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Hidradenitis

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https://www.readbyqxmd.com/read/29344326/non-response-to-interleukin-1-antagonist-canakinumab-in-two-patients-with-refractory-pyoderma-gangrenosum-and-hidradenitis-suppurativa
#1
Natalie Z Sun, Teresa Ro, Puneet Jolly, Christopher J Sayed
Pyoderma gangrenosum and hidradenitis suppurativa are skin conditions characterized by an intense neutrophil-mediated inflammatory response that is often difficult to effectively treat. Successful use of interleukin (IL)-1β inhibition using canakinumab and anakinra has been reported in patients with concomitant pyoderma gangrenosum and hidradenitis suppurativa. We report two cases where targeted therapy with canakinumab failed to lead to improvement for patients with pyoderma gangrenosum and hidradenitis suppurativa...
September 2017: Journal of Clinical and Aesthetic Dermatology
https://www.readbyqxmd.com/read/29339240/prevalence-of-type-ii-diabetes-mellitus-among-patients-with-hidradenitis-suppurativa-in-the-united-states
#2
Amit Garg, Morgan Birabaharan, Andrew Strunk
BACKGROUND: Few studies have evaluated the relationship between hidradenitis suppurativa (HS) and diabetes mellitus (DM), and the existing data show conflicting results. OBJECTIVE: To determine prevalence of DM among HS patients, and identify at risk demographic subgroups. METHODS: Cross-sectional analysis identifying DM among HS and non-HS patients from a demographically heterogeneous population-based sample of over 50 million patients in the United States...
January 12, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29325465/prevalence-of-positive-quantiferon-gold-in-tube-testing-in-hidradenitis-suppurativa
#3
Tina Boortalary, Kanchan Misra, Sean McNish, Derek Jones, Victoria K Shanmugam
Hidradenitis suppurativa (HS) is a chronic, recurrent, inflammatory disease of the apocrine sweat glands. Tumor necrosis factor-alpha (TNF-α) inhibitors are commonly used to treat HS. However, prior to initiating therapy patients must be screened for mycobacterium tuberculosis (mTB) exposure. Several mTB screening tests based on interferon gamma release assays are commercially available, but the performance of these assays in the HS population is unknown. The purpose of this study was to investigate the performance of the QuantiFERON gold in-tube assay (QFT-GIT) in a cohort of patients with Hidradenitis suppurativa (HS)...
January 12, 2018: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/29322225/-surgical-treatment-options-for-hidradenitis-suppurativa-acne-inversa
#4
REVIEW
L Scholl, S Hessam, S Reitenbach, F G Bechara
Hidradenitis suppurativa/acne inversa (HS/AI) is a chronic inflammatory skin disease. Therapy consists of conservative and surgical treatment options. In Hurley stages II and III, surgical intervention is regarded as the method of choice for areas with irreversible tissue destruction. Resection techniques with different grades of invasiveness are described in the literature. Nevertheless, there is no generally accepted concept regarding resection and reconstruction techniques or specific postoperative care...
January 10, 2018: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/29314202/neutrophilic-superficial-eccrine-ductitis-proposal-of-a-new-disease-concept
#5
Hiroshi Nagai, Chikako Nishigori
A 3-year-old Japanese boy presented with a 3-month history of itchy erythematous papules on his trunk and forearms, the histologic findings of which were characterized by predominantly neutrophilic inflammation within and around the eccrine sweat ducts and obliteration and disruption of the superficial eccrine sweat ducts. Although the skin disorder had some clinical and histopathologic similarity to miliaria and neutrophilic eccrine hidradenitis, it was ultimately conformed to be neither disorder. Based on this and a case report in the Japanese literature of a 1-year-old boy with erythematous eruptions whose clinical and histopathologic findings were similar to those in our case, we propose the skin disorder in our case, referred to as "neutrophilic superficial eccrine ductitis," as a unique entity...
January 5, 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29300768/carotid-ultrasound-is-useful-for-the-cardiovascular-risk-stratification-in-patients-with-hidradenitis-suppurativa
#6
Marcos A González-López, Marina Lacalle, Cristina Mata, María López-Escobar, Alfonso Corrales, Raquel López-Mejías, Javier Rueda, M Carmen González-Vela, Miguel A González-Gay, Ricardo Blanco, José L Hernández
INTRODUCTION: Hidradenitis suppurativa (HS) is a chronic inflammatory cutaneous disease which has been associated with an increased risk of adverse cardiovascular (CV) outcomes. Adequate stratification of the CV risk is an issue of major importance in patients with HS. To analyze the usefulness of carotid ultrasound (US) assessment for the CV disease risk stratification compared with a traditional score, the Framingham risk score (FRS), in a series of patients with HS. METHODS: Cross-sectional study of 60 patients with HS without history of CV events, diabetes mellitus or chronic kidney disease...
