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https://www.readbyqxmd.com/read/29228028/a-novel-indel-variant-in-ldlr-responsible-for-familial-hypercholesterolemia-in-a-chinese-family
#1
Hongyan Shu, Jingwei Chi, Jing Li, Wei Zhang, Wenshan Lv, Jie Wang, Yujie Deng, Xu Hou, Yangang Wang
Familial hypercholesterolemia (FH) is an inherited disorder characterized by elevation of serum cholesterol bound to low-density lipoprotein. Mutations in LDLR are the major factors responsible for FH. In this study, we recruited a four-generation Chinese family with FH and identified the clinical features of hypercholesterolemia. All affected individuals shared a novel indel mutation (c.1885_1889delinsGATCATCAACC) in exon 13 of LDLR. The mutation segregated with the hypercholesterolemia phenotype in the family...
2017: PloS One
https://www.readbyqxmd.com/read/29227214/human-reliability-assessment-in-a-99mo-99mtc-generator-production-facility-by-using-standardized-plant-analysis-risk-human-spar-h-technique
#2
Meysam Eyvazlou, Ali Dadashpour Ahangar, Azin Rahimi, Mohammad Reza Davarpanah, Seyed Soheil Sayyahi, Mehdi Mohebali
INTRODUCTION: Reducing human error is an important factor for enhancing safety protocols in various industries. Hence, the analysis of the likelihood of human error in nuclear industries such as radiopharmaceutical production facilities has become more essential. METHODS: This cross-sectional descriptive study was conducted to quantify the probability of human errors in a 99Mo/99mTc generator production facility in Iran. First, through expert interviews, the production process of 99Mo/99mTc generator was analyzed using hierarchical task analysis (HTA) method...
December 11, 2017: International Journal of Occupational Safety and Ergonomics: JOSE
https://www.readbyqxmd.com/read/29226125/stattic-enhances-radiosensitivity-and-reduces-radio-induced-migration-and-invasion-in-hcc-cell-lines-through-an-apoptosis-pathway
#3
Gang Xu, Lihua Zhu, Yan Wang, Yawei Shi, Aihua Gong, Chaoyang Wu
Purpose: Signal transducer and activator of transcription factor 3 (STAT3) is involved in tumorigenesis, development, and radioresistance of many solid tumors. The aim of this study is to investigate the effects of stattic (an inhibitor of STAT3) on the radiosensitivity and radio-induced migration and invasion ability in hepatocellular carcinoma (HCC) cell lines. Methods: HCC cells were treated with stattic, and cell survival rate was analyzed through CCK-8 assay...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29225771/methylation-mediated-gadd45%C3%AE-enhanced-the-chemosensitivity-of-hepatocellular-carcinoma-by-inhibiting-the-stemness-of-liver-cancer-cells
#4
Xiao-Juan Hou, Qiu-Dong Zhao, Ying-Ying Jing, Zhi-Peng Han, Xue Yang, Li-Xin Wei, Yu-Ting Zheng, Feng Xie, Bai-He Zhang
Background: Defects of the growth arrest DNA damage-inducible gene 45β (Gadd45β) play an important role in the progression of tumor and confer resistance to chemotherapy. However, the role of Gadd45β in the apoptosis of hepatocellular carcinoma is still not clear. Purpose of this study was to explore the effect of Gadd45β on the apoptosis of liver cancer cells, and the possible mechanism was examined. Result: In this study, we first confirmed the decreased expression of Gadd45β in human liver cancer tissues and human liver cancer cell lines, when compared to the peri-tumor liver tissue and normal liver cells...
2017: Cell & Bioscience
https://www.readbyqxmd.com/read/29225629/synthesis-sar-and-docking-studies-disclose-2-arylfuran-1-4-naphthoquinones-as-in-vitro-antiplasmodial-hits
#5
Tatiane Freitas Borgati, Maria Fernanda Alves do Nascimento, Juma Fortunato Bernardino, Lunamaura Claudia Oliveira Martins, Alex Gutterres Taranto, Alaíde Braga de Oliveira
A total of 28 lapachol-related naphthoquinones with four different scaffolds were synthesized and spectroscopically characterized. In vitro antiplasmodial activity was assayed against the chloroquine-resistant Plasmodium falciparum W2 strain by the parasite lactate dehydrogenase (pLDH) method. Cytotoxicity against Hep G2A16 cell was determined by the MTT assay. All compounds disclosed higher in vitro antiplasmodial activity than lapachol. Ortho- and para-naphthoquinones with a furan ring fused to the quinonoid moiety were more potent than 2-hydroxy-3-(1'-alkenyl)-1,4-naphthoquinones, while ortho-furanonaphthoquinones were more cytotoxic...
