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https://www.readbyqxmd.com/read/28514834/antitumor-activity-of-brazilian-red-propolis-fractions-against-hep-2-cancer-cell-line
#1
Caroline Olivieri da Silva Frozza, Denis Amilton Santos, Luciane Corbellini Rufatto, Luciane Minetto, Fernando Joel Scariot, Sergio Echeverrigaray, Claus Tröger Pich, Sidnei Moura, Francine Ferreira Padilha, Sibele Borsuk, Lucielli Savegnago, Tiago Collares, Fabiana Kömmling Seixas, Odir Dellagostin, Mariana Roesch-Ely, João Antonio Pêgas Henriques
Continuous increases in the rates of tumor diseases have highlighted the need for identification of novel and inexpensive antitumor agents from natural sources. In this study, we investigated the effects of enriched fraction from hydroalcoholic Brazilian red propolis extract against Hep-2 cancer cell line. Initially 201 fractions were arranged in 12 groups according to their chromatographic characteristics (A-L). After an in vitro cell viability screening, J and L were further selected as promising enriched fractions for this study...
May 13, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28513741/magneto-structural-correlations-in-a-family-of-di-alkoxo-bridged-chromium-dimers
#2
Hector W L Fraser, Gary S Nichol, Gunasekaran Velmurugan, Gopalan Rajaraman, Euan K Brechin
A series of di-alkoxo bridged Cr(iii) dimers have been synthesised using pyridine alcohol ligands. The structures fall into four general categories and are of formula: [Cr2(OMe)2(pic)4]·½MeOH·½Et2O (1), [Cr2(hmp)2(pic)2X2] (where X = Cl (2), Br (3)), [Cr2(L)2Cl4(A)2]·2S (where L = hmp, A = H2O and S = Et2O (4); L = hmp, A = pyridine and S = pyridine (5); L = hmp, A = 4-picoline and no S (6); L = hep, A = H2O and S = MeCN (7)), and [Cr(hmp)(hmpH)Cl2]·MeCN (8). Direct current (DC) magnetic susceptibility measurements show relatively weak antiferromagnetic exchange interactions between the Cr(iii) centres with J values <|15| cm(-1) in all of the complexes measured...
May 17, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28512032/cytotoxic-triterpene-diglycosides-from-the-sea-cucumber-stichopus-horrens
#3
Nguyen Xuan Cuong, Le Thi Vien, Le Hoang, Tran Thi Hong Hanh, Do Thi Thao, Nguyen Van Thanh, Nguyen Hoai Nam, Do Cong Thung, Phan Van Kiem, Chau Van Minh
Using various chromatographic separation techniques, eight triterpene diglycosides (1-8), including four new compounds namely stichorrenosides A-D (1-4), were isolated from a methanol extract of the Vietnamese sea cucumber S. horrens. Their structures were elucidated based on spectroscopic analyses, including HR ESI MS, 1D and 2D NMR. Their in vitro cytotoxic activity against five human cancer cell lines, Hep-G2 (hepatoma cancer), KB (epidermoid carcinoma), LNCaP (prostate cancer), MCF7 (breast cancer), and SK-Mel2 (melanoma), was evaluated using SRB methods...
May 6, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28508251/occlusion-of-a-long-term-transpleural-biliary-drainage-tract-using-a-gelatin-pledget-hep-plug-%C3%A2
#4
Nikolas Kortes, Daniel Gnutzmann, Philip Konietzke, Philipp Mayer, Migle Sumkauskaite, Hans-Ulrich Kauczor, Boris A Radeleff
This case describes a technique used to close a long-term 14F transpleural biliary drainage catheter tract to prevent biliopleural fistula and further complications. We deployed a compressed gelatin foam pledget provided in a pre-loaded delivery device (Hep-Plug™) along the intrahepatic tissue tract for sealing it against the pleural cavity. The device used is easy to handle and gives the Interventional Radiologist the possibility to safely manage and prevent complications after percutaneous transhepatic interventions...
May 15, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28505596/engineered-hydrogels-increase-the-post-transplantation-survival-of-encapsulated-hesc-derived-midbrain-dopaminergic-neurons
#5
Maroof M Adil, Tandis Vazin, Badriprasad Ananthanarayanan, Gonçalo M C Rodrigues, Antara T Rao, Rishikesh U Kulkarni, Evan W Miller, Sanjay Kumar, David V Schaffer
Cell replacement therapies have broad biomedical potential; however, low cell survival and poor functional integration post-transplantation are major hurdles that hamper clinical benefit. For example, following striatal transplantation of midbrain dopaminergic (mDA) neurons for the treatment of Parkinson's disease (PD), only 1-5% of the neurons typically survive in preclinical models and in clinical trials. In general, resource-intensive generation and implantation of larger numbers of cells are used to compensate for the low post-transplantation cell-survival...
