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Laura Ferlauto, Marta Jole Ildelfonsa Airaghi Leccardi, Naïg Aurelia Ludmilla Chenais, Samuel Charles Antoine Gilliéron, Paola Vagni, Michele Bevilacqua, Thomas J Wolfensberger, Kevin Sivula, Diego Ghezzi
Retinal prostheses have been developed to fight blindness in people affected by outer retinal layer dystrophies. To date, few hundred patients have received a retinal implant. Inspired by intraocular lenses, we have designed a foldable and photovoltaic wide-field epiretinal prosthesis (named POLYRETINA) capable of stimulating wireless retinal ganglion cells. Here we show that within a visual angle of 46.3 degrees, POLYRETINA embeds 2215 stimulating pixels, of which 967 are in the central area of 5 mm, it is foldable to allow implantation through a small scleral incision, and it has a hemispherical shape to match the curvature of the eye...
March 8, 2018: Nature Communications
Cheng Xu, Yunlong Zi, Aurelia Chi Wang, Haiyang Zou, Yejing Dai, Xu He, Peihong Wang, Yi-Cheng Wang, Peizhong Feng, Dawei Li, Zhong Lin Wang
A long debate on the charge identity and the associated mechanisms occurring in contact-electrification (CE) (or triboelectrification) has persisted for many decades, while a conclusive model has not yet been reached for explaining this phenomenon known for more than 2600 years! Here, a new method is reported to quantitatively investigate real-time charge transfer in CE via triboelectric nanogenerator as a function of temperature, which reveals that electron transfer is the dominant process for CE between two inorganic solids...
March 6, 2018: Advanced Materials
Florian Barthélémy, Aurélia Defour, Nicolas Lévy, Martin Krahn, Marc Bartoli
Skeletal muscle undergoes many micro-membrane lesions at physiological state. Based on their sizes and magnitude these lesions are repaired via different complexes on a specific spatio-temporal manner. One of the major repair complex is a dysferlin-dependent mechanism. Accordingly, mutations in the DYSF gene encoding dysferlin results in the development of several muscle pathologies called dysferlinopathies, where abnormalities of the membrane repair process have been characterized in patients and animal models...
2018: Journal of Neuromuscular Diseases
Stavroula Stavrou, Michael Gratz, Eileen Tremmel, Christina Kuhn, Simone Hofmann, Helene Heidegger, Mina Peryanova, Kerstin Hermelink, Stefan Hutter, Bettina Toth, Doris Mayr, Sven Mahner, Udo Jeschke, Aurelia Vattai
OBJECTIVES: Thyroid hormones play an important role in the maintenance of pregnancy. Their derivates, endogenous amines, act via binding to the trace amine-associated receptor (TAAR1). The aim of our study was to analyse the regulation of TAAR1, serine/threonine kinase (pGSK3β) and ornithine decarboxylase (ODC) in placentas of healthy pregnancies, spontaneous (SM) and recurrent miscarriages (RM) and to investigate the influence of thyroid hormone derivates on TAAR1 expression in trophoblast model cells in vitro ...
February 2018: Endocrine Connections
Graeme Ball, Feng Xie, Jean-Eric Tarride
BACKGROUND: Ovarian cancer is a leading cause of cancer-related mortality. Although the disease is relatively rare, it carries a disproportionately large morbidity burden. OBJECTIVE: We conducted a cost-utility analysis from a Canadian public payer perspective to determine the cost effectiveness of bevacizumab, a newly available treatment option for recurrent ovarian cancer. METHODS: Using a 7-year time horizon, a three health-state cohort-based partitioned survival model was developed to assess the cost utility of bevacizumab plus chemotherapy (BEV) versus chemotherapy alone...
March 2018: PharmacoEconomics Open
Caterina Fusco, Michele Casiello, Lucia Catucci, Roberto Comparelli, Pietro Cotugno, Aurelia Falcicchio, Francesco Fracassi, Valerio Margiotta, Anna Moliterni, Francesca Petrone, Lucia D'Accolti, Angelo Nacci
Anatase (TiO₂) and multiwalled carbon nanotubes bearing polyethylenimine (PEI) anchored on their surface were hybridized in different proportions according to a sol-gel method. The resulting nanocomposites (TiO₂@PEI-MWCNTs), characterized by BET, XRD, XPS, SEM, and UV techniques, were found efficient catalysts for CO₂ photoreduction into formic and acetic acids in water suspension and under visible light irradiation. PEI-grafted nanotubes co-catalysts are believed to act as CO₂ activators by forming a carbamate intermediate allowing to accomplish the first example in the literature of polyamines/nanotubes/TiO₂ mediated CO₂ photoreduction to carboxylic acids...
February 20, 2018: Materials
Jianan Deng, Xiao Kuang, Ruiyuan Liu, Wenbo Ding, Aurelia C Wang, Ying-Chih Lai, Kai Dong, Zhen Wen, Yaxian Wang, Lili Wang, H Jerry Qi, Tong Zhang, Zhong Lin Wang
Functional polymers possess outstanding uniqueness in fabricating intelligent devices such as sensors and actuators, but they are rarely used for converting mechanical energy into electric power. Here, a vitrimer based triboelectric nanogenerator (VTENG) is developed by embedding a layer of silver nanowire percolation network in a dynamic disulfide bond-based vitrimer elastomer. In virtue of covalent dynamic disulfide bonds in the elastomer matrix, a thermal stimulus enables in situ healing if broken, on demand reconfiguration of shape, and assembly of more sophisticated structures of VTENG devices...
