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https://www.readbyqxmd.com/read/28086923/multiple-hiv-1-m%C3%A2-%C3%A2-hiv-1-o-dual-infections-and-new-hiv-1-mo-inter-group-recombinant-forms-detected-in-cameroon
#1
Fabienne De Oliveira, Thomas Mourez, Aurélia Vessiere, Paul-Alain Ngoupo, Elodie Alessandri-Gradt, François Simon, Dominique Rousset, Jean-Christophe Plantier
BACKGROUND: Due to the prevalence of HIV-1 group M and the endemicity of HIV-1 group O infections in Cameroon, patients may be infected with both viruses and/or with HIV-1/MO recombinant forms. Such atypical infections may be deleterious in terms of diagnosis and therapeutic management due to the high divergence of HIV-1/O. The aim of this study was to identify prospectively such atypical infections in Cameroon. RESULTS: Based on serological screening by env-V3 serotyping and a molecular strategy using group-specific (RT)-PCRs, we identified 10 Cameroonian patients harboring three different profiles of infection: (1) 4 HIV-1/M + O dual infections without evidence of recombinant; (2) 5 recombinants associated with one or both parental strains; and (3) 1 new recombinant form without parental strains...
January 13, 2017: Retrovirology
https://www.readbyqxmd.com/read/28079192/differential-cytotoxic-effects-of-graphene-and-graphene-oxide-on-skin-keratinocytes
#2
Marco Pelin, Laura Fusco, Verónica León, Cristina Martín, Alejandro Criado, Silvio Sosa, Ester Vázquez, Aurelia Tubaro, Maurizio Prato
Impressive properties make graphene-based materials (GBMs) promising tools for nanoelectronics and biomedicine. However, safety concerns need to be cleared before mass production of GBMs starts. As skin, together with lungs, displays the highest exposure to GBMs, it is of fundamental importance to understand what happens when GBMs get in contact with skin cells. The present study was carried out on HaCaT keratinocytes, an in vitro model of skin toxicity, on which the effects of four GBMs were evaluated: a few layer graphene, prepared by ball-milling treatment (FLG), and three samples of graphene oxide (GOs, a research-grade GO1, and two commercial GOs, GO2 and GO3)...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28079005/dendritic-cells-modulate-iron-homeostasis-and-inflammatory-abilities-following-quercetin-exposure
#3
Vanessa Galleggiante, Stefania De Santis, Elisabetta Cavalcanti, Aurelia Scarano, Maria De Benedictis, Grazia Serino, Maria Lucia Caruso, Mauro Mastronardi, Aldo Pinto, Pietro Campiglia, Dale Kunde, Angelo Santino, Marcello Chieppa
BACKGROUND: Fruit and vegetables are rich in plant polyphenols, whose consumption is encouraged in healthy dietary regimes due to their antioxidants and anti-inflammatory effects. These organic molecules exhibit numerous properties including phylochelation; the ability to create complex with metal ions. Among polyphenols, we focused our attention to quercetin that previously demonstrated its ability to reduce dendritic cells (DCs) inflammatory cytokine secretion and antigen presentation following LPS exposure...
January 12, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28073364/lack-of-mre11-rad50-nbs1-mrn-complex-detection-occurs-frequently-in-low-grade-epithelial-ovarian-cancer
#4
Simone Brandt, Eleftherios P Samartzis, Anne-Katrin Zimmermann, Daniel Fink, Holger Moch, Aurelia Noske, Konstantin J Dedes
BACKGROUND: BRCA1/2-deficient ovarian carcinomas are recognized as target for Poly (ADP-ribose) polymerase (PARP) inhibitors. BRCA1 and BRCA2 proteins are involved in homologous recombination repair of double-strand DNA breaks. The relevance of other homologous recombination repair proteins, e.g. MRE11, RAD50, NBS1 (MRN complex) in ovarian carcinomas is unclear. The objective of this study was to investigate the prevalence of lack of MRE11, RAD50, NBS1 protein detection in epithelial ovarian cancer (EOC)...