2018: PloS One
https://www.readbyqxmd.com/read/29289722/effects-of-adalimumab-on-t-helper-17-lymphocyte-and-neutrophil-related-inflammatory-serum-markers-in-patients-with-moderate-to-severe-hidradenitis-suppurativa
#7
D Jiménez-Gallo, R de la Varga-Martínez, L Ossorio-García, C Collantes-Rodríguez, C Rodríguez, M Linares-Barrios
BACKGROUND: T-helper (Th)-17 lymphocytes and neutrophils are the main sources of the proinflammatory cytokines involved in the pathogenesis of hidradenitis suppurativa (HS). OBJECTIVES: This study aims to evaluate the improvement of the inflammatory serum markers (ISM) levels in patients with moderate-to-severe HS who receive adalimumab. METHODS: Nineteen moderate-to-severe HS patients were prospectively recruited. Each of the patients received 40 mg of adalimumab weekly...
December 28, 2017: Cytokine
https://www.readbyqxmd.com/read/29284150/men-main-victims-of-hidradenitis-suppurativa-a-prospective-cohort-study
#8
Hemmat Maghsoudi, Hojjat Almasi, Mahmood Reza Miri Bonjar
BACKGROUND: hidradenitis suppurativa (HS) is a chronic inflammatory disease presenting as painful subcutaneous nodules, characterized by multiple abscess, inter-networking sinus tracts. We present the option of surgical treatment involving wide surgical excision and methods of reconstruction as well as the rate of recurrence. METHOD: This study reviewed 44 sites in 21 patients with moderate to extensive HS treated surgically in our hospital from 2000 to 2016, with a follow up of at least 24 months...
December 25, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29262280/clinical-diagnosis-of-hidradenitis-suppurativa
#9
Anna Beltrame, Silvia Staffolani
A 27-year-old man presented to the Center for Tropical Diseases at our hospital with a 2-year history of acne and the recurrence of multiple painful lesions in the genital and perineal areas. He had previously been treated with multiple courses of antibiotic agents and with surgical treatments..
December 21, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/29249247/-what-s-new-in-instrumental-dermatology
#10
V Chaussade
This "What's new in instrumental dermatology" dedicated skin surgeryis based upon a 2015-2017 literature analysis. The excision of skin cancers is an important part of surgical dermatology. Will artificial intelligence and new drug be able to face the increasing need for therapy? Wrong-site surgery is due to multiple factors. Photographs of biopsy site and short time between biopsy and surgery decrease postponement of surgery and wrong-site surgery. Noninvasive imaging technologies are improving and help to delineate skin tumors and increase the probability of complete tumor removal...
December 2017: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29247661/identification-of-atorvastatin-for-moderate-to-severe-hidradenitis-through-drug-repositioning-using-public-gene-expression-dataset
#11
Karen Y Kuo, Hyunje Grace Cho, Kavita Sarin
No abstract text is available yet for this article.
December 13, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29241794/drug-associated-hidradenitis-suppurativa-a-systematic-review-of-case-reports
#12
John W Frew, Dunja A Vekic, Jane A Woods, Geoffrey D Cains
No abstract text is available yet for this article.
January 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29241793/hidradenitis-suppurativa-burden-of-disease-tool-pilot-testing-of-a-disease-specific-quality-of-life-questionnaire
#13
Joanie Pinard, Ruth Ann Vleugels, Cara Joyce, Joseph F Merola, Mital Patel
No abstract text is available yet for this article.
January 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29241760/miscellaneous-skin-disease-and-the-metabolic-syndrome
#14
Sila Seremet, Mehmet Salih Gurel
The link between the metabolic syndrome (MetS) and skin diseases is increasingly important, with new associations being discovered. The association between MetS and psoriasis or MetS and hidradenitis suppurativa is well known, although the relationship between MetS and various autoimmune or inflammatory diseases has only recently attracted interest. Some inflammatory skin diseases, such as vitiligo, scleredema, recurrent aphthous stomatitis, Behçet disease, rosacea, necrobiosis lipoidica, granuloma annulare, skin tags, knuckle pads, and eruptive xanthomas, have possible associations with MetS...
