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https://www.readbyqxmd.com/read/28212109/sustainable-exposure-prevention-through-innovative-detection-and-remediation-technologies-from-the-niehs-superfund-research-program
#1
Heather F Henry, William A Suk
Innovative devices and tools for exposure assessment and remediation play an integral role in preventing exposure to hazardous substances. New solutions for detecting and remediating organic, inorganic, and mixtures of contaminants can improve public health as a means of primary prevention. Using a public health prevention model, detection and remediation technologies contribute to primary prevention as tools to identify areas of high risk (e.g. contamination hotspots), to recognize hazards (bioassay tests), and to prevent exposure through contaminant cleanups...
February 17, 2017: Reviews on Environmental Health
https://www.readbyqxmd.com/read/28202383/a-randomized-controlled-trial-of-screening-risk-modification-and-physical-therapy-to-prevent-falls-among-the-elderly-recently-discharged-from-the-emergency-department-to-the-community-the-steps-to-avoid-falls-in-the-elderly-study
#2
David B Matchar, Pamela W Duncan, Christopher T C Lien, Marcus Eng Hock Ong, Mina Lee, Fei Gao, Rita Sim, Kirsten Eom
OBJECTIVE: To evaluate the effectiveness of a multifactorial, tailored program of physical therapy to reduce the occurrence of falls among a heterogeneous group of high-risk elderly Singaporeans recently discharged from the Emergency Department (ED). DESIGN: Randomized controlled trial. SETTING: Communities in Central and East regions in Singapore. PARTICIPANTS: 354 adults aged at least 65 years who were seen at ED for a fall or fall-related injuries and discharged home...
February 12, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28196457/dermal-absorption-of-fumigant-gases-during-hazmat-incident-exposure-scenarios-methyl-bromide-sulfuryl-fluoride-and-chloropicrin
#3
Sharyn Gaskin, Linda Heath, Dino Pisaniello, John W Edwards, Michael Logan, Christina Baxter
Accidental or intentional releases of toxic gases or vapors are the most common occurrence in hazardous material (HAZMAT) incidents that result in human injuries. The most serious hazard from exposure to gases or vapors is via the respiratory system. Dermal uptake, as a secondary route, is still a concern, most acutely for the unprotected public. There is a limited evidence base describing skin absorption of toxic gases and vapors in HAZMAT exposure scenarios, which are relatively brief compared with traditional test periods for skin absorption studies...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/28195425/carbon-nanotubes-disrupt-iron-homeostasis-and-induce-anemia-of-inflammation-through-inflammatory-pathway-as-a-secondary-effect-distant-to-their-portal-of-entry
#4
Juan Ma, Ruibin Li, Yin Liu, Guangbo Qu, Jing Liu, Wenli Guo, Haoyang Song, Xinghong Li, Yajun Liu, Tian Xia, Bing Yan, Sijin Liu
Although numerous toxicological studies have been performed on carbon nanotubes (CNTs), a few studies have investigated their secondary and indirect effects beyond the primary target tissues/organs. Here, a cascade of events are investigated: the initiating event and the subsequent key events necessary for the development of phenotypes, namely CNT-induced pro-inflammatory effects on iron homeostasis and red blood cell formation, which are linked to anemia of inflammation (AI). A panel of CNTs are prepared including pristine multiwall CNTs (P-MWCNTs), aminated MWCNTs (MWCNTs-NH2 ), polyethylene glycol MWCNTs (MWCNTs-PEG), polyethyleneimine MWCNTs (MWCNTs-PEI), and carboxylated MWCNTs (MWCNTs-COOH)...
February 13, 2017: Small
https://www.readbyqxmd.com/read/28195244/health-technology-assessment-introducing-a-vacuum-based-preservation-system-for-biological-materials-in-the-anatomic-pathology-workflow
#5
R Saliceti, E Nicodemo, A Giannini, A Cortese
INTRODUCTION: The objective of this work is to assess the implementation of a newly introduced medical equipment technology for the vacuum-based preservation of biological materials within an Anatomic Pathology service. METHODS: The approach selected for the analysis is the Health Technology Assessment (HTA ), a comprehensive evaluation method based on relevant scientific evidence and designed to support healthcare decision makers in purchasing, replacing or disposing of technologies...
