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REVIEW
Dixon Yang, Mitchell S V Elkind
INTRODUCTION: Cryptogenic stroke is a heterogeneous entity defined as an ischemic stroke for which no probable cause is identified despite thorough diagnostic evaluation. Since about a quarter of all ischemic strokes are classified as cryptogenic, it is a commonly encountered problem for providers as secondary stroke prevention is guided by stroke etiology. AREAS COVERED: In this review, the authors provide an overview of stroke subtype classification schemes and diagnostic evaluation in cryptogenic stroke...
March 2023: Expert Review of Neurotherapeutics
#22
RANDOMIZED CONTROLLED TRIAL
Taís Flores de Oliveira, Vinicius Serra Peringer, Luiz Alberto Forgiarini Junior, Bruna Eibel
Background and Objectives : Perform the bag squeezing and PEEP-ZEEP techniques associated with manual chest compression in mechanically ventilated cardiac patients in order to observe their effectiveness in the removal of pulmonary secretions and safety from a hemodynamic and ventilatory point of view. Methods: This is a randomized crossover clinical trial developed in a hospital in southern Brazil. We included hemodynamically stable male and female patients aged over 18 years who used invasive mechanical ventilation for at least 48 h...
February 5, 2023: International Journal of Environmental Research and Public Health
#23
JOURNAL ARTICLE
Tenofovir Disoproxil Fumarate Reduces the Severity of COVID-19 in Patients with Chronic Hepatitis B.
Beatriz Mateos-Muñoz, María Buti, Inmaculada Fernández Vázquez, Marta Hernández Conde, Vanesa Bernal-Monterde, Fernando Díaz-Fontenla, Rosa María Morillas, Luisa García-Buey, Ester Badía, Mireia Miquel, Alberto Amador-Navarrete, Sergio Rodríguez-Tajes, Lucía Ramos-Merino, Antonio Madejón, Montserrat García-Retortillo, Juan Ignacio Arenas, Joaquín Cabezas, Jesús Manuel González Santiago, Conrado Fernández-Rodríguez, Patricia Cordero, Moisés Diago, Antonio Mancebo, Alberto Pardo, Manuel Rodríguez, Elena Hoyas, Jose Javier Moreno, Juan Turnes, Miguel Ángel Simón, Cristina Marcos-Fosch, Jose Luis Calleja, Rafael Bañares, Sabela Lens, Javier Garcia-Samaniego, Javier Crespo, Manuel Romero-Gomez, Francisco Gea, Enrique Rodríguez de Santiago, Santiago Moreno, Agustin Albillos
BACKGROUND AND AIMS: HIV-positive patients on tenofovir hydroxyl fumarate (TDF)/emtricitabine have a lower risk of COVID-19 and hospitalization than those given other treatments. Our aim was to analyze the severity of COVID-19 in patients with chronic hepatitis B (CHB) on TDF or entecavir (ETV). METHODS: Spanish hospital databases (n = 28) including information regarding adult CHB patients on TDF or ETV for the period February 1st to November 30th 2020 were searched for COVID-19, defined as a positive SARS-CoV-2 polymerase chain reaction, and for severe COVID-19...
February 3, 2023: Digestive Diseases and Sciences
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JOURNAL ARTICLE
Marta Pepió Espuny, Yolanda Ortega Vila, Enric Aragonès Benaiges, José Fernández Sáez, Meritxell Pallejà Millán, Joan-Josep Cabré Vila
OBJECTIVE: Some bibliography supports a diagnostic and therapeutic delay in women with high cardiovascular risk. The objective of this paper was to know the incidence of cardiovascular disease (CVD) and mortality in a cohort with Metabolic Syndrome (MetS); analyze possible differences in gender and place of residence, regarding the performance of primary angioplasties in patients with ischemic heart disease (IHD). METHODS: Population cohort study, with SIDIAP database (Sistema de Información para la Investigación en Atención Primaria), in primary care in Catalonia...