January 10, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28070243/value-of-serial-magnetic-resonance-imaging-in-the-assessment-of-brain-metastases-volume-control-during-stereotactic-radiosurgery
#5
Gianvincenzo Sparacia, Francesco Agnello, Aurelia Banco, Francesco Bencivinni, Andrea Anastasi, Giovanna Giordano, Adele Taibbi, Massimo Galia, Tommaso Vincenzo Bartolotta
AIM: To evaluate brain metastases volume control capabilities of stereotactic radiosurgery (SRS) through serial magnetic resonance (MR) imaging follow-up. METHODS: MR examinations of 54 brain metastases in 31 patients before and after SRS were reviewed. Patients were included in this study if they had a pre-treatment MR examination and serial follow-up MR examinations at 6 wk, 9 wk, 12 wk, and 12 mo after SRS. The metastasis volume change was categorized at each follow-up as increased (> 20% of the initial volume), stable (± 20% of the initial volume) or decreased (< 20% of the initial volume)...
December 28, 2016: World Journal of Radiology
https://www.readbyqxmd.com/read/28063128/improved-production-of-doubled-haploids-of-winter-and-spring-triticale-hybrids-via-combination-of-colchicine-treatments-on-anthers-and-regenerated-plants
#6
Aurelia Ślusarkiewicz-Jarzina, Hanna Pudelska, Jolanta Woźna, Tomasz Pniewski
Double haploids (DH), obtained during androgenesis in vitro or by genome diploidisation in regenerated haploids, are one type of basic materials used in triticale breeding programmes. The aim of this study was to improve DH production by a combination of colchicine treatment methods on a sample of five winter and five spring triticale hybrids. Colchicine was applied in vitro either in the C17 medium to induce embryo-like structures (ELS) or in the 190-2 medium for green plant (GP) development. Regenerants which remained haploid were immersed in a colchicine solution either when placed on the medium prior to transferring to soil or when growing in pots, followed by the application or absence of cooling...
January 6, 2017: Journal of Applied Genetics
https://www.readbyqxmd.com/read/28054352/impact-of-il13-genetic-polymorphism-arg130gln-on-total-serum-ige-levels-and-ifn-%C3%AE-gene-expression
#7
Bozena Smolkova, Jana Tulinska, Lubica Palkovicova Murinova, Verona Buocikova, Aurelia Liskova, Katarina Rausova, Miroslava Kuricova, Henrieta Patayova, Maria Sustrova, Eva Neubauerova Svorcova, Silvia Ilavska, Michaela Szabova, Tomas Nemessanyi, Eva Jahnova, Maria Dusinska, Peter Ciznar, Laurence Fuortes
This cross-sectional study was designed to investigate the extent of genetic susceptibility by targeting variants in IL-4/IL-13 signalling pathways leading to atopic disease in early childhood. We evaluated involvement of five single nucleotide polymorphisms IL4 C-590T, IL13 C-1055T, IL13 Arg130Gln, IL4RA Ile50Val and IL4RA Ser478Pro, in the control of serum total and antigen-specific IgE levels. Furthermore, we analyzed their association with changes in gene expression of five cytokines having key roles in inflammatory and anti-inflammatory immune response (IL-4, IL-13, IFN-γ, IL-8 and IL-10)...
January 5, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28040688/prevalence-of-pertussis-antibodies-in-maternal-blood-cord-serum-and-infants-from-mothers-with-and-those-without-tdap-booster-vaccination-during-pregnancy-in-argentina
#8
Aurelia A Fallo, Silvina E Neyro, Gabriela V Manonelles, Claudia Lara, Daniela Hozbor, Jonathan Zintgraff, Silvina Mazzeo, Héctor E Davison, Susana González, Estella Zapulla, Oscar Canle, Miguel Huespe, Marcelo Galas, Eduardo L López
BACKGROUND: Morbidity and mortality rates for pertussis in infants are high because disease often occurs before the onset of routine immunization or in those who do not complete a primary immunization series. Pertussis immunization is recommended during pregnancy to achieve antibody levels sufficient to protect young infants. To our knowledge, no previous reports of maternal pertussis immunization results in Latin America exist in the literature. METHODS: This study compared pertussis antibody levels in newborns from mothers who received or did not receive a tetanus-diphtheria-acellular pertussis vaccination (TdapV) during pregnancy...
