keyword
https://read.qxmd.com/read/38451468/association-and-disparities-of-food-insecurity-and-exposure-to-violence-analysis-of-the-national-survey-of-children-s-health
#21
JOURNAL ARTICLE
Molly Bloom, Cassie McCoy, Amy D Hendrix-Dicken, Covenant Elenwo, Michael A Baxter, Sara Coffey, Micah Hartwell
CONTEXT: Lack of access to food is a significant concern for child well-being, and it creates many health disparities and adverse social outcomes. Food insecurity and its many associated risk factors increase parental stress, which are strongly correlated with an increased risk of child abuse and maltreatment. Research now identifies being witness to domestic abuse as a form of child maltreatment, and exposure to violence in the community has been shown to result in similar long-term impacts...
March 8, 2024: Journal of osteopathic medicine
https://read.qxmd.com/read/38447251/prognostic-factors-in-high-grade-pediatric-osteosarcoma-among-children-and-young-adults-greek-nationwide-registry-for-childhood-hematological-malignancies-and-solid-tumors-narechem-st-data-along-with-a-systematic-review-and-meta-analysis
#22
JOURNAL ARTICLE
Evgenia Papakonstantinou, Kleoniki I Athanasiadou, Georgios Markozannes, Vassiliki Tzotzola, Evdoxia Bouka, Margarita Baka, Maria Moschovi, Sophia Polychronopoulou, Emmanuel Hatzipantelis, Vasiliki Galani, Kalliopi Stefanaki, Katerina Strantzia, Maria Vousvouki, Panagiota Kourou, Evgenia Magkou, Maria Nikita, Christos Zambakides, John Michelarakis, Aikaterini Alexopoulou, Maro Gavra, Astero Malama, Evangelia E Ntzani, Eleni Th Petridou
The 5-year overall survival of children and adolescents with osteosarcoma has been in plateau during the last 30 years. The present systematic review (1976-2023) and meta-analysis aimed to explore factors implicated in the prognosis of children and young adults with high-grade osteosarcoma. Original studies including patients ≤30 years and the Nationwide Registry for Childhood Hematological Malignancies and Solid Tumors (NARECHEM-ST) data (2010-2021) referred to children ≤14 years were analysed...
March 5, 2024: Cancer Epidemiology
https://read.qxmd.com/read/38446898/childhood-adverse-life-events-and-skeletal-muscle-mitochondrial-function
#23
JOURNAL ARTICLE
Kate A Duchowny, David J Marcinek, Theresa Mau, L Grisell Diaz-Ramierz, Li-Yung Lui, Frederico G S Toledo, Peggy M Cawthon, Russell T Hepple, Philip A Kramer, Anne B Newman, Stephen B Kritchevsky, Steven R Cummings, Paul M Coen, Anthony J A Molina
Social stress experienced in childhood is associated with adverse health later in life. Mitochondrial function has been implicated as a mechanism for how stressful life events "get under the skin" to influence physical well-being. Using data from the Study of Muscle, Mobility, and Aging ( n = 879, 59% women), linear models examined whether adverse childhood events (i.e., physical abuse) were associated with two measures of skeletal muscle mitochondrial energetics in older adults: (i) maximal adenosine triphosphate production (ATPmax ) and (ii) maximal state 3 respiration (Max OXPHOS)...
March 8, 2024: Science Advances
https://read.qxmd.com/read/38442479/adverse-childhood-experiences-and-recent-negative-events-are-associated-with-activated-immune-and-growth-factor-pathways-the-phenome-of-first-episode-major-depression-and-suicidal-behaviors
#24
JOURNAL ARTICLE
Abbas F Almulla, Ali Abbas Abo Algon, Michael Maes
This research assessed the effects of adverse childhood experiences (ACEs) and negative life events (NLEs) on forty-eight cytokines/chemokines/growth factors, in 71 FE-MDMD patients and forty heathy controls. ACEs are highly significantly associated with the classical M1 macrophage, T helper (Th)-1, Th-1 polarization, IRS, and neurotoxicity immune profiles, and not with the alternative M2, and Th-2 immune profiles. There are highly significant correlations between ACEs and NLEs and different cytokines/chemokines/growth factors, especially with interleukin (IL)-16, CCL27, stem cell growth factor, and platelet-derived growth factor...