March 2016: Pathologica
https://www.readbyqxmd.com/read/28195202/application-of-pristine-and-doped-sno2-nanoparticles-as-a-matrix-for-agro-hazardous-material-organophosphate-detection
#6
Naushad Khan, Taimur Athar, H Fouad, Ahmad Umar, Z A Ansari, S G Ansari
With an increasing focus on applied research, series of single/composite materials are being investigated for device development to detect several hazardous, dangerous, and toxic molecules. Here, we report a preliminary attempt of an electrochemical sensor fabricated using pristine Ni and Cr-doped nano tin oxide material (SnO2) as a tool to detect agro-hazardous material, i.e. Organophosphate (OP, chlorpyrifos). The nanomaterial was synthesized using the solution method. Nickel and chromium were used as dopant during synthesis...
February 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28178228/imaging-evaluation-of-the-safe-region-for-distal-locking-screw-of-proximal-femoral-nail-anti-rotation-in-patients-with-proximal-femoral-fracture
#7
Jinpeng Gong, Pengcheng Liu, Ming Cai
BACKGROUND Proximal femoral nail anti-rotation (PFNA) is a standard femoral intertrochanteric fracture operation. Iatrogenic vascular injury, although uncommon, is a reported complication of PFNA surgery as well as a complication of hip fracture surgery. This study aimed to compare the safety and best use of the distal locking screw in 170 mm PFNA and 240 mm PFNA devices, and to determine the safe region for placement of the distal locking screw in PFNA surgery. MATERIAL AND METHODS A retrospective analysis of 100 patients with 170 mm PFNA and 80 patients with 240 mm PFNA were retrospectively analyzed...
February 8, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28177603/pro-inflammatory-and-pro-fibrogenic-effects-of-ionic-and-particulate-arsenide-and-indium-containing-semiconductor-materials-in-the-murine-lung
#8
Wen Jiang, Xiang Wang, Olivia J Osborne, Yingjie Du, Chong Hyun Chang, Yu-Pei Liao, Bingbing Sun, Jinhong Jiang, Zhaoxia Ji, Ruibin Li, Xiangsheng Liu, Jianqin Lu, Sijie Lin, Huan Meng, Tian Xia, André E Nel
We have recently shown that the toxicological potential of GaAs and InAs particulates in cells is size- and dissolution-dependent, tending to be more pronounced for nano- vs micron-sized particles. Whether the size-dependent dissolution and shedding of ionic III-V materials also apply to pulmonary exposure is unclear. While it has been demonstrated that micron-sized III-V particles, such as GaAs and InAs, are capable of inducing hazardous pulmonary effects in an occupational setting as well as in animal studies, the effect of submicron particles (e...
February 8, 2017: ACS Nano
https://www.readbyqxmd.com/read/28168667/literature-review-of-q-sar-modelling-of-nanomaterial-toxicity
#9
Ceyda Oksel, Cai Y Ma, Jing J Liu, Terry Wilkins, Xue Z Wang
Despite the clear benefits that nanotechnology can bring to various sectors of industry, there are serious concerns about the potential health risks associated with engineered nanomaterials (ENMs), intensified by the limited understanding of what makes ENMs toxic and how to make them safe. As the use of ENMs for commercial purposes and the number of workers/end-users being exposed to these materials on a daily basis increases, the need for assessing the potential adverse effects of multifarious ENMs in a time- and cost-effective manner becomes more apparent...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28168196/preoperative-gamma-glutamyltransferase-is-associated-with-cancer-specific-survival-and-recurrence-free-survival-of-nonmetastatic-renal-cell-carcinoma-with-venous-tumor-thrombus
#10
Cheng Luo, Ben Xu, Yu Fan, Wei Yu, Qian Zhang, Jie Jin
Introduction. To evaluate the prognostic significance of preoperative gamma-glutamyltransferase (GGT) on the subgroup of nonmetastatic renal cell carcinoma (RCC) with venous tumor thrombus. Materials and Methods. We retrospectively reviewed the institutional database and collected the medical data of 156 patients with nonmetastatic RCC with venous tumor thrombus between March 2004 and December 2014. Kaplan-Meier and Cox regression analyses were applied to determine the prognostic factors for cancer-specific survival (CSS) and recurrence-free survival (RFS)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28167959/chemotherapy-plus-cetuximab-versus-chemotherapy-alone-for-patients-with-kras-wild-type-unresectable-liver-confined-metastases-colorectal-cancer-an-updated-meta-analysis-of-rcts
