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https://www.readbyqxmd.com/read/27912236/prognostic-role-of-pten-gene-expression-in-breast-cancer-patients-from-north-east-iran
#1
Rahim Golmohammadi, Mohammad Hassan Rakhshani, Ali Reza Moslem, Akbar Pejhan
Background: PTEN protein is one of the most important tumour suppressor factors which is detectable by immunohistochemistry. The goal of the present study was to investigate the prognostic role of PTEN gene expression in breast cancer patients. Materials and Methods: This descriptive-analytical study was conducted on 100 breast cancer patients referred to Sabzevar hospitals in the north-east of Iran between 2010 and 2011, who were followed up to 2015. PTEN gene expression in tissue samples was determined using specific monoclonal antibodies and data were analyzed using Chi-square test and Fisher’s exact test...
January 9, 2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27911404/using-capillary-electrophoresis-to-quantify-organic-acids-from-plant-tissue-a-test-case-examining-coffea-arabica-seeds
#2
Michael Joe Vaughan, Ann Chanon, Joshua J Blakeslee
Carboxylic acids are organic acids containing one or more terminal carboxyl (COOH) functional groups. Short chain carboxylic acids (SCCAs; carboxylic acids containing three to six carbons), such as malate and citrate, are critical to the proper functioning of many biological systems, where they function in cellular respiration and can serve as indicators of cell health. In foods, organic acid content can have significant impact on taste, with increased SCCA levels resulting in a sour or "acid" taste. Because of this, methods for the rapid analysis of organic acid levels are of particular interest to the food and beverage industries...
November 12, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27911392/optogenetic-random-mutagenesis-using-histone-minisog-in-c-elegans
#3
Kentaro Noma, Yishi Jin
Forward genetic screening in model organisms is the workhorse to discover functionally important genes and pathways in many biological processes. In most mutagenesis-based screens, researchers have relied on the use of toxic chemicals, carcinogens, or irradiation, which requires designated equipment, safety setup, and/or disposal of hazardous materials. We have developed a simple approach to induce heritable mutations in C. elegans using germline-expressed histone-miniSOG, a light-inducible potent generator of reactive oxygen species...
November 14, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27892666/mantle-cell-lymphoma-a-north-indian-tertiary-care-centre-experience
#4
Chandan Krushna Das, Ajay Gogia, Lalit Kumar, Atul Sharma, Mehar Chand Sharma, Saumya Ranjan Mallick
Background: Mantle cell lymphoma (MCL) is an aggressive non-Hodgkin’s lymphoma, with a pathognomonic chromosomal translocation t (11;14). Prognosis is uniformly dismal but there is a paucity of information on MCL from India. Materials and methods: We retrospectively analysed clinicopathological information on all treated patients with MCL at our centre. STATA 14.0 was used for analysis. Survival was assessed by Kaplan-Meier analysis and the Cox’s proportional hazards method. Statistical significance was defined as a P value of < 0...
January 10, 2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27889215/benzotriazole-type-ultraviolet-stabilizers-and-antioxidants-in-plastic-marine-debris-and-their-new-products
#5
Manviri Rani, Won Joon Shim, Gi Myung Han, Mi Jang, Young Kyoung Song, Sang Hee Hong
Ultraviolet stabilizers (UVSs) and antioxidants are the most widely used additives in plastics to enhance the lifetime of polymeric materials. There is growing interest in the roles of plastic marine debris and microplastics as source or vector of toxic substances to marine environment and organisms. However, there is limited information available on plastic associated chemicals, particularly additive chemicals. Therefore, to evaluate their extent of exposure from plastics to the marine environment, we determined UVSs and antioxidants in plastic debris (n=29) collected from beaches along with their corresponding new plastic products in markets (n=27) belonging to food, fisheries, and general use...
