keyword
https://read.qxmd.com/read/38192052/the-diagnosis-of-asbestosis-in-the-21-st-century-a-clinicopathological-correlation-of-102-cases
#21
JOURNAL ARTICLE
John M Carney, Thomas A Sporn, Victor L Roggli, Elizabeth N Pavlisko
Asbestosis, defined as diffuse pulmonary fibrosis caused by inhalation of asbestos fibers, occurs after heavy exposures to asbestos dust over several decades. Because workplace exposures have been significantly curtailed since the banning of asbestos in insulation products, we were interested in examining the clinicopathological characteristics of cases diagnosed in the 21st century. The consultation files of one of the authors (VLR) were reviewed for cases of asbestosis diagnosed since 1/1/2001. 102 cases were identified, with a median age of 75 years (range: 45-89)...
January 8, 2024: Ultrastructural Pathology
https://read.qxmd.com/read/38174880/pyonephrosis-complicated-with-spontaneous-intraperitoneal-rupture-and-diffuse-peritonitis-case-report-and-literature-review
#22
JOURNAL ARTICLE
Andrej Nikolovski, Shqipe Misimi, Nadica Draskacheva, Nimetula Limani
Pyonephrosis is a serious condition that can lead to kidney dysfunction, loss of the organ, and even fatal end due to its complications. The underlying etiologic factors include lithiasis, recurrent urinary infections, ureter stricture, ureteropelvic junction obstruction, malignancy, and retroperitoneal fibrosis. One of the rare possible complications of pyonephrosis is a retroperitoneal rupture with spontaneous communication to the abdomen causing secondary peritonitis. We present such a case which is the first video-documented report of the peritoneal rupture site within the abdominal cavity...
January 4, 2024: Clinical Nephrology
https://read.qxmd.com/read/38172378/the-disruptor-of-telomeric-silencing-1-like-dot1l-promotes-peritoneal-fibrosis-through-the-upregulation-and-activation-of-protein-tyrosine-kinases
#23
JOURNAL ARTICLE
Min Tao, Yingfeng Shi, Hui Chen, Jinqing Li, Yi Wang, Xiaoyan Ma, Lin Du, Yishu Wang, Xinyu Yang, Yan Hu, Xun Zhou, Qin Zhong, Danying Yan, Andong Qiu, Shougang Zhuang, Na Liu
The disruptor of telomeric silencing 1-like (DOT1L), a specific histone methyltransferase that catalyzed methylation of histone H3 on lysine 79, was associated with the pathogenesis of many diseases, but its role in peritoneal fibrosis remained unexplored. Here, we examined the role of DOT1L in the expression and activation of protein tyrosine kinases and development of peritoneal fibrosis. We found that a significant rise of DOT1L expression in the fibrotic peritoneum tissues from long-term PD patients and mice...
January 4, 2024: Mol Biomed
https://read.qxmd.com/read/38149395/-protective-effect-of-metformin-on-pulmonary-fibrosis-caused-by-paraquat-through-activating-amp-activated-protein-kinase-pathway
#24
JOURNAL ARTICLE
Tongying Liu, Lihong Gao, Jianhong Wang, Liaozhang Wu, Manhong Zhou
OBJECTIVE: To observe whether metformin (MET) inhibits transforming growth factor-β1 (TGF-β1 )/Smad3 signaling pathway by activating adenosine activated protein kinase (AMPK), so as to alleviate the pulmonary fibrosis caused by paraquat (PQ) poisoning in mice. METHODS: Male C57BL/6J mice were randomly divided into the Control group, PQ poisoning model group (PQ group), MET intervention group (PQ+MET group), AMPK agonist group (PQ+AICAR group), and AMPK inhibitor group (PQ+MET+CC group), according to a random number table method...
