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M M Franco, J B F Santos, A S Mendonça, T C F Silva, R C Antunes, E O Melo
The domestication of the Equus genus 5000-6000 years ago has influenced the history of human civilization. As soon as horse and donkey species had been domesticated, they were crossbred, producing humanity's first documented attempt at animal genome manipulation. Since then, the mule (male donkey x female horse) and the reciprocal cross (the hinny, male horse x female donkey) have been the most common equine hybrids in the world. Due to their hybrid vigor, mules and hinnies have been intensively used for carrying loads and people and for tilling the land...
September 23, 2016: Genetics and Molecular Research: GMR
M E Gamez, S E Schild, M Y Halyard, M L Hinni, H E Richard, T H Nagel, C Vargas, W W Wong, C Rayfield, S H Patel
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
I J Nixon, C Suárez, R Simo, A Sanabria, P Angelos, A Rinaldo, J P Rodrigo, L P Kowalski, D M Hartl, M L Hinni, J P Shah, A Ferlito
INTRODUCTION: Around 10% of patients with non-medullary thyroid cancer (NMTC) will have a positive family history for the disease. Although many will be sporadic, families where 3 first-degree relatives are affected can be considered to represent true familial non-medullary thyroid cancer (FNMTC). The genetic basis, impact on clinical and pathological features, and overall effect on prognosis are poorly understood. METHODS: A literature review identified articles which report on genetic, clinical, therapeutic and screening aspects of FNMTC...
October 2016: European Journal of Surgical Oncology
Sharon H Gnagi, Forrest T Gnagi, Scott A Schraff, Michael L Hinni
OBJECTIVE: Demonstrate the need for increased education regarding otolaryngology-related manifestations of human papillomavirus (HPV). Highlight a need to incorporate otolaryngology-related manifestations of HPV in vaccine counseling. STUDY DESIGN: Survey. SETTING: Tertiary care academic children's hospital. SUBJECTS: Pediatric residents, fellows, and staff. METHODS: An online survey was made available regarding HPV education and vaccination...
July 2016: Otolaryngology—Head and Neck Surgery
Hongmei Han, Aihong Wang, Liming Liu, Gaoping Zhao, Jie Su, Biao Wang, Yunxia Li, Jindun Zhang, Baojiang Wu, Wei Sun, Shuxiang Hu, Shuyu Li, Lixia Zhao, Xihe Li
Most hinnies (female donkey×male horse) and mules (female horse×male donkey) are sterile with few reports of equine fertile hybrids. The main cause of this sterility is thought to be a meiotic block to spermatogenesis and oogenesis. This study compared the developmental features of the testes and a histological analyses of spermatogenesis in a male hinny with those of a normal, fertile stallion and Jack donkey. Hinny testes showed a thicker tunica albuginea, fewer blood vessels and more connective tissue in the testis parenchyma than those of the stallion and Jack donkey...
June 2016: Asian-Australasian Journal of Animal Sciences
Charles H Adler, Brittany N Dugger, Joseph G Hentz, Michael L Hinni, David G Lott, Erika Driver-Dunckley, Shyamal Mehta, Geidy Serrano, Lucia I Sue, Amy Duffy, Anthony Intorcia, Jessica Filon, Joel Pullen, Douglas G Walker, Thomas G Beach
INTRODUCTION: Finding a peripheral tissue biopsy site to diagnose early PD would be of value for clinical care, biomarker validation, and as research enrollment criteria. Whereas autopsy and advanced PD studies suggest that the submandibular gland is an important biopsy site, there are no studies in early PD. The aim of this study was to determine whether needle biopsy of the submandibular gland reveals Lewy type alpha-synucleinopathy in early PD. METHODS: Twenty-five early PD (duration < 5 years) and 10 controls underwent transcutaneous needle core biopsies of the submandibular gland...
February 2016: Movement Disorders: Official Journal of the Movement Disorder Society
Nicholas L Deep, Dale C Ekbom, Michael L Hinni, Matthew A Zarka, Samir H Patel
OBJECTIVE: To report a single institutional series of high-grade neuroendocrine carcinoma of the larynx (NCL), a very rare yet aggressive tumor. To review the management of NCL, including discussion of clinical behavior, treatment outcome, and prognosis. METHOD: A retrospective chart review of high-grade laryngeal neuroendocrine carcinomas at a single institution, including small- and large-cell neuroendocrine carcinomas. A total of 8 patients with high-grade NCL treated at our institution from 1992 to 2014 were identified...
