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Norman parathyroid

Rino Buzzola, Lilamani Romayne Kurukulasuriya, Mariana Touza, Norman S Litofsky, Stephen Brietzke, James R Sowers
BACKGROUND: Multiple endocrine neoplasia (MEN) type 1 syndrome is an uncommon inherited disorder characterized by the occurrence of tumors involving two or more endocrine glands. These tumors include pheochromocytoma, adrenal cortical and neuroendocrine tumors including (bronchopulmonary, thymic, gastric), lipomas, angiofibromas, collagenomas, and meningiomas. MEN-4 is very rare and has been characterized by the occurrence of parathyroid and anterior pituitary tumors in association with tumors of the adrenals, kidneys, and reproductive organs...
February 2016: Cardiorenal Medicine
Jigar Bhagatwala, Haidong Zhu, Samip J Parikh, De-Huang Guo, Ishita Kotak, Ying Huang, Robyn Havens, Michael Pham, Eric Afari, Susan Kim, Christopher Cutler, Norman K Pollock, Yutong Dong, Anas Raed, Yanbin Dong
BACKGROUND: A critical need exists to better understand the physiological sequel of vitamin D supplementation in obese individuals and African Americans. The aim was to comprehensively evaluate dose- and time-responses of a panel of vitamin D biomarkers to vitamin D supplements in this population. METHODS: We conducted a 16-week randomized, double-blinded, and placebo-controlled clinical trial. Seventy overweight/obese African Americans (age 13-45 years, 84 % females) with 25-hydroxyvitamin D [25(OH)D] concentrations ≤20 ng/mL were randomly assigned to receive a supervised monthly oral vitamin D3 of 18,000 IU (~600 IU/day, n = 17), 60,000 IU (~2000 IU/day, n = 18), 120,000 IU (~4000 IU/day, n = 18), or placebo (n = 17)...
2015: BMC Obesity
Johan Halse, Susan Greenspan, Felicia Cosman, Graham Ellis, Arthur Santora, Albert Leung, Norman Heyden, Suvajit Samanta, Steven Doleckyj, Elizabeth Rosenberg, Andrew E Denker
CONTEXT: MK-5442 is an orally bioavailable calcium-sensing receptor antagonist that is hypothesized to stimulate bone formation by stimulating endogenous secretion of a pulse of PTH. Earlier clinical and preclinical studies demonstrated increased bone mineral density (BMD) after treatment. OBJECTIVE: Our objective was to identify a dose of MK-5442 that produces osteoanabolic effects without excessive hypercalcemia. DESIGN AND SETTING: This was a randomized, double-blind, placebo-controlled, parallel-group trial of private or institutional practice...
November 2014: Journal of Clinical Endocrinology and Metabolism
Erin E Chambers, Mary E Lame, Jon Bardsley, Sally Hannam, Cristina Legido-Quigley, Norman Smith, Kenneth J Fountain, Eileen Collins, Elizabeth Thomas
Teriparatide, the 1-34 fragment of human parathyroid hormone, is used to treat osteoporosis patients with a high risk of fracture by stimulating new bone formation. Routinely teriparatide is quantified using radioimmunoassay however the LC-MS/MS described here has the potential to achieve greater accuracy and precision, higher specificity, and is readily implemented in routine bioanalytical laboratories. Hence a complete method combining effective sample prep with appropriate LC separation and selected reaction monitoring (SRM) MS detection was developed to selectively separate teriparatide from closely related endogenous peptides and to reduce interferences...
November 1, 2013: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Ryan S Jackson, James T May, James Norman, Tapan A Padhya
No abstract text is available yet for this article.
November 2013: Otolaryngology—Head and Neck Surgery
Adeera Levin, Claudio Rigatto, Barrett Brendan, François Madore, Norman Muirhead, Daniel Holmes, Catherine M Clase, Mila Tang, Ognjenka Djurdjev
BACKGROUND: The Canadian Study of Prediction of Death, Dialysis and Interim Cardiovascular Events (CanPREDDICT) is a large, prospective, pan-Canadian, cohort study designed to improve our understanding of determinants of renal and cardiovascular (CV) disease progression in patients with chronic kidney disease (CKD). The primary objective is to clarify the associations between traditional and newer biomarkers in the prediction of specific renal and CV events, and of death in patients with CKD managed by nephrologists...
