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Hai-Bo Ding, Kai-Xiong Liu, Jie-Feng Huang, Da-Wen Wu, Jun-Ying Chen, Qing-Shi Chen
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a multicomponent disorder characterized by inflammation, representing a significant leading cause of chronic morbidity and mortality. Reports have implicated hydrogen sulfide (H2 S) in both the pathology and treatment of COPD. The present study aimed to explore the effects involved with exogenous H2 S on endoplasmic reticulum stress (ERS) and pulmonary artery endothelial cells (PAECs) in a rat model of COPD. METHODS: Rat models of COPD were successfully established by means of passive smoke exposure and intratracheal injection with lipopolysaccharide (LPS)...
June 13, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Chen Gu, Jing Wang, Mengfan Guo, Meng Sui, Hong Lu, Guangfei Liu
Tetrabromobisphenol A (TBBPA) has attracted considerable attention due to its ubiquitous presence in different environmental compartments worldwide. However, information on its aerobic biodegradability in coastal environments remains unknown. Here, the aerobic biodegradation of TBBPA using a Pseudoalteromonas species commonly found in the marine environment was investigated. We found that extracellular biogenic siderophore, superoxide anion radical (O2 •- ), hydrogen peroxide (H2 O2 ), and hydroxyl radical (• OH) were involved in TBBPA degradation...
June 7, 2018: Water Research
Liang Shi, Jiawang Xue, Binhao Liu, Pengcheng Dong, Zhugui Wen, Zhenguo Shen, Yahua Chen
Pisolithus sp1 is an ectomycorrhizal (ECM) fungi that was chosen during a screening test of six strains of ECM fungi due to its ability to tolerate and remove hexavalent chromium (Cr(VI)). The physiological responses of Pisolithus sp1 to Cr(VI) exposure, the relationship between Pisolithus sp1 and exogenously added organic acids (EAOAs) or Na3 VO4 (H+ -ATPase inhibitor) and the ability of Pisolithus sp1 to reduce Cr(VI) in liquid culture were also investigated. Hydrogen ions (H+ ), which were produced directly by Pisolithus sp1, reduced the pH of the medium and played an important role in Cr(VI) reduction; however, Na3 VO4 significantly inhibited this process and resulted in a decrease in the Cr(VI) reduction rates...
June 13, 2018: Ecotoxicology and Environmental Safety
Qiuju Yin, Yujie Chen, Meng Zhou, Xiangsheng Jiang, Junjun Wu, Yang Sun
In order to improve the metabolism of pirfenidone (5-methyl-1-phenylpyridin-2-one, PFD), the methyl-deuterated version of pirfenidone via the substitution of hydrogen (H) at C-5 by its isotope deuterium (D, 5D-PFD) was synthesized and its photophysical properties were investigated. The negative solvatochrom was observed in absorption and fluorescence spectra with increasing solvent polarity, which implied that intermolecular charge transfer (ICT) involved n → π* transition for both of PFD and 5D-PFD...
June 7, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Jyotirmaya Behera, Akash K George, Michael J Voor, Suresh C Tyagi, Neetu Tyagi
Hydrogen sulfide (H2 S) is a novel gasotransmitter produced endogenously in mammalian cells, which works by mediating diverse physiological functions. An imbalance in H2 S metabolism is associated with defective bone homeostasis. However, it is unknown whether H2 S plays any epigenetic role in bone loss induced by hyperhomocysteinemia (HHcy). We demonstrate that diet-induced HHcy, a mouse model of metabolite induced osteoporosis, alters homocysteine metabolism by decreasing plasma levels of H2 S. Treatment with NaHS (H2 S donor), normalizes the plasma level of H2 S and further alleviates HHcy induced trabecular bone loss and mechanical strength...
June 13, 2018: Bone
Tingting Yang, Huiru Yang, Yan Fan, Bafang Li, Hu Hou
Some small bioactive molecules from food show the potential health benefits, but with poor chemical stability and bioavailability. The interactions between small molecules and gelatin were investigated. Fluorescence experiments demonstrated that the bimolecular quenching constants (kq ) of complexes (gelatin-quercetin, gelatin-curcumin, gelatin-epigallocatechin gallate, gelatin-folic acid) were 3.7 × 1012  L·mol-1 ·s-1 , 1.4 × 1012  L·mol-1 ·s-1 , 2.7 × 1012  L·mol-1 ·s-1 and 8.5 × 1012  L·mol-1 ·s-1 , indicating that fluorescence quenching did not arise from a dynamical mechanism, but from gelatin-small molecules binding...
June 13, 2018: International Journal of Biological Macromolecules
Nihong Guo, Cailian Wang, Chao Shang, Xue You, Liuyang Zhang, Wenbin Liu
Controlling the activity of tyrosinase, which plays an important role in melanin synthesis, is essential endeavor in the field of medicine, food, cosmetics, and agriculture. Baicalein is a widely available inhibitor of tyrosinase. The mechanism of this inhibition was studied through an integrated approach coupling enzyme kinetics, multiple types of spectroscopy and computational simulation. Baicalein conspicuously inhibited the diphenolase activity with an IC50 value of 0.11 mM. The inhibtion kinetics indicated that baicalein was a mix-type tight binding inhibitor with a Ki of 0...
