keyword
https://read.qxmd.com/read/38424011/rapid-critical-care-training-for-nurses-deployed-to-intensive-care-units-during-the-covid-19-surge
#21
JOURNAL ARTICLE
Susan I Liu, Andrew Greenway, Kathryn Sobocinski, Anjile An, Robert J Winchell, Philip S Barie
BACKGROUND: During the first COVID-19 pandemic wave, non-intensive care unit (non-ICU) nurses were deployed to temporary ICUs to provide critical care for the patient surge. A rapid critical care training program was designed to prepare them to care for patients in either temporary or permanent ICUs. OBJECTIVE: To evaluate the effectiveness of this training program in preparing non-ICU nurses to provide critical care for COVID-19 patients in temporary ICUs. METHODS: A survey was used to evaluate the impact of rapid critical care training on nurses' critical care skills and compare the experiences of nurses deployed to temporary versus permanent ICUs...
March 1, 2024: American Journal of Critical Care
https://read.qxmd.com/read/38422769/multi-centers-experience-using-therapeutic-plasma-exchange-for-corticosteroid-tocilizumab-refractory-cytokine-release-syndrome-following-car-t-therapy
#22
JOURNAL ARTICLE
Yedi Pu, Yifan Zhao, Yuekun Qi, Yang Liu, Meng Zhang, Xia Xiao, Hairong Lyu, Juanxia Meng, Haibo Zhu, Kailin Xu, Weidong Han, Mingfeng Zhao
The chimeric antigen receptor T (CAR-T) cell therapy significantly enhances the prognosis of various hematologic malignancies; however, the systemic expansion of CAR-T cells also gives rise to severe cytokine release syndrome (CRS), and immune effector cell-associated neurotoxicity syndrome (ICANS). Despite the successful application of corticosteroids and tocilizumab in alleviating severe CRS in most patients, there are still individuals who experience life-threatening CRS without responding to the aforementioned therapies...
February 28, 2024: International Immunopharmacology
https://read.qxmd.com/read/38420581/intraintestinal-fermentation-of-fructo-and-galacto-oligosaccharides-and-the-fate-of-short-chain-fatty-acids-in-humans
#23
JOURNAL ARTICLE
Mara P H van Trijp, Melany Rios-Morales, Ben Witteman, Fentaw Abegaz, Albert Gerding, Ran An, Martijn Koehorst, Bernard Evers, Katja C V van Dongen, Erwin G Zoetendal, Henk Schols, Lydia A Afman, Dirk-Jan Reijngoud, Barbara M Bakker, Guido J Hooiveld
Consumption of fructo- (FOS) and galacto-oligosaccharides (GOS) has health benefits which have been linked in part to short-chain fatty acids (SCFA) production by the gut microbiota. However, detailed knowledge of this process in the human intestine is lacking. We aimed to determine the acute fermentation kinetics of a FOS:GOS mixture in healthy males using a naso-intestinal catheter for sampling directly in the ileum or colon. We studied the fate of SCFA as substrates for glucose and lipid metabolism by the host after infusion of 13 C-SCFA...
March 15, 2024: IScience
https://read.qxmd.com/read/38419599/optimal-starting-dosing-regimen-of-intravenous-oxytocin-for-labor-induction-based-on-the-population-kinetic-pharmacodynamic-model-of-uterine-contraction-frequency
#24
JOURNAL ARTICLE
Zhiheng Yu, Rong Chen, Cheng Zhao, Renwei Zhang, Tianyan Zhou, Yangyu Zhao
BACKGROUND: Intravenous oxytocin is commonly used for labor induction. However, a consensus on the initial dosing regimen is lac with conflicting research findings and varying guidelines. This study aimed to develop a population kinetic-pharmacodynamic (K-PD) model for oxytocin-induced uterine contractions considering real-world data and relevant influencing factors to establish an optimal starting dosing regimen for intravenous oxytocin. METHODS: This retrospective study included pregnant women who underwent labor induction with intravenous oxytocin at Peking University Third Hospital in 2020...
February 29, 2024: Pharmacotherapy
https://read.qxmd.com/read/38417086/virus-specific-t-cells-for-the-treatment-of-systemic-infections-following-allogeneic-hematopoietic-cell-and-solid-organ-transplantation
#25
JOURNAL ARTICLE
Abby Green, Jeremy D Rubinstein, Michael Grimley, Thomas Pfeiffer
Viral infections are a major source of morbidity and mortality in the context of immune deficiency and immunosuppression following allogeneic hematopoietic cell (allo-HCT) and solid organ transplantation (SOT). The pharmacological treatment of viral infections is challenging and often complicated by limited efficacy, the development of resistance, and intolerable side effects. A promising strategy to rapidly restore antiviral immunity is the adoptive transfer of virus-specific T cells (VST). This therapy involves the isolation and ex vivo expansion or direct selection of antigen-specific T cells from healthy seropositive donors, followed by infusion into the patient...
