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https://www.readbyqxmd.com/read/27916717/is-luks-pv-a-novel-experimental-therapy-for-leukemia
#1
REVIEW
Wulin Shan, Xiaoling Ma, Fang Deng
Although the studies on the pathogenesis and prognosis of leukemia have made revolutionary progress, the long-term survival remains unsatisfactory. Alternative techniques are being developed to target leukemia. Several decades after researchers' work, a variety of bacteria toxins are being explored as potential anti-leukemia agents, either to provide direct effects or to deliver therapeutic proteins to leukemia. LukS-PV, a component of Panton-Valentine Leukocidin secreted by S. aureus, has been tested in acute myeloid leukemia as a novel experimental strategy...
December 1, 2016: Gene
https://www.readbyqxmd.com/read/27902390/virulence-determinants-in-clinical-staphylococcus-aureus-from-monomicrobial-and-polymicrobial-infections-of-diabetic-foot-ulcers
#2
Kavitha Shettigar, Spoorthi Jain, Deepika V Bhat, Raviraj Acharya, Lingadakai Ramachandra, Kapaettu Satyamoorthy, T S Murali
Antibiotic resistance in Staphylococcus aureus is a major public health concern and Methicillin Resistant S. aureus has emerged as an important pathogen. We characterized S. aureus isolates from monomicrobial and polymicrobial wound infections from 200 diabetic individuals with foot ulcers to understand their underlying diversity and pathogenicity. Staphylococcal Cassette Chromosome mec typing was performed and genes coding for production of biofilm, Panton-Valentine Leukocidin, Toxic Shock Syndrome Toxin, Leukotoxins DE and M were screened...
October 19, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27899074/antibiotic-resistance-and-clonal-diversity-of-invasive-staphylococcus-aureus-in-the-rural-ashanti-region-ghana
#3
Denise Dekker, Manuel Wolters, Eva Mertens, Kennedy Gyau Boahen, Ralf Krumkamp, Daniel Eibach, Norbert G Schwarz, Yaw Adu-Sarkodie, Holger Rohde, Martin Christner, Florian Marks, Nimako Sarpong, Jürgen May
BACKGROUND: Staphylococcus aureus is among the most common pathogens isolated from blood cultures in Ghana; yet the epidemiology of blood infections in rural settings is poorly described. This study aims to investigate antimicrobial susceptibility and clonal diversity of S. aureus causing bloodstream infections in two hospitals in the Ashanti Region, Ghana. METHODS: Blood cultures were performed for all febrile patients (≥37.5 °C) on hospital admission. Antibiotic susceptibility testing for S...
November 29, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27895635/molecular-characteristic-and-virulence-gene-profiles-of-community-associated-methicillin-resistant-staphylococcus-aureus-isolates-from-pediatric-patients-in-shanghai-china
#4
Xing Wang, Xia Li, Wei Liu, Weichun Huang, Qihua Fu, Min Li
Staphylococcus aureus is a globally important human pathogen, especially among children and immunocompromised patients. The emergence and spread of community-associated methicillin-resistant S. aureus (CA-MRSA) has become a serious public health problem worldwide. The aim of this study was to investigate the prevalence, molecular characteristics and virulence profiles of CA-MRSA infections from pediatric patients in a university hospital in Shanghai, China. A total of 80 CA-MRSA isolates were collected from July 2012 to December 2013 in Shanghai Children's Medical Center and analyzed by multilocus sequence typing, staphylococcus chromosomal cassette mec (SCCmec) typing, and spa typing...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27889161/mrsa-and-multidrug-resistant-staphylococcus-aureus-in-u-s-retail-meats-2010-2011
#5
Beilei Ge, Sampa Mukherjee, Chih-Hao Hsu, Johnnie A Davis, Thu Thuy T Tran, Qianru Yang, Jason W Abbott, Sherry L Ayers, Shenia R Young, Emily T Crarey, Niketta A Womack, Shaohua Zhao, Patrick F McDermott
Methicillin-resistant Staphylococcus aureus (MRSA) has been detected in retail meats, although large-scale studies are scarce. We conducted a one-year survey in 2010-2011 within the framework of the National Antimicrobial Resistance Monitoring System. Among 3520 retail meats collected from eight U.S. states, 982 (27.9%) contained S. aureus and 66 (1.9%) were positive for MRSA. Approximately 10.4% (107/1032) of S. aureus isolates, including 37.2% (29/78) of MRSA, were multidrug-resistant (MDRSA). Turkey had the highest MRSA prevalence (3...
