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https://www.readbyqxmd.com/read/29318649/treatment-related-changes-in-bone-turnover-and-fracture-risk-reduction-in-clinical-trials-of-anti-resorptive-drugs-a-meta-regression
#1
Douglas C Bauer, Dennis M Black, Mary L Bouxsein, Li-Yung Lui, Jane A Cauley, Anne E de Papp, Andreas Grauer, Sundeep Khosla, Charles E McCulloch, Richard Eastell
Few pooled analyses of antiresorptive (AR) treatment trials relate short-term changes in bone turnover markers (BTMs) to subsequent fracture reduction. Such information would be useful to assess new ARs or novel dosing regimens. In the Foundation for the National Institutes of Health (FNIH) Bone Quality project, we analyzed individual-level data from 28,000 participants enrolled in 11 bisphosphonate (BP) and three selective estrogen receptor modulator (SERM) placebo-controlled fracture endpoint trials. Using BTM results for two bone formation markers (bone-specific alkaline phosphatase [bone ALP] and pro-collagen I N-propeptide [PINP]) and two bone resorption markers (N-terminal and C-terminal telopeptide of type I collagen) and incident fracture outcome data, we performed a meta-regression relating the mean net effect of treatment on change in bone turnover (active minus placebo % difference after 3 to 12 months) to the log of study-wide fracture risk reduction, and used linear regression to plot the best fitting line...
January 10, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29316625/interfacial-reaction-and-imc-growth-of-an-ultrasonically-soldered-cu-sac305-cu-structure-during-isothermal-aging
#2
Yulong Li, Weifeng Long, Xiaowu Hu, Yanshu Fu
In order to accelerate the growth of interfacial intermetallic compound (IMC) layers in a soldering structure, Cu/SAC305/Cu was first ultrasonically spot soldered and then subjected to isothermal aging. Relatively short vibration times, i.e., 400 ms and 800 ms, were used for the ultrasonic soldering. The isothermal aging was conducted at 150 °C for 0, 120, 240, and 360 h. The evolution of microstructure, the IMC layer growth mechanism during aging, and the shear strength of the joints after aging were systemically investigated...
January 6, 2018: Materials
https://www.readbyqxmd.com/read/29313541/exploring-the-hydraulic-fracturing-parameter-space-a-novel-high-pressure-high-throughput-reactor-system-for-investigating-subsurface-chemical-transformations
#3
Andrew J Sumner, Desiree L Plata
Hydraulic fracturing coupled with horizontal drilling (HDHF) involves the deep-well injection of a fracturing fluid composed of diverse and numerous chemical additives designed to facilitate the release and collection of natural gas from shale plays. Analyses of flowback wastewaters have revealed organic contamination from both geogenic and anthropogenic sources. The additional detections of undisclosed halogenated chemicals suggest unintended in situ transformation of reactive additives, but the formation pathways for these are unclear in subsurface brines...
January 9, 2018: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/29303857/reconstruction-of-a-compound-oromandibular-defect-by-means-of-chimeric-scapular-parascapular-free-flap-assisted-by-virtual-surgical-planning
#4
Josué Hernando, Antonio Aguilar-Salvatierra, Ignacio Osoitz Leizaola-Cardesa, Juan Antonio Rad, Amaya Vicuña, Rafael Gómez, Javier Martín, Gerardo Gómez-Moreno
BACKGROUND: Reconstruction of an oromandibular defect presents a considerable surgical challenge. But since the advent of microvascularized free flap reconstructive surgery, outcomes have improved significantly so that today almost any defect may be reconstructed. Recently, virtual surgical planning has reduced surgical time, the morbidity associated with surgery, and surgical precision. OBJECTIVE: This article reports a complex patient with a composite oromandibular defect...
January 4, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29280081/how-to-adapt-chemical-risk-assessment-for-unconventional-hydrocarbon-extraction-related-to-the-water-system
#5
Ann-Hélène Faber, Mark Annevelink, Herman Kasper Gilissen, Paul Schot, Marleen van Rijswick, Pim de Voogt, Annemarie van Wezel
We identify uncertainties and knowledge gaps of chemical risk assessment related to unconventional drillings and propose adaptations. We discuss how chemical risk assessment in the context of unconventional oil and gas (UO&G) activities differs from conventional chemical risk assessment and the implications for existing legislation. A UO&G suspect list of 1,386 chemicals that might be expected in the UO&G water samples was prepared which can be used for LC-HRMS suspect screening. We actualize information on reported concentrations in UO&G-related water...