2013: BMC Nephrology
Rafael Lozano, Mohsen Naghavi, Kyle Foreman, Stephen Lim, Kenji Shibuya, Victor Aboyans, Jerry Abraham, Timothy Adair, Rakesh Aggarwal, Stephanie Y Ahn, Miriam Alvarado, H Ross Anderson, Laurie M Anderson, Kathryn G Andrews, Charles Atkinson, Larry M Baddour, Suzanne Barker-Collo, David H Bartels, Michelle L Bell, Emelia J Benjamin, Derrick Bennett, Kavi Bhalla, Boris Bikbov, Aref Bin Abdulhak, Gretchen Birbeck, Fiona Blyth, Ian Bolliger, Soufiane Boufous, Chiara Bucello, Michael Burch, Peter Burney, Jonathan Carapetis, Honglei Chen, David Chou, Sumeet S Chugh, Luc E Coffeng, Steven D Colan, Samantha Colquhoun, K Ellicott Colson, John Condon, Myles D Connor, Leslie T Cooper, Matthew Corriere, Monica Cortinovis, Karen Courville de Vaccaro, William Couser, Benjamin C Cowie, Michael H Criqui, Marita Cross, Kaustubh C Dabhadkar, Nabila Dahodwala, Diego De Leo, Louisa Degenhardt, Allyne Delossantos, Julie Denenberg, Don C Des Jarlais, Samath D Dharmaratne, E Ray Dorsey, Tim Driscoll, Herbert Duber, Beth Ebel, Patricia J Erwin, Patricia Espindola, Majid Ezzati, Valery Feigin, Abraham D Flaxman, Mohammad H Forouzanfar, Francis Gerry R Fowkes, Richard Franklin, Marlene Fransen, Michael K Freeman, Sherine E Gabriel, Emmanuela Gakidou, Flavio Gaspari, Richard F Gillum, Diego Gonzalez-Medina, Yara A Halasa, Diana Haring, James E Harrison, Rasmus Havmoeller, Roderick J Hay, Bruno Hoen, Peter J Hotez, Damian Hoy, Kathryn H Jacobsen, Spencer L James, Rashmi Jasrasaria, Sudha Jayaraman, Nicole Johns, Ganesan Karthikeyan, Nicholas Kassebaum, Andre Keren, Jon-Paul Khoo, Lisa Marie Knowlton, Olive Kobusingye, Adofo Koranteng, Rita Krishnamurthi, Michael Lipnick, Steven E Lipshultz, Summer Lockett Ohno, Jacqueline Mabweijano, Michael F MacIntyre, Leslie Mallinger, Lyn March, Guy B Marks, Robin Marks, Akira Matsumori, Richard Matzopoulos, Bongani M Mayosi, John H McAnulty, Mary M McDermott, John McGrath, George A Mensah, Tony R Merriman, Catherine Michaud, Matthew Miller, Ted R Miller, Charles Mock, Ana Olga Mocumbi, Ali A Mokdad, Andrew Moran, Kim Mulholland, M Nathan Nair, Luigi Naldi, K M Venkat Narayan, Kiumarss Nasseri, Paul Norman, Martin O'Donnell, Saad B Omer, Katrina Ortblad, Richard Osborne, Doruk Ozgediz, Bishnu Pahari, Jeyaraj Durai Pandian, Andrea Panozo Rivero, Rogelio Perez Padilla, Fernando Perez-Ruiz, Norberto Perico, David Phillips, Kelsey Pierce, C Arden Pope, Esteban Porrini, Farshad Pourmalek, Murugesan Raju, Dharani Ranganathan, Jürgen T Rehm, David B Rein, Guiseppe Remuzzi, Frederick P Rivara, Thomas Roberts, Felipe Rodriguez De León, Lisa C Rosenfeld, Lesley Rushton, Ralph L Sacco, Joshua A Salomon, Uchechukwu Sampson, Ella Sanman, David C Schwebel, Maria Segui-Gomez, Donald S Shepard, David Singh, Jessica Singleton, Karen Sliwa, Emma Smith, Andrew Steer, Jennifer A Taylor, Bernadette Thomas, Imad M Tleyjeh, Jeffrey A Towbin, Thomas Truelsen, Eduardo A Undurraga, N Venketasubramanian, Lakshmi Vijayakumar, Theo Vos, Gregory R Wagner, Mengru Wang, Wenzhi Wang, Kerrianne Watt, Martin A Weinstock, Robert Weintraub, James D Wilkinson, Anthony D Woolf, Sarah Wulf, Pon-Hsiu Yeh, Paul Yip, Azadeh Zabetian, Zhi-Jie Zheng, Alan D Lopez, Christopher J L Murray, Mohammad A AlMazroa, Ziad A Memish
BACKGROUND: Reliable and timely information on the leading causes of death in populations, and how these are changing, is a crucial input into health policy debates. In the Global Burden of Diseases, Injuries, and Risk Factors Study 2010 (GBD 2010), we aimed to estimate annual deaths for the world and 21 regions between 1980 and 2010 for 235 causes, with uncertainty intervals (UIs), separately by age and sex. METHODS: We attempted to identify all available data on causes of death for 187 countries from 1980 to 2010 from vital registration, verbal autopsy, mortality surveillance, censuses, surveys, hospitals, police records, and mortuaries...
