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https://www.readbyqxmd.com/read/29775648/towards-a-quantitative-model-to-predict-the-toxicity-pathogenicity-potential-of-mineral-fibers
#1
Alessandro F Gualtieri
A number of mineral fibers represent a health hazard because they are classified as cancer-causing chemical/physical toxicants upon (chronic) dust inhalation. Although in the last decades they have been the subject of intensive multidisciplinary investigations, the mechanisms by which mineral fibers induce toxic and pathogenic adverse effects on human health and environment are not yet fully understood. The major intricacy of the biological approach that prevents the design of a conclusive shared model of behavior of mineral fibers in a biological system stems from their very nature with intrinsic variability in chemical, molecular, structural and morphometric parameters, biodurability and surface reactivity...
May 15, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29773372/bionanocomposites-materials-for-food-packaging-applications-concepts-and-future-outlook
#2
REVIEW
Ahmed M Youssef, Samah M El-Sayed
Bionanocomposites materials open a chance for the usage of novel, high performance, lightweight, and ecofriendly composite materials making them take place the traditional non-biodegradable plastic packaging materials. Biopolymers like polysaccharides such as chitosan (CS), carboxymethyl cellulose (CMC), starch and cellophane could be used to resolve environmental hazards owing to their biodegradability and non-toxicity. In addition these advantages, polysaccharides have some disadvantages for example poor mechanical properties and low resistance to water...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29772341/development-of-an-auto-phase-separable-and-reusable-graphene-oxide-potato-starch-based-cross-linked-bio-composite-adsorbent-for-removal-of-methylene-blue-dye
#3
Amartya Bhattacharyya, Bhaskar Banerjee, Soumitra Ghorai, Dipak Rana, Indranil Roy, Gunjan Sarkar, Nayan Ranjan Saha, Sriparna De, Tapas Kumar Ghosh, Sourav Sadhukhan, Dipankar Chattopadhyay
In this work, we report the development of a cross-linked bio-composite consisting of graphene oxide, potato starch, cross-linker glutaraldehyde and its application to adsorption of the industrial dye, methylene blue, from aqueous solution. The inexpensiveness, non-hazardous nature and easy bio-degradability are the major reasons for the selection of starch material as one of the components of the bio-composite. The bio-composite has been characterized by FTIR, SEM, XRD, particle size and zeta potential analysis...
May 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29772259/photocatalytic-production-of-hydroxyl-radicals-by-commercial-tio-2-nanoparticles-and-phototoxic-hazard-identification
#4
Ying Tang, Rui Cai, Ding Cao, Xue Kong, Yongbo Lu
This study identifies the phototoxic potential of commercial titanium dioxide nanoparticles (TiO2 NPs) used in sunscreens and consumer products by employing a tiered testing approach comprising physicochemical, in vitro and ex vivo tests. Our results revealed that all the test samples of TiO2 NPs, varied in surface coating, crystallinity and primary particle size, produced hydroxyl radicals upon UVA photoexcitation as determined by electron spin resonance (ESR) spectroscopy. Their phototoxic potentials were assessed first by combining the validated 3T3 neutral red uptake phototoxicity test and red blood cell phototoxicity test and subsequently in ex vivo models of chick chorioallantoic membrane (CAM) and reconstructed human 3D skin model (H3D)...
May 14, 2018: Toxicology
https://www.readbyqxmd.com/read/29769737/next-generation-biocontainment-systems-for-engineered-organisms
#5
REVIEW
Jeong Wook Lee, Clement T Y Chan, Shimyn Slomovic, James J Collins
The increasing use of engineered organisms for industrial, clinical, and environmental applications poses a growing risk of spreading hazardous biological entities into the environment. To address this biosafety issue, significant effort has been invested in creating ways to confine these organisms and transgenic materials. Emerging technologies in synthetic biology involving genetic circuit engineering, genome editing, and gene expression regulation have led to the development of novel biocontainment systems...
