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https://www.readbyqxmd.com/read/28446146/flow-cytometry-sorting-of-nuclei-enables-the-first-global-characterization-of-paramecium-germline-dna-and-transposable-elements
#1
Frédéric Guérin, Olivier Arnaiz, Nicole Boggetto, Cyril Denby Wilkes, Eric Meyer, Linda Sperling, Sandra Duharcourt
BACKGROUND: DNA elimination is developmentally programmed in a wide variety of eukaryotes, including unicellular ciliates, and leads to the generation of distinct germline and somatic genomes. The ciliate Paramecium tetraurelia harbors two types of nuclei with different functions and genome structures. The transcriptionally inactive micronucleus contains the complete germline genome, while the somatic macronucleus contains a reduced genome streamlined for gene expression. During development of the somatic macronucleus, the germline genome undergoes massive and reproducible DNA elimination events...
April 26, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28440548/contact-sensitizers-trigger-human-cd1-autoreactive-t-cell-responses
#2
Richard J Betts, Adrijana Perkovic, Subhashree Mahapatra, Aurélia Del Bufalo, Kaddy Camara, Amy R Howell, Silvia Martinozzi Teissier, Gennaro De Libero, Lucia Mori
Allergic contact dermatitis is a primarily T-cell-mediated inflammatory skin disease induced by exposure to small molecular-weight haptens, which covalently bind to proteins. The abundance of cutaneous T cells that recognize CD1a antigen-presenting molecules raises the possibility that MHC-independent antigen presentation may be relevant in some hapten-driven immune responses. Here we examine the ability of contact sensitizers to influence CD1-restricted immunity. Exposure of human antigen-presenting cells such as monocyte-derived dendritic cells and THP-1 cells to the prototypical contact sensitizer dinitrochlorobenzene potentiated the response of CD1a- and CD1d-autoreactive T cells, which released a vast array of cytokines in a CD1- and TCR-dependent manner...
April 25, 2017: European Journal of Immunology
https://www.readbyqxmd.com/read/28437272/review-of-effectiveness-of-an-integrated-video-recording-and-replaying-system-in-robotic-surgical-training-by-yang-k-perez-m-hubert-n-hossu-g-perrenot-c-hubert-j-in-ann-surg-265-521-526-2017
#3
Vishwanath Chegireddy, Aurelia T Perdanasari, Larry H Hollier
No abstract text is available yet for this article.
April 21, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28433113/wilson-disease-brain-pathology
#4
Aurélia Poujois, Jacqueline Mikol, France Woimant
In Wilson disease (WD), brain cellular damage is thought to be due to copper deposition. Striatal lesions are the most characteristic lesions found in the brain of patients with neurologic symptoms, as emphasized in the initial reports of S.A.K. Wilson. WD brain lesions can be more diffuse, including in the pons, midbrain, thalamus, dentate nucleus, and, less frequently, corpus callosum and cortex. In rare cases, extensive cortical-subcortical lesions have been reported. Increased cellularity is noted in the lesions due to the proliferation of modified astrocytes named Alzheimer types of glia and specific cells, called Opalski cells, that are characteristic of WD...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/28409272/increased-trace-amine-associated-receptor-1-taar1-expression-is-associated-with-a-positive-survival-rate-in-patients-with-breast-cancer
#5
Aurelia Vattai, Elif Akyol, Christina Kuhn, Simone Hofmann, Helene Heidegger, Franz von Koch, Kerstin Hermelink, Rachel Wuerstlein, Nadia Harbeck, Doris Mayr, Christine Spitzweg, Bettina Toth, Sven Mahner, Udo Jeschke, Nina Ditsch
PURPOSE: A correlation between breast cancer and thyroid disorders has been described in previous studies. Degraded thyroid hormones are referred to as trace amines. These endogenous amines have the ability to bind to the G-protein-coupled receptor TAAR1 (trace amine-associated receptor) and thereby activate it. TAAR1 is able to modulate the serotonergic and dopaminergic system in the brain and has so far been studied in the neurological field. The following study represents the first investigation of the regulation of TAAR1 in primary breast cancer (no metastases, M0)...