February 19, 2018: Advanced Materials
Andrei Mihai Voiosu, Paul Bălănescu, Ioana Daha, Bianca Smarandache, Aurelia Rădoi, Radu Bogdan Mateescu, Cristian Răsvan Băicuş, Theodor Alexandru Voiosu
BACKGROUND: We aimed to determine the relationship between endocan and cirrhotic cardiomyopathy. MATERIALS AND METHODS: Patients with liver cirrhosis and no heart disease were included in a prospective observational study with liver disease decompensation and death as primary outcomes. RESULTS: 83 cirrhotic patients were included and 32 had cirrhotic cardiomyopathy. Endocan levels were significantly lower in patients with cirrhotic cardiomyopathy (5...
February 16, 2018: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
Aurelia C Kucera, Britt J Heidinger
Collection of semen may be useful for a wide range of applications including studies involving sperm quality, sperm telomere dynamics, and epigenetics. Birds are widely used subjects in biological research and are ideal for studies involving repeated sperm samples. However, few resources are currently available for those wishing to learn how to collect and extract DNA from avian sperm. Here we describe cloacal massage, a gentle, non-invasive manual technique for collecting avian sperm. Although this technique is established in the literature, it can be difficult to learn from the available descriptions...
February 5, 2018: Journal of Visualized Experiments: JoVE
Rutherford, Emer Forde, Jacqueline Priego-Hernandez, Aurelia Butcher, Clare Wedderburn
The capacity and the commitment to reflect are integral to the practice of medicine and are core components of most general practitioners (GP) training programmes. Teaching through the humanities is a growing area within medical education, but one which is often considered a voluntary 'add-on' for the interested doctor. This article describes an evaluation of a highly innovative pedagogical project which used photography as a means to enhance GP trainees' reflective capacity, self-awareness and professional development...
February 8, 2018: Medical Humanities
Patrick Bonin, Alain Méot, Aurélia Bugaiska
Words that correspond to a potential sensory experience-concrete words-have long been found to possess a processing advantage over abstract words in various lexical tasks. We collected norms of concreteness for a set of 1,659 French words, together with other psycholinguistic norms that were not available for these words-context availability, emotional valence, and arousal-but which are important if we are to achieve a better understanding of the meaning of concreteness effects. We then investigated the relationships of concreteness with these newly collected variables, together with other psycholinguistic variables that were already available for this set of words (e...
February 12, 2018: Behavior Research Methods
Aurélia Bertholet-Thomas, Debora Claramunt-Taberner, Ségolène Gaillard, Georges Deschênes, Elisabeth Sornay-Rendu, Pawel Szulc, Martine Cohen-Solal, Solenne Pelletier, Marie-Christine Carlier, Pierre Cochat, Justine Bacchetta
BACKGROUND: Bone impairment appears to be a novel complication of nephropathic cystinosis despite cysteamine therapy. Its exact underlying pathophysiology is nevertheless unclear. The objective of this study was to evaluate bone status among patients included in the French Crystobs study. METHODS: In addition to clinical data, bone status was evaluated using biomarkers (ALP, PTH, 25-D, 1-25D, FGF23), DXA (spine and total body), and high-resolution peripheral quantitative computed tomography (HR-pQCT) at the tibia and radius...
February 12, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
Saber Khelaifia, Aurelia Caputo, Claudia Andrieu, Frederique Cadoret, Nicholas Armstrong, Caroline Michelle, Jean-Christophe Lagier, Felix Djossou, Pierre-Edouard Fournier, Didier Raoult
By applying the culturomics concept and using culture conditions containing a high salt concentration, we herein isolated the first known halophilic archaeon colonizing the human gut. Here we described its phenotypic and biochemical characterization as well as its genome annotation. Strain Arc-HrT (= CSUR P0974 = CECT 9307) was mesophile and grew optimally at 37 °C and pH 7. Strain Arc-HrT was also extremely halophilic with an optimal growth observed at 15% NaCl. It showed gram-negative cocci, was strictly aerobic, non-motile and non-spore-forming, and exhibited catalase and oxidase activities...
February 12, 2018: Extremophiles: Life Under Extreme Conditions
Aurelia H M de Vries Schultink, Annelies H Boekhout, Jourik A Gietema, Artur M Burylo, Thomas P C Dorlo, J G Coen van Hasselt, Jan H M Schellens, Alwin D R Huitema
Trastuzumab is associated with cardiotoxicity, manifesting as a decrease of the left-ventricular ejection fraction (LVEF). Administration of anthracyclines prior to trastuzumab increases risk of cardiotoxicity. High-sensitive troponin T and N-terminal-pro-brain natriuretic peptide (NT-proBNP) are molecular markers that may allow earlier detection of drug-induced cardiotoxicity. In this analysis we aimed to quantify the kinetics and exposure-response relationships of LVEF, troponin T and NT-proBNP measurements, in patients receiving anthracycline and trastuzumab...
