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https://www.readbyqxmd.com/read/28476872/integrative-analysis-identifies-a-novel-axl-pi3-kinase-pd-l1-signaling-axis-associated-with-radiation-resistance-in-head-and-neck-cancer
#1
Heath D Skinner, Uma Giri, Liang P Yang, Manish Kumar, Ying Liu, Michael D Story, Curtis R Pickering, Lauren A Byers, Michelle D Williams, Jing Wang, Li Shen, Suk Y Yoo, You Hong Fan, David P Molkentine, Beth M Beadle, Raymond E Meyn, Jeffrey N Myers, John V Heymach
Purpose: The primary cause of death due to head and neck squamous cell carcinoma (HNSCC) is local treatment failure. The goal of this study was to examine this phenomenon using an unbiased approach.Experimental Design: We utilized human papilloma virus (HPV)-negative cell lines rendered radiation-resistant (RR) via repeated exposure to radiation, a panel of HPV-negative HNSCC cell lines and three cohorts of HPV-negative HNSCC tumors (n = 68, 97, and 114) from patients treated with radiotherapy and subjected to genomic, transcriptomic, and proteomic analysis...
May 5, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28469535/association-between-deep-sedation-from-continuous-intravenous-sedatives-and-extubation-failures-in-mechanically-ventilated-patients-in-the-pediatric-intensive-care-unit
#2
Jennifer M Schultheis, Travis S Heath, David A Turner
OBJECTIVE: The primary objective of this study was to determine whether an association exists between deep sedation from continuous infusion sedatives and extubation failures in mechanically ventilated children. Secondary outcomes evaluated risk factors associated with deep sedation. METHODS: This was a retrospective cohort study conducted between January 1, 2009, and October 31, 2012, in the pediatric intensive care unit (PICU) at Duke Children's Hospital. Patients were included in the study if they had been admitted to the PICU, had been mechanically ventilated for ≥48 hours, and had received at least one continuous infusion benzodiazepine and/or opioid infusion for ≥24 hours...
March 2017: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
https://www.readbyqxmd.com/read/28468708/fading-away-in-plain-sight
#3
Shirley A Lucier
The failure of health care professionals and providers to recognize and discuss end-of-life care continues to resonate across our heath care continuum. The value of the patient-clinician interaction is paramount in advocating for and establishing effective communication and care. A meaningful nurse-patient relationship is a key component to facilitate discussion of patient and family choices in how care can be managed throughout the dying process. This article describes how, using Virginia Henderson's nursing model of patientcentered care, a holistic and palliative approach to end-of-life care was successfully supported in the home...
May 1, 2017: Creative Nursing
https://www.readbyqxmd.com/read/28431202/pharmacological-interventions-for-acute-pancreatitis
#4
REVIEW
Elisabetta Moggia, Rahul Koti, Ajay P Belgaumkar, Federico Fazio, Stephen P Pereira, Brian R Davidson, Kurinchi Selvan Gurusamy
BACKGROUND: In people with acute pancreatitis, it is unclear what the role should be for medical treatment as an addition to supportive care such as fluid and electrolyte balance and organ support in people with organ failure. OBJECTIVES: To assess the effects of different pharmacological interventions in people with acute pancreatitis. SEARCH METHODS: We searched the Cochrane Central Register of Controlled Trials (CENTRAL, 2016, Issue 9), MEDLINE, Embase, Science Citation Index Expanded, and trial registers to October 2016 to identify randomised controlled trials (RCTs)...
April 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28403233/cost-effectiveness-of-cetuximab-and-panitumumab-for-chemotherapy-refractory-metastatic-colorectal-cancer
#5
Adriana Camargo Carvalho, Frederico Leal, Andre Deeke Sasse
BACKGROUND: Cetuximab and panitumumab are monoclonal antibodies targeting the epidermal growth factor receptor. Both drugs are active against RAS wild type metastatic colorectal cancer after chemotherapy failure, with similar efficacy and toxicity profiles. However, their cost and limited survival benefits may compromise incorporation in the Brazilian public healthcare system, the Unified Heath System (Sistema Único de Saúde) (SUS). METHODS: A cost-effectiveness analysis was conducted using a Markov model from the Brazilian Public health perspective and a lifetime horizon in patients with RAS -wt mCRC...
2017: PloS One
https://www.readbyqxmd.com/read/28350243/fitts-theorem-and-movement-time-dissociation-for-amplitude-and-width-manipulations-replying-to-hoffmann
#6
Matthew Heath, Luc Tremblay, Digby Elliott
The commentary by Errol Hoffmann asserts that previous work by our group provides the spurious conclusion that amplitude and width manipulations to a movement environment elicit dissociable relations between movement time (MT) and P. M. Fitts' (1954) index of difficulty (ID). Hoffmann concludes that any such dissociation is the result of actions evoked entirely as ballistic. In this reply, we demonstrate that Hoffmann's commentary is a clear misrepresentation of the study goals and conclusions stated by our group...