May 5, 2017: Biomaterials
https://www.readbyqxmd.com/read/28502298/-forkhead-domain-inhibitor-6-fdi-6-increases-apoptosis-and-inhibits-invasion-and-migration-of-laryngeal-carcinoma-cells-by-down-regulating-nuclear-foxm1
#6
Yanan Liu, Lin Zhu, Taoyu Wen, Jie Wan, Yue Lei, Hongyan Chen
Objective To study the effects of new small molecular inhibitor, forkhead domain inhibitor-6 (FDI-6), on proliferation, apoptosis, invasion and migration in human laryngeal carcinoma Hep-2 cell line and the related mechanism. Methods MTT assay was used to test the proliferation rate of Hep-2 cells before and 12, 24 hours after treated with (5, 10, 20, 40, 80) μmol/L of FDI-6. Flow cytometry (FCM) and Transwell(TM) chamber assay were respectively carried out to detect the apoptosis rate, cell invasion and migration in Hep-2 cells after treated by 10, 20 μmol/L FDI-6 for 24 hours...
May 2017: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/28488579/evolutionary-cancer-favoring-engineered-vaccinia-virus-for-metastatic-hepatocellular-carcinoma
#7
So Young Yoo, Su-Nam Jeong, Dae Hwan Kang, Jeong Heo
Engineered vaccinia virus-based therapy shows promising results in patients with advanced hepatocellular carcinoma, although a strategic virus design for the metastatic liver and the study of its efficacy in treating the cancer has not been well assessed. In this paper, we proposed a simple and strategic virus design for targeting metastatic hepatocellular carcinoma. We developed an evolutionary cancer-favoring engineered vaccinia virus (CVV, which is produced by repeated selective replication in cancerous tissues and then deleting viral thymidine kinase genes) and investigated its therapeutic effects on metastatic liver cancer...
April 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/28488368/a-cluster-of-adenovirus-type-b55-infection-in-a-neurosurgical-inpatient-department-of-a-general-hospital-in-guangdong-china
#8
Lina Yi, LiRong Zou, Jing Lu, Min Kang, Yingchao Song, Juan Su, Xin Zhang, LiJun Liang, HanZhong Ni, Changwen Ke, Jie Wu
BACKGROUND: Human adenovirus type 55 is a re-emerging human respiratory pathogen that is associated with several respiratory infections outbreaks in military and school populations. In this study, we describe the first HAdV55-associated hospital outbreak documented in Guangdong, China. METHODS: Active surveillance was conducted in the involved neurosurgical inpatient department. All staff and patients in the involved neurosurgical department were surveyed for any symptoms of fever (≥38°C) and enlarged tonsils during the outbreak period...
May 10, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/28484706/endophytic-actinobacteria-associated-with-dracaena-cochinchinensis-lour-isolation-diversity-and-their-cytotoxic-activities
#9
Nimaichand Salam, Thi-Nhan Khieu, Min-Jiao Liu, Thu-Trang Vu, Son Chu-Ky, Ngoc-Tung Quach, Quyet-Tien Phi, Manik Prabhu Narsing Rao, Angélique Fontana, Samira Sarter, Wen-Jun Li
Dracaena cochinchinensis Lour. is an ethnomedicinally important plant used in traditional Chinese medicine known as dragon's blood. Excessive utilization of the plant for extraction of dragon's blood had resulted in the destruction of the important niche. During a study to provide a sustainable way of utilizing the resources, the endophytic Actinobacteria associated with the plant were explored for potential utilization of their medicinal properties. Three hundred and four endophytic Actinobacteria belonging to the genera Streptomyces, Nocardiopsis, Brevibacterium, Microbacterium, Tsukamurella, Arthrobacter, Brachybacterium, Nocardia, Rhodococcus, Kocuria, Nocardioides, and Pseudonocardia were isolated from different tissues of D...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28482570/heteroleptic-silver-i-complexes-with-2-2-6-2%C3%A2-terpyridines-and-naproxen-dna-interaction-egfr-vegfr2-kinase-growth-inhibition-and-cell-cycle-arrest-studies
#10
Dharmasivam Mahendiran, Raju Senthil Kumar, Aziz Kalilur Rahiman
A series of heteroleptic silver(I) complexes of the type [Ag(L(1-3))(nap)] (1-3), where L(1-3)=4'-(4-substituted)-2,2':6',2″-terpyridines and nap=naproxen have been synthesized and characterized by elemental analysis and spectroscopic methods. The geometric parameters of the complexes were determined using UV-Vis and DFT calculations together with the IR spectral data. All the complexes adopted distorted tetrahedral geometry around silver(I) ion. The small HOMO-LUMO energy gap supports the bioefficacy of the complexes...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28481172/clinical-decision-making-to-address-poor-outcomes-in-persistent-horizontal-semicircular-canal-benign-paroxysmal-positional-vertigo-a-case-study
#11
Brian M Moore
BACKGROUND: Horizontal semicircular canal BPPV (HSC-BPPV) can occur in 10-30% of BPPV cases. Lower success rates are reported for HSC-BPPV. The apogeotropic form of HSC-BPPV is more difficult to treat, as 5-40% of cases are described to be refractory to repositioning maneuvers. PURPOSE: To describe the assessment and treatment of a patient presenting with HSC-BPPV and to demonstrate the potential use of Forced-Prolonged Positioning (FPP) as a home exercise program (HEP) for persistent HSC-BPPV in an elderly patient...
