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https://www.readbyqxmd.com/read/29343477/role-of-asic3-nav1-7-and-nav1-8-in-electroacupuncture-induced-analgesia-in-a-mouse-model-of-fibromyalgia-pain
#1
Liang-Ta Yen, Yu-Chan Hsu, Jaung-Geng Lin, Ching-Liang Hsieh, Yi-Wen Lin
BACKGROUND: The mechanisms underlying fibromyalgia (FM) pain are not understood. The US Food and Drug Administration has recommended three drugs for treating FM-namely, pregabalin, duloxetine and milnacipran; however, these medications are associated with severe side effects. OBJECTIVE: To create a mouse model of FM pain using dual injections of acidic saline to cause mechanical hyperalgesia and test whether ASIC3, Nav1.7 and Nav1.8 are involved in this process and whether electroacupuncture (EA) can reverse these phenomena...
January 17, 2018: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/29340774/-exercise-to-me-is-a-scary-word-perceptions-of-fatigue-sleep-dysfunction-and-exercise-in-people-with-fibromyalgia-syndrome-a-focus-group-study
#2
D Russell, I C Álvarez Gallardo, I Wilson, C M Hughes, G W Davison, B Sañudo, J G McVeigh
Fibromyalgia syndrome (FMS) is a common and complex chronic pain condition. Exercise is recommended in the management of the FMS; however, people with FMS often find exercise exacerbates their condition and causes overwhelming fatigue. The objective of this study was to explore the perceptions of fatigue and sleep dysfunction, and exercise in people with FMS. Three, 60-90 min focus groups were conducted with people with FMS (n = 14). Participants were recruited from patient support groups who had experienced therapeutic exercise in the management of their condition...
January 16, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29340257/symmetrical-drug-related-intertriginous-and-flexural-exanthema-induced-by-doxycycline
#3
David G Li, Cristina Thomas, Gil S Weintraub, Arash Mostaghimi
Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) is a cutaneous drug reaction characterized by erythema over the buttocks, thighs, groin, and flexural regions most commonly associated with the use of beta-lactam antibiotics. Although the exact pathophysiology of this disease remains unknown, it is theorized to be the result of a delayed hypersensitivity response presenting as a cutaneous eruption days to weeks after exposure to the drug. The treatment involves discontinuation of the suspected medication, symptomatic control of pruritus, and topical steroid therapy...
November 10, 2017: Curēus
https://www.readbyqxmd.com/read/29338150/the-role-of-cannabinoids-in-pain-control-the-good-the-bad-and-the-ugly
#4
Joseph V Pergolizzi, Jo Ann Lequang, Robert Taylor, Robert B Raffa, Daniel Colucci
Cannabinoids appear to possess many potential medical uses, which may extend to pain control. A narrative review of the literature has found a variety of studies testing botanical and synthetic cannabinoids in different pain syndromes (acute pain, cancer pain, chronic noncancer pain, fibromyalgia pain, migraine, neuropathic pain, visceral pain, and others). Results from these studies are mixed; cannabinoids appear to be most effective in controlling neuropathic pain, allodynia, medication-rebound headache, and chronic noncancer pain, but do not seem to offer any advantage over nonopioid analgesics for acute pain...
January 16, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29326058/sleep-architecture-is-altered-in-the-reserpine-induced-fibromyalgia-model-in-ovariectomized-rats
#5
Alberto Hernandez-Leon, Alonso Fernández-Guasti, Adrián Martínez, Francisco Pellicer, María Eva González-Trujano
Fibromyalgia (FM) is a musculoskeletal chronic pain syndrome with various concomitant symptoms like sleep disorders. FM patients are mainly women and menopause might play an important role in the altered processing of somatosensory information. Adverse effects and moderated efficacy of drugs promote treatment discontinuation by patients. Animal models of FM report pain and depression-like behaviors, but none of them have explored sleep disturbance as possible marker in the preclinic diagnostic. The aim of this study was to investigate alterations of the sleep architecture in the reserpine (RES)-induced FM model in ovarectomized (OVX) rats...