March 28, 2017: Journal of Motor Behavior
https://www.readbyqxmd.com/read/28343415/is-therapeutic-hypothermia-for-acute-respiratory-distress-syndrome-the-future
#7
Adam J Hayek, Heath D White, Shekhar Ghamande, Christopher Spradley, Alejandro C Arroliga
INTRODUCTION: Severe acute respiratory distress syndrome (ARDS) has a high mortality, and there is limited knowledge about management of severe ARDS refractory to standard therapy. Early evidence suggests that therapeutic hypothermia (TH) could be a viable treatment for acute respiratory failure. We present 2 cases where TH was successfully used to manage refractory ARDS on extracorporeal membrane oxygenation (ECMO) and a review of the literature around TH and acute respiratory failure...
January 1, 2017: Journal of Intensive Care Medicine
https://www.readbyqxmd.com/read/28259545/selective-nonoperative-management-of-abdominal-gunshot-wounds-from-heresy-to-adoption-a-multicenter-study-of-the-research-consortium-of-new-england-centers-for-trauma-reconect
#8
Thomas Peponis, George Kasotakis, Jielin Yu, Reginald Alouidor, Barbara Burkott, Adrian A Maung, Dirk C Johnson, Noelle Saillant, Heath Walden, Ali Salim, Elizabeth Bryant, Jon D Dorfman, Eric N Klein, Ronen Elefant, Maryam B Tabrizi, Nikolay Bugaev, Sandra S Arabian, George C Velmahos
BACKGROUND: Selective nonoperative management (SNOM) of abdominal gunshot wounds is being practiced in certain trauma centers, but its broader acceptance in the surgical community is unknown. We hypothesized that SNOM has been adopted in New England as an acceptable method of abdominal gunshot wound management. STUDY DESIGN: We reviewed the medical records of abdominal gunshot wound patients admitted from January 1996 to June 2015, in 10 New England Level I and II trauma centers...
March 1, 2017: Journal of the American College of Surgeons
https://www.readbyqxmd.com/read/28226332/responsible-safe-and-effective-prescription-of-opioids-for-chronic-non-cancer-pain-american-society-of-interventional-pain-physicians-asipp-guidelines
#9
Laxmaiah Manchikanti, Adam M Kaye, Nebojsa Nick Knezevic, Heath McAnally, Konstantin Slavin, Andrea M Trescot, Susan Blank, Vidyasagar Pampati, Salahadin Abdi, Jay S Grider, Alan D Kaye, Kavita N Manchikanti, Harold Cordner, Christopher G Gharibo, Michael E Harned, Sheri L Albers, Sairam Atluri, Steve M Aydin, Sanjay Bakshi, Robert L Barkin, Ramsin M Benyamin, Mark V Boswell, Ricardo M Buenaventura, Aaron K Calodney, David L Cedeno, Sukdeb Datta, Timothy R Deer, Bert Fellows, Vincent Galan, Vahid Grami, Hans Hansen, Standiford Helm Ii, Rafael Justiz, Dhanalakshmi Koyyalagunta, Yogesh Malla, Annu Navani, Kent H Nouri, Ramarao Pasupuleti, Nalini Sehgal, Sanford M Silverman, Thomas T Simopoulos, Vijay Singh, Daneshvari R Solanki, Peter S Staats, Ricardo Vallejo, Bradley W Wargo, Arthur Watanabe, Joshua A Hirsch
BACKGROUND: Opioid use, abuse, and adverse consequences, including death, have escalated at an alarming rate since the 1990s. In an attempt to control opioid abuse, numerous regulations and guidelines for responsible opioid prescribing have been developed by various organizations. However, the US opioid epidemic is continuing and drug dose deaths tripled during 1999 to 2015. Recent data show a continuing increase in deaths due to natural and semisynthetic opioids, a decline in methadone deaths, and an explosive increase in the rates of deaths involving other opioids, specifically heroin and illicit synthetic fentanyl...
February 2017: Pain Physician
https://www.readbyqxmd.com/read/28089497/biomechanical-comparison-of-standard-and-linked-single-row-rotator-cuff-repairs-in-a-human-cadaver-model
#10
Adam F Meisel, Heath B Henninger, F Alan Barber, Mark H Getelman
PURPOSE: The purpose of this study was to evaluate the time zero cyclic and failure loading properties of a linked single-row rotator cuff repair compared with a standard simple suture single-row repair using triple-loaded suture anchors. METHODS: Eighteen human cadaveric shoulders from 9 matched pairs were dissected, and full-thickness supraspinatus tears were created. The tendon cross-sectional area was recorded. In each pair, one side was repaired with a linked single-row construct and the other with a simple suture single-row construct, both using 2 triple-loaded suture anchors...
