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https://www.readbyqxmd.com/read/29454850/dissemination-of-panton-valentine-leukocidin-positive-methicillin-resistant-staphylococcus-aureus-usa300-clone-in-multiple-hospitals-in-tokyo-japan
#1
Shunsuke Takadama, Hidemasa Nakaminami, Asami Sato, Manami Shoshi, Takeshi Fujii, Norihisa Noguchi
OBJECTIVE: Panton-Valentine leukocidin (PVL) gene (lukS/F-PV)-positive community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA), particularly the USA300 clone, is a health concern worldwide. Recently, CA-MRSA clones have been found to spread and persist in hospital settings. In this study, we aimed to investigate the prevalence and molecular epidemiological features of lukS/F-PV-positive MRSA in Japanese hospitals. METHODS: A total of 3,433 MRSA isolated from nine hospitals in 2011-2015 were used...
February 15, 2018: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29442252/survey-of-staphylococcus-aureus-in-a-general-pediatric-population-and-focus-on-isolates-with-three-clinically-relevant-toxin-encoding-genes
#2
Anne Filleron, Sarah Beauregard-Birba, Thibault Mura, Fabien Aujoulat, Anne Laure Michon, Michel Rodière, Tu Anh Tran, Eric Jeziorski, Hélène Marchandin
BACKGROUND: In children, surveys on Staphylococcus aureus have focused on specific infections, situations or strains but no study has so far given an overview on S. aureus isolation without any selection. Here, we describe the overall bacteriological and clinical characteristics of S. aureus isolation in children, with a special focus on isolates harbouring tst, sea, and/or luk-PV genes, respectively, encoding the three clinically relevant toxins: toxic shock syndrome toxin-1, enterotoxin A and Panton-Valentine leukocidin...
February 13, 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29440661/panton-valentine-leukocidin-colocalizes-with-retinal-ganglion-and-amacrine-cells-and-activates-glial-reactions-and-microglial-apoptosis
#3
XuanLi Liu, Pauline Heitz, Michel Roux, Daniel Keller, Tristan Bourcier, Arnaud Sauer, Gilles Prévost, David Gaucher
Experimental models have established Panton-Valentine leukocidin (PVL) as a potential critical virulence factor during Staphylococcus aureus endophthalmitis. In the present study, we aimed to identify retinal cell targets for PVL and to analyze early retinal changes during infection. After the intravitreous injection of PVL, adult rabbits were euthanized at different time points (30 min, 1, 2, 4 and 8 h). PVL location in the retina, expression of its binding receptor C5a receptor (C5aR), and changes in Müller and microglial cells were analyzed using immunohistochemistry, Western blotting and RT-qPCR...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29409694/effective-concentration-of-intravenous-immunoglobulin-for-neutralizing-panton-valentine-leukocidin-in-human-blood
#4
Jun Tanaka, Fumihiro Hirayama, Sayuri Yanase, Shusei Uno, Takashi Nakae, Akihito Kamizono, Hideaki Hanaki
Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) infects healthy individuals, although the precise cause remains unclear. CA-MRSA produces Panton-Valentine leukocidin (PVL), which often causes severe invasive infection; however, antitoxin drugs against PVL are limited. Intravenous immunoglobulin (IVIg) possesses antitoxin activity, but unfortunately, the optimal dose is unknown. Here, we measured the PVL neutralizing antibody titer in the plasma of Japanese individuals and sera of American donors...
February 3, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/29397175/short-communication-characterization-of-staphylococcus-aureus-isolated-along-the-raw-milk-cheese-production-process-in-artisan-dairies-in-italy
#5
S Johler, G Macori, A Bellio, P L Acutis, S Gallina, L Decastelli
Staphylococcus aureus is a common cause of food-borne intoxications. Several staphylococcal food poisoning outbreaks have been linked to consumption of raw milk cheeses and artisanal cheese production. However, information on Staph. aureus isolated from artisanal raw milk cheeses and small-scale dairy production environments is very limited. Therefore, we aimed to characterize Staph. aureus isolated along the artisanal raw milk production chain by determining (1) the population structure, and (2) the presence/absence of enterotoxin genes, mecA/C, and pvl...
