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Plasmacytoma

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https://www.readbyqxmd.com/read/28431708/extramedullary-plasmacytoma-arising-from-the-anterior-mediastinum
#1
Kiyoshi Sato, Satoshi Fumimoto, Takehisa Fukada, Yoshio Ichihashi, Kaoru Ochi, Hidetoshi Satomi, Takuya Morita, Nobuharu Hanaoka, Yoshikatsu Okada, Takahiro Katsumata
Plasmacytomas are a localized proliferation of plasma cells in the bone marrow and soft tissue. Extramedullary plasmacytomas are rare and typically solitary plasma cell neoplasms originating from extraosseous organs and tissues. A 31-year-old woman was referred to our hospital with a rapidly growing abnormal shadow on a chest roentgenogram. Chest computed tomography showed that the lesion was located in the anterior mediastinum. She underwent surgery, and the tumor was diagnosed as an extramedullary plasmacytoma...
May 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28424097/unusual-course-of-generalized-lymph-node-primary-plasmacytoma-in-a-patient-with-sj%C3%A3-gren-s-syndrome-a-case-report
#2
Vadim R Gorodetskiy, Natalya A Probatova, Vladimir I Vasilyev
BACKGROUND: Primary lymph node plasmacytoma is a rare disease that typically involves lymph nodes of the neck. In only 15% of cases is the disease generalized. Here, we present a case of generalized lymph node plasmacytoma in a patient with Sjögren's syndrome with an unusual course. CASE PRESENTATION: A 48-year-old white woman presented to our hospital with enlargement of groups of lymph nodes, liver, and spleen. Her medical history was consistent with a 12-year course of Sjögren's syndrome...
April 20, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28420651/anorectal-involvement-in-a-patient-with-multiple-myeloma
#3
Pedro Russo, Ana Luisa Tomé, Tiago Capela, Maria João Bettencourt
Multiple myeloma is a neoplastic proliferation of monoclonal plasma cells. Symptomatic gastrointestinal involvement is uncommon. We report the case of a 45-year-old patient admitted with an anorectal polypoid lesion, which progressed to colonic obstruction. Investigation revealed a secondary plasmacytoma associated with multiple myeloma. We discuss the characteristics of this rare entity with poor prognosis, its clinical implications and treatment options.
April 18, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28413546/solitary-plasmacytoma-of-temporal-bone-a-rare-case-report
#4
Ritesh Kumar, Narendra Kumar, Sandeep Mohindro, B D Radotra
Solitary plasmacytoma of base of skull is a rare disease. It presents with headache, swelling, and other vague symptoms. Systemic work-up to rule out multiple myeloma is necessary. Radiotherapy is the treatment of choice. We, here, present a case of solitary plasmacytoma of base of skull in right temporal bone in a 50-year-old female treated with surgery and radiotherapy.
January 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28409043/rare-presentation-of-primary-extramedullary-plasmacytoma-as-lip-lesion
#5
Mali Him, Maggie Meier, Vikas Mehta
Malignant plasma cell proliferation can be presented as part of disseminated disease of multiple myeloma, as solitary plasmacytoma of bone, or in soft tissue as extramedullary plasmacytoma. Extramedullary plasmacytomas represented approximately 3% of all plasma cell proliferation. Approximately 80% of extramedullary plasmacytomas occur in the head and neck region while the other 4% occur in the skin and to a lesser extent in the lip. In this paper, we report a rare case of primary cutaneous plasmacytoma involving the lip in a 65-year-old male...
2017: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/28405083/plasmablastic-plasmacytoma-of-the-breast
#6
Don K Le, David Metter, John R Krause
Breast plasmacytomas are extremely rare entities that can be seen as primary malignant neoplasms in the absence of bone involvement or as secondary neoplasms from disseminated multiple myeloma. Clinicians should be aware of this entity, as it may mimic benign and malignant lesions in the breast. Microscopically, immature plasmacytomas may mimic other neoplasms, so caution should be made on histological examination to ensure the correct diagnosis and corresponding therapy. Here we present a case of a plasmablastic plasmacytoma of the breast in a 55-year-old woman that was originally thought to be an angiosarcoma...
