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https://www.readbyqxmd.com/read/29471605/-emerging-therapies-what-are-promising-in-the-near-future
#1
REVIEW
Geom Seog Seo, Sung Hee Lee
The treatment of inflammatory bowel disease has evolved with the development of anti-TNF agents. In spite of long-term effectiveness, many patients do not respond or no longer responds to these drugs. Therefore, the development of new drugs that act on different inflammatory pathways has become necessary. Vedolizumab, a gut-specific biological agent, inhibits interaction α4β7 integrin with mucosal addressin cell adhesion molecule-1 without inhibiting systemic immune responses. Long-term vedolizumab therapy in patients with Crohn's disease and ulcerative colitis was safe and effective...
February 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29471602/-evolving-therapeutic-strategies-in-the-inflammatory-bowel-disease
#2
REVIEW
Soo Young Na, Won Moon
It is important to have effective therapeutic strategies and goals in clinical practice and research of inflammatory bowel disease. Conventional end points for clinical trials in Crohn's disease and ulcerative colitis have been based on composite indices, such as the Crohn's Disease Activity Index and the Mayo Clinic Score. Although these indices have been shown to reduce the intestinal injury to some extent, satisfactory results have not been obtained in improving the quality of life of patients. Recently, alternative measures of outcome and definitions of response are being developed beyond symptoms...
February 25, 2018: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/29471593/clinical-evolution-of-patients-with-new-onset-inflammatory-back-pain-a-population-based-cohort-study
#3
Runsheng Wang, Cynthia S Crowson, Kerry Wright, Michael M Ward
OBJECTIVE: Inflammatory back pain (IBP) is often an early manifestation of spondyloarthritis (SpA), but the prognosis of patients with incident IBP is unknown. We investigated the long-term outcomes of patients with IBP, and predictors of progression to SpA, in a retrospective longitudinal study of a population-based cohort. METHODS: We used the Rochester Epidemiology Project, a longstanding population-based study of residents of Olmsted County, Minnesota, USA, to identify patients aged 16 to 35 with clinical visits for back pain from 1999 to 2003...
February 22, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29471590/consumer-use-and-response-to-online-third-party-raw-dna-interpretation-services
#4
Catharine Wang, Tiernan J Cahill, Andrew Parlato, Blake Wertz, Qiankun Zhong, Tricia Norkunas Cunningham, James J Cummings
BACKGROUND: With the availability of raw DNA generated from direct-to-consumer (DTC) testing companies, there has been a proliferation of third-party online services that are available to interpret the raw data for both genealogy and/or health purposes. This study examines the current landscape and downstream clinical implications of consumer use of third-party services. METHODS: Study participants were recruited online from social media platforms. A total of 321 survey respondents reported using third-party services for raw DNA interpretation...
January 2018: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/29471581/association-of-quantitative-and-topographic-assessment-of-heberden-s-nodes-with-knee-osteoarthritis-data-from-osteoarthritis-initiative
#5
Neil Kumar, Nima Hafezi-Nejad, Ali Guermazi, Arya Haj-Mirzaian, Ida K Haugen, Frank W Roemer, Shadpour Demehri
OBJECTIVE: To determine whether the presence, number, and topography (digit location and symmetry) of Heberden's nodes (HNs) are associated with radiographic knee osteoarthritis (OA) incidence and progression. METHODS: 8023 knees from the Osteoarthritis Initiative (OAI) were analyzed (8-years follow-up). Cox regression was performed on HN presence, total number, location, and symmetry (using two symmetry index models) obtained at baseline physical-examination as well as self-report of HN presence for evaluation of association with radiographic knee OA incidence (development of Kellgren-Lawrence grade≥2) and progression (worsening medial joint space narrowing score≥1)...
February 22, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29471572/-cardiovascular-medication-in-elderly-patients
#6
Robert H G Schwinger
Elderly people show increased probability to develop atherosclerotic diseases; in consequence heart failure - most often following coronary heart disease - as well as atrial fibrillation is more common. Following guidelines may lead to polypharmacy, i. e. use of more than 5 drugs daily. Thus, drug interactions as well as side effects become more likely; especially in elderly patients reduced kidney function has to be taken into account. Only drugs which have shown to prolong life or to reduce symptoms in controlled clinical trials should be used...
February 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29471569/does-transjugular-intrahepatic-portosystemic-shunt-stent-differentially-improve-survival-in-a-subset-of-cirrhotic-patients
#7
Jonel Trebicka
Does transjugular intrahepatic portosystemic shunt stent (TIPS) improve survival in a subgroup of patients? Yes. TIPS nearly halves portal pressure and increases the effective blood volume. In cases of acute variceal hemorrhage and with a high risk of treatment failure, defined as either hepatic venous pressure gradient higher than 20 mm Hg, Child B with active bleeding at the endoscopy, or Child C with less than 14 points, early or preemptive placement of TIPS (within 72 hours) improves survival. Also, in suitable patients with intractable or refractory ascites, TIPS improves survival if placed early in the course of treatment...
