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https://www.readbyqxmd.com/read/29772733/effect-of-babassu-natural-filler-on-pbat-phb-biodegradable-blends-an-investigation-of-thermal-mechanical-and-morphological-behavior
#1
Vinicius C Beber, Silvio de Barros, Mariana D Banea, Markus Brede, Laura H de Carvalho, Ron Hoffmann, Anna Raffaela M Costa, Elieber B Bezerra, Ingridy D S Silva, Katharina Haag, Katharina Koschek, Renate M R Wellen
Blending of biodegradable polymers in combination with low-price organic fillers has proven to be a suitable approach to produce cost-effective composites in order to address pollution issues and develop products with superior mechanical properties. In the present research work PBAT/PHB/Babassu composites with 25, 50, and 75% of each polymer and 20% of Babassu were produced by melting extrusion. Their thermal, mechanical, and morphological behavior was investigated by differential scanning calorimetry (DSC), tensile testing, and scanning electron microscopy (SEM)...
May 16, 2018: Materials
https://www.readbyqxmd.com/read/29751644/protective-effects-of-selected-botanical-agents-on-bone
#2
REVIEW
James Jam Jolly, Kok-Yong Chin, Ekram Alias, Kien Hui Chua, Ima Nirwana Soelaiman
Osteoporosis is a serious health problem affecting more than 200 million elderly people worldwide. The early symptoms of this disease are hardly detectable. It causes progressive bone loss, which ultimately renders the patients susceptible to fractures. Osteoporosis must be prevented because the associated fragility fractures result in high morbidity, mortality, and healthcare costs. Many plants used in herbal medicine contain bioactive compounds possessing skeletal protective effects. This paper explores the anti-osteoporotic properties of selected herbal plants, including their actions on osteoblasts (bone forming cells), osteoclasts (bone resorbing cells), and bone remodelling...
May 11, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29727687/variants-in-exosc9-disrupt-the-rna-exosome-and-result-in-cerebellar-atrophy-with-spinal-motor-neuronopathy
#3
David T Burns, Sandra Donkervoort, Juliane S Müller, Ellen Knierim, Diana Bharucha-Goebel, Eissa Ali Faqeih, Stephanie K Bell, Abdullah Y AlFaifi, Dorota Monies, Francisca Millan, Kyle Retterer, Sarah Dyack, Sara MacKay, Susanne Morales-Gonzalez, Michele Giunta, Benjamin Munro, Gavin Hudson, Mena Scavina, Laura Baker, Tara C Massini, Monkol Lek, Ying Hu, Daniel Ezzo, Fowzan S AlKuraya, Peter B Kang, Helen Griffin, A Reghan Foley, Markus Schuelke, Rita Horvath, Carsten G Bönnemann
The exosome is a conserved multi-protein complex that is essential for correct RNA processing. Recessive variants in exosome components EXOSC3, EXOSC8, and RBM7 cause various constellations of pontocerebellar hypoplasia (PCH), spinal muscular atrophy (SMA), and central nervous system demyelination. Here, we report on four unrelated affected individuals with recessive variants in EXOSC9 and the effect of the variants on the function of the RNA exosome in vitro in affected individuals' fibroblasts and skeletal muscle and in vivo in zebrafish...
May 3, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29724549/the-antibacterial-cytotoxic-and-flexural-properties-of-a-composite-resin-containing-a-quaternary-ammonium-monomer
#4
Qiting Huang, Shuheng Huang, Xiaoxu Liang, Wei Qin, Fang Liu, Zhengmei Lin, Jingwei He
STATEMENT OF PROBLEM: The use of composite resin to restore teeth has increased substantially during the last decades. However, secondary caries and the fracture of restorations are the leading reasons for clinical restoration failure. Mechanically strong composite resins with caries-inhibition capabilities are needed. Although antibacterial dimethacrylate quaternary ammonium monomers have been synthesized, composite resin containing dimethacrylate quaternary ammonium monomers and glass fillers has rarely been reported...