December 2023: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://read.qxmd.com/read/38145606/investigating-the-therapeutic-effects-and-mechanisms-of-roxadustat-on-peritoneal-fibrosis-based-on-the-tgf-%C3%AE-smad-pathway
#25
JOURNAL ARTICLE
Lingyun Wang, Jiangqing Fan, Ting Yang, Jizhong Shen, Lulu Wang, Weihong Ge
Peritoneal fibrosis (PF) is particularly common in individuals undergoing peritoneal dialysis (PD). Fibrosis of the parenchymal tissue typically progresses slowly. Therefore, preventing and reducing the advancement of fibrosis is crucial for effective patient treatment. Roxadustat is a hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI), primarily used to treat and improve renal anemia. Recent studies have found that HIF-1α possesses antioxidant activity and exerts a certain protective effect in ischemic heart disease and spinal cord injury, while it can also delay the progression of pulmonary and renal fibrosis...
December 14, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38144265/o-glcnacylation-regulates-hif-1%C3%AE-and-induces-mesothelial-mesenchymal-transition-and-fibrosis-of-human-peritoneal-mesothelial-cells
#26
JOURNAL ARTICLE
Jian Wang, Xin Lv, Ashanjiang Aniwan, Hongyan Liu, Yao Lin, Xian Shao, Saijun Zhou, Pei Yu
O-GlcNAcylation is a post-translational modification of proteins that regulates various biological processes. However, its involvement in peritoneal dialysis fibrosis remains unclear. This study aimed to investigate the impact of O-GlcNAcylation on human peritoneal mesothelial cells (HPMCs) cultured in control and high-glucose medium. To manipulate cellular conditions, we employed knockdown techniques targeting HIF-1α and OGT, along with the administration of pharmacological agents (PUGNAc, OSMI-1, MG-132, FG-4592, and HIF-1α inhibitor)...
December 2023: Heliyon
https://read.qxmd.com/read/38125084/retracted-sulodexide-prevents-peritoneal-fibrosis-by-downregulating-the-expression-of-tgf-%C3%AE-1-and-its-signaling-pathway-molecules
#27
Evidence-Based Complementary And Alternative Medicine
[This retracts the article DOI: 10.1155/2021/2052787.].
2023: Evidence-based Complementary and Alternative Medicine: ECAM
https://read.qxmd.com/read/38104523/2-deoxy-glucose-ameliorates-the-peritoneal-mesothelial-and-endothelial-barrier-function-perturbation-occurring-due-to-peritoneal-dialysis-fluids-exposure
#28
JOURNAL ARTICLE
Eleanna Pitaraki, Rajesh M Jagirdar, Erasmia Rouka, Maria Bartosova, Sotirios I Sinis, Konstantinos I Gourgoulianis, Theodoros Eleftheriadis, Ioannis Stefanidis, Vassilios Liakopoulos, Chrissi Hatzoglou, Claus Peter Schmitt, Sotirios G Zarogiannis
Peritoneal dialysis (PD) and prolonged exposure to PD fluids (PDF) induce peritoneal membrane (PM) fibrosis and hypervascularity, leading to functional PM degeneration. 2-deoxy-glucose (2-DG) has shown potential as PM antifibrotic by inhibiting hyper-glycolysis induced mesothelial-to-mesenchymal transition (MMT). We investigated whether administration of 2-DG with several PDF affects the permeability of mesothelial and endothelial barrier of the PM. The antifibrotic effect of 2-DG was confirmed by the gel contraction assay with embedded mesothelial (MeT-5A) or endothelial (EA...