April 2017: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/28402206/second-cancers-in-survivors-of-plasmacytoma-of-bone-in-the-u-s-a-a-seer-database-analysis
#7
Mohamed Abd El-Fattah
No abstract text is available yet for this article.
April 12, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28401875/-tumors-of-unknown-origin-case-report
#8
Arni Jon Geirsson, Sigridur Thordis Valtysdottir, Andres Sigvaldason, Margret Sigurdardottir
IgG4 related disease is a recently recognized chronic fibrotic, inflammatory condition, caused by infiltrating IgG4 positive plasma cells that can cause tumor like disease in almost any organ in the body. Typical histopathology is lymphoplasmocytic infiltration of IgG4 positive cells, storiform fibrosis and obliterative phlebitis. Glucocorticoids alone or in combination with B-cell depletion with rituximab causes often good, lasting response. We present here a lady with recurrent lung infiltration that simulated pneumonia and later tumor of the lung...
April 2017: Læknablađiđ
https://www.readbyqxmd.com/read/28395104/hhv8-kshv-positive-lymphoproliferative-disorders-and-the-spectrum-of-plasmablastic-and-plasma-cell-neoplasms-2015-sh-eahp-workshop-report-part-3
#9
Amy Chadburn, Jonathan Said, Dita Gratzinger, John K C Chan, Daphne de Jong, Elaine S Jaffe, Yasodha Natkunam, John R Goodlad
Objectives: The 2015 Workshop of the Society for Hematopathology/European Association for Haematopathology aimed to review immunodeficiency-related lymphoproliferative disorders with plasmablastic and plasma cell differentiation. Methods: The workshop panel reviewed human herpes virus 8 (HHV8)/Kaposi sarcoma herpesvirus (KSHV)-associated lesions and other lesions exhibiting plasma cell differentiation, including plasmablastic proliferations with features of myeloma/plasmacytoma, plasmablastic neoplasms presenting in extranodal sites and effusion-based lymphomas, and rendered a consensus diagnosis...
February 1, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28393375/long-term-outcome-of-patients-with-solitary-plasmacytoma-treated-with-radiotherapy-a-population-based-single-center-study-with-median-follow-up-of-13-7%C3%A2-years
#10
Dlawer Abdulla Barzenje, Arne Kolstad, Waleed Ghanima, Harald Holte
In this single-center, population-based, and retrospective study, we analyzed the outcome of 49 patients with solitary bone plasmacytoma (SBP) and 28 patients with solitary extramedullary plasmacytoma (SEP), all treated with radiotherapy. Laminectomy was performed in 18/30 SBP patients with vertebral involvement and tumour resection in 10 SEP patients. Overall survival and cause of death for each patient were compared to 5 sex-, age-, and residency-matched individuals from the normal population. Response (complete and partial) was achieved in 94% of SBP and 96% of SEP patients...
April 9, 2017: Hematological Oncology
https://www.readbyqxmd.com/read/28391160/long-non-coding-rna-pvt1-promote-lps-induced-septic-acute-kidney-injury-by-regulating-tnf%C3%AE-and-jnk-nf-%C3%AE%C2%BAb-pathways-in-hk-2-cells
#11
Wei Huang, Xiuwen Lan, Xueting Li, Dawei Wang, Yinghao Sun, Qian Wang, Hong Gao, Kaijiang Yu
This study aimed to investigate the effect and underlying mechanism of long non-coding RNA plasmacytoma variant translocation 1 (PVT1) in lipopolysaccharide (LPS)-induced inflammation injury in HK-2 cells. We established LPS-induced septic acute kidney injury (AKI) model in HK-2 cells. LPS-induced HK-2 cells were transfected with pc-PVT1, pc-NC, si-PVT1 or si-NC. Cell viability and apoptosis rate were detected by MTT assay and Annexin V-FITC/PI Apoptosis Detection kit, respectively. The relationships of PVT1 and inflammatory factors were evaluated by RNA Immunoprecipitation (RIP) assay...