February 29, 2024: Psychiatry Research
https://read.qxmd.com/read/38441939/telehealth-movement-to-music-with-arm-based-sprint-intensity-interval-training-to-improve-cardiometabolic-health-and-cardiorespiratory-fitness-in-children-with-cerebral-palsy-protocol-for-a-pilot-randomized-controlled-trial
#25
JOURNAL ARTICLE
Byron Lai, Robert A Oster, Drew Davis, Larsen Bright, Gordon Fisher, Jereme Wilroy, Yumi Kim, Raven Young, Ashley Wright, Tanvee Sinha, James H Rimmer
BACKGROUND: Children with mobility disabilities, including those with cerebral palsy, have limited options and limited time to exercise to manage their cardiometabolic health and cardiorespiratory fitness. Regular cardiovascular exercise during childhood is a critical health behavior for preventing health decline in adulthood. Thus, there is an urgent need for accessible, age-appropriate, convenient exercise modalities in this group. Sprint-intensity interval training (SIT), combined with telehealth procedures, may be ideal for children with disabilities...
March 5, 2024: JMIR Research Protocols
https://read.qxmd.com/read/38441157/once-in-neet-always-in-neet-childhood-and-adolescent-risk-factors-for-different-neet-patterns
#26
JOURNAL ARTICLE
Karin Veldman, Sander K R van Zon, Ute Bültmann
BACKGROUND: Young adults in Neither in Employment, Education nor Training (NEET) are at risk of adverse labour market outcomes. Earlier studies often measured NEET status at one time point or compared persistent NEETs with non-NEETs, neglecting other patterns of NEET status. Evidence on early life factors associated with NEET patterns is lacking. This study aims to (i) identify patterns of NEET status over time and (ii) examine whether factors in childhood and adolescence are associated with these patterns...
March 4, 2024: European Journal of Public Health
https://read.qxmd.com/read/38430794/measuring-interpersonal-trauma-development-and-validation-of-the-german-version-of-the-victimization-experience-schedule-ves
#27
JOURNAL ARTICLE
Armin Drusko, Malika Renz, Hannah Schmidt, Michelle Rosin, Joe Simon, Eva Beiner, Monica Charalambides, Andreas Meyer-Lindenberg, Rolf-Detlef Treede, Heike Tost, Jonas Tesarz
OBJECTIVE: Interpersonal victimization experiences (VEs) significantly affect mental and physical health, particularly in disorders associated with life-time adversities, like fibromyalgia syndrome (FMS) and major depressive disorder (MDD). However, assessing VEs comprehensively remains challenging due to limited tools that encompass sub-traumatic events, such as bullying or discrimination, and contextual dimensions. We aimed to address this gap by validating the Victimization Experience Schedule (VES) in German, examining its reliability, and assessing VEs in clinical populations with FMS and MDD...
February 23, 2024: Journal of Psychosomatic Research
https://read.qxmd.com/read/38421487/predictive-factors-for-l-asparaginase-hypersensitivity-in-pediatric-acute-lymphoblastic-leukemia
#28
JOURNAL ARTICLE
Chane Choed-Amphai, Jiraporn Khorana, Lalita Sathitsamitphong, Rungrote Natesirinilkul, Pimlak Charoenkwan
BACKGROUND: L-Asparaginase is a crucial component of acute lymphoblastic leukemia (ALL) treatment. However, hypersensitivity is a common adverse event. This study aimed to identify risk factors for L-asparaginase hypersensitivity in childhood ALL. METHODS: Children treated for ALL at Chiang Mai University Hospital, Thailand, between 2005 and 2020 were included. Demographic data, clinical characteristics, and factors related to L-asparaginase were retrospectively reviewed...