December 13, 2023: Biochemical and Biophysical Research Communications
https://read.qxmd.com/read/38097887/a-protective-role-of-nintedanib-in-peritoneal-fibrosis-through-h19-ezh2-klf2-axis-via-impeding-mesothelial-to-mesenchymal-transition
#29
JOURNAL ARTICLE
Wei Zhong, Jia Fu, Jin Liao, Shaxi Ouyang, Wei Yin, Yumei Liang, Kanghan Liu
BACKGROUND: Peritoneal fibrosis (PF), a common complication of long-term peritoneal dialysis, accounts for peritoneal ultrafiltration failure to develop into increased mortality. Nintedanib has previously been shown to protect against multi-organ fibrosis, including PF. Unfortunately, the precise molecular mechanism underlying nintedanib in the pathogenesis of PF remains elusive. METHODS: The mouse model of PF was generated by chlorhexidine gluconate (CG) injection with or without nintedanib administration, either with the simulation for the cell model of PF by constructing high-glucose (HG)-treated human peritoneal mesothelial cells (HPMCs)...
December 14, 2023: International Urology and Nephrology
https://read.qxmd.com/read/38046778/rectus-urinoma-leading-to-abscess-following-urethral-perforation-from-self-catheterization-a-case-report
#30
Evan Scout James, Bailie Moorhead, Kimberly Lince, Young Son, Thomas J Mueller
Urinomas are an accumulation of urine in the perirenal or paraureteral space due to urinary tract leakage. Stimulation of an inflammatory response results in the formation of a thick wall that encapsulates the urine. Etiologies of urinomas include trauma, surgery, or spontaneous occurrence. Complications when untreated vary and include peritonitis, fibrosis, abscess formation, and septic shock. We present a 52-year-old male with a neurogenic bladder who developed a rectus urinoma from the thorax to the scrotum...
November 2023: Curēus
https://read.qxmd.com/read/38044124/continuous-infiltration-of-small-peritoneal-macrophages-in-the-mouse-peritoneum-through-ccr2-dependent-and-independent-routes-during-fibrosis-and-mesothelioma-development-induced-by-a-multiwalled-carbon-nanotube-mwnt-7
#31
JOURNAL ARTICLE
Motomu Shimizu, Motoki Hojo, Kiyomi Ikushima, Yukio Yamamoto, Ai Maeno, Yoshimitsu Sakamoto, Naozumi Ishimaru, Yuhji Taquahashi, Jun Kanno, Akihiko Hirose, Jin Suzuki, Akiko Inomata, Dai Nakae
Although toxicities of multiwalled carbon nanotube (MWCNT) have been found to be related with activities of macrophages phagocytosing the fibers, the exact relationship between macrophage population and pathogenesis of fibrosis and mesotheliomas induced by MWCNTs is largely unknown. CCL2-CCR2 axis, a major monocyte/macrophage infiltration route, is thought to be involved in not only acute inflammation but also the formation of tumor microenvironment. We therefore described a time-course of alteration of macrophage population in an attempt to clarify the contribution of the Ccr2 gene to mesotheliomagenesis...
2023: Journal of Toxicological Sciences
https://read.qxmd.com/read/38019178/recruitment-of-large-peritoneal-macrophages-to-capsular-fibrosis-developed-on-the-liver-surface
#32
JOURNAL ARTICLE
Steven Balog, Soi Jeong, Kinji Asahina
Upon injury to Glisson's capsule, mesothelial cells covering the liver surface differentiate into myofibroblasts and participate in capsular fibrosis. In the fibrotic area, infiltrating macrophages are present, but their origin and role in capsular fibrosis remain elusive. In the present study, we examined whether macrophages in the peritoneal cavity migrate to the liver and participate in capsular fibrosis. Capsular fibrosis was induced by intraperitoneal injection of chlorhexidine gluconate. Chlorhexidine gluconate treatment induced disappearance of CD11bHigh F4/80High large peritoneal macrophages from the peritoneal cavity...
