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Pathological gambling

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https://www.readbyqxmd.com/read/28728675/increased-striatal-dopamine-synthesis-capacity-in-gambling-addiction
#1
Ruth J van Holst, Guillaume Sescousse, Lieneke K Janssen, Marcel Janssen, Anne S Berry, William J Jagust, Roshan Cools
BACKGROUND: The hypothesis that dopamine plays an important role in the pathophysiology of pathological gambling is pervasive. However, there is little to no direct evidence for a categorical difference between pathological gamblers and healthy control subjects in terms of dopamine transmission in a drug-free state. Here we provide evidence for this hypothesis by comparing dopamine synthesis capacity in the dorsal and ventral parts of the striatum in 13 pathological gamblers and 15 healthy control subjects...
June 16, 2017: Biological Psychiatry
https://www.readbyqxmd.com/read/28720904/interaction-between-trait-and-housing-condition-produces-differential-decision-making-toward-risk-choice-in-a-rat-gambling-task
#2
Wha Young Kim, Bo Ram Cho, Myung Ji Kwak, Jeong-Hoon Kim
Poor decision-making is a core problem in psychiatric disorders such as pathological gambling and substance abuse. Both trait and environmental factors are considerably important to affect decision-making. However, it has not yet been systematically shown how they interact to affect risk preference in animal models evaluating decision-making. Here, we trained rats, housed in pairs or in isolation, in a touch screen chamber to detect the association between four different light signals on the screen and accompanied reward and punishment outcomes arranged with different schedules...
July 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28715699/gambling-and-negative-life-events-in-a-nationally-representative-sample-of-uk-men
#3
Amanda Roberts, Stephen Sharman, Jeremy Coid, Raegan Murphy, Henrietta Bowden-Jones, Sean Cowlishaw, Jason Landon
INTRODUCTION: The links between gambling problems, trauma and life stressors are known to exist but understanding the extent of these relationships will allow for greater efficacy in early intervention and treatment. We investigated these relationships among men and sought to determine whether links were attenuated by alcohol and drug use problems. METHODS: A cross-sectional UK representative general population survey was conducted in 2009 with 3025 men aged 18-64years...
July 9, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28696131/partial-dopamine-agonist-induced-pathological-gambling-and-impulse-control-deficit-on-low-dose-aripiprazole
#4
Evan Peterson, Rosaria Forlano
OBJECTIVE: To describe a case of aripiprazole-induced problem gambling and impulse-control deficit in a gambling-naïve patient following commencement of low-dose aripiprazole. METHOD: Case report. RESULTS: This case adds to the literature on the dopamine partial agonist aripiprazole causing or exacerbating problem gambling, and extends that literature to low-dose use of aripiprazole in the gambling naïve. CONCLUSIONS: When commencing a patient on aripiprazole the possibility of emergence of problem gambling and other impulse-control deficits should be monitored, even in those with no history of similar behaviours and even on a low dose...
July 1, 2017: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
https://www.readbyqxmd.com/read/28686562/-impulsivity-as-an-immediate-factor-between-addictive-disorders-and-attention-deficit-hyperactivity-disorder
#5
H Lazaratou, A Palaiologou, D Anagnostopoulos
Impulsivity is a behavior in everyday life of mentally healthy individuals. But in some cases the degree of impulsivity begins to create negative effects on one's life and acquires pathological connotation. Two clinical entities in which can be observed a high degree of impulsivity is Attention Deficit Hyperactivity Disorder (ADHD) and Addictive disorders. In these disorders, both impulsive act and impulsive choice are observed. According to some researchers, genetic factors are involved in the control of impulsivity...
April 2017: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/28685275/risk-factors-for-problem-gambling-in-california-demographics-comorbidities-and-gambling-participation
#6
Rachel A Volberg, Lauren M McNamara, Kari L Carris
While population surveys have been carried out in numerous jurisdictions internationally, little has been done to assess the relative strength of different risk factors that may contribute to the development of problem gambling. This is an important preparatory step for future research on the etiology of problem gambling. Using data from the 2006 California Problem Gambling Prevalence Survey, a telephone survey of adult California residents that used the NODS to assess respondents for gambling problems, binary logistic regression analysis was used to identify demographic characteristics, health-related behaviors, and gambling participation variables that statistically predicted the odds of being a problem or pathological gambler...
July 6, 2017: Journal of Gambling Studies
https://www.readbyqxmd.com/read/28678449/-is-video-game-addiction-a-reality
#7
Gabriel Thorens, Sophia Achab, Stephane Rothen, Yasser Khazaal, Daniele Zullino
Video games are widely practiced. Questions about their potential health risks arise, including the risk of addiction. If there is at present no official diagnosis of video games addiction, the DSM-5 proposes temporary criteria based on pathological gambling. Video game addiction affects a minority of at risk individuals. The proposed treatments are essentially psychotherapeutic. Video games practices can be non problematic and they may also have potential beneficial effects on individuals. It is therefore recommended, when assessing video games practices, to take into account the positive and negative impacts of their use...