April 6, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28381186/the-expression-pattern-of-long-non-coding-rna-pvt1-in-tumor-tissues-and-in-extracellular-vesicles-of-colorectal-cancer-correlates-with-cancer-progression
#12
Kai Guo, Jie Yao, Qiang Yu, Zijian Li, Hu Huang, Jianguo Cheng, Zhigang Wang, Yunfeng Zhu
The plasmacytoma variant translocation 1 gene (PVT1) is a large non-coding locus at adjacent of c-Myc, and long non-coding RNA PVT1 is now recognized as a cancerous gene co-amplified with c-Myc in various cancers. But the expression and functional role of PVT1 in colorectal cancer are still unelucidated. In addition, all the reported long non-coding RNAs so far are discovered in either cells or tissues, but no research about long non-coding RNAs detection in extracellular vesicles has been reported yet. In the present study, we firstly investigated the expression of PVT1 in colorectal cancer specimens and its correlation with the expression of c-Myc and other related genes by real-time polymerase chain reaction...
April 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28368259/role-of-18-f-fdg-pet-ct-in-the-diagnosis-and-management-of-multiple-myeloma-and-other-plasma-cell-disorders-a-consensus-statement-by-the-international-myeloma-working-group
#13
REVIEW
Michele Cavo, Evangelos Terpos, Cristina Nanni, Philippe Moreau, Suzanne Lentzsch, Sonja Zweegman, Jens Hillengass, Monika Engelhardt, Saad Z Usmani, David H Vesole, Jesus San-Miguel, Shaji K Kumar, Paul G Richardson, Joseph R Mikhael, Fernando Leal da Costa, Meletios-Athanassios Dimopoulos, Chiara Zingaretti, Niels Abildgaard, Hartmut Goldschmidt, Robert Z Orlowski, Wee Joo Chng, Hermann Einsele, Sagar Lonial, Bart Barlogie, Kenneth C Anderson, S Vincent Rajkumar, Brian G M Durie, Elena Zamagni
The International Myeloma Working Group consensus aimed to provide recommendations for the optimal use of (18)fluorodeoxyglucose ((18)F-FDG) PET/CT in patients with multiple myeloma and other plasma cell disorders, including smouldering multiple myeloma and solitary plasmacytoma. (18)F-FDG PET/CT can be considered a valuable tool for the work-up of patients with both newly diagnosed and relapsed or refractory multiple myeloma because it assesses bone damage with relatively high sensitivity and specificity, and detects extramedullary sites of proliferating clonal plasma cells while providing important prognostic information...
April 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28355965/long-noncoding-rna-pvt1-promotes-emt-and-cell-proliferation-and-migration-through-downregulating-p21-in-pancreatic-cancer-cells
#14
Bao-Qiang Wu, Yong Jiang, Feng Zhu, Dong-Lin Sun, Xiao-Zhou He
BACKGROUND AND AIM: Long noncoding RNA-plasmacytoma variant translocation 1 is identified to be highly expressed and exhibits oncogenic activity in a variety of human malignancies, including pancreatic cancer. However, little is known about the overall biological role and mechanism of plasmacytoma variant translocation 1 in pancreatic cancer so far. In this study, we investigated the effect of plasmacytoma variant translocation 1 on pancreatic cancer cell proliferation and migration as well as epithelial-mesenchymal transition...
