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https://www.readbyqxmd.com/read/28935577/human-pancreatic-acinar-cells-proteomic-characterization-physiologic-responses-and-organellar-disorders-in-ex-vivo-pancreatitis
#1
Aurelia Lugea, Richard T Waldron, Olga A Mareninova, Natalia Shalbueva, Nan Deng, Hsin-Yuan Su, Diane D Thomas, Elaina K Jones, Scott W Messenger, Jiayue Yang, Cheng Hu, Ilya Gukovsky, Zhenqiu Liu, Guy E Groblewski, Anna S Gukovskaya, Fred S Gorelick, Stephen J Pandol
Knowledge of the molecular mechanisms of acute pancreatitis is largely based on studies using rodents. To assess similar mechanisms in humans, we performed ex vivo pancreatitis studies in human acini isolated from cadaveric pancreata from organ donors. Since data on these human acinar preparations are sparse, we assessed their functional integrity, and cellular and organellar morphology using light, fluorescence and electron microscopy; and their proteome by liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
September 18, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28929519/left-superior-pulmonary-vein-connected-to-superior-vena-cava-vein-in-a-patient-with-situs-inversus-totalis-a-challenging-diagnosis
#2
Lionel Rozen, Nadia Debbas, Nash Damry, Aurelia David-Cojocariu, Didier de Cannière, Philippe Unger
We herein describe the previously unreported combination of partial anomalous venous connection to the superior vena cava combined with situs inversus totalis. Following peripheral contrast injection, bubbles appeared initially in the left atrium allowing the diagnosis of a supra-atrial connection to be made using transthoracic echocardiography, but this timing was not anymore reproduced during transesophageal echocardiography performed minutes later. Cardiac computed tomography allowed the final diagnosis to be made...
September 19, 2017: Echocardiography
https://www.readbyqxmd.com/read/28924735/the-g-protein-coupled-estrogen-receptor-gper-gpr30-may-serve-as-a-prognostic-marker-in-early-stage-cervical-cancer
#3
Klaus Friese, Bernd Kost, Aurelia Vattai, Frederik Marmé, Christina Kuhn, Sven Mahner, Christian Dannecker, Udo Jeschke, Sabine Heublein
BACKGROUND: Estrogen signalling is transmitted via various receptors and multiple intracellular signalling pathways. Estrogen receptor alpha (ERα)-mediated transcription of target genes has been demonstrated to be closely linked to human papilloma virus (HPV)-induced carcinogenesis in case of cervical cancer. So far, the role of non-genomic estrogen signals in cervical cancer, e.g. transmitted by the G protein-coupled estrogen receptor (GPER) remains to be rather elusive. Today's knowledge on the role of GPER in cervical cancer is sparse and-to the best of our knowledge-GPER has not been investigated in context with clinicopathological parameters or prognosis of cervical cancer...
September 18, 2017: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/28922247/review-of-safety-of-overlapping-surgery-at-a-high-volume-referral-center-by-hyder-ja-hanson-kt-storlie-cb-glasgow-a-madde-nr-brown-mj-kor-dj-cima-rr-habermann-eb-in-ann-surg-265-639-644-2017
#4
Aurelia T Perdanasari, Larry H Hollier
No abstract text is available yet for this article.
September 15, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28920117/hiv-haart-associated-oxidative-stress-is-detectable-by-metabonomics
#5
REVIEW
Aurelia A Williams, Lungile J Sitole, Debra Meyer
Chronic human immunodeficiency virus (HIV) infection, separately and in combination with highly active antiretroviral therapy (HAART) is closely associated with oxidative stress (OS). Most studies demonstrating redox imbalances in HIV-infected individuals have done so using conventional biochemical methodologies. The limited simultaneous detection of multiple OS markers within one sample is a major drawback of these methodologies and can be addressed through the use of metabonomics. HIV-metabonomic studies utilizing biofluids from HAART cohorts as the investigative source, are on the increase...
September 18, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28919082/diabetes-mellitus-and-obesity-as-risk-factors-for-pancreatic-cancer
#6
Guido Eibl, Zobeida Cruz-Monserrate, Murray Korc, Maxim S Petrov, Mark O Goodarzi, William E Fisher, Aida Habtezion, Aurelia Lugea, Stephen J Pandol, Phil A Hart, Dana K Andersen
Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest types of cancer. The worldwide estimates of its incidence and mortality in the general population are eight cases per 100,000 person-years and seven deaths per 100,000 person-years, and they are significantly higher in the United States than in the rest of the world. The incidence of this disease in the United States is more than 50,000 new cases in 2017. Indeed, total deaths due to PDAC are projected to increase dramatically to become the second leading cause of cancer-related deaths before 2030...
