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https://www.readbyqxmd.com/read/27913750/congenital-heart-block-and-immune-mediated-sensorineural-hearing-loss-possible-cross-reactivity-of-immune-response
#1
C Bason, I Pagnini, A Brucato, S Maestroni, A Puccetti, C Lunardi, R Cimaz
Immune-mediated sensorineural hearing loss may complicate systemic autoimmune diseases. We have previously reported the presence of antibodies directed against inner ear antigens in patients with Cogan syndrome, a disease characterized by sudden hearing loss and interstitial keratitis. Such autoantibodies cross-react with an epitope of SSA/Ro60 protein. Anti-Ro/SSA antibodies in pregnant women cross the placenta and reach the fetal tissues inducing an immune-mediated damage of the cardiac conduction system...
December 2, 2016: Lupus
https://www.readbyqxmd.com/read/27904846/complete-congenital-heart-block-in-a-neonate-with-a-complex-congenital-heart-defect-in-africa
#2
Clovis Nkoke, Edvine Yonta Wawo, Liliane Kuate Mfeukeu, Larissa Makamte, Sandrine Dikosso Edie, Flore Esiene Balana
Congenital heart block (CHB) is rare disorder that has a higher mortality when associated with structural congenital heart defects. Very few cases have been reported in Sub-Saharan Africa (SSA). We present a case of complete CHB associated with a complex congenital heart defect in a neonate in Cameroon. A 1-month-old neonate in Cameroon was referred for the evaluation of bradycardia. The obstetrical ultrasound done during pregnancy revealed fetal bradycardia without further evaluation. Clinical examination showed well a developed neonate with bradycardia at 62 beats/minute, and mild cyanosis with oxygen saturation at 93% at room air...
October 2016: Cardiovascular Diagnosis and Therapy
https://www.readbyqxmd.com/read/27871127/effect-of-maternal-position-on-fetal-behavioural-state-and-heart-rate-variability-in-healthy-late-gestation-pregnancy
#3
Peter Stone, Wendy Burgess, Jordan McIntyre, Alistair Gunn, Christopher Lear, Laura Bennet, Edwin Mitchell, John Thompson
BACKGROUND: Fetal behavioural states (FBS) are measures of fetal wellbeing. In acute hypoxemia, the human fetus adapts to a lower oxygen consuming state with changes in the cardiotocograph and reduced fetal activity. Recent studies of late gestation stillbirth described the importance of sleep position in the risk of intrauterine death. We designed this study to assess the effects of different maternal positions on FBS in healthy late gestation pregnancies under controlled conditions...
November 21, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27728859/fluorinated-steroids-do-not-improve-outcome-of-isolated-atrioventricular-block
#4
N W E Van den Berg, M G Slieker, I M van Beynum, C M Bilardo, D de Bruijn, S A Clur, J M J Cornette, I M E Frohn-Mulder, M C Haak, K E H van Loo-Maurus, G T R Manten, A B M H Rackowitz, L A J Rammeloo, A Reimer, M E B Rijlaarsdam, M W Freund
INTRODUCTION: Congenital atrioventricular block (CAVB) is a rare disorder with a significant morbidity and mortality. Consensus regarding the prescription and efficacy of prenatal corticosteroids is lacking. This nationwide study was initiated to evaluate the effects of prenatal treatment with corticosteroids on the outcome of CAVB in The Netherlands. METHODS: All fetuses identified with isolated congenital AVB-II° or AVB-III° in any of the eight academic fetal heart centers of The Netherlands between 2003 and 2013 were included and reviewed...
September 30, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27692363/exogenous-melatonin-reduced-blood-pressure-in-late-term-ovine-fetus-via-mt1-mt2-receptor-pathways
#5
Jianying Tao, Juanxiu Lv, Weisheng Li, Pengjie Zhang, Caiping Mao, Zhice Xu
Melatonin is involved in the regulation of blood pressure through the receptor dependent or independent route. However, the effect of melatonin on fetal blood pressure is unknown. This study investigated the effect of melatonin on blood pressure of the late-term ovine fetus in utero. Melatonin and/or antagonists were intravenously administered into the fetuses. Mean arterial pressure and heart rate were recorded. Fetal blood samples were analyzed for biochemical parameters and hormones, including cortisol, angiotensin I, angiotensin II, aldosterone, atrial natriuretic peptide, corticotrophin-releasing hormone, adrenocorticotropic hormone, and endothelin...