June 2016: Annals of Otology, Rhinology, and Laryngology
Kathryn M Van Abel, Nicole M Tombers, Kari A Krein, Eric J Moore, Daniel L Price, Jan L Kasperbauer, Michael L Hinni, David G Lott, Dale C Ekbom
OBJECTIVE: To prospectively analyze quality-of-life outcomes following transoral diverticulotomy with cricopharyngeal myotomy (DCPM) for Zenker's diverticulum (ZD). STUDY DESIGN: Prospective single-group study. SETTINGS: Tertiary academic institution. SUBJECTS AND METHODS: A prospective multicenter study performed from January 1, 2012, to July 1, 2014, included 18 patients presenting with ZD undergoing DCPM. Standardized questionnaires-including the 10-item Eating Assessment Tool (EAT-10), Functional Outcome of Swallowing Scale (FOSS), and the Reflux Symptom Index (RSI)-were completed preoperatively and at 3 and 6 months postoperatively...
February 2016: Otolaryngology—Head and Neck Surgery
Jane Bates
Hen, duck, dearie, hinny, love - these are just a selection of words we Brits use to express friendliness… words we get so used to hearing, we barely even register them.
October 21, 2015: Nursing Standard
Matthew Mors, Santino S Cervantes, Michael Hinni
We present the first bizarre parosteal osteochondromatous proliferation (BPOP) in the nasal dorsum. These lesions have been described since 1983; however, the vast majority of these lesions do not present in the head and neck, although five cases exist in the literature. An understanding of the potential sites for bizarre paraosteal osteochondromatous proliferations will help lead to successful diagnosis and proper treatment.
January 2015: Journal of Oral and Maxillofacial Pathology: JOMFP
Michael L Hinni, Thomas Nagel, Brittany Howard
PURPOSE OF REVIEW: This article reviews literature pertaining to squamous cell carcinoma (SCC) of the oropharynx and the evolution of transoral surgical (TOS) techniques for its management. Oncologists are recognizing a changing pattern in the cause of oropharyngeal cancer, namely the increasing incidence of HPV-associated tumors. An effort is underway to reduce the morbidity of treatment without jeopardizing survival. This is a timely discussion for reassessment of current standards of care and opening dialogue on treatment de-escalation...
April 2015: Current Opinion in Otolaryngology & Head and Neck Surgery
Alpen B Patel, Michael L Hinni, Taylor R Pollei, Richard E Hayden, Eric J Moore
OBJECTIVES: Alert the reader to the complication of severe dysphagia following transoral laser microsurgery (TLM) or transoral robotic surgery (TORS) for bilateral simultaneous or synchronous tonsillar squamous cell carcinoma. METHODS: A case series of four patients treated at an academic tertiary center between 2008 and 2012 is presented; two treated with transoral laser microsurgery and two with transoral robotic surgery for biopsy-proven untreated bilateral primary squamous cell carcinoma...
November 2015: European Archives of Oto-rhino-laryngology
Michael L Hinni, Alpen B Patel, Thomas H Nagel, Brittany E Howard
The objective is to describe an innovative laryngoscope developed to improve visualization, provide greater exposure, and enhance precision and success during transoral procedures. A retrospective review of 170 patients who underwent transoral surgery with a new distending laryngoscope was conducted. We compared and contrasted our exposure within the oropharynx, hypopharynx, and larynx using the laryngoscope with that of currently available instrumentation. Specific mechanical dimensions of the laryngoscope along with the provided working field were calculated...
May 2016: European Archives of Oto-rhino-laryngology
Samir H Patel, Richard E Hayden, Michael L Hinni, William W Wong, Robert L Foote, Shadi Milani, Qing Wu, Stephen J Ko, Michele Y Halyard
IMPORTANCE: The etiology and optimal treatment are unknown for angiosarcoma, an aggressive malignant tumor that affects vascular endothelial cells and can be mistaken for benign lesions such as hemangioma. OBJECTIVE: To determine the treatment outcomes of patients with angiosarcoma of the face or scalp treated with a combination of surgery, radiation therapy, and/or chemotherapy. DESIGN, SETTING, AND PARTICIPANTS: Retrospective study of 55 patients with angiosarcoma of the face or scalp treated between January 1, 1973, and December 31, 2012, at a tertiary-care academic medical institution...
