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https://www.readbyqxmd.com/read/29346080/new-insight-into-the-action-of-tryptanthrins-against-plasmodium-falciparum-pharmacophore-identification-via-a-novel-submolecular-qsar-descriptor
#1
Joel A Olson, Raymond J Terryn, Elizabeth L Stewart, J Clayton Baum, Mark J Novak
A new submolecular quantitative structure activity relationship (QSAR) descriptor was applied toward elucidating the anti-malarial pharmacophore of tryptanthrins, a class of compounds known for their anti-parasitic activities. The new descriptor is based on experimental and computational measurements of the tunneling barriers of individual lobes of the molecular orbitals. Lobe-by-lobe QSAR correlation plots revealed a single lobe of the LUMO to be strongly associated with tryptanthrin's anti-malarial activity...
December 27, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29345110/remarkable-similarity-in-plasmodium-falciparum-and-plasmodium-vivax-geranylgeranyl-diphosphate-synthase-ggpps-dynamics-and-its-implication-for-anti-malarial-drug-design
#2
Aishwarya Venkatramani, Clarisse G Ricci, Eric Oldfield, J Andrew McCammon
Malaria, mainly caused by Plasmodium falciparum and Plasmodium vivax, has been a growing cause of morbidity and mortality. P. falciparum is more lethal than is P. vivax, but there is a vital need for effective drugs against both species. Geranylgeranyl diphosphate synthase (GGPPS) is an enzyme involved in the biosynthesis of quinones and in protein prenylation, and has been proposed to be a malaria drug target. However, the structure of P. falciparum GGPPS (PfGGPPS) has not been determined, due to difficulties in crystallization...
January 18, 2018: Chemical Biology & Drug Design
https://www.readbyqxmd.com/read/29338726/a-case-of-blackwater-fever-with-persistent-plasmodium-falciparum-parasitaemia-detected-by-pcr-after-artemether-lumefantrine-treatment
#3
Paul John Huggan, Chin Hin Ng, Jennifer Ho, Raymond Tzer Pin Valentine Lin, Jean-Marc Chavatte
BACKGROUND: Blackwater fever is a complication of malaria infection consisting of a syndrome of febrile intra-vascular haemolysis with severe anaemia and intermittent passage of dark-red to black colour urine. Despite numerous reports and studies of this condition, its pathogenesis remains incompletely understood. CASE PRESENTATION: This report describes a case of classic blackwater fever in a returning traveller, without prior history of malaria infection nor usage of anti-malarial prophylaxis, treated with two courses of oral artemether-lumefantrine combination therapy...
January 16, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29338720/manual-exchange-transfusion-for-severe-imported-falciparum-malaria-a-retrospective-study
#4
Jinfeng Lin, Xiaoying Huang, Gang Qin, Suyan Zhang, Weiwei Sun, Yadong Wang, Ke Ren, Junxian Xu, Xudong Han
BACKGROUND: This study was designed to evaluate the efficacy of exchange transfusion in patients with severe imported falciparum malaria. Twelve patients who met the diagnostic criteria for severe malaria were treated with exchange transfusion 14 times according to a conventional anti-malarial treatment. This study evaluated the efficacy of exchange transfusion for severe imported falciparum malaria. METHODS: Clinical data of severe imported falciparum malaria patients admitted to the intensive care unit (ICU) of Nantong Third People's Hospital from January 2007 to December 2016 were investigated in this retrospective study...
January 16, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29330325/cutting-edge-plasmodium-falciparum-induces-trained-innate-immunity
#5
Jacob E Schrum, Juliet N Crabtree, Katherine R Dobbs, Michael C Kiritsy, George W Reed, Ricardo T Gazzinelli, Mihai G Netea, James W Kazura, Arlene E Dent, Katherine A Fitzgerald, Douglas T Golenbock
Malarial infection in naive individuals induces a robust innate immune response. In the recently described model of innate immune memory, an initial stimulus primes the innate immune system to either hyperrespond (termed training) or hyporespond (tolerance) to subsequent immune challenge. Previous work in both mice and humans demonstrated that infection with malaria can both serve as a priming stimulus and promote tolerance to subsequent infection. In this study, we demonstrate that initial stimulation with Plasmodium falciparum-infected RBCs or the malaria crystal hemozoin induced human adherent PBMCs to hyperrespond to subsequent ligation of TLR2...