January 8, 2018: Behavioural Brain Research
https://www.readbyqxmd.com/read/29321621/functional-brain-network-mechanism-of-hypersensitivity-in-chronic-pain
#6
UnCheol Lee, Minkyung Kim, KyoungEun Lee, Chelsea M Kaplan, Daniel J Clauw, Seunghwan Kim, George A Mashour, Richard E Harris
Fibromyalgia (FM) is a chronic widespread pain condition characterized by augmented multi-modal sensory sensitivity. Although the mechanisms underlying this sensitivity are thought to involve an imbalance in excitatory and inhibitory activity throughout the brain, the underlying neural network properties associated with hypersensitivity to pain stimuli are largely unknown. In network science, explosive synchronization (ES) was introduced as a mechanism of hypersensitivity in diverse biological and physical systems that display explosive and global propagations with small perturbations...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29319461/hypnosis-is-more-effective-than-clinical-interviews
#7
Francisco Xavier De Almeida-Marques, José Sánchez-Blanco, Francisco Javier Cano-García
To determine whether hypnosis is more effective than conventional interviewing to find traumatic life events in patients with fibromyalgia, we carried out a within-subject experimental design with complete intragroup counterbalancing. Thirty-two women under care in a public primary care center gave 2 identical interviews, with an interval of 3 months, in which the occurrence of traumatic life events was explored, once in a state of wakefulness and once in a state of hypnosis. The state of consciousness was evaluated using 3 measures: bispectral index, skin conductance level, and pain intensity...
January 2018: International Journal of Clinical and Experimental Hypnosis
https://www.readbyqxmd.com/read/29318645/endometriosis-increased-the-risk-of-bladder-pain-syndrome-interstitial-cystitis-a-population-based-study
#8
Chia-Chang Wu, Shiu-Dong Chung, Herng-Ching Lin
OBJECTIVE: Previous studies have suggested an association between bladder pain syndrome/interstitial cystitis (BPS/IC) and endometriosis. However, no nation-wide population study has yet reported an association between them. In this study, we examined the risk of BPS/IC among subjects with endometriosis during a 3-year follow-up in Taiwan using a population-based dataset. STUDY DESIGN: This study comprised 9191 subjects with endometriosis, and 27 573 subjects randomly selected as controls...
January 10, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29318420/severity-of-symptoms-persists-for-decades-in-fibromyalgia-a-26-year-follow-up-study
#9
Risto Isomeri, Marja Mikkelsson, Markku Partinen, Markku J Kauppi
The aim of this study is to find out the outcome of 28 patients who got the diagnosis of primary fibromyalgia (pFM) 26 years ago. In 1986, 56 patients with widespread pain were examined and filled in a base questionnaire (BQ). Of them, 42 fulfilled the Yunus criteria for pFM. Twenty-six years later, addresses of 38 patients were found, and an extensive follow-up questionnaire (FupQ) was mailed to them. Of them, 28 (74%) answered the FupQ. This included nine identical questions with the BQ and questions concerning changes in their symptoms and quality of life (Qol)...
January 9, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29317060/fibromyalgia-and-unexplained-widespread-pain-the-idiopathic-cerebrospinal-pressure-dysregulation-hypothesis
#10
M Hulens, W Dankaerts, I Stalmans, A Somers, G Vansant, R Rasschaert, F Bruyninckx
Fibromyalgia (FM) is a debilitating, widespread pain disorder that is assumed to originate from inappropriate pain processing in the central nervous system. Psychological and behavioral factors are both believed to underlie the pathogenesis and complicate the treatment. This hypothesis, however, has not yet been sufficiently supported by scientific evidence and accumulating evidence supports a peripheral neurological origin of the symptoms. We postulate that FM and several unexplained widespread pain syndromes are caused by chronic postural idiopathic cerebrospinal hypertension...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29316709/screaming-body-and-silent-healthcare-providers-a-case-study-with-a-childhood-sexual-abuse-survivor
#11
REVIEW
Sigrun Sigurdardottir, Sigridur Halldorsdottir
Stressful early life experiences cause immune dysregulation across the lifespan. Despite the fact that studies have identified childhood sexual abuse (CSA) survivors as a particularly vulnerable group, only a few attempts have been made to study their lived-experience of the physical health consequences of CSA. The aim of this study was to explore a female CSA survivor's lived-experience of the physical health consequences of CSA and how she experienced the reactions of healthcare providers. Seven interviews were conducted with this 40-year-old woman, Anne, using a phenomenological research approach...
