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https://www.readbyqxmd.com/read/29224051/quercetin-protects-yeast-saccharomyces-cerevisiae-pep4-mutant-from-oxidative-and-apoptotic-stress-and-extends-chronological-lifespan
#1
Phaniendra Alugoju, Sudharshan Setra Janardhanshetty, Subasri Subaramanian, Latha Periyasamy, Madhu Dyavaiah
The yeast Saccharomyces cerevisiae PEP4 gene encodes vacuolar endopeptidase proteinase A (Pep4p), which is a homolog of the human CTSD gene that encodes cathepsin D. Mutation of CTSD gene in human resulted in a number of neurodegenerative diseases. In this study, we have shown that yeast pep4 mutant cells are highly sensitive to oxidative and apoptotic stress induced by hydrogen peroxide and acetic acid, respectively. pep4∆ cells also showed accumulation of reactive oxygen species (ROS), apoptotic markers, and reduced chronological lifespan...
December 9, 2017: Current Microbiology
https://www.readbyqxmd.com/read/29223917/molecular-dynamics-simulations-suggest-changes-in-electrostatic-interactions-as-a-potential-mechanism-through-which-serine-phosphorylation-inhibits-dna-polymerase-%C3%AE-s-activity
#2
Dirar Homouz, Kwee Hong Joyce-Tan, Mohd Shahir Shamsir, Ibrahim M Moustafa, Haitham Idriss
DNA polymerase β is a 39kDa enzyme that is a major component of Base Excision Repair in human cells. The enzyme comprises two major domains, a 31kDa domain responsible for the polymerase activity and an 8kDa domain, which bind ssDNA and has a deoxyribose phosphate (dRP) lyase activity. DNA polymerase β was shown to be phosphorylated in vitro with protein kinase C (PKC) at serines 44 and 55 (S44 and S55), resulting in loss of its polymerase enzymic activity, but not its ability to bind ssDNA. In this study, we investigate the potential phosphorylation-induced structural changes for DNA polymerase β using molecular dynamics...
November 7, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29223865/prevention-of-ischemia-induced-hearing-loss-by-intravenous-administration-of-hydrogen-rich-saline-in-gerbil
#3
Hideo Ogawa, Masahiro Okada, Masachika Shudou, Kiyofumi Gyo, Naohito Hatoa
OBJECTIVE: Hydrogen-rich water, which is a potent antioxidant agent, was investigated for its protective effects against ischemic damage of the cochlea in gerbils. METHODS: The animals were subjected to transient cochlear ischemia by occluding the bilateral vertebral arteries for l5minutes. Five milliliters of hydrogen-rich saline was then intravenously administered immediately after the insult. Saline without hydrogen was used as a control. Effects of hydrogen were evaluated using the auditory brainstem response (ABR) and histological studies of the inner ear...
December 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29223807/design-synthesis-and-biological-evaluation-of-deuterated-phenylpropionic-acid-derivatives-as-potent-and-long-acting-free-fatty-acid-receptor-1-agonists
#4
Zheng Li, Chunxia Liu, Xue Xu, Wei Shi, Huilan Li, Yuxuan Dai, Xingguang Cai, Wenlong Huang, Hai Qian
The free fatty acid receptor 1 (FFA1) is a potential target due to its function in enhancement of glucose-stimulated insulin secretion. Takeda's compound 1 has robustly in vitro activity for FFA1, but it has been suffered from poor pharmacokinetic (PK) profiles because the phenylpropanoic acid is vulnerable to β-oxidation. To identify orally available agonists, we tried to interdict the metabolically labile group by incorporating two deuterium atoms at the α-position of phenylpropionic acid. Interestingly, the differences of physicochemical properties between hydrogen and deuterium are quite small, but there are many differences in the structure-activity relationship between phenylpropionic acid series and present deuterated series...
December 5, 2017: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29223513/study-of-first-electronic-transition-and-hydrogen-bonding-state-of-ultra-thin-water-layer-of-nanometer-thickness-on-an-%C3%AE-alumina-surface-by-far-ultraviolet-spectroscopy
#5
Takeyoshi Goto, Tomoya Kinugasa
The first electronic transition (A˜←X˜) and the hydrogen bonding state of an ultra-thin water layer of nanometer thickness between two α-alumina surfaces (0.5-20nm) were studied using far-ultraviolet (FUV) spectroscopy in the wavelength range 140-180nm. The ultra-thin water layer of nanometer thickness was prepared by squeezing a water droplet (~1μL) between a highly polished α-alumina prism and an α-alumina plate using a high pressure clamp (~4.7MPa), and the FUV spectra of the water layer at different thicknesses were measured using the attenuated total reflection method...
