keyword
MENU ▼
Read by QxMD icon Read
search

Peritoneal fibrosis

keyword
https://www.readbyqxmd.com/read/29450853/endometriosis-clinical-features-mr-imaging-findings-and-pathologic-correlation
#1
REVIEW
Pietro Valerio Foti, Renato Farina, Stefano Palmucci, Ilenia Anna Agata Vizzini, Norma Libertini, Maria Coronella, Saveria Spadola, Rosario Caltabiano, Marco Iraci, Antonio Basile, Pietro Milone, Antonio Cianci, Giovanni Carlo Ettorre
OBJECTIVE: We illustrate the magnetic resonance imaging (MRI) features of endometriosis. BACKGROUND: Endometriosis is a chronic gynaecological condition affecting women of reproductive age and may cause pelvic pain and infertility. It is characterized by the growth of functional ectopic endometrial glands and stroma outside the uterus and includes three different manifestations: ovarian endometriomas, peritoneal implants, deep pelvic endometriosis. The primary locations are in the pelvis; extrapelvic endometriosis may rarely occur...
February 15, 2018: Insights Into Imaging
https://www.readbyqxmd.com/read/29444417/a-study-on-the-regenerative-effect-of-platelets-rich-plasma-on-experimentally-induced-hepatic-damage-in-albino-rats
#2
Heba Mamdoh Shoeib, Walaa Arafa Keshk, Abdallah Mahmoud Foda, Saad El-Deen Abd Elfatah Abo El Noeman
Hepatic fibrosis is a worldwide health problem with significant morbidity and mortality. Currently, there is no effective therapy for hepatic fibrosis. So that the present study was aimed to evaluate the possible regenerative effect of Platelet-rich plasma (PRP) against thioacetamide (TAA) induced hepatic damage. Eighty albino rats were included; 40 were used for PRP preparation and 40 were randomly divided into four groups. Group I (control group); group II (PRP control); group III (TAA- intoxicated in a dose of 200 mg ∕ kg body weight/twice weekly for 7 weeks, intra-peritoneal and group IV (TAA-intoxicated+ PRP treated)...
February 14, 2018: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/29433874/acellular-derivatives-of-mesenchymal-stem-cells-prevent-peritoneal-adhesions-in-an-animal-model
#3
Daniel Rojo, Paulette Conget
BACKGROUND: Peritoneal adhesions are nonanatomical connections that bind organs to the abdominal wall or among them. They arise after peritoneal injury, which triggers an inflammatory response followed by a healing process that leads to fibrotic tissue formation. Mesenchymal stem cells and their secretion products, also referred to as acellular derivatives (ACDs), have anti-inflammatory, fibrinolytic, and antifibrogenic properties. The aim of this study was to determine the effect of intraoperative administration of ACD on the appearance, severity, and progression of peritoneal adhesions, in an animal model...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29422906/the-complement-system-in-dialysis-a-forgotten-story
#4
REVIEW
Felix Poppelaars, Bernardo Faria, Mariana Gaya da Costa, Casper F M Franssen, Willem J van Son, Stefan P Berger, Mohamed R Daha, Marc A Seelen
Significant advances have lead to a greater understanding of the role of the complement system within nephrology. The success of the first clinically approved complement inhibitor has created renewed appreciation of complement-targeting therapeutics. Several clinical trials are currently underway to evaluate the therapeutic potential of complement inhibition in renal diseases and kidney transplantation. Although, complement has been known to be activated during dialysis for over four decades, this area of research has been neglected in recent years...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29422602/acidic-organelles-mediate-tgf-%C3%AE-1-induced-cellular-fibrosis-via-pro-renin-receptor-and-vacuolar-atpase-trafficking-in-human-peritoneal-mesothelial-cells
#5
Ikuko Oba-Yabana, Takefumi Mori, Chika Takahashi, Takuo Hirose, Yusuke Ohsaki, Satoshi Kinugasa, Yoshikazu Muroya, Emiko Sato, Geneviève Nguyen, Rémi Piedagnel, Pierre M Ronco, Kazuhito Totsune, Sadayoshi Ito
TGF-β1, which can cause renal tubular injury through a vacuolar-type H+-ATPase (V-ATPase)-mediated pathway, is induced by the glucose degradation product methylglyoxal to yield peritoneal injury and fibrosis. The present study investigated the roles of V-ATPase and its accessory protein, the (pro)renin receptor, in peritoneal fibrosis during peritoneal dialysis. Rats daily administered 20 mM methylglyoxal intraperitoneally developed significant peritoneal fibrosis after 7 days with increased expression of TGF-β and V-ATPase, which was reduced by the inhibition of V-ATPase with co-administration of 100 mM bafilomycin A1...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29407850/in-vivo-treatment-with-il-17a-attenuates-hydatid-cyst-growth-and-liver-fibrogenesis-in-an-experimental-model-of-echinococcosis
#6
Moussa Labsi, Imene Soufli, Lila Khelifi, Zine-Charaf Amir, Chafia Touil-Boukoffa
We aimed to assess the effect of exogenous Interleukin (IL)-17A in experimental model of echinococcosis. Swiss mice were inoculated intra-peritoneally with viable protoscoleces (PSCs). Then, IL-17A was administered at 100, 125 or 150 pg/mL two weeks after cystic echinococcosis (CE) induction. Cyst development and hepatic damage were macroscopically and histologically analyzed. We observed that in vivo IL-17A treatment at 100, 125, and 150 pg/mL, reduced metacestode growth by 72.3%, 93.8%, and 96.9%, respectively...