February 10, 2018: Journal of Pharmacokinetics and Pharmacodynamics
Louise de Swart, Alex Smith, Detlef Haase, Pierre Fenaux, Argiris Symeonidis, Jaroslav Cermak, Guillermo Sanz, Reinhard Stauder, Moshe Mittelman, Eva Hellström-Lindberg, Luca Malcovati, Saskia Langemeijer, Mette Skov-Holm, Krzysztof Mądry, Ulrich Germing, Antonio Medina Almeida, Aurelia Tatic, Aleksandar Savic, Njetočka Gredelj Šimec, Corine van Marrewijk, Agnes Guerci-Bresler, Laurence Sanhes, Elisa Luño, Dominic Culligan, Odile Beyne-Rauzy, Sonja Burgstaller, Nicole Blijlevens, David Bowen, Theo de Witte
Conventional karyotype is one of the most relevant prognostic factors in MDS. However, about 50% of patients with MDS have a normal karyotype. Usually, 20-25 normal metaphases (nMP) are considered to be optimal to exclude small abnormal clones which might be associated with poor prognosis. This study evaluated the impact of examining a suboptimal number of metaphases in patients recruited to the EUMDS Registry with low and intermediate-1 risk according to IPSS. Only 179/1049 (17%) of patients with a normal karyotype had a suboptimal number of nMP, defined as less than 20 metaphases analyzed...
January 31, 2018: Leukemia Research
Margarida Hermida, Bárbara Cavaleiro, Lídia Gouveia, Aurélia Saraiva
Skipjack tuna, Katsuwonus pelamis, is a tropical species of economic importance for fisheries around the world. It occurs seasonally in subtropical waters around Madeira archipelago, in the warmer months. In this study, a parasitological analysis was carried out on a sample of 30 skipjack caught near Madeira Island. A total of 24 parasite taxa were found in this sample. The skipjack parasite community detected was characterized by a wide diversity of parasites, with a predominance of adult didymozoid trematodes, and high prevalences of Tentacularia coryphaenae cestode larvae and Anisakis sp...
February 3, 2018: Parasitology Research
Aurelia Bihari, Gediminas Cepinskas, David Sanders, Abdel-Rahman Lawendy
OBJECTIVES: Acute limb compartment syndrome, a complication of musculoskeletal trauma, results in muscle necrosis and cell death. Carbon monoxide, liberated from the carbon monoxide-releasing molecule-3, has been shown protective in a rat model of compartment syndrome. The purpose of this study was to test the effect of carbon monoxide-releasing molecule-3 in a preclinical large animal model of compartment syndrome, with the ultimate goal of developing a pharmacologic adjunct treatment for compartment syndrome...
January 30, 2018: Critical Care Medicine
Miriam Flores Moreno, Karina Saray Pueblas Bedoy, Aurelia Ojeda Sánchez, Jessie Zurita-Cruz
BACKGROUND: In pediatrics, complications of the peripherally inserted central venous catheters (PICC) are reported in 30% to 40% of cases, with the most frequent risk factors being the age of the patient and the location of PICC. The aim of this study was to describe the characteristics of PICCs and to identify factors related to their withdrawal due to complications. METHODS: Prospective cohort study. Patients from 2 months to 18 years of age were included and followed-up until PICC was withdrawn...
July 2017: Boletín Médico del Hospital Infantil de México
Claudia Mehedințu, Lăcrămioara Aurelia Brîndușe, Elvira Brătilă, Michele Monroc, Ebticem Lemercier, Olivier Suaud, Cecile Collet-Savoye, Horace Roman
STUDY OBJECTIVE: To evaluate whether combining Computed Tomography-based virtual Colonoscopy (CTC) with Magnetic Resonance Imaging (MRI) improves preoperative assessment of colorectal endometriosis. DESIGN: Retrospective study using prospectively recorded data (Canadian Task Force classification II-2). SETTING: University tertiary referral center. PATIENTS: Seventy-one women treated for colorectal endometriosis managed between June 2015 and May 2016...
January 25, 2018: Journal of Minimally Invasive Gynecology
Hélène Guiraud, Nathalie Bedoin, Sonia Krifi-Papoz, Vania Herbillon, Aurélia Caillot-Bascoul, Sibylle Gonzalez-Monge, Véronique Boulenger
BACKGROUND: Perception of speech rhythm requires the auditory system to track temporal envelope fluctuations, which carry syllabic and stress information. Reduced sensitivity to rhythmic acoustic cues has been evidenced in children with Specific Language Impairment (SLI), impeding syllabic parsing and speech decoding. Our study investigated whether these children experience specific difficulties processing fast rate speech as compared with typically developing (TD) children. METHOD: Sixteen French children with SLI (8-13 years old) with mainly expressive phonological disorders and with preserved comprehension and 16 age-matched TD children performed a judgment task on sentences produced 1) at normal rate, 2) at fast rate or 3) time-compressed...
2018: PloS One
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