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https://www.readbyqxmd.com/read/29328369/pitx2-dna-methylation-predicts-response-to-anthracycline-based-adjuvant-chemotherapy-in-triple-negative-breast-cancer-patients
#1
Magdalena Absmaier, Rudolf Napieralski, Tibor Schuster, Michaela Aubele, Axel Walch, Viktor Magdolen, Julia Dorn, Eva Gross, Nadia Harbeck, Aurelia Noske, Marion Kiechle, Manfred Schmitt
Triple-negative breast cancer (TNBC) constitutes a heterogeneous breast cancer subgroup with poor prognosis; survival rates are likely to be lower with TNBC compared to other breast cancer subgroups. For this disease, systemic adjuvant chemotherapy regimens often yield suboptimal clinical results. To improve treatment regimens in TNBC, identification of molecular biomarkers may help to select patients for individualized adjuvant therapy. Evidence has accumulated that determination of the methylation status of the PITX2 gene provides a predictive value in various breast cancer subgroups, either treated with endocrine-based therapy or anthracycline-containing chemotherapy...
January 8, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/29323464/light-driven-shape-memory-porous-films-with-precisely-controlled-dimensions
#2
Wei Wang, Dingfeng Shen, Xiao Li, Yuan Yao, Jiaping Lin, Aurelia Wang, Jiwoo Yu, Zhonglin Wang, Suck Won Hong, Shaoliang Lin, Zhiqun Lin
Here we report an unconventional strategy for crafting light-driven shape memory porous films (SMPFs) by judiciously constructing highly ordered porous films via a facile "breath figure" approach, followed by sequential vapor crosslinking and nondestructive directional light manipulation. The latter can conveniently and precisely transform round micropores into other shapes including round-rectangle, round-rhombus and size-reduced micropores at room temperature. Importantly, the transformed micropores can be perfectly reverted to original shapes by either thermal annealing or UV irradiation...
January 11, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29318681/shape-memory-polymers-for-body-motion-energy-harvesting-and-self-powered-mechanosensing
#3
Ruiyuan Liu, Xiao Kuang, Jianan Deng, Yi-Cheng Wang, Aurelia C Wang, Wenbo Ding, Ying-Chih Lai, Jun Chen, Peihong Wang, Zhiqun Lin, H Jerry Qi, Baoquan Sun, Zhong Lin Wang
Growing demand in portable electronics raises a requirement to electronic devices being stretchable, deformable, and durable, for which functional polymers are ideal choices of materials. Here, the first transformable smart energy harvester and self-powered mechanosensation sensor using shape memory polymers is demonstrated. The device is based on the mechanism of a flexible triboelectric nanogenerator using the thermally triggered shape transformation of organic materials for effectively harvesting mechanical energy...
January 10, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29314183/fixed-dosing-of-intravenous-tocilizumab-in-rheumatoid-arthritis-results-from-a-population-pharmacokinetic-analysis
#4
Carla Bastida, Virginia Ruiz-Esquide, Mariona Pascal, Aurelia H M de Vries Schultink, Jordi Yagüe, Raimon Sanmartí, Alwin D R Huitema, Dolors Soy
AIM: Intravenous tocilizumab is currently dosed on body weight although a weak correlation between body weight and clearance has been described. The aim of the study was to assess the current dosing strategy and provide a scientific rational for dosing using a modeling and simulation approach. METHODS: Serum concentrations and covariates were obtained from intravenous tocilizumab treated subjects at a dose of 4, 6 or 8 mg every 28 days. A population pharmacokinetic analysis was performed using nonlinear mixed effects modeling...
January 4, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29290628/the-role-of-sirt6-in-tumors
#5
EDITORIAL
Vanessa Desantis, Aurelia Lamanuzzi, Angelo Vacca
No abstract text is available yet for this article.
January 2018: Haematologica
https://www.readbyqxmd.com/read/29285256/investigation-of-rip140-and-lcor-as-independent-markers-for-poor-prognosis-in-cervical-cancer
#6
Aurelia Vattai, Vincent Cavailles, Sophie Sixou, Susanne Beyer, Christina Kuhn, Mina Peryanova, Helene Heidegger, Kerstin Hermelink, Doris Mayr, Sven Mahner, Christian Dannecker, Udo Jeschke, Bernd Kost
Introduction: RIP140 (Receptor Interacting Protein) is involved in the regulation of oncogenic signaling pathways and in the development of breast and colon cancers. The aim of the study was to analyze the expression of RIP140 and its partner LCoR in cervical cancers, to decipher their relationship with histone protein modifications and to identify a potential link with patient survival. Methods: Immunohistochemical analyses were carried out to quantify RIP140 and LCoR expression in formalin-fixed paraffin-embedded tissue sections cervical cancer samples...