January 12, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29329539/state-dependent-domicile-leaving-rates-in-anopheles-gambiae
#6
Simon P W Zappia, Alex M Chubaty, Bernard D Roitberg
BACKGROUND: Transmission of Plasmodium greatly depends on the foraging behaviour of its mosquito vector (Anopheles spp.). The accessibility of blood hosts and availability of plant sugar (i.e., nectar) sources, together with mosquito energy state, have been shown to modulate blood feeding (and thus biting rates) of anopheline mosquitoes. In this study, the influence of mosquito starvation status and availability of nectar on the decision of female Anopheles gambiae mosquitoes to leave a bed net-protected blood host was examined...
January 12, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29322052/composition-of-anopheles-species-collected-from-selected-malarious-areas-of-afghanistan-and-iran
#7
Helen Hoosh-Deghati, Navid Dinparast-Djadid, Vahideh Moin-Vaziri, Hoda Atta, Abbas Ali Raz, Seyyed Javad Seyyed-Tabaei, Naseh Maleki-Ravasan, Hamzeh Alipour, Sedigheh Zakeri, Eznollah Azar-Gashb
Background: Malarious areas in Iran are close to Afghanistan and Pakistan that urge the researchers to extend their knowledge on malaria epidemiology to the neighboring countries as well. Vectorial capacity differs at species or even at population level, the first essential step is accurate identification of vectors. This study aimed to identify Anopheles species composition in selected malarious areas of Afghanistan and Iran, providing further applied data for other research in two countries...
September 2017: Journal of Arthropod-borne Diseases
https://www.readbyqxmd.com/read/29317419/cohort-profile-effect-of-malaria-in-early-pregnancy-on-fetal-growth-in-benin-recipal-preconceptional-cohort
#8
Manfred Accrombessi, Emmanuel Yovo, Gilles Cottrell, Gino Agbota, Agnès Gartner, Yves Martin-Prevel, Nadia Fanou-Fogny, Diane Djossinou, Jennifer Zeitlin, Nicaise Tuikue-Ndam, Florence Bodeau-Livinec, Sandrine Houzé, Nicola Jackson, Paul Ayemonna, Achille Massougbodji, Michel Cot, Nadine Fievet, Valérie Briand
PURPOSE: REtard de Croissance Intra-uterin et PALudisme (RECIPAL) is an original preconceptional cohort designed to assess the consequences of malaria during the first trimester of pregnancy, which is a poorly investigated period in Africa and during which malaria may be detrimental to the fetus. PARTICIPANTS: For this purpose, a total of 1214 women of reproductive age living in Sô-Ava and Akassato districts (south Benin) were followed up monthly from June 2014 to December 2016 until 411 of them became pregnant...
January 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29316932/why-do-people-participate-in-mass-anti-malarial-administration-findings-from-a-qualitative-study-in-nong-district-savannakhet-province-lao-pdr-laos
#9
Bipin Adhikari, Koukeo Phommasone, Palingnaphone Kommarasy, Xayaphone Soundala, Phonesavanh Souvanthong, Tiengkham Pongvongsa, Gisela Henriques, Paul N Newton, Nicholas J White, Nicholas P J Day, Arjen M Dondorp, Lorenz von Seidlein, Mayfong Mayxay, Phaik Yeong Cheah, Christopher Pell
BACKGROUND: As a part of targeted malaria elimination (TME) in the Greater Mekong Sub-region (GMS), mass drug administration (MDA) with anti-malarials was conducted in four villages in Nong District, Savannakhet Province, Lao PDR (Laos). A high proportion of the target population participated in the MDA, with over 87% agreeing to take the anti-malarial. Drawing on qualitative data collected alongside the MDA, this article explores the factors that led to this high population coverage...
January 9, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29316551/chloroquine-enhances-the-radiosensitivity-of-bladder-cancer-cells-by-inhibiting-autophagy-and-activating-apoptosis
#10
Feng Wang, Jinyuan Tang, Pengchao Li, Shuhui Si, Hao Yu, Xiao Yang, Jun Tao, Qiang Lv, Min Gu, Haiwei Yang, Zengjun Wang
BACKGROUND/AIMS: Chloroquine was formerly used as an anti-malarial agent drug but has now been proven to be useful for various diseases. This study aimed to investigate the radiosensitizing effect of chloroquine in bladder cancer, with an emphasis on autophagy inhibition and apoptosis induction. METHODS: Bladder cancer cell lines were irradiated with or without chloroquine. Cell proliferation was determined by a Cell Counting Kit 8 assay. The radiosensitization effect of chloroquine was evaluated by clonogenic survival and progression of xenograft tumors...