April 2017: Food Microbiology
https://www.readbyqxmd.com/read/27889140/genotyping-of-methicillin-resistant-staphylococcus-aureus-mrsa-isolated-from-milk-and-dairy-products-in-south-italy
#6
M G Basanisi, G La Bella, G Nobili, I Franconieri, G La Salandra
Methicillin-resistant Staphylococcus aureus (MRSA) is a pathogen emerging in hospitals as well as community and livestock. MRSA is a significant and costly public health concern because it may enter the human food chain and contaminate milk and dairy products causing foodborne illness. This study aimed to determine the occurrence and the characteristics of MRSA isolated from 3760 samples of milk and dairy products in a previous survey conducted in southern Italy during 2008-2014. Overall out of 484 S. aureus strains isolated, 40 (8...
April 2017: Food Microbiology
https://www.readbyqxmd.com/read/27869532/molecular-characterization-of-methicillin-resistant-staphylococcus-aureus-from-outpatients-in-northern-japan-increasing-tendency-of-st5-st764-mrsa-iia-with-arginine-catabolic-mobile-element
#7
Meiji Soe Aung, Mitsuyo Kawaguchiya, Noriko Urushibara, Ayako Sumi, Masahiko Ito, Kenji Kudo, Shigeo Morimoto, Shino Hosoya, Nobumichi Kobayashi
Arginine catabolic mobile element (ACME) is a genomic island of staphylococcus and is considered to confer enhanced ability to survive and growth on host bacterial cells. ACME has been typically identified in Panton-Valentine Leukocidin (PVL)-positive ST8 methicillin-resistant Staphylococcus aureus (MRSA) with SCCmec type IVa (USA300 clone), and it is also found in other lineages at low frequency. Prevalence and molecular characteristics of PVL(+)and/or ACME(+) MRSA were investigated for 624 clinical isolates collected from outpatients in northern Japan from 2013 to 2014...
November 21, 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/27868360/global-transcriptome-responses-including-small-rnas-during-mixed-species-interactions-with-methicillin-resistant-staphylococcus-aureus-and-pseudomonas-aeruginosa
#8
Christine L Miller, Tricia A Van Laar, Tsute Chen, S L Rajasekhar Karna, Ping Chen, Tao You, Kai P Leung
Pseudomonas aeruginosa and Staphylococcus aureus mixed-species biofilm infections are more resilient to biocide attacks compared to their single-species counterparts. Therefore, this study used an in vitro model recapitulating bacterial burdens seen in in vivo infections to investigate the interactions of P. aeruginosa and S. aureus in biofilms. RNA sequencing (RNA-seq) was utilized to identify the entire genomic response, both open reading frames (ORFs) and small RNAs (sRNAs), of each species. Using competitive indexes, transposon mutants validated uncharacterized PA1595 of P...
November 21, 2016: MicrobiologyOpen
https://www.readbyqxmd.com/read/27867536/life-threatening-mrsa-sepsis-with-bilateral-pneumonia-osteomyelitis-and-septic-arthritis-of-the-knee-in-a-previously-healthy-13-year-old-boy-a-case-report
#9
Nina Hardgrib, Michala Wang, Anne Grethe Jurik, Klaus K Petersen
The incidence and severity of methicillin resistant Staphylococcus aureus (MRSA) infections are increasing and cause high mortality and morbidity. We describe the first pediatric case in Scandinavia with Panton-Valentine leucocidin (PVL) positive MRSA septicemia who developed bilateral pneumonia, arthritis of the knee, and osteomyelitis of the tibia. Radiological investigation and interpretation directed the treatment, especially the surgical debridement, and combined with clinical and biochemical findings lead to close interdisciplinary treatment with frequent surgical interventions and antimicrobial combination therapy...
October 2016: Acta Radiologica Open
https://www.readbyqxmd.com/read/27848921/staphylococcus-aureus-with-panton-valentine-toxin-skin-infection-in-a-medical-laboratory-technician
#10
Richard Pougnet, Laurence Pougnet
This report exposes the case of a Staphylococcus aureus infection occurring in a microbiology laboratory technician. He was a 52 year-old man without medical history. He presented an abscess on the anterior aspect of the left forearm. Analysis showed that it was a Staphylococcus aureus secreting the Panton-Valentine toxin. The study of the workplace found the frequency of exposure. The study of workstation showed the link between the technician position and the infection. Indeed, this man touched an area where the biocleaning was hard to do...
