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adverse childhood events

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https://www.readbyqxmd.com/read/29139608/current-state-of-screening-high-ace-youth-and-emerging-adults-in-primary-care
#1
Michelle Pardee, Elizabeth Kuzma, Chin Hwa Gina Y Dahlem, Nicole Boucher, Cynthia S Darling-Fisher
BACKGROUND AND PURPOSE: Trauma comes in many forms, including interpersonal, community, and institutional trauma. The adverse childhood event (ACE) studies demonstrated that adverse experiences in childhood can have a profound, cumulative impact on the course of health and development over a lifetime. It is critical for healthcare providers, such as nurse practitioners (NPs), working in primary care to screen adolescents and emerging adults for a history of ACEs and trauma. A review of current assessment tools used in assessing this population in health settings is needed to determine how screening for ACEs is being performed...
November 15, 2017: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29132074/robust-symptom-networks-in-recurrent-major-depression-across-different-levels-of-genetic-and-environmental-risk
#2
H M van Loo, C D Van Borkulo, R E Peterson, E I Fried, S H Aggen, D Borsboom, K S Kendler
BACKGROUND: Genetic risk and environmental adversity-both important risk factors for major depression (MD)-are thought to differentially impact on depressive symptom types and associations. Does heterogeneity in these risk factors result in different depressive symptom networks in patients with MD? METHODS: A clinical sample of 5784 Han Chinese women with recurrent MD were interviewed about their depressive symptoms during their lifetime worst episode of MD. The cases were classified into subgroups based on their genetic risk for MD (family history, polygenic risk score, early age at onset) and severe adversity (childhood sexual abuse, stressful life events)...
October 29, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29132070/sixteen-year-history-of-rituximab-therapy-for-1085-pemphigus-vulgaris-patients-a-systematic-review
#3
REVIEW
Soheil Tavakolpour, HamidReza Mahmoudi, Kamran Balighi, Robabeh Abedini, Maryam Daneshpazhooh
Pemphigus vulgaris (PV) is a rare autoimmune disease due to the production of pathogenic autoantibodies directed against desmoglein 1 and 3, usually affecting both skin and mucous membranes. Recently, rituximab, a chimeric IgG1 monoclonal antibody which targets the CD20 molecules have been regarded as a promising treatment for PV. In this study, a systematic review was conducted to conclude on how and which PV patients could benefit from rituximab infusion. Search in PubMed results in 114 relevant studies, which met the criteria...
November 10, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29129039/combined-diet-and-exercise-interventions-for-preventing-gestational-diabetes-mellitus
#4
REVIEW
Emily Shepherd, Judith C Gomersall, Joanna Tieu, Shanshan Han, Caroline A Crowther, Philippa Middleton
BACKGROUND: Gestational diabetes mellitus (GDM) is associated with a wide range of adverse health consequences for women and their infants in the short and long term. With an increasing prevalence of GDM worldwide, there is an urgent need to assess strategies for GDM prevention, such as combined diet and exercise interventions. This is an update of a Cochrane review that was first published in 2015. OBJECTIVES: To assess the effects of diet interventions in combination with exercise interventions for pregnant women for preventing GDM, and associated adverse health consequences for the mother and her infant/child...
November 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29119819/stories-of-survival-children-s-narratives-of-psychosocial-well-being-following-paediatric-critical-illness-or-injury
#5
Joseph C Manning, Pippa Hemingway, Sarah A Redsell
Survival from critical illness can expose children to an array of negative physical and psychological problems. While the perspective of parents and professionals have been well documented, there is limited understanding of how childhood critical care survivors make sense of their experiences in relation to psychosocial well-being. We aimed to explore long-term psychosocial well-being of childhood survivors of critical illness through their stories. A qualitative, exploratory study using serial in-depth interviews was employed...
September 2017: Journal of Child Health Care: for Professionals Working with Children in the Hospital and Community
https://www.readbyqxmd.com/read/29114060/ethics-rounds-death-after-pediatric-dental-anesthesia-an-avoidable-tragedy
#6
Helen Lee, Peter Milgrom, Colleen E Huebner, Philip Weinstein, Wylie Burke, Erika Blacksher, John D Lantos
Early childhood caries (ECC) is the single most common chronic childhood disease. In the treatment of ECC, children are often given moderate sedation or general anesthesia. An estimated 100 000 to 250 000 pediatric dental sedations are performed annually in the United States. The most common medications are benzodiazepines, opioids, local anesthetics, and nitrous oxide. All are associated with serious adverse events, including hypoxemia, respiratory depression, airway obstruction, and death. There is no mandated reporting of adverse events or deaths, so we don't know how often these occur...
