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Plasmacytoma

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https://www.readbyqxmd.com/read/28325354/solitary-plasmacytoma-associated-with-epstein-barr-virus-a-clinicopathologic-cytogenetic-study-and-literature-review
#1
Jiaqi Yan, Jianchao Wang, Wenyan Zhang, Min Chen, Jie Chen, Weiping Liu
Solitary plasmacytoma (SP) is an uncommon, indolent tumor of plasma cell neoplasms that presents as a mass lesion in extramedullary sites. Evidence of Epstein-Barr virus (EBV) infection is frequently associated with various lymphatic and hematopoietic malignancies but is relatively rare in SP. Moreover, it is essential to distinguish EBV-positive plasmacytoma from plasmablastic lymphoma. In this study, we found 4 EBV-encoded RNA (EBER)-positive patients among 46 consecutive immunocompetent patients of SP and compared the clinicopathologic features of these patients with those of the EBER-negative cohort...
April 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28322099/clinical-analysis-of-40-multiple-myeloma-patients-with-extramedullary-plasmacytoma-of-the-head
#2
Wan-Jun Sun, Jia-Jia Zhang, Na An, Men Shen, Zhong-Xia Huang, Xin Li
Objectives To investigate the clinical characteristics, survival and prognosis of patients with multiple myeloma (MM) and head extramedullary plasmacytoma (EMP). Methods Forty MM patients were enrolled in the study (18 men, 22 women; median age, 55 years). Results Median overall survival (OS) and progression-free survival (PFS) were 24 (5-78) months and 17 (2-36) months, respectively. The 2-, 3- and 5-year OS rates were 51%, 20% and 7%, respectively. The 2-year PFS was 15%. Median OS and PFS in patients administered velcade were 26 (18-50) and 22...
December 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/28303141/the-function-of-fk506-binding-protein-13-in-protein-quality-control-protects-plasma-cells-from-endoplasmic-reticulum-stress-associated-apoptosis
#3
Mini Jeong, Eunkyeong Jang, Suk San Choi, Changhoon Ji, Kyungho Lee, Jeehee Youn
Plasma cells (PCs) are exposed to intense endoplasmic reticulum (ER) stress imposed by enormous rates of immunoglobulin (Ig) synthesis and secretion. Therefore, protein homeostasis is crucial for the survival of PCs, but its molecular mechanism remains largely unknown. Here, we found marked overexpression of FK506-binding protein 13 (FKBP13) in long-lived PCs from autoimmune mice and investigated its function using a plasmacytoma cell line secreting IgA. FKBP13 expression was induced largely in the lumen of ER in response to treatment with an ER stressor tunicamycin or overexpression of an adaptive unfolded protein response (UPR) protein X-box binding protein 1 (XBP1)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28302379/bilateral-sinonasal-extramedulary-plasmacytoma-treated-with-radiotherapy-and-a-medial-maxillectomy-with-a-denker-s-procedure
#4
Samuel N Helman, Peter Filip, Codrin Iacob, Patrick Colley
No abstract text is available yet for this article.
February 15, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28298739/plasmacytoma-of-the-trachea-a-surprising-diagnosis
#5
Márcio Luís Duarte, Mariana Carneiro Barbosa de Brito, Fabricius André Lyrio Traple, José Luiz Masson de Almeida Prado, Luiz Carlos Donoso Scoppetta
No abstract text is available yet for this article.
January 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/28296609/plasmacytomas-and-plasma-cell-leukemia
#6
Uqba Khan, Tarik Hadid
A 63-year-old man with IgG lambda multiple myeloma presented with progressive weakness and fatigue. He had received the diagnosis of IgG lambda multiple myeloma 4 years earlier and had been treated with several regimens. Physical examination revealed multiple exophytic subcutaneous lesions..
March 16, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28296507/lncrna-pvt1-epigenetically-silences-mir-195-and-modulates-emt-and-chemoresistance-in-cervical-cancer-cells
#7
Ching-Ju Shen, Ya-Min Cheng, Chiu-Lin Wang
The plasmacytoma variant translocation 1 gene (PVT1) is an oncogenic lncRNA with regulative effect on chemosensitivity in cervical cancer. However, the underlying mechanisms were not fully understood. In this study, HPV16 positive CaSki and SiHa cells were used as in-vitro cell model. Knockdown of HPV16 E7 significantly inhibited PVT1 and restored miR-195 expression. PVT1 directly interacts with EZH2 and the complex anchors in the promoter region of miR-195. PVT1 overexpression resulted in increased H3K27me3 levels in the miR-195 promoter region, while PVT1 knockdown decreased H3K27me3 levels in the promoter region...