September 2016: Reproductive Biology
https://www.readbyqxmd.com/read/27651588/correlation-of-maternal-autoantibodies-with-fetal-congenital-heart-block
#6
Dey Madhusudan, Agarwal Raju, Nambula Vijaya
BACKGROUND: Autoimmune fetal congenital heart block (CHB) is the most severe manifestation of neonatal lupus, and it is seen when maternal autoimmune antibodies cross the placenta and damage the AV node of the fetus. CHB is mainly associated with maternal SLE with anti-Ro/SSA- and anti-La/SSB-positive status, and incidence of CHB increases when both the antibodies are present. This study was conducted to know the incidence of fetal CHB in patients of SLE who had ANA, anti-Ro/SSA and anti-La/SSB positivity...
October 2016: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/27635094/outcome-of-pregnancy-in-patients-with-systemic-lupus-erythematosis-at-korle-bu-teaching-hospital
#7
Ida Dzifa Dey, Jerry Coleman, Harriet Kwarko, Michael Mate-Kole
OBJECTIVE: To study maternal and fetal outcomes in Ghanaian women with systemic lupus erythematosus (SLE). METHODS: Retrospective study of pregnancies in women with SLE in a single centre in Ghana. RESULTS: The mean age was 30.1 years and all were nulliparous. Two out of the seven pregnancies were in disease remission at the time of booking. Nephritis without renal impairment was present in 7 pregnancies (6 women). One woman developed intrapartum eclampsia...
June 2016: Ghana Medical Journal
https://www.readbyqxmd.com/read/27548532/identification-of-discrete-epitopes-of-ro52p200-and-association-with-fetal-cardiac-conduction-system-manifestations-in-a-rodent-model
#8
A Hoxha, A Ruffatti, A Ambrosi, V Ottosson, M Hedlund, L Ottosson, M Anandapadamanaban, M Sunnerhagen, S-E Sonesson, M Wahren-Herlenius
Congenital heart block (CHB) is a potentially lethal condition characterized by a third-degree atrioventricular block (AVB). Despite anti-Ro52 antibodies being detected in nearly 90% of mothers of affected children, CHB occurs in only 1-2% of anti-Ro/Sjögren's-syndrome-related antigen A (SSA) autoantibody-positive pregnancies. Maternal antibodies have been suggested to bind molecules crucial to fetal cardiac function; however, it remains unknown whether a single antibody profile associates with CHB or whether several specificities and cross-reactive targets exist...
December 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27279868/fetal-cardiac-interventions-clinical-and-experimental-research
#9
REVIEW
Shi-Min Yuan, Gulimila Humuruola
Fetal cardiac interventions for congenital heart diseases may alleviate heart dysfunction, prevent them evolving into hypoplastic left heart syndrome, achieve biventricular outcome and improve fetal survival. Candidates for clinical fetal cardiac interventions are now restricted to cases of critical aortic valve stenosis with evolving hypoplastic left heart syndrome, pulmonary atresia with an intact ventricular septum and evolving hypoplastic right heart syndrome, and hypoplastic left heart syndrome with an intact or highly restrictive atrial septum as well as fetal heart block...
2016: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/27274376/anesthetic-management-of-patient-with-sjogren-s-syndrome-who-underwent-cesarean-section-a-case-report
#10
Na Eun Kim, Jae Hyuk Lee, In Sun Chung, Jun Yong Lee
Sjogren's syndrome is one of the most common autoimmune disorders and has a female predominance. Maternal circulating autoantibodies such as anti-Ro/SSA and anti-La/SSB antibodies can cause congenital heart block of fetus, and in severe case, emergency pacemaker implantation may be needed for neonate. Therefore, it is very important to understand maternal and fetal condition and pay attention to the status of the neonate during delivery. In this paper, we present a case of patient with Sjogren's syndrome who underwent cesarean section under spinal anesthesia...
