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JOURNAL ARTICLE
Christian Hobeika, Maxime Ronot, Boris Guiu, Giovanna Ferraioli, Hiroko Iijima, Toshifumi Tada, Dong Ho Lee, Hidekatsu Kuroda, Young Hwan Lee, Jeong Min Lee, So Yeon Kim, Christophe Cassinotto, Laura Maiocchi, Ambra Raimondi, Takashi Nishimura, Takashi Kumada, Eun Young Kwon, Jong Keon Jang, Jean-Michel Correas, Dominique Valla, Valérie Vilgrain, Marco Dioguardi Burgio
BACKGROUND AND RATIONALE: Non-invasive tools assessing steatosis, such as ultrasonography-based 2D-attenuation imaging (ATI), are needed to tackle the worldwide burden of steatotic liver disease. This one-stage individual patient data (IPD) meta-analysis aimed to create an ATI-based steatosis grading system. MAIN RESULTS: A systematic review (EMBASE+MEDLINE, 2018-2022) identified studies, including patients with histologically or MRI-PDFF-verified ATI for grading steatosis (S0 to S3)...
April 23, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#2
JOURNAL ARTICLE
Naga Chalasani, Eduardo Vilar-Gomez, Rohit Loomba, Katherine P Yates, Anna Mae Diehl, Brent A Neuschwander-Tetri, Srinivasan Dasarathy, Kris V Kowdley, Norah Terrault, Laura A Wilson, James Tonascia, Arun Sanyal
BACKGROUND AND AIMS: The patatin-like phospholipase domain-containing protein 3 (PNPLA3) rs738409 variant is associated with Steatotic Liver Disease (SLD) and its progression. We examined the association between PNPLA3 and the development of major adverse liver outcomes (MALO) and how non-modifiable and modifiable conditions modify this relationship. APPROACH AND RESULTS: 2,075 adults with biopsy-confirmed Metabolic-Associated SLD (MASLD) were enrolled in the MASLD CRN studies and followed prospectively until death, transplant, or withdrawal of consent...
April 23, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#3
JOURNAL ARTICLE
A Jay Freeman, Michael R Narkewicz
No abstract text is available yet for this article.
April 23, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#4
JOURNAL ARTICLE
Laura Collignon, Kenn Holmbeck, Ashley Just, Lieven Verhoye, Rodrigo Velázquez-Moctezuma, Ulrik Fahnøe, Thomas H R Carlsen, Mansun Law, Jannick Prentoe, Troels K H Scheel, Judith M Gottwein, Philip Meuleman, Jens Bukh
BACKGROUND AIMS: HCV infection continues to be a major global health burden, despite effective antiviral treatments. The urgent need for a protective vaccine is hindered by the scarcity of suitable HCV permissive animal models tractable in vaccination and challenge studies. Currently, only antibody neutralization studies in infectious cell culture systems or studies of protection by passive immunization of human-liver chimeric mice offer the possibility to evaluate the effect of vaccine-induced antibodies...
April 23, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#5
JOURNAL ARTICLE
Yuki Hitomi, Kazuko Ueno, Yoshihiro Aiba, Nao Nishida, Michihiro Kono, Mitsuki Sugihara, Yosuke Kawai, Minae Kawashima, Seik-Soon Khor, Kazuhiro Sugi, Hirotaka Kouno, Hiroshi Kouno, Atsushi Naganuma, Satoru Iwamoto, Shinji Katsushima, Kiyoshi Furuta, Toshiki Nikami, Tomohiko Mannami, Tsutomu Yamashita, Keisuke Ario, Tatsuji Komatsu, Fujio Makita, Masaaki Shimada, Noboru Hirashima, Shiro Yokohama, Hideo Nishimura, Rie Sugimoto, Takuya Komura, Hajime Ota, Motoyuki Kojima, Makoto Nakamuta, Naoyuki Fujimori, Kaname Yoshizawa, Yutaka Mano, Hironao Takahashi, Kana Hirooka, Satoru Tsuruta, Takeaki Sato, Kazumi Yamasaki, Yuki Kugiyama, Yasuhide Motoyoshi, Tomoyuki Suehiro, Akira Saeki, Kosuke Matsumoto, Shinya Nagaoka, Seigo Abiru, Hiroshi Yatsuhashi, Masahiro Ito, Kazuhito Kawata, Akinobu Takaki, Kuniaki Arai, Teruko Arinaga, Masanori Abe, Masaru Harada, Makiko Taniai, Mikio Zeniya, Hiromasa Ohira, Shinji Shimoda, Atsumasa Komori, Atsushi Tanaka, Kazuyoshi Ishigaki, Masao Nagasaki, Katsushi Tokunaga, Minoru Nakamura
BACKGROUND AIMS: Previous genome-wide association studies (GWAS) have indicated the involvement of shared (population-non-specific) and non-shared (population-specific) susceptibility genes in the pathogenesis of primary biliary cholangitis (PBC) among European and East-Asian populations. Although a meta-analysis of these distinct populations has recently identified more than 20 novel PBC susceptibility loci, analyses of population-specific genetic architecture are still needed for a more comprehensive search for genetic factors in PBC...
