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https://www.readbyqxmd.com/read/29764435/use-of-hospital-palliative-care-according-to-the-place-of-death-and-disease-one-year-before-death-in-2013-a-french-national-observational-study
#1
Claire Poulalhon, Laureen Rotelli-Bihet, Sébastien Moine, Anne Fagot-Campagna, Régis Aubry, Philippe Tuppin
BACKGROUND: Only limited data are available concerning the diseases managed before death and hospital palliative care (HPC) use according to place of death in France. We therefore conducted an observational study based on administrative health data in a large population to identify the diseases treated one year before death in 2013, the place of stay with or without hospital palliative care, and the place of death. METHODS: French health insurance general scheme beneficiaries were identified in the National Health data Information System (Snds) with a selection of information...
May 16, 2018: BMC Palliative Care
https://www.readbyqxmd.com/read/29746522/changes-in-quality-of-life-and-health-status-in-patients-with-extracorporeal-life-support-a-prospective-longitudinal-study
#2
Kang-Hua Chen, Yu-Ting Chen, Shu-Ling Yeh, Li-Chueh Weng, Feng-Chun Tsai
BACKGROUND: Extracorporeal life support (ECLS) provides emergency pulmonary and cardiac assistance for patients in respiratory or cardiac failure. Most studies evaluate the success of ECLS based on patients' survival rate. However, the trajectory of health status and quality of life (QOL) should also be important considerations. The study's aim was to explore changes in health status and QOL in adult patients weaned from ECLS who survived to hospital discharge over a one-year period. STUDY DESIGN: A prospective longitudinal study was conducted from April 2012 to September 2014...
2018: PloS One
https://www.readbyqxmd.com/read/29743227/using-the-quadruple-aim-framework-to-measure-impact-of-heath-technology-implementation-a-case-study-of-econsult
#3
Clare Liddy, Erin Keely
BACKGROUND: Health technology solutions are too often implemented without a true understanding of the system-level problem they seek to address, resulting in excessive costs, poor adoption, ineffectiveness, and ultimately failure. Before implementing or adopting health care innovations, stakeholders should complete a thorough assessment to ensure effectiveness and value. In this article, we describe how to evaluate the impact of a health technology innovation through the 4 dimensions of care outlined by the Quadruple Aim Framework, using our experience with the Champlain Building Access to Specialists through eConsultation (BASE) eConsult service as a case example...
May 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29694379/short-term-microbial-effects-of-a-large-scale-mine-tailing-storage-facility-collapse-on-the-local-natural-environment
#4
Heath W Garris, Susan A Baldwin, Jon Taylor, David B Gurr, Daniel R Denesiuk, Jonathan D Van Hamme, Lauchlan H Fraser
We investigated the impacts of the Mount Polley tailings impoundment failure on chemical, physical, and microbial properties of substrates within the affected watershed, comprised of 70 hectares of riparian wetlands and 40 km of stream and lake shore. We established a biomonitoring network in October of 2014, two months following the disturbance, and evaluated riparian and wetland substrates for microbial community composition and function via 16S and full metagenome sequencing. A total of 234 samples were collected from substrates at 3 depths and 1,650,752 sequences were recorded in a geodatabase framework...
2018: PloS One
https://www.readbyqxmd.com/read/29627106/clinical-features-associated-with-nascent-left-ventricular-diastolic-dysfunction-in-a-population-aged-40-to-55-years
#5
Jonathan D Mosley, Rebecca T Levinson, Evan L Brittain, Deepak K Gupta, Eric Farber-Eger, Christian M Shaffer, Josh C Denny, Dan M Roden, Quinn S Wells
Diastolic dysfunction (DD), an abnormality in cardiac left ventricular (LV) chamber compliance, is associated with increased morbidity and mortality. Although DD has been extensively studied in older populations, co-morbidity patterns are less well characterized in middle-aged subjects. We screened 156,434 subjects with transthoracic echocardiogram reports available through Vanderbilt's electronic heath record and identified 6,612 subjects 40 to 55 years old with an LV ejection fraction ≥50% and diastolic function staging...