January 8, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29315426/an-e-learning-module-on-chronic-low-back-pain-in-older-adults-effect-on-medical-resident-attitudes-confidence-knowledge-and-clinical-skills
#12
Zachary G Jacobs, D Michael Elnicki, Subashan Perera, Debra K Weiner
Objective: To determine 1) the feasibility of implementing an e-learning module on chronic low back pain (CLBP) in an older adult into an existing internal medicine residency curriculum and 2) the impact of this module on resident attitudes, confidence, knowledge, and clinical skills relating to CLBP. Methods: Participants were assigned to complete either the online module (N = 73) or the Yale Office-based curriculum on CLBP (N = 70). Attitudes, confidence, and knowledge were evaluated pre- and postintervention via survey...
January 5, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29310454/determinants-of-representational-and-behavioral-hyperactivity-in-patients-with-fibromyalgia-syndrome
#13
Jacques Grisart, Nathalie Scaillet, Marie Michaux, Etienne Masquelier, Carole Fantini, Olivier Luminet
Fibromyalgia is associated with a premorbid hyperactivity. This study examines how contextual and personality factors contribute to premorbid hyperactivity. A total of 45 patients completed questionnaires. The results show that the number of children and the basic bodily needs neglect (and their interaction) explain nearly 50 percent of the variance of hyperactivity. The neglect toward bodily needs completely mediates the relation between self-oriented perfectionism and hyperactivity. This study suggests that hyperactivity itself would not have a pathological value, but that the neglect of basic bodily needs would represent a vulnerability factor in a hyperactive premorbid lifestyle in fibromyalgia patients...
January 1, 2018: Journal of Health Psychology
https://www.readbyqxmd.com/read/29310453/the-relationship-between-sleep-quality-and-fibromyalgia-symptoms
#14
Alexandro Andrade, Guilherme Torres Vilarino, Sofia Mendes Sieczkowska, Danilo Reis Coimbra, Guilherme Guimarães Bevilacqua, Ricardo de Azevedo Klumb Steffens
This study investigated the relationship between sleep quality and fibromyalgia symptoms in 326 patients. The Pittsburgh Sleep Quality Index was used to assess the presence of sleep disorders. Multivariate analysis of variance was performed to determine the influence of fibromyalgia symptoms on sleep quality. The prevalence of sleep disorders was 92.9 percent. Patients reported generalized pain (88.3%), memory failure (78.5%), moodiness (59%), excessive anxiety (77.5%), and concentration difficulties (69...
January 1, 2018: Journal of Health Psychology
https://www.readbyqxmd.com/read/29306954/management-of-functional-somatic-syndromes-and-bodily-distress
#15
Peter Henningsen, Stephan Zipfel, Heribert Sattel, Francis Creed
Functional somatic syndromes (FSS), like irritable bowel syndrome or fibromyalgia and other symptoms reflecting bodily distress, are common in practically all areas of medicine worldwide. Diagnostic and therapeutic approaches to these symptoms and syndromes vary substantially across and within medical specialties from biomedicine to psychiatry. Patients may become frustrated with the lack of effective treatment, doctors may experience these disorders as difficult to treat, and this type of health problem forms an important component of the global burden of disease...