April 23, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#6
JOURNAL ARTICLE
Ayaka Nomura, Yusuke Akamaru, Kentaro Nishida, Soichiro Mori, Akinobu Yasuyama, Masatoshi Nomura, Yukihiro Yoshikawa, Koki Tamai, Daisuke Takiuchi, Takuya Hamakawa, Mitsuyoshi Tei, Masanori Tsujie
A 77-year-old man presented to our hospital with a chief complaint of stomachache. He received a diagnosis of unresectable advanced gastric cancer classified as cT3, N+, M1(LYM, HEP, OSS), Stage ⅣB. He underwent first-line chemotherapy with SOX, second-line treatment with PTX plus Ram, and third-line treatment with nivolumab. The primary tumor showed a reduction in size, and liver and lymph node metastases were not detectable. However, after 5 years of chemotherapy, a re- enlargement was observed in the primary gastric lesion without progression of liver and lymph node metastases...
April 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
#7
JOURNAL ARTICLE
Tetsushi Nakagawa, Yuji Yamamoto, Senichiro Yanagawa, Shohei Shiozaki, Yuuki Kaneko, Atsuhiro Watanabe, Mai Nishina, Daisuke Takei, Yusuke Sumi, Minoru Yamaki, Manabu Kurayoshi, Junji Hashizume, Akihiko Oshita, Masahiro Nakahara, Toshio Noriyuki
A 67-year-old man visited our hospital for epigastric pain. Esophagogastroduodenoscopy(EGD)revealed type 2 gastric cancer from the cardia to the gastric angle, and histopathological examination revealed papillary adenocarcinoma(pap), HER2-positive. Contrast-enhanced CT showed wall thickening mainly in the posterior wall of the gastric body, enlarged lymph nodes that were lumped together with the main lesion, and 8 low-absorption areas with ring shaped contrast effects in both lobes of the liver. The patient was diagnosed as gastric cancer cT4aN(+)M1[HEP], clinical Stage ⅣB...
April 2024: Gan to Kagaku Ryoho. Cancer & Chemotherapy
#8
JOURNAL ARTICLE
Jiahao Du, Xiaoting Zhang, Wenlong Li, Miao Wang, Xi Zhou, Lei Ren
Blood-contacting catheters play a pivotal role in contemporary medical treatments, particularly in the management of cardiovascular diseases. However, these catheters exhibit inappropriate wettability and lack antimicrobial characteristics, which often lead to catheter-related infections and thrombosis. Therefore, there is an urgent need for blood contact catheters with antimicrobial and anticoagulant properties. In this study, we employed tannic acid (TA) and 3-aminopropyltriethoxysilane (APTES) to create a stable hydrophilic coating under mild conditions...
April 19, 2024: ACS Biomaterials Science & Engineering
#9
JOURNAL ARTICLE
Fredrik Åberg, Z Gordon Jiang, Helena Cortez-Pinto, Ville Männistö
Alcohol-associated liver disease (ALD), as highlighted in this narrative review, is a major public health concern, increasingly impacting global disease burden and premature mortality. In 2019, ALD accounted for the loss of 11 million life-years worldwide. The rising number of deaths and disability-adjusted life years attributed to ALD, particularly pronounced in America, are alarming. Projections suggest that the economic impact of ALD, as seen in the United States, could potentially double by 2040. ALD is increasingly prevalent among younger adults and has become the leading cause for liver transplantation in both America and Europe...