March 15, 2017: Journal of Drug Targeting
https://www.readbyqxmd.com/read/28282510/cxcr4-cd184-expression-on-stem-cell-harvest-and-cd34-cells-post-transplant
#8
Inas Asfour, Hanaa Afify, Shaza Elkourashy, Maryse Ayoub, Gihan Kamal, Mary Gamal, Ghada Elgohary
OBJECTIVES/BACKGROUND: CXCR4 is a receptor for stromal-derived factor-1 (SDF-1), a molecule that has a chemotactic activity for lymphocytes and is important in homing of hematopoietic stem cells to their adult marrow. We evaluated the CXCR4 (CD184) expression in the harvest cells and in the post-transplant bone marrow (BM) and its relation to engraftment, as determined by the consensus criteria and chimerism. METHODS: This is a prospective study which included 30 patients undergoing hematopoietic stem cell transplantation; 15 patients received autograft and 15 patients received allograft on dates between January 2012 and May 2014...
March 2, 2017: Hematology/oncology and Stem Cell Therapy
https://www.readbyqxmd.com/read/28280077/survival-of-patients-with-lymphoplasmacytic-lymphoma-and-solitary-plasmacytoma-in-germany-and-the-united-states-in-the-early-21st-century
#9
Janick Weberpals, Dianne Pulte, Lina Jansen, Sabine Luttmann, Bernd Holleczek, Alice Nennecke, Meike Ressing, Alexander Katalinic, Maximilian Merz, Hermann Brenner
No abstract text is available yet for this article.
March 9, 2017: Haematologica
https://www.readbyqxmd.com/read/28276314/long-non-coding-rna-pvt1-facilitates-cervical-cancer-progression-via-negative-regulating-of-mir-424
#10
Ya-Li Gao, Zi-Shen Zhao, Ming-Yun Zhang, Li-Jie Han, Yu-Jin Dong, Bo Xu
Emerging evidence suggests that the long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 gene (PVT1) is involved in pathogenesis of cervical cancer. However, the potential mechanism is rarely reported. Our study found that PVT1 was up-regulated in cervical cancer tissue and cell lines. After transfecting PVT1 siRNA, the proliferation, migration and invasion of cervical cancer cells were markedly decreased. MiRNA expression profiles demonstrate that miR-424 was markedly down-regulated in cervical cancer tissue...
March 8, 2017: Oncology Research
https://www.readbyqxmd.com/read/28267386/extramedullary-plasmacytoma-of-the-lateral-rectus-muscle
#11
Phillip A Tenzel, Kapil Mishra, Aleza Andron, Robert C Della Rocca, Harsha S Reddy
Plasmacytoma is an uncommon presentation of plasma cell malignancy, especially in the absence of multiple myeloma. Orbital plasmacytomas generally originate from bone, although few cases in the literature report orbital extramedullary plasmacytomas. We present the case of a 68-year-old man found to have a solitary extramedullary plasmacytoma in the lateral rectus muscle without further evidence of multiple myeloma. This case demonstrates a rare presentation for such a malignancy, and a review of the literature highlights the importance of proper workup and close monitoring to rule out multiple myeloma to guide management...
March 7, 2017: Orbit
https://www.readbyqxmd.com/read/28265576/long-noncoding-rna-pvt1-as-a-novel-diagnostic-biomarker-and-therapeutic-target-for-melanoma
#12
Xiangjun Chen, Guozhen Gao, Sha Liu, Li Yu, Dexiong Yan, Xingwei Yao, Weijing Sun, Dezhi Han, Hao Dong
Accumulating evidences indicated that plasmacytoma variant translocation 1 (PVT1) plays vital roles in several cancers. However, the expression, functions, and clinical values of PVT1 in melanoma are still unknown. In this study we measured the expression of PVT1 in clinical tissues and serum samples and explored the diagnostic value of PVT1 for melanoma and the effects of PVT1 on melanoma cell proliferation, cell cycle, and migration. Our results, combined with publicly available PVT1 expression data, revealed that PVT1 is upregulated in melanoma tissues compared with nonneoplastic nevi tissues...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28255490/plasmacytoid-urothelial-carcinoma-of-the-urinary-bladder-metastatic-to-the-duodenum-a-case-report-diagnostic-relevance-of-gata3-immunohistochemistry
#13
Hermann Brustmann
Plasmacytoid urothelial carcinoma (PUC) of the urinary bladder is a rare and aggressive subtype of urothelial carcinoma. Its deceptive morphology is characterized by a discohesive growth of cells with plasmacytoid morphology. Since this tumor might be confused with plasmacytoma, lymphoma, or carcinoma variants, appropriate diagnosis in small biopsy samples could be challenging. This study reports the case of a 53-year-old man who presented with frequent nocturnal urgency, without hematuria. A transurethral bladder and a prostate resection specimen displayed infiltration of neoplastic cells in a spray-like discohesive pattern with occasional formation of small irregular nests and cord-like arrangements...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28251542/sellar-and-clival-plasmacytomas-case-series-of-5-patients-with-systematic-review-of-65-published-cases
#14
REVIEW
Jane Lee, Edwin Kulubya, Barry D Pressman, Adam Mamelak, Serguei Bannykh, Gabriel Zada, Odelia Cooper
PURPOSE: Parasellar plasmacytomas are rare tumors localized to the sellar region arising from plasma cells. Knowledge of clinical, imaging, surgical, and pathological characteristics is limited to single case reports. METHODS: A retrospective analysis of five primary cases was conducted, followed by systematic review of English language articles using PubMed in accordance with PRISMA guidelines. RESULTS: Five primary case patients include four men and one woman, ages 60-77, followed up to 3 years...