November 23, 2016: Science of the Total Environment
https://www.readbyqxmd.com/read/27877848/towards-sensible-toxicity-testing-for-nanomaterials-proposal-for-the-specification-of-test-design
#6
Annegret Potthoff, Mirco Weil, Tobias Meißner, Dana Kühnel
During the last decade, nanomaterials (NM) were extensively tested for potential harmful effects towards humans and environmental organisms. However, a sound hazard assessment was so far hampered by uncertainties and a low comparability of test results. The reason for the low comparability is a high variation in the (1) type of NM tested with regard to raw material, size and shape and (2) procedures before and during the toxicity testing. This calls for tailored, nanomaterial-specific protocols. Here, a structured approach is proposed, intended to lead to test protocols not only tailored to specific types of nanomaterials, but also to respective test system for toxicity testing...
December 2015: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27877221/the-impact-of-diabetes-on-the-risk-of-prostate-cancer-development-according-to-body-mass-index-a-10-year-nationwide-cohort-study
#7
Jin Bong Choi, Hyong Woo Moon, Young Hyun Park, Woong Jin Bae, Hyuk Jin Cho, Sung-Hoo Hong, Ji Youl Lee, Sae Woong Kim, Kyung-Do Han, U-Syn Ha
Purpose: We examined the association between obesity and prostate cancer both with and without diabetic patients included in the analysis using nationally representative data of the Korean population from the National Health Insurance System (NHIS). Materials and Methods: Of the 424,712 participants who underwent health examinations in 2002-2008, 139,519 men ≥40 years old and without prostate cancer were followed from the beginning of 2002 to the end of 2012. Multivariate adjusted Cox regression analysis was conducted to examine the hazard ratio (HR) and 95% confidence interval (CI) for the association between prostate cancer and body mass index (BMI) both with and without diabetes...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27876240/variable-neighborhood-search-to-solve-the-vehicle-routing-problem-for-hazardous-materials-transportation
#8
Gustavo Alfredo Bula, Caroline Prodhon, Fabio Augusto Gonzalez, H Murat Afsar, Nubia Velasco
This work focuses on the Heterogeneous Fleet Vehicle Routing problem (HFVRP) in the context of hazardous materials (HazMat) transportation. The objective is to determine a set of routes that minimizes the total expected routing risk. This is a nonlinear function, and it depends on the vehicle load and the population exposed when an incident occurs. Thus, a piecewise linear approximation is used to estimate it. For solving the problem, a variant of the Variable Neighborhood Search (VNS) algorithm is employed...
November 9, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27875717/comparative-study-on-the-mobility-and-speciation-of-heavy-metals-in-ashes-from-co-combustion-of-sewage-sludge-dredged-sludge-and-rice-husk
#9
Teng Wang, Yongjie Xue, Min Zhou, Yunjuan Yuan, Suyun Zhao, Gang Tan, Xian Zhou, Junjun Geng, Shaopeng Wu, Haobo Hou
The co-combustion of sludge (sewage and dredged sludge) with rice husk is expected to become a trend because of its economic and environmental benefits. However, the massive residues from the co-combustion process and the mobility of heavy metals (HMs) warrant special attention. The basic performance and environmental properties of the trace elements (Cr, Cu, Fe, Mn, Ba and Zn) from the co-combustion ashes were studied to promote the further utilization of these materials. These ashes have a shell particle shape, high specific area, high amorphous content and low crystalline phase content...
November 19, 2016: Chemosphere
https://www.readbyqxmd.com/read/27875105/renal-cell-carcinoma-comparison-of-renal-nephrometry-and-padua-scores-with-maximum-tumor-diameter-for-prediction-of-local-recurrence-after-thermal-ablation
#10
Aaron W P Maxwell, Grayson L Baird, Jason D Iannuccilli, William W Mayo-Smith, Damian E Dupuy
Purpose To evaluate the performance of the radius, exophytic or endophytic, nearness to collecting system or sinus, anterior or posterior, and location relative to polar lines (RENAL) nephrometry and preoperative aspects and dimensions used for anatomic classification (PADUA) scoring systems and other tumor biometrics for prediction of local tumor recurrence in patients with renal cell carcinoma after thermal ablation. Materials and Methods This HIPAA-compliant study was performed with a waiver of informed consent after institutional review board approval was obtained...