December 22, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29313573/p-vivax-malaria-presenting-as-thrombotic-microangiopathy
#11
Dharmendra Bhadauria, Harsh Vardhan, Anupma Kaul, Raj Kumar Sharma, Amit Gupta, Narayan Prasad, Manoj Jain
Introduction: Acute kidney injury (AKI) is reported to occur in patients with falciparum malaria but not uncommon with vivax malaria. AKI, anemia, thrombocytopenia and jaundice is a recurrent finding in severe malaria and can mimic as thrombotic microangiopathy (TMA). Relationship of malaria with TMA is unclear till date however evidences suggest their association. Methods & Material: We reviewed our electronic database to evaluate relationship of malaria with TMA, of cases of malaria, jaundice and AKI...
September 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29311435/preparative-separation-of-high-purity-dihydroartemisinic-acid-from-artemisinin-production-waste-by-combined-chromatography
#12
Shuoqian Liu, Jorge Freire da Silva Ferreira, Dongming Tian, Yuwei Tang, Liping Liu, Wei Yang, Zhonghua Liu, Na Tian
In order to make full use of artemisinin production waste and thus to reduce the production cost of artemisinin, we developed an efficient and scalable method to isolate high-purity dihydroartemisinic acid from artemisinin production waste by combining anion-exchange resin with silica-gel column chromatography. The adsorption and desorption characteristics of dihydroartemisinic acid on 10 types of anion-exchange resin were investigated, and the results showed that the 717 anion-exchange resin exhibited the highest capacity of adsorption and desorption to dihydroartemisinic acid...
December 28, 2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/29310609/self-medication-among-pregnant-women-attending-antenatal-clinic-at-makongoro-health-centre-in-mwanza-tanzania-a-challenge-to-health-systems
#13
Karol J Marwa, Agnes Njalika, Deodatus Ruganuza, Deogratias Katabalo, Erasmus Kamugisha
BACKGROUND: Self-medication is a universal challenge that requires attention because of the potential threat not only to the pregnant women but also to unborn child. Data on self-medication practice and predictors among pregnant women is lacking in Tanzania. Information on the effects of this practice to the pregnant woman and the foetus globally is also scanty. METHODS: This was a cross sectional study which was conducted using face to face interview with 372 pregnant women at Makongoro health centre...
January 8, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29304859/a-phase-1-evaluation-of-the-pharmacokinetic-pharmacodynamic-interaction-of-the-anti-malarial-agents-kaf156-and-piperaquine
#14
F Joel Leong, Jay Prakash Jain, Yiyan Feng, Budhaditya Goswami, Daniel S Stein
BACKGROUND: KAF156 is a novel imidazolopiperazine anti-malarial with activity against pre-erythrocytic liver stages, asexual and sexual blood stages. Based on in vitro data, a two-way pharmacokinetic interaction was hypothesized for KAF156 use in combination with piperaquine (PPQ) as both drugs are CYP3A4 substrates and inhibitors. Potential combination effects on the QT interval were also assessed. METHODS: This was an open-label, parallel-group, single-dose study in healthy volunteers randomized to three parallel arms (1:1:1) of 800 mg KAF156 + 1280 mg PPQ, 800 mg KAF156 alone and 1280 mg PPQ alone...
January 5, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29304798/-we-were-being-treated-like-the-queen-understanding-trial-factors-influencing-high-paediatric-malaria-treatment-adherence-in-western-kenya
#15
Caroline Jones, Ambrose O Talisuna, Robert W Snow, Dejan Zurovac
BACKGROUND: Adherence to anti-malarial medication is highly variable but frequently suboptimal. Numerous interventions with a variety of methodological approaches have been implemented to address the problem. A recently conducted, randomized, controlled trial in western Kenya evaluated the effects of short message service (SMS) reminders on paediatric adherence to artemether-lumefantrine (AL) and found over 97% adherence rates in both intervention and control arms. The current study was undertaken to explore participants' experiences in the trial and identify the factors contributing to the high adherence rates...