November 7, 2017: Pediatrics
https://www.readbyqxmd.com/read/29102837/bdnf-val66met-polymorphism-life-stress-and-depression-a-meta-analysis-of-gene-environment-interaction
#7
REVIEW
Mingzhe Zhao, Lu Chen, Jiarun Yang, Dong Han, Deyu Fang, Xiaohui Qiu, Xiuxian Yang, Zhengxue Qiao, Jingsong Ma, Lin Wang, Shixiang Jiang, Xuejia Song, Jiawei Zhou, Jian Zhang, Mingqi Chen, Dong Qi, Yanjie Yang, Hui Pan
BACKGROUND: Depression is thought to be multifactorial in etiology, including genetic and environmental components. While a number of gene-environment interaction studies have been carried out, meta-analyses are scarce. The present meta-analysis aimed to quantify evidence on the interaction between brain-derived neurotrophic factor (BDNF) Val66Met polymorphism and stress in depression. METHODS: Included were 31 peer-reviewed with a pooled total of 21060 participants published before October 2016 and literature searches were conducted using PubMed, Wolters Kluwer, Web of Science, EBSCO, Elsevier Science Direct and Baidu Scholar databases...
October 16, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29094450/management-of-pediatric-psoriasis-with-acitretin-a-review
#8
REVIEW
Smriti Subedi, Qian Yu, Zeyu Chen, Yuling Shi
Psoriasis is a chronic inflammatory disease of the skin which can occur at any age-group. Psoriasis in childhood is not uncommon and has genetic susceptibility but usually, an environmental trigger such as infection is thought to initiate the disease process. Pediatric psoriasis has profound effects on both physical and psychosocial health of the patient. Treatment of mild psoriasis can be done with topical therapies but those which do not respond to topical therapies can be treated with phototherapy and systemic therapies...
November 1, 2017: Dermatologic Therapy
https://www.readbyqxmd.com/read/29083510/on-the-etiology-of-type-1-diabetes-physiological-growth-in-children-impacts-disease-progression
#9
REVIEW
Oskar Skog, Olle Korsgren
The prevailing view is that Type 1 Diabetes (T1D) develops as a consequence of a severe fall in beta-cell mass resulting from T-cell mediated autoimmunity. However, progression from islet autoantibody seroconversion to overt diabetes and finally to total loss of c-peptide production occurs in most affected subjects only slowly over many years or even decades. This slow disease progression should be viewed in relation to the total beta cell mass of only 0.2 - 1.5 g in non-diabetic adults. Focal lesions of acute pancreatitis with accumulation of leukocytes, often located around the ducts, are frequently observed in subjects with recent onset T1D and most patients display extensive periductal fibrosis, the end stage of inflammation...
October 30, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29066395/associations-between-prenatal-childhood-and-adolescent-stress-and-variations-in-white-matter-properties-in-young-men
#10
REVIEW
Sarah K G Jensen, Melissa Pangelinan, Lassi Björnholm, Anja Klasnja, Alexander Leemans, Mark Drakesmith, C J Evans, Edward D Barker, Tomáš Paus
OBJECTIVE: Previous studies have shown that both pre- and post-natal adversities, the latter including exposures to stress during childhood and adolescence, explain variations in structural properties of white matter (WM) in the brain. While previous studies have examined effects of independent stress exposures within one developmental period, such as childhood, we examine effects of stress across development using data from a prospective longitudinal study. More specifically, we ask how stressful events during prenatal development, childhood, and adolescence relate to variation in WM properties in early adulthood in men recruited from a birth cohort...