March 13, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29536934/improving-diagnosis-in-health-care-perspectives-from-the-american-college-of-radiology
#6
REVIEW
Bibb Allen, Mythreyi Chatfield, Judy Burleson, William T Thorwarth
In September of 2014, the American College of Radiology joined a number of other organizations in sponsoring the 2015 National Academy of Medicine report, Improving Diagnosis In Health Care. Our presentation to the Academy emphasized that although diagnostic errors in imaging are commonly considered to result only from failures in disease detection or misinterpretation of a perceived abnormality, most errors in diagnosis result from failures in information gathering, aggregation, dissemination and ultimately integration of that information into our patients' clinical problems...
September 26, 2017: Diagnosis
https://www.readbyqxmd.com/read/29518628/aml-refractory-to-primary-induction-with-ida-flag-has-a-poor-clinical-outcome
#7
Simon Kavanagh, Emily Heath, Rose Hurren, Marcela Gronda, Samir H Barghout, Sanduni U Liyanage, Thirushi P Siriwardena, Jaime Claudio, Tong Zhang, Mahadeo Sukhai, Tracy L Stockley, Suzanne Kamel-Reid, Amr Rostom, Andrzej Lutynski, Dina Khalaf, Anna Rydlewski, Steven M Chan, Vikas Gupta, Dawn Maze, Hassan Sibai, Andre C Schuh, Karen Yee, Mark D Minden, Aaron D Schimmer
We evaluated outcomes of 100 patients with high risk AML treated with Ida-FLAG induction as first-line therapy. 72 achieved remission with one cycle; 19 did not. High risk cytogenetics and TP53 mutations were associated with failure to achieve remission. In those reaching remission, allogeneic bone marrow transplantation was associated with better relapse-free and overall survival. Those not achieving remission with induction therapy were extremely unlikely to reach remission with further therapy and had a dismal prognosis...
May 2018: Leukemia Research
https://www.readbyqxmd.com/read/29410351/fibroblast-growth-factor-21-in-cardio-metabolic-disorders-a-systematic-review-and-meta-analysis
#8
Ishan Lakhani, Mengqi Gong, Wing Tak Wong, George Bazoukis, Konstantinos Lampropoulos, Sunny Hei Wong, William K K Wu, Martin C S Wong, Kwok-Leung Ong, Tong Liu, Gary Tse
BACKGROUND: Fibroblast growth factor 21 is a signalling protein involved in cell differentiation, morphogenesis, proliferation and metabolism. Recent studies have associated increased levels of FGF21 in the development of cardiovascular diseases, whereas others have reported no significant associations. Therefore, this systematic review and meta-analysis evaluated the its value in predicting the risk of cardio-metabolic disorders and mortality. METHODS: PubMed and EMBASE were searched until 5th September 2017 for studies that evaluated the roles of FGF21 levels in cardio-metabolic disorders...
February 1, 2018: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/29382725/the-small-heat-shock-protein-hsp27-binds-%C3%AE-synuclein-fibrils-preventing-elongation-and-cytotoxicity
#9
Dezerae Cox, Daniel R Whiten, James W P Brown, Mathew H Horrocks, Rebecca San Gil, Christopher M Dobson, David Klenerman, Antoine M van Oijen, Heath Ecroyd
Proteostasis, or protein homeostasis, encompasses the maintenance of the conformational and functional integrity of the proteome and involves an integrated network of cellular pathways. Molecular chaperones, such as the small heat shock proteins (sHsps), are key elements of the proteostasis network that have crucial roles in inhibiting the aggregation of misfolded proteins. Failure of the proteostasis network can lead to the accumulation of misfolded proteins into intracellular and extracellular deposits. Deposits containing fibrillar forms of α-synuclein (α-syn) are characteristic of neurodegenerative disorders including Parkinson's disease and dementia with Lewy bodies...
March 23, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29332241/atrial-fibrillation-is-associated-with-sudden-cardiac-death-a-systematic-review-and-meta-analysis
#10
Pattara Rattanawong, Sikarin Upala, Tanawan Riangwiwat, Veeravich Jaruvongvanich, Anawin Sanguankeo, Wasawat Vutthikraivit, Eugene H Chung
PURPOSE: Recent studies suggest that atrial fibrillation (AF) is associated with increased cardiovascular risk and mortality including sudden cardiac death (SCD). According to the Cardiovascular Heath Study cohort, the incident rate of SCD was higher in the AF population (2.9 per 1000 per year) compared with non-AF controls (1.3 per 1000 per year). In this study, we performed a systematic review and meta-analysis to explore the association between AF and SCD. METHODS: We comprehensively searched the databases of MEDLINE and EMBASE from inception to January 2017...