February 2018: Seminars in Liver Disease
https://www.readbyqxmd.com/read/29471564/genetic-and-epigenetic-heterogeneity-in-normal-liver-homeostasis-and-its-implications-for-liver-disease-and-hepatocellular-cancer
#8
Ryan A Hlady, Keith D Robertson
Hepatocellular carcinoma (HCC) is the most prevalent primary tumor of the liver, and is steadily becoming one of the most lethal cancers worldwide. Liver resection, which is the recommended procedure for early localized HCC, results in frequent recurrence (50-70%), while the standard of care for late-stage HCC, multikinase inhibitors, only improves survival by a few months. The lack of success for these treatment modalities is attributable, at least in part, to marked phenotypic heterogeneity within the tumor...
February 2018: Seminars in Liver Disease
https://www.readbyqxmd.com/read/29471560/knochensarkome
#9
Jendrik Hardes, Georg Gosheger, Timo Budny
Bone sarcomas are extremely rare representing approximately 0.2% among all cancer types. Due to the rarity of these tumors both the patients and the physicians can overlook or misinterpret the first often unspecific symptoms of these tumors (pain, limping and swelling). Therefore, radiographic examination (X-ray and/or MRI) of the involved region in case of inexplicable symptoms is strongly recommended. The most common primary malignant bone tumor entity is osteosarcoma, followed by chondrosarcoma and Ewing sarcoma...
February 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29471558/indication-technique-and-long-term-results-after-shoulder-arthrodesis-performed-with-plate-fixation
#10
Ulrich Irlenbusch, Olaf Rott, Lars Irlenbusch
AIM: Arthrodesis of the shoulder joint is a radical event, so it is difficult to explain its significance to patients. It has been the last resort in hopeless cases. Knowledge of long-term results and evaluation of advantages and disadvantages seems to be helpful in this regard. METHODS: Eleven patients with mean age of 45 (31 - 58) years were operated between 2000 and 2013. All patients could be included in the investigation (FU mean 8.5 [3 - 16] years; 8 male and 3 female; right 9, left 2)...
February 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/29471555/-pregnancy-after-obesity-and-metabolic-surgery-risks-and-complications
#11
Christine Stroh, Tanja Groten, Eckehardt Schleussner, Thomas Manger
The increasing prevalence of morbid obesity in Germany is associated with an increasing number of metabolic surgical interventions. Short-term surgical and long-term metabolic complications - such as nutrient deficiencies - are the main risks of metabolic surgery and the resulting malabsorption. Obesity, especially morbid obesity, is associated with a high incidence of female infertility. One important cause of female infertility in obese women is the polycystic ovary syndrome, with 6 - 10%. Metabolic surgery significantly increases the fertility of obese women...
February 22, 2018: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/29471553/-the-role-of-organizational-indicators-within-the-implementation-of-cross-sectoral-mental-health-care-and-home-treatment-in-germany-a-literature-and-theory-review
#12
Christian Klode, Tilman Steinert, Andreas Blume, Peter Brückner-Bozetti, Aysin Senkal, Michael Lingenfelder
OBJECTIVE: To elucidate organizational and human resource management-related drivers of community mental health services and home treatment in Germany. METHODS: Systematic review of psychiatric and organizational science literature, additional manual search. RESULTS: Relevant driver variables in community mental health services and home treatment have mostly been addressed. However, only a few have been evaluated and complex cause-and-effect models are missing so far...
February 22, 2018: Psychiatrische Praxis
https://www.readbyqxmd.com/read/29471548/maternal-smoking-during-pregnancy-and-negative-health-outcomes-in-the-offspring
#13
Ivan Berlin, Cheryl Oncken
No abstract text is available yet for this article.
February 17, 2018: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/29471544/10-best-resources-on-power-in-health-policy-and-systems-in-low-and-middle-income-countries
#14
Veena Sriram, Stephanie M Topp, Marta Schaaf, Arima Mishra, Walter Flores, Subramania Raju Rajasulochana, Kerry Scott
Power is a critical concept to understand and transform health policy and systems. Power manifests implicitly or explicitly at multiple levels-local, national and global-and is present at each actor interface, therefore shaping all actions, processes and outcomes. Analysing and engaging with power has important potential for improving our understanding of the underlying causes of inequity, and our ability to promote transparency, accountability and fairness. However, the study and analysis of the role of power in health policy and systems, particularly in the context of low- and middle-income countries, has been lacking...