December 1, 2016: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/27825734/predominance-of-sccmec-types-iv-and-v-among-biofilm-producing-device-associated-staphylococcus-aureus-strains-isolated-from-tertiary-care-hospitals-in-mysuru-india
#11
Pradeep Halebeedu Prakash, Vineeth Rajan, Shubha Gopal
INTRODUCTION: Device associated infections caused by Staphylococcus aureus in hospitalised patients is a serious healthcare problem. The present study was designed to determine the prevalence of biofilm-producing MRSA in device-associated infections. METHODS: Device-associated S. aureus strains (n=200) obtained from two tertiary care hospitals in Mysuru city, India were screened for biofilm production, antibiotic resistance, Panton-Valentine Leucocidin genes, SCCmec-types, spa-types, and intercellular adhesion (icaAD) dependent and independent genes...
November 5, 2016: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/27808480/prevalence-and-characteristics-of-staphylococcus-aureus-and-mrsa-nasal-colonization-among-community-based-diabetes-population-in-foshan-china
#12
Jialing Lin, Ping Xu, Yang Peng, Dongxin Lin, Qianting Ou, Ting Zhang, Chan Bai, Xiaohua Ye, Junli Zhou, Zhenjiang Yao
AIMS: Evidence suggests that diabetes may cause an increase in colonization of Staphylococcus aureus (S. aureus) and methicillin-resistant Staphylococcus aureus (MRSA) in community settings. We conducted a cross-sectional study to determine the prevalence and influencing factors of S. aureus and MRSA nasal colonization among community-based diabetes population and to identify the characteristics of the isolated strains. MATERIALS AND METHODS: 956 participants from 11 community settings were included in the study...
November 3, 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27800133/staphylococcal-cassette-chromosome-mec-types-among-methicillin-resistant-staphylococcus-aureus-in-northern-iran
#13
Akram Taherirad, Roghayeh Jahanbakhsh, Fatemeh Shakeri, Shaghayegh Anvary, Ezzat Allah Ghaemi
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is a common cause of nosocomial and community-acquired infections around the world. Staphylococcal cassette chromosome mec (SCCmec) typing methods are often used to study MRSA molecular epidemiology. OBJECTIVES: The current study was designed to explore the distribution profiles of different SCCmec types among methicillin-resistant S. aureus strains isolated from hospitals in Gorgan, in northern Iran, and to correlate the types into observed bacterial virulence factors...
August 2016: Jundishapur Journal of Microbiology
https://www.readbyqxmd.com/read/27798212/mrsa-infections-among-patients-in-the-emergency-department-a-european-multicentre-study
#14
C Bouchiat, S Curtis, I Spiliopoulou, M Bes, C Cocuzza, I Codita, C Dupieux, N Giormezis, A Kearns, F Laurent, S Molinos, R Musumeci, C Prat, M Saadatian-Elahi, E Tacconelli, A Tristan, B Schulte, F Vandenesch
BACKGROUND: MRSA is a therapeutic concern worldwide, and a major agent of community-acquired skin and soft tissue infections (CA-SSTIs). While the US epidemiology of MRSA in CA-SSTIs is well described and reports the high prevalence of the USA300 clone, data on the European situation are lacking. OBJECTIVES: To determine the prevalence and clonal characteristics of MRSA in CA-SSTIs in seven European emergency departments. PATIENTS AND METHODS: From April to June 2015, patients presenting to the tertiary hospital emergency department with a Staphylococcus aureus CA-SSTI were prospectively enrolled...
October 17, 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27792397/molecular-typing-and-virulence-gene-profiles-of-enterotoxin-gene-cluster-egc-positive-staphylococcus-aureus-isolates-obtained-from-various-food-and-clinical-specimens
#15
Minghui Song, Chunlei Shi, Xuebing Xu, Xianming Shi
The enterotoxin gene cluster (egc) has been proposed to contribute to the Staphylococcus aureus colonization, which highlights the need to evaluate genetic diversity and virulence gene profiles of the egc-positive population. Here, a total of 43 egc-positive isolates (16.2%) were identified from 266 S. aureus isolates that were obtained from various food and clinical specimens in Shanghai. Seven different egc profiles were found based on the polymerase chain reaction (PCR) result for egc genes. Then, these 43 egc-positive isolates were further typed by multilocus sequence typing, pulsed-field gel electrophoresis (PFGE), multiple-locus variable-number tandem-repeat analysis (MLVA), and accessory gene regulatory (agr) typing...