December 27, 2017: Reviews of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/29278266/regional-nerve-blockade-for-early-analgesic-management-of-elderly-patients-with-hip-fracture-a-narrative-review
#6
REVIEW
A Scurrah, C T Shiner, J A Stevens, S G Faux
Elderly patients with hip fracture experience high morbidity and mortality, and are often undertreated for pain. Acute pain management in the elderly is challenging, with physiological frailty, medical comorbidities and cognitive impairment commonly compounding pain assessment and treatment. Guidelines outlining current best practice for acute pain management in the elderly now exist, but evidence suggests that practice remains variable and there continues to be scope for improvement. We conducted a narrative review of the literature to examine the challenges of acute pain management in the elderly, and to evaluate evidence for the role of regional nerve blocks for acute pain associated with hip fracture in the elderly...
December 26, 2017: Anaesthesia
https://www.readbyqxmd.com/read/29274971/sensory-and-chemical-properties-of-gouda-cheese
#7
Y Jo, D M Benoist, A Ameerally, M A Drake
Gouda cheese is a washed-curd cheese that is traditionally produced from bovine milk and brined before ripening for 1 to 20 mo. In response to domestic and international demand, US production of Gouda cheese has more than doubled in recent years. An understanding of the chemical and sensory properties of Gouda cheese can help manufacturers create desirable products. The objective of this study was to determine the chemical and sensory properties of Gouda cheeses. Commercial Gouda cheeses (n = 36; 3 mo to 5 yr; domestic and international) were obtained in duplicate lots...
December 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/29259963/comparison-of-bone-mineral-density-and-appendicular-lean-body-mass-between-osteoporotic-distal-radius-fracture-and-degenerative-rotator-cuff-tear-in-women-patients
#8
Jun-Ku Lee, Byung-Ho Yoon, Kyunghun Jung, Gotak Kim, Soo-Hong Han
Background: Authors assessed lean body mass (fat free tissue), upper and lower, and bone mineral density (BMD) in patients of osteoporotic bone distal radius fracture (DRF) and degenerative rotator cuff tear (RCT) patients of shoulder. We predict inferior muscle mass and osteoporosis are more frequent in DRF group than RCT group. Methods: Between January 2016 and June 2017, overall 38 of DRF and 30 of RCT were eligible for this retrospective comparison study after excluding of patients with compounding factors...
November 2017: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/29242802/resistant-non-union-of-humerus-after-intramedullary-nailing-treated-with-locking-compression-plate-with-bone-grafting-with-nail-in-situ-and-shoulder-spica-a-case-report
#9
Jagdeep Singh, Anoop Kalia, Kavin Khatri, Anshul Dahuja
Introduction: Humerus non-union is a challenging situation for the surgeon and devastating and morbid situation for the patient. Surgical approach to the humerus is demanding because of the complex neurovascular anatomy and especially when previous surgeries have been attempted. Case Report: We report a case of a young adult male who sustained a compound fracture of humerus shaft treated with intramedullary nailing followed by subsequent bone grafting and eventually landed up in non-union and was treated at our center by locking compression plate application with nail in situ with iliac crest autogenous bone graft followed by shoulder spica application...
September 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29235279/-advance-of-a-representative-traditional-tibetan-medicine-meconopsis-horridula-on-its-phytochemical-and-pharmacological-aspects
#10
REVIEW
Feng Zhao, He-Xin-Ge Zhang, Rui-Feng Bai, Bing-Zhao Tu, Xiao-Li Gao, Peng-Fei Tu, Xing-Yun Chai
Meconopsis horridula is one of alpine plants belonging to family Papaveraceae, mainly distributed in Himalaya Range area. M. horridula is a rare alpine flower, and is a kind of traditional Tibetan medicine, which has been included in more than 40 compound formulae, having efficacies of clearing away heat and alleviating pain, activating blood circulation to remove stasis, traditionally used for the treatment of fractures, injuries, and chest and back pains. Modern research shows that the whole plant of M. horridula contains alkaloids, flavonoids, and terpenes, and its pharmacological activities including antitumor, antivirus and myocardial protection etc...
