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heath failure

Candice Heath, Christine M Gillen, Panagiotis Chrysanthopoulos, Mark J Walker, Andrew C Barnes
Streptococcus iniae causes septicaemia and meningitis in marine and freshwater fish wherever they are farmed in warm-temperate and tropical regions. Although serotype specific, vaccination with bacterins (killed bacterial cultures) is largely successful and vaccine failure occurs only occasionally through emergence of new capsular serotypes. Previously we showed that mutations in vaccine escapes are restricted to a limited repertoire of genes within the 20-gene capsular polysaccharide (cps) operon. cpsG, a putative UDP-galactose 4-epimerase, has three sequence types based on the insertion or deletion of the three amino acids leucine, serine and lysine in the substrate binding site of the protein...
September 25, 2016: Veterinary Microbiology
Jennifer Coen, Kimberly Curry
This article identifies and explains barriers to optimal outcomes of heart failure and the role of the clinical nurse specialist in overcoming these obstacles, improving patient outcomes and quality of life. In recent years, advances in heart failure management have increased survival rates, and as a result, the number of patients requiring services to manage disease progression and the complex array of symptoms associated with end-stage heart disease. Management of the heart failure patient is dependent on the severity of the disease and wide range of available treatment regimens...
October 2016: Critical Care Nursing Quarterly
Jennifer Sherwin, Travis Heath, Kevin Watt
PURPOSE: Extracorporeal membrane oxygenation (ECMO) is a cardiopulmonary bypass device that is used to temporarily support the most critically ill of patients with respiratory and/or cardiac failure. Infection and its sequelae may be an indication for ECMO or infections may be acquired while on ECMO and are associated with a mortality >50%. Effective therapy requires optimal dosing. However, optimal dosing can be different in patients on ECMO because the ECMO circuit can alter drug pharmacokinetics...
September 2016: Clinical Therapeutics
Akika Ando, Jaclyn Kagihara, Heath Chung, Dennis Thomas Bolger
A 24-year-old otherwise healthy man presented with a 3-week history of malaise, headache, fever and rigors after he was treated with oral clindamycin for left parotitis and Gemella haemolysans bacteraemia. He developed G. haemolysans infective endocarditis, septic emboli and heart failure due to progressive bivalvular disease. He underwent urgent mechanical aortic valve replacement and mitral valve repair, which required venovenous extracorporeal membrane oxygenation, to support severe respiratory failure. This is the first documented case of G...
2016: BMJ Case Reports
Sarah Hull, Aeesha N J Malik, Gavin Arno, Donna S Mackay, Vincent Plagnol, Michel Michaelides, Sahar Mansour, Assunta Albanese, Katrina Tatton Brown, Graham E Holder, Andrew R Webster, Paul T Heath, Anthony T Moore
IMPORTANCE: A multiorgan syndromic disorder characterized by sideroblastic anemia, immunodeficiency, periodic fever, and developmental delay with an uncharacterized retinal dystrophy is caused by TRNT1. This report of a family with a homozygous mutation in TRNT1 expands the ocular phenotype to include cataract and inner retinal dysfunction and details a mild systemic phenotype. OBSERVATIONS: A consanguineous family with 3 affected children was investigated. Key clinical features comprised hypogammaglobulinemia, short stature with microcephaly, cataract, and inner retinal dysfunction without sideroblastic anemia or developmental delay...
September 1, 2016: JAMA Ophthalmology
Yves Gorin
Both acute kidney injury (AKI) and chronic kidney disease (CKD) are major causes of renal failure in humans and are associated with high incidences of morbidity and mortality rates. AKI and CKD are closely interconnected, and fueled by the obesity and diabetes epidemic, their prevalence is alarmingly increasing to the point that it currently represents a major heath issue worldwide. The kidney is an organ that is particularly sensitive to redox imbalance, resulting in excessive production of reactive oxygen species...
August 1, 2016: Antioxidants & Redox Signaling
Awalpreet S Chadha, Heath D Skinner, Jillian R Gunther, Mark F Munsell, Prajnan Das, Bruce D Minsky, Marc E Delclos, Deyali Chatterjee, Huamin Wang, Marilyn Clemons, Geena George, Pankaj K Singh, Matthew H Katz, Jason B Fleming, Milind M Javle, Robert A Wolff, Gauri R Varadhachary, Christopher H Crane, Sunil Krishnan
PURPOSE: To determine the safety, tolerability and maximum tolerated dose (MTD) of addition of erlotinib to bevacizumab and capecitabine-based definitive chemoradiation (CRT) in unresectable pancreatic cancer. METHODS: Seventeen patients with CT-staged, biopsy-proven unresectable pancreatic cancer were enrolled between 3/2008 and 10/2010. Prior chemotherapy was permitted. Two patients each were enrolled at dose levels (DLs) 1-4 and 9 patients at DL 5. All patients received 50...