January 31, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29391581/panton-valentine-leukocidin-associated-with-s-aureus-osteomyelitis-activates-platelets-via-neutrophil-secretion-products
#6
Silke Niemann, Anne Bertling, Martin F Brodde, Anke C Fender, Hélène Van de Vyver, Muzaffar Hussain, Dirk Holzinger, Dirk Reinhardt, Georg Peters, Christine Heilmann, Bettina Löffler, Beate E Kehrel
Globalization and migration promote the spread of Panton-Valentine leukocidin (PVL)-positive Staphylococcus aureus strains. The toxin PVL is linked to the development of thrombosis in association with osteomyelitis. The mechanisms by which PVL drives thrombosis development are however still unknown. We demonstrate that PVL-damaged neutrophils activate platelets via neutrophil secretion products, such as α-defensins and the myeloperoxidase product HOCl, as well as the formation of HOCl-modified proteins. Neutrophil damage by PVL is blocked by anti-PVL-antibodies, explaining why especially young osteomyelitis patients with a low antibody titre against PVL suffer from thrombotic complications...
February 1, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343053/staphylococcus-aureus-producing-panton-valentine-leukocidin-an-emerging-problem-in-italian-icus
#7
Giorgia Montrucchio, Gabriele Sales, Rosario Urbino, Silvia Corcione, Rossana Cavallo, Luca Brazzi
No abstract text is available yet for this article.
January 17, 2018: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29336909/-non-reported-spa-types-in-our-country-in-staphylococcus-aureus-from-adult-patients-of-a-school-hospital-santa-fe-argentina
#8
Carla Tomatis, María R Baroni, María A Mendosa, Alicia Nagel, Analia Mollerach, Claudia Alvarez, Maria Laura Zurbriggen, Sabrina Cristobal, Glenda Segovia, Emilce de Los A Méndez
Staphylococcus aureus is a pathogen associated a different kind of infection. Molecular markers are useful tools to study microbial epidemiology. Twenty two methicillin-resistant S. aureus (MRSA) and 23 methicillin-susceptible S. aureus (MSSA) were studied by mecA gene, SCCmec cassette, Panton Valentine leucocidin (PVL) and spa polymorphism. The clinical data patients were analyzed. MSSA was prevalent in samples different from skin and soft tissue (SST) and in hospitalized patients, whereas MRSA in SST. SCCmec type IV was predominant, followed by type I...
January 11, 2018: Revista Argentina de Microbiología
https://www.readbyqxmd.com/read/29320451/the-pathogenesis-of-staphylococcus-aureus-eye-infections
#9
REVIEW
Richard J O'Callaghan
Staphylococcus aureus is a major pathogen of the eye able to infect the tear duct, eyelid, conjunctiva, cornea, anterior and posterior chambers, and the vitreous chamber. Of these infections, those involving the cornea (keratitis) or the inner chambers of the eye (endophthalmitis) are the most threatening because of their potential to cause a loss in visual acuity or even blindness. Each of these ocular sites is protected by the constitutive expression of a variety of antimicrobial factors and these defenses are augmented by a protective host response to the organism...
January 10, 2018: Pathogens
https://www.readbyqxmd.com/read/29319509/prevalence-influencing-factors-antibiotic-resistance-toxin-and-molecular-characteristics-of-staphylococcus-aureus-and-mrsa-nasal-carriage-among-diabetic-population-in-the-united-states-2001-2004
#10
Jialing Lin, Yang Peng, Chan Bai, Ting Zhang, Haoqu Zheng, Xiaojie Wang, Jiaping Ye, Xiaohua Ye, Ying Li, Zhenjiang Yao
Diabetic population were reported more likely to suffer carriage and infection with Staphylococcus aureus (S. aureus) and methicillin-resistant Staphylococcus aureus (MRSA) than non-diabetic population. We aim to elucidate the prevalence and characteristics of S. aureus and MRSA nasal carriage among diabetic population in the United States National Health and Nutrition Examination Survey, 2001-2004. Univariate analyses were conducted using Chi-square test, Fisher's exact probability test or student t test, as appropriate...
December 4, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/29317899/outbreak-of-clonal-complex-22-panton-valentine-leucocidin-positive-methicillin-resistant-staphylococcus-aureus
#11
Mark I Garvey, Craig W Bradley, Kerry L Holden, Beryl Oppenheim
Aims: We describe the investigation and control of a nosocomial outbreak of Sequence Type (ST) 22 MRSA containing the Panton-Valentine leucocidin (PVL) toxin in an acute multispecialty surgical ward at University Hospital Birmingham NHS Foundation Trust. Methods: A patient was classed as acquiring methicillin-resistant Staphylococcus aureus (MRSA) if they had a negative admission screen and then had MRSA isolated from a subsequent screen or clinical specimen. Spa typing and pulsed field gel electrophoresis (PFGE) was undertaken to confirm MRSA acquisitions...