October 21, 2017: NeuroImage
https://www.readbyqxmd.com/read/29059253/a-novel-electronic-algorithm-using-host-biomarker-point-of-care-tests-for-the-management-of-febrile-illnesses-in-tanzanian-children-e-poct-a-randomized-controlled-non-inferiority-trial
#11
RANDOMIZED CONTROLLED TRIAL
Kristina Keitel, Frank Kagoro, Josephine Samaka, John Masimba, Zamzam Said, Hosiana Temba, Tarsis Mlaganile, Willy Sangu, Clotilde Rambaud-Althaus, Alain Gervaix, Blaise Genton, Valérie D'Acremont
BACKGROUND: The management of childhood infections remains inadequate in resource-limited countries, resulting in high mortality and irrational use of antimicrobials. Current disease management tools, such as the Integrated Management of Childhood Illness (IMCI) algorithm, rely solely on clinical signs and have not made use of available point-of-care tests (POCTs) that can help to identify children with severe infections and children in need of antibiotic treatment. e-POCT is a novel electronic algorithm based on current evidence; it guides clinicians through the entire consultation and recommends treatment based on a few clinical signs and POCT results, some performed in all patients (malaria rapid diagnostic test, hemoglobin, oximeter) and others in selected subgroups only (C-reactive protein, procalcitonin, glucometer)...
October 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29026276/five-cases-of-childhood-onset-graves-disease-treated-with-either-surgery-or-radio-iodine-therapy
#12
Kouki Tomari, Masahiro Goto, Aya Shimada, Hiroko Yagi, Yuka Nagashima, Yukihiro Hasegawa
There are three major therapeutic options for the treatment of Graves' disease (GD): antithyroid drugs (ATDs), thyroidectomy, and radio-iodine (RAI) therapy. ATDs are the initial treatment option for children. However, some pediatric GD patients who are initially treated with ATDs require other type of treatments later on. We reviewed the medical records of childhood-onset GD cases retrospectively to report the clinical course of patients who received either surgery or RAI therapy subsequent to treatment with ATDs...
2017: Clinical Pediatric Endocrinology: Case Reports and Clinical Investigations: Official Journal of the Japanese Society for Pediatric Endocrinology
https://www.readbyqxmd.com/read/29016809/longitudinal-assessment-of-late-onset-neurologic-conditions-in-survivors-of-childhood-central-nervous-system-tumors-a-childhood-cancer-survivor-study-report
#13
Elizabeth M Wells, Nicole J Ullrich, Kristy Seidel, Wendy Leisenring, Charles A Sklar, Gregory T Armstrong, Lisa Diller, Allison King, Kevin R Krull, Joseph P Neglia, Marilyn Stovall, Kimberly Whelan, Kevin C Oeffinger, Leslie L Robison, Roger J Packer
Background: Survivors of childhood central nervous system (CNS) tumors experience high rates of treatment-related neurologic sequelae. Whether survivors continue to be at increased risk for new events as they age is unknown. Methods: Adverse neurologic health conditions in 5-year survivors of CNS tumors from the Childhood Cancer Survivor Study (CCSS, n=1876) were evaluated longitudinally at a median 23.0 years from diagnosis, range 5.1 - 38.9; median age at last evaluation 30...
August 22, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/29016288/efficacy-and-safety-of-liposomal-amphotericin-b-for-visceral-leishmaniasis-in-children-and-adolescents-at-a-tertiary-care-center-in-bihar-india
#14
Krishna Pandey, Biplab Pal, Niyamat Ali Siddiqui, Vidya Nand Rabi Das, Krishna Murti, Chandra Shekhar Lal, Neena Verma, Rajendra Babu, Vahab Ali, Rakesh Kumar, Pradeep Das
Liposomal amphotericin B is being used increasingly to reduce the burden of kala-azar from the Indian subcontinent. There are studies which have evaluated efficacy and safety of liposomal amphotericin B for visceral leishmaniasis in all age groups. However, the only study that specifically addressed treatment of childhood visceral leishmaniasis did not include all ages or document renal and liver function. We, therefore, felt it was important to reassess the efficacy and safety of single dose liposomal amphotericin B in children and adolescents...
September 5, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28993444/immigrant-latino-children-and-the-limits-of-questionnaires-in-capturing-adverse-childhood-events
#15
COMMENT
Glenn Flores, Juan C Salazar
No abstract text is available yet for this article.