April 13, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28404981/characterization-of-the-transcriptional-and-metabolic-responses-of-pediatric-high-grade-gliomas-to-mtor-hif-1a-axis-inhibition
#6
Aurélia Nguyen, François Marie Moussallieh, Alan Mackay, A Ercument Cicek, Andres Coca, Marie Pierre Chenard, Noelle Weingertner, Benoit Lhermitte, Eric Letouzé, Eric Guérin, Erwan Pencreach, Sarah Jannier, Dominique Guenot, Izzie Jacques Namer, Chris Jones, Natacha Entz-Werlé
Pediatric high grade glioma (pHGGs), including sus-tentorial and diffuse intrinsic pontine gliomas, are known to have a very dismal prognosis. For instance, even an increased knowledge on molecular biology driving this brain tumor entity, there is no treatment able to cure those patients. Therefore, we were focusing on a translational pathway able to increase the cell resistance to treatment and to reprogram metabolically tumor cells, which are, then, adapting easily to a hypoxic microenvironment. To establish, the crucial role of the hypoxic pathways in pHGGs, we, first, assessed their protein and transcriptomic deregulations in a pediatric cohort of pHGGs and in pHGG's cell lines, cultured in both normoxic and hypoxic conditions...
March 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28399189/the-choice-of-the-anchoring-protein-influences-the-interaction-of-recombinant-bacillus-spores-with-the-immune-system
#7
Aurelia Piekarska, Paulina Pełka, Grażyna Peszyńska-Sularz, Alessandro Negri, Krzysztof Hinc, Michał Obuchowski, Adam Iwanicki
The technology of display of heterologous proteins on the surface of Bacillus subtilis spores enables use of these structures as carriers of antigens for mucosal vaccination. Currently, there are no technical possibilities to predict whether a designed fusion will be efficiently displayed on the spore surface and how such recombinant spores will interact with cells of the immune system. In this study, we compared four variants of B. subtilis spores presenting a fragment of a FliD protein from Clostridium difficile in fusion with CotB, CotC, CotG or CotZ spore coat proteins...
April 12, 2017: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/28397697/nab-paclitaxel-plus-either-gemcitabine-or-simplified-leucovorin-and-fluorouracil-as-first-line-therapy-for-metastatic-pancreatic-adenocarcinoma-afugem-gercor-a-non-comparative-multicentre-open-label-randomised-phase-2-trial
#8
Jean-Baptiste Bachet, Pascal Hammel, Jérôme Desramé, Aurélia Meurisse, Benoist Chibaudel, Thierry André, Philippe Debourdeau, Jérome Dauba, Thierry Lecomte, Jean-François Seitz, Christophe Tournigand, Thomas Aparicio, Véronique Guerin Meyer, Julien Taieb, Julien Volet, Amandine Monier, Franck Bonnetain, Christophe Louvet
BACKGROUND: Nab-paclitaxel plus gemcitabine has become a standard treatment regimen in patients with metastatic pancreatic adenocarcinoma; however, retrospective data suggest that gemcitabine might be inefficient in 50-60% of patients and thus not an optimum regimen in combination with nab-paclitaxel. We did a phase 2 trial to assess the activity and safety of a new regimen of nab-paclitaxel plus simplified leucovorin and fluorouracil. METHODS: We did a non-comparative, multicentre, open-label, randomised phase 2 trial in 15 hospitals and institutions in France...
May 2017: Lancet. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28397304/enhanced-performance-of-a-self-powered-organic-inorganic-photodetector-by-pyro-phototronic-and-piezo-phototronic-effects
#9
Wenbo Peng, Xingfu Wang, Ruomeng Yu, Yejing Dai, Haiyang Zou, Aurelia C Wang, Yongning He, Zhong Lin Wang
Self-powered photodetectors (PDs) have long been realized by utilizing photovoltaic effect and their performances can be effectively enhanced by introducing the piezo-phototronic effect. Recently, a novel pyro-phototronic effect is invented as an alternative approach for performance enhancement of self-powered PDs. Here, a self-powered organic/inorganic PD is demonstrated and the influences of externally applied strain on the pyro-phototronic and the photovoltaic effects are thoroughly investigated. Under 325 nm 2...