September 2017: Journal of Infection Prevention
https://www.readbyqxmd.com/read/29261764/pyoderma-outbreak-among-kindergarten-families-association-with-a-panton-valentine-leukocidin-pvl-producing-s-aureus-strain
#12
Rasmus Leistner, Axel Kola, Petra Gastmeier, Renate Krüger, Pia-Alice Hoppe, Sylke Schneider-Burrus, Irina Zuschneid, Nicoletta Wischnewski, Jennifer Bender, Franziska Layer, Michaela Niebank, Carmen Scheibenbogen, Leif G Hanitsch
OBJECTIVES: We report on an outbreak of skin and soft tissue infections (SSTI) among kindergarten families. We analyzed the transmission route and aimed to control the outbreak. METHODS: The transmission route was investigated by nasal screening for Panton-Valentine leukocidin (PVL)-producing Staphylococcus aureus (PVL-SA), subsequent microbiological investigation including whole genome sequencing and a questionnaire-based analysis of epidemiological information...
2017: PloS One
https://www.readbyqxmd.com/read/29238933/hospital-acquired-methicillin-resistant-staphylococcus-aureus-mrsa-from-pakistan-molecular-characterisation-by-microarray-technology
#13
Bushra Jamil, Darius Gawlik, Muhammad Ali Syed, Asim Ali Shah, Shahid Ahmad Abbasi, Elke Müller, Annett Reißig, Ralf Ehricht, Stefan Monecke
The prevalence of methicillin-resistant Staphylococcus aureus (MRSA) in Pakistan is known to be high, but very few studies have described the molecular epidemiology of the different MRSA clones circulating in the country. Forty-four MRSA isolates were collected from two tertiary care hospitals of the Rawalpindi district of Pakistan. All strains were identified by a conventional phenotypic method and then subjected to genotyping by microarray hybridisation. Six clonal complexes (CCs) and 19 strains were identified...
December 14, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/29237065/methicillin-resistant-staphylococcus-aureus-in-papua-new-guinea-a-community-nasal-colonization-prevalence-study
#14
Moses Laman, Andrew Greenhill, Geoffrey W Coombs, Owen Robinson, Julie Pearson, Timothy M E Davis, Laurens Manning
Background: There are few epidemiological data available to inform a national response to community-acquired methicillin-resistant Staphylococcus aureus (MRSA) in Papua New Guinea (PNG). Methods: We performed a cross-sectional survey to determine the pattern of MRSA nasal colonization and the diversity of circulating MRSA clones among adults and adolescents in Madang Province, PNG. Results: S. aureus nasal colonization was confirmed in 44 (17...
December 11, 2017: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29234317/panton-valentine-leucocidin-pvl-as-a-potential-indicator-for-prevalence-duration-and-severity-of-staphylococcus-aureus-osteomyelitis
#15
Bei Jiang, Yinan Wang, Zihan Feng, Lei Xu, Li Tan, Shuang Zhao, Yali Gong, Cheng Zhang, Xiaoqiang Luo, Shu Li, Xiancai Rao, Yizhi Peng, Zhao Xie, Xiaomei Hu
Staphylococcus aureus is the most common cause of the difficult-to-treat osteomyelitis (OM). To better diagnose and manage S. aureus OM, especially for severe and long duration cases, indicators for risk prediction and severity evaluation are needed. Here, 139 clinical S. aureus isolates from orthopedic infections were divided into OM group (60 isolates from 60 OM patients) and non-OM group (79 isolates from 79 non-OM patients). Molecular types, antimicrobial susceptibility, and virulence factor profiles were evaluated and compared between the two groups to identify potential indicators associated with the prevalence of S...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29179212/luks-pv-regulated-microrna-125a-3p-promotes-thp-1-macrophages-differentiation-and-apoptosis-by-down-regulating-nf1-and-bcl-2
#16
Xiao-Xi Sun, Shan-Shan Zhang, Chun-Yang Dai, Jing Peng, Qing Pan, Liang-Fei Xu, Xiao-Ling Ma
BACKGROUND/AIMS: LukS-PV is a component of Panton-Valentine leukocidin (PVL). We have previously demonstrated that LukS-PV potently promoted differentiation and induced apoptosis in THP-1 cells. However, the precise mechanisms of these actions remain unknown. MicroRNAs (miRs) play important roles in cellular differentiation and apoptosis. This study aimed to investigate the role of miR-125a-3p in LukS-PV-regulated differentiation and apoptosis and its underlying mechanism in THP-1 cells...