January 17, 2023: Revista Española de Salud Pública
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JOURNAL ARTICLE
Noemí Villén, Albert Roso-Llorach, Carlos Gallego-Moll, Marc Danes-Castells, Sergio Fernández-Bertolin, Amelia Troncoso-Mariño, Monica Monteagudo, Ester Amado, Concepción Violán
(1) Introduction: Cardiovascular disease is associated with high mortality, especially in older people. This study aimed to characterize the evolution of combined multimorbidity and polypharmacy patterns in older people with different cardiovascular disease profiles. (2) Material and methods: This longitudinal study drew data from the Information System for Research in Primary Care in people aged 65 to 99 years with profiles of cardiovascular multimorbidity. Combined patterns of multimorbidity and polypharmacy were analysed using fuzzy c-means clustering techniques and hidden Markov models...
December 13, 2022: Geriatrics
#26
Loa Ambroise Gnaba, Kassi Anicet Adoubi, Kouakou Florent Diby, Isabelle Kouamé, Pinnin Evelyne Adjara Ouattara, Manga Diomandé, Mbe Matokoma Daniogo, Keumian Gabin Tro, Koudré Serge Armel Dakoi, Aka Roland N'Guetta
Abnormalities in the aVR lead would provide useful information on the risk of coronary heart disease. This clinical case is an illustration. Indeed, this is a 60-year-old patient, an active smoker and a former type 2 diabetic who presented with angina-like chest pain with a positive stress test. The initial electrocardiogram showed a discreet elevation of the ST segment and an aVR necrosis Q wave with mirror signs in the inferior territory. An ischemic heart disease with altered ventricular ejection fraction was objectified...
2022: Pan African Medical Journal
#27
JOURNAL ARTICLE
Geovedy Martinez-Garcia, Miguel Rodriguez-Ramos, Maikel Santos-Medina, Annia Maria Carrero-Vazquez, Yanitsy Chipi-Rodriguez
INTRODUCTION AND OBJECTIVES: Ischemic cardiopathy constitutes the leading cause of death worldwide. Our aim was to evaluate the prognostic capacity of the leukoglycemic index as well as to create a predictive model of in-hospital complications in patients with ST elevation myocardial infarction. MATERIALS AND METHODS: This was a multicentral and cohort study, which included patients inserted in the Cuban Registry of acute myocardial infarction. The study investigated 900 patients with a validation population represented by 233 external subjects...
2022: Discoveries
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JOURNAL ARTICLE
David X Zhao, Emma Gootee, Michelle C Johansen
Objective: Cerebral microbleeds (CMB) are small accumulations of hemosiderin associated with cerebrovascular risk factors, but whether they are associated with atrial cardiopathy is not known. The goal of this study is to determine, among ischemic stroke patients, the association between study-defined atrial cardiopathy and CMB presence, location, and number. Methods: Ischemic stroke patients admitted to Johns Hopkins (2015-2019) with transthoracic echocardiography and electrocardiography were included...
2022: Frontiers in Neurology
#29
JOURNAL ARTICLE
Gisela Tinone, Mauricio Hoshino, Leandro Lucato, Luiz Roberto Comerlatti
In 2019, the American Heart Association did not recommend the emergent use of anticoagulation to prevent recurrence or progression of acute ischemic stroke. However, its indication in patients with extracranial artery intraluminal thrombus with artery-to-artery cerebral embolization must be analyzed. In this article, we will also discuss other indications of anticoagulation. This treatment could be indicated in patients with ischemic stroke caused by embolization from cervical artery dissection, catastrophic antiphospholipid antibodies syndrome (APS) and some cases of Covid 19...
May 2022: Arquivos de Neuro-psiquiatria
#30
JOURNAL ARTICLE
Muhammad Imtiaz Ahmad, Luqman-Arafath Tk, Muhammad Ali Anees, Lin Yee Chen, Elsayed Z Soliman
The link between abnormal P-wave axis (aPWA) and incident ischemic stroke is well established. However, studies examining the association between aPWA and fatal stroke are rare. We hypothesized that aPWA is associated with fatal stroke. We examined the association of abnormal aPWA with stroke mortality in 7,359 participants (60.0 ± 13.4 years, 51.9% women, 49.8% White) without cardiovascular (CV) disease (CVD) from the Third National Health and Nutrition Examination Survey. aPWA was defined as any value <0 or >75° ...