February 29, 2024: International Journal of Hematology
https://read.qxmd.com/read/38418208/factors-that-impact-second-attempt-success-for-neonatal-intubation-following-first-attempt-failure-a-report-from-the-national-emergency-airway-registry-for-neonates
#29
JOURNAL ARTICLE
Mitchell David Johnson, David Gerald Tingay, Elizabeth J Perkins, Arun Sett, Bianca Devsam, Ellen Douglas, Julia K Charlton, Paul Wildenhain, Jennifer Rumpel, Michael Wagner, Vinay Nadkarni, Lindsay Johnston, Heidi M Herrick, Tyler Hartman, Kristen Glass, Philipp Jung, Stephen D DeMeo, Rebecca Shay, Jae H Kim, Jennifer Unrau, Ahmed Moussa, Akira Nishisaki, Elizabeth E Foglia
OBJECTIVE: To determine the factors associated with second attempt success and the risk of adverse events following a failed first attempt at neonatal tracheal intubation. DESIGN: Retrospective analysis of prospectively collected data on intubations performed in the neonatal intensive care unit (NICU) and delivery room from the National Emergency Airway Registry for Neonates (NEAR4NEOS). SETTING: Eighteen academic NICUs in NEAR4NEOS. PATIENTS: Neonates requiring two or more attempts at intubation between October 2014 and December 2021...
February 28, 2024: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://read.qxmd.com/read/38407859/varying-doses-of-epicutaneous-immunotherapy-with-viaskin-milk-vs-placebo-in-children-with-cow-s-milk-allergy-a-randomized-clinical-trial
#30
JOURNAL ARTICLE
Daniel Petroni, Philippe Bégin, J Andrew Bird, Terri Brown-Whitehorn, Hey J Chong, David M Fleischer, Rémi Gagnon, Stacie M Jones, Stephanie Leonard, Melanie M Makhija, Roxanne C Oriel, Wayne G Shreffler, Sayantani B Sindher, Gordon L Sussman, William H Yang, Katharine J Bee, Timothée Bois, Dianne E Campbell, Todd D Green, Karine Rutault, Hugh A Sampson, Robert A Wood
IMPORTANCE: No approved treatment exists for allergen-specific immunoglobulin E (IgE)-mediated cow's milk allergy (CMA), a common childhood food allergy. OBJECTIVE: To assess dose, efficacy, and safety of epicutaneous immunotherapy with Viaskin milk in children with IgE-mediated CMA. DESIGN, SETTING, AND PARTICIPANTS: A phase 1/2, 2-part, randomized, double-blind, placebo-controlled dose-ranging clinical trial in children aged 2 to 17 years with IgE-mediated CMA was conducted between November 2014 through December 2017...
February 26, 2024: JAMA Pediatrics
https://read.qxmd.com/read/38407101/eating-behaviors-as-pathways-from-early-childhood-adversity-to-adolescent-cardiometabolic-risk
#31
JOURNAL ARTICLE
Jenalee R Doom, LillyBelle K Deer, Trudy Mickel, Andrea Infante, Kenia M Rivera
OBJECTIVE: To identify specific eating behavior pathways that mediate associations between financial difficulties, negative life events, and maternal depressive symptoms from 0 to 5 years and cardiometabolic risk in adolescence. METHOD: Hypotheses were tested with data from birth to age 15 years using the Avon Longitudinal Study of Parents and Children, a birth cohort in the United Kingdom ( n = 3,887 for current analyses). Mothers reported on financial difficulties, negative life events, and maternal depressive symptoms at multiple points from 0 to 5 years and reported on worry about child overeating at 8 years...
February 26, 2024: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://read.qxmd.com/read/38392241/access-to-dental-care-for-children-and-young-people-in-care-and-care-leavers-a-global-scoping-review
#32
REVIEW
Jo Erwin, Jane Horrell, Hannah Wheat, Nick Axford, Lorna Burns, Joelle Booth, Robert Witton, Jill Shawe, Janine Doughty, Sarah Kaddour, Skye Boswell, Urshla Devalia, Abigail Nelder, Martha Paisi
AIMS: This scoping review aimed to explore three research questions: 1. What is the dental care access for children and young people (CYP) in care and care leavers? 2. What factors influence CYP in care and care leavers' access to dental care? 3. What pathways have been developed to improve access to oral health care for CYP in care and care leavers? METHODS: Five databases (Ovid MEDLINE, Ovid Embase, CINAHL, SocINDEX and Dentistry and Oral Sciences Source) and grey literature sources were systematically searched...