January 1, 2017: Technology in Cancer Research & Treatment
https://www.readbyqxmd.com/read/28351195/utility-of-flow-cytometry-in-diagnosing-hematologic-malignancy-in-tonsillar-tissue
#15
Omonigho Aisagbonhi, Michelle DeLelys, Nicole Hartford, Frederic Preffer, Amy Ly
OBJECTIVE: Tonsil surgical biopsy or excision is a very common procedure. However, there exist no consensus guidelines for the pathologic handling of tonsil specimens; gross and/or microscopic evaluation may be used. Diagnosis of tonsillar hematologic malignancy requires histology, immunohistochemistry and/or flow cytometry. Data regarding the utility of flow cytometry in tonsillar tissues are limited. We assessed our experience with flow cytometry for tonsil diagnosis with regard to accuracy and use patterns at a tertiary academic medical center...
March 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28325354/solitary-plasmacytoma-associated-with-epstein-barr-virus-a-clinicopathologic-cytogenetic-study-and-literature-review
#16
Jiaqi Yan, Jianchao Wang, Wenyan Zhang, Min Chen, Jie Chen, Weiping Liu
Solitary plasmacytoma (SP) is an uncommon, indolent tumor of plasma cell neoplasms that presents as a mass lesion in extramedullary sites. Evidence of Epstein-Barr virus (EBV) infection is frequently associated with various lymphatic and hematopoietic malignancies but is relatively rare in SP. Moreover, it is essential to distinguish EBV-positive plasmacytoma from plasmablastic lymphoma. In this study, we found 4 EBV-encoded RNA (EBER)-positive patients among 46 consecutive immunocompetent patients of SP and compared the clinicopathologic features of these patients with those of the EBER-negative cohort...
April 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28322099/clinical-analysis-of-40-multiple-myeloma-patients-with-extramedullary-plasmacytoma-of-the-head
#17
Wan-Jun Sun, Jia-Jia Zhang, Na An, Men Shen, Zhong-Xia Huang, Xin Li
Objectives To investigate the clinical characteristics, survival and prognosis of patients with multiple myeloma (MM) and head extramedullary plasmacytoma (EMP). Methods Forty MM patients were enrolled in the study (18 men, 22 women; median age, 55 years). Results Median overall survival (OS) and progression-free survival (PFS) were 24 (5-78) months and 17 (2-36) months, respectively. The 2-, 3- and 5-year OS rates were 51%, 20% and 7%, respectively. The 2-year PFS was 15%. Median OS and PFS in patients administered velcade were 26 (18-50) and 22...
December 2016: Journal of International Medical Research
https://www.readbyqxmd.com/read/28303141/the-function-of-fk506-binding-protein-13-in-protein-quality-control-protects-plasma-cells-from-endoplasmic-reticulum-stress-associated-apoptosis
#18
Mini Jeong, Eunkyeong Jang, Suk San Choi, Changhoon Ji, Kyungho Lee, Jeehee Youn
Plasma cells (PCs) are exposed to intense endoplasmic reticulum (ER) stress imposed by enormous rates of immunoglobulin (Ig) synthesis and secretion. Therefore, protein homeostasis is crucial for the survival of PCs, but its molecular mechanism remains largely unknown. Here, we found marked overexpression of FK506-binding protein 13 (FKBP13) in long-lived PCs from autoimmune mice and investigated its function using a plasmacytoma cell line secreting IgA. FKBP13 expression was induced largely in the lumen of ER in response to treatment with an ER stressor tunicamycin or overexpression of an adaptive unfolded protein response (UPR) protein X-box binding protein 1 (XBP1)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28302379/bilateral-sinonasal-extramedulary-plasmacytoma-treated-with-radiotherapy-and-a-medial-maxillectomy-with-a-denker-s-procedure
#19
Samuel N Helman, Peter Filip, Codrin Iacob, Patrick Colley
No abstract text is available yet for this article.
February 15, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28298739/plasmacytoma-of-the-trachea-a-surprising-diagnosis
#20
Márcio Luís Duarte, Mariana Carneiro Barbosa de Brito, Fabricius André Lyrio Traple, José Luiz Masson de Almeida Prado, Luiz Carlos Donoso Scoppetta
No abstract text is available yet for this article.
January 2017: Radiologia Brasileira
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