January 29, 2018: Acta Tropica
https://www.readbyqxmd.com/read/29386308/effects-of-oral-paricalcitol-and-calcitriol-treatment-on-peritoneal-membrane-characteristics-of-peritoneal-dialysis-patients-a-pilot-study
#7
Karima Farhat, Andrea W Stavenuiter, Marc Vervloet, Pieter M Ter Wee, Robert H Beelen, Frans J van Ittersum
BACKGROUND: Long-term peritoneal dialysis (PD) is frequently complicated by technique failure preceded by peritoneal remodeling. Vitamin D has potent immunomodulatory characteristics: anti-inflammatory, anti-angiogenic, anti-fibrotic properties, and influences on the macrophage phenotype. Little is known about the relation between pleiotropic effects attributed to vitamin D3 and the peritoneal membrane and what is the most appropriate vitamin D sterol in prevention of peritoneal remodeling in PD patients...
January 31, 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29371507/burden-of-serious-fungal-infections-in-jordan
#8
Jamal Wadi, David W Denning
OBJECTIVE: To estimate the burden of fungal infections in Jordan for the first time. MATERIAL AND METHODS: Population data was from UN 2011 statistics and TB cases from WHO in 2012. Fewer than 100 patients with HIV were recorded in Jordan in 2013. Approximately 100 renal transplants and eight liver transplants are performed annually. There were 12,233 major surgical procedures in Jordan in 2013, of which 5.3% were major abdominal surgeries; candidemia was estimated in 5% of the population based on other countries, with 33% occurring in the ICU...
January 18, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29363326/wnt-signaling-is-required-for-peritoneal-membrane-angiogenesis
#9
Manreet Kaur Padwal, Genyang Cheng, Limin Liu, Felix J Boivin, Azim Gangji, Kenneth Scott Brimble, Darren Bridgewater, Peter J Margetts
The WNT signaling pathway is involved in wound healing and fibrosis. We evaluated the WNT signaling pathway in peritoneal membrane injury. We assessed WNT1 protein expression in the peritoneal effluents of 54 stable peritoneal dialysis (PD) patients and WNT-related gene expression in ex vivo mesothelial cell cultures from 21 PD patients. In a transforming growth factor beta (TGFB) mediated animal model of peritoneal fibrosis, we evaluated regulation of the WNT pathway and the effect of WNT inhibition on peritoneal fibrosis and angiogenesis...
January 24, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29357421/mir-200a-negatively-regulates-tgf-%C3%AE-1-induced-epithelial-mesenchymal-transition-of-peritoneal-mesothelial-cells-by-targeting-zeb1-2-expression
#10
Runsheng Guo, Guojun Hao, Yi Bao, Jun Xiao, Xiaojiang Zhan, Xintian Shi, Laimin Luo, Jing Zhou, Qinkai Chen, Xin Wei
Although epithelial-mesenchymal transition (EMT) of peritoneal mesothelial cells was recognized as the key process of peritoneal fibrosis, which is a major cause of peritoneal failure related to peritoneal dialysis (PD), mechanisms underlying these processes remain largely unknown. In this study, we found that miR-200a was significantly down-regulated in peritoneal tissues with fibrosis in a rat model of PD. In vitro, transforming growth factor (TGF)-β1-induced EMT, identified by de novo expression of α-SMA and a loss of E-cadherin in human peritoneal mesothelial cells (HPMCs), was associated with down-regulation of miR-200a but up-regulation of zinc finger E-box-binding homeobox 1/2 (ZEB1/2), suggesting a close link between miR-200a and ZEB1/2 in TGF-β1-induced EMT...