October 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29200490/management-of-nail-bed-injuries-associated-with-fingertip-injuries
#11
Alexander George, Reena Alexander, C Manju
Background: Management of nail injuries can often be a challenging experience, especially in presence of complex fingertips' injuries that include soft tissue loss and distal phalanx injury. Most studies found in the literature focus on individual injuries and describe methods to tackle those injuries, notwithstanding the fact that the nail, nailbed, distal phalanx, soft tissue and skin of the finger tip form a complex and often more than one element of this complex is injured. This retrospective study therefore focuses on the management of nail bed injuries as a part of the complex finger tip injury and outlines the surgical principles and techniques that were used in their management...
November 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/29198835/cinnamomum-burmanini-blume-increases-bone-turnover-marker-and-induces-tibia-s-granule-formation-in-ovariectomized-rats
#12
Nia Kania, Wahyu Widowati, Firli Rahmah Primula Dewi, Antonius Christianto, Bambang Setiawan, Nicolaas Budhiparama, Zairin Noor
BACKGROUND: Bone fragility and an increase in susceptibility to fracture osteoporosis is characterized by a reduction in bone mass and the micro-architectural deterioration of bone tissue. There is no previous study regarding the effect of Cinnamomum burmanini Blume on osteoporosis. OBJECTIVE: This study was aimed to investigate the effect of C. burmanini Blume on bone turnover marker, mineral elements, and mesostructure of ovariectomized rats. MATERIALS AND METHODS: Thirty female Wistar rats were randomly divided into five groups, which included a control group (sham surgery), ovariectomy group (OVX), and ovariectomy groups in the presence of ethanolic extract of C...
November 30, 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29194609/using-the-connectivity-map-to-discover-compounds-influencing-human-osteoblast-differentiation
#13
A M Brum, J van de Peppel, L Nguyen, A Aliev, M Schreuders-Koedam, T V Gajadien, C S van der Leije, A van Kerkwijk, M Eijken, J P T M van Leeuwen, B C J van der Eerden
Osteoporosis is a common skeletal disorder characterized by low bone mass leading to increased bone fragility and fracture susceptibility. Identification of factors influencing osteoblast differentiation and bone formation is very important. Previously, we identified parbendazole to be a novel compound that stimulates osteogenic differentiation of human mesenchymal stromal cells (hMSCs), using gene expression profiling and bioinformatic analyses, including the Connectivity Map (CMap), as an in-silico approach...
December 1, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29188647/-experimental-study-on-accelerated-healing-of-jaw-fracture-using-gelatin-sponge-compound-growth-factor
#14
Tang Yanfeng, Chen Jianlin, Zhou Yunbiao
OBJECTIVE: To explore the role and mechanism of drug delivery systems using growth factor combined with gelatin sponge on accelerating the healing of jaw fracture and to seek better treatment of accelerating the maxillofacial fracture. METHODS: About 100 μg recombinant human bone morphogenetic protein (BMP)-2 was completely dissolved in 1 mL recombinant bovine basic fibroblast growth factor (bFGF), and the solution (40 μL) was dropped in gelatin sponge (0.5 cm×0...
October 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/29178448/expanding-the-clinical-spectrum-of-phenotypes-caused-by-pathogenic-variants-in-plod2
#15
Gabriela Ferraz Leal, Gen Nishimura, Ulrika Voss, Débora Romeo Bertola, Eva Åström, Johan Svensson, Guilherme Lopes Yamamoto, Anna Hammarsjö, Eva Horemuzova, Nikos Papadiogannakis, Erik Iwarsson, Giedre Grigelioniene, Emma Tham
Osteogenesis imperfecta (OI) is a strikingly heterogeneous group of disorders with a broad range of phenotypic variations. It is also one of the differential diagnoses in bent bone dysplasias along with campomelic dysplasia and thanatophoric dysplasia and can usually be distinguished by decreased bone mineralization and bone fractures. Bent bone dyplasias also include syndromes such as kyphomelic dysplasia [MIM:211350] and mesomelic dysplasia Kozlowski-Reardon [MIM249710], both of which have been under debate regarding whether or not they are a real entity or simply a phenotypic manifestation of another dysplasia including OI...
