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https://www.readbyqxmd.com/read/28092160/discovery-of-metabolite-biomarkers-for-acute-ischemic-stroke-progression
#1
Peifang Liu, Ruiting Li, Anton A Antonov, Lihua Wang, Wei Li, Yunfei Hua, Huimin Guo, Lijuan Wang, Peijia Liu, Lixia Chen, Yuan Tian, Fengguo Xu, Zunjian Zhang, Yulan Zhu, Yin Huang
Stroke remains a major public health problem worldwide; it causes severe disability and is associated with high mortality rates. However, early diagnosis of stroke is difficult, and no reliable biomarkers are currently established. In this study, mass spectrometry-based metabolomics was utilized to characterize the metabolic features of the serum of patients with acute ischemic stroke (AIS) to identify novel sensitive biomarkers for diagnosis and progression. First, global metabolic profiling was performed on a training set of 80 human serum samples (40 cases and 40 controls)...
January 16, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28091865/improving-the-diagnostic-workup-of-hyponatremia-in-the-setting-of-kidney-disease-a-continuing-medical-education-cme-initiative
#2
Ladan Golestaneh, Joel Neugarten, William Southern, Faraj Kargoli, Amanda Raff
PURPOSE: Hyponatremia is a common electrolyte disorder and is associated with mortality. We examined the frequency of appropriate testing in response to an episode of inpatient hyponatremia in a large urban hospital to better inform our educational intervention. We then evaluated the impact of a live CME activity with a focus on CKD- and ESRD-associated hyponatremia physiology, on diagnostic practices of audience hospitalist attendings. METHODS: We performed a retrospective database analysis of all patients admitted to Montefiore Medical Center in 2014 to examine the performance of hospital staff in response to hyponatremia across all CKD stages...
January 13, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28090499/risk-factors-associated-with-high-thyroglobulin-level-following-radioactive-iodine-ablation-measured-12-months-after-treatment-for-papillary-thyroid-carcinoma
#3
Eun Young Kim, Kee Hoon Hyun, Yong Lai Park, Chan Heun Park, Ji-Sup Yun
PURPOSE: The measurement of serum thyroglobulin (Tg) of papillary thyroid carcinoma patients, 12 months after total thyroidectomy and radioactive iodine (RAI) ablation following thyroxine hormone withdrawal (T4-off Tg) or recombinant human thyroid-stimulating hormone stimulation (rhTSH-Tg), is standard method for monitoring disease status. The aim of this study was to find predictive factors for detectable T4-off Tg during follow-up. METHODS: A retrospective review was conducted of 329 patients who underwent total thyroidectomy and RAI ablation between October 2008 and August 2012...
January 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28087305/circulating-interleukin-18-il-18-is-a-predictor-of-response-to-gemcitabine-based-chemotherapy-in-patients-with-pancreatic-adenocarcinoma
#4
Çiğdem Usul Afsar, Mehmet Karabulut, Senem Karabulut, Halil Alis, Murat Gonenc, Nergiz Dagoglu, Murat Serilmez, Faruk Tas
BACKGROUND: This study was conducted to investigate the serum levels of interleukin-18 (IL-18) in patients with pancreatic adenocarcinoma (PA) and the relationship with tumor progression and known prognostic parameters. METHODS: Thirty-three patients with PA were studied. Serum samples were obtained on first admission before any treatment. Serum IL-18 levels were analyzed using enzyme-linked immunosorbent assay (ELISA). Age- and sex-matched 30 healthy controls were included in the analysis...