February 28, 2024: Journal of the Pediatric Infectious Diseases Society
https://read.qxmd.com/read/38417030/ptp1b-phosphatase-dampens-ipsc-derived-neutrophil-motility-and-antimicrobial-function
#26
JOURNAL ARTICLE
Morgan A Giese, David A Bennin, Taylor J Schoen, Ashley N Peterson, Jonathan H Schrope, Josh Brand, Ho Sun Jung, Nancy P Keller, David J Beebe, Huy Q Dinh, Igor I Slukvin, Anna Huttenlocher
Neutrophils are rapidly recruited to sites of infection and are critical for pathogen clearance. Therapeutic use of primary neutrophils has been limited as they have a short lifespan and are not amenable to genetic manipulation. Human induced pluripotent stem cells (iPSCs) can provide a robust source of neutrophils for infusion and are genetically tractable. However, current work has indicated that dampened intracellular signaling limits iPSC-derived neutrophil (iNeutrophil) cellular activation and antimicrobial response...
February 28, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38415776/filamentous-fungal-pellets-as-a-novel-and-sustainable-encapsulation-matrix-for-exogenous-bioactive-compounds
#27
JOURNAL ARTICLE
Yixing Lu, Minami Ogawa, Jaime Moreno García, Nitin Nitin
Edible filamentous fungi (FF) are considered sustainable food materials given their rich nutrient profile and low carbon and water footprints during production. The current study evaluated FF biomass as a natural encapsulation system for exogenous bioactive compounds and as a model system to investigate the complex food matrix-micronutrient interactions during in vitro digestion. Our objective was to compare the fungal pellet, as a multicellular encapsulation system, with single yeast cell-based carriers in terms of loading and release of curcumin, a model compound...
February 28, 2024: Food & Function
https://read.qxmd.com/read/38412953/-anticoagulant-rodenticide-poisoning-in-dogs-retrospective-analysis-of-clinical-and-laboratory-diagnostic-data
#28
JOURNAL ARTICLE
Anna Frommeyer, Reinhard Mischke
OBJECTIVE: In this retrospective study, patient records of dogs suffering from poisoning with coumarin derivatives were evaluated to characterize the clinical appearance more precisely. MATERIAL UND METHODS: Retrospective data analysis included 52 dogs with hemostaseologically proven anticoagulant rodenticide poisoning which were treated as inpatients at the Clinic for Small Animals between September 2011 and October 2018. RESULTS: In only 2 dogs (4%) the intake of poison could be observed with certainty...
February 2024: Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere
https://read.qxmd.com/read/38411891/diagnosis-and-management-of-secondary-adrenal-crisis
#29
REVIEW
Luciana Martel-Duguech, Jonathan Poirier, Isabelle Bourdeau, André Lacroix
Adrenal crisis (AC) is a life threatening acute adrenal insufficiency (AI) episode which can occur in patients with primary AI but also secondary AI (SAI), tertiary AI (TAI) and iatrogenic AI (IAI). In SAI, TAI and IAI, AC may develop when the HPA axis is unable to mount an adequate glucocorticoid response to severe stress due to pituitary or hypothalamic disruption. It manifests as an acute deterioration in multi-organ homeostasis that, if untreated, leads to shock and death. Despite the availability of effective preventive strategies, its prevalence is increasing in patients with SAI, TAI and IAI due to more frequent exogenous steroid administration, pituitary immune-related effects of immune checkpoint inhibitors and opioid use in pain management...
February 27, 2024: Reviews in Endocrine & Metabolic Disorders
https://read.qxmd.com/read/38408253/magnetically-powered-microwheel-thrombolysis-of-occlusive-thrombi-in-zebrafish
#30
JOURNAL ARTICLE
M Hao Hao Pontius, Chia-Jui Ku, Matthew J Osmond, Dante Disharoon, Yang Liu, Mark Warnock, Daniel A Lawrence, David W M Marr, Keith B Neeves, Jordan A Shavit
Tissue plasminogen activator (tPA) is the only FDA-approved treatment for ischemic stroke but carries significant risks, including major hemorrhage. Additional options are needed, especially in small vessel thrombi which account for ~25% of ischemic strokes. We have previously shown that tPA-functionalized colloidal microparticles can be assembled into microwheels (µwheels) and manipulated under the control of applied magnetic fields to enable rapid thrombolysis of fibrin gels in microfluidic models of thrombosis...