March 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29286825/is-treatment-of-segond-fracture-necessary-with-combined-anterior-cruciate-ligament-reconstruction
#11
Heath P Melugin, Nick R Johnson, Isabella T Wu, Bruce A Levy, Michael J Stuart, Aaron J Krych
BACKGROUND: There is a paucity of clinical information to guide the treatment of a combined anterior cruciate ligament (ACL) tear and Segond fracture. PURPOSE: To compare clinical outcomes, graft failure rates, and activity levels between patients undergoing ACL reconstruction (ACLR) with and without an untreated Segond fracture at a minimum 2-year follow-up. STUDY DESIGN: Cohort study; Level of evidence, 3. METHODS: This study included a group of patients with a combined ACL tear/untreated Segond fracture that was matched based on age, sex, body mass index, and graft type to a control group of patients with an ACL tear and no Segond fracture...
March 2018: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/29261703/transhumeral-loading-during-advanced-upper-extremity-activities-of-daily-living
#12
Alex J Drew, Morgan T Izykowski, Kent N Bachus, Heath B Henninger, K Bo Foreman
Percutaneous osseointegrated (OI) implants for direct skeletal attachment of upper extremity prosthetics represent an alternative to traditional socket suspension that may yield improved patient function and satisfaction. This is especially true in high-level, transhumeral amputees where prosthetic fitting is challenging and abandonment rates remain high. However, maintaining mechanical integrity of the bone-implant interface is crucial for safe clinical introduction of this technology. The collection of population data on the transhumeral loading environment will aid in the design of compliance and overload protection devices that mitigate the risk of periprosthetic fracture...
2017: PloS One
https://www.readbyqxmd.com/read/29242584/mis-expression-of-grainyhead-like-transcription-factors-in-zebrafish-leads-to-defects-in-enveloping-layer-evl-integrity-cellular-morphogenesis-and-axial-extension
#13
Lee B Miles, Charbel Darido, Jan Kaslin, Joan K Heath, Stephen M Jane, Sebastian Dworkin
The grainyhead-like (grhl) transcription factors play crucial roles in craniofacial development, epithelial morphogenesis, neural tube closure, and dorso-ventral patterning. By utilising the zebrafish to differentially regulate expression of family members grhl2b and grhl3, we show that both genes regulate epithelial migration, particularly convergence-extension (CE) type movements, during embryogenesis. Genetic deletion of grhl3 via CRISPR/Cas9 results in failure to complete epiboly and pre-gastrulation embryonic rupture, whereas morpholino (MO)-mediated knockdown of grhl3 signalling leads to aberrant neural tube morphogenesis at the midbrain-hindbrain boundary (MHB), a phenotype likely due to a compromised overlying enveloping layer (EVL)...
December 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29182364/how-journalists-characterize-health-inequalities-and-redefine-solutions-for-native-american-audiences
#14
Amanda Hinnant, Roma Subramanian, Rokeshia Renné Ashley, Mimi Perreault, Rachel Young, Ryan J Thomas
Many Native American communities experience severe health inequalities, including shorter average lifespan and higher rates of chronic illnesses. Journalism that serves Native Americans is a promising channel for heath communication, but only if scholars first understand the particular cultural contexts of indigenous communities. This research contributes to that goal by investigating how journalists serving Native American communities characterize health and the issues they identify with covering determinants of health...