February 8, 2024: Dentistry Journal
https://read.qxmd.com/read/38388674/topical-minoxidil-and-dietary-supplement-for-the-treatment-of-chemotherapy-induced-alopecia-in-childhood-a-retrospective-cohort-study
#33
JOURNAL ARTICLE
Ji Won Lee, Jeewoo Kang, Jung Yoon Choi, Kyung Taek Hong, Hyoung Jin Kang, Ohsang Kwon
Chemotherapy-induced alopecia (CIA) is a common and debilitating condition in children, with limited research on its characteristics and treatment. Therefore, this study aims to describe the characteristics of pediatric patients with CIA and the treatment outcomes of topical minoxidil and L-cystine, medicinal yeast, and pantothenic acid complex-based dietary supplements (CYP). This retrospective cohort study analyzed data from patients who underwent high-dose conditioning chemotherapy followed by hematopoietic stem cell transplantation and were treated with either topical minoxidil or CYP for CIA between January 2011 and January 2022...
February 22, 2024: Scientific Reports
https://read.qxmd.com/read/38387892/-clinical-features-and-prognosis-of-acute-t-cell-lymphoblastic-leukemia-in-children-multi-center-data-analysis-in-fujian
#34
JOURNAL ARTICLE
Chun-Ping Wu, Yong-Zhi Zheng, Jian Li, Hong Wen, Kai-Zhi Weng, Shu-Quan Zhuang, Xing-Guo Wu, Xue-Ling Hua, Hao Zheng, Zai-Sheng Chen, Shao-Hua LE
OBJECTIVE: To evaluate the efficacy of acute T-cell lymphoblastic leukemia (T-ALL) in children and explore the prognostic risk factors. METHODS: The clinical data of 127 newly diagnosed children with T-ALL admitted to five hospitals in Fujian province from April 2011 to December 2020 were retrospectively analyzed, and compared with children with newly diagnosed acute precursor B-cell lymphoblastic leukemia (B-ALL) in the same period. Kaplan-Meier analysis was used to evaluate the overall survival (OS) and event-free survival (EFS), and COX proportional hazard regression model was used to evaluate the prognostic factors...
February 2024: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://read.qxmd.com/read/38379238/predictors-of-increased-affective-symptoms-and-suicidal-ideation-during-the-covid-19-pandemic-results-from-a-large-scale-study-of-14-271-thai-adults
#35
JOURNAL ARTICLE
Thitiporn Supasitthumrong, Michael Maes, Chavit Tunvirachaisakul, Teerayuth Rungnirundorn, Bo Zhou, Jing Li, Sorawit Wainipitapong, Anchalita Ratanajaruraks, Chaichana Nimnuan, Buranee Kanchanatawan, Trevor Thompson, Marco Solmi, Christoph Correll
BACKGROUND: Increasing data suggest emergent affective symptoms during the COVID-19 pandemic. OBJECTIVES: To study the impact of the COVID-19 pandemic on affective symptoms and suicidal ideation in Thai adults. METHODS: The Collaborative Outcomes Study on Health and Functioning during Infection Times uses non-probability sampling (chain referring and voluntary response sampling) and stratified probability sampling to identify risk factors of mental health problems and potential treatment targets to improve mental health outcomes during pandemics...
February 19, 2024: BMJ Ment Health
https://read.qxmd.com/read/38377698/healthy-aging-trajectories-and-their-predictors-among-chinese-older-adults-evidence-from-a-7-year-nationwide-prospective-cohort-study
#36
JOURNAL ARTICLE
Xu Wang, Jinzhao Xie, Menglin Shang, Ping Yin, Jing Gu
OBJECTIVES: This study aimed to identify healthy aging trajectories of Chinese older adults, and explore the factors contributing to these trajectories. METHODS: We used data from four waves (2011-2018) of China Health and Retirement Longitudinal Study. We developed a healthy aging metric based on the healthy aging framework of World Health Organization (WHO) and Bayesian multilevel item response theory (IRT) method. The healthy aging trajectories were identified using the latent class growth analysis...