June 2016: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/27070743/physiological-role-of-fgf-signaling-in-growth-and-remodeling-of-developing-cardiovascular-system
#11
E Krejci, Z Pesevski, O Nanka, D Sedmera
Fibroblast growth factor (FGF) signaling plays an important role during embryonic induction and patterning, as well as in modulating proliferative and hypertrophic growth in fetal and adult organs. Hemodynamically induced stretching is a powerful physiological stimulus for embryonic myocyte proliferation. The aim of this study was to assess the effect of FGF2 signaling on growth and vascularization of chick embryonic ventricular wall and its involvement in transmission of mechanical stretch-induced signaling to myocyte growth in vivo...
July 18, 2016: Physiological Research
https://www.readbyqxmd.com/read/27033242/postnatal-outcome-of-fetal-left-ventricular-hypertrabeculation-noncompaction
#12
Claudia Stöllberger, Christian Wegner, Abraham Benatar, Thomas K Chin, Joanna Dangel, Danielle Majoor-Krakauer, Tapas K Mondal, Shanthi Sivanandam, Norman H Silverman, Jaap van Waning, Josef Finsterer
Left ventricular hypertrabeculation/noncompaction (LVHT) is a cardiac abnormality of unknown etiology. Prenatal diagnosis of LVHT can be established by fetal echocardiography. A review of 106 published cases showed that 46 cases with prenatally diagnosed LVHT were alive 0.5-120 months after birth. Since the course of cases with prenatally LVHT after publication is unknown, we aimed to collect follow-up-information. Information regarding vital status, cardiac and extracardiac morbidity was gathered by contacting the authors of the 46 cases...
June 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27026811/maternal-autoantibody-profiles-at-risk-for-autoimmune-congenital-heart-block-a-prospective-study-in-high-risk-patients
#13
Marta Tonello, Amelia Ruffatti, Maria Favaro, Tiziana Tison, Teresa Del Ross, Antonia Calligaro, Ariela Hoxha, Elena Mattia, Leonardo Punzi
OBJECTIVE: This prospective study aimed to identify antibody profiles characterising mothers with fetuses developing congenital heart block (CHB) by comparing their antibody frequencies and levels with those in unaffected mothers. METHODS: Eighty-one consecutive pregnant patients positive to anti-Ro±anti-La antibodies, at high risk of developing fetal CHB were prospectively studied. The 16 patients with fetal CHB outcome were considered the study population and the 65 patients with normal pregnancy outcomes were considered the control cohort...
2016: Lupus Science & Medicine
https://www.readbyqxmd.com/read/27021067/minimally-invasive-implantable-fetal-micropacemaker-mechanical-testing-and-technical-refinements
#14
Li Zhou, Adriana Nicholson Vest, Raymond A Peck, Jonathan P Sredl, Xuechen Huang, Yaniv Bar-Cohen, Michael J Silka, Jay D Pruetz, Ramen H Chmait, Gerald E Loeb
This paper discusses the technical and safety requirements for cardiac pacing of a human fetus with heart failure and hydrops fetalis secondary to complete heart block. Engineering strategies to meet specific technical requirements were integrated into a systematic design and implementation consisting of a novel fetal micropacemaker, a percutaneous implantation system, and a sterile package that enables device storage and recharging maintenance in a clinical setting. We further analyzed observed problems on myocardial fixation and pacing lead fatigue previously reported in earlier preclinical trials...
December 2016: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/26946331/ductus-venosus-doppler-in-the-assessment-of-fetal-cardiovascular-health-an-updated-practical-approach
#15
REVIEW
Viola Seravalli, Jena L Miller, Dana Block-Abraham, Ahmet A Baschat
The ductus venosus has a central role in the distribution of highly oxygenated umbilical venous blood to the heart. Its waveform is related to the pressure-volume changes in the cardiac atria and it is therefore important in the monitoring of any fetal condition that may affect forward cardiac function. The cardiovascular parameters that can influence forward cardiac function include afterload, myocardial performance and preload. Decreased forward flow during atrial systole (a-wave) is the most sensitive and ubiquitous finding when any of these parameters is affected...