May 16, 2018: Nature Chemical Biology
https://www.readbyqxmd.com/read/29766207/risks-and-prevention-of-surgical-fires-a-systematic-review
#6
I Kezze, N Zoremba, R Rossaint, A Rieg, M Coburn, G Schälte
Surgically induced fire is a life-threatening hazard; this topic has received little attention, although only 3 factors, the so-called fire triad, are needed for surgical fires to occur: an oxidizer, fuel and an ignition source. This systematic review aims to determine the impact of each component and to delegate every staff member an area of responsibility, thus ensuring patient health through prevention or protection. The trial was registered in Prospero CRD42018082656. A database search of eligible, preferably evidence-based studies was conducted...
May 15, 2018: Der Anaesthesist
https://www.readbyqxmd.com/read/29764099/assessment-of-treatment-field-isolation-during-scaling-root-planing-and-rinsing
#7
Michel Gigandet, Deborah Hofer, Thomas Attin, Philipp Sahrmann, Patrick R Schmidlin
Aim: Intensive application of highly concentrated antimicrobials during scaling and root planing may be hazardous if swallowed in quantity. This study evaluates two dental isolation systems for fluid leakage in conjunction with a sham treatment of scaling and root planing. Materials and methods: Eight volunteers were randomly assigned to wear a conventional rubber dam (RD) and a combined suction and isolation device (IsoLite® system [IL]) alternatively on contralateral maxillary and mandibular quadrants. RD was cut between the canine and the first molar and was fixed on the first molar with a rubber dam clamp and with a tissue adhesive (Histoacryl) on the gingiva...
May 16, 2018: Swiss Dental Journal
https://www.readbyqxmd.com/read/29762095/ct-based-visual-classification-of-emphysema-association-with-mortality-in-the-copdgene-study
#8
David A Lynch, Camille M Moore, Carla Wilson, Dipti Nevrekar, Theodore Jennermann, Stephen M Humphries, John H M Austin, Philippe A Grenier, Hans-Ulrich Kauczor, MeiLan K Han, Elizabeth A Regan, Barry J Make, Russell P Bowler, Terri H Beaty, Douglas Curran-Everett, John E Hokanson, Jeffrey L Curtis, Edwin K Silverman, James D Crapo
Purpose To determine whether visually assessed patterns of emphysema at CT might provide a simple assessment of mortality risk among cigarette smokers. Materials and Methods Of the first 4000 cigarette smokers consecutively enrolled between 2007 and 2011 in this COPDGene study, 3171 had data available for both visual emphysema CT scores and survival. Each CT scan was retrospectively visually scored by two analysts using the Fleischner Society classification system. Severity of emphysema was also evaluated quantitatively by using percentage lung volume occupied by low-attenuation areas (voxels with attenuation of -950 HU or less) (LAA-950)...
May 15, 2018: Radiology
https://www.readbyqxmd.com/read/29762013/determination-of-hexavalent-chromium-fractions-in-plastics-using-laboratory-based-high-resolution-x-ray-emission-spectroscopy
#9
Evan P Jahrman, Gerald T Seidler, John R Sieber
Cr(VI) is a well-known human carcinogen with many water-soluble moieties. Its presence in both natural and man-made substances poses a risk to public health, especially when contamination of ground water is possible. This has led the European Union and other jurisdictions to include Cr(VI) in restriction of hazardous substances (RoHS) regulations. However, for several important industrial and commercial purposes, analytical capability to characterize Cr(VI) is known to be insufficient for regulatory purposes...