January 12, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28006086/recurrent-oral-cavity-cancer-patterns-of-failure-after-salvage-multimodality-therapy
#11
Sean R Quinlan-Davidson, William H Morrison, Jeffrey N Myers, Gary B Gunn, William N William, Beth M Beadle, Heath D Skinner, Ann M Gillenwater, Steven J Frank, Jack Phan, Faye M Johnson, Clifton D Fuller, Mark E Zafereo, David I Rosenthal, Adam S Garden
BACKGROUND: We focused on a cohort of radiation naïve patients who had recurrent oral cavity cancer (recurrent OCC) to assess their outcomes with salvage multimodal therapy. METHODS: A retrospective single institutional study was performed of patients with recurrent OCC. Disease recurrence and survival outcomes were assessed. RESULTS: Seventy-eight patients were analyzed. All patients had salvage surgery and intensity-modulated radiotherapy (IMRT) and 74% had chemotherapy...
December 22, 2016: Head & Neck
https://www.readbyqxmd.com/read/28005110/biomechanics-of-polyhydroxyalkanoate-mesh-augmented-single-row-rotator-cuff-repairs
#12
Robert Z Tashjian, Christopher W Kolz, Thomas Suter, Heath B Henninger
Polyhydroxyalkanoate (PHA) mesh is a bioresorbable scaffold used to reinforce the suture-tendon interface in rotator cuff repairs (RCRs). We conducted a study of cyclic and ultimate failure properties of PHA mesh-augmented single-row RCRs and nonaugmented RCRs. Eight pairs of fresh-frozen cadaver humeri (6 male, 2 female) were tested. Mean (SD) age was 61 (9) years. The supraspinatus tendon was resected and reattached in a single-row configuration using 2 triple-loaded suture anchors and 6 simple stitches. The opposite humerus underwent RCR augmented with 2 strips of 13-mm × 23-mm PHA mesh...
November 2016: American Journal of Orthopedics
https://www.readbyqxmd.com/read/27886864/an-autopsy-case-of-refractory-pulmonary-hypertension-with-sarcoidosis
#13
Hiroki Ota, Keishi Sugino, Toshimasa Uekusa, Tamiko Takemura, Sakae Homma
A 63-year-old man with sarcoidosis-associated pulmonary hypertension (SAPH) died suddenly of decompensated right heart failure. At autopsy, microscopy showed subpleural and interlobular fibrosis in both upper lobes, with marked broncho-bronchiolectasis, as well as bronchovascular bundle fibrosis and fibrotic organization in alveolar lumens, which are consistent with pulmonary sarcoidosis. Intimal fibrosis and medial hypertrophy were noted in the proximal elastic to distal muscular pulmonary arteries (Heath-Edwards, grades II-III) within intensive fibrotic lesions...
November 2016: Respiratory Investigation
https://www.readbyqxmd.com/read/27878076/nonmotorized-recreation-and-motorized-recreation-in-shrub-steppe-habitats-affects-behavior-and-reproduction-of-golden-eagles-aquila-chrysaetos
#14
Robert J Spaul, Julie A Heath
Different forms of outdoor recreation have different spatiotemporal activity patterns that may have interactive or cumulative effects on wildlife through human disturbance, physical habitat change, or both. In western North America, shrub-steppe habitats near urban areas are popular sites for motorized recreation and nonmotorized recreation and can provide important habitat for protected species, including golden eagles. Our objective was to determine whether recreation use (i.e., number of recreationists) or recreation features (e...
November 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/27863248/%C3%AE-glucan-reverses-the-epigenetic-state-of-lps-induced-immunological-tolerance
#15
Boris Novakovic, Ehsan Habibi, Shuang-Yin Wang, Rob J W Arts, Robab Davar, Wout Megchelenbrink, Bowon Kim, Tatyana Kuznetsova, Matthijs Kox, Jelle Zwaag, Filomena Matarese, Simon J van Heeringen, Eva M Janssen-Megens, Nilofar Sharifi, Cheng Wang, Farid Keramati, Vivien Schoonenberg, Paul Flicek, Laura Clarke, Peter Pickkers, Simon Heath, Ivo Gut, Mihai G Netea, Joost H A Martens, Colin Logie, Hendrik G Stunnenberg
Innate immune memory is the phenomenon whereby innate immune cells such as monocytes or macrophages undergo functional reprogramming after exposure to microbial components such as lipopolysaccharide (LPS). We apply an integrated epigenomic approach to characterize the molecular events involved in LPS-induced tolerance in a time-dependent manner. Mechanistically, LPS-treated monocytes fail to accumulate active histone marks at promoter and enhancers of genes in the lipid metabolism and phagocytic pathways. Transcriptional inactivity in response to a second LPS exposure in tolerized macrophages is accompanied by failure to deposit active histone marks at promoters of tolerized genes...