April 11, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28396677/gametocidal-factor-transferred-from-aegilops-geniculata-roth-can-be-adapted-for-large-scale-chromosome-manipulations-in-cereals
#10
Michał T Kwiatek, Halina Wiśniewska, Aurelia Ślusarkiewicz-Jarzina, Joanna Majka, Maciej Majka, Jolanta Belter, Hanna Pudelska
Segregation distorters are curious, evolutionarily selfish genetic elements, which distort Mendelian segregation in their favor at the expense of others. Those agents include gametocidal factors (Gc), which ensure their preferential transmission by triggering damages in cells lacking them via chromosome break induction. Hence, we hypothesized that the gametocidal system can be adapted for chromosome manipulations between Triticum and Secale chromosomes in hexaploid triticale (×Triticosecale Wittmack). In this work we studied the little-known gametocidal action of a Gc factor located on Aegilops geniculata Roth chromosome 4M(g)...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28388360/molecular-characterization-of-aspartylglucosaminidase-a-lysosomal-hydrolase-upregulated-during-strobilation-in-the-moon-jellyfish-aurelia-aurita
#11
Natsumi Tsujita, Hiroyuki Kuwahara, Hiroki Koyama, Noriyuki Yanaka, Kenji Arakawa, Hisato Kuniyoshi
The life cycle of the moon jellyfish, Aurelia aurita, alternates between a benthic asexual polyp stage and a planktonic sexual medusa (jellyfish) stage. Transition from polyp to medusa is called strobilation. To investigate the molecular mechanisms of strobilation, we screened for genes that are upregulated during strobilation using the differential display method and we identified aspartylglucosaminidase (AGA), which encodes a lysosomal hydrolase. Similar to AGAs from other species, Aurelia AGA possessed an N-terminal signal peptide and potential N-glycosylation sites...
May 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28383673/overall-survival-prediction-and-usefulness-of-second-line-chemotherapy-in-advanced-pancreatic-adenocarcinoma
#12
Angélique Vienot, Guillaume Beinse, Christophe Louvet, Louis de Mestier, Aurélia Meurisse, Francine Fein, Bruno Heyd, Denis Cleau, Christelle d'Engremont, Anne-Claire Dupont-Gossart, Zaher Lakkis, Christophe Tournigand, Olivier Bouché, Benoît Rousseau, Cindy Neuzillet, Franck Bonnetain, Christophe Borg, Dewi Vernerey
Background: In advanced pancreatic ductal adenocarcinoma (aPDAC), there is no consensual strategy for second-line chemotherapy (L2). Better discrimination of overall survival (OS) may help clinical decision-making. We aimed to predict OS from the beginning of L2 and to assess the benefit from chemotherapy among the identified risk groups. Methods: Analyses were derived from all consecutive aPDAC patients treated at Besancon University Hospital, Besancon, France, between January 2003 and December 2013 (n = 462)...
April 4, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28381550/clinical-and-genetic-spectrum-of-bartter-syndrome-type-3
#13
Elsa Seys, Olga Andrini, Mathilde Keck, Lamisse Mansour-Hendili, Pierre-Yves Courand, Christophe Simian, Georges Deschenes, Theresa Kwon, Aurélia Bertholet-Thomas, Guillaume Bobrie, Jean Sébastien Borde, Guylhène Bourdat-Michel, Stéphane Decramer, Mathilde Cailliez, Pauline Krug, Paul Cozette, Jean Daniel Delbet, Laurence Dubourg, Dominique Chaveau, Marc Fila, Noémie Jourde-Chiche, Bertrand Knebelmann, Marie-Pierre Lavocat, Sandrine Lemoine, Djamal Djeddi, Brigitte Llanas, Ferielle Louillet, Elodie Merieau, Maria Mileva, Luisa Mota-Vieira, Christiane Mousson, François Nobili, Robert Novo, Gwenaëlle Roussey-Kesler, Isabelle Vrillon, Stephen B Walsh, Jacques Teulon, Anne Blanchard, Rosa Vargas-Poussou
Bartter syndrome type 3 is a clinically heterogeneous hereditary salt-losing tubulopathy caused by mutations of the chloride voltage-gated channel Kb gene (CLCNKB), which encodes the ClC-Kb chloride channel involved in NaCl reabsorption in the renal tubule. To study phenotype/genotype correlations, we performed genetic analyses by direct sequencing and multiplex ligation-dependent probe amplification and retrospectively analyzed medical charts for 115 patients with CLCNKB mutations. Functional analyses were performed in Xenopus laevis oocytes for eight missense and two nonsense mutations...
April 5, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28364919/vaccine-stockouts-around-the-world-are-essential-vaccines-always-available-when-needed
#14
Patrick Lydon, Benjamin Schreiber, Aurelia Gasca, Laure Dumolard, Daniela Urfer, Kamel Senouci
INTRODUCTION: As countries rise to the challenge of implementing the priorities of this "Decade of Vaccine" and their commitments delineated in the Global Vaccine Action Plan (GVAP), many continue to face important challenges of securing a continuous supply of essential vaccine for their national immunization programme. This study provides evidence on the incidence of vaccine stockouts in countries, their root causes and their potential impact on service delivery. METHODS: Vaccine stockout indicators collected from the WHO-UNICEF Joint Reporting Form (JRF) and UNICEF's Vaccine Forecasting Tool were analysed for the years covering the first half of the GVAP (2011 to 2015) and using 2010 as the baseline year...
