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Hendrik Berth, Philipp Matthias Rohleder
INTRODUCTION: The emergency service is a challenging field of activity. The Effort-Reward Imbalance model explains on the basis of the ratio between reward/effort the appearance of occupational stress. For the first time, this study examines the extent of Effort-Reward Imbalance in rescue services in Germany. METHODS: Full-time emergency service employees of a German Red Cross District Association were consulted. N=82 employees (78.8%) participated (M age=37.78 years, 73...
July 19, 2018: Psychotherapie, Psychosomatik, Medizinische Psychologie
Victor Martin, Javier Sanchez-Sanchez, Rodrigo Ramírez-Campillo, Fábio Yuzo Nakamura, Oliver Gonzalo-Skok
The present study aimed to examine the reliability, usefulness, responsiveness, age-related differences and construct validity of a novel decision-making RSA test (RSA-RANDOM test) in young soccer players. Twenty-five young male soccer players performed the RSA-RANDOM test on 2 occasions separated by 5-7 days to assess test-retest reliability and determine a priori usefulness. Furthermore, the same players executed the RSA-RANDOM test 4 times throughout the season to analyse responsiveness. Forty-five players (U-13 to U-17) were evaluated in such test to examine age-related differences...
July 19, 2018: International Journal of Sports Medicine
Willemien S Kalteren, Hendrik J Ter Horst, Anne E den Heijer, Leanne de Vetten, Elisabeth M W Kooi, Arend F Bos
BACKGROUND: Perinatal anemia may cause perinatal asphyxia. Its pathophysiology and neurodevelopmental effects are theoretically different from other causes of perinatal asphyxia. OBJECTIVE: The study aimed to determine whether perinatal anemia results in different short-term and long-term outcomes than other causes of perinatal asphyxia treated with therapeutic hypothermia. METHODS: We retrospectively included infants with moderate to severe hypoxic-ischemic encephalopathy, born between May 2009 and October 2015...
July 19, 2018: Neonatology
Jing Xu, Lin-Jiang Chen, Jian Yu, Han-Jing Wang, Fan Zhang, Qiong Liu, Jing Wu
Diabetic retinopathy (DR) is a common and devastating microvascular complication of diabetes and a major cause of acquired blindness in young adults. Advanced glycation end products (AGEs) accumulated under hyperglycemic conditions are thought to play an important role in the pathogenesis of DR. AGEs can exert their deleterious effects by acting directly to induce aberrant crosslinking of extracellular matrix proteins, to increase vascular stiffness, altering vascular structure and function. Moreover, AGEs binding to the receptor for AGEs (RAGE) evokes intensive intracellular signaling cascades that leading to endothelial dysfunction, elaboration of key proinflammatory cytokines and proangiogenic factors, mediating pericyte apoptosis, vascular inflammation and angiogenesis, as well as breakdown of the inner blood-retinal barrier (BRB), the end result of all these events is damage to the neural and vascular components of the retina...
July 19, 2018: Cellular Physiology and Biochemistry
Sangkyu Kim, S Michal Jazwinski
The gut microbiota shows a wide inter-individual variation, but its within-individual variation is relatively stable over time. A functional core microbiome, provided by abundant bacterial taxa, seems to be common to various human hosts regardless of their gender, geographic location, and age. With advancing chronological age, the gut microbiota becomes more diverse and variable. However, when measures of biological age are used with adjustment for chronological age, overall richness decreases, while a certain group of bacteria associated with frailty increases...
July 19, 2018: Gerontology
Tarek Gharib, Ahmed Mohey, Abdallah Fathi, Mohamed Alhefnawy, Hisham Alazaby, Amr Eldakhakhny
OBJECTIVE: To compare the efficacy and safety of silodosin against tamsulosin as medical expulsion therapeutic agent in stone lower 1/3rd ureter. PATIENTS AND METHODS: One hundred fifty patients divided equally into 2 groups I and II received silodosin 8 mg and tamsulosin 0.4 mg respectively. Patients aged 18 years or older having single unilateral stone 10 mm or less were included in the study. Patients with bilateral or multiple stones, marked hydronephrosis, previous open or endoscopic surgery and having urinary infection were excluded...
July 19, 2018: Urologia Internationalis
Rasha Khatib, Yurany A Arevalo, Mark A Berendsen, Shyam Prabhakaran, Mark D Huffman
AIMS: We performed a systematic review to evaluate stroke presentation, evaluation, management, and outcomes among studies conducted in low- and middle-income countries (LMIC). METHODS: We searched MEDLINE (Ovid), Embase (Elsevier), and the Global Health (EBSCOhost) databases between January 2005 and June 2017 for studies conducted in LMICs defined by the World Bank. We pooled prevalence estimates using an inverse-variance weighting method and stratified by the country income group...