April 30, 2018: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/29713797/whole-egg-consumption-and-cortical-bone-in-healthy-children
#5
L M Coheley, J M Kindler, E M Laing, A Oshri, K M Hill Gallant, S J Warden, M Peacock, C M Weaver, R D Lewis
Eggs contain bioactive compounds thought to benefit pediatric bone. This cross-sectional study shows a positive link between childhood egg intake and radius cortical bone. If randomized trials confirm our findings, incorporating eggs into children's diets could have a significant impact in preventing childhood fractures and reducing the risk of osteoporosis. INTRODUCTION: This study examined the relationships between egg consumption and cortical bone in children. METHODS: The cross-sectional study design included 294 9-13-year-old black and white males and females...
April 30, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29704955/comparison-of-plate-osteosynthesis-versus-non-operative-management-for-mid-shaft-clavicle-fractures-a-prospective-study
#6
Akshay Bhardwaj, Gaurav Sharma, Ashok Patil, Vaijnath Rahate
INTRODUCTION: Treatment for mid-shaft clavicle fractures has recently seen a paradigm shift towards surgical management. The aim of the study was to compare clinical and functional outcome between plate osteosynthesis and conservative line of management in middle-third clavicle fractures. MATERIAL AND METHODS: A prospective randomized study was conducted on 69 patients with closed displaced clavicle fractures between May 2014 and May 2016. Patients with medial or lateral third clavicle fractures, polytrauma and compound fractures were excluded from the study...
April 17, 2018: Injury
https://www.readbyqxmd.com/read/29698291/csa-90-promotes-bone-formation-and-mitigates-methicillin-resistant-staphylococcus-aureus-infection-in-a-rat-open-fracture-model
#7
Rebecca Mills, Tegan L Cheng, Kathy Mikulec, Lauren Peacock, David Isaacs, Carl Genberg, Paul B Savage, David G Little, Aaron Schindeler
BACKGROUND: Infection of open fractures remains a significant cause of morbidity and mortality to patients worldwide. Early administration of prophylactic antibiotics is known to improve outcomes; however, increasing concern regarding antimicrobial resistance makes finding new compounds for use in such cases a pressing area for further research. CSA-90, a synthetic peptidomimetic compound, has previously demonstrated promising antimicrobial action against Staphylococcus aureus in rat open fractures...
April 24, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29692940/lymph-drainage-of-posttraumatic-edema-of-lower-limbs
#8
Ana Carolina Pereira de Godoy, Rodrigo Ocampos Troitino, Maria de Fátima Guerreiro Godoy, José Maria Pereira de Godoy
Objective: The present study was aimed at evaluating the use of mechanical and manual lymphatic therapy as a treatment for lymphedema resulting from orthopedic surgery that became painful after an episode of erysipelas. Case Report: A 70-year-old male patient suffered direct trauma resulting in a compound fracture of the tibia and fibula of the left leg. He was treated with an external fixator for four months followed by plaster cast immobilization for three weeks...
2018: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29682010/craniofacial-trauma-in-pediatric-patients-following-winnowing-blade-injury-review-of-literature
#9
REVIEW
Harsha Huliyappa, Balakrishna Ojha, Anil Chandra, Sunil Kumar Singh, Chhitij Srivastava
In developing countries, during the harvest season, winnower blade injuries occur very frequently in children and results in lifelong disability. Nine children were managed during 1 month, all resulting due to winnower blade induced craniofacial trauma. PubMed search for "fan blade injury" showed two case series and three case reports. In our study, 88% had compound depressed fracture; brain matter leak in 56%, cerebrospinal fluid (CSF) leak alone in 22%. 66.7% had injury involving the frontal bone...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29681283/matrix-effect-free-determination-of-btex-in-variable-soil-compositions-using-room-temperature-ionic-liquid-co-solvents-in-static-headspace-gas-chromatography-mass-spectrometry
#10
Emmanuel Varona-Torres, Doug D Carlton, Zacariah L Hildenbrand, Kevin A Schug
Concerns about the environmental impact of shale energy exploration (i.e., hydraulic fracturing and other well stimulation techniques) have risen due to its rapid expansion in the United States and other countries. Soils in shale basins engaged in unconventional oil and gas development can become contaminated by volatile organic compounds (VOCs), such as benzene, toluene, ethylbenzene, and xylenes (BTEX) through mishandling of chemical additives, products, and/or waste fluids. In this study, room temperature ionic liquids (RTILs) were evaluated as solvents in an effort to increase sensitivity and to reduce and normalize matrix effects associated with varying soil compositions during analysis...