September 21, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28668980/one-year-prospective-study-on-passion-and-gambling-problems-in-poker-players
#8
Adèle Morvannou, Magali Dufour, Natacha Brunelle, Djamal Berbiche, Élise Roy
The concept of passion is relevant to understanding gambling behaviours and gambling problems. Longitudinal studies are useful to better understand the absence and development of gambling problems; however, only one study has specifically considered poker players. Using a longitudinal design, this study aims to determine the influence, 1 year later, of two forms of passion-harmonious and obsessive-on gambling problems in poker players. A total of 116 poker players was recruited from across Quebec, Canada. The outcome variable of interest was participants' category on the Canadian Pathological Gambling Index, and the predictive variable was the Gambling Passion Scale...
July 1, 2017: Journal of Gambling Studies
https://www.readbyqxmd.com/read/28667828/the-relationship-between-gambling-expenditure-socio-demographics-health-related-correlates-and-gambling-behaviour-a-cross-sectional-population-based-survey-in-finland
#9
Sari Castrén, Jukka Kontto, Hannu Alho, Anne H Salonen
AIMS: To investigate gambling expenditure and its relationship with socio-demographics, health-related correlates and past-year gambling behaviour. DESIGN: Cross-sectional population survey. SETTING: Population-based survey in Finland. PARTICIPANTS: Finnish people aged 15-74 years randomly drawn from the Population Information System. The participants in this study were past-year gamblers (n = 3671; 1418 women and 1833 men)...
July 1, 2017: Addiction
https://www.readbyqxmd.com/read/28655790/targeting-vascular-endothelial-cadherin-in-tumor-associated-blood-vessels%C3%A2-promotes-t-cell-mediated-immunotherapy
#10
Yang Zhao, Kaka Ting, Jia Li, Victoria C Cogger, Jinbiao Chen, Anna Johansson-Percival, Shin Foong Ngiow, Jeff Holst, Georges E R Grau, Shom Goel, Thorleif Moller, Elisabetta Dejana, Geoffrey W McCaughan, Mark J Smyth, Ruth Ganss, Mathew A Vadas, Jennifer R Gamble
T cell infiltration of solid tumors is associated with improved prognosis and favorable responses to immunotherapy. Mechanisms that enable tumor infiltration of CD8(+) T cells have not been defined, nor have drugs that assist this process been discovered. Here we address these issues with a focus on VE-cadherin, a major endothelial cell-specific junctional protein that controls vascular integrity. A decrease in VE-cadherin expression is associated with tumor pathology. We developed an oligonucleotide-based inhibitor (CD5-2) which disrupted the interaction of VE-cadherin with its regulator miR-27a resulting in increased VE-cadherin expression...
June 27, 2017: Cancer Research
https://www.readbyqxmd.com/read/28645075/a-prospective-follow-up-study-of-younger-and-older-subjects-with-pathological-gambling
#11
Donald W Black, William Coryell, Brett McCormick, Martha Shaw, Jeff Allen
Pathological gambling (PG) is a common and costly public health problem associated with impaired quality of life and high suicide rates. Despite its frequency in the general population, PG course is poorly understood in older adults who are especially vulnerable to its devastating consequences. We enrolled 175 subjects in a longitudinal study of gambling behavior: our case group of 53 older adults with PG (≥ 60 years), and two comparison groups including 72 younger adults with PG (< 40 years) and 50 older adults without PG (≥ 60 years)...
June 13, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28639817/a-systematic-review-of-treatments-for-problem-gambling
#12
Nancy M Petry, Meredith K Ginley, Carla J Rash
Gambling problems impact 0.2%-4.0% of the population, and research related to treating gambling has burgeoned in the last decades. This article reviews trials for psychosocial treatments of gambling problems. Using Preferred Reporting Items for Systematic Reviews and Meta-Analyses Standards, we identified 21 randomized trials. Eleven studies evaluated interventions delivered via multisession, in-person therapy: cognitive therapies, cognitive-behavioral (CB) therapies, and motivational interventions (MI) alone or with CB therapies...
June 22, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/28634462/gender-invariance-of-the-gambling-behavior-scale-for-adolescents-gbs-a-an-analysis-of-differential-item-functioning-using-item-response-theory
#13
Maria Anna Donati, Francesca Chiesi, Viola A Izzo, Caterina Primi
As there is a lack of evidence attesting the equivalent item functioning across genders for the most employed instruments used to measure pathological gambling in adolescence, the present study was aimed to test the gender invariance of the Gambling Behavior Scale for Adolescents (GBS-A), a new measurement tool to assess the severity of Gambling Disorder (GD) in adolescents. The equivalence of the items across genders was assessed by analyzing Differential Item Functioning within an Item Response Theory framework...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28631520/striatal-changes-underlie-mpep-mediated-suppression-of-the-acquisition-and-expression-of-pramipexole-induced-place-preference-in-an-alpha-synuclein-rat-model-of-parkinson-s-disease
#14
Simon Loiodice, Portia McGhan, Vitalina Gryshkova, Renaud Fleurance, David Dardou, Aziz Hafidi, Andre Nogueira da Costa, Franck Durif
Impulsive-compulsive disorders in Parkinson's disease patients have been described as behavioural or substance addictions including pathological gambling or compulsive medication use of dopamine replacement therapy. A substantial gap remains in the understanding of these disorders. We previously demonstrated that the rewarding effect of the D2/D3 agonist pramipexole was enhanced after repeated exposure to L-dopa and alpha-synuclein mediated dopaminergic nigral loss with specific transcriptional signatures suggesting a key involvement of the glutamatergic pathway...