July 19, 2018: Neuroepidemiology
Guangming Wang, Fangce Wang, Jie Ren, Yue Qiu, Wenjun Zhang, Shane Gao, Danjing Yang, Zhigang Wang, Aibin Liang, Zhengliang Gao, Jun Xu
BACKGROUND/AIMS: Alternative splicing and DNA damage exhibit cross-regulation, with not only DNA damage inducing changes in alternative splicing, but alternative splicing itself possibly modulating the DNA damage response (DDR). Sirt1, a prominent anti-aging player, plays pivotal roles in the DDR. However, few studies have examined alternative splicing with DNA damage in neural stem cells (NSCs) and, in essence, nothing is known about whether SIRT1 regulates alternative splicing. Hence, we investigated the potential involvement of Sirt1-mediated alternative splicing in the NSC DDR...
July 19, 2018: Cellular Physiology and Biochemistry
Piotr Kocełak, Aleksander Owczarek, Maria Bożentowicz-Wikarek, Aniceta Brzozowska, Małgorzata Mossakowska, Tomasz Grodzicki, Andrzej Więcek, Jerzy Chudek, Magdalena Olszanecka-Glinianowicz
PURPOSE: The aim of the study was to assess plasma RBP4 concentration in elderly subjects in relation to nutritional status and kidney function in the population of the PolSenior Study. MATERIAL AND METHODS: We assessed RBP4, glucose, insulin, albumin, lipid profile, C-reactive protein, (hsCRP) and creatinine concentrations in 2614 PolSenior Study participants (1235 women and 1379 men). The study group was divided based on BMI and HOMA-IR values, and the occurrence of diabetes...
July 16, 2018: Advances in Medical Sciences
Sara Leitão, Vera J C Mc Carthy, Birgit A Greiner
BACKGROUND/AIMS: Health and Safety Practitioners (HSPs), as frontline professionals advocating for health and safety (HS) working conditions, have crucial roles for the wellbeing of employees. However, research studying HSPs psychosocial working conditions - i.e. job demands, control and support (JDCS) -, safety climate (SC) and their impact on HSPs health and wellbeing is scarce. This novel study aims to examine the link of JDCS and SC with HSPs' health, wellbeing and efficacy. METHODS: A web-survey was completed by 879 HSPs, members of the Institution of Occupational Safety and Health (IOSH) in Ireland and the UK...
July 16, 2018: Accident; Analysis and Prevention
Jaedon P Avey, Lisa G Dirks, Denise A Dillard, Spero M Manson, Melissa Merrick, Julia J Smith, Guilford C Prickette, Sonda Tetpon, Donna Galbreath, Brianna Triplett, Renee F Robinson
BACKGROUND: Depression remains the second leading cause of disability worldwide. Symptoms of depression are expressed and experienced differently across cultural groups, impacting treatment decisions. Patient preferences predict service utilization, treatment selection and persistence, as well as health outcomes for medical and behavioral health conditions, including depression. We identified depression management preferences of Alaska Native and American Indian (AN/AI) people who receive care within a comprehensive, integrated, tribally owned and operated healthcare facility in Anchorage, Alaska...
June 7, 2018: Journal of Affective Disorders
Daisuke Nishi, Ryoko Susukida, Kentaro Usuda, Ramin Mojtabai, Yoshio Yamanouchi
BACKGROUND: Little is known regarding trends of psychological distress and use of mental health services in Japan during recent years. METHODS: This study examined trends in severe and moderate psychological distress and the use of mental health services among adults (≥18 years old), using the Comprehensive Survey of Living Conditions in Japan from 2007, 2010, 2013, and 2016 (Total N = 2,159,005, all survey years combined). We defined a score of ≥13 on Kessler Psychological Distress Scale (K6) as severe distress and a K6 score between 5 and 12 as moderate distress...
July 10, 2018: Journal of Affective Disorders
Dennis Chan, Meredith Shafto, Rogier Kievit, Fiona Matthews, Molly Spink, Michael Valenzuela, Rik N Henson
This study tested the hypothesis that mid-life intellectual, physical, and social activities contribute to cognitive reserve (CR). Two hundred five individuals (196 with magnetic resonance imaging) aged 66-88 years from the Cambridge Centre for Ageing and Neuroscience ( were studied, with cognitive ability and structural brain health measured as fluid IQ and total gray matter volume, respectively. Mid-life activities (MAs) were measured using the Lifetime of Experiences Questionnaire. Multivariable linear regression found that MAs made a unique contribution to late-life cognitive ability independent of education, occupation, and late-life activities...
