keyword
MENU ▼
Read by QxMD icon Read
search

Peritoneal fibrosis

keyword
https://www.readbyqxmd.com/read/29033853/proinflammatory-effect-of-high-glucose-concentrations-on-hmrsv5-cells-via-the-autocrine-effect-of-hmgb1
#1
Yuening Chu, Yi Wang, Zhihuang Zheng, Yuli Lin, Rui He, Jun Liu, Xuguang Yang
Background: Peritoneal fibrosis, in which inflammation and apoptosis play crucial pathogenic roles, is a severe complication associated with the treatment of kidney failure with peritoneal dialysis (PD) using a glucose-based dialysate. Mesothelial cells (MCs) take part in the inflammatory processes by producing various cytokines and chemokines, such as monocyte chemoattractant protein 1 (MCP-1) and interleukin 8 (IL-8). The apoptosis of MCs induced by high glucose levels also contributes to complications of PD...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28992851/initiation-of-peritoneal-dialysis-in-the-first-weeks-after-catheter-insertion-a-comparison-of-a-neutral-ph-low-gdp-pd-fluid-and-a-conventional-pd-fluid%C3%A2
#2
Karima Farhat, Frans J van Ittersum, Pieter M Ter Wee, Nanne J Paauw, Robbert H J Beelen, Caroline E Douma
BACKGROUND: Chronic exposure to peritoneal dialysis (PD) fluid is associated with development of functional and structural alterations of the peritoneal membrane. The exact time point at which these changes actually occur is not known. Whether changes to the peritoneum occur immediately after installation of PD fluids and whether there is a difference between neutral-pH, low glucose degradation product (low-GDP) PD fluids and conventional PD fluids is not known either. MATERIALS AND METHODS: We performed an observational study...
October 10, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28990064/gaseous-signalling-molecule-so2-via-hippo%C3%A2-mst-pathway-to-improve-myocardial-fibrosis-of-diabetic-rats
#3
Maojun Liu, Shengquan Liu, Wenting Tan, Fen Tang, Junrong Long, Zining Li, Biao Liang, Chun Chu, Jun Yang
Recent studies have indicated the existence of an endogenous sulfur dioxide (SO2)‑generating system in the cardiovascular system. The present study aimed to discuss the function and regulatory mechanism of gaseous signal molecule SO2 in inhibiting apoptosis and endoplasmic reticulum stress (ERS) via the Hippo‑MST signaling pathway to improve myocardial fibrosis of diabetic rats. A total of 40 male Sprague‑Dawley rats were randomly divided into four groups (10 rats per group): Normal control group (control group), diabetic rats group [streptozotocin (STZ) group], SO2 intervention group (STZ+SO2 group) and diabetes mellitus rats treated with L‑Aspartic acid β‑hydroxamate (HDX) group (HDX group)...
October 4, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28980533/rosuvastatin-administered-intraperitoneally-reduces-the-formation-of-postoperative-adhesions-in-rats
#4
Stefan Chiorescu, Nicolae Ovidiu Grad, Ion Aurel Mironiuc, Octavian Aurel Andercou
OBJECTIVES: The purpose of the present experimental research was to assess the efficacy of intraperitoneal administration of rosuvastatin in preventing the formation of postoperative peritoneal adhesions. MATERIAL AND METHOD: Peritoneal adhesions were induced in 120 male rats of the Wistar-Bratislava breed, divided into 4 groups (n=30), using a parietal and visceral abrasion model. Group I was designated as the control group; in the case of group II, a saline solution was administered intraperitoneally, while in the case of groups III and IV, rosuvastatin solution with a concentration of 10 mg/kg and 5 mg/kg, respectively, was administered in a single dose, during laparotomy...
September 26, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28978530/tgf-%C3%AE-1-vegf-a-pathway-induces-neoangiogenesis-with-peritoneal-fibrosis-in-patients-undergoing-peritoneal-dialysis
#5
Tetsuyoshi Kariya, Hayato Nishimura, Masashi Mizuno, Yasuhiro Suzuki, Yoshihisa Matsukawa, Fumiko Sakata, Shoichi Maruyama, Yoshifumi Takei, Yasuhiko Ito
The characteristic features of chronic peritoneal injury with peritoneal dialysis (PD) are submesothelial fibrosis and neoangiogenesis. Transforming growth factor (TGF)-β and vascular endothelial growth factor (VEGF)-A are the main mediators of fibrosis and neoangiogenesis, respectively; however, the effect of the interaction between them on the peritoneum is not well known. In this study, we investigated the relationship between TGF-β1 and VEGF-A in inducing peritoneal fibrosis using human tissues and dialysate, cultured cells, and animal models...