December 30, 2016: Journal of the Pediatric Infectious Diseases Society
https://www.readbyqxmd.com/read/28039062/familial-and-syndromic-lupus-share-the-same-phenotype-as-other-early-onset-forms-of-lupus
#9
Olivia Weill, Stéphane Decramer, Christophe Malcus, Behrouz Kassai, Isabelle Rouvet, Tiphanie Ginhoux, Yanick Crow, Fredéric Rieux-Laucat, Pauline Soulas-Sprauel, Anne Pagnier, Isabelle Koné-Paut, Maryam Piram, Caroline Galeotti, Charlotte Samaille, Héloïse Reumaux, Aurélia Lanteri, Sandrine Morell Dubois, Hélène Lefebvre, Stéphane Burtey, François Maurier, Aurélia Carbasse, Irène Lemelle, Ulrich Meinzer, Véronique Despert, Hugues Flodrops, Nicole Fabien, Bruno Ranchin, Eric Hachulla, Brigitte Bader Meunier, Alexandre Belot
OBJECTIVE: Studies of early-onset systemic lupus erythematosus (SLE) have identified monogenic forms of the disease. The primary objective of this study was to compare the clinical and laboratory features of the first patients included in the GENIAL/LUMUGENE cohort to those reported in previous publications. The secondary objective was to determine whether subgroups with a distinctive pattern of clinical and biological features are seen in predominantly genetic forms of SLE. METHODS: GENIAL/LUMUGENE is a French nationwide study of the clinical, immunological, and genetic features of juvenile-onset SLE (clinicaltrials...
December 27, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28008151/tonsillar-cd56brightnkg2a-nk-cells-restrict-primary-epstein-barr-virus-infection-in-b-cells-via-ifn-%C3%AE
#10
Aurelia Jud, Monika Kotur, Christoph Berger, Claudine Gysin, David Nadal, Anna Lünemann
Natural killer (NK) cells constitute the first line of defense against viruses and cancers cells. Epstein-Barr virus (EBV) was the first human virus to be directly implicated in carcinogenesis, and EBV infection is associated with a broad spectrum of B cell lymphomas. How NK cells restrict EBV-associated oncogenesis is not understood. Here, we investigated the efficacies and mechanisms of distinct NK cell subsets from tonsils, the portal of entry of EBV, in limiting EBV infection in naïve, germinal center-associated and memory B cells...
December 20, 2016: Oncotarget
https://www.readbyqxmd.com/read/28003240/optimising-bone-health-in-the-young-male-athlete
#11
EDITORIAL
Adam S Tenforde, Aurelia Nattiv, Kathryn Ackerman, Michelle T Barrack, Michael Fredericson
No abstract text is available yet for this article.
December 21, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28002804/endometrial-cancer-cells-exhibit-high-expression-of-p110%C3%AE-and-its-selective-inhibition-induces-variable-responses-on-pi3k-signaling-cell-survival-and-proliferation
#12
Thomas Karlsson, Camilla Krakstad, Ingvild Løberg Tangen, Erling A Hoivik, Pamela M Pollock, Helga B Salvesen, Aurélia E Lewis
PTEN loss and constitutive activation of the class I phosphoinositide 3-kinase (PI3K) pathway are key drivers of endometrial tumorigenesis. In some cancer types, PTEN-deficient tumors are reliant on class I PI3K p110β (encoded by PIK3CB) activity but little is known about this contribution in endometrial tumorigenesis. In this study, we find that p110β is overexpressed in a panel of 7 endometrial cancer cell lines compared to non-transformed cells. Furthermore, in 234 clinically annotated patient samples, PIK3CB mRNA levels increase significantly in the early phase of tumorigenesis from precursors to low grade primary malignant lesions whereas PIK3CA levels are higher in non-endometrioid compared to endometrioid primary tumors...