January 10, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28081344/peripheral-flt-3-ligand-levels-as-a-pathobiological-parameter-duringthe-clinical-course-of-acute-myeloid-leukemia
#5
Memduh Şahin, İbrahim Celalettin Haznedaroğlu, Demircan Özbalcı
BACKGROUND/AIM: FLT-3 ligand is a growth factor affecting the hematopoietic lineage. The aim of this study was to evaluate the variability of peripheral FLT-3 ligand during the clinical course of acute myeloid leukemia (AML) patients. MATERIALS AND METHODS: Twenty-four patients were enrolled in this study in order to assess alterations in the circulating levels of FLT-3 ligand during the clinical course of AML. RESULTS: We studied the association in the diagnostic period between the FLT-3 ligand and peripheral blood cells together with serum electrolytes...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28079804/aquaporin-4-positive-neuromyelitis-optica-spectrum-disorders-secondary-to-thrombopenic-purpura-a-case-report
#6
Ying Wang, Qiaoyun Gong, Mingqin Zhu, Chao Lu, Li Sun, Jiachun Feng, Hongliang Zhang
RATIONALE: Neuromyelitis optica spectrum disorders (NMOSD) is considered as an immune-mediated disorder in the central nervous system (CNS). Numerous autoimmune diseases are frequently complicated with NMOSD and distinct clinical characteristics are noted in NMOSD patients with other autoimmune diseases. However, to our best knowledge, co-occurrence of NMOSD and thrombopenic purpura is rarely identified. PATIENT CONCERNS: We presented a rare case of a 72-year-old female with 6-year history of thrombopenic purpura, and 1-month history of blurred vision as well as chest zonethesia...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28079796/serum-microrna-panel-for-early-diagnosis-of-the-onset-of-hepatocellular-carcinoma
#7
Ying Zhang, Tao Li, Yumin Qiu, Tao Zhang, Pengbo Guo, Xiaomin Ma, Qing Wei, Lihui Han
Unique change of circulating microRNAs (miRNAs) was recognized to occur in early oncogenesis, which conferred it the potential as biomarkers for early detection of cancer. However, its diagnostic capability for hepatocellular carcinoma (HCC) has not been fully understood. In this study, microarray analysis was applied to screen the initial candidate miRNA from both the supernatants of anoikis-resistant cellular models and the sera samples of HCC patients. The selected differentially expressed miRNAs were further verified in 115 HCC patients and 40 health controls by qRT-PCR...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28079114/discovering-potential-serological-biomarker-for-chronic-hepatitis-b-virus-related-hepatocellular-carcinoma-in-chinese-population-by-mal-associated-serum-glycoproteomics-analysis
#8
Tianhua Liu, Denghe Liu, Riqiang Liu, Hucong Jiang, Guoquan Yan, Wei Li, Lu Sun, Shu Zhang, Yinkun Liu, Kun Guo
The accuracy of current biomarkers for the diagnosis of hepatocellular carcinoma (HCC), especially chronic Hepatitis B Virus (HBV)-related HCC, is limited. Recent progress in glycoproteomics has provided a novel platform for screening novel serological biomarkers of HCC. In this study, lectin affinity chromatography by Maackia amurensis lectin (MAL) and iTRAQ combined with mass spectrometric analysis were performed to enrich and identify the glycoprotein fractions in serum samples from HBV-related HCC patients and from healthy controls...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28078875/circulating-srage-in-the-diagnosis-of-osteolytic-bone-metastasis
#9
E Galliera, M G Marazzi, E Vianello, L Drago, A Luzzati, P Bendinelli, P Maroni, L Tacchini, M A Desiderio, M M Corsi Romanelli
Despite the clinical importance of metastasis to the skeleton, the diagnostic tools for early detection and monitoring of bone metastasis lack sensitivity and specificity. We evaluated a promising new serum biomarker, the soluble form of the Receptor of Advanced Glycosylated End-products (sRAGE). sRAGE is involved in the Wnt-signaling pathway, and has been reported to reduce the risk of cancer. We investigated the diagnostic potential of sRAGE to improve the detection and monitoring of bone metastasis. We measured sRAGE in the serum of control healthy subjects, patients with primary tumors and patients with bone metastasis...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28078432/-evidence-based-recommendations-for-diagnostics-and-treatment-of-gouty-arthritis-in-the-specialist-sector-s2e-guidelines-of-the-german-society-of-rheumatology-in-cooperation-with-the-awmf
#10
REVIEW
U Kiltz, R Alten, M Fleck, K Krüger, B Manger, U Müller-Ladner, H Nüsslein, M Reuss-Borst, A Schwarting, H Schulze-Koops, A K Tausche, J Braun
Due to the increasing prevalence of gout, particularly in old age, the disease is becoming of increasing importance in Germany. Gout is one of the most common forms of recurrent inflammatory arthritis and is induced by the deposition of monosodium urate crystals in synovial fluid and other tissues. The principal goals of therapy in chronic gout are the symptomatic treatment of the acute joint inflammation and the causal treatment of the underlying metabolic cause, the hyperuricemia. Only a consistent and permanent reduction of the serum uric acid level ultimately results in an efficient avoidance of further gout attacks and therefore the prevention of structural damage...
