keyword
https://read.qxmd.com/read/38490927/port-a-randomized-cross-over-phase-2-study-of-melflufen-peripheral-versus-central-intravenous-administration-in-patients-with-relapsed-refractory-multiple-myeloma
#1
JOURNAL ARTICLE
Ludek Pour, Ilina Micheva, Ganna Usenko, Gabor Mikala, Tamas Masszi, Kameliya Simeonova, Marcus Thuresson, Gunilla Huledal, Stefan Norin, Nicolaas A Bakker, Jiri Minarik
BACKGROUND: Melflufen, a first-in-class alkylating peptide-drug conjugate, rapidly enters tumor cells and metabolizes to melphalan. In previous studies, melflufen was administered via central venous catheter (CVC). However, administration by peripheral venous catheter (PVC) may be preferable. PATIENTS AND METHODS: PORT was a two-period, phase 2 crossover study of CVC versus PVC melflufen administration in patients with relapsed/refractory multiple myeloma. Adults with ≥ 2 prior therapies refractory to/intolerant of an immunomodulatory drug and a proteasome inhibitor were randomized 1:1 to weekly oral dexamethasone plus melflufen (40 mg) via CVC or PVC infusion on day 1 of 28-day cycle 1...
February 23, 2024: Clinical Lymphoma, Myeloma & Leukemia
https://read.qxmd.com/read/38490703/warfarin-induced-spontaneous-gastric-intramural-haematoma-presenting-with-palpitations
#2
JOURNAL ARTICLE
Chun Ho Szeto, Joud Enabi, Alejandra Garcia Fernandez
Spontaneous gastric intramural haematoma is an uncommon complication associated with anticoagulant therapy. A patient receiving chronic warfarin for paroxysmal atrial fibrillation was admitted due to atrial fibrillation with rapid ventricular response (RVR). An incidental intra-abdominal mass was detected on a CT scan. Following the initiation of the amiodarone infusion, the patient experienced bleeding attributed to warfarin-amiodarone-induced coagulopathy, with no identifiable bleeding source. Subsequent CT scans revealed an enlargement of the intra-abdominal mass, suggesting gastric intramural haematoma...
March 15, 2024: BMJ Case Reports
https://read.qxmd.com/read/38487336/rapid-response-of-thyroid-eye-disease-peripheral-edema-and-acropathy-to-teprotumumab-infusion
#3
David A Kelly, Roger E Turbin
PURPOSE: We present a case of rapid improvement in symptoms of thyroid eye disease and amelioration of worsening peripheral edema and acropathy with infusion of teprotumumab, a monoclonal antibody targeting the insulin-like growth factor-1 receptor. OBSERVATIONS: A 66 year old female with history of Hashimoto thyroiditis developed progressive thyroid eye disease (TED), peripheral edema, and acropathy attributable to acute Graves disease. Her signs and symptoms, refractory to oral steroid and diuretic therapy, rapidly improved following a standard dosing regimen of teprotumumab (one infusion 10 mg/kg then seven infusions 20 mg/kg) to resolution...
June 2024: American Journal of Ophthalmology Case Reports
https://read.qxmd.com/read/38487325/case-report-acute-hhv6b-encephalitis-myelitis-post-car-t-cell-therapy-in-patients-with-relapsed-refractory-aggressive-b-cell-lymphoma
#4
Ningwen Li, Ruoxuan Zhang, Jue Wang, Xiaojian Zhu, Fankai Meng, Yang Cao, Gaoxiang Wang, Yang Yang
BACKGROUND: The development of chimeric antigen receptor (CAR)-T cell therapy has revolutionized treatment outcomes in patients with lymphoid malignancies. However, several studies have reported a relatively high rate of infection in adult patients following CD19-targeting CAR T-cell therapy, particularly in the first 28 days. Notably, acute human herpesvirus 6 B (HHV6B) reactivation occurs in up to two-thirds of allogeneic hematopoietic stem cell transplantation patients. CASE PRESENTATIONS: Herein, we describe a report of HHV6B encephalitis/myelitis in three patients with relapsed/refractory diffuse large B-cell lymphoma post CAR T-cell therapy...
2024: Frontiers in Neurology
https://read.qxmd.com/read/38481366/the-impact-of-omidubicel-on-immune-reconstitution-and-infections-in-cord-blood-transplant-patients
#5
JOURNAL ARTICLE
Hong De Sa, Richard T Maziarz, Arpita P Gandhi
INTRODUCTION: The success of an allogeneic hematopoietic stem cell transplantation (alloHCT) is measured by cure from the underlying malignancy, immune reconstitution (IR), and freedom from graft-versus-host disease, without the continued need for immunosuppressive therapy. AREAS COVERED: Effective IR is critical to the success of alloHCT wherein poor IR can potentially increase the risk of infection and disease relapse. Different stem cell sources give rise to varying patterns of IR...