June 13, 2018: International Journal of Biological Macromolecules
Yuanyuan Zhang, Peiyu Lu, Qinghua Sun, Tao Li, Lanjie Zhao, Xin Gao, Fanye Wang, Junhong Liu
A novel method to synthesize poly(ε-caprolactone) (PCL) through a three-step, lipase-mediated chemo-enzymatic reaction from cyclohexanone using an immobilized lipase from Trichosporon laibacchii (T. laibacchii) CBS5791 was developed. The immobilized preparation with 1280 U· g-1 used here was obtained by a method of purification and in situ immobilization where the crude intracellular lipase (cell homogenate) was subjected to partial purification by an aqueous two-phase system (ATPS) consisting of 12% (w/w) polyethylene glycol (PEG) 4000 and 13% (w/w) potassium phosphate (K2 HPO4 ) and then in situ immobilization directly on diatomite from the top PEG-rich phase of ATPS...
June 13, 2018: Journal of Biotechnology
Xiaohui Niu, Zunli Mo, Xing Yang, Mingyuan Sun, Pan Zhao, Zhenliang Li, Meixuan Ouyang, Zhenyu Liu, Huhu Gao, Ruibin Guo, Nijuan Liu
β-Cyclodextrin (β-CD) possess a hydrophobic inner cavity and a hydrophilic exterior surface. They exhibit excellent inclusion properties with the guest molecules that match cavity size, and β-CD-based materials drew widespread attention in electrochemical sensors. The hydroxy groups at the edge of the cavity can form hydrogen bonds and undergo electrostatic and dipole-dipole interactions with other molecules. This review (with 109 refs.) reveals β-CD-based detection mechanisms from the viewpoint of the size/shape-fit concept, and summarizes the current state of multiple electrochemical sensors based on the use of β-CD and functionalized β-CD such as carboxymethyl-β-CD, mono-(6-ethanediamine-6-deoxy)-β-CD, hydroxypropyl-β-CD, thio-β-cyclodextrin, and others...
June 16, 2018: Mikrochimica Acta
Kenji Imai, Tomomi Kotani, Hiroyuki Tsuda, Tomoko Nakano, Takafumi Ushida, Akira Iwase, Taku Nagai, Shinya Toyokuni, Akio Suzumura, Fumitaka Kikkawa
The aim of the present study was to investigate long-term outcomes of the offspring in a lipopolysaccharide (LPS)-induced maternal immune activation (MIA) model and the effect of maternal molecular hydrogen (H2 ) administration. We have previously demonstrated in the MIA mouse model that maternal administration of H2 attenuates oxidative damage and neuroinflammation, including induced pro-inflammatory cytokines and microglial activation, in the fetal brain. Short-term memory, sociability and social novelty, and sensorimotor gating were evaluated using the Y-maze, three-chamber, and prepulse inhibition (PPI) tests, respectively, at postnatal 3 or 4 weeks...
June 15, 2018: Scientific Reports
Zhangliang Han, Fei Qi, Hui Wang, Baoxian Liu, Xiue Shen, Cheng Song, Zhiyuan Bao, Xufeng Zhao, Yangjie Xu, Dezhi Sun
The emission of volatile sulfur compounds (VSCs) causing strong odors is a major problem in municipal sewage sludge composting plants (MSSACPs). Improving the knowledge on characteristics of VSCs emission in MSAACPs is of particular significance to elimate odors, but the studies conducted on-site to identify them are scarce. To this purpose, characteristics of VSCs emission were studied on-site from a MSSACP during different ambient temperatures corresponding with seasonal variations. Results reveal that (1) the total emission of VSCs which included methyl disulfide (DMDS), methyl sulfide (DMS), carbon disulfide, methyl mercaptan, and hydrogen sulfide (H2 S) was 561...
June 12, 2018: Waste Management
Chieh Kao, Ritu Chandna, Abhijeet Ghode, Charlotte Dsouza, Mo Chen, Andreas Larsson, Siau Hoi Lim, Minjun Wang, Zhonglian Cao, Yizhun Zhu, Ganesh S Anand, Ruowen Ge
Glucose regulated protein 78 kDa (GRP78) is a recently emerged target for cancer therapy and a biomarker for cancer prognosis. Overexpression of GRP78 is observed in many types of cancers, with the cell-surface GRP78 being preferentially present in cancer cells and cancer blood vessel endothelial cells. Isthmin (ISM) is a secreted high-affinity proapoptotic protein ligand of cell-surface GRP78 that suppresses angiogenesis and tumor growth in mice. The C-terminal AMOP (adhesion-associated domain in MUC4 and other proteins) domain of ISM is critical in mediating its interaction with human umbilical vein endothelial cells (HUVECs)...
June 12, 2018: EBioMedicine
Kajorngai Thajee, Lu Wang, Kate Grudpan, Eric Bakker
Potassium ion concentration can be successfully determined volumetrically by moving the titration from a homogeneous phase to a two phase solvent system. This is because potassium can be readily complexed in a selective and thermodynamically stable manner by ionophores such as valinomycin. Previous work demonstrated the successful titration of potassium by ion-exchange into an organic phase containing valinomycin, but the sample itself served as titrant, which is not sufficiently practical for routine applications...