November 22, 2016: Radiology
https://www.readbyqxmd.com/read/27869522/current-aspects-of-salmonella-contamination-in-the-us-poultry-production-chain-and-the-potential-application-of-risk-strategies-in-understanding-emerging-hazards
#11
Kalavathy Rajan, Zhaohao Shi, Steven C Ricke
One of the leading causes of foodborne illness in poultry products is Salmonella enterica. Salmonella hazards in poultry may be estimated and possible control methods modeled and evaluated through the use of quantitative microbiological risk assessment (QMRA) models and tools. From farm to table, there are many possible routes of Salmonella dissemination and contamination in poultry. From the time chicks are hatched through growth, transportation, processing, storage, preparation, and finally consumption, the product could be contaminated through exposure to different materials and sources...
November 21, 2016: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/27869364/assessing-the-reliability-of-ecotoxicological-studies-an-overview-of-current-needs-and-approaches
#12
Cta Moermond, A Beasley, R Breton, M Junghans, R Laskowski, K Solomon, H Zahner
In general, reliable studies are well designed, performed, and enough details on study design and performance are reported to assess the study. For hazard and risk assessment in various legal frameworks, many different types of ecotoxicity studies need to be evaluated for reliability. These studies vary in study design, methodology, quality, and in the level of detail reported (e.g., reviews, peer-reviewed research papers, or industry-sponsored studies documented under Good Laboratory Practice (GLP) guidelines)...
November 21, 2016: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/27866617/synthesis-of-cds-nanoparticles-from-cadmium-sulfate-solutions-using-the-extracellular-polymeric-substances-of-b-licheniformis-as-stabilizing-agent
#13
Mehran Bakhshi, Mohammad Raouf Hosseini
Mining and hydrometallurgical industries produce large amounts of hazardous metal sulfate solutions as a by-product which can be recycled and exploited to produce valuable and advanced materials. Here, for the first time, extracellular polymeric substances of Bacillus licheniformis were applied as biosurfactants to synthesize quantum dots of cadmium sulfide from pure artificial and impure industrial cadmium sulfate solutions. The bacterial biopolymers stabilized the generated crystalline nuclei as colloidal dots and prevented their further growth or agglomeration...
December 2016: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/27863580/hospital-decontamination-what-nurses-need-to-know
#14
REVIEW
Brent Cox
Incidents involving the release of hazardous materials challenge medical providers with safely, quickly, and correctly removing contaminants from the victim. While doing so, the safety of the first receiver, current patients, bystanders, as well as the victim all have to be considered. Key challenges with hospital decontamination include, but are not limited to, selection of team members, training protocols, employee turnover, and funding. Best practices, based on the available literature and evidence, include administration buy-in and support; strong policy and procedure documentation; equipment maintenance programs; and team member recruitment, retention, and education...
December 2016: Nursing Clinics of North America
https://www.readbyqxmd.com/read/27863192/treatment-of-children-and-adolescents-with-metastatic-medulloblastoma-and-prognostic-relevance-of-clinical-and-biologic-parameters
#15
André O von Bueren, Rolf-Dieter Kortmann, Katja von Hoff, Carsten Friedrich, Martin Mynarek, Klaus Müller, Tobias Goschzik, Anja Zur Mühlen, Nicolas Gerber, Monika Warmuth-Metz, Niels Soerensen, Frank Deinlein, Martin Benesch, Isabella Zwiener, Robert Kwiecien, Andreas Faldum, Udo Bode, Gudrun Fleischhack, Volker Hovestadt, Marcel Kool, David Jones, Paul Northcott, Joachim Kuehl, Stefan Pfister, Torsten Pietsch, Stefan Rutkowski
Purpose To assess an intensified treatment in the context of clinical and biologic risk factors in metastatic medulloblastoma. Patients and Methods Patients (4 to 21 years old, diagnosed between 2001 and 2007) received induction chemotherapy, dose-escalated hyperfractionated craniospinal radiotherapy, and maintenance chemotherapy. Subgroup status and other biologic parameters were assessed. Results In 123 eligible patients (median age, 8.2 years old; median follow-up, 5.38 years), 5-year event-free survival (EFS) and overall survival (OS) were 62% (95% CI, 52 to 72) and 74% (95% CI, 66 to 82), respectively...