July 16, 2018: Neurobiology of Aging
Walther Parson, Mayra Eduardoff, Catarina Xavier, Barbara Bertoglio, Maria Teschler-Nicola
In 1976 human remains of seven individuals were discovered in a storage pit located within the Late Bronze Age (9th century B.C.) settlement Stillfried an der March, Austria. In contrast to the common funeral rite of cremation typical for the Urnfield culture (1300-800 B.C.) the individuals' skeletal remains were found outstandingly preserved (Figure S1). As a result, the burial was subject to various investigations, including two conflicting genealogical pedigree reconstructions, one of which was favoured by later geological fingerprinting...
July 10, 2018: Forensic Science International. Genetics
C Kelaidi, T Braun, R Arana, A Marceau-Renaut, G Lazarian, J Soret, S Cereja, R Letestu, V Eclache, D Lusina, F Baran-Marszak, L Ades, C Preudhomme, A Martin, P Fenaux, C Gardin
Immunosuppressive treatment is a disease-modifying therapy for lower-risk myelodysplastic syndromes (MDS). However, IST is relatively rarely used and long-term outcomes of patients are seldom reported. We retrospectively studied outcomes of 20 patients with lower-risk non del 5q MDS with transfusion dependency, with horse or rabbit antithymocyte globulin ± ciclosporine A, and frontline eltrombopag in two of them. IPSS-R was low, intermediate and high in 30%, 55% and 10% of the patients, respectively. Fifty-five percent of the patients had hypocellular bone marrow (BM)...
May 29, 2018: Leukemia Research
Kimberly Burnside, Kristyn Wright, Diane Poulin-Dubois
According to the social motivation theory, orienting toward social elements of the environment should be related to sociocognitive abilities, such as theory of mind (ToM), in both typically developing children and children with autism spectrum disorder. The objective of the current study was to assess whether social orienting skills predict ToM abilities in preschoolers by using two social orienting tasks (biological motion and face preference) and an implicit false belief task. A total of 38 children, aged 2-4 years, participated in this study...
July 12, 2018: Journal of Experimental Child Psychology
Friederike Erdmann, Tengfei Li, George Luta, Brenda M Giddings, Guillermo Torres Alvarado, Eva Steliarova-Foucher, Joachim Schüz, Ana M Mora
BACKGROUND: Estimating childhood cancer incidence globally is hampered by a lack of reliable data from low- and middle-income countries. Costa Rica is one of the few middle-income countries (MIC) with a long-term high quality nationwide population-based cancer registry. METHODS: Data on incident cancers in children aged under 15 years reported to the Costa Rica National Cancer Registry between 2000 and 2014 were analyzed by diagnostic group, age, sex, and geographical region and compared with incidence data for Hispanic and Non-Hispanic White (NHW) children in California, USA...
July 16, 2018: Cancer Epidemiology
Pu Wang, Xiangdong Luo, Chengqing Zhong, Lili Yang, Fuqiang Guo, Nengwei Yu
Essential tremor (ET) is one of the most common movement disorders in humans. Nevertheless, there remain several controversies surrounding ET, such as whether it is a disorder of abnormal neuronal oscillations within the tremor network. In this work, the resting-state fMRI data were collected from 17 ET patients and 17 age- and gender-matched healthy controls. First, using FOur-dimensional (spatiotemporal) Consistency of local neural Activities (FOCA) the abnormal synchronization of fMRI signals in ET patients were investigated...
July 10, 2018: Journal of the Neurological Sciences
Chloe Laurencin, Solveig Montaut, Christophe Vial, Lorraine Bernard, Sylvie Bin, Lucie Rascle, Gustavo Polo, Patrick Mertens, Teodor Danaila, Stephane Thobois
BACKGROUND: Off state toe dystonia (TD) is a symptom frequently encountered in Parkinson's disease (PD), but little is known about its evolution after subthalamic nucleus deep brain stimulation (STN-DBS). OBJECTIVE: To analyze the prevalence and the evolution of TD in PD patients candidate to STN-DBS. METHODS: Individual data of consecutive 130 PD patients who underwent STN-DBS between 2010 and 2015 were collected. RESULTS: Data were successfully collected in 95 patients...
July 12, 2018: Journal of the Neurological Sciences
Michael Bretthauer, Jeanne Mette Goderstad, Magnus Løberg, Louise Emilsson, Weimin Ye, Hans-Olov Adami, Mette Kalager
BACKGROUND: There is concern but no solid evidence that morcellation during laparoscopic or vaginal hysterectomy may cause abdominal spread and thereby impaired prognosis of incidental uterine sarcomas. OBJECTIVE: Our purpose was to compare survival among patients with uterine sarcomas who underwent hysterectomy with or without morcellation to test the hypothesis that morcellation impairs prognosis. STUDY DESIGN: We identified all women in Norway diagnosed with uterine sarcoma between 1953 and 2012 through national registries and retrieved data on surgical technique and morcellation by evaluation of patient files...
July 16, 2018: European Journal of Cancer
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