November 28, 2017: Health Communication
https://www.readbyqxmd.com/read/29113987/bap1-is-a-novel-target-in-hpv-negative-head-and-neck-cancer
#15
Xiyou Liu, Manish Kumar, Liangpeng Yang, David P Molkentine, David Valdecanas, Shiying Yu, Raymond E Meyn, John V Heymach, Heath D Skinner
Purpose: This study examined the potential role of the nuclear deubiquitinating enzyme BRCA1-associated protein-1 (BAP1) in radioresistance in head and neck squamous cell cancer (HNSCC). Experimental Design: We overexpressed, knocked down, and rescued BAP1 expression in six HNSCC cell lines, three human papillomavirus (HPV)-negative and three HPV-positive, and examined the effects on radiosensitivity in vitro and in an HNSCC mouse xenograft model. Radiosensitivity was assessed by clonogenic cell survival and tumor growth delay assays; changes in protein expression were analyzed by immunofluorescence staining and Western blotting...
February 1, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29079260/biomechanical-comparison-of-transosseous-knotless-rotator-cuff-repair-versus-transosseous-equivalent-repair-half-the-anchors-with-equivalent-biomechanics
#16
Robert Z Tashjian, Robert W Hoy, Joel R Helgerson, Andrew D Guss, Heath B Henninger, Robert T Burks
PURPOSE: To compare the biomechanics of a transosseous equivalent (TOE) repair using medial and lateral anchors with tape to a transosseous knotless (TOK) tape repair with only laterally placed intraosseous anchors. METHODS: One of 2 different repairs were performed on 8 paired specimens: (1) transosseous equivalent (TOE) tape repair or (2) transosseous knotless (TOK) tape repair. Specimens were mounted on a materials testing machine and loaded in uniaxial tension to measure cyclic construct gap formation, followed by failure testing...
January 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28955176/changes-in-muscle-metabolism-are-associated-with-phenotypic-variability-in-golden-retriever-muscular-dystrophy
#17
Peter P Nghiem, Luca Bello, William B Stoughton, Sara Mata López, Alexander H Vidal, Briana V Hernandez, Katherine N Hulbert, Taylor R Gourley, Amanda K Bettis, Cynthia J Balog-Alvarez, Heather Heath-Barnett, Joe N Kornegay
Duchenne muscular dystrophy (DMD) is an X-chromosome-linked disorder and the most common monogenic disease in people. Affected boys are diagnosed at a young age, become non-ambulatory by their early teens, and succumb to cardiorespiratory failure by their thirties. Despite being a monogenic condition resulting from mutations in the DMD gene, affected boys have noteworthy phenotypic variability. Efforts have identified genetic modifiers that could modify disease progression and be pharmacologic targets. Dogs affected with golden retriever muscular dystrophy (GRMD) have absent dystrophin and demonstrate phenotypic variability at the functional, histopathological, and molecular level...
September 2017: Yale Journal of Biology and Medicine
https://www.readbyqxmd.com/read/28948481/device-management-in-heart-failure
#18
REVIEW
Brett G Angel, Heath Saltzman, Luke S Kusmirek
PURPOSE OF REVIEW: Medical devices have become an integral part of comprehensive heart failure management. Not all heart failure patients, however, accrue benefit from every new device, and even with extensive practice guidelines, this remains an evolving field. RECENT FINDINGS: The addition of implantable devices, like internal cardioverter defibrillators (ICDs), and novel pacing technologies, including cardiac resynchronization therapy (CRT), have helped to compliment goal-directed medical therapy and positively impact prognosis in multiple high-quality clinical trials...
September 25, 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28862929/socioeconomic-status-and-incidence-of-hospitalization-with-lower-extremity-peripheral-artery-disease-atherosclerosis-risk-in-communities-study
#19
Priya Vart, Josef Coresh, Lucia Kwak, Shoshana H Ballew, Gerardo Heiss, Kunihiro Matsushita
BACKGROUND: Compared to coronary heart disease, heart failure, and stroke, the relationship between low socioeconomic status (SES) and peripheral artery disease (PAD) is less well established. We examined the association between SES and incidence of hospitalization with PAD and explored whether this association can be explained by traditional cardiovascular risk factors and healthcare access. METHODS AND RESULTS: A total of 12 517 participants in the Atherosclerosis Risk in Communities (ARIC) Study (1987-1989) with no prior PAD were examined...
August 10, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28862499/suspect-the-unexpected-a-45-year-old-man-with-fevers-rash-and-multiorgan-failure
#20
Janae K Heath, Katherine R Courtright
No abstract text is available yet for this article.
September 2017: Annals of the American Thoracic Society
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