May 15, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29759047/histological-predictors-of-renal-outcome-in-lupus-nephritis-the-importance-of-tubulointerstitial-lesions-and-scoring-of-glomerular-lesions
#10
B Obrișcă, R Jurubiță, A Andronesi, B Sorohan, C Achim, R Bobeica, M Gherghiceanu, E Mandache, G Ismail
Introduction Lupus nephritis (LN) affects nearly 60% of patients with systemic lupus erythematosus and up to 30% of them will progress to end-stage renal disease (ESRD), despite receiving aggressive immunosuppressive therapy. The prognostic value of ISN/RPS classification is controversial. Therefore, we aimed to identify clinical and pathological predictors of outcome in LN patients independent of this classification. Material and methods Thirty-seven patients with LN who underwent percutaneous kidney biopsy between 1997 and 2016 were included in this study...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29754090/hazard-potential-of-widespread-but-hidden-historic-offshore-heavy-metal-pb-zn-contamination-gulf-of-cadiz-spain
#11
Till J J Hanebuth, Mary Lee King, Isabel Mendes, Susana Lebreiro, Francisco J Lobo, Ferdinand K Oberle, Laura Antón, Paulo Alves Ferreira, Maria Isabel Reguera
Natural and human-induced seabed sediment disturbances affect wide areas of the global coastal ocean. These recurrent to chronic disturbances mobilize significant amounts of material, including substances that have the potential to significantly harm the environment once re-released. This very challenging issue is difficult to deal with if sub-surface contaminant concentrations are unknown. Based on the analysis of 11 new, up to 5-m long sediment cores taken offshore in the Gulf of Cadiz, the contamination history (using the trace elements lead and zinc) is well documented over major parts of the gulf...
May 10, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29751174/removal-of-alachlor-diuron-and-isoproturon-in-water-in-a-falling-film-dielectric-barrier-discharge-dbd-reactor-combined-with-adsorption-on-activated-carbon-textile-reaction-mechanisms-and-oxidation-by-products
#12
Patrick Vanraes, Niels Wardenier, Pieter Surmont, Frederic Lynen, Anton Nikiforov, Stijn W H Van Hulle, Christophe Leys, Annemie Bogaerts
A falling film dielectric barrier discharge (DBD) plasma reactor combined with adsorption on activated carbon textile material was optimized to minimize the formation of hazardous oxidation by-products from the treatment of persistent pesticides (alachlor, diuron and isoproturon) in water. The formation of by-products and the reaction mechanism was investigated by HPLC-TOF-MS. The maximum concentration of each by-product was at least two orders of magnitude below the initial pesticide concentration, during the first 10 min of treatment...
May 3, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29751048/predicting-emp-hazard-lessons-from-studies-with-inhaled-fibrous-and-non-fibrous-nano-and-micro-particles
#13
Günter Oberdörster, Uschi Graham
Inhalation exposure to elongated cleavage fragments occurring at mineral and rock mining and crushing operations raises important questions regarding potential health effects given their resemblance to fibers with known adverse health effects like amphibole asbestos. Thus, a major goal for establishing a toxicity profile for elongate mineral particles (EMPs) is to identify and characterize a suspected hazard and characterize a risk by examining together results of hazard and exposure assessment. This will require not only knowledge about biokinetics of inhaled EMPs but also about underlying mechanisms of effects induced by retained EMPs...
May 8, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29750778/correlations-between-mrna-levels-of-centrosomal-protein-55-cep55-and-clinical-features-of-patients-with-lung-cancer
#14
Xue-Ping Ma, Wenping Zhang, Bu-Qiang Wu, Jun Qin
BACKGROUND The aim of this study was to investigate the prognostic relevance of CEP55 in lung cancer (LC). MATERIAL AND METHODS LC microarray profile GSE30219 was obtained from the GEO database. The 2-sample t test was performed to clarify the difference in CEP55 expression between LC and normal lung tissue. The chi-square test and logistic regression analysis were preformed to investigate the relationship between CEP55 expression and the clinical features of LC patients. Log-rank test and Cox proportional hazards regression analysis were conducted to evaluate the disease-free survival (DFS) and overall survival (OS) of LC patients...
May 11, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29748724/decreased-re-operation-rate-for-recurrence-after-defect-closure-in-laparoscopic-ventral-hernia-repair-with-a-permanent-tack-fixated-mesh-a-nationwide-cohort-study
#15
J J Baker, S Öberg, K Andresen, J Rosenberg
PURPOSE: To investigate whether defect closure in laparoscopic ventral hernia repair reduces the re-operation rate for recurrence compared with no defect closure. METHODS: Data were extracted from the Danish Ventral Hernia Database. Adults with an elective laparoscopic ventral hernia repair with tacks used as mesh fixation were included, if their first repair was between the 1st of January 2007 and the 1st of January 2017. Patients with defect closure were compared with no defect closure...