December 6, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29223116/effect-of-pre-pyrolysis-mode-on-simultaneous-introduction-of-nitrogen-oxygen-containing-functional-groups-into-the-structure-of-bagasse-based-mesoporous-carbon-and-its-influence-on-cu-ii-adsorption
#6
Zeqing Wan, Kunquan Li
A convenient effective microwave pre-pyrolysis treatment to synthesize biomass-based mesoporous carbon with higher nitrogen/oxygen-chelating adsorption for Cu(II) is reported here, in which phosphoric acid impregnated bagasse was used as a microwave absorber and porogen. For comparison, conventional electric-heating pyrolyzed carbon was prepared and doped with nitrogen/oxygen groups. Nitrogen adsorption, scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy (XPS) and batch adsorption were employed to investigate the effects of the two pre-pyrolysis modes on the sample physicochemical and Cu(II) adsorptive properties...
December 1, 2017: Chemosphere
https://www.readbyqxmd.com/read/29223068/comprehensive-analysis-and-transcript-profiling-of-arabidopsis-thaliana-and-oryza-sativa-catalase-gene-family-suggests-their-specific-roles-in-development-and-stress-responses
#7
Nazmir Binta Alam, Ajit Ghosh
Stress induces the generation of Reactive Oxygen Species (ROS) that ultimately hampers the growth, development, and productivity of the plant. As an antioxidant enzyme, catalase converts hydrogen peroxide to water and keeps ROS level down to protect cells from stress-induced apoptosis. Here, a genome-wide analysis of catalase gene family has been performed in two model plants- Arabidopsis thaliana and Oryza sativa. Both Arabidopsis and rice has a small family of three and four genes, respectively; that code for seven proteins each...
December 1, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29223024/genomic-integration-and-expression-of-the-aggregatibacter-actinomycetemcomitans-catalase-gene-in-aggregatibacter-aphrophilus
#8
Yuting Alice Yang, Ya-An Cheng, Casey Chen
OBJECTIVE: To test the hypothesis that virulence genes of Aggregatibacter actinomycetemcomitans can be expressed and confer fitness advantages in the closely related Aggregatibacter aphrophilus. DESIGN: Clinical isolates of A. aphrophilus were screened for natural competence with marked genomic DNA from A. actinomycetemcomitans and A. aphrophilus. The gene katA of A. actinomycetemcomitans D7S-1 and its flanking regions were constructed and inserted into a comparable locus in the genome of a naturally competent A...
December 5, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/29223021/pre-treatment-of-soybean-plants-with-calcium-stimulates-ros-responses-and-mitigates-infection-by-sclerotinia-sclerotiorum
#9
Arbia Arfaoui, Abdelbasset El Hadrami, Fouad Daayf
Considering the high incidence of white mold caused by Sclerotinia sclerotiorum in a variety of field crops and vegetables, different control strategies are needed to keep the disease under economical threshold. This study assessed the effect of foliar application of a calcium formulation on disease symptoms, oxalic acid production, and on the oxidative stress metabolism in soybean plants inoculated with each of two isolates of the pathogen that have contrasting aggressiveness (HA, highly-aggressive versus WA, weakly-aggressive)...
November 26, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29222974/cold-atmospheric-plasma-cap-a-novel-physicochemical-source-induces-neural-differentiation-through-cross-talk-between-the-specific-rons-cascade-and-trk-ras-erk-signaling-pathway
#10
Ja-Young Jang, Young June Hong, Junsup Lim, Jin Sung Choi, Eun Ha Choi, Seongman Kang, Hyangshuk Rhim
Plasma, formed by ionization of gas molecules or atoms, is the most abundant form of matter and consists of highly reactive physicochemical species. In the physics and chemistry fields, plasma has been extensively studied; however, the exact action mechanisms of plasma on biological systems, including cells and humans, are not well known. Recent evidence suggests that cold atmospheric plasma (CAP), which refers to plasma used in the biomedical field, may regulate diverse cellular processes, including neural differentiation...