January 11, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28077782/serum-and-tissue-markers-in-hepatocellular-carcinoma-and-cholangiocarcinoma-clinical-and-prognostic-implications
#11
REVIEW
Massimiliano Berretta, Carla Cavaliere, Lara Alessandrini, Brigida Stanzione, Gaetano Facchini, Luca Balestreri, Tiziana Perin, Vincenzo Canzonieri
HCC represents the sixth most common cancer worldwide and the second leading cause of cancer-related death. Despite the high incidence, treatment options for advanced HCC remain limited and unsuccessful, resulting in a poor prognosis. Despite the major advances achieved in the diagnostic management of HCC, only one third of the newly diagnosed patients are presently eligible for curative treatments. Advances in technology and an increased understanding of HCC biology have led to the discovery of novel biomarkers...
December 14, 2016: Oncotarget
https://www.readbyqxmd.com/read/28076311/biomarkers-of-acute-kidney-injury-the-pathway-from-discovery-to-clinical-adoption
#12
Kianoush Kashani, Wisit Cheungpasitporn, Claudio Ronco
Acute kidney injury (AKI) is a common complication of critical illnesses and has a significant impact on outcomes, including mortality and morbidities. Unfortunately, apart from prophylactic measures, no effective treatment for this syndrome is known. Therefore, early recognition of AKI not only can provide better opportunities for preventive interventions, but also opens many gates for research and development of effective therapeutic options. Over the last few years, several new AKI biomarkers have been discovered and validated to improve early detection, differential diagnosis, and differentiation of patients into risk groups for progressive renal failure, need for renal replacement therapy (RRT), or death...
January 11, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28075425/management-of-fibromyalgia-practical-guides-from-recent-evidence-based-guidelines
#13
Winfried Häuser, Jacob Ablin, Serge Perrot, Mary-Ann Fitzcharles
Fibromyalgia (FM) is a prevalent and costly condition worldwide, affecting approximately 2% of the general population. Recent evidence- and consensus-based guidelines from Canada, Germany, Israel and the European League Against Rheumatism aim to support physicians in achieving a comprehensive diagnostic work-up of patients with chronic widespread pain (CWP) and to assist patients and physicians in shared decision making on treament options. Every patient with CWP requires at the first medical evaluation a complete history, medical examination and some laboratory tests (complete blood count, C-reactive protein, serum calcium, creatine phosphokinase, thyroid stimulating hormone, 25-OH vitamin D) to screen for metabolic or inflammatory causes of CWP...
January 4, 2017: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/28075407/diagnostic-value-of-serum-angiogenesis-markers-in-ovarian-cancer-using-multiplex-immunoassay
#14
Agnieszka Horala, Agata Swiatly, Jan Matysiak, Paulina Banach, Ewa Nowak-Markwitz, Zenon J Kokot
As cancer development involves pathological vessel formation, 16 angiogenesis markers were evaluated as potential ovarian cancer (OC) biomarkers. Blood samples collected from 172 patients were divided based on histopathological result: OC (n = 38), borderline ovarian tumours (n = 6), non-malignant ovarian tumours (n = 62), healthy controls (n = 50) and 16 patients were excluded. Sixteen angiogenesis markers were measured using BioPlex Pro Human Cancer Biomarker Panel 1 immunoassay. Additionally, concentrations of cancer antigen 125 (CA125) and human epididymis protein 4 (HE4) were measured in patients with adnexal masses using electrochemiluminescence immunoassay...
January 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28070056/a-case-of-idiopathic-type-1-diabetes-with-subsequent-recovery-of-endogenous-insulin-secretion-despite-initial-diagnosis-of-fulminant-type-1-diabetes
#15
Keizo Kaneko, Chihiro Satake, Junpei Yamamoto, Hironori Takahashi, Shojiro Sawada, Junta Imai, Tetsuya Yamada, Hideki Katagiri
Fulminant type 1 diabetes is characterized by remarkably rapid and complete β-cell destruction. The established diagnostic criteria include the occurrence of diabetic ketosis soon after the onset of hyperglycemic symptoms, elevated plasma glucose with relatively low HbA1c at the first visit, and extremely low C-peptide. Serum C-peptide levels remain extremely low over a prolonged period. A 26-year-old-man with diabetic ketosis was admitted to our hospital. His relatively low HbA1c (7.6 %), despite marked hyperglycemia (593 mg/dL) with marked ketosis, indicated abrupt onset...