October 28, 2016: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/27790966/epidemiology-and-microbiological-characterization-of-clinical-isolates-of-staphylococcus-aureus-in-a-single-healthcare-region-of-the-uk-2015
#16
C Horner, L Utsi, L Coole, M Denton
We investigated the epidemiology and characterization of isolates of Staphylococcus aureus within the Yorkshire and Humber (YH) region in the UK. In July 2015, each laboratory within YH (n = 14) was assigned two consecutive days during which all clinical isolates of S. aureus were collected. Isolates were tested for antibiotic susceptibilities and the presence of genes encoding methicillin resistance (mecA and mecC), Panton-Valentine leukocidin (PVL) (lukS-PV), and efflux-mediated chlorhexidine resistance (qacA); isolates were also characterized by spa-types...
October 28, 2016: Epidemiology and Infection
https://www.readbyqxmd.com/read/27767912/increased-community-associated-infections-caused-by-panton-valentine-leukocidin-negative-mrsa-shanghai-2005-2014
#17
Min Li, Yanan Wang, Yuanjun Zhu, Yingxin Dai, Xufen Hong, Qian Liu, Tianming Li, Juanxiu Qin, Xiaowei Ma, Huiying Lu, Jie Xu, Michael Otto
During 2005-2014, community-associated methicillin-resistant Staphylococcus aureus infections increased in Shanghai, China. Most infections were caused by sequence type 59 S. aureus that lacked Panton-Valentine leukocidin. This finding challenges the notion that Panton-Valentine leukocidin is necessary for epidemiologic success of community-associated methicillin-resistant S. aureus.
November 2016: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27754770/molecular-and-phenotypic-characterization-revealed-high-prevalence-of-multidrug-resistant-methicillin-susceptible-staphylococcus-aureus-in-chongqing-southwestern-china
#18
Yancheng Yang, Zhen Hu, Weilong Shang, Qiwen Hu, Junmin Zhu, Jie Yang, Huagang Peng, Xiaopeng Zhang, Hui Liu, Yanguang Cong, Shu Li, Xiaomei Hu, Renjie Zhou, Xiancai Rao
Methicillin-susceptible Staphylococcus aureus (MSSA) accounts for ∼40% of staphylococcal infections in China. However, the molecular characterization of MSSA is not well described. In this study, 124 MSSA strains collected in 2013 from a comprehensive teaching hospital in Chongqing, Southwestern China, were subjected to antibiotics susceptibility testing and molecular typing, including multilocus sequence typing, staphylococcal protein A (spa) gene typing, accessory gene regulator (agr) typing, pulsed-field gel electrophoresis (PFGE) typing, Panton-Valentine leukocidin (pvl) gene detection, and antibiotic-resistant gene detection...
October 18, 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/27741135/fatal-endocarditis-with-methicilin-sensible-staphylococcus-aureus-and-major-complications-rhabdomyolysis-pericarditis-and-intracerebral-hematoma-a-case-report-and-review-of-the-literature
#19
Anca Meda Georgescu, Leonard Azamfirei, Krisztina Szalman, Edit Szekely
BACKGROUND: Over the last decades Staphylococcus aureus (SA) has become the dominant etiology of native valve infective endocarditis, with the community-acquired methicillin-sensible Staphylococcus aureus (CA-MSSA) strains being the prevailing type. CASE: We report here a case of extremely severe CA-MSSA aortic valve acute endocarditis associated with persistent Staphylococcus aureus bacteremia (SAB) in a previously healthy man and include a literature review.The patient developed severe and rare complications (purpura, purulent pericarditis, intracerebral hematoma, and rhabdomyolysis) through systemic embolism; they required drainage of pericardial empyema and cerebral hematoma, the latter eventually caused a fatal outcome...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27735802/panton-valentine-leukocidin-positive-staphylococcus-aureus-infection-in-childhood-a-case-report
#20
Arzu Karlı, Nurşen Belet, Keramettin Yanık, Özlem Köken, Mesut Kılıç, Meltem Ceyhan Bilgici, Gülnar Şensoy
Staphylococcus aureus is a common cause of musculoskeletal infections. Panton-Valentine leukocidin (PVL) is an exotoxin produced by S. aureus and is an important virulence factor. PVL-positive S. aureus infections have been associated with soft tissue infections and necrotizing pneumonia. In this case report, the clinical course of a 13-year-old boy who was admitted with right hip pain and fever, diagnosed with a gluteal abscess and incidentally discovered multiple cavitary pulmonary lesions, and had a methicillin susceptible and PVL-producing S...
November 2015: Turkish Journal of Pediatrics
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