December 16, 2016: Oncotarget
https://www.readbyqxmd.com/read/28002032/hyponatremia-unfavourable-prognostic-factor-in-hepatic-cirrhosis
#13
Aurelia Enescu, F Petrescu, P Mitruţ, V Pădureanu, Octavia Ileana Petrescu, Valeria Carmen Albu, Andreea Larisa Moraru, Anca Ştefania Enescu
Hyponatremia is defined by a level of Na in serum below or equal to 136 mEq/L while in hepatic cirrhosis it is classically considered as relevant only at a level of Na below 130 mEq/L. Hyponatremia frequently occurs in patients with end-stage hepatic disease. The frequency and severity are variable but it has been estimated that it occurs with a frequency of 57% in hospitalized patients with cirrhosis and in those on waiting lists for hepatic transplants. Signs and symptoms of hyponatremia are related to dysfunctions of the central nervous system, due to migration of the water from intravascular space to the brain cells, resulting in the occurrence of cerebral edema...
December 1, 2016: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/27995756/identification-of-mir-31-5p-mir-141-3p-mir-200c-3p-and-glt1-as-human-liver-aging-markers-sensitive-to-donor-recipient-age-mismatch-in-transplants
#14
Miriam Capri, Fabiola Olivieri, Catia Lanzarini, Daniel Remondini, Vincenzo Borelli, Raffaella Lazzarini, Laura Graciotti, Maria Cristina Albertini, Elena Bellavista, Aurelia Santoro, Fiammetta Biondi, Enrico Tagliafico, Elena Tenedini, Cristina Morsiani, Grazia Pizza, Francesco Vasuri, Antonietta D'Errico, Alessandro Dazzi, Sara Pellegrini, Alessandra Magenta, Marco D'Agostino, Maurizio C Capogrossi, Matteo Cescon, Maria Rita Rippo, Antonio Domenico Procopio, Claudio Franceschi, Gian Luca Grazi
To understand why livers from aged donors are successfully used for transplants, we looked for markers of liver aging in 71 biopsies from donors aged 12-92 years before transplants and in 11 biopsies after transplants with high donor-recipient age-mismatch. We also assessed liver function in 36 age-mismatched recipients. The major findings were the following: (i) miR-31-5p, miR-141-3p, and miR-200c-3p increased with age, as assessed by microRNAs (miRs) and mRNA transcript profiling in 12 biopsies and results were validated by RT-qPCR in a total of 58 biopsies; (ii) telomere length measured by qPCR in 45 samples showed a significant age-dependent shortage; (iii) a bioinformatic approach combining transcriptome and miRs data identified putative miRs targets, the most informative being GLT1, a glutamate transporter expressed in hepatocytes...
December 20, 2016: Aging Cell
https://www.readbyqxmd.com/read/27987966/guar-gum-as-biosourced-building-block-to-generate-highly-conductive-and-elastic-ionogels-with-poly-ionic-liquid-and-ionic-liquid
#15
Biao Zhang, Guillaume Sudre, Guilhem Quintard, Anatoli Serghei, Laurent David, Julien Bernard, Etienne Fleury, Aurélia Charlot
In this study, we report on the simple and straightforward preparation of ionogels arising from the addition of guar gum (a plant-based polysaccharide) in a solution of precisely-defined poly(ionic liquid) chains (PIL) in imidazolium-based ionic liquid (IL). The development of intermolecular polar interactions (mainly hydrogen bonds) and topologic chain entanglements induces the formation of physical biohybrid ionogels, whose elastic properties can be easily tuned by varying the composition (up to 30000Pa)...