September 11, 2017: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/28919039/a-linear-diubiquitin-based-probe-for-efficient-and-selective-detection-of-the-deubiquitinating-enzyme-otulin
#7
Aurelia Weber, Paul R Elliott, Adan Pinto-Fernandez, Sarah Bonham, Benedikt M Kessler, David Komander, Farid El Oualid, Daniel Krappmann
The methionine 1 (M1)-specific deubiquitinase (DUB) OTULIN acts as a negative regulator of nuclear factor κB signaling and immune homeostasis. By replacing Gly76 in distal ubiquitin (Ub) by dehydroalanine we designed the diubiquitin (diUb) activity-based probe UbG76Dha-Ub (OTULIN activity-based probe [ABP]) that couples to the catalytic site of OTULIN and thereby captures OTULIN in its active conformation. The OTULIN ABP displays high selectivity for OTULIN and does not label other M1-cleaving DUBs, including CYLD...
August 28, 2017: Cell Chemical Biology
https://www.readbyqxmd.com/read/28900245/the-role-of-metronomic-capecitabine-for-treatment-of-recurrent-hepatocellular-carcinoma-after-liver-transplantation
#8
Matteo Ravaioli, Alessandro Cucchetti, Antonio Daniele Pinna, Vanessa De Pace, Flavia Neri, Maria Aurelia Barbera, Lorenzo Maroni, Giorgio Frega, Andrea Palloni, Stefania De Lorenzo, Maria Cristina Ripoli, Maria Abbondanza Pantaleo, Matteo Cescon, Massimo Del Gaudio, Giovanni Brandi
The management of recurrent hepatocellular carcinoma untreatable with surgical options is based on systemic therapy with sorafenib. Due to the high rates of adverse events connected to the therapy with sorafenib, metronomic capecitabine seems a promising strategy for these patients. We analyzed the data of 38 patients with hepatocellular carcinoma recurrent after liver transplantation performed at our center. We compared the outcome of 17 patients receiving metronomic capecitabine versus 20 patients experiencing best supportive care and versus the data of the literature about treatment with sorafenib...
September 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28899968/multi-spectral-optoacoustic-tomography-msot-of-human-breast-cancer
#9
Gael Diot, Stephan Metz, Aurelia Noske, Evangelos Liapis, Barbara Schroeder, Saak Victor Ovsepian, Reinhard Meier, Ernst J Rummeny, Vasilis Ntziachristos
PURPOSE: In a pilot study, we introduce fast handheld Multi-Spectral Optoacoustic Tomography (MSOT) of the breast at 28 wavelengths, aiming to identify high-resolution optoacoustic (photoacoustic) patterns of breast cancer and non-cancerous breast tissue. EXPERIMENTAL DESIGN: We imaged 10 female patients aged 48-81 years with malignant non-specific breast cancer or invasive lobular carcinoma. Three healthy volunteers aged 31-36 years were also imaged. Fast-MSOT was based on unique single-frame-per-pulse (SFPP) image acquisition employed to improve the accuracy of spectral differentiation over using a small number of wavelengths...
September 12, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28892446/funding-public-health-emergency-preparedness-in-the-united-states
#10
Rebecca Katz, Aurelia Attal-Juncqua, Julie E Fischer
The historical precedents that support state and local leadership in preparedness for and response to disasters are in many ways at odds with the technical demands of preparedness and response for incidents affecting public health. New and revised laws and regulations, executive orders, policies, strategies, and plans developed in response to biological threats since 2001 address the role of the federal government in the response to public health emergencies. However, financial mechanisms for disaster response-especially those that wait for gubernatorial request before federal assistance can be provided-do not align with the need to prevent the spread of infectious agents or efficiently reduce the impact on public health...