August 27, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29679836/physical-immobility-as-a-sensitive-indicator-of-hydraulic-fracturing-fluid-toxicity-towards-daphnia-magna
#11
Tamzin A Blewett, Perrine L M Delompré, Chris N Glover, Greg G Goss
The process of extracting hydrocarbon resources by hydraulic fracturing is an increasingly utilised technique worldwide, resulting in an effluent called flowback and produced water (FPW). This effluent is a complex mixture of salts, metals and organic compounds, and has been shown to be highly toxic to aquatic biota, an effect attributed mainly to its salt and organic components. However, in the current study we show that the water flea, Daphnia magna, is physically impaired by, and rendered immobile at the surface of, test waters containing FPW...
April 18, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29679717/stat-3-regulation-of-cxcr4-is-necessary-for-the-prenylflavonoid-icaritin-to-enhance-mesenchymal-stem-cell-proliferation-migration-and-osteogenic-differentiation
#12
R Z L Lim, L Li, E L Yong, N Chew
Mesenchymal stem cell (MSC) dysfunction has been implicated in the pathogenesis of osteoporosis. MSCs derived from osteoporotic subjects demonstrate significant impairment in proliferation, adhesion and chemotaxis, and osteogenic differentiation, leading to reduced functional bone-forming osteoblasts and ultimately nett bone loss and osteoporosis. Epimedium herbs and its active compound Icaritin (ICT) have been used in Chinese ethnopharmacology for the treatment of metabolic bone diseases. Using an in-vitro cell culture model, we investigated the benefits of ICT treatment in enhancing MSC proliferation, migration and osteogenic differentiation, and provide novel data to describe its mechanism of action...
April 18, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29678628/poria-cocos-polysaccharide-attenuates-rankl-induced-osteoclastogenesis-by-suppressing-nfatc1-activity-and-phosphorylation-of-erk-and-stat3
#13
Dezhi Song, Zhen Cao, Jennifer Tickner, Heng Qiu, Chao Wang, Kai Chen, Ziyi Wang, Chunyu Guo, Shiwu Dong, Jiake Xu
Pathological fractures caused by osteolytic lesions seriously threaten the health of patients. Osteoclasts play important roles in bone resorption whose hyperfunction are closely related to osteolytic lesions. Studies on osteoclast differentiation and function assist in the prevention of excessive bone loss associated diseases. We screened a variety of natural compounds with anti-inflammatory effect and found that poria cocos polysaccharide (PCP) inhibited RANKL-induced osteoclast formation and bone resorption via TRAcP staining, immunofluorescence, RT-PCR and western blot...
April 17, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29657482/functional-and-radiological-outcome-in-management-of-compound-tibia-diaphyseal-fracture-with-ao-monolateral-fixator-versus-limb-reconstruction-system
#14
Hitesh J Mangukiya, Neetin P Mahajan, Eknath D Pawar, Aakash Mane, Jitsen Manna
Introduction: Tibia being the most common fractured long bone represents 36.7% of all long bone fractures in adults with open fracture comprises 23.5% of all tibial shaft fracture. The lack of the muscular covering over anteromedial aspect of the tibia and poor blood supply predispose open tibial fractures to a 10-20 fold increased risk of developing infection than open fracture in any other anatomical areas and a nonunion rate as high as 28% has been reported in the literature. Methods: We did a prospective study at our institute from 2014-2016 comprising 40 patients with compound tibia diaphyseal fracture managed with AO monolateral external fixator (Group 1) (n = 20) and Limb reconstruction system (Group 2) (n = 20) as primary and definitive tool...
March 2018: Journal of Orthopaedics
https://www.readbyqxmd.com/read/29649480/high-glucose-downregulates-the-effects-of-autophagy-on-osteoclastogenesis-via-the-ampk-mtor-ulk1-pathway
#15
Zhen-Yu Cai, Bo Yang, Ying-Xu Shi, Wei-Lin Zhang, Fei Liu, Wei Zhao, Mao-Wei Yang
Diabetes is a chronic disease that disrupts the balance between bone formation and bone desorption, which can lead to osteoporosis, increasing the risk of fracture. However, compared with osteoblasts, the biological effects of hyperglycemia on osteoclastogenesis remain to be elucidated. Therefore, we investigated the impact of glucose at different concentrations (5.5, 10.5, 15.5, 20.5, 25.5, and 30.5 mM) on osteoclastogenesis using RAW264.7 cells. Cell proliferation was measured with the cell counting kit-8 assay, and osteoclastogenesis was detected with tartrate-resistant acid phosphatase staining and bone resorption assays, as well as protein cathepsin K expression...