November 27, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29146294/distinct-effects-of-interleukin-6-classic-and-trans-signaling-in-bone-fracture-healing
#16
Katja Prystaz, Kathrin Kaiser, Anna Kovtun, Melanie Haffner-Luntzer, Verena Fischer, Anna E Rapp, Astrid Liedert, Gudrun Strauss, Georg H Waetzig, Stefan Rose-John, Anita Ignatius
Bone healing is a complex process with closely linked phases of inflammation, regeneration, and remodeling. Interleukin-6 (IL-6) may crucially regulate this process; however, the underlying mechanisms are presently unclear. IL-6 signals are transmitted via the transmembrane glycoprotein 130 by two distinct mechanisms: classic signaling employing the membrane-anchored IL-6 receptor, and trans-signaling using its soluble form. Here, we investigated the hypothesis that IL-6 classic and trans-signaling have different functions during bone healing...
November 13, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/29132208/organic-chemical-characterization-and-mass-balance-of-a-hydraulically-fractured-well-from-fracturing-fluid-to-produced-water-over-405-days
#17
James S Rosenblum, E Michael Thurman, Imma Ferrer, George R Aiken, Karl G Linden
A long-term field study (405 days) of a hydraulically fractured well from the Niobrara Formation in the Denver-Julesburg Basin was completed. Characterization of organic chemicals used in hydraulic fracturing and their changes through time, from the pre-injected fracturing fluid to the produced water, was conducted. The characterization consisted of a mass balance by dissolved organic carbon (DOC), volatile organic analysis by gas chromatography/mass spectrometry, and nonvolatile organic analysis by liquid chromatography/mass spectrometry...
November 14, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/29129406/neuropeptide-y-y2-antagonist-treated-ovariectomized-mice-exhibit-greater-bone-mineral-density
#18
K L Seldeen, P G Halley, C H Volmar, M A Rodríguez, M Hernandez, M Pang, S K Carlsson, L J Suva, C Wahlestedt, B R Troen, S P Brothers
Osteoporosis, a disease characterized by progressive bone loss and increased risk of fracture, often results from menopausal loss of estrogen in women. Neuropeptide Y has been shown to negatively regulate bone formation, with amygdala specific deletion of the Y2 receptor resulting in increased bone mass in mice. In this study, ovariectomized (OVX) mice were injected once daily with JNJ-31020028, a brain penetrant Y2 receptor small molecule antagonist to determine the effects on bone formation. Antagonist treated mice had reduced weight and showed increased whole-body bone mineral density compared to vehicle-injected mice...
November 7, 2017: Neuropeptides
https://www.readbyqxmd.com/read/29126025/metallurgical-residues-reused-as-filler-after-35years-and-their-natural-weathering-implications-in-a-mountain-area
#19
Leticia Gómez-Nubla, Julene Aramendia, Silvia Fdez-Ortiz de Vallejuelo, Juan Manuel Madariaga
The natural weathering of EAF (Electric Arc Furnace) and LF (Ladle Furnace) steel slag was evaluated through changes in the mineralogical and elemental composition. For that purpose, black steel slag and mixture of black and white steel slag were collected from two forest tracks, where they had been used as filler 19 and 35years ago respectively in a protected mountain area. Primary/original and secondary/degradation compounds were identified by spectroscopic techniques (Raman Spectroscopy, X-Ray Diffraction (XRD) and Scanning Electron Microscopy/Energy Dispersive X-Ray Spectroscopy (SEM/EDS))...
November 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29122312/gestational-exposure-to-volatile-organic-compounds-vocs-in-northeastern-british-columbia-canada-a-pilot-study
#20
Élyse Caron-Beaudoin, Naomi Valter, Jonathan Chevrier, Pierre Ayotte, Katherine Frohlich, Marc-André Verner
BACKGROUND: Northeastern British Columbia (Canada) is an area of intense hydraulic fracturing for unconventional natural gas exploitation. There have been multiple reports of air and water contamination by volatile organic compounds in the vicinity of gas wells. Although these chemicals are known developmental toxicants, no biomonitoring effort has been carried out in the region. OBJECTIVE: To evaluate gestational exposure to benzene and toluene in the Peace River Valley, Northeastern British Columbia (Canada)...
January 2018: Environment International
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