September 2017: American Journal of Public Health
https://www.readbyqxmd.com/read/28886117/incidence-of-pancreatic-cancer-is-dramatically-increased-by-a-high-fat-high-calorie-diet-in-krasg12d-mice
#11
Hui-Hua Chang, Aune Moro, Kazuki Takakura, Hsin-Yuan Su, Allen Mo, Masako Nakanishi, Richard T Waldron, Samuel W French, David W Dawson, O Joe Hines, Gang Li, Vay Liang W Go, James Sinnett-Smith, Stephen J Pandol, Aurelia Lugea, Anna S Gukovskaya, Michael O Duff, Daniel W Rosenberg, Enrique Rozengurt, Guido Eibl
Epidemiologic data has linked obesity to a higher risk of pancreatic cancer, but the underlying mechanisms are poorly understood. To allow for detailed mechanistic studies in a relevant model mimicking diet-induced obesity and pancreatic cancer, a high-fat, high-calorie diet (HFCD) was given to P48+/Cre;LSL-KRASG12D (KC) mice carrying a pancreas-specific oncogenic Kras mutation. The mice were randomly allocated to a HFCD or control diet (CD). Cohorts were sacrificed at 3, 6, and 9 months and tissues were harvested for further analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28885434/review-of-the-effect-of-technical-performance-on-patient-outcomes-in-surgery-a-systematic-review-by-fecso-ab-szasz-p-kerezov-g-grantcharov-tp-in-ann-surg-265-492-501-2017
#12
Kausar Ali, Aurelia T Perdanasari, Larry H Hollier
No abstract text is available yet for this article.
September 6, 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28884279/primary-hiv-infection-clinical-presentation-testing-and-treatment
#13
REVIEW
Aurélia Henn, Clara Flateau, Sébastien Gallien
PURPOSE OF REVIEW: The purpose of this review was to provide current data on clinical presentation, diagnosis, and treatment of primary HIV infection (PHI). RECENT FINDINGS: In 65 to 95% of cases, PHI causes acute retroviral syndrome presenting with unspecific flu-like symptoms. Symptomatic PHI was associated with a faster clinical and immunological progression of HIV infection. Point-of-care tests remain less sensitive than fourth-generation immunoassays (IA) in PHI, especially after tenofovir-based prophylaxis use...
September 7, 2017: Current Infectious Disease Reports
https://www.readbyqxmd.com/read/28874604/mitochondrial-redox-signaling-enables-repair-of-injured-skeletal-muscle-cells
#14
Adam Horn, Jack H Van der Meulen, Aurelia Defour, Marshall Hogarth, Sen Chandra Sreetama, Aaron Reed, Luana Scheffer, Navdeep S Chandel, Jyoti K Jaiswal
Strain and physical trauma to mechanically active cells, such as skeletal muscle myofibers, injures their plasma membranes, and mitochondrial function is required for their repair. We found that mitochondrial function was also needed for plasma membrane repair in myoblasts as well as nonmuscle cells, which depended on mitochondrial uptake of calcium through the mitochondrial calcium uniporter (MCU). Calcium uptake transiently increased the mitochondrial production of reactive oxygen species (ROS), which locally activated the guanosine triphosphatase (GTPase) RhoA, triggering F-actin accumulation at the site of injury and facilitating membrane repair...
September 5, 2017: Science Signaling
https://www.readbyqxmd.com/read/28872312/light-adaptation-in-phycobilisome-antennas-influence-on-the-rod-length-and-structural-arrangement
#15
Aurélia Chenu, Nir Keren, Yossi Paltiel, Reinat Nevo, Ziv Reich, Jianshu Cao
Phycobilisomes, the light-harvesting antennas of cyanobacteria, can adapt to a wide range of environments thanks to a composition and function response to stress conditions. We study how structural changes influence excitation transfer in these supercomplexes. Specifically, we show the influence of the rod length on the photon absorption and subsequent excitation transport to the core. Despite the fact that the efficiency of individual disks on the rod decreases with increasing rod length, we find an optimal length for which the average rod efficiency is maximal...
September 25, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28860563/pik3ca-exon9-mutations-associate-with-reduced-survival-and-are-highly-concordant-between-matching-primary-tumors-and-metastases-in-endometrial-cancer
#16
Siv Mjos, Henrica M J Werner, Even Birkeland, Frederik Holst, Anna Berg, Mari K Halle, Ingvild L Tangen, Kanthida Kusonmano, Karen K Mauland, Anne M Oyan, Karl-Henning Kalland, Aurélia E Lewis, Gordon B Mills, Camilla Krakstad, Jone Trovik, Helga B Salvesen, Erling A Hoivik
Mutations of the phosphoinositide-3-kinase (PI3K) catalytic subunit alpha gene (PIK3CA) are frequent in endometrial cancer. We sequenced exon9 and exon20 of PIK3CA in 280 primary endometrial cancers to assess the relationship with clinicopathologic variables, patient survival and associations with PIK3CA mRNA and phospho-AKT1 by gene expression and protein data, respectively. While PIK3CA mutations generally had no impact on survival, and were not associated with clinicopathological variables, patients with exon9 charge-changing mutations, providing a positive charge at the substituted amino acid residue, were associated with poor survival (p = 0...