June 1, 2017: Journal of Psychopharmacology
https://www.readbyqxmd.com/read/28624877/gambling-motives-do-they-explain-cognitive-distortions-in-male-poker-gamblers
#15
Sasha Mathieu, Servane Barrault, Paul Brunault, Isabelle Varescon
Gambling behavior is partly the result of varied motivations leading individuals to participate in gambling activities. Specific motivational profiles are found in gamblers, and gambling motives are closely linked to the development of cognitive distortions. This cross-sectional study aimed to predict cognitive distortions from gambling motives in poker players. The population was recruited in online gambling forums. Participants reported gambling at least once a week. Data included sociodemographic characteristics, the South Oaks Gambling Screen, the Gambling Motives Questionnaire-Financial and the Gambling-Related Cognition Scale...
June 17, 2017: Journal of Gambling Studies
https://www.readbyqxmd.com/read/28612049/episodic-tags-enhance-striatal-valuation-signals-during-temporal-discounting-in-pathological-gamblers
#16
Antonius Wiehler, Frederike Hermi Petzschner, Klaas Enno Stephan, Jan Peters
Similar to many addiction disorders, pathological gambling is associated with an increased preference for immediate rewards (steep temporal discounting). In healthy participants, episodic future thinking has been shown to reduce impulsivity during intertemporal choice. Here, we examine for the first time a modulation of temporal discounting via episodic future thinking in a group of pathological gamblers. We investigated a sample of 24 pathological gamblers and 24 matched healthy controls with functional magnetic resonance imaging (fMRI)...
May 2017: ENeuro
https://www.readbyqxmd.com/read/28582650/magical-thinking-and-decision-making-strategies-among-late-adolescent-regular-gamblers-a-mediation-model
#17
Alessia Passanisi, Giuseppe Craparo, Ugo Pace
In the present study, the relation between the tendency to seek supernatural connections between external events and one's own thoughts, words, and actions and gambling among late adolescents has been studied. Psychologists have called this tendency magical thinking. The principal aim of the present study was to test the fit of an explanatory model of risk that starts from magical thinking and passes through maladaptive decision-making strategies, culminating with pathological gambling. Two hundred twenty-two Italian late adolescents, regularly attending bingo halls, aged between 19 and 21 years, completed measures on magical thinking, decision-making strategies, and gambling...
August 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/28570912/current-suicidal-ideation-in-treatment-seeking-individuals-in-the-united-kingdom-with-gambling-problems
#18
Silvia Ronzitti, Emiliano Soldini, Neil Smith, Marc N Potenza, Massimo Clerici, Henrietta Bowden-Jones
BACKGROUND: Studies show higher lifetime prevalence of suicidality in individuals with pathological gambling. However, less is known about the relationship between pathological gambling and current suicidal ideation. OBJECTIVES: We investigated socio-demographic, clinical and gambling-related variables associated with suicidality in treatment-seeking individuals. METHODS: Bivariate analyses and logistic regression models were generated on data from 903 individuals to identify measures associated with aspects of suicidality...
May 24, 2017: Addictive Behaviors
https://www.readbyqxmd.com/read/28511259/impulse-control-disorders-and-related-complications-of-parkinson-s-disease-therapy
#19
Alexander M Lopez, Daniel Weintraub, Daniel O Claassen
Impulsive and compulsive behaviors in Parkinson's disease (PD) patients are most often attributed to dopamine agonist therapy; dysregulation of the mesocorticolimbic system accounts for this behavioral phenotype. The clinical presentation is commonly termed impulse control disorder (ICD): Behaviors include hypersexuality, compulsive eating, shopping, pathological gambling, and compulsive hobby participation. However, not all PD individuals taking dopamine agonists develop these behavioral changes. In this review, the authors focus on the similarities between the phenotypic presentation of ICDs with that of other reward-based behavioral disorders, including binge eating disorder, pathological gambling, and substance use disorders...
April 2017: Seminars in Neurology
https://www.readbyqxmd.com/read/28486792/gambling-disorder-an-integrative-review-of-animal-and-human-studies
#20
REVIEW
Katherine M Nautiyal, Mayumi Okuda, Rene Hen, Carlos Blanco
Gambling disorder (GD), previously called pathological gambling and classified as an impulse control disorder in DSM-III and DSM-IV, has recently been reclassified as an addictive disorder in the DSM-5. It is widely recognized as an important public health problem associated with substantial personal and social costs, high rates of psychiatric comorbidity, poor physical health, and elevated suicide rates. A number of risk factors have been identified, including some genetic polymorphisms. Animal models have been developed in order to study the underlying neural basis of GD...
April 2017: Annals of the New York Academy of Sciences
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