November 30, 2017: Biomaterials
https://www.readbyqxmd.com/read/29222946/triheptanoin-protects-against-status-epilepticus-induced-hippocampal-mitochondrial-dysfunctions-oxidative-stress-and-neuronal-degeneration
#11
Kah Ni Tan, David Simmons, Catalina Carrasco-Pozo, Karin Borges
Triheptanoin, the triglyceride of heptanoate, is anaplerotic (refills deficient tricarboxylic acid cycle intermediates) via the propionyl-CoA carboxylase (PCC) pathway. It has been shown to be neuroprotective and anticonvulsant in several models of neurological disorders. Here, we investigated the effects of triheptanoin against changes of hippocampal mitochondrial functions, oxidative stress and cell death induced by pilocarpine-induced status epilepticus (SE) in mice. Ten days of triheptanoin pre-treatment did not protect against SE, but it preserved hippocampal mitochondrial functions including state 2, state 3 ADP, state 3 uncoupled respiration, respiration linked to ATP synthesis along with the activities of pyruvate dehydrogenase complex and oxoglutarate dehydrogenase complex 24 h post-SE...
December 9, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29222879/prevalence-cause-and-diagnosis-of-lactose-intolerance-in-children-aged-1-5-years-a-systematic-review-of-1995-2015-literature
#12
Louise Harvey, Thomas Ludwig, Alice Qian Hou, Quak Seng Hock, Michelle Ln Tan, Seksit Osatakul, Jacques Bindels, Leilani Muhardi
BACKGROUND AND OBJECTIVES: To assess the prevalence, etiology, diagnosis of primary and secondary lactose intolerance (LI), including age of onset, among children 1-5 years of age. Suspected/perceived lactose intolerance can lead to dietary restrictions which may increase risk of future health issues. METHODS AND STUDY DESIGN: MEDLINE, CAB Abstract, and Embase were searched for articles published from January 1995-June 2015 related to lactose intolerance in young children...
2018: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29222836/biochemical-and-structural-insights-into-a-thermostable-cellobiohydrolase-from-myceliophthora-thermophila
#13
Marco Antonio Seiki Kadowaki, Paula Higasi, Mariana Ortiz de Godoy, Rolf A Prade, Igor Polikarpov
Cellobiohydrolases hydrolyze cellulose, a linear polymer with glucose monomers linked exclusively by β-1,4 glycosidic linkages. The widespread hydrogen bonding network tethers individual cellulose polymers forming crystalline cellulose, which prevent the access of hydrolytic enzymes and water molecules. The most abundant enzyme secreted by Myceliophthora thermophila M77 in response to the presence of biomass is the cellobiohydrolase MtCel7A, which is composed by a GH7-catalytic domain (CD), a linker and a CBM1-type carbohydrate binding module...
December 8, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29222020/synthesis-of-protocatechuic-acid-grafted-chitosan-copolymer-structure-characterization-and-in-vitro-neuroprotective-potential
#14
Chao Xu, Shui Guan, Bo Wang, Shuping Wang, Yuxin Wang, Changkai Sun, Xuehu Ma, Tianqing Liu
Excessive free radicals can cause oxidative damage to human tissues, which results in a variety of diseases. Therefore, the development of antioxidant materials is one of the great projects in biomedical field. In this work, antioxidant protocatechuic acid (PCA) monomers were grafted onto chitosan (CS) backbones to develop a PCA grafted chitosan (PCA-g-CS) antioxidant copolymer via the method of free radical-induced grafting reaction. The formation of covalent bonds between PCA and CS were confirmed by FTIR, 1H NMR, XRD and UV-Vis...
December 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29221935/effects-of-intermolecular-interactions-on-absorption-intensities-of-the-fundamental-and-the-first-second-and-third-overtones-of-oh-stretching-vibrations-of-methanol-and-t-butanol%C3%A2-d9-in-n-hexane-studied-by-visible-near-infrared-infrared-spectroscopy
#15
Yusuke Morisawa, Arisa Suga
Visible (Vis), near-infrared (NIR) and IR spectra in the 15,600-2500cm-1 region were measured for methanol, methanol-d3, and t-butanol-d9 in n-hexane to investigate effects of intermolecular interaction on absorption intensities of the fundamental and the first, second, and third overtones of their OH stretching vibrations. The relative area intensities of OH stretching bands of free and hydrogen-bonded species were plotted versus the vibrational quantum number using logarithm plots (V=1-4) for 0.5M methanol, 0...