October 4, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28977410/endomyocardial-fibrosis-in-a-context-of-peritonitis
#6
Alexandre Leger, Alexia Hennig, Jerome Peyrou, Hubert Cochet
No abstract text is available yet for this article.
July 20, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28972947/the-peritoneum-health-disease-and-perspectives-regarding-tissue-engineering-and-cell-therapies
#7
Ronaldo J F C do Amaral, Kátia D Arcanjo, Márcia C El-Cheikh, Felipe L de Oliveira
There are several pathologies associated with the peritoneum, such as mesothelioma and peritonitis. Moreover, the peritoneum is widely used in ultrafiltration procedures, i.e., peritoneal dialysis, presenting advantages over hemodialysis. On the other hand, ultrafiltration failure may lead to dialysis-induced fibrosis and hypervolemia. Therefore, the pathophysiological study of this tissue is of extreme biomedical importance. Studies investigating the biology of the cells dwelling in the peritoneum wall provide evidence of their plasticity and progenitor features...
October 4, 2017: Cells, Tissues, Organs
https://www.readbyqxmd.com/read/28958769/the-value-of-18-f-fdg-pet-ct-in-the-distinction-between-retroperitoneal-fibrosis-and-its-malignant-mimics
#8
Yiwen Wang, Zhiwei Guan, Dai Gao, Gui Luo, Kunpeng Li, Yurong Zhao, Xiuru Wang, Jie Zhang, Jingyu Jin, Zheng Zhao, Chunhua Yang, Jianglin Zhang, Jian Zhu, Feng Huang
OBJECTIVE: To discuss the utility of (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computerized tomography (PET/CT) in the diagnosis of idiopathic retroperitoneal fibrosis (iRPF). METHODS: IRPF patients diagnosed between September 2011 and June 2016 were included. Retroperitoneal malignancy patients were included as control. The morphological features and FDG uptake of retroperitoneal lesions were measured along with lymph node (LN) mapping. RESULTS: Seventy-one iRPF patients were included...
August 3, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28943000/histological-and-immunohistochemical-study-of-cardiac-telocytes-in-a-rat-model-of-isoproterenol-induced-myocardial-infarction-with-a-reference-to-the-effect-of-grape-seed-extract
#9
Mai Salah Nour, Nahla Reda Sarhan, Shireen A Mazroa, Salwa A Gawish
INTRODUCTION: Cardiac telocytes (TCs) represent a unique type of cells that make a supportive network for stem cells that contribute in cardiac renewal, but their role during myocardial infarction (MI) is not clear. Grape seed extract (GSE) is a powerful natural antioxidant. AIM OF THE WORK: Quantitative study of cardiac TCs in a rat model of Isoproterenol (ISO)-induced MI, and to evaluate the effect of GSE on TCs and MI progression. MATERIALS AND METHODS: Seventy adult male albino rats were assigned into 4 groups; group I; control rats, group II received GSE (100mg/kg/day) dissolved in distilled water orally, group III received 2 intra-peritoneal injections of 85mg/kg ISO dissolved in saline on 14th and 15th day to induce MI, and group IV received GSE and ISO...
September 21, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28942023/mirna-23-regulates-high-glucose-induced-epithelial-to-mesenchymal-transition-in-human-mesotheial-peritoneal-cells-by-targeting-vdr
#10
Lina Yang, Yi Fan, Xiuli Zhang, Jianfei Ma
Epithelial-mesenchymal transition(EMT) is the main reason for peritoneal fibrosis and the mechanism underlying peritoneal EMT were extensively studied in recent years. Recent researches showed that miRNAs were so important in the development of organ EMT and fibrosis, the role of microRNAs on peritoneal dialysis have also been studied. In the current study, we investigated microRNA-23(miR-23) expression in high glucose(HG) induced EMT in human mesotheial peritoneal cells(HPMCs). We found that HG promoted EMT, which was characterized by the upregulation of mesenchymal markers α-SMA and FN and downregulation of epithelial marker E-cadherin...