March 14, 2024: Expert Opinion on Biological Therapy
https://read.qxmd.com/read/38479029/sustainable-beeswax-modified-cellulose-paper-for-the-determination-of-tricyclic-antidepressants-in-biofluids
#6
JOURNAL ARTICLE
Marisol González-Bermúdez, Ángela I López-Lorente, Rafael Lucena, Soledad Cárdenas
This article describes the synthesis of sorptive phases for bioanalysis based on the modification of cellulose paper with natural beeswax as sorbent, resulting in a substrate completely renewable and sustainable. The preparation of the sorptive phases consisted of the dissolution of beeswax in hexane, followed by its drop-casting on cellulose paper and subsequent evaporation of the solvent. The beeswax modification of paper renders it hydrophobic, enabling the extraction of the target analytes, i.e., imipramine, desipramine, amitriptyline and trimipramine, via hydrophobic interactions...
March 1, 2024: Talanta
https://read.qxmd.com/read/38477966/intraventricular-carv3-team-e-t-cells-in-recurrent-glioblastoma
#7
JOURNAL ARTICLE
Bryan D Choi, Elizabeth R Gerstner, Matthew J Frigault, Mark B Leick, Christopher W Mount, Leonora Balaj, Sarah Nikiforow, Bob S Carter, William T Curry, Kathleen Gallagher, Marcela V Maus
In this first-in-human, investigator-initiated, open-label study, three participants with recurrent glioblastoma were treated with CARv3-TEAM-E T cells, which are chimeric antigen receptor (CAR) T cells engineered to target the epidermal growth factor receptor (EGFR) variant III tumor-specific antigen, as well as the wild-type EGFR protein, through secretion of a T-cell-engaging antibody molecule (TEAM). Treatment with CARv3-TEAM-E T cells did not result in adverse events greater than grade 3 or dose-limiting toxic effects...
March 13, 2024: New England Journal of Medicine
https://read.qxmd.com/read/38477185/brain-derived-neurotrophic-factor-val66met-and-cyp2b6-polymorphisms-as-predictors-for-ketamine-effectiveness-in-patients-with-treatment-resistant-depression
#8
JOURNAL ARTICLE
Nelson B Rodrigues, David Chen-Li, Joshua D Di Vincenzo, Ashwin Juneja, Benjamin D Pinder, Roger S McIntyre, Joshua D Rosenblat
BACKGROUND: Converging lines of evidence indicate that ketamine is a rapid antidepressant for individuals with treatment-resistant depression. Hitherto, no reliable a priori predictors of ketamine response have been reported. Pharmacogenetic biomarkers have yielded mixed results regarding potential candidate genes associated with ketamine's biochemistry as reliable predictors of response. AIMS: No studies have examined the effects of Val66Met and CYP2B6 genotypes on patients receiving repeated infusions of intravenous ketamine...
March 13, 2024: Journal of Psychopharmacology
https://read.qxmd.com/read/38464956/dexmedetomidine-target-controlled-infusion-for-awake-craniotomy-%C3%A2
#9
A Al-Attar, M Back, J Sebastian
A 73-year-old woman underwent an awake craniotomy for the resection of a supratentorial brain tumour. We provided sedation for the surgery using a dexmedetomidine target controlled infusion using the Dyck pharmacokinetic model. Using a target controlled infusion allowed more rapid titration to the desired plasma level compared with a manual infusion, without any unexpected cardiovascular, respiratory or other complications. Rapid titration of sedation during awake craniotomy is desirable, allowing deeper sedation during stimulating parts of the surgery, followed by lighter sedation - or absence of sedation - during cortical mapping...
2024: Anaesthesia reports
https://read.qxmd.com/read/38464705/preliminary-experience-with-remimazolam-for-procedural-sedation-and-as-an-adjunct-to-general-anesthesia-during-diagnostic-and-interventional-cardiac-procedures
#10
JOURNAL ARTICLE
Holly Gillis, Christopher McKee, Kristin Chenault, Marco Corridore, Joseph D Tobias
BACKGROUND: Remimazolam is a benzodiazepine which, like midazolam, has sedative, anxiolytic, and amnestic properties. Ester metabolism results in a half-life of 5 - 10 min, a limited context sensitive half-life, and rapid recovery when the infusion is discontinued. METHODS: Following the Institutional Review Board (IRB) approval, we performed a retrospective chart review of patients who received remimazolam in the cardiac catheterization, cardiac magnetic resonance imaging (MRI), and electrophysiology suites...