May 8, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28473813/asunaprevir-evokes-hepatocytes-innate-immunity-to-restrict-the-replication-of-hepatitis-c-and-dengue-virus
#12
Wei-Lun Tsai, Jin-Shiung Cheng, Chih-Wen Shu, Kwok-Hung Lai, Hoi-Hung Chan, Chun-Ching Wu, Jing-Mei Wu, Ping-I Hsu, Raymond T Chung, Tsung-Hsien Chang
Type I Interferon-mediated innate immunity against Flaviviridae, such as Hepatitis C virus (HCV) and Dengue virus (DENV), involves TLR3, RIG-I-like receptor (RLR) and JAK-STAT signal pathways. Asunaprevir is a newly developed HCV protease inhibitor for HCV treatment. Whether, asunaprevir activates innate immunity to restrict viral infection is unclear. Thus, this study investigates the effect of asunaprevir on innate immunity and its influence on HCV and DENV infection. Huh 7.5.1, Hep-G2 cells, JFH-1 infection model, and DENV-2 infection were used for the analysis...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28466627/predictors-of-parents-adherence-to-home-exercise-programs-for-children-with-developmental-disabilities-regarding-both-exercise-frequency-and-duration-a-survey-design
#13
Francesc Medina-Mirapeix, Carmen Lillo-Navarro, Joaquina Montilla-Herrador, Mariano Gacto-Sanchez, María Á Franco-Sierra, Pilar Escolar-Reina
BACKGROUND: Many families have problems adhering to home exercise programs (HEP) for children with developmental disabilities. However, parental participation in HEP is known to have a positive effect on child-related outcome variables, as well as on parental functioning. AIM: This study examined whether the different behaviours of health professionals, and the behaviour and social characteristics of parents determine rates of parental adherence to both the frequency per week, and duration per session, of HEP for children with developmental disabilities attending paediatric services in early intervention centres...
May 2, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28465443/phase-i-and-preliminary-phase-ii-study-of-trc105-in-combination-with-sorafenib-in-hepatocellular-carcinoma
#14
Austin Duffy, Chi Ma, Susanna Ulahannan, Osama E Rahma, Oxana Makarova-Rusher, Liang Cao, Yunkai Yu, David Kleiner, Jane Trepel, Min-Jung Lee, Yusuke Tomita, Seth M Steinberg, Theo Heller, Baris Turkbey, Peter L Choyke, Cody J Peer, William D Figg, Bradford J Wood, Tim F Greten
Endoglin (CD105) is an endothelial membrane receptor expressed on tumor vasculature. Endoglin expression is induced by VEGF pathway inhibition. TRC105 is a chimeric IgG1 CD105 monoclonal antibody that inhibits angiogenesis, causes antibody-dependent cellular cytotoxicity (ADCC) and apoptosis of proliferating endothelium. <br /><br />Experimental Design: Patients with HCC (Childs Pugh A/B7), ECOG 0/1, were enrolled in a phase I study of TRC105 at 3, 6, 10, 15mg/kg q 2wks given with sorafenib 400mg bid...
May 2, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28465279/knowledge-attitude-behavior-and-practices-regarding-hiv-viral-hepatitis-and-sexually-transmitted-infections-among-migrants-from-sub-saharan-africa-living-in-germany-a-multicenter-survey-protocol
#15
Claudia Santos-Hövener, Carmen Koschollek, Anna Kuehne, Adama Thorlie, Viviane Bremer
BACKGROUND: Migration has an impact on the epidemiology of viral hepatitis B and C (HEP) and HIV in Germany; migrants from sub-Saharan Africa (MisSA) in Germany are disproportionally affected by HIV. In the last 10 years, a total of 10%-15% of all newly diagnosed HIV cases were among MisSA; 20%-30% of them acquired HIV in Germany. Prevalence of HEP among MisSA in Germany is unknown, but Western Africa, from where most MisSA in Germany originate, reports the highest prevalence of hepatitis B worldwide...
