Bjoern Titz, Alain Sewer, Karsta Luettich, Ee Tsin Wong, Emmanuel Guedj, Catherine Nury, Thomas Schneider, Yang Xiang, Keyur Trivedi, Grégory Vuillaume, Patrice Leroy, Ansgar Büttner, Florian Martin, Nikolai V Ivanov, Patrick Vanscheeuwijck, Julia Hoeng, Manuel C Peitsch
Smoking cessation is the most effective measure for reducing the risk of smoking-related diseases. However, switching to less harmful products (modified risk tobacco products [MRTP]) can be an alternative to help reduce the risk for adult smokers who would otherwise continue to smoke. In an 18-month chronic carcinogenicity/toxicity study in A/J mice (OECD Test Guideline 453), we assessed the aerosol of Tobacco Heating System 2.2 (THS 2.2), a candidate MRTP based on the heat-not-burn principle, compared with 3R4F cigarette smoke (CS)...
August 11, 2020: Toxicological Sciences: An Official Journal of the Society of Toxicology