January 6, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28067818/the-diagnostic-usefulness-of-serum-total-bile-acid-concentrations-in-the-early-phase-of-acute-pancreatitis-of-varied-etiologies
#16
Aleksandra Maleszka, Paulina Dumnicka, Aleksandra Matuszyk, Michał Pędziwiatr, Małgorzata Mazur-Laskowska, Mateusz Sporek, Piotr Ceranowicz, Rafał Olszanecki, Marek Kuźniewski, Beata Kuśnierz-Cabala
The most common causes of acute pancreatitis (AP) are biliary tract diseases with cholestasis and alcohol consumption. In 10%-15% of patients, etiology determination is difficult. Identification of the etiology allows for the implementation of adequate treatment. The aim of this study was to assess the utility of the serum concentrations of total bile acids (TBA) to diagnose AP etiology in the early phase of the disease. We included 66 patients with AP, admitted within the first 24 h from the onset of symptoms...
January 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28067340/ultra-filtration-of-human-serum-for-improved-quantitative-analysis-of-low-molecular-weight-biomarkers-using-atr-ir-spectroscopy
#17
Franck Bonnier, Hélène Blasco, Clément Wasselet, Guillaume Brachet, Renaud Respaud, Luis Felipe C S Carvalho, Dominique Bertrand, Matthew J Baker, Hugh J Byrne, Igor Chourpa
Infrared spectroscopy is a reliable, rapid and cost effective characterisation technique, delivering a molecular finger print of the sample. It is expected that its sensitivity would enable detection of small chemical variations in biological samples associated with disease. ATR-IR is particularly suitable for liquid sample analysis and, although air drying is commonly performed before data collection, just a drop of human serum is enough for screening and early diagnosis. However, the dynamic range of constituent biochemical concentrations in the serum composition remains a limiting factor to the reliability of the technique...
January 9, 2017: Analyst
https://www.readbyqxmd.com/read/28064445/a-panel-of-autoantibodies-against-multiple-tumor-associated-antigens-for-detecting-gastric-cancer
#18
Isamu Hoshino, Matsuo Nagata, Nobuhiro Takiguchi, Yoshihiro Nabeya, Atsushi Ikeda, Sana Yokoi, Akiko Kuwajima, Masatoshi Tagawa, Kazuyuki Matsushita, Yajima Satoshi, Shimada Hideaki
Gastric cancer is the second leading cause of cancer deaths in the world, and effective diagnosis is extremely important for good outcome. We assessed the diagnostic potential of an autoantibody panel that may provide a novel tool for the early detection of gastric cancer. We analyzed data from patients with gastric cancer and normal controls in a test and validation cohorts. Autoantibody levels were measured against a panel of six tumor-associated antigens [TAAs; p53, heat shock protein 70 (HSP70), HCC-22-5, peroxiredoxin VI (Prx VI), KM-HN-1, and p90 TAA (CYP2A)] via ELISA...
January 8, 2017: Cancer Science
https://www.readbyqxmd.com/read/28063009/dna-methylation-signatures-in-circulating-cell-free-dna-as-biomarkers-for-the-early-detection-of-cancer
#19
REVIEW
Junyun Wang, Xiao Han, Yingli Sun
Detecting cell-free DNA (cfDNA) or circulating tumor DNA (ctDNA) in plasma or serum could serve as a "liquid biopsy", which would be useful for numerous diagnostic applications. cfDNA methylation detection is one of the most promising approaches for cancer risk assessment. Here, we reviewed the literature related to the use of serum or plasma circulating cell-free DNA for cancer diagnosis in the early stage and their power as future biomarkers.
January 5, 2017: Science China. Life Sciences
https://www.readbyqxmd.com/read/28061889/urinary-exosomal-activating-transcriptional-factor-3-as-the-early-diagnostic-biomarker-for-sepsis-induced-acute-kidney-injury
#20
Tanaporn Panich, Wiwat Chancharoenthana, Poorichaya Somparn, Jiraphorn Issara-Amphorn, Nattiya Hirankarn, Asada Leelahavanichkul
BACKGROUND: An early sepsis-induced acute kidney injury (sepsis-AKI) biomarker is currently in needed. Urinary neutrophil gelatinase-associated lipocalin (uNGAL) is a candidate of sepsis-AKI biomarker but with different cut-point values. Urinary exosomal activating transcriptional factor 3 (uATF3) has been mentioned as an interesting biomarker. METHODS: We conducted experiments in mice and a prospective, multicenter study in patients as a proof of concept that urine exosome is an interesting biomarker...
January 7, 2017: BMC Nephrology
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