December 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/29281657/indoles-induce-metamorphosis-in-a-broad-diversity-of-jellyfish-but-not-in-a-crown-jelly-coronatae
#7
Rebecca R Helm, Casey W Dunn
Many animals go through one or more metamorphoses during their lives, however, the molecular underpinnings of metamorphosis across diverse species are not well understood. Medusozoa (Cnidaria) is a clade of animals with complex life cycles, these life cycles can include a polyp stage that metamorphoses into a medusa (jellyfish). Medusae are produced through a variety of different developmental mechanisms-in some species polyps bud medusae (Hydrozoa), in others medusae are formed through polyp fission (Scyphozoa), while in others medusae are formed through direct transformation of the polyp (Cubozoa)...
2017: PloS One
https://www.readbyqxmd.com/read/29281085/increase-of-proteasome-and-papain-like-cysteine-protease-activities-in-autophagy-mutants-backup-compensatory-effect-or-pro-cell-death-effect
#8
Marien Havé, Thierry Balliau, Betty Cottyn-Boitte, Emeline Dérond, Gwendal Cueff, Fabienne Soulay, Aurélia Lornac, Pavel Reichman, Nico Dissmeyer, Jean-Christophe Avice, Patrick Gallois, Loïc Rajjou, Michel Zivy, Céline Masclaux-Daubresse
Autophagy is essential for protein degradation, nutrient recycling and nitrogen remobilization. Autophagy is induced during leaf ageing and in response to nitrogen starvation and was shown to play a fundamental role in nutrient recycling for remobilization and seed filling. Accordingly, ageing leaves of Arabidopsis autophagy mutants (atg) were shown to over-accumulate proteins and peptides, possibly because of a reduced protein degradation capacity. Surprisingly, atg leaves also displayed higher protease activities...
December 21, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29273369/carbon-monoxide-and-hydrogen-sulphide-reduce-reperfusion-injury-in-abdominal-compartment-syndrome
#9
Patrick B Murphy, Aurelia Bihari, Neil G Parry, Ian Ball, Ken Leslie, Kelly Vogt, Abdel-Rahman Lawendy
BACKGROUND: Carbon monoxide (CO)- and hydrogen sulphide-releasing molecules (CORM-3 and GYY4137, respectively) have been shown to be potent antioxidant and antiinflammatory agents at the tissue and systemic level. We hypothesized that both CORM-3 and GYY4137 would reduce the significant organ dysfunction associated with abdominal compartment syndrome (ACS). MATERIAL AND METHODS: Randomized trial was conducted where ACS was maintained for 2 hours in 27 rats using an abdominal plaster cast and intraperitoneal CO2 insufflation at 20 mmHg...
February 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29250693/non-hodgkin-s-lymphoma-rare-localization-at-the-base-of-the-tongue-case-presentation
#10
Daniel Mirea, Liliana Elena Mirea, Cornelia Nitipir, Mirela Ţigliş, Ioana Cristina GrinŢescu, Tiberiu Paul Neagu, Carmen Aurelia Mogoantă, Ioana Marina GrinŢescu
The extranodal malignant lymphomas occur mainly in the region of the head and neck, after the gastrointestinal tract. The most common site of the head and neck lymphoma is at the lymphatics ring of Waldeyer, followed by the nasosinusal region. Localization at the base of the tongue is extremely rare. The authors reported a case of a 50-year-old male with a non-Hodgkin's lymphoma, which developed at the base of tongue. An unusual sensation described as a foreign body at the hypopharyngeal region associated with progressive dysphagia were the main symptoms for which the patient was referred to our Hospital...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29250657/streptococcal-tonsillitis-related-reactive-arthritis-clinical-ultrasound-imaging-and-immunohistochemical-study
#11
Anca Emanuela Muşetescu, Marius Florea, Mircea Cătălin ForŢofoiu, Ana Maria Bumbea, Andreea Daniela Tudorancea, Cristina Criveanu, Cristina Elena GofiŢă, Paulina Lucia Ciurea, Alexandru Ştefănescu, Ştefan Cristian Dinescu, Carmen Aurelia Mogoantă
In clinical practice and literature studies, the most common condition associated to streptococcal tonsillitis used to be acute rheumatic fever (ARF). Several publications in the late years report a more frequent and distinctive entity from ARF following β-hemolytic group A streptococcus infection in patients with post-infectious arthritis, that do not fulfill the modified Jones criteria, the so-called post-streptococcal reactive arthritis (PSRA). A distinctive pattern of clinical framing and biological profile in patients with PSRA following streptococcal tonsillitis is described, with a non-migratory, additive, recent onset (7-10 days) arthritis that affects small and large joints as well, with a bimodal peak of incidence at 8-14 and 21-37 years of age, with variate response to non-steroidal anti-inflammatory drugs and has a tendency for recurrence and persistence...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29249005/metronomic-capecitabine-as-second-line-treatment-for-hepatocellular-carcinoma-after-sorafenib-discontinuation
#12
Franco Trevisani, Giovanni Brandi, Francesca Garuti, Maria Aurelia Barbera, Raffaella Tortora, Andrea Casadei Gardini, Alessandro Granito, Francesco Tovoli, Stefania De Lorenzo, Andrea Lorenzo Inghilesi, Francesco Giuseppe Foschi, Mauro Bernardi, Fabio Marra, Rodolfo Sacco, Giovan Giuseppe Di Costanzo
PURPOSE: Metronomic capecitabine (MC) is a well-tolerated systemic treatment showing promising results in one retrospective study, as second-line therapy after sorafenib failure, in patients with hepatocellular carcinoma (HCC). METHODS: 117 patients undergoing MC were compared to 112 patients, eligible for this treatment, but undergoing best supportive care (BSC) after sorafenib discontinuation for toxicity or HCC progression. The two groups were compared for demographic and clinical features...