September 20, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28938437/progressive-fibrosis-a-progesterone-and-klf11-mediated-sexually-dimorphic-female-response
#11
Chandra C Shenoy, Zaraq Khan, Ye Zheng, Tiffanny L Jones, Khashayarsha Khazaie, Gaurang S Daftary
Progressive scarring is ubiquitous postoperatively and in an array of chronic systemic diseases. Recent studies indicate that such scarring has a high female propensity; females are also almost exclusively affected by endometriosis, a common sex steroid-dependent fibrotic disease. Endometriosis-related fibrosis is regulated epigenetically through transcription factor Krüppel-like factor 11 (KLF11). In response to surgical induction of endometriosis, Klf11-/- female mice develop significant fibrosis in contrast to wild-type mice...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28926603/scavenging-of-reactive-oxygen-species-by-astaxanthin-inhibits-epithelial-mesenchymal-transition-in-high-glucose-stimulated-mesothelial-cells
#12
Kazuaki Hara, Chieko Hamada, Keiichi Wakabayashi, Reo Kanda, Kayo Kaneko, Satoshi Horikoshi, Yasuhiko Tomino, Yusuke Suzuki
BACKGROUND: High glucose concentrations influence the functional and structural development of the peritoneal membrane. We previously reported that the oral administration of astaxanthin (AST) suppressed peritoneal fibrosis (PF) as well as inhibited oxidative stress, inflammation, and epithelial-mesenchymal transition (EMT) of peritoneal mesothelial cells (PMCs) in a chlorhexidine-induced PF rat model. This suggests that oxidative stress induction of EMT is a key event during peritoneal damage...
2017: PloS One
https://www.readbyqxmd.com/read/28901812/efficacy-of-a-3c-like-protease-inhibitor-in-treating-various-forms-of-acquired-feline-infectious-peritonitis
#13
Niels C Pedersen, Yunjeong Kim, Hongwei Liu, Anushka C Galasiti Kankanamalage, Chrissy Eckstrand, William C Groutas, Michael Bannasch, Juliana M Meadows, Kyeong-Ok Chang
Objectives The safety and efficacy of the 3C-like protease inhibitor GC376 was tested on a cohort of client-owned cats with various forms of feline infectious peritonitis (FIP). Methods Twenty cats from 3.3-82 months of age (mean 10.4 months) with various forms of FIP were accepted into a field trial. Fourteen cats presented with wet or dry-to-wet FIP and six cats presented with dry FIP. GC376 was administered subcutaneously every 12 h at a dose of 15 mg/kg. Cats with neurologic signs were excluded from the study...
September 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28901396/effect-of-1-25-oh-2d3-on-high-glucose%C3%A2-induced-autophagy-inhibition-in-peritoneum
#14
Lina Yang, Yi Fan, Xiuli Zhang, Jin Liu, Jianfei Ma
High glucose (HG) may damage the structure and function of the peritoneal membrane, and is considered to be one of the most important factors that leads to peritoneal fibrosis and ultrafiltration failure. Recently, 1,25(OH)2D3, the active form of vitamin D, was demonstrated to protect against epithelial‑mesenchymal transition and fibrosis in peritoneal mesothelium and other organs. Accumulating evidence has suggested that autophagy serves a protective role in certain diseases by regulating cell survival...
November 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28886980/-dose-constraints-to-organs-at-risk-for-conformational-and-stereotactic-radiotherapy-small-bowel-and-duodenum
#15
REVIEW
F Goupy, E Chajon, J Castelli, É Le Prisé, L Duvergé, N Jaksic, G Vogin, É Monpetit, V Klein, L de Bosschère, P Maingon
Radiotherapy of abdominopelvic primary or secondary lesions in conformational or stereotactic techniques is in full development. The small bowel is highly sensitive to irradiation and is the main organ at risk limiting prescription doses. This literature review aims to define the dose constraints to the small bowel and the duodenum in conformational and stereotactic body radiotherapy. The small bowel including the duodenum, jejunum and ileum is delineated on the simulation scanner. The radio-induced intestinal toxicities are acute related to the cellular depopulation of the intestinal mucosa, and late of more complex pathophysiology associating depletion in stem cells, microangiopathy, chronic inflammation and fibrosis...