December 15, 2012: Lancet
Brendan C Stack, Evan R Moore, Ryan H Belcher, Horace J Spencer, Donald L Bodenner
OBJECTIVE: To better understand relationships of parathyroid hormone (PTH) production, adenoma gamma counts, and adenoma mass in patients undergoing minimally radioguided invasive parathyroidectomy for primary hyperparathyroidism from single-gland disease. STUDY DESIGN: A prospective review of 104 patients operated on by a single surgeon. SETTING: University tertiary hospital. SUBJECTS: Adults who have primary hyperparathyroidism due to a single gland...
December 2012: Otolaryngology—Head and Neck Surgery
Robert Farra, Norman F Sheppard, Laura McCabe, Robert M Neer, James M Anderson, John T Santini, Michael J Cima, Robert Langer
The first clinical trial of an implantable microchip-based drug delivery device is discussed. Human parathyroid hormone fragment (1-34) [hPTH(1-34)] was delivered from the device in vivo. hPTH(1-34) is the only approved anabolic osteoporosis treatment, but requires daily injections, making patient compliance an obstacle to effective treatment. Furthermore, a net increase in bone mineral density requires intermittent or pulsatile hPTH(1-34) delivery, a challenge for implantable drug delivery products. The microchip-based devices, containing discrete doses of lyophilized hPTH(1-34), were implanted in eight osteoporotic postmenopausal women for 4 months and wirelessly programmed to release doses from the device once daily for up to 20 days...
February 22, 2012: Science Translational Medicine
James Norman, Jose Lopez, Douglas Politz
BACKGROUND: Our group championed the techniques and benefits of unilateral parathyroidectomy. As our experience has matured, it seems this limited operation might be appropriate only occasionally. METHODS: A single surgical group's experience with 15,000 parathyroidectomies examined the ongoing differences between unilateral and bilateral techniques for 10-year failure/recurrence, multigland removal, operative times, and length of stay. RESULTS: With limited experience, 100% of operations were bilateral, decreasing to 32% by the 500(th) operation (p < 0...
March 2012: Journal of the American College of Surgeons
James Norman
No abstract text is available yet for this article.
January 2012: Journal of Surgical Oncology
Danielle Press, Douglas Politz, Jose Lopez, James Norman
BACKGROUND: Low vitamin D-25 is common in primary hyperparathyroidism but the effect of this deficiency on postparathyroidectomy calcium requirements is unclear. METHODS: A prospective study was conducted on 4 groups based on preoperative vitamin D-25 levels: very low (<20 ng/mL, n = 500); low (21 to 30 ng/mL, n = 500); normal (>30 ng/mL, n = 500); and supplemented (<25 ng/mL supplemented to >40 ng/mL, n = 285). Patients were placed on identical postoperative oral calcium regimens, and hypocalcemia symptoms were recorded...
December 2011: Surgery
Ann Young, Anthony B Hodsman, Neil Boudville, Colin Geddes, John Gill, David Goltzman, Sarbjit Vanita Jassal, Scott Klarenbach, Gregory Knoll, Norman Muirhead, G V Ramesh Prasad, Darin Treleaven, Amit X Garg
BACKGROUND: Living kidney donation offers a unique setting to study changes in phosphate and vitamin D homeostasis attributable to mild isolated decreases in estimated glomerular filtration rate (eGFR). STUDY DESIGN: Cross-sectional study. SETTING & PARTICIPANTS: 198 living kidney donors and 98 nondonor controls from 9 transplant centers across 3 countries. For donors, median time after donation was 5.3 years. At assessment, donors had a lower eGFR than controls (73 vs 98 mL/min/1...
