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https://www.readbyqxmd.com/read/28681992/outcomes-and-patterns-of-failure-of-sarcomatoid-carcinoma-of-the-larynx-the-mayo-clinic-experience
#1
Mauricio E Gamez, Elizabeth Jeans, Michael L Hinni, Eric Moore, Geoffrey Young, Daniel Ma, Lisa McGee, Matthew R Buras, Samir H Patel
OBJECTIVES/HYPOTHESIS: Sarcomatoid carcinoma is a rare variant of squamous cell carcinoma of the head and neck. No consensus exists on its management. Our aim was to present our outcomes. STUDY DESIGN: Retrospective study. Median follow-up 45 months. METHODS: There were 38 patients with pathologically confirmed sarcomatoid carcinoma of the larynx treated at the Mayo Clinic from 1990 to 2014. Statistical analysis of overall survival (OS), progression-free survival (PFS), and local control (LC) were conducted using the Kaplan-Meier method...
July 6, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28670118/species-specific-identification-of-collagen-components-in-colla-corii-asini-using-a-nano-liquid-chromatography-tandem-mass-spectrometry-proteomics-approach
#2
Xue Li, Feng Shi, Liping Gong, Baojian Hang, Daoyuan Li, Lianli Chi
Colla corii asini (CCA) is a protein-based traditional Chinese medicine made from donkey skins. Because it has the ability to nourish blood, its demand is increasing rapidly. The shortage of donkey skins increases the risk of the adulteration of CCA products with other animal skins. To ensure the drug efficacy and safety of CCA products, a proteomics technique was applied to reveal proteins in the skins of donkey, horse, cattle, and pig. Species-specific peptides for each animal species were predicted using bioinformatics, and their presence in the skins and gelatin samples was examined by nano-liquid chromatography-tandem mass spectrometry (nano-LC-MS/MS)...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28513078/peripheral-synucleinopathy-in-early-parkinson-s-disease-submandibular-gland-needle-biopsy-findings
#3
Charles H Adler, Brittany N Dugger, Joseph G Hentz, Michael L Hinni, David G Lott, Erika Driver-Dunckley, Shyamal Mehta, Geidy Serrano, Lucia I Sue, Amy Duffy, Anthony Intorcia, Jessica Filon, Joel Pullen, Douglas G Walker, Thomas G Beach
No abstract text is available yet for this article.
May 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28490408/endoscopic-resection-of-sinonasal-mucosal-melanoma-has-comparable-outcomes-to-open-approaches
#4
Amar Miglani, Samir H Patel, Heidi E Kosiorek, Michael L Hinni, Richard E Hayden, Devyani Lal
BACKGROUND: Endoscopic endonasal resection (EER) of sinonasal mucosal melanoma (SMM) is a newer surgical alternative to traditional external and/or open resection (OR). Studies on long-term outcomes are necessary to validate EER for this aggressive sinonasal malignancy. OBJECTIVE: To compare outcomes of EER versus OR in SMM. METHODS: A case series of patients who underwent surgical resection of SMM at a tertiary-care institution (2000-2015) was studied retrospectively...
May 1, 2017: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28122110/invasive-fungal-laryngopharyngitis-resulting-in-laryngeal-destruction-with-complete-laryngotracheal-separation-report-of-a-case
#5
Tyler Swiss, Sergio Santino Cervantes, Michael Hinni, David G Lott
As the treatment of hematopoietic cancers evolves, otolaryngologists will see a higher incidence of opportunistic infections. We discuss a case of invasive fungal disease that invaded the larynx, pharynx, trachea, and pulmonary parenchyma after chemotherapy. The patient, a 46-year-old woman, presented 1 week after undergoing induction chemotherapy. Her initial symptoms were odynophagia and dysphagia. Despite encouraging findings on physical examination, her health rapidly declined and she required an urgent tracheotomy and multiple operations to address spreading necrosis...
January 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28056518/mucosal-sparing-radiation-therapy-in-resected-oropharyngeal-cancer
#6
Mauricio E Gamez, Michele Y Halyard, Michael L Hinni, Richard E Hayden, Thomas H Nagel, Carlos E Vargas, William W Wong, Kelly K Curtis, Matthew A Zarka, Daniel Ma, Samir H Patel
PURPOSE: To report the outcomes of patients with favorable risk oropharyngeal cancer that underwent adjuvant radiation therapy with omission of the primary site from the clinical target volume (CTV). MATERIAL/METHODS: A retrospective study of 40 patients treated with transoral surgery (TOS) followed by neck only radiation using intensity modulated radiation therapy (IMRT) with exclusion of the primary site. For all patients, a CTV of the primary surgical bed was contoured to obtain the estimated incidental dose to the primary site...