November 17, 2016: Cell
https://www.readbyqxmd.com/read/27860831/the-integrative-physiology-of-insect-chill-tolerance
#16
Johannes Overgaard, Heath A MacMillan
Cold tolerance is important in defining the distribution of insects. Here, we review the principal physiological mechanisms underlying homeostatic failure during cold exposure in this diverse group of ectotherms. When insects are cooled sufficiently, they suffer an initial loss of neuromuscular function (chill coma) that is caused by decreased membrane potential and reduced excitability of the neuromuscular system. For chill-susceptible insects, chronic or severe chilling causes a disruption of ion and water homeostasis across membranes and epithelia that exacerbate the initial effects of chilling on membrane potential and cellular function, and these perturbations are tightly associated with the development of chill injury and mortality...
February 10, 2017: Annual Review of Physiology
https://www.readbyqxmd.com/read/27821509/approach-to-the-diagnosis-and-treatment-of-high-grade-b-cell-lymphomas-with-myc-and-bcl2-and-or-bcl6-rearrangements
#17
REVIEW
Pierre Sesques, Nathalie A Johnson
High-grade B-cell lymphomas (HGBLs) with MYC and BCL2 and/or BCL6 rearrangements, so-called "double-hit" lymphomas (HGBL-DH), are aggressive lymphomas that form a separate provisional entity in the 2016 revised World Health Organization Classification of Lymphoid Tumors. Fluorescence in situ hybridization (FISH) will be required to identify HGBL-DH and will reclassify a subset of diffuse large B-cell lymphomas (DLBCLs) and HGBLs with features intermediate between DLBCL and Burkitt lymphoma into this new category...
January 19, 2017: Blood
https://www.readbyqxmd.com/read/27599938/streptococcus-iniae-cpsg-alters-capsular-carbohydrate-composition-and-is-a-cause-of-serotype-switching-in-vaccinated-fish
#18
Candice Heath, Christine M Gillen, Panagiotis Chrysanthopoulos, Mark J Walker, Andrew C Barnes
Streptococcus iniae causes septicaemia and meningitis in marine and freshwater fish wherever they are farmed in warm-temperate and tropical regions. Although serotype specific, vaccination with bacterins (killed bacterial cultures) is largely successful and vaccine failure occurs only occasionally through emergence of new capsular serotypes. Previously we showed that mutations in vaccine escapes are restricted to a limited repertoire of genes within the 20-gene capsular polysaccharide (cps) operon. cpsG, a putative UDP-galactose 4-epimerase, has three sequence types based on the insertion or deletion of the three amino acids leucine, serine and lysine in the substrate binding site of the protein...
September 25, 2016: Veterinary Microbiology
https://www.readbyqxmd.com/read/27575796/improving-heart-failure-outcomes-the-role-of-the-clinical-nurse-specialist
#19
Jennifer Coen, Kimberly Curry
This article identifies and explains barriers to optimal outcomes of heart failure and the role of the clinical nurse specialist in overcoming these obstacles, improving patient outcomes and quality of life. In recent years, advances in heart failure management have increased survival rates, and as a result, the number of patients requiring services to manage disease progression and the complex array of symptoms associated with end-stage heart disease. Management of the heart failure patient is dependent on the severity of the disease and wide range of available treatment regimens...
October 2016: Critical Care Nursing Quarterly
https://www.readbyqxmd.com/read/27553752/pharmacokinetics-and-dosing-of-anti-infective-drugs-in-patients-on-extracorporeal-membrane-oxygenation-a-review-of-the-current-literature
#20
REVIEW
Jennifer Sherwin, Travis Heath, Kevin Watt
PURPOSE: Extracorporeal membrane oxygenation (ECMO) is a cardiopulmonary bypass device that is used to temporarily support the most critically ill of patients with respiratory and/or cardiac failure. Infection and its sequelae may be an indication for ECMO or infections may be acquired while on ECMO and are associated with a mortality >50%. Effective therapy requires optimal dosing. However, optimal dosing can be different in patients on ECMO because the ECMO circuit can alter drug pharmacokinetics...
September 2016: Clinical Therapeutics
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