August 6, 2022: American Journal of Cardiology
#31
JOURNAL ARTICLE
Lucie Garnier, Gauthier Duloquin, Alexandre Meloux, Karim Benali, Audrey Sagnard, Mathilde Graber, Geoffrey Dogon, Romain Didier, Thibaut Pommier, Catherine Vergely, Yannick Béjot, Charles Guenancia
BACKGROUND: Intensive screening for atrial fibrillation (AF) has led to a better recognition of this cause in stroke patients. However, it is currently debated whether AF Detected After Stroke (AFDAS) has the same pathophysiology and embolic risk as prior-to-stroke AF. We thus aimed to systematically approach AFDAS using a multimodal approach combining clinical, imaging, biological and electrocardiographic markers. METHODS: Patients without previously known AF admitted to the Dijon University Hospital (France) stroke unit for acute ischemic stroke were prospectively enrolled...
2022: Frontiers in Cardiovascular Medicine
#32
JOURNAL ARTICLE
Maurizio Acampa, Alessandra Cartocci, Carlo Domenichelli, Rossana Tassi, Francesca Guideri, Pietro Enea Lazzerini, Giuseppe Martini
Background and Purpose: The current definition of embolic strokes of undetermined source (ESUS) seems to be too broad, including strokes due to heterogeneous mechanisms, such as atrial cardiopathy and other occult cardiac conditions, aortic arch plaques, and non-stenosing atherosclerosis, that can be differently associated with clinical stroke severity at the time of presentation. The aim of our study was to assess the possible association between neurological deficit severity and presence of markers of atrial cardiopathy in ESUS...
2022: Frontiers in Cardiovascular Medicine
#33
JOURNAL ARTICLE
Yan Hou, Ahmed Elmashad, Ilene Staff, Mark Alberts, Amre Nouh
INTRODUCTION: Understanding the potential embolic source in young patients with ESUS may improve the diagnosis and treatment of such patients. HYPOTHESIS: Potential embolic sources (PES) differ in young vs. older patients with ESUS, and, therefore, not all patients with ESUS have the same risk profile for stroke recurrence. METHODS: Young patients (age 18-49) with ESUS, who were admitted to our stroke center from 2006 to 2019, were identified retrospectively and matched with next consecutive older patients (age 50-99) with ESUS by admission date...
2022: Frontiers in Neurology
#34
JOURNAL ARTICLE
Patrizia Toia, Erica Maffei, Cesare Mantini, Giuseppe Runza, Ludovico La Grutta, Emanuele Grassedonio, Andrea Guaricci, Bruna Punzo, Carlo Cavaliere, Filippo Cademartiri
Cardiac Magnetic Resonance (CMR) allows an accurate Right Ventricle (RV) assessment that could be of great relevance in diseases causing inflammation or fibrosis. The aim of this study was to evaluate the concomitant involvement of the RV in patients with delayed enhancement (DE) of the Left Ventricle (LV-DE) using CMR. We retrospectively enrolled 95 (male n. 66; age 55±18years; BMI 26±5kg/m2) consecutive patients with LV-DE who underwent a CMR (Achieva 1.5 T, Philips) for different indications: post-ischemic dilated cardiopathy (PDM), hypertrophic cardiomyopathy (HCM), myocardial infarction (MI), myocarditis/pericarditis (MP) and congenital heart disease (CD)...
May 11, 2022: Acta Bio-medica: Atenei Parmensis
#35
JOURNAL ARTICLE
Isabel Monedero-Sánchez, Pablo Robles-Velasco, Elia Pérez-Fernández, Amador Rubio-Caballero, Cecilia Marco-Quirós, Victoria Espejo-Bares, Verónica Artiaga-de-la-Barrera, Carla Jiménez-Martínez, Carlos García-Jiménez, Pablo González-Alirangues
Objective: From the onset of COVID-19 pandemic, the presence of previous cardiopathy was thought to be related with a worse prognosis of the disease. We aimed to analyse that theoretical adverse impact in a large cohort of patients. Method: We selected 1065 patients admitted for SARS-CoV-2 pneumonia between March and June 2020, divided in three groups according to (1) absence of cardiopathy, (2) presence of valvular heart disease or ischemic heart disease, or (3) presence of heart failure...