December 1, 2016: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/27871494/current-surgical-management-of-carotid-body-tumors
#7
MULTICENTER STUDY
Victor J Davila, James M Chang, William M Stone, Richard J Fowl, Thomas C Bower, Michael L Hinni, Samuel R Money
BACKGROUND: Carotid body tumors (CBTs) are rare. Management guidelines may include genetic testing for succinate dehydrogenase (SDH) mutations. We performed an institutional review of the surgical management of CBT. METHODS: A retrospective analysis (1994-2015) of CBT excisions at our institution was performed. Data obtained included demographics, genetic testing (if performed), intraoperative details, postoperative morbidity, and long-term outcomes. Data from the first CBT excision were included in patients with bilateral tumors...
December 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27706783/short-communication-quick-method-for-identifying-horse-equus-caballus-and-donkey-equus-asinus-hybrids
#8
M M Franco, J B F Santos, A S Mendonça, T C F Silva, R C Antunes, E O Melo
The domestication of the Equus genus 5000-6000 years ago has influenced the history of human civilization. As soon as horse and donkey species had been domesticated, they were crossbred, producing humanity's first documented attempt at animal genome manipulation. Since then, the mule (male donkey x female horse) and the reciprocal cross (the hinny, male horse x female donkey) have been the most common equine hybrids in the world. Due to their hybrid vigor, mules and hinnies have been intensively used for carrying loads and people and for tilling the land...
September 23, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27674495/the-effect-of-treatment-time-on-outcomes-in-favorable-risk-oropharyngeal-tumors-treated-with-transoral-surgery-followed-by-radiation-therapy
#9
M E Gamez, S E Schild, M Y Halyard, M L Hinni, H E Richard, T H Nagel, C Vargas, W W Wong, C Rayfield, S H Patel
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27561845/the-impact-of-family-history-on-non-medullary-thyroid-cancer
#10
REVIEW
I J Nixon, C Suárez, R Simo, A Sanabria, P Angelos, A Rinaldo, J P Rodrigo, L P Kowalski, D M Hartl, M L Hinni, J P Shah, A Ferlito
INTRODUCTION: Around 10% of patients with non-medullary thyroid cancer (NMTC) will have a positive family history for the disease. Although many will be sporadic, families where 3 first-degree relatives are affected can be considered to represent true familial non-medullary thyroid cancer (FNMTC). The genetic basis, impact on clinical and pathological features, and overall effect on prognosis are poorly understood. METHODS: A literature review identified articles which report on genetic, clinical, therapeutic and screening aspects of FNMTC...
October 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27026738/human-papillomavirus-vaccination-counseling-in-pediatric-training-are-we-discussing-otolaryngology-related-manifestations
#11
Sharon H Gnagi, Forrest T Gnagi, Scott A Schraff, Michael L Hinni
OBJECTIVE: Demonstrate the need for increased education regarding otolaryngology-related manifestations of human papillomavirus (HPV). Highlight a need to incorporate otolaryngology-related manifestations of HPV in vaccine counseling. STUDY DESIGN: Survey. SETTING: Tertiary care academic children's hospital. SUBJECTS: Pediatric residents, fellows, and staff. METHODS: An online survey was made available regarding HPV education and vaccination...
July 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/26954128/testicular-characteristics-and-the-block-to-spermatogenesis-in-mature-hinny
#12
Hongmei Han, Aihong Wang, Liming Liu, Gaoping Zhao, Jie Su, Biao Wang, Yunxia Li, Jindun Zhang, Baojiang Wu, Wei Sun, Shuxiang Hu, Shuyu Li, Lixia Zhao, Xihe Li
Most hinnies (female donkey×male horse) and mules (female horse×male donkey) are sterile with few reports of equine fertile hybrids. The main cause of this sterility is thought to be a meiotic block to spermatogenesis and oogenesis. This study compared the developmental features of the testes and a histological analyses of spermatogenesis in a male hinny with those of a normal, fertile stallion and Jack donkey. Hinny testes showed a thicker tunica albuginea, fewer blood vessels and more connective tissue in the testis parenchyma than those of the stallion and Jack donkey...
June 2016: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/26799362/peripheral-synucleinopathy-in-early-parkinson-s-disease-submandibular-gland-needle-biopsy-findings
#13
Charles H Adler, Brittany N Dugger, Joseph G Hentz, Michael L Hinni, David G Lott, Erika Driver-Dunckley, Shyamal Mehta, Geidy Serrano, Lucia I Sue, Amy Duffy, Anthony Intorcia, Jessica Filon, Joel Pullen, Douglas G Walker, Thomas G Beach
INTRODUCTION: Finding a peripheral tissue biopsy site to diagnose early PD would be of value for clinical care, biomarker validation, and as research enrollment criteria. Whereas autopsy and advanced PD studies suggest that the submandibular gland is an important biopsy site, there are no studies in early PD. The aim of this study was to determine whether needle biopsy of the submandibular gland reveals Lewy type alpha-synucleinopathy in early PD. METHODS: Twenty-five early PD (duration < 5 years) and 10 controls underwent transcutaneous needle core biopsies of the submandibular gland...
