of 2 implants affected by periimplantitis after 15 years of loading. MATERIALS AND METHODS: The treatment included mechanical and chemical decontamination with topical application of tetracycline associated with a regenerative approach. Both defects were filled with particulate autogenous bone from tuber and covered with resorbable collagen membrane. RESULTS: The follow-up of 30 and 13 months of the implants 24 and 14, respectively, showed an absence of clinical signs of periimplant inflammation and near-complete bone regeneration...
April 2016: Implant Dentistry
Nisha Mahato, Xiaohong Wu, Lu Wang
Peri-implantitis or Periimplantitis is characterized as an inflammatory reaction that affects the hard and soft tissue, which results in loss of supporting bone and pocket formation surrounding the functioning osseointegrated implant. This review aimed to evaluate the effectiveness of surgical and non-surgical treatment of peri-implantitis. The data sources used was PubMed. Searches of this database were restricted to English language publications from January 2010 to June 2015. All Randomized Controlled Trials describing the treatments of peri-implantitis of human studies with a follow up of at least 6 months were included...
2016: SpringerPlus
Roberta Calcaterra, Michele Di Girolamo, Concetta Mirisola, Luigi Baggi
BACKGROUND: Gingival epithelial cells have a pivotal role in the recognition of microorganisms and damage-associated molecular pattern molecules and in the regulation of the immune response. The investigation of the behavior of Toll-like receptors (TLRs) and nucleotide oligomerization domain (NOD) like receptors (NLRs) around a healthy implant may help to address the first step of periimplantitis pathogenesis. PURPOSE: To investigate by quantitative real-time polymerase chain reaction, the mRNA expressions of TLR2, TLR3, TLR4, TLR5, TLR6, TLR9, NOD1, NOD2, and NLRP3 from gingival epithelial cells of the sulcus around healthy implants and around healthy teeth...
June 2016: Implant Dentistry
Henning Lünenbürger, Nikola Roknic, Martin Klein, Kai Wermker
BACKGROUND: Malignant tumors are the most frequent reason for acquired defects of the nose. Bone-anchored craniofacial prostheses represent a secure, uncomplicated, and cosmetically acceptable rehabilitative alternative to surgical reconstruction. The aim of this study was to determine a potential benefit of the Titanium Epiplating System (Fa. Medicon, Tuttlingen, Germany) as a grouped implant system in the anatomically difficult nasal region with limited bone supply. METHODS: Patients with complete nasal defects who received a transfacial Titanium Epiplating System between January of 2009 and December of 2013 for nasal prostheses were included...
February 2016: Plastic and Reconstructive Surgery
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