March 1, 2017: Pituitary
https://www.readbyqxmd.com/read/28246589/difficult-endoscopic-diagnosis-of-a-pancreatic-plasmacytoma-case-report-and-review-of-literature
#15
Nicolas Williet, Radwan Kassir, Muriel Cuilleron, Olivier Dumas, Leslie Rinaldi, Karine Augeul-Meunier, Michèle Cottier, Xavier Roblin, Jean-Marc Phelip
A 71-year-old man, with history of plasmacytoma in relapse since one year, was hospitalized for a initial presentation of acute pancreatitis and hepatitis. Although there was a heterogeneous infiltration around the pancreas head, the diagnosis of an extramedullary localization of his plasmacytoma was not made until later. This delayed diagnosis was due to the lack of specific radiologic features and the lack of dilatation of biliary ducts at the admission. A diagnosis was made with a simple ultrasound guided paracentesis of the low abundance ascites after a transjugular hepatic biopsy, an endoscopic ultrasound-guided fine needle aspiration of the pancreatic mass, and a failed attempt of biliary drainage through endoscopic retrograde cholangiopancreatography...
February 10, 2017: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28240504/solitary-extramedullary-plasmacytoma-of-the-colon-rectum-and-anus
#16
M Mjoli, N Vorajee, Y Naidoo, T Madiba
Solitary extramedullary plasmacytoma (SEP) is a neoplastic proliferation of a single clone of plasma cells that occur outside of the bone and bone marrow. It is rare, commonly occurring in the head and neck region, followed by the gastrointestinal tract. The aetiology, risk factors, natural history and consequent treatment are not well defined. We report an unusual case of SEP of the colon in an human immunodeficiency virus (HIV)-infected patient. The patient was managed with colonic resection and made an uneventful recovery...
June 2016: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28203342/optimizing-current-and-emerging-therapies-in-multiple-myeloma-a-guide-for-the-hematologist
#17
REVIEW
Shahzad Raza, Rachael A Safyan, Evan Rosenbaum, Alex S Bowman, Suzanne Lentzsch
Multiple myeloma (MM) is the second most common hematologic malignancy. The diagnosis of MM requires ⩾10% clonal plasma cells in the bone marrow or biopsy-proven plasmacytoma, plus evidence of end-organ damage (hypercalcemia, renal failure, anemia, and lytic bone lesions). The definition of MM has recently been expanded to include a ⩾60% clonal plasma cell burden in the bone marrow, serum involved/uninvolved light chain ratio of ⩾100, or more than one focal lesion on magnetic resonance imaging ⩾5 mm in the absence of end-organ damage...
February 2017: Therapeutic Advances in Hematology
https://www.readbyqxmd.com/read/28195903/muscle-involvement-of-multiple-myeloma-revealed-by-fdg-pet-ct
#18
Meng Liang, Minggang Su, Rang Wang, Weiya Wang, Chengzhong Fan
Extramedullary myeloma can occur in variety of organs; however, muscle involvement is rarely reported. Here we present a case of a multiple myeloma patient with muscle involvement found by F-FDG PET/CT, which is sensitive in detecting extramedullary lesions of multiple myeloma. Plasmacytoma was confirmed by pathological biopsy afterwards.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited...
February 13, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28194070/intriguing-morphology-of-igg-lambda-secreting-myeloma-cells
#19
Sreejesh Sreedharanunni, Narender Kumar, Neelam Varma
Myeloma cells are known to show varied morphology and various types of nuclear or cytoplasmic inclusions. There are a few reports of myeloma with presence of pseudo-Gaucher type histiocytes; however myeloma cells itself resembling storage histiocytes is distinctly uncommon. We report images of plasma cells resembling storage cells from a case of IgG/lambda plasma cell myeloma. Hematopathologist must be aware of such varied morphology of plasma cells especially while dealing with extra medullary plasmacytomas...
March 2017: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/28192381/plasmacytoma-of-the-temporal-bone-a-great-imitator-report-of-seven-cases-and-comprehensive-review-of-the-literature
#20
Alex D Sweeney, Jacob B Hunter, S Vincent Rajkumar, John I Lane, Dragan Jevremovic, Matthew L Carlson
OBJECTIVES: To describe the clinical presentation, radiological features, and outcome of patients with plasmacytoma of the temporal bone. METHODS: Multicenter retrospective case series of all patients diagnosed with plasmacytoma of the temporal bone between 1990 and 2015. Comprehensive literature review of all previously published cases. RESULTS: A total of seven patients (average age, 57.3 yr; 57% women) met inclusion criteria. Three (43%) had a known history of multiple myeloma (MM)...
March 2017: Otology & Neurotology
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