April 9, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29604389/effects-of-sodium-glucose-cotransporter-2-inhibitors-on-cardiovascular-disease-death-and-safety-outcomes-in-type-2-diabetes-a-systematic-review
#16
REVIEW
Karin Rådholm, Jason Hy Wu, Muh Geot Wong, Celine Foote, Gregory Fulcher, Kenneth W Mahaffey, Vlado Perkovic, Bruce Neal
AIM: Sodium glucose co-transporter 2 (SGLT2) inhibitors appear to protect against increased risks of cardiovascular and kidney disease in patients with type 2 diabetes but also cause some harms. Whether effects are comparable across drug class or specific to individual compounds is unclear. This meta-analysis assessed the class and individual compound effects of SGLT2 inhibition versus control on cardiovascular events, death, kidney disease and safety outcomes in patients with type 2 diabetes...
March 28, 2018: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/29588245/predicting-dural-tear-in-compound-depressed-skull-fractures-a-prospective-multi-center-correlational-study
#17
Shemsedin Musefa Salia, Hagos Biluts Mersha, Abenezer Tirsit Aklilu, Abate Sahlu Baleh, Morten Lund-Johansen
BACKGROUND: Compound depressed skull fractures (DSF) are neurosurgical emergencies. Pre-operative knowledge of dural status is indispensable for treatment decision. This study aims to determine predictors of dural tear from clinical and imaging characteristics in patients with compound DSF. PATIENTS AND METHODS: The authors conducted a prospective, multi-center correlational study in neurosurgical hospitals in Addis Ababa, Ethiopia. Patients (n=128) operated from January 1 to October 31, 2016 were included...
March 24, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29578106/two-team-management-of-vascular-injuries-concomitant-with-osteo-articular-injuries-in-36-patients-over-six-years
#18
B Leclerc, E Boyer, G Menu, G Leclerc, P Sergent, E Ducroux, L Salomon Du Mont, P Garbuio, S Rinckenbach, L Obert
BACKGROUND: Patients with both vascular and osteoarticular injuries require multidisciplinary management. Vascular injuries may be function- and/or life-threatening. The lower limbs are predominantly affected. Traffic, domestic, and work-related accidents contribute most of the cases. The primary objective of this study was to describe the management of patients with concomitant vascular and osteo-articular injuries, with special attention to the rates of amputation and fasciotomy. The secondary objective was to suggest a management sequence to optimise our surgical practice...
March 22, 2018: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/29558955/exploring-the-endocrine-activity-of-air-pollutants-associated-with-unconventional-oil-and-gas-extraction
#19
REVIEW
Ashley L Bolden, Kim Schultz, Katherine E Pelch, Carol F Kwiatkowski
BACKGROUND: In the last decade unconventional oil and gas (UOG) extraction has rapidly proliferated throughout the United States (US) and the world. This occurred largely because of the development of directional drilling and hydraulic fracturing which allows access to fossil fuels from geologic formations that were previously not cost effective to pursue. This process is known to use greater than 1,000 chemicals such as solvents, surfactants, detergents, and biocides. In addition, a complex mixture of chemicals, including heavy metals, naturally-occurring radioactive chemicals, and organic compounds are released from the formations and can enter air and water...
March 21, 2018: Environmental Health: a Global Access Science Source
https://www.readbyqxmd.com/read/29558920/pre-operative-radiographic-findings-predicting-concomitant-posterior-malleolar-fractures-in-tibial-shaft-fractures-a-comparative-retrospective-study
#20
Zhipeng Huang, Yuan Liu, Wenjun Xie, Xiang Li, Xiaodong Qin, Jun Hu
BACKGROUND: A concomitant tibial shaft and posterior malleolar fracture is a type of regular compound fracture. The associated posterior malleolar fractures are mostly occult fractures, which often do not show a fracture line on ordinary films, and thus lead to a high rate of misdiagnosis. The aim of the present study was to investigate factors helpful for the pre-operative detection of concomitant posterior ankle fractures using the ipsilateral radiographic tibia and fibula shaft fracture characteristics...
March 20, 2018: BMC Musculoskeletal Disorders
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