April 19, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#10
JOURNAL ARTICLE
Meng-Fei Wang, Tian-Ze Li, Yun-Bao Ma, Wen-Jing Ma, Yong-Cui Wang, Feng-Jiao Li, Ji-Jun Chen
Artemyriantholides A-K (1-11) as well as 14 known compounds (12-25) were isolated from Artemisia myriantha var. pleiocephala (Asteraceae). The structures and absolute configuration of compounds 2 and 8-9 were confirmed by the single crystal X-ray diffraction analyses, and the others were elucidated by MS, NMR spectral data and electronic circular dichroism calculations. All compounds were chemically characterized as guaiane-type sesquiterpenoid dimers (GSDs). Compound 1 was the first example of the GSD fused via C-3/C-11' and C-5/C-13' linkages, and compounds 2 and 5 were rare GSDs containing chlorine atoms...
April 16, 2024: Phytochemistry
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JOURNAL ARTICLE
Tianchun Wu, Han Yang, Jinjin Li, Hongbo Fang, Xiaoyi Shi, Jie Li, Liushun Feng
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths. However, the HCC treatment is still challenging. Herein, we aimed to reveal the anti-tumor effect of Jolkinolide B in HCC cell lines Huh-7 and SK-Hep-1. The results showed that Jolkinolide B inhibited the migration, invasion, and epithelial-to-mesenchymal transition(EMT) of HCC cells. In addition, Jolkinolide B induced HCC cell apoptosis by upregulating Bax and downregulating BCL-2 expressions. Furthermore, we demonstrated that Jolkinolide B inactivated the β-catenin signaling and reduced Musashi-2 expression...
2024: PloS One
#12
JOURNAL ARTICLE
Chengnan Guo, Zhenqiu Liu, Hong Fan, Haili Wang, Xin Zhang, Shuzhen Zhao, Yi Li, Xinyu Han, Tianye Wang, Xingdong Chen, Tiejun Zhang
BACKGROUND AND AIMS: The liver cirrhosis complications occur after long asymptomatic stages of progressive fibrosis and are generally diagnosed late. We aimed to develop a plasma metabolomic-based score tool to predict these events. APPROACH AND RESULTS: We enrolled 64,005 UK biobank participants with metabolomic profile. Participants were randomly divided into the training (n=43,734) and validation cohorts (n=20,271). Liver cirrhosis complications were defined as hospitalization for liver cirrhosis or presentation with hepatocellular carcinoma...
April 17, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#13
JOURNAL ARTICLE
Yu Jun Wong, Vincent L Chen, Asim Abdulhamid, Giulia Tosetti, Huttakan Navadurong, Apichat Kaewdech, Jessica Cristiu, Michael Song, Pooja Devan, Kai Le Ashley Tiong, Jean Ee Neo, Thaninee Prasoppokakorn, Pimsiri Sripongpun, Catherine Ann Malcolm Stedman, Sombat Treeprasertsuk, Massimo Primignani, Jing Hieng Ngu, Juan G Abraldes
INTRODUCTION: The utility of serial liver stiffness measurements (LSM) to predict decompensation in compensated advanced chronic liver disease (cACLD) patients remains unclear. We aimed to validate whether comparing serial LSM is superior to using the current LSM to predict liver-related events (LRE) in cACLD patients. METHODS: In this retrospective analysis of an international registry, cACLD patients with serial LSM were followed up until index LRE. We compared the performance of both the dynamic LSM changes and the current LSM (LSMc ) in predicting LRE using Cox-regression analysis, considering time zero of follow-up as the date of LSMc...
April 17, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#14
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
May 1, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#15
JOURNAL ARTICLE
Younis Hazari, Eric Chevet, Béatrice Bailly-Maitre, Claudio Hetz
Hepato-cellular carcinoma (HCC) is the most frequent primary liver cancer with an extremely poor prognosis and often develops on preset of chronic liver diseases. Major risk factors for HCC include metabolic dysfunction-associated steatohepatitis (MASH), a complex multifactorial condition associated with abnormal endoplasmic reticulum (ER) proteostasis. To cope with ER stress, the unfolded protein response (UPR) engages adaptive reactions to restore the secretory capacity of the cell. Recent advances revealed that ER stress signaling plays a critical role in HCC progression...
