Divya R Jacob, Wilfried M Guiblet, Hulkar Mamayusupova, Mariya Shtumpf, Isabella Ciuta, Luminita Ruje, Svetlana Gretton, Milena Bikova, Clark Correa, Emily Dellow, Shivam P Agrawal, Navid Shafiei, Anastasija Drobysevskaja, Chris M Armstrong, Jonathan D G Lam, Yevhen Vainshtein, Christopher T Clarkson, Graeme J Thorn, Kai Sohn, Madapura M Pradeepa, Sankaran Chandrasekharan, Greg N Brooke, Elena Klenova, Victor B Zhurkin, Vladimir B Teif
BACKGROUND: Nucleosome repositioning in cancer is believed to cause many changes in genome organisation and gene expression. Understanding these changes is important to elucidate fundamental aspects of cancer. It is also important for medical diagnostics based on cell-free DNA (cfDNA), which originates from genomic DNA regions protected from digestion by nucleosomes. RESULTS: We have generated high-resolution nucleosome maps in paired tumour and normal tissues from the same breast cancer patients using MNase-assisted histone H3 ChIP-seq and compared them with the corresponding cfDNA from blood plasma...
April 1, 2024: Clinical Epigenetics