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https://www.readbyqxmd.com/read/27886864/an-autopsy-case-of-refractory-pulmonary-hypertension-with-sarcoidosis
#1
Hiroki Ota, Keishi Sugino, Toshimasa Uekusa, Tamiko Takemura, Sakae Homma
A 63-year-old man with sarcoidosis-associated pulmonary hypertension (SAPH) died suddenly of decompensated right heart failure. At autopsy, microscopy showed subpleural and interlobular fibrosis in both upper lobes, with marked broncho-bronchiolectasis, as well as bronchovascular bundle fibrosis and fibrotic organization in alveolar lumens, which are consistent with pulmonary sarcoidosis. Intimal fibrosis and medial hypertrophy were noted in the proximal elastic to distal muscular pulmonary arteries (Heath-Edwards, grades II-III) within intensive fibrotic lesions...
November 2016: Respiratory Investigation
https://www.readbyqxmd.com/read/27878076/nonmotorized-recreation-and-motorized-recreation-in-shrub-steppe-habitats-affects-behavior-and-reproduction-of-golden-eagles-aquila-chrysaetos
#2
Robert J Spaul, Julie A Heath
Different forms of outdoor recreation have different spatiotemporal activity patterns that may have interactive or cumulative effects on wildlife through human disturbance, physical habitat change, or both. In western North America, shrub-steppe habitats near urban areas are popular sites for motorized recreation and nonmotorized recreation and can provide important habitat for protected species, including golden eagles. Our objective was to determine whether recreation use (i.e., number of recreationists) or recreation features (e...
November 2016: Ecology and Evolution
https://www.readbyqxmd.com/read/27863248/%C3%AE-glucan-reverses-the-epigenetic-state-of-lps-induced-immunological-tolerance
#3
Boris Novakovic, Ehsan Habibi, Shuang-Yin Wang, Rob J W Arts, Robab Davar, Wout Megchelenbrink, Bowon Kim, Tatyana Kuznetsova, Matthijs Kox, Jelle Zwaag, Filomena Matarese, Simon J van Heeringen, Eva M Janssen-Megens, Nilofar Sharifi, Cheng Wang, Farid Keramati, Vivien Schoonenberg, Paul Flicek, Laura Clarke, Peter Pickkers, Simon Heath, Ivo Gut, Mihai G Netea, Joost H A Martens, Colin Logie, Hendrik G Stunnenberg
Innate immune memory is the phenomenon whereby innate immune cells such as monocytes or macrophages undergo functional reprogramming after exposure to microbial components such as lipopolysaccharide (LPS). We apply an integrated epigenomic approach to characterize the molecular events involved in LPS-induced tolerance in a time-dependent manner. Mechanistically, LPS-treated monocytes fail to accumulate active histone marks at promoter and enhancers of genes in the lipid metabolism and phagocytic pathways. Transcriptional inactivity in response to a second LPS exposure in tolerized macrophages is accompanied by failure to deposit active histone marks at promoters of tolerized genes...
November 17, 2016: Cell
https://www.readbyqxmd.com/read/27860831/the-integrative-physiology-of-insect-chill-tolerance
#4
Johannes Overgaard, Heath A MacMillan
Cold tolerance is important in defining the distribution of insects. Here, we review the principal physiological mechanisms underlying homeostatic failure during cold exposure in this diverse group of ectotherms. Chillsusceptible insects are characterized by an initial loss of neuromuscular function (chill coma) that is caused by decreased membrane potential and reduced excitability of the neuromuscular system. Chronic or severe chilling causes a disruption of ion and water homeostasis across membranes and epithelia that exacerbate the initial effects of chilling on membrane potential and cellular function, and these perturbations are tightly associated with the development of chill injury and mortality...
November 16, 2016: Annual Review of Physiology
https://www.readbyqxmd.com/read/27821509/approach-to-the-diagnosis-and-treatment-of-high-grade-b-cell-lymphomas-with-myc-and-bcl2-and-or-bcl6-rearrangements
#5
Pierre Sesques, Nathalie A Johnson
High grade B cell lymphomas (HGBL) with MYC and BCL2 and/or BCL6 rearrangements, so-called "double hit" lymphomas (HGBL-DH), are aggressive lymphomas that form a separate provisional entity in the 2016 revised World Heath Organization Classification of Lymphoid Tumours. Fluorescence in situ hybridization (FISH) will be required to identify HGBL-DH and will re-classify a subset of diffuse large B cell lymphomas (DLBCL) and HGBL with features intermediate between DLBCL and Burkitt lymphoma into this new category...