January 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/38017611/preventive-effect-of-culture-supernatant-of-epithelial-like-peritoneal-mesothelial-cells-on-peritoneal-fibrosis
#33
JOURNAL ARTICLE
Kensaku Takahashi, Kenji Tsuji, Hiroyuki Nakanoh, Kazuhiko Fukushima, Shinji Kitamura, Jun Wada
Peritoneal fibrosis (PF) is a primary reason for discontinuing peritoneal dialysis, which involves characteristic changes of peritoneal mesothelial cells (PMCs). We previously reported preventive effects of implanting human epithelial-like PMCs (P-Epi) for mouse PF caused by mechanical peritoneum scrapings. In the present study, we analysed the preventive effects of culture supernatant of P-Epi in PF. Concentrated culture supernatant of P-Epi or human fibroblast-like PMCs (P-Fibro) or vehicles was injected into nude mice that had undergone mechanical scraping of the parietal and visceral peritoneum, and thickness and amount of adhesions were analysed...
November 28, 2023: Peritoneal Dialysis International
https://read.qxmd.com/read/38013428/plasma-d-dimer-levels-are-associated-with-disease-progression-in-diabetic-nephropathy-a-two-center-cohort-study
#34
JOURNAL ARTICLE
Yedong Yu, Caifeng Zhu, Yi Lin, Qian Qian, Xiaogang Shen, Wenli Zou, Minmin Wang, Jianguang Gong, Maosheng Chen, Lin Liu, Rizhen Yu, Quanquan Shen, Lina Shao, Bin Zhu
BACKGROUND: This study aimed to investigate the relationship between plasma D-dimer levels, clinicopathological features, and clinical outcomes in patients with biopsy-proven diabetic nephropathy (DN). METHODS: A total of 137 patients with biopsy-proven DN were enrolled in this two-center cohort study. Patients were stratified into tertiles based on plasma D-dimer levels. We investigated the relationship between plasma D-dimer levels and clinical outcomes, including a composite of death, a 40% decline in estimated glomerular filtration rate (e-GFR) from baseline, or end-stage renal disease (ESRD) (defined as e-GFR < 15 mL/min/1...
2023: Renal Failure
https://read.qxmd.com/read/38006449/3d-printing-injectable-microbeads-using-a-composite-liposomal-ink-for-local-treatment-of-peritoneal-diseases
#35
JOURNAL ARTICLE
Remo Eugster, Aymar Abel Ganguin, Amirmohammad Seidi, Simone Aleandri, Paola Luciani
The peritoneal cavity offers an attractive administration route for challenging-to-treat diseases, such as peritoneal carcinomatosis, post-surgical adhesions, and peritoneal fibrosis. Achieving a uniform and prolonged drug distribution throughout the entire peritoneal space, though, is difficult due to high clearance rates, among others. To address such an unmet clinical need, alternative drug delivery approaches providing sustained drug release, reduced clearance rates, and a patient-centric strategy are required...
November 25, 2023: Drug Delivery and Translational Research
https://read.qxmd.com/read/38003303/novel-peritoneal-sclerosis-rat-model-developed-by-administration-of-bleomycin-and-lansoprazole
#36
JOURNAL ARTICLE
Kosei Kunitatsu, Yuta Yamamoto, Shota Nasu, Akira Taniji, Shuji Kawashima, Naoko Yamagishi, Takao Ito, Shigeaki Inoue, Yoshimitsu Kanai
In our preliminary experiment, peritoneal sclerosis likely induced by peritoneal dialysis was unexpectedly observed in the livers of rats given bleomycin and lansoprazole. We examined whether this peritoneal thickening around the liver was time-dependently induced by administration of both drugs. Male Wistar rats were injected with bleomycin and/or lansoprazole for 2 or 4 weeks. The 3YB-1 cell line derived from rat fibroblasts was treated by bleomycin and/or lansoprazole for 24 h. The administration of both drugs together, but not individually, thickened the peritoneal tissue around the liver...