February 17, 2018: Health Policy and Planning
https://www.readbyqxmd.com/read/29471539/breaking-down-barriers-to-the-utilization-of-standardized-tests-and-outcome-measures-in-acute-care-physical-therapist-practice-an-observational-longitudinal-study
#15
Brian McDonnell, Shannon Stilwell, Shelby Hart, Roger B Davis
Background: Standardized tests and outcome measures (STOM) have not been consistently implemented as part of most physical therapists' practice. Incidence of STOM use amongst physical therapists at Beth Israel Deaconess Medical Center was similar to low levels cited nationally among acute care physical therapists. Targeted knowledge translation (KT) strategies have been suggested to promote the application of research evidence into clinical decision making. Purpose: The purpose of this quality improvement (QI) effort was to implement a series of interventions aimed at increasing both use and interpretation of STOM by physical therapists practicing in acute care...
February 19, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29471526/predictors-and-outcomes-of-mealtime-emotional-climate-in-families-with-preschoolers
#16
Jaclyn A Saltzman, Kelly K Bost, Salma M A Musaad, Barbara H Fiese, Angela R Wiley
Objective: Mealtime emotional climate (MEC) is related to parent feeding and mental health, and possibly to child food consumption. However, MEC has been inconsistently assessed with a variety of coding schemes and self-report instruments, and has not been examined longitudinally. This study aims to characterize MEC systematically using an observational, count-based coding scheme; identify whether parent feeding or mental health predict MEC; and examine whether MEC predicts child food consumption and weight...
March 1, 2018: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29471520/effect-of-exposure-to-second-hand-smoke-from-husbands-on-biochemical-hyperandrogenism-metabolic-syndrome-and-conception-rates-in-women-with-polycystic-ovary-syndrome-undergoing-ovulation-induction
#17
Jian Li, Q Wu, Xiao-Ke Wu, Zhong-Ming Zhou, Ping Fu, Xiu-Hua Chen, Ying Yan, Xin Wang, Zheng-Wang Yang, Wei-Li Li, Elisabet Stener-Victorin, Richard S Legro, Ernest Hung-Yu Ng, Heping Zhang, Ben Willem J Mol, Chi Chiu Wang
STUDY QUESTION: Does second-hand smoke (SHS) exposure from husbands have adverse effects on sex hormones, metabolic profiles, clinical phenotypes and fertility outcomes in women with polycystic ovary syndrome (PCOS) undergoing ovulation induction? SUMMARY ANSWER: SHS exposure is associated with worsened biochemical hyperandrogenism, higher incidence of metabolic syndrome and reduced conception rates in women with PCOS. WHAT IS KNOWN ALREADY: Smoking in women impairs fecundity at some stages of the reproductive process including folliculogenesis, embryo transport, endometrial angiogenesis and uterine blood flow...
February 20, 2018: Human Reproduction
https://www.readbyqxmd.com/read/29471517/the-role-of-the-ground-glass-opacity-ratio-in-resected-lung-adenocarcinoma
#18
Tsai-Wang Huang, Kuan-Hsun Lin, Hsu-Kai Huang, Yi-I Chen, Kai-Hsiung Ko, Cheng-Kuang Chang, Hsian-He Hsu, Hung Chang, Shih-Chun Lee
OBJECTIVES: The goal of this study was to investigate the role of the ground-glass opacity (GGO) ratio in lung adenocarcinoma in predicting surgical outcomes. METHODS: Patients who underwent surgical resection for pulmonary adenocarcinoma between January 2004 and December 2013 were reviewed. The clinical data, imaging characteristics of nodules, surgical approaches and outcomes were analysed with a mean follow-up of 87 months. RESULTS: Of 789 enrolled patients, 267 cases were categorized as having a GGO ratio ≥0...
February 19, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29471511/sexual-dimorphism-in-the-behavioral-responses-and-the-immunoendocrine-status-in-d-galactose-induced-aging
#19
Raquel Baeta-Corral, Rafael Castro-Fuentes, Lydia Giménez-Llort
For almost twenty years, chronic systemic D-galactose, a monosaccharide abundantly present in milk products, fruits and vegetables, has been used as a tool to achieve models of accelerated aging. Its neurotoxicity, induced by abnormal accumulation of ROS and AGEs, has been widely reported. However, behavioral outcomes are still controversial and little is known about sex-dependent vulnerability. We performed a comprehensive behavioral and multi-functional screening of the chronic effects of low (50 mg/kg) and high (100 mg/kg) doses of D-galactose in 6-month-old male and female gold-standard C57BL/6 mice...
February 19, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29471510/moderator-s-view-low-protein-diet-in-chronic-kidney-disease-effectiveness-efficacy-and-precision-nutritional-treatments-in-nephrology
#20
Carmine Zoccali, Francesca Mallamaci
Intention-to-treat and per-protocol analyses provide complementary information about the usefulness of therapies. While intention-to-treat analyses of trials that tested low-protein diets remain debated, per-protocol analyses of the same trials show that low protein intake actually reduces the risk of kidney failure. Per-protocol analyses are notoriously open to bias but intention-to-treat analyses are less immaculate than commonly realized because they critically depend on adherence to the treatment being tested and therefore may not be directly relevant for informing clinical decisions when different degrees of adherence to therapy occur...
February 19, 2018: Nephrology, Dialysis, Transplantation
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