August 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28843811/super-resolution-imaging-of-chromatin-in-pluripotency-differentiation-and-reprogramming
#17
REVIEW
Maria Aurelia Ricci, Maria Pia Cosma, Melike Lakadamyali
Chromatin fiber organization is essential for gene function in all cell types. Moreover it helps to determine cell fate in embryonic/adult stem cells and in somatic cells undergoing reprogramming to pluripotency. Until now the diffraction limit of light has limited the inspection of the chromatin fiber organization to a level sufficient to understand how it impacts gene function. The development of advanced microscopy methods, such as single molecule localization microscopy, has largely opened a new field of research providing us with the tools to visualize and quantitatively analyze chromatin fiber organization and thus gene activity at nanoscale resolution in single cells...
August 24, 2017: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/28807864/reducing-diagnostic-turnaround-times-of-exome-sequencing-for-families-requiring-timely-diagnoses
#18
Aurélie Bourchany, Christel Thauvin-Robinet, Daphné Lehalle, Ange-Line Bruel, Alice Masurel-Paulet, Nolwenn Jean, Sophie Nambot, Marjorie Willems, Laetitia Lambert, Salima El Chehadeh-Djebbar, Elise Schaefer, Aurélia Jaquette, Judith St-Onge, Charlotte Poe, Thibaud Jouan, Martin Chevarin, Patrick Callier, Anne-Laure Mosca-Boidron, Nicole Laurent, Mathilde Lefebvre, Frédéric Huet, Nada Houcinat, Sébastien Moutton, Christophe Philippe, Frédéric Tran-Mau-Them, Antonio Vitobello, Paul Kuentz, Yannis Duffourd, Jean-Baptiste Rivière, Julien Thevenon, Laurence Faivre
BACKGROUND AND OBJECTIVE: Whole-exome sequencing (WES) has now entered medical practice with powerful applications in the diagnosis of rare Mendelian disorders. Although the usefulness and cost-effectiveness of WES have been widely demonstrated, it is essential to reduce the diagnostic turnaround time to make WES a first-line procedure. Since 2011, the automation of laboratory procedures and advances in sequencing chemistry have made it possible to carry out diagnostic whole genome sequencing from the blood sample to molecular diagnosis of suspected genetic disorders within 50 h...
August 12, 2017: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/28803781/myc-regulates-chromatin-decompaction-and-nuclear-architecture-during-b-cell-activation
#19
Kyong-Rim Kieffer-Kwon, Keisuke Nimura, Suhas S P Rao, Jianliang Xu, Seolkyoung Jung, Aleksandra Pekowska, Marei Dose, Evan Stevens, Ewy Mathe, Peng Dong, Su-Chen Huang, Maria Aurelia Ricci, Laura Baranello, Ying Zheng, Francesco Tomassoni Ardori, Wolfgang Resch, Diana Stavreva, Steevenson Nelson, Michael McAndrew, Adriel Casellas, Elizabeth Finn, Charles Gregory, Brian Glenn St Hilaire, Steven M Johnson, Wendy Dubois, Maria Pia Cosma, Eric Batchelor, David Levens, Robert D Phair, Tom Misteli, Lino Tessarollo, Gordon Hager, Melike Lakadamyali, Zhe Liu, Monique Floer, Hari Shroff, Erez Lieberman Aiden, Rafael Casellas
50 years ago, Vincent Allfrey and colleagues discovered that lymphocyte activation triggers massive acetylation of chromatin. However, the molecular mechanisms driving epigenetic accessibility are still unknown. We here show that stimulated lymphocytes decondense chromatin by three differentially regulated steps. First, chromatin is repositioned away from the nuclear periphery in response to global acetylation. Second, histone nanodomain clusters decompact into mononucleosome fibers through a mechanism that requires Myc and continual energy input...
August 17, 2017: Molecular Cell
https://www.readbyqxmd.com/read/28796114/review-of-trauma-recidivism-predicts-long-term-mortality-by-strong-bl-greene-cr-smith-gs-in-ann-surg-265-847-853-2017
#20
Aurelia T Perdanasari, Tara L Braun, Larry H Hollier
No abstract text is available yet for this article.
September 2017: Journal of Craniofacial Surgery
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