January 10, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29353856/-pneumatosis-cystoides-intestinalis-pci-with-sigmoid-volvulus-a-case-potentially-associated-with-lymphatic-vessels
#11
Haruyasu Honda, Seiichi Hayashi, Toshihisa Tsukadaira, Yasuhiro Sekiguchi
An 80-year-old woman was brought to our hospital in an ambulance because of signs of peritoneal irritation. Computed tomography revealed volvulus, sigmoid colon dilation, and free air and pneumatosis within the colonic and bowel wall. An emergency laparotomy was performed after the diagnosis of colonic perforation associated with volvulus or pneumatosis. Numerous gas-filled cysts, up to 10mm in diameter, were located in the resected bowel wall. The cells at the inner lining of the cysts tested positive for D2-40 immunoreactivity, seemingly originating from the lymphatic vessels...
2018: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/29343697/effluent-and-serum-protein-n-glycosylation-is-associated-with-inflammation-and-peritoneal-membrane-transport-characteristics-in-peritoneal-dialysis-patients
#12
Evelina Ferrantelli, Karima Farhat, Agnes L Hipgrave Ederveen, Karli R Reiding, Robert H J Beelen, Frans J van Ittersum, Manfred Wuhrer, Viktoria Dotz
Mass spectrometric glycomics was used as an innovative approach to identify biomarkers in serum and dialysate samples from peritoneal dialysis (PD) patients. PD is a life-saving treatment worldwide applied in more than 100,000 patients suffering from chronic kidney disease. PD treatment uses the peritoneum as a natural membrane to exchange waste products from blood to a glucose-based solution. Daily exposure of the peritoneal membrane to these solutions may cause complications such as peritonitis, fibrosis and inflammation which, in the long term, lead to the failure of the treatment...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29322409/tracking-competent-host-defence-to-chronic-inflammation-an-in-vivo-model-of-peritonitis
#13
Javier Uceda Fernandez, David Millrine, Simon A Jones
Anti-microbial host defence is dependent on the rapid recruitment of inflammatory cells to the site of infection, the elimination of invading pathogens, and the efficient resolution of inflammation so as to minimise damage to the host. The peritoneal cavity provides an easily accessible and physiologically relevant system where the delicate balance of these processes may be studied. Here, we describe murine models of peritoneal inflammation that enable studies of both competent anti-microbial immunity and inflammation associated tissue damage as a consequence of recurrent bacterial challenge...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29306153/a-pathogenetic-role-for-m1-macrophages-in-peritoneal-dialysis-associated-fibrosis
#14
Qing Li, Min Zheng, Yueheng Liu, Wei Sun, Jun Shi, Jie Ni, Qiong Wang
Peritoneal fibrosis (PF) is a frequent complication of peritoneal dialysis (PD) accompanied by the infiltration of inflammatory cells. Recently, the function of macrophages in an inflammatory microenvironment during PD remains unknown. This study aimed to elucidate the role of distinct macrophage phenotypes in the progression of PF through macrophage depletion in a peritoneal dialysis-induced mouse model. After injection of 200 μl liposomal clodronate (LC) at the start of instillation PD fluids (PDFs), mice were injected with 100 μL LC every 4 days after the first time injection for longer macrophage depletion, while control mice were co-treated with PBS liposomes...
January 3, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29290508/the-emergency-medicine-evaluation-and-management-of-the-patient-with-cirrhosis
#15
REVIEW
Brit Long, Alex Koyfman
BACKGROUND: Cirrhosis is a significant cause of death in the U.S. and has a variety of causes, most commonly Hepatitis C and alcohol. Liver fibrosis and nodule formation result in significant complications due to portal system hypertension. There are several deadly complications emergency physicians must consider. OBJECTIVE OF THE REVIEW: Provide an evidence-based update for the resuscitation of decompensating cirrhotic patients and an overview of cirrhosis complications...