January 6, 2018: Psychotherapy and Psychosomatics
https://www.readbyqxmd.com/read/29306936/remote-healing-of-bipolar-disorder-eating-disorder-not-otherwise-specified-posttraumatic-stress-disorder-fibromyalgia-and-irritable-bowel-syndrome-through-lifestyle-change
#16
Kelly Brogan
This case report illustrates the relationship between gut, hormonal, and brain function in that dietary change, mindfulness interventions, and detoxification led to resolution of disabling psychiatric symptoms. In this case, a single Caucasian female resolved her symptoms of bipolar disorder (BD) including psychotic features and suicidality, posttraumatic stress disorder symptoms from childhood torture, disordered eating, fibromyalgia, and irritable bowel syndrome through lifestyle interventions. This patient survived a severe trauma history only to develop alcohol dependence, disordered eating, and depressive symptoms, which were treated with a polypharmaceutical psychiatric approach...
October 2017: Advances in Mind-body Medicine
https://www.readbyqxmd.com/read/29306226/does-fibromyalgia-have-an-effect-on-hearing-loss-in-women
#17
Zeliha Kapusuz Gencer, Özlem Balbaloğlu, Mahmut Özkırış, Levent Saydam
Background/aim: Fibromyalgia (FM) patients may have several neuroendocrine dysfunctions, resulting in a hypervigilant sensory output that may be responsible for sensorineural complaints. In this study, we evaluated the audiological findings of a cohort of female fibromyalgia patients. Materials and methods: Between 1 September 2012 and 1 June 2013, 35 female FM patients, followed by the Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Bozok University, were recruited for the study. The patients were referred to the Department of Otolaryngology for routine otolaryngological and audiological evaluations...
December 19, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/29304243/hyperexcitability-of-the-central-nervous-system-in-children-with-chronic-pain-a-systematic-review
#18
Roselien Pas, Kelly Ickmans, Sophie Van Oosterwijck, Kelly Van der Cruyssen, Anthe Foubert, Laurence Leysen, Jo Nijs, Mira Meeus
Objective: Hyperexcitability of the central nervous system plays an important role in the development and maintenance of chronic pain in adults. This knowledge has led to improved treatment strategies within this population. In children, however, research on the presence of central hyperexcitability is scarce. To further investigate this topic in children with chronic pain, there is a need for a clear literature overview. Design: Systematic review. Methods: The literature search was performed using the electronic databases PubMed and Web of Science...
January 2, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29302188/migraine-in-young-females-with-irritable-bowel-syndrome-still-a-challenge
#19
Doina Georgescu, Daniela Reisz, Camelia Vidita Gurban, Liviu Andrei Georgescu, Ioana Ionita, Oana Elena Ancusa, Daniel Lighezan
Migraine without aura is frequently reported in female patients with irritable bowel syndrome (IBS), but knowledge about the relationship between these two conditions is still lacking. This study was aimed to explore the particularities of migraine without aura in young female patients with IBS in order to establish a possible link between them. From a cohort of young female patients hospitalized with IBS in the Internal Medicine Department, 30 joined this pilot study, and they were assigned into two groups on the basis of presence or absence of migraine...
2018: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/29298077/fibromyalgia-with-gabapentin-and-osteopathic-manipulative-medicine-a-pilot-study
#20
Cynthia Marske, Natasha Bernard, Alison Palacios, Cary Wheeler, Ben Preiss, Mackenzie Brown, Saveri Bhattacharya, Gloria Klapstein
OBJECTIVES: This pilot study compares the safety and efficacy of three treatments in reducing pain and improving fibromyalgia symptoms. DESIGN: This study was an 8-week prospective, single center feasibility study. SETTING AND SUBJECTS: Forty subjects were recruited from Solano, Sonoma, and Contra Costa counties of California in 2006-2009. Subjects were aged 18-65 and met the American College of Rheumatology (ACR) 1990 criteria for fibromyalgia...
January 3, 2018: Journal of Alternative and Complementary Medicine: Research on Paradigm, Practice, and Policy
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