December 16, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29247022/preventing-fractures-in-the-masters-athlete-we-can-do-better
#13
EDITORIAL
Amy P Powell, Lauren Borowski, Andrea Kussman, Aurelia Nattiv
No abstract text is available yet for this article.
December 15, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29233559/tumour-infiltrating-lymphocytes-and-prognosis-in-different-subtypes-of-breast-cancer-a-pooled-analysis-of-3771-patients-treated-with-neoadjuvant-therapy
#14
Carsten Denkert, Gunter von Minckwitz, Silvia Darb-Esfahani, Bianca Lederer, Barbara I Heppner, Karsten E Weber, Jan Budczies, Jens Huober, Frederick Klauschen, Jenny Furlanetto, Wolfgang D Schmitt, Jens-Uwe Blohmer, Thomas Karn, Berit M Pfitzner, Sherko Kümmel, Knut Engels, Andreas Schneeweiss, Arndt Hartmann, Aurelia Noske, Peter A Fasching, Christian Jackisch, Marion van Mackelenbergh, Peter Sinn, Christian Schem, Claus Hanusch, Michael Untch, Sibylle Loibl
BACKGROUND: Tumour-infiltrating lymphocytes (TILs) are predictive for response to neoadjuvant chemotherapy in triple-negative breast cancer (TNBC) and HER2-positive breast cancer, but their role in luminal breast cancer and the effect of TILs on prognosis in all subtypes is less clear. Here, we assessed the relevance of TILs for chemotherapy response and prognosis in patients with TNBC, HER2-positive breast cancer, and luminal-HER2-negative breast cancer. METHODS: Patients with primary breast cancer who were treated with neoadjuvant combination chemotherapy were included from six randomised trials done by the German Breast Cancer Group...
December 7, 2017: Lancet Oncology
https://www.readbyqxmd.com/read/29227932/an-overview-of-natural-antimicrobials-role-in-food
#15
REVIEW
Aurelia Magdalena Pisoschi, Aneta Pop, Cecilia Georgescu, Violeta Turcuş, Neli Kinga Olah, Endre Mathe
The present paper aims to review the natural food preservatives with antimicrobial properties emphasizing their importance for the future of food manufacturing and consumers' health. The extraction procedures applied to natural antimicrobials will be considered, followed by the description of some natural preservatives' antimicrobial mechanism of action, including (i) membrane rupture with ATP-ase activity inhibition, (ii) leakage of essential biomolecules from the cell, (iii) disruption of the proton motive force and (iiii) enzyme inactivation...
December 2, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29223456/simplex-optimization-of-the-variables-influencing-the-determination-of-pefloxacin-by-time-resolved-chemiluminescence
#16
José A Murillo Pulgarín, Aurelia Alañón Molina, Elisa Jiménez García
A new chemiluminescence (CL) detection system combined with flow injection analysis (FIA) for the determination of Pefloxacin is proposed. The determination is based on an energy transfer from Pefloxacin to terbium (III). The metal ion enhances the weak CL signal produced by the KMnO4/H2SO3/Pefloxacin system. A modified simplex method was used to optimize chemical and instrumental variables. The influence of the interaction of the permanganate, Tb (III), sodium sulphite and sulphuric acid concentrations, flow rate and injected sample volume was thoroughly investigated by using a modified simplex optimization procedure...