2016: PloS One
Jimena Barraza-García, Carlos I Rivera-Pedroza, Alberta Belinchón, Carlota Fernández-Camblor, Blanca Valenciano-Fuente, Pablo Lapunzina, Karen E Heath
Schimke immunoosseous dysplasia (SIOD) is an autosomal recessive disease characterized by skeletal dysplasia, focal segmental glomerulosclerosis, renal failure and immunodeficiency. In this work, we report the molecular studies undertaken in a severely affected SIOD patient that died at six years old due to nephropathy. The patient was screened for mutations using a targeted skeletal dysplasias panel. A homozygous novel missense mutation was identified, c.1615C > G (p.[Leu539Val]) that was predicted as mildly pathogenic by in silico pathogenicity prediction tools...
August 2016: European Journal of Medical Genetics
Anthony Montanez, Christopher A Makarewich, Robert T Burks, Heath B Henninger
BACKGROUND: Despite advances in surgical technique, rotator cuff repair retears continue to occur at rates of 10%, 22%, and 57% for small, medium, and large tears, respectively. A common mode of failure in transosseous-equivalent rotator cuff repairs is tissue pullout of the medial mattress stitch. While the medial mattress stitch has been studied extensively, no studies have evaluated a vertical mattress pattern placed near the musculotendinous junction in comparison with a horizontal mattress pattern...
September 2016: American Journal of Sports Medicine
Rushna Ali, Jason M Schwalb, David R Nerenz, Heath J Antoine, Ilan Rubinfeld
OBJECTIVE Limited tools exist to stratify perioperative risk in patients undergoing spinal procedures. The modified frailty index (mFI) based on the Canadian Study of Health and Aging Frailty Index (CSHA-FI), constructed from standard demographic variables, has been applied to various other surgical populations for risk stratification. The authors hypothesized that it would be predictive of postoperative morbidity and mortality in patients undergoing spine surgery. METHODS The 2006-2010 National Surgical Quality Improvement Program (NSQIP) data set was accessed for patients undergoing spine surgeries based on Current Procedural Terminology (CPT) codes...
May 6, 2016: Journal of Neurosurgery. Spine
Manuela Arbune, Costinela Valerica Georgescu, Doina Carina Voinescu
Non-Hodgkin's lymphoma (NHL) is an acquired immunodeficiency syndrome (AIDS)-indicative disease. Nowadays, NHL is rarely reported in Europe as indicative disease for human immunodeficiency virus (HIV) testing. We present the case of a 22-year-old Romanian male patient without past medical history, except the swelling of a submental lymph node 11 months ago. The excised node was histologically examined but the patient neglected to take his result. He was admitted for fever, asthenia, and weight loss over 10% of his weight, and night sweats in the last four months...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
G Brandon Gunn, Pierre Blanchard, Adam S Garden, X Ronald Zhu, C David Fuller, Abdallah S Mohamed, William H Morrison, Jack Phan, Beth M Beadle, Heath D Skinner, Erich M Sturgis, Merrill S Kies, Kate A Hutcheson, David I Rosenthal, Radhe Mohan, Michael T Gillin, Steven J Frank
PURPOSE: A single-institution prospective study was conducted to assess disease control and toxicity of proton therapy for patients with head and neck cancer. METHODS AND MATERIALS: Disease control, toxicity, functional outcomes, and patterns of failure for the initial cohort of patients with oropharyngeal squamous carcinoma (OPC) treated with intensity modulated proton therapy (IMPT) were prospectively collected in 2 registry studies at a single institution. Locoregional failures were analyzed by using deformable image registration...
May 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Kosei Nakajima, Dong Hyo Kho, Takashi Yanagawa, Melissa Zimel, Elisabeth Heath, Victor Hogan, Avraham Raz
The skeleton is frequently a secondary growth site of disseminated cancers, often leading to painful and devastating clinical outcomes. Metastatic cancer distorts bone marrow homeostasis through tumor-derived factors, which shapes different bone tumor microenvironments depending on the tumor cells' origin. Here, we propose a novel insight on tumor-secreted Galectin-3 (Gal-3) that controls the induction of an inflammatory cascade, differentiation of osteoblasts, osteoclasts, and bone marrow cells, resulting in bone destruction and therapeutic failure...