January 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29241759/genetics-and-the-metabolic-syndrome
#15
Emma Fanning, Donal O'Shea
Originally coined as "syndrome X" in 1988 by Gerald Reaven (1928), the metabolic syndrome (MetS) encompasses a constellation of risk factors, the coincidence of which amounts to an increased cardiovascular and diabetic risk. Rising numbers of dermatoses are being recognized as cutaneous markers of MetS. Dermatologists should look beyond treating the cutaneous condition and quantify the associated increase in cardiovascular risk. The original dermatosis associated with obesity was acanthosis nigricans-described in 1889 by Paul Gerson Unna (1850-1929) and Sigmund Pollitzer (1859-1937)...
January 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29241757/cutaneous-manifestations-of-obesity-and-themetabolic-syndrome
#16
Tuğba Kevser Uzuncakmak, Necmettin Akdeniz, Ayse Serap Karadag
The cutaneous manifestations of obesity and the associated metabolic syndrome (MetS) may present with a wide variety of cutaneous findings, including acanthosis nigricans, acrochordon, cellulitis, psoriasis, hidradenitis suppurativa, acne, and hirsutism. Being aware of such clinical signs and the underlying systemic disorders may facilitate earlier diagnoses, thereby permitting earlier of therapy initiation and prevention of long-term sequelae. In this process, dermatologists are key figures in the early detection of MetS and its clinical manifestations...
January 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29241751/hidradenitis-suppurativa-and-the-metabolic-syndrome
#17
Tulin Ergun
The association of the metabolic syndrome (MetS) and its components with immune-mediated chronic inflammatory disorders has attracted much interest within the last two decades. In addition to the well-established association of psoriasis with MetS, recent data point to an association between MetS and hidradenitis suppurativa, as well. The association of hidradenitis suppurativa with MetS and its components, such as diabetes, obesity, and dyslipidemia, has been consistently identified in controlled studies. This relationship is not only limited to older individuals but also applicable to younger patients and those with mild disease...
January 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29241747/pathophysiology-of-the-metabolic-syndrome
#18
Emma McCracken, Monica Monaghan, Shiva Sreenivasan
The metabolic syndrome-otherwise called syndrome X, insulin resistance syndrome, Reaven syndrome, and "the deadly quartet"-is the name given to the aggregate of clinical conditions comprising central and abdominal obesity, systemic hypertension, insulin resistance (or type 2 diabetes mellitus), and atherogenic dyslipidemia. It is a prothrombotic and proinflammatory state characterized by increased inflammatory cytokine activity. In addition to inflammatory dermatoses such as psoriasis, lichen planus, and hidradenitis suppurativa, metabolic syndrome is also commonly associated with accelerated atherosclerotic cardiovascular disease, hyperuricemia/gout, chronic kidney disease, and obstructive sleep apnea...
January 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29239728/wound-healing-of-cutaneous-substance-losses-based-on-infectious-inflammatory-and-traumatic-skin-disorders-the-experience-of-a-center
#19
K Khoshim, B Hersant, C Hotz, M SidAhmed-Mezi, J P Meningaud
INTRODUCTION: There is no reference available concerning the standard healing time based on dermatological diseases responsible for cutaneous substance losses. The aim of our study was to assess the healing time after surgical debridement of necrotizing fasciitis (NF), hidradenitis suppurativa (HS) and skin necrosis due to trauma (SNT) based on multiples existing co-morbidities among these patients to provide surgeons with accurate scientific data in order to inform and educate patients and nurses who are practicing care under the supervision of the surgeon...
November 24, 2017: Annales de Chirurgie Plastique et Esthétique
https://www.readbyqxmd.com/read/29231053/the-contribution-of-malodour-in-quality-of-life-of-patients-with-hidradenitis-suppurativa
#20
Afsaneh Alavi, Delaram Farzanfar, Rosa Kyuwon Lee, Dalal Almutairi
BACKGROUND: Malodourous discharge in patients with hidradenitis suppurativa (HS) has a strong psychosocial impact and is often reported as a source of embarrassment, low self-esteem, social stigma, and barriers to interpersonal relationships. Malodour is a maker of bacterial colonization, and its role in HS is understudied. OBJECTIVES: The aim of this study is to assess the relationship between severity of malodourous discharge and quality-of-life impairment in patients with HS...
December 1, 2017: Journal of Cutaneous Medicine and Surgery
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