November 7, 2016: Blood
https://www.readbyqxmd.com/read/27599938/streptococcus-iniae-cpsg-alters-capsular-carbohydrate-composition-and-is-a-cause-of-serotype-switching-in-vaccinated-fish
#6
Candice Heath, Christine M Gillen, Panagiotis Chrysanthopoulos, Mark J Walker, Andrew C Barnes
Streptococcus iniae causes septicaemia and meningitis in marine and freshwater fish wherever they are farmed in warm-temperate and tropical regions. Although serotype specific, vaccination with bacterins (killed bacterial cultures) is largely successful and vaccine failure occurs only occasionally through emergence of new capsular serotypes. Previously we showed that mutations in vaccine escapes are restricted to a limited repertoire of genes within the 20-gene capsular polysaccharide (cps) operon. cpsG, a putative UDP-galactose 4-epimerase, has three sequence types based on the insertion or deletion of the three amino acids leucine, serine and lysine in the substrate binding site of the protein...
September 25, 2016: Veterinary Microbiology
https://www.readbyqxmd.com/read/27575796/improving-heart-failure-outcomes-the-role-of-the-clinical-nurse-specialist
#7
Jennifer Coen, Kimberly Curry
This article identifies and explains barriers to optimal outcomes of heart failure and the role of the clinical nurse specialist in overcoming these obstacles, improving patient outcomes and quality of life. In recent years, advances in heart failure management have increased survival rates, and as a result, the number of patients requiring services to manage disease progression and the complex array of symptoms associated with end-stage heart disease. Management of the heart failure patient is dependent on the severity of the disease and wide range of available treatment regimens...
October 2016: Critical Care Nursing Quarterly
https://www.readbyqxmd.com/read/27553752/pharmacokinetics-and-dosing-of-anti-infective-drugs-in-patients-on-extracorporeal-membrane-oxygenation-a-review-of-the-current-literature
#8
REVIEW
Jennifer Sherwin, Travis Heath, Kevin Watt
PURPOSE: Extracorporeal membrane oxygenation (ECMO) is a cardiopulmonary bypass device that is used to temporarily support the most critically ill of patients with respiratory and/or cardiac failure. Infection and its sequelae may be an indication for ECMO or infections may be acquired while on ECMO and are associated with a mortality >50%. Effective therapy requires optimal dosing. However, optimal dosing can be different in patients on ECMO because the ECMO circuit can alter drug pharmacokinetics...
September 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27539135/native-bivalvular-endocarditis-by-gemella-haemolysans-requiring-venovenous-extracorporeal-membrane-oxygenation
#9
Akika Ando, Jaclyn Kagihara, Heath Chung, Dennis Thomas Bolger
A 24-year-old otherwise healthy man presented with a 3-week history of malaise, headache, fever and rigors after he was treated with oral clindamycin for left parotitis and Gemella haemolysans bacteraemia. He developed G. haemolysans infective endocarditis, septic emboli and heart failure due to progressive bivalvular disease. He underwent urgent mechanical aortic valve replacement and mitral valve repair, which required venovenous extracorporeal membrane oxygenation, to support severe respiratory failure. This is the first documented case of G...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27389523/expanding-the-phenotype-of-trnt1-related-immunodeficiency-to-include-childhood-cataract-and-inner-retinal-dysfunction
#10
Sarah Hull, Aeesha N J Malik, Gavin Arno, Donna S Mackay, Vincent Plagnol, Michel Michaelides, Sahar Mansour, Assunta Albanese, Katrina Tatton Brown, Graham E Holder, Andrew R Webster, Paul T Heath, Anthony T Moore
IMPORTANCE: A multiorgan syndromic disorder characterized by sideroblastic anemia, immunodeficiency, periodic fever, and developmental delay with an uncharacterized retinal dystrophy is caused by TRNT1. This report of a family with a homozygous mutation in TRNT1 expands the ocular phenotype to include cataract and inner retinal dysfunction and details a mild systemic phenotype. OBSERVATIONS: A consanguineous family with 3 affected children was investigated. Key clinical features comprised hypogammaglobulinemia, short stature with microcephaly, cataract, and inner retinal dysfunction without sideroblastic anemia or developmental delay...