March 5, 2024: Proceedings of the National Academy of Sciences of the United States of America
https://read.qxmd.com/read/38399760/effects-of-resistant-starch-infusion-solely-and-mixed-with-xylan-or-cellulose-on-gut-microbiota-composition-in-ileum-cannulated-pigs
#31
JOURNAL ARTICLE
Yaowen Zhang, Yu Bai, Zhenyu Wang, Hao Ye, Dandan Han, Jinbiao Zhao, Junjun Wang, Defa Li
Fermentation of dietary fiber (DF) is beneficial for gut health, but its prebiotic effects are often impeded in the distal large intestine because of the fast degradation of fermentable substrates. One way to enhance the prebiotic effect of DF is to deliver fibers to the lower parts of the gut, which can be achieved by mixing different kinds of fiber. Therefore, in the present study, an ileum-cannulated pig model was employed to investigate the fermentation influence in the large intestine by infusing resistant starch solely (RS, fast fermentable fiber) and mixing with other fibers (xylan or cellulose)...
February 9, 2024: Microorganisms
https://read.qxmd.com/read/38395779/external-validation-of-the-modified-marsh-and-schnider-models-for-medium-chain-triglyceride-propofol-in-target-controlled-infusion-anesthesia
#32
JOURNAL ARTICLE
Seongheon Lee, Dongho Kang, Eunjin Song, Sungah Yoo, Seongwook Jeong
BACKGROUND: Propofol formulated with medium- and long-chain triglycerides (MCT/LCT propofol) has rapidly replaced propofol formulated with long-chain triglycerides (LCT propofol). Despite this shift, the modified Marsh and Schnider pharmacokinetic models developed using LCT propofol are still widely used for target-controlled infusion (TCI) of propofol. This study aimed to validate the external applicability of these models by evaluating their predictive performance during TCI of MCT/LCT propofol in general anesthesia...
February 23, 2024: BMC Anesthesiology
https://read.qxmd.com/read/38394548/perioperative-care-of-neonates-with-critical-pulmonary-stenosis-case-report
#33
JOURNAL ARTICLE
Qiong He, Min Song, Yanping Huang, Ling Wan
RATIONALE: Summarizing the perioperative nursing experience in the successful treatment of 4 neonates with critical pulmonary stenosis (CPS). PATIENT CONCERNS: Of the 4 patients, 3 had postnatal shortness of breath and varying degrees of cyanosis, aggravated by crying and noise, and 1 had no obvious shortness of breath and cyanosis. The preoperative auscultation of the precordial region could be heard 3-4/6 systolic murmur; echocardiography was diagnosed as CPS, combined with patent ductus arteriosus, right ventricular dysplasia, and severe tricuspid regurgitation...
February 23, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38390952/elimination-of-intracellular-ca-2-overload-by-bapta%C3%A2-am-liposome-nanoparticles-a-promising-treatment-for-acute-pancreatitis
#34
JOURNAL ARTICLE
Zailin Fu, Dingsheng Wang, Caiyun Zheng, Minghua Xie, Yifang Chen, Yi Zhou, Yan Huang, Ying Song, Weiyong Hong
Calcium overload, a notable instigator of acute pancreatitis (AP), induces oxidative stress and an inflammatory cascade, subsequently activating both endogenous and exogenous apoptotic pathways. However, there is currently lack of available pharmaceutical interventions to alleviate AP by addressing calcium overload. In the present study, the potential clinical application of liposome nanoparticles (LNs) loaded with 1,2‑bis(2‑aminophenoxy)ethane‑N,N,N',N'‑tetraacetic acid tetrakis (acetoxymethyl ester) (BAPTA‑AM), a cell‑permeant calcium chelator, was investigated as a therapeutic approach for the management of AP...
April 2024: International Journal of Molecular Medicine
https://read.qxmd.com/read/38384458/adoptive-cell-therapy-for-high-grade-gliomas-using-simultaneous-temozolomide-and-intracranial-mgmt-modified-%C3%AE-%C3%AE-t-cells-following-standard-post-resection-chemotherapy-and-radiotherapy-current-strategy-and-future-directions
#35
JOURNAL ARTICLE
L B Nabors, L S Lamb, T Goswami, K Rochlin, S L Youngblood
Cellular therapies, including chimeric antigen receptor T cell therapies (CAR-T), while generally successful in hematologic malignancies, face substantial challenges against solid tumors such as glioblastoma (GBM) due to rapid growth, antigen heterogeneity, and inadequate depth of response to cytoreductive and immune therapies, We have previously shown that GBM constitutively express stress associated NKG2D ligands (NKG2DL) recognized by gamma delta (γδ) T cells, a minor lymphocyte subset that innately recognize target molecules via the γδ T cell receptor (TCR), NKG2D, and multiple other mechanisms...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38383903/a-dose-ranging-study-of-the-physiological-and-self-reported-effects-of-repeated-rapid-infusion-of-remifentanil-in-people-with-opioid-use-disorder-and-physical-dependence-on-fentanyl
#36
JOURNAL ARTICLE
Joshua A Lile, Thomas P Shellenberg, Shanna Babalonis, Kevin W Hatton, Lon R Hays, Abner O Rayapati, William W Stoops, Michael J Wesley
RATIONALE: Understanding mechanisms of drug use decisions will inform the development of treatments for opioid use disorder (OUD). Decision-making experiments using neurobehavioral approaches require many trials or events of interest for statistical analysis, but the pharmacokinetics of most opioids limit dosing in humans. OBJECTIVES: This experiment characterized the effects of repeated infusions of the ultra-short acting opioid remifentanil in people with OUD and physical opioid dependence...