November 28, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29221868/influence-of-hydrogen-bond-accepting-ability-of-anions-on-the-adsorption-performance-of-ionic-liquid-surface-molecularly-imprinted-polymers
#16
Guifen Zhu, Xia Gao, Xiaolong Wang, Jianji Wang, Jing Fan
To illuminate the influence mechanism of anionic structure of ionic liquids (ILs) on the adsorption performance of surface molecularly imprinted polymers (MIPs), in this work, six newly designed MIPs were prepared on the surface of amino-poly(styrene-divinylbenzene) particles by using imidazolium ILs with the same cation [C4mim]+ but different anions (Cl, CH3SO3, PF6, BF4, C4F7O2, C4F9SO3) as template molecules, methacrylic acid as functional monomer, and ethylene dimethacrylate as cross-linker. The resulting MIP materials were characterized by IR and SEM, and the influence of hydrogen bond accepting ability of anions on the adsorption performance of the MIPs for the ILs was investigated in acetonitrile...
November 26, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29221380/halogen-bonding-properties-of-4-iodopyrazole-and-4-bromopyrazole-explored-by-rotational-spectroscopy-and-ab-initio-calculations
#17
Graham A Cooper, Chris Medcraft, Josh D Littlefair, Thomas J Penfold, Nicholas R Walker
The combination of halogen- and hydrogen-bonding capabilities possessed by 4-bromopyrazole and 4-iodopyrazole has led to them being described as "magic bullets" for biochemical structure determination. Laser vaporisation was used to introduce each of these 4-halopyrazoles into an argon gas sample undergoing supersonic expansion prior to the recording of the rotational spectra of these molecules by chirped-pulse Fourier transform microwave spectroscopy. Data were obtained for four isotopologues of 4-bromopyrazole and two isotopologues of 4-iodopyrazole...
December 7, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29221146/swertiajaponin-inhibits-skin-pigmentation-by-dual-mechanisms-to-suppress-tyrosinase
#18
Bonggi Lee, Kyoung Mi Moon, Bong-Seon Lee, Ju-Hye Yang, Kwang Il Park, Won-Kyung Cho, Jin Yeul Ma
Many skin-whitening compounds target tyrosinase because it catalyzes two rate-limiting steps in melanin synthesis. Although many tyrosinase inhibitors are currently available for a skin-whitening purpose, undesirable adverse effects are also reported. Thus, numerous efforts have been made to develop safer tyrosinase inhibitors from natural products. In line with this, we tested fifty flavonoids, a group of naturally occurring antioxidants and metal chelators, and screened swertiajaponin as the strongest tyrosinase inhibitor in cell-free experiments...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29221138/gas-signaling-molecule-hydrogen-sulfide-attenuates-doxorubicin-induced-dilated-cardiomyopathy
#19
Zongliang Yu, Wei Zhang, Mengyao Zhang, Mengchao Jin, Weiting Xu, Xiang Zhou
Increasing evidence has revealed that hydrogen sulfide (H2S) has beneficial effects in the treatment of various cardiovascular diseases. However, whether H2S can attenuate the development of dilated cardiomyopathy (DCM) remains unclear. In this study, we generated a rat model of DCM induced by doxorubicin and investigated the protective effects of H2S against DCM. Cardiac structure and function were analyzed by two-dimensional echocardiography. Oxidative stress was evaluated by measuring malondialdehyde, superoxide dismutase, glutathione peroxidase and reactive oxygen species...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29221091/raman-lidar-for-hydrogen-gas-concentration-monitoring-and-future-radioactive-waste-management
#20
Anasthase Liméry, Nicolas Cézard, Didier Fleury, Didier Goular, Christophe Planchat, Johan Bertrand, Alain Hauchecorne
A multi-channel Raman lidar has been developed, allowing for the first time simultaneous and high-resolution profiling of hydrogen gas and water vapor. The lidar measures vibrational Raman scattering in the UV (355 nm) domain. It works in a high-bandwidth photon counting regime using fast SiPM detectors and takes into account the spectral overlap between hydrogen and water vapor Raman spectra. Measurement of concentration profiles of H2 and H2O are demonstrated along a 5-meter-long open gas cell with 1-meter resolution at 85 meters...
November 27, 2017: Optics Express
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