September 1, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27357313/the-kidney-an-organ-in-the-front-line-of-oxidative-stress-associated-pathologies
#11
Yves Gorin
Both acute kidney injury (AKI) and chronic kidney disease (CKD) are major causes of renal failure in humans and are associated with high incidences of morbidity and mortality rates. AKI and CKD are closely interconnected, and fueled by the obesity and diabetes epidemic, their prevalence is alarmingly increasing to the point that it currently represents a major heath issue worldwide. The kidney is an organ that is particularly sensitive to redox imbalance, resulting in excessive production of reactive oxygen species...
October 20, 2016: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/27336466/phase-i-trial-of-consolidative-radiotherapy-with-concurrent-bevacizumab-erlotinib-and-capecitabine-for-unresectable-pancreatic-cancer
#12
Awalpreet S Chadha, Heath D Skinner, Jillian R Gunther, Mark F Munsell, Prajnan Das, Bruce D Minsky, Marc E Delclos, Deyali Chatterjee, Huamin Wang, Marilyn Clemons, Geena George, Pankaj K Singh, Matthew H Katz, Jason B Fleming, Milind M Javle, Robert A Wolff, Gauri R Varadhachary, Christopher H Crane, Sunil Krishnan
PURPOSE: To determine the safety, tolerability and maximum tolerated dose (MTD) of addition of erlotinib to bevacizumab and capecitabine-based definitive chemoradiation (CRT) in unresectable pancreatic cancer. METHODS: Seventeen patients with CT-staged, biopsy-proven unresectable pancreatic cancer were enrolled between 3/2008 and 10/2010. Prior chemotherapy was permitted. Two patients each were enrolled at dose levels (DLs) 1-4 and 9 patients at DL 5. All patients received 50...
2016: PloS One
https://www.readbyqxmd.com/read/27282802/a-novel-smarcal1-missense-mutation-that-affects-splicing-in-a-severely-affected-schimke-immunoosseous-dysplasia-patient
#13
Jimena Barraza-García, Carlos I Rivera-Pedroza, Alberta Belinchón, Carlota Fernández-Camblor, Blanca Valenciano-Fuente, Pablo Lapunzina, Karen E Heath
Schimke immunoosseous dysplasia (SIOD) is an autosomal recessive disease characterized by skeletal dysplasia, focal segmental glomerulosclerosis, renal failure and immunodeficiency. In this work, we report the molecular studies undertaken in a severely affected SIOD patient that died at six years old due to nephropathy. The patient was screened for mutations using a targeted skeletal dysplasias panel. A homozygous novel missense mutation was identified, c.1615C > G (p.[Leu539Val]) that was predicted as mildly pathogenic by in silico pathogenicity prediction tools...
August 2016: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/27281277/the-medial-stitch-in-transosseous-equivalent-rotator-cuff-repair-vertical-or-horizontal-mattress
#14
Anthony Montanez, Christopher A Makarewich, Robert T Burks, Heath B Henninger
BACKGROUND: Despite advances in surgical technique, rotator cuff repair retears continue to occur at rates of 10%, 22%, and 57% for small, medium, and large tears, respectively. A common mode of failure in transosseous-equivalent rotator cuff repairs is tissue pullout of the medial mattress stitch. While the medial mattress stitch has been studied extensively, no studies have evaluated a vertical mattress pattern placed near the musculotendinous junction in comparison with a horizontal mattress pattern...
September 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27153143/use-of-the-modified-frailty-index-to-predict-30-day-morbidity-and-mortality-from-spine-surgery
#15
Rushna Ali, Jason M Schwalb, David R Nerenz, Heath J Antoine, Ilan Rubinfeld
OBJECTIVE Limited tools exist to stratify perioperative risk in patients undergoing spinal procedures. The modified frailty index (mFI) based on the Canadian Study of Health and Aging Frailty Index (CSHA-FI), constructed from standard demographic variables, has been applied to various other surgical populations for risk stratification. The authors hypothesized that it would be predictive of postoperative morbidity and mortality in patients undergoing spine surgery. METHODS The 2006-2010 National Surgical Quality Improvement Program (NSQIP) data set was accessed for patients undergoing spine surgeries based on Current Procedural Terminology (CPT) codes...