February 22, 2024: Psychopharmacology
https://read.qxmd.com/read/38381555/lipid-encapsulated-mrnas-encoding-complex-fusion-proteins-potentiate-anti-tumor-immune-responses
#37
JOURNAL ARTICLE
Casey W Shuptrine, Yuhui Chen, Jayalakshmi Miriyala, Karen Lenz, Danielle Moffett, Thuy-Ai Nguyen, Jenn Michaux, Kristen Campbell, Connor Smith, Marc Morra, Yisel Rivera-Molina, Noah Murr, Sarah Cooper, Ashlyn McGuire, Vishruti Makani, Nathan Oien, Jeffrey T Zugates, Suresh de Silva, Taylor H Schreiber, Seymour de Picciotto, George Fromm
Lipid nanoparticle (LNP)-encapsulated mRNA has been used for in vivo production of several secreted protein classes, such as IgG, and has enabled the development of personalized vaccines in oncology. Establishing the feasibility of delivering complex multi-specific modalities that require higher-order structures important for their function could help expand the use of mRNA/LNP biologic formulations. Here, we evaluated whether in vivo administration of mRNA/LNP formulations of SIRPα-Fc-CD40L and TIGIT-Fc-LIGHT could achieve oligomerization and extend exposure, on-target activity, and anti-tumor responses comparable to that of the corresponding recombinant fusion proteins...
February 21, 2024: Cancer Research
https://read.qxmd.com/read/38380218/diabetic-ketoacidosis-and-hypertriglyceridemia-induced-acute-pancreatitis-requiring-plasmapheresis-a-case-report-of-a-rare-presentation-of-type-2-diabetes-mellitus-in-adults
#38
João Lourinho, José Proença, Letícia Santos, Vanessa Leite, Sara Ramalho, Conceição Escarigo
The triad of diabetic ketoacidosis, hypertriglyceridemia, and acute pancreatitis is a rare presentation of diabetes mellitus type 2 in adults. We report a case of a 41-year-old male who presented at the emergency department with a sudden onset of severe abdominal pain. Diagnosis of diabetic ketoacidosis, hypertriglyceridemia, and acute pancreatitis was made. Triglyceride level was 6056 mg/dL and glycated hemoglobin was 12.6%. Vigorous fluid therapy and continuous infusion of insulin were started, but due to maintained symptoms, a single plasmapheresis session was performed, with significant clinical improvement...
January 2024: Curēus
https://read.qxmd.com/read/38379558/case-report-extracorporeal-life-support-as-a-successful-bridge-to-recovery-in-an-incident-case-of-pulmonary-arterial-hypertension
#39
Benjamin Pequignot, Ari Chaouat, François Chabot, Bruno Levy, Simon Valentin
Pulmonary arterial hypertension (PAH) is characterized by a progressive increase in pulmonary vascular resistance (PVR) due to vascular remodeling of the small pulmonary arteries. In advanced RV failure or severe hypoxemia, extra corporeal life support (ECLS) is now to be considered, with the objective to bridge patients back to their baseline clinical state while waiting or right after lung transplantation, or bridge to pharmacological optimization of PAH (i.e., bridge to recovery). We describe herein a case of a 30-year-old woman ( gravida 6, para 6) with an incident case of heritable PAH revealed by refractory hypoxemia...
2024: Frontiers in Medicine
https://read.qxmd.com/read/38367449/in-silico-study-of-combination-thrombolytic-therapy-with-alteplase-and-mutant-pro-urokinase-for-fibrinolysis-in-ischemic-stroke
#40
JOURNAL ARTICLE
Yilin Yang, Boram Gu, Xiao Yun Xu
The synergistic advantage of combining tissue plasminogen activator (tPA) with pro-urokinase (proUK) for thrombolysis has been demonstrated in several in vitro experiments, and a single site proUK mutant (m-proUK) has been developed for better stability in plasma. Based on these studies, combination thrombolytic therapy with intravenous tPA and m-proUK has been suggested as a promising treatment for patients with ischemic stroke. This paper evaluates the efficacy and safety of the dual therapy by computational simulations of pharmacokinetics and pharmacodynamics coupled with a local fibrinolysis model...
February 13, 2024: Computers in Biology and Medicine
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