October 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28875950/blocking-posttranslational-core-fucosylation-ameliorates-rat-peritoneal-mesothelial-cell-epithelial-mesenchymal-transition
#16
Long-Kai Li, Nan Wang, Wei-Dong Wang, Xiang-Ning Du, Xin-Yu Wen, Ling-Yu Wang, Yi-Yao Deng, Da-Peng Wang, Hong-Li Lin
Background: Core fucosylation (CF), catalyzed by α-1,6 fucosyltransferase (Fut8) in mammals, plays an important role in pathological processes through posttranslational modification of key signaling receptor proteins, including transforming growth factor (TGF)-β receptors and platelet-derived growth factor (PDGF) receptors. However, its effect on peritoneal fibrosis is unknown. Here, we investigated its influence on epithelial-mesenchymal transition (EMT) of rat peritoneal mesothelial cells (PMCs) in vitro induced by a high-glucose (HG) culture solution...
September 20, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28873458/anti-fibrotic-effects-of-valproic-acid-in-experimental-peritoneal-fibrosis
#17
Elerson C Costalonga, Luiza J de Freitas, Deise da S P Aragone, Filipe M O Silva, Irene L Noronha
BACKGROUND: Progressive fibrous thickening of the peritoneal membrane is a complication of long-term peritoneal dialysis (PD). TGF-β/Smad pathway activation, inflammation, and neoangiogenesis play important roles in peritoneal membrane (PM) changes induced by PD. Recently, histone deacetilase inhibitors (HDACi) have shown anti-fibrotic and anti-inflammatory effects in different experimental models. These drugs prevent deacetylation of histones causing a loosen chromatin, which in turn induce the expression of some anti-fibrotic genes...
2017: PloS One
https://www.readbyqxmd.com/read/28855611/co-encapsulation-and-co-transplantation-of-mesenchymal-stem-cells-reduces-pericapsular-fibrosis-and-improves-encapsulated-islet-survival-and-function-when-allografted
#18
Vijayaganapathy Vaithilingam, Margaret D M Evans, Denise M Lewy, Penelope A Bean, Sumeet Bal, Bernard E Tuch
Pericapsular fibrotic overgrowth (PFO) is associated with poor survival of encapsulated islets. A strategy to combat PFO is the use of mesenchymal stem cells (MSC). MSC have anti-inflammatory properties and their potential can be enhanced by stimulation with proinflammatory cytokines. This study investigated whether co-encapsulation or co-transplantation of MSC with encapsulated islets would reduce PFO and improve graft survival. Stimulating MSC with a cytokine cocktail of IFN-γ and TNF-α enhanced their immunosuppressive potential by increasing nitric oxide production and secreting higher levels of immunomodulatory cytokines...
August 30, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28806968/cardamom-powder-supplementation-prevents-obesity-improves-glucose-intolerance-inflammation-and-oxidative-stress-in-liver-of-high-carbohydrate-high-fat-diet-induced-obese-rats
#19
Md Mizanur Rahman, Mohammad Nazmul Alam, Anayt Ulla, Farzana Akther Sumi, Nusrat Subhan, Trisha Khan, Bishwajit Sikder, Hemayet Hossain, Hasan Mahmud Reza, Md Ashraful Alam
BACKGROUND: Cardamom is a well-known spice in Indian subcontinent, used in culinary and traditional medicine practices since ancient times. The current investigation was untaken to evaluate the potential benefit of cardamom powder supplementation in high carbohydrate high fat (HCHF) diet induced obese rats. METHOD: Male Wistar rats (28 rats) were divided into four different groups such as Control, Control + cardamom, HCHF, HCHF + cardamom. High carbohydrate and high fat (HCHF) diet was prepared in our laboratory...
August 14, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28800626/targeting-lysyl-oxidase-reduces-peritoneal-fibrosis
#20
Christopher R Harlow, Xuan Wu, Marielle van Deemter, Fiona Gardiner, Craig Poland, Rebecca Green, Sana Sarvi, Pamela Brown, Karl E Kadler, Yinhui Lu, J Ian Mason, Hilary O D Critchley, Stephen G Hillier
BACKGROUND: Abdominal surgery and disease cause persistent abdominal adhesions, pelvic pain, infertility and occasionally, bowel obstruction. Current treatments are ineffective and the aetiology is unclear, although excessive collagen deposition is a consistent feature. Lysyl oxidase (Lox) is a key enzyme required for crosslinking and deposition of insoluble collagen, so we investigated whether targeting Lox might be an approach to reduce abdominal adhesions. METHODS: Female C57Bl/6 mice were treated intraperitoneally with multiwalled carbon nanotubes (NT) to induce fibrosis, together with chemical (ß-aminoproprionitrile-BAPN) or miRNA Lox inhibitors, progesterone or dexamethasone...
2017: PloS One
keyword
keyword
64951
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"