April 20, 2022: Archivos de Cardiología de México
#36
JOURNAL ARTICLE
Batric Popovic, Jeanne Varlot, Joseph Hennequin, Pierre Adrien Metzdorf, Nicolas Jay, Edoardo Camenzind, Aurélie Bannay
BACKGROUND: Patients with chronic inflammatory conditions are at an increased risk of developing atherothrombotic events. We aimed to assess the 1-year prognosis after myocardial infarction (MI) in patients with inflammatory bowel disease (IBD). METHODS: From the PMSI (Program de Medicalisation des Systèmes d'informatique) database, 246 out of 39,835 consecutive MI patients, hospitalized between 2012 and 2017, were diagnosed with IBD and followed up for 1 year after discharge...
April 9, 2022: Heart and Vessels
#37
JOURNAL ARTICLE
Yuye Ning, Meng Wei, Wenfeng Song, Guogang Luo
Objective: To compare the proportion of atrial cardiopathy in patients with embolic stroke of undetermined source (ESUS) and other non-cardiac strokes, and to evaluate the prognostic value of atrial cardiopathy biomarkers in patients with ESUS. Methods: This retrospective study enrolled patients with ischemic stroke from January 2018 to April 2020 in a single stroke center, and compared the proportion of atrial cardiopathy in (1) ESUS group, (2) large artery atherosclerosis (LAA) group, and (3) small-vessel occlusion (SVO) group...
2022: Frontiers in Cardiovascular Medicine
#38
JOURNAL ARTICLE
Dana L Ionel, Fred O Odago, Andre N Ene, Jessica D Lee, William N O'Connor, Larry B Goldstein, L Creed Pettigrew
Non-traumatic neurological deterioration is a medical emergency that may arise from diverse causes, to include cerebral infarction or intracranial hemorrhage, meningoencephalitis, seizure, hypoxic-ischemic or toxic/metabolic encephalopathy, poisoning, or drug intoxication. We describe the abrupt onset of neurological deterioration in a 53-year-old man with Williams-Beuren syndrome, a sporadically occurring genetic disorder caused by chromosomal microdeletion at 7q11.23. The clinical phenotype of Williams-Beuren syndrome is suggested by distinctive elfin facies, limited intellect, unique personality features, growth abnormalities, and endocrinopathies...
April 2022: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
#39
JOURNAL ARTICLE
Roberto Cañete, José A Afonso, Katia Brito
Background: The ongoing Covid-19 pandemic is a worldwide public health threat. Millions of people are at risk and older adults are more susceptible to developing the most serious manifestations of the disease, in part because the ageing of the immune system. Biomodulina T® is an injectable immune modulator that has been licensed for use in Cuba for many years. An open-label, uncontrolled trial was conducted to investigate whether it might be useful to prevent or modulate the serious effects of SARS-CoV-2 infections in older Cuban adults prior to the availability of vaccinations...
January 12, 2022: Current Therapeutic Research, Clinical and Experimental
#40
JOURNAL ARTICLE
Luciano A Sposato, Seemant Chaturvedi, Cheng-Yang Hsieh, Carlos A Morillo, Hooman Kamel
Atrial fibrillation (AF) can be newly detected in approximately one-fourth of patients with ischemic stroke and transient ischemic attack without previously recognized AF. We present updated evidence supporting that AF detected after stroke or transient ischemic attack (AFDAS) may be a distinct clinical entity from AF known before stroke occurrence (known atrial fibrillation). Data suggest that AFDAS can arise from the interplay of cardiogenic and neurogenic forces. The embolic risk of AFDAS can be understood as a gradient defined by the prevalence of vascular comorbidities, the burden of AF, neurogenic autonomic changes, and the severity of atrial cardiopathy...
March 2022: Stroke; a Journal of Cerebral Circulation
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