October 31, 2018: Analytica Chimica Acta
Jia Yuan, Difen Wang, Ying Liu, Xianjun Chen, Hailing Zhang, Feng Shen, Xu Liu, Jiangquan Fu
BACKGROUND: Several studies have recently found that oxidative stress plays a pivotal role in the pathogenesis of traumatic brain injury (TBI) and may represent a target in TBI treatment. Hydrogen-rich water was recently shown to exert neuroprotective effects in various neurological diseases through its antioxidant properties. However, the mechanisms underlying its effects in TBI are not clearly understood. The purpose of our study was to evaluate the neuroprotective role of hydrogen-rich water in rats with TBI and to elucidate the possible mechanisms underlying its effects...
August 2018: Journal of Surgical Research
Joseph A Napoli, Ondrej Marsalek, Thomas E Markland
Acid solutions exhibit a variety of complex structural and dynamical features arising from the presence of multiple interacting reactive proton defects and counterions. However, disentangling the transient structural motifs of proton defects in the water hydrogen bond network and the mechanisms for their interconversion remains a formidable challenge. Here, we use simulations treating the quantum nature of both the electrons and nuclei to show how the experimentally observed spectroscopic features and relaxation time scales can be elucidated using a physically transparent coordinate that encodes the overall asymmetry of the solvation environment of the proton defect...
June 14, 2018: Journal of Chemical Physics
John T Kelly, Martin Mayer, Adam C Kennedy, Christian Schemel, Knut R Asmis
We investigate the perchlorate anion, ClO4 - , microhydrated with up to eight water molecules using infrared photodissociation (IRPD) spectroscopy aided by density functional theory computations. The features observed in the IRPD spectra of D2 -tagged ClO4 - (H2 O)n with n = 0-8 in the O-H stretching (2800-3800 cm-1 ) and fingerprint (800-1800 cm-1 ) spectral ranges are assigned to vibrational modes of the solvent, i.e., free and hydrogen-bonded O-H stretching and H2 O bending modes, and of the solute, i.e...
June 14, 2018: Journal of Chemical Physics
A Minecka, E Kaminska, D Heczko, M Tarnacka, I Grudzka-Flak, M Bartoszek, A Zięba, R Wrzalik, W E Śmiszek-Lindert, M Dulski, K Kaminski, M Paluch
In this paper, the molecular dynamics of a series of ester derivatives of ibuprofen (IBU), in which the hydrogen atom from the hydroxyl group was substituted by the methyl, isopropyl, hexyl, and benzyl moieties, has been investigated using Broadband dielectric (BD), Nuclear magnetic resonance (NMR), and Raman spectroscopies. We found that except for benzyl IBU (Ben-IBU), an additional process (slow mode, SM) appears in dielectric spectra in all examined compounds. It is worth noting that this relaxation process was observed for the first time in non-modified IBU (a Debye relaxation)...
June 14, 2018: Journal of Chemical Physics
Thomas S Hofer, Philippe H Hünenberger
The absolute intrinsic hydration free energy GH+ ,wat ◦ of the proton, the surface electric potential jump χwat ◦ upon entering bulk water, and the absolute redox potential VH+ ,wat ◦ of the reference hydrogen electrode are cornerstone quantities for formulating single-ion thermodynamics on absolute scales. They can be easily calculated from each other but remain fundamentally elusive, i.e., they cannot be determined experimentally without invoking some extra-thermodynamic assumption (ETA). The Born model provides a natural framework to formulate such an assumption (Born ETA), as it automatically factors out the contribution of crossing the water surface from the hydration free energy...
June 14, 2018: Journal of Chemical Physics
Fang Niu, Martin Rabe, Simantini Nayak, Andreas Erbe
The charge-dependent structure of interfacial water at the n-Ge(100)-aqueous perchlorate interface was studied by controlling the electrode potential. Specifically, a joint attenuated total reflection infrared spectroscopy and electrochemical experiment was used in 0.1M NaClO4 at pH ≈ 1-10. The germanium surface transformation to an H-terminated surface followed the thermodynamic Nernstian pH dependence and was observed throughout the entire pH range. A singular value decomposition-based spectra deconvolution technique coupled to a sigmoidal transition model for the potential dependence of the main components in the spectra shows the surface transformation to be a two-stage process...
June 14, 2018: Journal of Chemical Physics
G Camisasca, M De Marzio, M Rovere, P Gallo
We investigate using molecular dynamics simulations the dynamical and structural properties of LiCl:6H2 O aqueous solution upon supercooling. This ionic solution is a glass forming liquid of relevant interest in connection with the study of the anomalies of supercooled water. The LiCl:6H2 O solution is easily supercooled and the liquid state can be maintained over a large decreasing temperature range. We performed simulations from ambient to 200 K in order to investigate how the presence of the salt modifies the behavior of supercooled water...
June 14, 2018: Journal of Chemical Physics
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