January 5, 2018: Malaria Journal
https://www.readbyqxmd.com/read/29301032/artemisinin-biosynthesis-promoting-kinase-1-positively-regulates-artemisinin-biosynthesis-through-phosphorylating-aabzip1
#16
Fangyuan Zhang, Lien Xiang, Qin Yu, Haoxing Zhang, Taixin Zhang, Junlan Zeng, Chen Geng, Ling Li, Xueqing Fu, Qian Shen, Chunxian Yang, Xiaozhong Lan, Min Chen, Kexuan Tang, Zhihua Liao
The plant Artemisia annua produces the anti-malarial compound artemisinin. Although the transcriptional regulation of artemisinin biosynthesis has been extensively studied, its post-translational regulatory mechanisms, especially that of protein phosphorylation, remain unknown. Here, we report that an ABA-responsive kinase (AaAPK1), a member of the SnRK2 family, is involved in regulating artemisinin biosynthesis. The physical interaction of AaAPK1 with AabZIP1 was confirmed by multiple assays, including yeast two-hybrid, bimolecular fluorescence complementation, and pull-down...
December 28, 2017: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29300748/functional-interrogation-of-plasmodium-genus-metabolism-identifies-species-and-stage-specific-differences-in-nutrient-essentiality-and-drug-targeting
#17
Alyaa M Abdel-Haleem, Hooman Hefzi, Katsuhiko Mineta, Xin Gao, Takashi Gojobori, Bernhard O Palsson, Nathan E Lewis, Neema Jamshidi
Several antimalarial drugs exist, but differences between life cycle stages among malaria species pose challenges for developing more effective therapies. To understand the diversity among stages and species, we reconstructed genome-scale models (GEMs) of metabolism for five life cycle stages and five species of Plasmodium spanning the blood, transmission, and mosquito stages. The stage-specific models of Plasmodium falciparum uncovered stage-dependent changes in central carbon metabolism and predicted potential targets that could affect several life cycle stages...
January 4, 2018: PLoS Computational Biology
https://www.readbyqxmd.com/read/29291234/a-clinical-report-on-mixed-infection-of-malaria-dengue-and-chikungunya-from-new-delhi-india
#18
Mohd Abdullah, Ayesha Tazeen, Malik Hisamuddin, Irshad H Naqvi, Hirday N Verma, Anwar Ahmed, Shama Parveen
Arthropod-borne infections like malaria, dengue and chikungunya fever are transmitted by mosquitoes. The present report describes an unusual case of mixed infection with malaria, dengue and chikungunya viruses in a 21 year old male patient from New Delhi, India during monsoon season of 2016. The malarial fever was diagnosed by thin slide microscopy and antigen test. Chikungunya virus IgM was detected in the sample by the card test. Dengue and chikungunya viruses were further confirmed by RT-PCR for CprM and E1 gene respectively...
December 2017: Virusdisease
https://www.readbyqxmd.com/read/29290967/modelling-the-effects-of-chloroquine-on-kcnj2-linked-short-qt-syndrome
#19
Cunjin Luo, Kuanquan Wang, Henggui Zhang
A gain-of-function KCNJ2 D172N mutation in KCNJ2-encoded Kir2.1 channels underlies one form of short QT syndrome (SQT3), which is associated with increased susceptibility to arrhythmias and sudden death. Anti-malarial drug chloroquine was reported as an effective inhibitor of Kir2.1 channels. Using biophysically-detailed human ventricle computer models, this study assessed the effects of chloroquine on SQT3. The ten Tusscher et al. model of human ventricular cell action potential was modified to recapitulate functional changes in the inward rectifier K+ current (IK1) due to heterozygous and homozygous forms of the D172N mutation...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29284476/why-some-sites-are-responding-better-to-anti-malarial-interventions-a-case-study-from-western-kenya
#20
Anthony Kapesa, Eliningaya J Kweka, Harrysone Atieli, Erasmus Kamugisha, Guofa Zhou, Andrew K Githeko, Guiyun Yan
BACKGROUND: In sub-Saharan Africa, malaria interventions over the last decades have been successful in reducing both mortality and morbidity. In western Kenya however some areas experience contrasting outcomes of the ongoing interventions while the causes for this observation remains not yet clearly known. METHODS: The WHO insecticide (deltamethrin) susceptibility test of the common malaria vectors was studied. Multiple surveys on household use and hospital prescriptions of antimalarial drugs from 2003 to 2015 were done...
December 29, 2017: Malaria Journal
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