#11
REVIEW
W Lv, G Q Zhang, A Jiao, B C Zhao, Y Shi, B M Chen, J L Zhang
Purpose. Our study analyses clinical trials and evaluates the efficacy of adding cetuximab in systematic chemotherapy for unresectable colorectal cancer liver-confined metastases patients. Materials and Methods. Search EMBASE, PubMed, and the Cochrane Central Register of Controlled Trials for RCTs comparing chemotherapy plus cetuximab with chemotherapy alone for KRAS wild type patients with colorectal cancer liver metastases (CRLMs). We calculated the relative risks (RRs) with 95% confidence interval and performed meta-analysis of hazard ratios (HRs) for the R0 resection rate, the overall response rate (ORR), the progression-free survival (PFS) and overall survival (OS)...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28161204/chemical-alternatives-assessment-of-different-flame-retardants-a-case-study-including-multi-walled-carbon-nanotubes-as-synergist
#12
REVIEW
Karin Aschberger, Ivana Campia, Laia Quiros Pesudo, Anita Radovnikovic, Vittorio Reina
Flame retardants (FRs) are a diverse group of chemicals used as additives in a wide range of products to inhibit, suppress, or delay ignition and to prevent the spread of fire. Halogenated FRs (HFRs) are widely used because of their low impact on other material properties and the low loading levels necessary to meet the required flame retardancy. Health and environmental hazards associated with some halogenated FRs have driven research for identifying safer alternatives. A variety of halogen-free FRs are available on the market, including organic (phosphorus and nitrogen based chemicals) and inorganic (metals) materials...
February 1, 2017: Environment International
https://www.readbyqxmd.com/read/28160717/a-new-approach-to-characterize-very-low-level-radioactive-waste-produced-at-hadron-accelerators
#13
Biagio Zaffora, Matteo Magistris, Jean-Pierre Chevalier, Catherine Luccioni, Gilbert Saporta, Luisa Ulrici
Radioactive waste is produced as a consequence of preventive and corrective maintenance during the operation of high-energy particle accelerators or associated dismantling campaigns. Their radiological characterization must be performed to ensure an appropriate disposal in the disposal facilities. The radiological characterization of waste includes the establishment of the list of produced radionuclides, called "radionuclide inventory", and the estimation of their activity. The present paper describes the process adopted at CERN to characterize very-low-level radioactive waste with a focus on activated metals...
January 26, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28159447/medical-device-guidebook-a-browser-information-resource-for-medical-device-users
#14
Douglas M Clarkson
A web based information resource - the 'Medical Device Guidebook' - for the enabling of safe use of medical devices is described. Medical devices are described within a 'catalogue' of specific models and information on a specific model is provided within a consistent set of information 'keys'. These include 'user manuals', 'points of caution', 'clinical use framework', 'training/assessment material', 'frequently asked questions', 'authorised user comments' and 'consumables'. The system allows identification of known risk/hazards associated with specific devices, triggered, for example, by national alerts or locally raised safety observations...
January 31, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28159104/how-cutting-edge-technologies-impact-the-design-of-electrochemical-bio-sensors-for-environmental-analysis-a-review
#15
REVIEW
Fabiana Arduini, Stefano Cinti, Viviana Scognamiglio, Danila Moscone, Giuseppe Palleschi
Through the years, scientists have developed cutting-edge technologies to make (bio)sensors more convenient for environmental analytical purposes. Technological advancements in the fields of material science, rational design, microfluidics, and sensor printing, have radically shaped biosensor technology, which is even more evident in the continuous development of sensing systems for the monitoring of hazardous chemicals. These efforts will be crucial in solving some of the problems constraining biosensors to reach real environmental applications, such as continuous analyses in field by means of multi-analyte portable devices...