February 2024: Cardiology Research
https://read.qxmd.com/read/38464076/cmpl-based-purification-and-depletion-of-human-hematopoietic-stem-cells-implications-for-pre-transplant-conditioning
#11
Daisuke Araki, Sogun Hong, Nathaniel Linde, Bryan Fisk, Neelam Redekar, Christi Salisbury-Ruf, Allen Krouse, Theresa Engels, Justin Golomb, Pradeep Dagur, Diogo M Magnani, Zhirui Wang, Andre Larochelle
The transplantation of gene-modified autologous hematopoietic stem and progenitor cells (HSPCs) offers a promising therapeutic approach for hematological and immunological disorders. However, this strategy is often limited by the toxicities associated with traditional conditioning regimens. Antibody-based conditioning strategies targeting cKIT and CD45 antigens have shown potential in mitigating these toxicities, but their long-term safety and efficacy in clinical settings require further validation. In this study, we investigate the thrombopoietin (TPO) receptor, cMPL, as a novel target for conditioning protocols...
February 28, 2024: bioRxiv
https://read.qxmd.com/read/38457548/hantavirus-infection-related-acute-inflammatory-demyelinative-polyradiculoneuropathy-a-case-report-and-literature-review
#12
REVIEW
Ying Zhou, Jun Yang, Hong Hai, Jun Dong, Ying Wen
RATIONALE: Hemorrhagic fever with renal syndrome (HFRS) is a common infectious disease in China. As a complication of post-Hantavirus infection, Guillain-Barre syndrome (GBS) was rarely previously reported. Here, we described a case of acute inflammatory demyelinative polyradiculoneuropathy secondary to Hantavirus infection in spring of 2023. We also made a summary of the clinical features from previous reported cases. PATIENT CONCERNS: A young male patient complained a fever with headache, who was subsequently diagnosed with HFRS with positive serum Hantavirus antibody IgM...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38447697/examination-of-monosodium-urate-crystal-depletion-and-bone-erosion-remodeling-during-pegloticase-treatment-in-patients-with-uncontrolled-gout-exploratory-dual-energy-computed-tomography-findings-from-mirror-rct
#13
JOURNAL ARTICLE
Nicola Dalbeth, John Botson, Kenneth Saag, Ada Kumar, Lissa Padnick-Silver, Brian LaMoreaux, Fabio Becce
OBJECTIVE: Monosodium-urate (MSU) crystal deposits can be visualized and quantified with dual-energy CT (DECT). Pegloticase lowers serum urate (SU) in uncontrolled gout patients, with methotrexate (MTX) co-therapy recommended to increase SU-lowering response rate and decrease infusion reaction risk. The literature on serial DECT-imaging during pegloticase+MTX co-therapy is sparse, with only 2 prior cases of rapid MSU deposition depletion with subsequent bone-erosion remodeling reported from a small open-label trial...
March 4, 2024: Joint, Bone, Spine: Revue du Rhumatisme
https://read.qxmd.com/read/38447139/underwater-bubble-manipulation-on-surfaces-with-patterned-regions-with-infused-lubricants
#14
JOURNAL ARTICLE
Shiping He, Zijie Li, Anhui Yu, Zhiguang Guo
The flexible manipulation of underwater gas bubbles on solid substrates has attracted considerable research interest from scientists in the fields of water electrolysis, bubble microreactions, drug delivery, and heat transfer. Inspired by the oxygen-binding mechanisms of aquatic organisms, scientists have designed a series of interfacial materials for use in collecting gases, detecting and grading bubbles, and conducting microbubble reactions. Aerophilic surfaces are commonly used in underwater bubble manipulation platforms due to their excellent gas-trapping properties...
March 6, 2024: ACS Applied Materials & Interfaces
https://read.qxmd.com/read/38444477/the-feasibility-of-dexmedetomidine-led-anesthesia-maintenance-strategy-during-major-abdominal-surgery
#15
JOURNAL ARTICLE
Cheng Ni, Wenjie Xu, Bing Mu, Hongyi Li, Jiao Geng, Yinyin Qu, Yi Tian, Jie Yu, Naiyuan Tian, Xiaoxiao Wang, Chan Chen, Xu Jin, Hui Zheng
BACKGROUND: Dexmedetomidine is known for its selective action on α2-adrenoceptor sites and is recognized for its neuroprotective capabilities. It can improve postoperative cognitive function. Commonly used anesthetics, such as sevoflurane and propofol, have been reported to affect postoperative cognitive function. Therefore, it could be valuable to explore dexmedetomidine-led anesthesia strategy. This study was designed to assess the performance, safety, and effective infusion rate in anesthesia maintenance, to explore a feasible dexmedetomidine-led anesthesia maintenance protocol, and to provide a foundation for potential combined anesthesia...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38444298/fulminant-type%C3%A2-1-diabetes-an-underrecognized-and-unique-subtype-of-type%C3%A2-1-diabetes-a-case-series-from-singapore
#16
Sarah Ying Tse Tan, Suresh Rama Chandran, Jielin Yew, Andy Jun-Wei Wong, Daphne Su-Lyn Gardner
Fulminant type 1 diabetes (FT1D) is a unique subtype of type 1 diabetes, characterized by acute absolute insulin deficiency, severe ketosis, and increased risk of hypoglycemia, glycemic variability and microvascular complications. Seven people with FT1D were identified from two tertiary centers in Singapore. Six were Chinese, the mean age was 35 years and all were lean (mean body mass index 20.3 kg/m2 ). All presented with diabetes ketosis or ketoacidosis and low C-peptide. All but one had low glutamic acid decarboxylase antibodies...