2017: Journal of Tropical Medicine
https://www.readbyqxmd.com/read/29220868/incidence-and-prevalence-of-hepatitis-b-in-patients-with-diabetes-mellitus-in-the-uk-a-population-based-cohort-study-using-the-uk-clinical-practice-research-datalink
#6
Germano L C Ferreira, Cinzia Marano, Laurence De Moerlooze, Adrienne Guignard, Yang Feng, Yassine El Hahi, Tjeerd van Staa
We assessed the incidence and prevalence of hepatitis B (Hep B) in patients with or without diabetes mellitus using the UK Clinical Practice Research Datalink. This was a retrospective, observational study of diabetic and non-diabetic cohorts aged 0-80 years using Clinical Practice Research Datalink (NCT02324218). Incidence rates (IR) for each cohort were calculated. Crude and adjusted (Poisson Regression) IR ratios (IRR) were estimated with 95% confidence intervals (CI) to compare the cohorts. Hep B prevalence stratified by age, and hospitalisation related to Hep B were also calculated...
December 8, 2017: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/29218775/comparative-proteomic-analysis-of-silver-nanoparticle-effects-in-human-liver-and-intestinal-cells
#7
Albert Braeuning, Axel Oberemm, Josephine Görte, Linda Böhmert, Sabine Juling, Alfonso Lampen
Consumers are orally exposed to nanoparticulate or soluble species of the non-essential element silver due to its use in food contact materials or as a food additive. Potential toxicity of silver nanoparticles has gained special scientific attention. A fraction of ingested ionic or particulate silver is taken up in the intestine and transported to the liver, where it may induce oxidative stress and elicit subsequent adverse responses. Here, we present a comprehensive analysis of global proteomic changes induced in human Hep G2 hepatocarcinoma cells by different concentrations of AgPURE silver nanoparticles or by corresponding concentrations of ionic silver...
December 7, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/29215360/viruses-in-the-environment-presence-and-diversity-of-bacteriophage-and-enteric-virus-populations-in-the-umhlangane-river-durban-south-africa
#8
Veronna Marie, Johnson Lin
Due to the continued persistence of waterborne viral-associated infections, the presence of enteric viruses is a concern. Notwithstanding the health implications, viral diversity and abundance is an indicator of water quality declination in the environment. The aim of this study was to evaluate the presence of viruses (bacteriophage and enteric viruses) in a highly polluted, anthropogenic-influenced river system over a 6-month period at five sampling points. Cytopathic-based tissue culture assays revealed that the isolated viruses were infectious when tested on Hep-G2, HEK293 and Vero cells...
October 2017: Journal of Water and Health
https://www.readbyqxmd.com/read/29207661/immunization-with-recombinant-rabies-virus-expressing-interleukin-18-exhibits-enhanced-immunogenicity-and-protection-in-mice
#9
Weiwei Gai, Wenwen Zheng, Chong Wang, Gary Wong, Yanyan Song, Xuexing Zheng
Several studies have shown that interleukin-18 (IL-18) plays an important role in both innate and adaptive immune responses. In this study, we investigated the pathogenicity and immunogenicity of recombinant rabies virus expressing IL-18 (rHEP-IL18). Experimental results showed that Institute of Cancer Research (ICR) mice that received a single intramuscular immunization with rHEP-IL18 elicited the highest titers of serum neutralizing antibodies and the strongest cell-mediated immune responses to prevent the development of rabies disease, compared with immunization with the parent virus HEP-Flury...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29206708/use-of-a-telehealth-system-to-enhance-a-home-exercise-program-for-a-person-with-parkinson-disease-a-case-report
#10
Charlotte A Chatto, Paul T York, Catherine P Slade, Scott M Hasson
BACKGROUND AND PURPOSE: This case addresses feasibility of a home-based telehealth system to enhance home exercise program (HEP) adherence for a patient with Parkinson disease (PD). We describe START-System for Technology-Augmented Rehabilitation and Training-and discuss outcomes after integrating START into the HEP component of an established therapy protocol, Lee Silverman Voice Technique BIG (LSVT BIG). CASE DESCRIPTION: The participant was a 67-year-old woman with PD at Hoehn and Yahr Stage II...