April 2015: JAMA Otolaryngology—Head & Neck Surgery
Hans-J Welkoborsky, Sylvia Graß, Cordula Deichmüller, Oliver Bertram, Michael L Hinni
Orbital swelling in children presents diagnostic and therapeutic challenges. Most are associated with acute sinusitis with complicating factors possibly including: amaurosis, meningitis, intracranial abscess or even cavernous sinus thrombosis. However not all acute orbital swelling is associated with acute sinusitis. A careful evaluation is critical prior to initiating therapy. Clinical records of 49 children (27 girls, 22 boys, with an average age of 11.8 years) were retrospectively reviewed. Historical data evaluated included all available information from parents and previous treating physicians...
May 2015: European Archives of Oto-rhino-laryngology
Brittany E Howard, Eric J Moore, Michael L Hinni
OBJECTIVES: We report the clinical findings, surgical management, and outcomes for lingual thyroidectomy. METHODS: We performed a retrospective case review of lingual thyroidectomy performed at 3 tertiary-care academic referral centers between 1994 and 2012. RESULTS: Nine patients underwent lingual thyroidectomy for symptoms including globus sensation (6 patients), dysphagia (5 patients), and airway obstruction (5 patients). Before surgery, 3 patients had attempted medical suppressive therapy...
March 2014: Annals of Otology, Rhinology, and Laryngology
Andy M Courson, April M Landry, David G Lott, Michael L Hinni
OBJECTIVES: We demonstrate indications for external mechanical stapler diverticulectomy in the modern era of endoscopic treatment. We review treatment of a large diverticulum and discuss considerations that should be made in deciding on the type of surgical treatment. METHODS: The index case was in a 75-year-old man who had undergone open cricopharyngeal myotomy with diverticulopexy 35 years earlier. He presented with 25 years of recurrent symptoms. A swallow study showed a 6...
December 2013: Annals of Otology, Rhinology, and Laryngology
Samir H Patel, Nathan D Munson, David G Grant, Steven J Buskirk, Michael L Hinni, William C Perry, Robert L Foote, Rebecca B McNeil, Michele Y Halyard
OBJECTIVES: We evaluated relapse patterns after transoral laser microsurgery (TLM) in squamous cell carcinoma (SCC) of the tonsil and tongue base and evaluated the indications for adjuvant irradiation. METHODS: Between December 1, 1996, and December 31, 2005, 79 patients with previously untreated SCC of the tonsil or tongue base underwent TLM with or without neck dissection. Thirty-eight patients (48%) underwent postoperative irradiation (median, 62 Gy) to the primary site and the neck...
January 2014: Annals of Otology, Rhinology, and Laryngology
Hans-J Welkoborsky, Michael L Hinni, Hartmut Moebius, Lothar Bauer, Helmut Ostertag
OBJECTIVES: The histopathologic origin of iatrogenic subglottic tracheal stenosis (ISTS) remains unclear. The purpose of this study was to use detailed operative microscopy to systematically examine the operative en bloc specimens of patients with ISTS and to observe the histologic and morphological changes in the hopes that these observations will provide insight into the histopathologic origin of these devastating injuries. METHODS: The operative specimens of 18 patients who underwent open tracheal or laryngotracheal resection for ISTS were examined...
January 2014: Annals of Otology, Rhinology, and Laryngology
Alvaro Sanabria, Carl E Silver, Kerry D Olsen, Jesus E Medina, Marc Hamoir, Vinidh Paleri, Vanni Mondin, Alessandra Rinaldo, Juan P Rodrigo, Carlos Suárez, Carsten C Boedeker, Michael L Hinni, Luiz P Kowalski, Afshin Teymoortash, Jochen A Werner, Robert P Takes, Alfio Ferlito
Among patients with head and neck squamous cell carcinoma with a negative neck who are initially treated with (chemo)radiotherapy, a number of cases will recur locally without obvious neck recurrence. There is little information available as to the most efficacious management of the neck in these cases. We have reviewed the literature to see what conclusions can be drawn from previous reports. We conducted a bibliography search on MEDLINE and EMBASE databases. Studies published in the English language and those on squamous cell carcinoma of the oral cavity, nasopharynx, oropharynx, larynx and hypopharynx were included...
December 2014: European Archives of Oto-rhino-laryngology
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