May 6, 2016: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/27151720/aids-related-lymphoma-in-a-young-hiv-late-presenter-patient
#16
Manuela Arbune, Costinela Valerica Georgescu, Doina Carina Voinescu
Non-Hodgkin's lymphoma (NHL) is an acquired immunodeficiency syndrome (AIDS)-indicative disease. Nowadays, NHL is rarely reported in Europe as indicative disease for human immunodeficiency virus (HIV) testing. We present the case of a 22-year-old Romanian male patient without past medical history, except the swelling of a submental lymph node 11 months ago. The excised node was histologically examined but the patient neglected to take his result. He was admitted for fever, asthenia, and weight loss over 10% of his weight, and night sweats in the last four months...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27084653/clinical-outcomes-and-patterns-of-disease-recurrence-after-intensity-modulated-proton-therapy-for-oropharyngeal-squamous-carcinoma
#17
G Brandon Gunn, Pierre Blanchard, Adam S Garden, X Ronald Zhu, C David Fuller, Abdallah S Mohamed, William H Morrison, Jack Phan, Beth M Beadle, Heath D Skinner, Erich M Sturgis, Merrill S Kies, Kate A Hutcheson, David I Rosenthal, Radhe Mohan, Michael T Gillin, Steven J Frank
PURPOSE: A single-institution prospective study was conducted to assess disease control and toxicity of proton therapy for patients with head and neck cancer. METHODS AND MATERIALS: Disease control, toxicity, functional outcomes, and patterns of failure for the initial cohort of patients with oropharyngeal squamous carcinoma (OPC) treated with intensity modulated proton therapy (IMPT) were prospectively collected in 2 registry studies at a single institution. Locoregional failures were analyzed by using deformable image registration...
May 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27067726/galectin-3-in-bone-tumor-microenvironment-a-beacon-for-individual-skeletal-metastasis-management
#18
Kosei Nakajima, Dong Hyo Kho, Takashi Yanagawa, Melissa Zimel, Elisabeth Heath, Victor Hogan, Avraham Raz
The skeleton is frequently a secondary growth site of disseminated cancers, often leading to painful and devastating clinical outcomes. Metastatic cancer distorts bone marrow homeostasis through tumor-derived factors, which shapes different bone tumor microenvironments depending on the tumor cells' origin. Here, we propose a novel insight on tumor-secreted Galectin-3 (Gal-3) that controls the induction of an inflammatory cascade, differentiation of osteoblasts, osteoclasts, and bone marrow cells, resulting in bone destruction and therapeutic failure...
June 2016: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/27056658/cardio-oncology-concepts-and-practice
#19
REVIEW
Richard M Cubbon, Alexander R Lyon
Substantial progress in cancer therapy increasingly allows higher cure rates, and even advanced disease can be stabilized, allowing improved survival with quality of life for months to years, meaning comorbid diseases are a growing determinant of outcome. Cardiovascular events substantially contribute to long-term morbidity and mortality in people living with or surviving cancer. In recognition of this, the subspecialty of cardio-oncology has emerged, and aims to promote cardiovascular heath, whilst facilitating the most effective cancer therapy...
April 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27045369/early-weightbearing-and-range-of-motion-versus-non-weightbearing-and-immobilization-after-open-reduction-and-internal-fixation-of-unstable-ankle-fractures-a-randomized-controlled-trial
#20
Niloofar Dehghan, Michael D McKee, Richard J Jenkinson, Emil H Schemitsch, Venessa Stas, Aaron Nauth, Jeremy A Hall, David J Stephen, Hans J Kreder
OBJECTIVES: The aim of this study was to compare early weightbearing and range of motion (ROM) to nonweightbearing and immobilization in a cast after surgical fixation of unstable ankle fractures. DESIGN: Multicentre randomized controlled trial. SETTING: Two-level one trauma centers. PATIENTS: One hundred ten patients who underwent open reduction and internal fixation of an unstable ankle fracture were recruited and randomized...
July 2016: Journal of Orthopaedic Trauma
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