May 10, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
https://www.readbyqxmd.com/read/29748101/results-from-the-study-to-assess-outcomes-after-endovascular-repair-for-multiple-thoracic-aortic-diseases-summit
#16
Nikolaos Tsilimparis, Sebastian Debus, Min Chen, Qing Zhou, Mary-Margaret Seale, Tilo Kölbel
OBJECTIVE: Thoracic endovascular aortic repair (TEVAR) is currently the treatment of choice for most diseases of the descending thoracic aorta. Using data from the Study to Assess Outcomes After Endovascular Repair for Multiple Thoracic Aortic Diseases (SUMMIT) study we investigated the outcomes of TEVAR for different aortic diseases and risk factors associated with the outcomes. METHODS: The SUMMIT study included aggregated data of 521 TEVAR patients from five Cook-sponsored multicenter trials evaluating thoracic endografts of the Zenith platform (William Cook Europe, ApS, Bjaeverskov, Denmark)...
May 7, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29744937/robust-and-reversible-vapoluminescent-organometallic-copper-polymers
#17
Hao Peng, Yumeng Xin, Wei Shen, Zhengtao Deng, Jiuyang Zhang
Emissive organometallic polymers are an important class of functional materials characterized by the combined photoluminescent features of organometallic molecules and the properties of traditional polymers. In this work, the emissive organometallic complex, [CuBr(PPh3 )2 (4-methylpyridine)], is successfully, mechanically ground into a random copolymer built on 4-(diphenylphosphino)styrene (DPVP) and n-butyl acrylate (BA) monomers. The resultant hybrid materials successfully inherit the emissive centers, and are significantly reinforced by the copper complexes as chemical crosslinkers in the polymeric continuum...
May 10, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29743473/increased-expression-of-holliday-junction-recognizing-protein-hjurp-as-an-independent-prognostic-biomarker-in-advanced-stage-serous-ovarian-carcinoma
#18
Lin Li, Xiaoli Li, Qin Meng, Abdul Qadir Khan, Xiaomei Chen
BACKGROUND Advanced-stage serous ovarian carcinoma results in the majority of deaths from ovarian carcinoma. The histone chaperone, Holliday junction-recognizing protein (HJURP), binds with centromere protein-A (CENP-A) and its expression has been shown to be a prognostic biomarker in some cancers. The aim of this study was to investigate the role of HJURP expression in advanced-stage serous ovarian carcinoma. MATERIAL AND METHODS Ninety-eight patients with advanced-stage serous ovarian carcinoma, who had tumor tissue samples available, were studied...
May 10, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29742921/long-term-prognostic-value-of-coronary-computed-tomography-angiography-in-chest-pain-patients
#19
Mårten Sandstedt, Jakob De Geer, Lilian Henriksson, Jan Engvall, Magnus Janzon, Anders Persson, Joakim Alfredsson
Background Coronary computed tomography angiography (CCTA) is increasingly used to detect coronary artery disease (CAD), but long-term follow-up studies are still scarce. Purpose To evaluate the prognostic value of CCTA in patients with suspected CAD. Material and Methods A total of 1205 consecutive CCTA patients with chest pain were classified as normal coronary arteries, non-obstructive CAD, or obstructive CAD. The primary outcome was major adverse cardiac event (MACE), defined as a composite outcome including cardiac death, myocardial infarction, unstable angina pectoris, or late revascularization (after >90 days)...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29738812/dosimetry-of-inhaled-elongate-mineral-particles-in-the-respiratory-tract-the-impact-of-shape-factor
#20
Bahman Asgharian, T Price Owen, Eileen D Kuempel, Annie M Jarabek
Inhalation exposure to some types of fibers (e.g., asbestos) is well known to be associated with respiratory diseases and conditions such as pleural plaques, fibrosis, asbestosis, lung cancer, and mesothelioma. In recent years, attention has expanded to other types of elongate mineral particles (EMPs) that may share similar geometry with asbestos fibers but which may differ in mineralogy. Inhalability, dimensions and orientation, and density are major determinants of the aerodynamic behavior for fibers and other EMPs; and the resultant internal dose is recognized as being the critical link between exposure and pathogenesis...
May 5, 2018: Toxicology and Applied Pharmacology
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