May 2, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28462910/optimum-silicon-doping-of-carbon-coatings-by-pulsed-laser-technique-for-superior-functional-biomedical-surfaces-fabrication
#16
Ion N Mihailescu, Dorota Bociaga, Gianina Popescu-Pelin, George Stan, Liviu Duta, Gabriel Socol, Carmen Chifiriuc, Coralia Bleotu, Veronica Lazar, Marius-Adrian Husanu, Irina Zgura, Florin Miculescu, Irina Negut, Claudiu Hapenciuc
We report on the fabrication of Silicon (Si) doped Carbon (C) [C:Si] structures by combinatorial pulsed laser deposition to identify the best design for a novel generation of multi-functional coated implants. The synthesized films were characterized from the morphological, structural, compositional, mechanical and microbiological points of view. Scanning Electron Microscopy investigation highlighted the presence, on top of the deposited layers, of spheroid particulates with sizes in the micron range. No micro-cracks or delaminations were observed...
May 2, 2017: Biofabrication
https://www.readbyqxmd.com/read/28460335/a-macrophage-activating-injectable-hydrogel-to-sequester-endogenous-growth-factors-for-in-situ-angiogenesis
#17
Yanxian Feng, Qiu Li, Dang Wu, Yiming Niu, Cheng Yang, Lei Dong, Chunming Wang
Biomaterials scaffolds designed for many regenerative applications are expected to support neo-vascularisation, which is now being hampered by two limitations - the instability of exogenous growth factors (GFs) that are delivered to promote angiogenesis; and the loss of extracellular matrix components that bind and stabilise GFs. Here, we report the design and evaluation of an injectable hydrogel system aimed at restoring a GF-binding microenvironment to enhance the pro-angiogenic functions of endogenous GFs...
April 25, 2017: Biomaterials
https://www.readbyqxmd.com/read/28458366/novel-polyfunctional-pyridines-as-anticancer-and-antioxidant-agents-synthesis-biological-evaluation-and-in-silico-adme-t-study
#18
Mona Hany Badr, Sherif Ahmed Fawzi Rostom, Mohammed Fouad Radwan
Two series of novel alkoxylated 2-oxo(imino)-3-pyridinecarbonitriles (structurally-relevant to some reported anticancer pyridines with phosphodiesterase 3A (PDE3A) inhibitory activity) were synthesized and evaluated for their in vitro differential tumor cell growth inhibitory potential against the breast MCF7, hepatocellular Hep-G2, colon CACO-2 cell lines, and a normal human foreskin fibroblast Hs27 cell line. Compounds 8, 16 and 19 displayed recognizable growth inhibitory ability and selectivity towards the breast MCF7 (LC50 19...
2017: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28458357/design-and-synthesis-of-new-anticancer-glycyrrhetinic-acids-and-oleanolic-acids
#19
Rui Wang, Qing-Xuan Zheng, Wei Wang, Ling Feng, Hui-Jing Li, Qi-Yong Huai
A series of new glycyrrhetinic acids and oleanolic acids has been designed and synthesized based on the principles of combinatorial chemical synthesis. Their anticancer activities were further studied by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method with hepatocellular carcinoma (Hep-G2), breast cancer (MCF-7) cell lines and a normal hepatic cell (LO2). Cytotoxicity tests (in vitro) indicated that compound 6a showed the highest cytotoxicity with the lowest IC50 values of 23...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28452948/chemical-composition-antioxidant-and-%C3%AE-glucosidase-inhibiting-activities-of-the-aqueous-and-hydroethanolic-extracts-of-vaccinium-myrtillus-leaves
#20
Kristina Bljajić, Roberta Petlevski, Lovorka Vujić, Ana Čačić, Nina Šoštarić, Jasna Jablan, Isabel Saraiva de Carvalho, Marijana Zovko Končić
Vaccinium myrtillus (bilberry) leaf is traditionally used in southeastern Europe for the treatment of diabetes. In the present study, the ability of bilberry leaf extracts to inhibit carbohydrate-hydrolyzing enzymes and restore glutathione concentration in Hep G2 cells subjected to glucose-induced oxidative stress was investigated. A comprehensive analysis of the antioxidant activity of two bilberry leaf extracts was performed. The aqueous extract showed excellent total antioxidant and chelating activity. Its antioxidant activity in the β-carotene-linoleic acid assay was very good, reaching the activity of the antioxidant standard BHA (93...
April 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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