April 16, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#16
JOURNAL ARTICLE
Andrea Zaccaro, Francesca Della Penna, Elena Mussini, Eleonora Parrotta, Mauro Gianni Perrucci, Marcello Costantini, Francesca Ferri
Respiration and cardiac activity intricately interact through complex physiological mechanisms. The heartbeat-evoked potential (HEP) is an EEG fluctuation reflecting the cortical processing of cardiac signals. We recently found higher HEP amplitude during exhalation than inhalation during a task involving attention to cardiac sensations. This may have been due to reduced cardiac perception during inhalation and heightened perception during exhalation through attentional mechanisms. To investigate relationships between HEP, attention, and respiration, we introduced an experimental setup that included tasks related to cardiac and respiratory interoceptive and exteroceptive attention...
April 19, 2024: IScience
#17
JOURNAL ARTICLE
Jin-Zhen Jian, Tian-Qiong Lang, Wei Zhang, Yun-Qian Feng, Guo-Yong Luo
Various separation methods in combination with spectral data analysis, X-ray single crystal diffraction analysis, and litera-ture data comparison were employed to clarify the chemical constituents of Itea yunnanensis. Seven compounds were obtained from I. yunnanensis, which were identified as(S)-3-[1-(4-hydroxyphenyl)propane-2-yl]-4-methoxybenzoate methyl ester(1), iteafuranal B(2), syringaresinol(3), dihydrokaempferol(4), trimethoxybenzene(5), eicosane(6), and nonacosane(7), respectively. Among them, compound 1 was a new nor-neolignan compound named iteanorneoligan A, and the rest of the compounds were identified from I...
March 2024: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
#18
JOURNAL ARTICLE
Sara Krawczyk, Sylwia Golba, Cristina Neves, João Tedim
Nowadays, drug delivery systems (DDSs) are gaining more and more attention. Conducting polymers (CPs) are efficiently used for DDS construction as such systems can be used in therapy. In this research, a well-known CP, polypyrrole (PPy), was synthesized in the presence of the polysaccharide heparin (HEP) and chlorpromazine (CPZ) using sodium dodecyl sulfate (SDS) as electrolyte on a steel substrate. The obtained results demonstrate the successful incorporation of CPZ and HEP into the polymer matrix, with the deposited films maintaining stable electrochemical parameters across multiple doping/dedoping cycles...
March 29, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#19
JOURNAL ARTICLE
Winston Dunn, Yanming Li, Ashwani K Singal, Douglas A Simonetto, Luis A Díaz, Francisco Idalsoaga, Gustavo Ayares, Jorge Arnold, María Ayala-Valverde, Diego Perez, Jaime Gomez, Rodrigo Escarate, Eduardo Fuentes-López, Carolina Ramirez-Cadiz, Dalia Morales-Arraez, Wei Zhang, Steve Qian, Joseph C Ahn, Seth Buryska, Heer Mehta, Nicholas Dunn, Muhammad Waleed, Horia Stefanescu, Andreea Bumbu, Adelina Horhat, Bashar Attar, Rohit Agrawal, Joaquín Cabezas, Victor Echavaría, Berta Cuyàs, Maria Poca, German Soriano, Shiv K Sarin, Rakhi Maiwall, Prasun K Jalal, Fátima Higuera-de-la-Tijera, Anand V Kulkarni, P Nagaraja Rao, Patricia Guerra-Salazar, Lubomir Skladaný, Natália Kubánek, Veronica Prado, Ana Clemente-Sanchez, Diego Rincon, Tehseen Haider, Kristina R Chacko, Gustavo A Romero, Florencia D Pollarsky, Juan C Restrepo, Luis G Toro, Pamela Yaquich, Manuel Mendizabal, Maria L Garrido, Sebastián Marciano, Melisa Dirchwolf, Victor Vargas, César Jiménez, David Hudson, Guadalupe García-Tsao, Guillermo Ortiz, Juan G Abraldes, Patrick S Kamath, Marco Arrese, Vijay H Shah, Ramon Bataller, Juan P Arab
BACKGROUND AIMS: Alcohol-associated hepatitis (AH) poses significant short-term mortality. Existing prognostic models lack precision for 90-day mortality. Utilizing artificial intelligence (AI) in a global cohort, we sought to derive and validate an enhanced prognostic model. APPROACH AND RESULTS: The Global AlcHep initiative, a retrospective study across 23 centers in 12 countries, enrolled AH patients per NIAAA criteria. Centers were partitioned into derivation (11 centers, 860 patients) and validation cohorts (12 centers, 859 patients)...
April 12, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#20
JOURNAL ARTICLE
Won-Mook Choi, Young-Suk Lim
No abstract text is available yet for this article.
April 12, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
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