December 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27862114/a-bayesian-model-and-stochastic-exposure-dose-estimation-for-relative-exposure-risk-comparison-involving-asbestos-containing-dropped-ceiling-panel-installation-and-maintenance-tasks
#16
Fred W Boelter, Yulin Xia, Jacob D Persky
Assessing exposures to hazards in order to characterize risk is at the core of occupational hygiene. Our study examined dropped ceiling systems commonly used in schools and commercial buildings and lay-in ceiling panels that may have contained asbestos prior to the mid to late 1970s. However, most ceiling panels and tiles do not contain asbestos. Since asbestos risk relates to dose, we estimated the distribution of eight-hour TWA concentrations and one-year exposures (a one-year dose equivalent) to asbestos fibers (asbestos f/cc-years) for five groups of workers who may encounter dropped ceilings: specialists, generalists, maintenance workers, nonprofessional do-it-yourself (DIY) persons, and other tradespersons who are bystanders to ceiling work...
November 10, 2016: Risk Analysis: An Official Publication of the Society for Risk Analysis
https://www.readbyqxmd.com/read/27847251/removal-of-harmful-alga-chattonella-marina-by-recyclable-natural-magnetic-sphalerite
#17
Bo Wang, Dan Wu, Ka Him Chu, Liqun Ye, Ho Yin Yip, Zhonghua Cai, Po Keung Wong
Fish-killing harmful algal blooms (HABs) of Chattonella marina causes serious hazards and risks to fish farming and environment throughout the world. At present, it is necessary to explore cost-effective and recyclable materials for controlling C. marina blooms to reduce the cost and control the potential side effect to the environment. A novel earth-abundant natural magnetic sphalerite (NMS) for removing C. marina was systematically investigated, including the effect of NMS dosage, temperature, pH and salinity on algal removal efficiency...
November 9, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/27846238/uptake-of-cadmium-lead-and-arsenic-by-tenebrio-molitor-and-hermetia-illucens-from-contaminated-substrates
#18
H J van der Fels-Klerx, L Camenzuli, M K van der Lee, D G A B Oonincx
Insects have potential as a novel source of protein in feed and food production in Europe, provided they can be used safely. To date, limited information is available on the safety of insects, and toxic elements are one of the potential hazards of concern. Therefore, we aimed to investigate the potential accumulation of cadmium, lead and arsenic in larvae of two insect species, Tenebrio molitor (yellow mealworm) and Hermetia illucens (black soldier fly), which seem to hold potential as a source of food or feed...
2016: PloS One
https://www.readbyqxmd.com/read/27844421/environmental-impacts-of-tobacco-product-waste-international-and-australian-policy-responses
#19
REVIEW
Lucinda A Wallbank, Ross MacKenzie, Paul J Beggs
The health risks of tobacco consumption are well established, but there is less awareness of the global environmental impacts of smoking. The by-products of the 6.3 trillion cigarettes smoked annually are filters (butts) that contain benzene, nicotine, cadmium, and dozens of other chemicals. It is estimated that between one- and two-thirds of all filters are discarded on roads, pavements, and green spaces. Butt litter as an environmental and public health hazard is a relatively new field of study, but recent research and findings have clear global implications...
November 14, 2016: Ambio
https://www.readbyqxmd.com/read/27842971/application-of-ich-q9-quality-risk-management-tools-for-advanced-development-of-hot-melt-coated-multiparticulate-systems
#20
Elena Stocker, Karin Becker, Siddhi Hate, Roland Hohl, Wolfgang Schiemenz, Stephan Sacher, Andreas Zimmer, Sharareh Salar-Behzadi
This study aimed to apply quality risk management based on the The International Conference on Harmonisation guideline Q9 for the early development stage of hot melt coated multiparticulate systems for oral administration. N-acetylcysteine crystals were coated with a formulation composing tripalmitin and polysorbate 65. The critical quality attributes (CQAs) were initially prioritized using failure mode and effects analysis. The CQAs of the coated material were defined as particle size, taste-masking efficiency, and immediate release profile...
November 11, 2016: Journal of Pharmaceutical Sciences
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