January 15, 2024: Archives of Gerontology and Geriatrics
https://read.qxmd.com/read/38375111/folie-et-soci%C3%A3-t%C3%A3-eroding-the-body-mind-relationship-via-dysfunctional-paternalistic-systems
#37
JOURNAL ARTICLE
Matt Hudson, Nazish Idrees Chaudhary, Curtis Nordstrom
This theoretical perspective examines the proposition of shared complex trauma between a parent and child, arising from blurred relational boundaries and societal oppression, leading to inequality both at home and within the larger paternalistic system of society. Specifically, the focus is on living within a paternalistic, authoritarian system where rules are unjust, demanding obedience and compliance without questioning the behaviors of the authority. Individuals growing up in these circumstances are subject to adverse and emotionally overwhelming experiences, which lead to the creation of emotional memory images (EMIs)...
2024: Frontiers in Psychology
https://read.qxmd.com/read/38370947/childhood-trauma-and-bipolar-affective-disorder-is-there-a-linkage
#38
REVIEW
Vinay S Chauhan, Markanday Sharma, Kaushik Chatterjee, Jyoti Prakash, Kalpana Srivastava, Suprakash Chaudhury
Bipolar affective disorder (BPAD) is a major psychiatric illness impairing the quality of life. The etiology of BPAD is influenced by different factors possibly related to gene-environment interactions. Approximately 30% to 50% of individuals with BPAD have experienced some traumatic event in childhood. Serious adverse experiences that children may suffer early in life are often described as childhood trauma (CT). It includes physical, emotional, and sexual abuse and physical and emotional neglect. CT is linked with an elevated risk of developing BPAD...
November 2023: Industrial Psychiatry Journal
https://read.qxmd.com/read/38360044/high-dose-intravenous-immunoglobulin-versus-albumin-4-in-paediatric-toxic-shock-syndrome-a-randomised-controlled-feasibility-study
#39
JOURNAL ARTICLE
Aurélie Portefaix, Carole Dhelens, Morgan Recher, Fleur Cour-Andlauer, Jérôme Naudin, Guillaume Mortamet, Nicolas Joram, Pierre Tissières, Tiphanie Ginhoux, Behrouz Kassai, Florent Boutitie, Delphine Maucort-Boulch, Etienne Javouhey
PURPOSE: Toxic shock syndrome (TSS) is a rare disease responsible for significant morbidity and mortality. Intravenous immunoglobulin (IG) therapy in paediatric TSS could improve shock and organ failure, but more consistent efficacy and safety data are needed. Our objective was to determine whether a randomised clinical trial (RCT) assessing intravenous IG in TSS in children is feasible. METHODS: We performed a multicentre, feasibility, double-blind RCT assessing efficacy of high-dose intravenous IG versus albumin 4% (control group) within the first 12 hours of shock onset...
February 15, 2024: Archives of Disease in Childhood
https://read.qxmd.com/read/38347552/molecular-guided-therapy-for-the-treatment-of-patients-with-relapsed-and-refractory-childhood-cancers-a-beat-childhood-cancer-research-consortium-trial
#40
JOURNAL ARTICLE
Giselle L Saulnier Sholler, Genevieve Bergendahl, Elizabeth C Lewis, Jacqueline Kraveka, William Ferguson, Abhinav B Nagulapally, Karl Dykema, Valerie I Brown, Michael S Isakoff, Joseph Junewick, Deanna Mitchell, Jawhar Rawwas, William Roberts, Don Eslin, Javier Oesterheld, Randal K Wada, Devang Pastakia, Virginia Harrod, Kevin Ginn, Raya Saab, Kevin Bielamowicz, Jason Glover, Eugenia Chang, Gina K Hanna, Daniel Enriquez, Tyler Izatt, Rebecca F Halperin, Abigail Moore, Sara A Byron, William P D Hendricks, Jeffrey M Trent
BACKGROUND: Children with relapsed central nervous system (CNS tumors), neuroblastoma, sarcomas, and other rare solid tumors face poor outcomes. This prospective clinical trial examined the feasibility of combining genomic and transcriptomic profiling of tumor samples with a molecular tumor board (MTB) approach to make real‑time treatment decisions for children with relapsed/refractory solid tumors. METHODS: Subjects were divided into three strata: stratum 1-relapsed/refractory neuroblastoma; stratum 2-relapsed/refractory CNS tumors; and stratum 3-relapsed/refractory rare solid tumors...
February 12, 2024: Genome Medicine
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