March 5, 2024: Journal of Diabetes Investigation
https://read.qxmd.com/read/38440104/patient-reported-outcomes-on-sleep-quality-and-circadian-rhythm-during-treatment-with-intravenous-ketamine-for-treatment-resistant-depression
#17
JOURNAL ARTICLE
Raymond Yan, Tyler Marshall, Atul Khullar, Travis Nagle, Jake Knowles, Mai Malkin, Brittany Chubbs, Jennifer Swainson
BACKGROUND: Intravenous (IV) ketamine is a rapid acting antidepressant used primarily for treatment-resistant depression (TRD). It has been suggested that IV ketamine's rapid antidepressant effects may be partially mediated via improved sleep and changes to the circadian rhythm. OBJECTIVES: This study explores IV ketamine's association with changes in patient-reported sleep quality and circadian rhythm in an adult population with TRD. METHODS: Adult patients (18-64 years) with TRD scheduled for IV ketamine treatment were recruited to complete patient rated outcomes measures on sleep quality using the Pittsburgh Sleep Quality Index (PSQI) and circadian rhythm using the Morningness-Eveningness Questionnaire (MEQ)...
2024: Therapeutic Advances in Psychopharmacology
https://read.qxmd.com/read/38436495/reversal-of-opioid-induced-respiratory-depression-in-healthy-volunteers-comparison-of-intranasal-nalmefene-and-intranasal-naloxone
#18
JOURNAL ARTICLE
Mark Ellison, Emily Hutton, Lynn Webster, Phil Skolnick
An open-label, randomized, crossover study in healthy volunteers compared the reversal of remifentanil-induced respiratory depression by intranasal (IN) naloxone hydrochloride (4 mg) to IN nalmefene (2.7 mg) (NCT04828005). Subjects were administered a hypercapnic gas mixture which produces an elevation in minute ventilation (MV), a result of the ventilatory response to hypercapnia. Subjects breathed a hypercapnic gas mixture through a tight-fitting mask for an initial period of 46 min prior to a series of mask "holidays" introduced to reduce subject discomfort and encourage study completion...
March 4, 2024: Journal of Clinical Pharmacology
https://read.qxmd.com/read/38428223/g-protein-coupled-estrogen-receptor-gper-in-the-dorsal-hippocampus-regulates-memory-consolidation-in-gonadectomized-male-mice-likely-via-different-signaling-mechanisms-than-in-female-mice
#19
JOURNAL ARTICLE
Gustavo D B Machado, Alexis L Schnitzler, Aaron W Fleischer, Sarah B Beamish, Karyn M Frick
Studies in ovariectomized (OVX) female rodents suggest that G protein-coupled estrogen receptor (GPER) is a key regulator of memory, yet little is known about its importance to memory in males or the cellular mechanisms underlying its mnemonic effects in either sex. In OVX mice, bilateral infusion of the GPER agonist G-1 into the dorsal hippocampus (DH) enhances object recognition and spatial memory consolidation in a manner dependent on rapid activation of c-Jun N-terminal kinase (JNK) signaling, cofilin phosphorylation, and actin polymerization in the DH...
February 29, 2024: Hormones and Behavior
https://read.qxmd.com/read/38424011/rapid-critical-care-training-for-nurses-deployed-to-intensive-care-units-during-the-covid-19-surge
#20
JOURNAL ARTICLE
Susan I Liu, Andrew Greenway, Kathryn Sobocinski, Anjile An, Robert J Winchell, Philip S Barie
BACKGROUND: During the first COVID-19 pandemic wave, non-intensive care unit (non-ICU) nurses were deployed to temporary ICUs to provide critical care for the patient surge. A rapid critical care training program was designed to prepare them to care for patients in either temporary or permanent ICUs. OBJECTIVE: To evaluate the effectiveness of this training program in preparing non-ICU nurses to provide critical care for COVID-19 patients in temporary ICUs. METHODS: A survey was used to evaluate the impact of rapid critical care training on nurses' critical care skills and compare the experiences of nurses deployed to temporary versus permanent ICUs...
March 1, 2024: American Journal of Critical Care
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