March 22, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28157878/multiplex-coherent-anti-stokes-raman-scattering-spectroscopy-for-trace-chemical-detection
#16
Sherrie B Pilkington, Stephen D Roberson, Paul M Pellegrino
Trace chemical detection is a particularly challenging problem of significant Army interest. Optical diagnostic techniques offer rapid, accurate, sensitive, and highly selective detection of hazardous materials in a variety of systems. Multiplex coherent anti-stokes Raman scattering (MCARS) spectroscopy generates a complete Raman spectrum from the material of interest using a combination of a supercontinuum pulse, which drives multiple molecular vibrations simultaneously, and a narrowband probe pulse. In this study, we demonstrated the ability of MCARS to detect trace amounts of both explosive materials and chemical warfare agent simulants with limits of detection below 0...
January 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28157473/occupational-exposure-and-idiopathic-pulmonary-fibrosis-a-multicentre-case-control-study-in-korea
#17
J-W Koo, J-P Myong, H-K Yoon, C K Rhee, Y Kim, J S Kim, B S Jo, Y Cho, J Byun, M Choi, H-R Kim, E-A Kim
SETTING: Multicentred hospital-based cases and control subjects in Korea. OBJECTIVE: To evaluate the association between idiopathic pulmonary fibrosis (IPF) and hazardous materials to which people are occupationally exposed. DESIGN: A multicentre, hospital-based, matched case-control study was performed. The ratio of IPF cases to controls was 1:1 (n = 78 in each group). IPF cases and controls were matched in terms of age group, sex and place of residence...
January 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28156200/diagnostic-and-prognostic-value-of-long-axis-strain-and-myocardial-contraction-fraction-using-standard-cardiovascular-mr-imaging-in-patients-with-nonischemic-dilated-cardiomyopathies
#18
Nisha Arenja, Johannes H Riffel, Thomas Fritz, Florian André, Fabian Aus dem Siepen, Matthias Mueller-Hennessen, Evangelos Giannitsis, Hugo A Katus, Matthias G Friedrich, Sebastian J Buss
Purpose To assess the utility of established functional markers versus two additional functional markers derived from standard cardiovascular magnetic resonance (MR) images for their incremental diagnostic and prognostic information in patients with nonischemic dilated cardiomyopathy (NIDCM). Materials and Methods Approval was obtained from the local ethics committee. MR images from 453 patients with NIDCM and 150 healthy control subjects were included between 2005 and 2013 and were analyzed retrospectively...
February 2, 2017: Radiology
https://www.readbyqxmd.com/read/28152053/evaluation-of-absorbent-materials-for-use-as-ad-hoc-dry-decontaminants-during-mass-casualty-incidents-as-part-of-the-uk-s-initial-operational-response-ior
#19
Nick Kassouf, Sara Syed, Joanne Larner, Richard Amlôt, Robert P Chilcott
The UK's Initial Operational Response (IOR) is a revised process for the medical management of mass casualties potentially contaminated with hazardous materials. A critical element of the IOR is the introduction of immediate, on-scene disrobing and decontamination of casualties to limit the adverse health effects of exposure. Ad hoc cleansing of the skin with dry absorbent materials has previously been identified as a potential means of facilitating emergency decontamination. The purpose of this study was to evaluate the in vitro oil and water absorbency of a range of materials commonly found in the domestic and clinical environments and to determine the effectiveness of a small, but representative selection of such materials in skin decontamination, using an established ex vivo model...
2017: PloS One
https://www.readbyqxmd.com/read/28150216/neutron-activatable-nanoparticles-for-intraperitoneal-radiation-therapy
#20
Derek Hargrove, Xiuling Lu
Intraperitoneal internal radiation therapy is a cancer treatment option that is employed in situations where surgical resection, systemic chemotherapy, and external beam radiotherapy are not amenable for patients. However, exposure of noncancerous tissues to radiation continues to be a hindrance to safe and effective treatment of patients. In addition, reducing prolonged radiation exposure of personnel during preparation of internal radiation therapy agents makes their manufacture complicated and hazardous...
2017: Methods in Molecular Biology
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