December 1, 2017: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/29204090/autoantibodies-c-reactive-protein-erythrocyte-sedimentation-rate-and-serum-cytokine-profiling-in-monitoring-of-early-treatment
#11
Edyta Brzustewicz, Izabella Henc, Agnieszka Daca, Maria Szarecka, Malgorzata Sochocka-Bykowska, Jacek Witkowski, Ewa Bryl
Introduction: Currently used clinical scale and laboratory markers to monitor patients with early rheumatoid arthritis (RA) seem to be not sufficient. It has been demonstrated that disease- related cytokines may be elevated very early in RA development and cytokines are considered as the biomarkers potentially useful for RA monitoring. Material and methods: The group of patients with undifferentiated arthritis (UA) developing RA (UA→RA) was identified from a total of 121 people with arthralgia...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29202212/nebulized-heparin-attenuates-pulmonary-coagulopathy-and-inflammation-through-alveolar-macrophages-in-a-rat-model-of-acute-lung-injury
#12
Laura Chimenti, Marta Camprubí-Rimblas, Raquel Guillamat-Prats, Maria Nieves Gomez, Jessica Tijero, Lluis Blanch, Antonio Artigas
Objective Alveolar macrophages play a key role in the development and resolution of acute respiratory distress syndrome (ARDS), modulating the inflammatory response and the coagulation cascade in lungs. Anti-coagulants may be helpful in the treatment of ARDS. This study investigated the effects of nebulized heparin on the role of alveolar macrophages in limiting lung coagulation and inflammatory response in an animal model of acute lung injury (ALI). Methods Rats were randomized to four experimental groups...
November 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29200263/phenylboronic-acid-templated-gold-nanoclusters-for-mucin-detection-using-a-smartphone-based-device-and-targeted-cancer-cell-theranostics
#13
Deepanjalee Dutta, Sunil Kumar Sailapu, Arun Chattopadhyay, Siddhartha Sankar Ghosh
A phenylboronic acid templated gold nanocluster probe was developed to detect biomarker mucin by non-invasive fluorescence based method using a point of care smartphone based fluorescence detection device. The gold nanocluster probe is able to detect mucin specifically. The same probe was applied for in vitro targeted bio-imaging of HeLa and Hep G2 cancer cells and it demonstrated specific therapeutic effects towards cancer cells as well as multicellular tumor spheroids imparting theranostic property. The module is found to be more effective towards HeLa cells and pathway of cell death was established using flow cytometry based assays...
December 4, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29199881/phytochylomicron-as-a-dual-nanocarrier-for-liver-cancer-targeting-of-luteolin-in-vitro-appraisal-and-pharmacodynamics
#14
Yosra Sr Elnaggar, Manal A Elsheikh, Ossama Y Abdallah
AIM: A novel luteolin (LUT) loaded dual bionanocarrier 'phytochylomicron' was elaborated to allow LUT injectable delivery and liver cancer targeting. METHODS: LUT-phospholipid complex was prepared and loaded into chylomicron nanocarrier. Then phytochylomicron underwent physicochemical characterization, cell culture and pharmacodynamics studies on a new liver-tumor model. RESULTS: Phytochylomicron showed sustained release pattern with minimum drug leakage until reaching the liver...
December 4, 2017: Nanomedicine
https://www.readbyqxmd.com/read/29199584/anti-inflammation-and-lipogenic-inhibition-of-taiwanofungus-salmonea-mycelium-and-grifola-frondosa-fruiting-body
#15
Rao-Chi Chien, Yi-Chi Yang, Eric Icheng Lai, Jeng-Leun Mau
A long-term inflammatory response can cause the development of nonalcoholic steatohepatitis (NASH), which is mainly caused by abnormal metabolism of lipids in the liver. Taiwanofungus salmonea and Grifola frondosa, which are valuable medicinal mushrooms in Taiwan and exhibit many beneficial bioactivities, are used to evaluate effects on immune regulation in Raw 264.7 cells and on NASH-related responses in Hep G2 cells. According to the results, the production of proinflammatory cytokines was effectively decreased, whereas the production of interleukin-10 was increased...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29199553/apoptotic-effect-of-taiwanofungus-salmoneus-agaricomycetes-mycelia-and-solid-state-fermented-products-on-cancer-cells
#16
Rao-Chi Chien, Yu-Chieh Lin, Jeng-Leun Mau
Because of the high incidence of and high mortality rates associated with cancer, effective therapy for cancer is currently an imperative issue. Taiwanofungus salmoneus, a medicinal mushroom indigenous to Taiwan, has been demonstrated to exhibit various physiological activities and harmless effects. The bioactive compounds and anticancer abilities of T. salmoneus mycelia and fermented products were evaluated in this study. Total phenols, flavonoids, and ergothioneine were detected in mycelia and fermented products, and the amount of ergothioneine was evaluated in buckwheat (56...