June 2012: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
James Norman, Jose Lopez, Doug Politz
BACKGROUND: Cinacalcet (Sensipar) has been shown to decrease calcium levels in patients with primary hyperparathyroidism (PHPT); however, few other endpoints have been studied and long-term effects are not known. METHODS: At the discretion of a referring doctor, 70 patients began Cinacalcet as an alternative to surgery for PHPT. Patients were followed as long as the drug was tolerated at which time all underwent parathyroidectomy. RESULTS: Before treatment, serum calcium levels averaged 11...
May 2012: Annals of Surgical Oncology
Amy R Quillo, Jeffery M Bumpous, Richard E Goldstein, Muffin M Fleming, Michael B Flynn
The 20 per cent rule proposed by Norman established a guideline using radioactivity in the minimally invasive radioguided parathyroidectomy (MIRP) technique to localize and confirm removal of an abnormal parathyroid gland in patients with primary hyperparathyroidism. If radioactivity in the resected gland was at least 20 per cent of excision site/background radioactivity, the 20 per cent rule was satisfied. Patients meeting these criteria underwent unilateral MIRP without intraoperative parathyroid hormone assay or intraoperative frozen section...
April 2011: American Surgeon
Arnold Goodman, Doug Politz, Jose Lopez, James Norman
OBJECTIVE: It has been taught that a missing parathyroid adenoma can be within the thyroid. Therefore, thyroid lobectomy is appropriate when an adenoma cannot be found. Unfortunately, this technique is often futile. The purpose of this study is to examine the frequency of unsuccessful thyroid lobectomy in parathyroid surgery and to look at the true incidence and location of intrathyroid parathyroid adenomas (iT-PAs). STUDY DESIGN: A retrospective chart review of 11,163 patients undergoing parathyroid surgery identifying the location of more than 40,000 parathyroid glands...
June 2011: Otolaryngology—Head and Neck Surgery
James Norman, Arnold Goodman, Douglas Politz
OBJECTIVE: To better define the typical and atypical biochemical profiles of patients with surgically proven primary hyperparathyroidism. METHODS: In this single-center, prospectively conducted study of consecutive patients with surgically proven primary hyperparathyroidism over a 7-year period, we analyzed serum calcium, parathyroid hormone, and 25-hydroxyvitamin D concentrations. RESULTS: A total of 10 000 patients were included, and more than 210 000 calcium, parathyroid hormone, and 25-hydroxyvitamin D values were evaluated...
May 2011: Endocrine Practice
James Norman, Douglas Politz
BACKGROUND: Although localizing studies are well-known predictors of which patients are candidates for unilateral versus bilateral parathyroid exploration, there are a number of other factors that have positive or negative influence preoperatively and intraoperatively. STUDY DESIGN: A prospective study was conducted during 20 months on 3,000 consecutive patients undergoing surgery for primary hyperparathyroidism to determine which factors caused the surgeons to explore bilaterally or, in contrast, influenced a unilateral approach...
August 2010: Journal of the American College of Surgeons
Marie Vasher, Arnold Goodman, Douglas Politz, James Norman
BACKGROUND: To determine the amount and duration of supplemental oral calcium for patients with varying clinical presentations discharged immediately after surgery for primary hyperparathyroidism. STUDY DESIGN: A 4-year, prospective, single-institution study of 6,000 patients undergoing parathyroidectomy for primary hyperparathyroidism and discharged within 2.5 hours. Based on our previous studies, patients are started on a sliding scale of oral calcium determined by a number of preoperative measures (ie, serum calcium, body weight, osteoporosis) beginning 3 hours postoperation and decreasing to a maintenance dose by week 3...
July 2010: Journal of the American College of Surgeons
James Norman, Douglas Politz
BACKGROUND: Determining the physiologic activity (hormone production) of individual parathyroid glands can provide tremendous guidance during parathyroidectomy. METHODS: A 6.5-year prospective study of 5,000 patients with sporadic, non-multiple endocrime neoplasia (MEN) primary hyperparathyroidism who underwent surgery without frozen section or parathyroid hormone (PTH) assays was conducted. Patients who had a frozen section were not included; the removal of parathyroid glands was determined solely by the physiologic activity of each gland as determined by contained radioactivity...
March 2009: Annals of Surgical Oncology
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