November 9, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37989866/tumor-mesothelium-hoxa11-pdgf-bb-tgf-%C3%AE-1-mir-181a-5p-egr1-feedforward-amplifier-circuity-propels-mesothelial-fibrosis-and-peritoneal-metastasis-of-gastric-cancer
#37
JOURNAL ARTICLE
Chao Wang, Jun Ji, Yangbing Jin, Ying Sun, Qu Cai, Jinling Jiang, Liting Guo, Chenfei Zhou, Jun Zhang
A proportion of gastric cancer (GC) patients suffer from peritoneal metastasis (PM) in the late stage of tumor and these patients have a poor prognosis. To provide more care for GC patient with PM, a deeper exploration of the molecular characteristics of GC-PM is needed. Here we performed the in vitro and in vivo study to illustrate the effect of HOXA11 over-expressed GC cells on peritoneal mesothelial cells (HMrSV5), transcriptomics analyses of HMrSV5 cells co-cultured with HOXA11 over-expressed GC cells, counterparts or alone, cytokine array analyses of serum-free culture medium of HOXA11 over-expressed GC cells, we validated our findings through genetic manipulation of HMrSV5 cells and neutralizing antibodies targeting cytokines secreted by HOXA11 over-expressed GC cells in vitro, as well as utilized human peritoneal metastatic lesions to validate expression of potential targets...
November 21, 2023: Oncogene
https://read.qxmd.com/read/37969180/postoperative-peritoneal-inflammatory-granuloma-mimicking-peritoneal-metastasis-in-a-patient-with-breast-cancer-a-case-report
#38
Young Jin Choi, Sungmin Park, Seung-Myoung Son, Hae-Won Seo, Jihye Hwang, Se Joon Jung, Young Duck Shin
Peritoneal metastasis from breast cancer is a relatively rare life-threatening condition. The gold standard for diagnosing peritoneal metastasis is a direct peritoneal biopsy. In this report, we describe an interesting case of peritoneal inflammation mimicking peritoneal metastasis in a patient with breast cancer, as confirmed by laparoscopic peritoneal biopsy. A 45-year-old woman with a history of right breast cancer presented with a peritoneal wall mass seen on an abdominal computed tomography (CT) in routine follow-up...
2023: American Journal of Translational Research
https://read.qxmd.com/read/37919475/isoproterenol-induces-md2-activation-by-%C3%AE-ar-camp-pka-ros-signalling-axis-in-cardiomyocytes-and-macrophages-drives-inflammatory-heart-failure
#39
JOURNAL ARTICLE
Jin-Fu Qian, Shi-Qi Liang, Qin-Yan Wang, Jia-Chen Xu, Wu Luo, Wei-Jian Huang, Gao-Jun Wu, Guang Liang
Cardiac inflammation contributes to heart failure (HF) induced by isoproterenol (ISO) through activating β-adrenergic receptors (β-AR). Recent evidence shows that myeloid differentiation factor 2 (MD2), a key protein in endotoxin-induced inflammation, mediates inflammatory heart diseases. In this study, we investigated the role of MD2 in ISO-β-AR-induced heart injuries and HF. Mice were infused with ISO (30 mg·kg-1 ·d-1 ) via osmotic mini-pumps for 2 weeks. We showed that MD2 in cardiomyocytes and cardiac macrophages was significantly increased and activated in the heart tissues of ISO-challenged mice...
November 2, 2023: Acta Pharmacologica Sinica
https://read.qxmd.com/read/37907805/severity-of-acute-portal-hypertension-determines-the-clinical-outcomes-in-severe-alcoholic-hepatitis
#40
JOURNAL ARTICLE
Ankur Jindal, Manoj K Sharma, Rajan Vijayaraghavan, Shasthry Sm, Guresh Kumar, Shiv K Sarin
BACKGROUND: Severe alcohol-associated hepatitis (SAH) presenting as acute-on-chronic liver failure (ACLF) has high mortality. Severe hepatic inflammation and ongoing hepatocellular cell death lead to rapid rise in portal pressure, a hyperdynamic circulation that might precipitate infections and organ failures. METHODS: Consecutive SAH patients were classified based on baseline HVPG measurement as 6to < 12 mmHg, 12to < 20 mmHg, and ≥ 20 mmHg...
October 31, 2023: Digestive Diseases and Sciences
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