December 23, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29208752/effects-of-alanyl-glutamine-treatment-on-the-peritoneal-dialysis-effluent-proteome-reveal-pathomechanism-associated-molecular-signatures
#16
Rebecca Herzog, Michael Boehm, Markus Unterwurzacher, Anja Wagner, Katja Parapatics, Peter Majek, André C Mueller, Anton Lichtenauer, Keiryn L Bennett, Seth L Alper, Andreas Vychytil, Christoph Aufricht, Klaus Kratochwill
Peritoneal dialysis (PD) is a modality of renal replacement therapy in which the high volumes of available PD effluent (PDE) represents a rich source of biomarkers for monitoring disease and therapy. Although this information could help guide the management of PD patients, little is known about the potential of PDE to define pathomechanism-associated molecular signatures in PD.</p> <p>We therefore subjected PDE to a high-performance multiplex proteomic analysis after depletion of highly-abundant plasma proteins and enrichment of low-abundance proteins...
December 4, 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/29207016/microrna-21-promotes-the-progression-of-peritoneal-fibrosis-through-the-activation-of-the-tgf-%C3%AE-smad-signaling-pathway-an-in-vitro-and-in-vivo-study
#17
Ya-Li Ma, Fang Chen, Su-Xia Yang, Bao-Ping Chen, Jun Shi
The present study aimed to explore the roles of microRNA-21 (miR‑21) and the transforming growth factor-β (TGF-β)/Smad signaling pathway in the development of peritoneal fibrosis (PF). First, dialysis effluents from 30 patients with PF were collected, and after the establishment of a mouse model of PF, hematoxylin and eosin (H&E) and Masson's staining were used to observe peritoneal tissues, inflammatory cells and blood vessels. High glucose was used to stimulate human peritoneal mesothelial cell lines and these stimulated cells were then transfected with miR‑21 inhibitor...
November 17, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29179471/histone-deacetylase-6-inhibition-counteracts-the-epithelial-mesenchymal-transition-of-peritoneal-mesothelial-cells-and-prevents-peritoneal-fibrosis
#18
Liuqing Xu, Na Liu, Hongwei Gu, Hongrui Wang, Yingfeng Shi, Xiaoyan Ma, Shuchen Ma, Jun Ni, Min Tao, Andong Qiu, Shougang Zhuang
The role of histone deacetylase 6 (HDAC6) in peritoneal fibrosis remains unknown. In this study, we examined the effect of HDAC6 inhibition on the epithelial-mesenchymal transition (EMT) of peritoneal mesothelial cells and development of peritoneal fibrosis. Treatment with tubastatin A, a highly selective HDAC6 inhibitor, or silencing of HDAC6 with siRNA inhibited transforming growth factor β1-induced EMT, as evidenced by decreased expression of α-smooth muscle actin, collagen I and preserved expression of E-cadherin in cultured human peritoneal mesothelial cells...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29165602/deletion-of-connective-tissue-growth-factor-ameliorates-peritoneal-fibrosis-by-inhibiting-angiogenesis-and-inflammation
#19
Naohiro Toda, Kiyoshi Mori, Masato Kasahara, Kenichi Koga, Akira Ishii, Keita P Mori, Keisuke Osaki, Masashi Mukoyama, Motoko Yanagita, Hideki Yokoi
Background: Connective tissue growth factor (CTGF/CCN2) regulates the signalling of other growth factors and promotes fibrosis. CTGF is increased in mice and humans with peritoneal fibrosis. Inhibition of CTGF has not been examined as a potential therapeutic target for peritoneal fibrosis because systemic CTGF knockout mice die at the perinatal stage. Methods: To study the role of CTGF in peritoneal fibrosis of adult mice, we generated CTGF conditional knockout (cKO) mice by crossing CTGF floxed mice with RosaCreERT2 mice...
November 17, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29163160/aberrant-wnt-beta-catenin-pathway-activation-in-dialysate-induced-peritoneal-fibrosis
#20
Yuanyuan Guo, Lin Sun, Li Xiao, Rong Gou, Yudong Fang, Yan Liang, Ruiqiang Wang, Ningjun Li, Fuyou Liu, Lin Tang
Peritoneal dialysis (PD)-associated peritoneal fibrosis is a chronic progress which induces ultrafiltration failure. It remains a challenge to prevent the progression of PD-associated fibrosis in clinic practice. Wnt/β-catenin pathway plays important role in many severe fibrotic diseases, here we investigated its contribution to the development of peritoneal damage. We isolated mesothelial cells (MC) from the effluent of PD patients and found that the expressions of Wnt1, Wnt5a, β-catenin, and LEF1 were increased in patients with more than 1-year PD compared with patients who just started with PD (<1 month)...
2017: Frontiers in Pharmacology
keyword
keyword
64951
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"