November 27, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29174420/panton-valentine-leukocidin-positive-staphylococcus-aureus-a-position-statement-from-the-international-society-of-chemotherapy
#17
EDITORIAL
Kordo Saeed, Ian Gould, Silvano Espositio, Nusreen Ahmad-Saeed, Salman Shaheer Ahmed, Emine Alp, Abhijit M Bal, Matteo Bassetti, Eric Bonnet, Monica Chan, Geoffrey Coombs, Stephanie J Dancer, Michael Z David, Giuseppe De Simone, Matthew Dryden, Luca Guardabassi, Leif G Hanitsch, Karolin Hijazi, Renate Krüger, Andie Lee, Rasmus Leistner, Pasquale Pagliano, Elda Righi, Sylke Schneider-Burrus, Robert Leo Skov, Pierre Tattevin, Willem Van Wamel, Margreet C Vos, Andreas Voss
No abstract text is available yet for this article.
January 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29174419/co-infection-with-influenza-associated-acute-respiratory-distress-syndrome-requiring-extracorporeal-membrane-oxygenation
#18
Sacha Rozencwajg, Nicolas Bréchot, Matthieu Schmidt, Guillaume Hékimian, Guillaume Lebreton, Sébastien Besset, Guillaume Franchineau, Ania Nieszkowska, Pascal Leprince, Alain Combes, Charles-Edouard Luyt
The co-infection frequency and impact among influenza-associated acute respiratory distress syndrome (ARDS) patients requiring extracorporeal membrane oxygenation (ECMO) are not known. This retrospective observational analysis concerned data prospectively collected from patients admitted to our medical intensive care unit (ICU) who received ECMO support for influenza-associated ARDS between 2009-2016. Co-infection was defined as occurring within 48 h following ICU admission. Among the 77 ARDS patients requiring ECMO support, 39 (51%) developed co-infections, with Staphylococcus aureus [18 (46%) of the co-infected patients] being the most prevalent pathogen...
November 21, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29158906/molecular-characterization-of-panton-valentine-leukocidin-pvl-toxin-encoding-phages-from-south-india
#19
V Balaji, D B Yamuna, Y I Francis, G Priya Doss
A total of 19 methicillin-resistant Staphylococcus aureus (MRSA) isolates were investigated for Panton-Valentine leukocidin (PVL) toxin, PVL gene sequence variation and PVL-encoding phages. Whole genome sequencing was performed for all isolates. Analysis of MRSA isolates (n = 19) confirmed that most MRSA (n = 11) were positive for the PVL gene and were multidrug resistant. ST772-MRSA-V was the predominant PVL-positive MRSA clone, although all of them were found to carry the ΦIND772PVL phage in the genome...
November 2017: New Microbes and New Infections
https://www.readbyqxmd.com/read/29158405/origin-evolution-and-global-transmission-of-community-acquired-staphylococcus-aureus-st8
#20
Lena Strauß, Marc Stegger, Patrick Eberechi Akpaka, Abraham Alabi, Sebastien Breurec, Geoffrey Coombs, Beverly Egyir, Anders Rhod Larsen, Frederic Laurent, Stefan Monecke, Georg Peters, Robert Skov, Birgit Strommenger, François Vandenesch, Frieder Schaumburg, Alexander Mellmann
USA300 is a pandemic clonal lineage of hypervirulent, community-acquired, methicillin-resistant Staphylococcus aureus (CA-MRSA) with specific molecular characteristics. Despite its high clinical relevance, the evolutionary origin of USA300 remained unclear. We used comparative genomics of 224 temporal and spatial diverse S. aureus isolates of multilocus sequence type (ST) 8 to reconstruct the molecular evolution and global dissemination of ST8, including USA300. Analyses of core SNP diversity and accessory genome variations showed that the ancestor of all ST8 S...
November 20, 2017: Proceedings of the National Academy of Sciences of the United States of America
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