April 19, 2017: Vaccine
https://www.readbyqxmd.com/read/28343460/new-methods-of-morphometric-analyses-on-scyphozoan-jellyfish-statoliths-including-the-first-direct-evidence-for-statolith-growth-using-calcein-as-a-fluorescent-marker
#15
Ilka Sötje, Tamar Dishon, Frank Hoffmann, Sabine Holst
Statoliths are the only hard structures in the gelatinous bell of most scyphozoan medusae and investigations on these structures could promote investigations of the understudied population dynamics and phylogeny of jellyfish. We examined the statoliths of Aurelia aurita jellyfish of different ages by light microscopic and microtomographic measurements supplemented by scanning electron microscopy. The morphometric analyses confirmed that statolith numbers and sizes increase during jellyfish development and revealed that newly-formed statoliths had similar shapes that may change during statolith growth...
March 27, 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/28335173/mid-term-results-of-femoro-popliteal-stenting-for-chronic-critical-ischemia
#16
Aurélia Bianchini, Damien Labbe, Hovan Chenorhokian, Céline Perot-Millet, David Massouille
No abstract text is available yet for this article.
January 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28335171/mid-term-results-of-femoro-popliteal-stenting-among-patients-presenting-early-atheromatous-lesions-of-the-lower-extremities
#17
Damien Labbe, Aurélia Bianchini, Céline Perot, Hélène Wattez, David Massouille
No abstract text is available yet for this article.
January 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28334824/annexin-a2-links-poor-myofiber-repair-with-inflammation-and-adipogenic-replacement-of-the-injured-muscle
#18
Aurelia Defour, Sushma Medikayala, Jack H Van der Meulen, Marshall W Hogarth, Nicholas Holdreith, Apostolos Malatras, William Duddy, Jessica Boehler, Kanneboyina Nagaraju, Jyoti K Jaiswal
Repair of skeletal muscle after sarcolemmal damage involves dysferlin and dysferlin-interacting proteins such as annexins. Mice and patient lacking dysferlin exhibit chronic muscle inflammation and adipogenic replacement of the myofibers. Here we show that similar to dysferlin, lack of annexin A2 (AnxA2) also results in poor myofiber repair and progressive muscle weakening with age. By longitudinal analysis of AnxA2-deficient muscle we find that poor myofiber repair due to the lack of AnxA2 does not result in chronic inflammation or adipogenic replacement of the myofibers...
February 21, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28329758/lactb-is-a-tumour-suppressor-that-modulates-lipid-metabolism-and-cell-state
#19
Zuzana Keckesova, Joana Liu Donaher, Jasmine De Cock, Elizaveta Freinkman, Susanne Lingrell, Daniel A Bachovchin, Brian Bierie, Verena Tischler, Aurelia Noske, Marian C Okondo, Ferenc Reinhardt, Prathapan Thiru, Todd R Golub, Jean E Vance, Robert A Weinberg
Post-mitotic, differentiated cells exhibit a variety of characteristics that contrast with those of actively growing neoplastic cells, such as the expression of cell-cycle inhibitors and differentiation factors. We hypothesized that the gene expression profiles of these differentiated cells could reveal the identities of genes that may function as tumour suppressors. Here we show, using in vitro and in vivo studies in mice and humans, that the mitochondrial protein LACTB potently inhibits the proliferation of breast cancer cells...
March 22, 2017: Nature
https://www.readbyqxmd.com/read/28327832/-frequency-of-metabolic-syndrome-in-residents-of-an-andean-region-in-peru
#20
Juana Aurelia Ninatanta-Ortiz, Luz Amparo Núñez-Zambrano, Segunda Aydeé García-Flores, Franco Romaní Romaní
Objectives.: To calculate the frequency of metabolic syndrome (MetS) and its associated characteristics in selected populations residing in the urban areas of two districts in the Cajamarca region. Materials and methods.: Cross-sectional study performed in 2014, obtaining randomized samples from three target study populations: high school students, university students, and schoolchildren mothers. In adults, MetS was defined by means of Third Adult Treatment Panel (ATP III) criteria, and in teenagers, the modified Cook criteria were used...
October 2016: Revista Peruana de Medicina Experimental y Salud Pública
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