December 5, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29191980/prior-automatic-posture-and-activity-identification-improves-physical-activity-energy-expenditure-prediction-from-hip-worn-triaxial-accelerometry
#17
Maël Garnotel, Thomas Bastian, Hector-Manuel Romero-Ugalde, Aurélia Maire, Julien Dugas, Alexandre Zahariev, Maeva Doron, Pierre Jallon, Guillaume Charpentier, Sylvia Franc, Stéphane Blanc, Stéphane Bonnet, Chantal Simon
Accelerometry is increasingly used to quantify physical activity (PA) and related energy expenditure (EE). Linear regression models designed to derive PAEE from accelerometry-counts have shown their limits, mostly due to the lack of consideration of the nature of activities performed. Here we tested whether a model coupling an automatic activity/posture recognition (AAR) algorithm with an activity-specific count-based model, developed in 61 subjects in laboratory conditions, improved PAEE and total EE (TEE) predictions from hip-worn triaxial-accelerometer (ActigraphGT3X+TM) in free-living conditions...
November 30, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29185601/adherence-to-central-venous-catheter-insertion-bundle-in-neonatal-and-pediatric-units
#18
Fernanda Lopes de Araújo, Bruna Figueiredo Manzo, Anna Caroline Leite Costa, Allana Dos Reis Corrêa, Juliana de Oliveira Marcatto, Delma Aurélia da Silva Simão
OBJECTIVE: To describe the observed behavior of professionals in two neonatal and pediatric intensive care units regarding the use of central venous catheter insertion bundle, and the clinical and birth profile of neonates and children who received the devices. METHOD: A quantitative descriptive exploratory study was conducted in two intensive care units of a public hospital in Belo Horizonte with neonates and children, between February and September 2016. RESULTS: The sample consisted of 59 observed implants of central venous catheter...
November 27, 2017: Revista da Escola de Enfermagem da U S P
https://www.readbyqxmd.com/read/29178447/phenotype-and-genotype-analysis-of-a-french-cohort-of-119-patients-with-charge-syndrome
#19
Marine Legendre, Véronique Abadie, Tania Attié-Bitach, Nicole Philip, Tiffany Busa, Dominique Bonneau, Estelle Colin, Hélène Dollfus, Didier Lacombe, Annick Toutain, Sophie Blesson, Sophie Julia, Dominique Martin-Coignard, David Geneviève, Bruno Leheup, Sylvie Odent, Pierre-Simon Jouk, Sandra Mercier, Laurence Faivre, Catherine Vincent-Delorme, Christine Francannet, Sophie Naudion, Michèle Mathieu-Dramard, Marie-Ange Delrue, Alice Goldenberg, Delphine Héron, Philippe Parent, Renaud Touraine, Valérie Layet, Damien Sanlaville, Chloé Quélin, Sébastien Moutton, Mélanie Fradin, Aurélia Jacquette, Sabine Sigaudy, Lucile Pinson, Pierre Sarda, Anne-Marie Guerrot, Massimiliano Rossi, Alice Masurel-Paulet, Salima El Chehadeh, Xavier Piguel, Montserrat Rodriguez-Ballesteros, Stéphanie Ragot, Stanislas Lyonnet, Frédéric Bilan, Brigitte Gilbert-Dussardier
CHARGE syndrome (CS) is a genetic disorder whose first description included Coloboma, Heart disease, Atresia of choanae, Retarded growth and development, Genital hypoplasia, and Ear anomalies and deafness, most often caused by a genetic mutation in the CHD7 gene. Two features were then added: semicircular canal anomalies and arhinencephaly/olfactory bulb agenesis, with classification of typical, partial, or atypical forms on the basis of major and minor clinical criteria. The detection rate of a pathogenic variant in the CHD7 gene varies from 67% to 90%...
November 27, 2017: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/29172141/new-sensor-based-on-membranes-with-magnetic-nano-inclusions-for-early-diagnosis-in-periodontal-disease
#20
Eugenia Eftimie Totu, Ibrahim Isildak, Aurelia Cristina Nechifor, Corina Marilena Cristache, Marius Enachescu
A series of sodium selective membranes with magnetic nano-inclusions using p-tertbutyl calix[4]arene as ionophore and polymeric matrix (polyvinyl chloride) have been developed, and the corresponding sodium selective sensors were obtained for the first time. A linear range was registered between 3.1 × 10(-5) and 10(-1)moldm(-3) and near Nernstian electrochemical answer: 55.73mV/decade has been recoreded for PVC (polyvinyl chloride) - based sodium selective sensor, with a response time of 45s. Due to their small dimensions, sensors could be used for measuring ions from the gingival crevicular fluid directly into the peri-odontal pocket, avoiding the difficulties of collecting an appropriate amount of fluid for analysis...
November 21, 2017: Biosensors & Bioelectronics
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