February 2016: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/26611246/high-grade-neuroendocrine-carcinoma-of-the-larynx-the-mayo-clinic-experience
#14
Nicholas L Deep, Dale C Ekbom, Michael L Hinni, Matthew A Zarka, Samir H Patel
OBJECTIVE: To report a single institutional series of high-grade neuroendocrine carcinoma of the larynx (NCL), a very rare yet aggressive tumor. To review the management of NCL, including discussion of clinical behavior, treatment outcome, and prognosis. METHOD: A retrospective chart review of high-grade laryngeal neuroendocrine carcinomas at a single institution, including small- and large-cell neuroendocrine carcinomas. A total of 8 patients with high-grade NCL treated at our institution from 1992 to 2014 were identified...
June 2016: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/26556462/short-term-quality-of-life-outcomes-following-transoral-diverticulotomy-for-zenker-s-diverticulum-a-prospective-single-group-study
#15
MULTICENTER STUDY
Kathryn M Van Abel, Nicole M Tombers, Kari A Krein, Eric J Moore, Daniel L Price, Jan L Kasperbauer, Michael L Hinni, David G Lott, Dale C Ekbom
OBJECTIVE: To prospectively analyze quality-of-life outcomes following transoral diverticulotomy with cricopharyngeal myotomy (DCPM) for Zenker's diverticulum (ZD). STUDY DESIGN: Prospective single-group study. SETTINGS: Tertiary academic institution. SUBJECTS AND METHODS: A prospective multicenter study performed from January 1, 2012, to July 1, 2014, included 18 patients presenting with ZD undergoing DCPM. Standardized questionnaires-including the 10-item Eating Assessment Tool (EAT-10), Functional Outcome of Swallowing Scale (FOSS), and the Reflux Symptom Index (RSI)-were completed preoperatively and at 3 and 6 months postoperatively...
February 2016: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/26488973/love-does-it
#16
Jane Bates
Hen, duck, dearie, hinny, love - these are just a selection of words we Brits use to express friendliness… words we get so used to hearing, we barely even register them.
October 21, 2015: Nursing Standard
https://www.readbyqxmd.com/read/26097325/bizarre-parosteal-osteochondromatous-proliferation-presenting-in-the-nasal-dorsum
#17
Matthew Mors, Santino S Cervantes, Michael Hinni
We present the first bizarre parosteal osteochondromatous proliferation (BPOP) in the nasal dorsum. These lesions have been described since 1983; however, the vast majority of these lesions do not present in the head and neck, although five cases exist in the literature. An understanding of the potential sites for bizarre paraosteal osteochondromatous proliferations will help lead to successful diagnosis and proper treatment.
January 2015: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/25761152/oropharyngeal-cancer-treatment-the-role-of-transoral-surgery
#18
REVIEW
Michael L Hinni, Thomas Nagel, Brittany Howard
PURPOSE OF REVIEW: This article reviews literature pertaining to squamous cell carcinoma (SCC) of the oropharynx and the evolution of transoral surgical (TOS) techniques for its management. Oncologists are recognizing a changing pattern in the cause of oropharyngeal cancer, namely the increasing incidence of HPV-associated tumors. An effort is underway to reduce the morbidity of treatment without jeopardizing survival. This is a timely discussion for reassessment of current standards of care and opening dialogue on treatment de-escalation...
April 2015: Current Opinion in Otolaryngology & Head and Neck Surgery
https://www.readbyqxmd.com/read/25663269/severe-prolonged-dysphagia-following-transoral-resection-of-bilateral-synchronous-tonsillar-carcinoma
#19
Alpen B Patel, Michael L Hinni, Taylor R Pollei, Richard E Hayden, Eric J Moore
OBJECTIVES: Alert the reader to the complication of severe dysphagia following transoral laser microsurgery (TLM) or transoral robotic surgery (TORS) for bilateral simultaneous or synchronous tonsillar squamous cell carcinoma. METHODS: A case series of four patients treated at an academic tertiary center between 2008 and 2012 is presented; two treated with transoral laser microsurgery and two with transoral robotic surgery for biopsy-proven untreated bilateral primary squamous cell carcinoma...
November 2015: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/25636250/a-novel-distending-laryngoscope-implications-in-transoral-surgery
#20
REVIEW
Michael L Hinni, Alpen B Patel, Thomas H Nagel, Brittany E Howard
The objective is to describe an innovative laryngoscope developed to improve visualization, provide greater exposure, and enhance precision and success during transoral procedures. A retrospective review of 170 patients who underwent transoral surgery with a new distending laryngoscope was conducted. We compared and contrasted our exposure within the oropharynx, hypopharynx, and larynx using the laryngoscope with that of currently available instrumentation. Specific mechanical dimensions of the laryngoscope along with the provided working field were calculated...
May 2016: European Archives of Oto-rhino-laryngology
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