November 2017: Pediatrics
https://www.readbyqxmd.com/read/28992958/positive-childhood-experiences-predict-less-psychopathology-and-stress-in-pregnant-women-with-childhood-adversity-a-pilot-study-of-the-benevolent-childhood-experiences-bces-scale
#16
Angela J Narayan, Luisa M Rivera, Rosemary E Bernstein, William W Harris, Alicia F Lieberman
This pilot study examined the psychometric properties of the Benevolent Childhood Experiences (BCEs) scale, a new instrument designed to assess positive early life experiences in adults with histories of childhood maltreatment and other adversities. A counterpart to the Adverse Childhood Experiences (ACEs) questionnaire, the BCEs was developed to be multiculturally-sensitive and applicable regardless of socioeconomic position, urban-rural background, or immigration status. Higher levels of BCEs were hypothesized to predict lower levels of psychopathology and stress beyond the effects of ACES in a sample of ethnically diverse, low-income pregnant women...
October 6, 2017: Child Abuse & Neglect
https://www.readbyqxmd.com/read/28988558/childhood-abuse-and-psychotic-experiences-evidence-for-mediation-by-adulthood-adverse-life-events
#17
V Bhavsar, J Boydell, P McGuire, V Harris, M Hotopf, S L Hatch, J H MacCabe, C Morgan
AIMS: We have previously reported an association between childhood abuse and psychotic experiences (PEs) in survey data from South East London. Childhood abuse is related to subsequent adulthood adversity, which could form one pathway to PEs. We aimed to investigate evidence of mediation of the association between childhood abuse and PEs by adverse life events. METHODS: Data were analysed from the South East London Community Health Study (SELCoH, n = 1698). Estimates of the total effects on PEs of any physical or sexual abuse while growing up were partitioned into direct (i...
October 9, 2017: Epidemiology and Psychiatric Sciences
https://www.readbyqxmd.com/read/28983018/phase-1-study-of-the-anti-cd22-immunotoxin-moxetumomab-pasudotox-for-childhood-acute-lymphoblastic-leukemia
#18
MULTICENTER STUDY
Alan S Wayne, Nirali N Shah, Deepa Bhojwani, Lewis B Silverman, James A Whitlock, Maryalice Stetler-Stevenson, Weili Sun, Meina Liang, Jie Yang, Robert J Kreitman, Mark C Lanasa, Ira Pastan
Novel therapies are needed to overcome chemotherapy resistance for children with relapsed/refractory acute lymphoblastic leukemia (ALL). Moxetumomab pasudotox is a recombinant anti-CD22 immunotoxin. A multicenter phase 1 study was conducted to determine the maximum-tolerated cumulative dose (MTCD) and evaluate safety, activity, pharmacokinetics, and immunogenicity of moxetumomab pasudotox in children, adolescents, and young adults with ALL (N = 55). Moxetumomab pasudotox was administered as a 30-minute IV infusion at doses of 5 to 50 µg/kg every other day for 6 (cohorts A and B) or 10 (cohort C) doses in 21-day cycles...
October 5, 2017: Blood
https://www.readbyqxmd.com/read/28982528/childhood-adolescent-stressors-and-allostatic-load-in-adulthood-support-for-a-calibration-model
#19
Mark T Berg, Ronald L Simons, Ashley Barr, Steven R H Beach, Robert A Philibert
RATIONALE: Past research has established an association between childhood and adolescent stressors and elevated inflammatory and metabolic biomarkers in adulthood, but questions remain about the theoretical model most suited to explain this association. OBJECTIVE: This study examined alternative hypotheses from four theoretical models regarding the link between exposure to stressful early life circumstances and cumulative biological risk, or allostatic load, in adulthood...
November 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28977131/use-of-warfarin-in-pediatrics-clinical-and-pharmacological-characteristics
#20
Bruna Bergmann Santos, Isabela Heineck, Giovanna Webster Negretto
OBJECTIVE: To describe how children respond to oral anticoagulation with warfarin, verifying the influence of age, clinical condition, route of administration of warfarin and use of total parenteral nutrition (TPN), as well as to describe risk factors for the occurrence of thrombotic events (TE) in childhood. METHODS: A retrospective descriptive study including all patients ≤18 years old for whom warfarin was prescribed in a university hospital. Patients were divided according to clinical condition, age, route of medication administration and use of TPN...
September 21, 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
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