2017: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/29194939/management-of-drug-interactions-with-direct-acting-antivirals-in-dutch-hiv-hepatitis-c-virus-coinfected-patients-adequate-but-not-perfect
#17
E J Smolders, C Smit, Ctmm de Kanter, Asm Dofferhoff, J E Arends, K Brinkman, B Rijnders, M van der Valk, P Reiss, D M Burger
OBJECTIVES: Direct-acting antivirals (DAAs) for treatment of chronic hepatitis C virus (HCV) infection can cause drug-drug interactions (DDIs) with combination antiretroviral therapy (cART) and non-cART co-medication. We mapped how physicians manage DDIs between DAAs and co-medication and analysed treatment outcomes. METHODS: Data were prospectively collected as part of the ATHENA HIV observational cohort and retrospectively analysed. Dutch patients with HIV/HCV coinfection who initiated treatment with DAAs between January 2015 and May 2016 were included...
December 1, 2017: HIV Medicine
https://www.readbyqxmd.com/read/29190910/the-tissue-distribution-and-significance-of-b7-h4-in-laryngeal-carcinoma
#18
Lili Chen, Meihua Jin, Chunshi Li, Yongjun Shang, Qinggao Zhang
The costimulatory signals CD28 and B7 have been shown to control tumor invasion and metastasis by regulating T cell activation, whereas the distribution characteristics of B7-associated proteins in laryngeal carcinoma (LC) tissue are still unclear. Here, the expression of members of the B7 superfamily, including B7-H1 (PD-L1), B7-DC (PD-L2) and B7-H4, in fifty-two LC samples was determined by immunohistochemistry, and the relationship between B7-H4 and epithelial-mesenchymal transition (EMT)-associated markers was further assessed by immunofluorescence double staining...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29188757/folate-receptor-targeted-multimodal-fluorescence-mesosilica-nanoparticles-for-imaging-delivery-palladium-complex-and-in-vitro-g-quadruplex-dna-interaction
#19
Marziyeh Poshteh Shirani, Behzad Rezaei, Taghi Khayamian, Mohammad Dinari, Kazem Karami, Zohreh Mehri-Lighvan, Fazileh Hosseini Shamili, Mohammd Ramezani, Mona Alibolandi
New folic acid-conjugated mesoporous silica nanoparticles were synthesized. The effect of calcination at 400°C on the fluorescence characteristics of mesoporous silica nanoparticles was studied in this work. The formed carbon dots (CDs) from calcination was used as the source of fluorescence. 3-Aminopropyltriethoxysilane was then used to amine-functionalized the fluorescent surface of mesoporous silica nanoparticles. The amine fluorescence mesoporous silica nanoparticles (amine-FMSNs) were coupled with folic acid (FA) as the target ligand (FA-amine-FMSNs)...
November 30, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29186980/overexpressed-mir-128a-enhances-chemoradiotherapy-to-laryngeal-cancer-cells-and-its-correlation-with-bmi1
#20
Hui Chen, Lei Jin, Liang Zhou, Jia-Meng Huang
AIM: To clarify the function of miR-128a on radiotherapy and chemotherapy resistance in laryngeal cancer and explore the possible mechanism. MATERIALS & METHODS: Hep-2 and AMC-HN-8 cell lines were cultured. MiR-128a was upregulated utilizing lentiviral transfection. Through radiotherapy and chemotherapy assays, the function of miR-128a on chemoradiotherapy was evaluated. The correlation of miR-128a with BMI1 was identified by performing real-time PCR. RESULTS: The hsa-miR128a cell line was established...
November 30, 2017: Future Oncology
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