June 2016: Cancer Metastasis Reviews
Richard M Cubbon, Alexander R Lyon
Substantial progress in cancer therapy increasingly allows higher cure rates, and even advanced disease can be stabilized, allowing improved survival with quality of life for months to years, meaning comorbid diseases are a growing determinant of outcome. Cardiovascular events substantially contribute to long-term morbidity and mortality in people living with or surviving cancer. In recognition of this, the subspecialty of cardio-oncology has emerged, and aims to promote cardiovascular heath, whilst facilitating the most effective cancer therapy...
April 2016: Indian Heart Journal
Niloofar Dehghan, Michael D McKee, Richard J Jenkinson, Emil H Schemitsch, Venessa Stas, Aaron Nauth, Jeremy A Hall, David J Stephen, Hans J Kreder
OBJECTIVES: The aim of this study was to compare early weightbearing and range of motion (ROM) to nonweightbearing and immobilization in a cast after surgical fixation of unstable ankle fractures. DESIGN: Multicentre randomized controlled trial. SETTING: Two-level one trauma centers. PATIENTS: One hundred ten patients who underwent open reduction and internal fixation of an unstable ankle fracture were recruited and randomized...
July 2016: Journal of Orthopaedic Trauma
Heath D Skinner, Uma Giri, Liang Yang, Sang Hyeok Woo, Michael D Story, Curtis R Pickering, Lauren A Byers, Michelle D Williams, Adel El-Naggar, Jing Wang, Lixia Diao, Li Shen, You Hong Fan, David P Molkentine, Beth M Beadle, Raymond E Meyn, Jeffrey N Myers, John V Heymach
PURPOSE: Head and neck squamous cell carcinoma (HNSCC) is commonly treated with radiotherapy, and local failure after treatment remains the major cause of disease-related mortality. To date, human papillomavirus (HPV) is the only known clinically validated, targetable biomarkers of response to radiation in HNSCC. EXPERIMENTAL DESIGN: We performed proteomic and transcriptomic analysis of targetable biomarkers of radioresistance in HPV-negative HNSCC cell lines in vitro, and tested whether pharmacologic blockade of candidate biomarkers sensitized cells to radiotherapy...
September 15, 2016: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Norberto Perico, Giuseppe Remuzzi
Chronic kidney disease (CKD) is an important determinant of the poor health outcome for major noncommunicable diseases that are the leading cause of death worldwide. Early recognition with screening programs of CKD and co-morbid conditions, like hypertension, diabetes, or toxic environments, can potentially slow progression to renal failure, improve quality of life and reduce healthcare cost. Effective multimodal tools are available to prevent CKD by managing its risk factors, and to slow or even halt disease progression to end-stage renal failure (ESRF)...
April 2016: Internal and Emergency Medicine
Emily K Don, Tanya A de Jong-Curtain, Karen Doggett, Thomas E Hall, Benjamin Heng, Andrew P Badrock, Claire Winnick, Garth A Nicholson, Gilles J Guillemin, Peter D Currie, Daniel Hesselson, Joan K Heath, Nicholas J Cole
Here we genetically characterise pelvic finless, a naturally occurring model of hindlimb loss in zebrafish that lacks pelvic fin structures, which are homologous to tetrapod hindlimbs, but displays no other abnormalities. Using a hybrid positional cloning and next generation sequencing approach, we identified mutations in the nuclear localisation signal (NLS) of T-box transcription factor 4 (Tbx4) that impair nuclear localisation of the protein, resulting in altered gene expression patterns during pelvic fin development and the failure of pelvic fin development...
2016: Biology Open
Daniel E Spratt, Beth M Beadle, Zachary S Zumsteg, Andrew Rivera, Heath D Skinner, Joseph R Osborne, Adam S Garden, Nancy Y Lee
PURPOSE: Local control in oropharyngeal cancer has improved to unprecedented rates with combined modality therapy; as a result, distant metastases are becoming a principal challenge. We aimed to determine the impact of diabetes mellitus and metformin use on clinical outcomes in a large population of oropharyngeal cancer patients treated in the modern era. METHODS AND MATERIALS: We identified 1745 consecutive patients with oropharyngeal cancer treated at 2 large cancer centers with external beam radiation therapy from 1998 to 2011...
March 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Patrick E Vaughan, Michael W Orth, Roger C Haut, Darrin M Karcher
While conventional mechanical testing has been regarded as a gold standard for the evaluation of bone heath in numerous studies, with recent advances in medical imaging, virtual methods of biomechanics are rapidly evolving in the human literature. The objective of the current study was to evaluate the feasibility of determining the elastic and failure properties of poultry long bones using established methods of analysis from the human literature. In order to incorporate a large range of bone sizes and densities, a small number of specimens were utilized from an ongoing study of Regmi et al...
January 2016: Poultry Science
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