June 2016: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/26918336/protective-effect-of-antenatal-antioxidant-on-nicotine-induced-heart-ischemia-sensitive-phenotype-in-rat-offspring
#16
DaLiao Xiao, Lei Wang, Xiaohui Huang, Yong Li, Chiranjib Dasgupta, Lubo Zhang
Fetal nicotine exposure increased risk of developing cardiovascular disease later in life. The present study tested the hypothesis that perinatal nicotine-induced programming of heart ischemia-sensitive phenotype is mediated by enhanced reactive oxygen species (ROS) in offspring. Nicotine was administered to pregnant rats via subcutaneous osmotic minipumps from day 4 of gestation to day 10 after birth, in the absence or presence of a ROS inhibitor, N-acetyl-cysteine (NAC) in drinking water. Experiments were conducted in 8 month old age male offspring...
2016: PloS One
https://www.readbyqxmd.com/read/26891440/-the-complications-of-systemic-sclerosis-in-pregnancy-diagnostic-and-therapeutic-difficulties
#17
REVIEW
Bogna Grygiel-Górniak, Mariusz Puszczewicz
In the course of scleroderma numerous complications may occur caused by the endothelial vessel changes and organs' fibrosis. Pregnancy itself is associated with increased immunization caused by the microchimerism phenomenon. Pregnancy may be associated with increased dyspnea, hypertension, gastroesophageal reflux disease (GERD), renal complications and mother pre-eclampsia. In turn, the most common disorders of the fetus include low birth weight, premature delivery and heart block. The occurrence of organ complications in the mother needs urgent gynecological and rheumatologic care, which often requires the consultation of pulmonologist, cardiologist, nephrologists and gastroenterologist...
January 2016: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/26876124/fetal-and-neonatal-arrhythmias
#18
REVIEW
Edgar Jaeggi, Annika Öhman
Cardiac arrhythmias are an important aspect of fetal and neonatal medicine. Premature complexes of atrial or ventricular origin are the main cause of an irregular heart rhythm. The finding is typically unrelated to an identifiable cause and no treatment is required. Tachyarrhythmia most commonly relates to supraventricular reentrant tachycardia, atrial flutter, and sinus tachycardia. Several antiarrhythmic agents are available for the perinatal treatment of tachyarrhythmias. Enduring bradycardia may result from sinus node dysfunction, complete heart block and nonconducted atrial bigeminy as the main arrhythmia mechanisms...
March 2016: Clinics in Perinatology
https://www.readbyqxmd.com/read/26872497/a-case-of-neonatal-lupus-erythematosus-in-a-very-low-birth-weight-infant-that-suffered-intraventricular-hemorrhage-at-birth
#19
Hirokazu Arai, Hatsushi Nakajima, Nao Ogino, Tomoo Ito, Ryoji Goto, Yurina Kameta, Natsuki Ono, Naoko Hosoya, Hiroyuki Sanada, Tsutomu Takahashi
This report describes the case of a very low-birth-weight male infant with neonatal lupus erythematosus. His mother had Sjögren's syndrome, and her previous child had suffered a complete heart block. Accordingly, maternal steroid (betamethasone) therapy was administered to prevent a congenital heart block for 15 weeks (from 13 to 27 weeks' gestation). At 28 weeks' gestation, the mother was weaned off the steroid therapy, and an emergency cesarean section was carried out at 29 weeks and 6 days' gestation because of a nonreassuring fetal status (NRFS)...
June 2, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/26835701/assessment-of-fluorinated-steroids-to-avert-progression-and-mortality-in-anti-ssa-ro-associated-cardiac-injury-limited-to-the-fetal-conduction-system
#20
Peter M Izmirly, Amit Saxena, Sara K Sahl, Ummara Shah, Deborah M Friedman, Mimi Y Kim, Jill P Buyon
OBJECTIVES: Extension of disease beyond the atrioventricular (AV) node is associated with increased mortality in cardiac neonatal lupus (NL). Treatment of isolated heart block with fluorinated steroids to prevent disease progression has been considered but published data are limited and discordant regarding efficacy. This study evaluated whether fluorinated steroids given to manage isolated advanced block prevented development of disease beyond the AV node and conferred a survival benefit...
June 2016: Annals of the Rheumatic Diseases
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