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27981304/the-impact-of-hypoxaemia-on-the-outcome-in-liver-cirrhosis
#16
Andrei Mihai Voiosu, Theodor Alexandru Voiosu, Bianca Smarandache, Aurelia Rădoi, Radu Bogdan Mateescu, Cristian Răsvan Băicuş, Mihail Radu Voiosu, Mihai Mircea Diculescu
BACKGROUND AND AIMS: Prognostic factors for poor evolution are critical in the setting of limited access to liver transplantation for patients with cirrhosis. We aimed to investigate the impact of hypoxaemia on the outcome in cirrhosis and the evolution of arterial oxygen tension during long-term follow-up in these patients. METHODS: Consecutive cirrhotic patients were prospectively enroled and followed-up in our tertiary referral center. Clinical features, biological tests, arterial blood gases, NT-proBNP levels, pulse oximetry measurements, 12-lead ECG, and transthoracic contrast echocardiography were documented on enrolment...
December 2016: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/27979699/childhood-trauma-and-emotional-processing-circuits-in-schizophrenia-a-functional-connectivity-study
#17
Aïda Cancel, Magali Comte, Claire Boutet, Fabien C Schneider, Pierre-François Rousseau, Sarah Boukezzi, Aurélia Gay, Torrance Sigaud, Catherine Massoubre, Fabrice Berna, Xavier Y Zendjidjian, Jean-Michel Azorin, Olivier Blin, Eric Fakra
Childhood trauma strongly impacts emotional responses in schizophrenia. We have explored an association between early trauma and the amygdala functional connectivity using generalized psychophysiological interaction during an emotional task. Twenty-one schizophrenia patients and twenty-five controls were included. In schizophrenia patients, higher levels of sexual abuse and physical neglect during childhood were associated with decreased connectivity between the amygdala and the posterior cingulate/precuneus region...
December 13, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27977625/exosome-mediated-intercellular-communication-between-stellate-cells-and-cancer-cells-in-pancreatic-ductal-adenocarcinoma
#18
Aurelia Lugea, Richard T Waldron
No abstract text is available yet for this article.
January 2017: Pancreas
https://www.readbyqxmd.com/read/27966282/enzyme-from-an-uncultivated-sponge-bacterium-catalyzes-s-methylation-in-a-ribosomal-peptide
#19
Maximilian Helf, Aurelia Jud, Jörn Piel
Amino acid modifications are essential for the structural diversity and bioactivity of ribosomally synthesized and posttranslationally modified peptide natural products (RiPPs). A particularly large and virtually untapped pool of unusual RiPPs and associated modifying enzymes is provided by uncultivated bacteria. An example is the chemically rich sponge symbiont 'Candidatus Entotheonella factor' that produces the hypermodified polytheonamides of the poorly studied proteusin RiPP family. In addition to the polytheonamide genes, 'E...
December 14, 2016: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/27965258/a-new-autoinflammatory-and-autoimmune-syndrome-associated-with-nlrp1-mutations-naiad-nlrp1-associated-autoinflammation-with-arthritis-and-dyskeratosis
#20
Sylvie Grandemange, Elodie Sanchez, Pascale Louis-Plence, Frédéric Tran Mau-Them, Didier Bessis, Christine Coubes, Eric Frouin, Marieke Seyger, Manon Girard, Jacques Puechberty, Valérie Costes, Michel Rodière, Aurélia Carbasse, Eric Jeziorski, Pierre Portales, Guillaume Sarrabay, Michel Mondain, Christian Jorgensen, Florence Apparailly, Esther Hoppenreijs, Isabelle Touitou, David Geneviève
OBJECTIVES: Inflammasomes are multiprotein complexes that sense pathogens and trigger biological mechanisms to control infection. Nucleotide-binding oligomerisation domain-like receptor (NLR) containing a PYRIN domain 1 (NLRP1), NLRP3 and NLRC4 plays a key role in this innate immune system by directly assembling in inflammasomes and regulating inflammation. Mutations in NLRP3 and NLRC4 are linked to hereditary autoinflammatory diseases, whereas polymorphisms in NLRP1 are associated with autoimmune disorders such as vitiligo and rheumatoid arthritis...
December 13, 2016: Annals of the Rheumatic Diseases
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