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adipocytokine AND adipocyte

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https://www.readbyqxmd.com/read/27882945/adiponectin-reduces-er-stress-induced-apoptosis-through-ppar%C3%AE-transcriptional-regulation-of-atf2-in-mouse-adipose
#1
Zhenjiang Liu, Lu Gan, Tianjiao Wu, Fei Feng, Dan Luo, Huihui Gu, Shimin Liu, Chao Sun
Adiponectin is a cytokine produced predominantly by adipose tissue and correlates with glucose and lipid homeostasis. However, the effects of adiponectin on endoplasmic reticulum (ER) stress and apoptosis of adipose tissue remain elusive. In this study, we found that tunicamycin-induced ER stress increased serum free fatty acid (FFA) and impaired glucose tolerance, elevated the mRNA levels of GRP78, Chop, ATF2 and caspase 3, but reduced adiponectin mRNA level in white adipose tissue. Moreover, ER stress-triggered adipocyte apoptosis by increasing cellular FFA level and Ca(2+) level...
November 24, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27714571/correlation-of-tlr4-and-klf7-in-inflammation-induced-by-obesity
#2
Cuizhe Wang, Xiaodan Ha, Wei Li, Peng Xu, Yajuan Gu, Tingting Wang, Yan Wang, Jianxin Xie, Jun Zhang
Objective Recent studies have revealed a link between toll-like receptors (TLRs), Kruppel-like factors (KLFs), and the adipose tissue inflammation associated with obesity. TLR4 is associated with chronic inflammation in obesity. KLF7 is known to play an important role in the differentiation of adipocytes, but its role in visceral adipose tissue inflammation has not yet been investigated. Thus, the objective of this study was to determine the correlation of TLR4 and KLF7 in inflammation induced by obesity. Methods A total of 32 Wistar male rat subjects were fed in the center for experimental animals of Shihezi University...
October 6, 2016: Inflammation
https://www.readbyqxmd.com/read/27583869/association-of-chemerin-levels-and-bone-mineral-density-in-chinese-obese-postmenopausal-women
#3
Liang Shi, Chaoming Mao, Xuefeng Wang, Rencong Liu, Lin Li, Xiao Mou, Ping Xu, Hongli Li, Chengcheng Xu, Guoyue Yuan, Bin Wang, Hao Zhang
Increasing evidence suggests the association between obesity and bone metabolism. However, whether excessive fat accumulation has a beneficial or adverse effect on bone health remains controversial. Chemerin is a novel adipocyte-derived hormone and a chemoattractant cytokine that regulates adipogenesis. This study was performed to investigate the associations of serum chemerin with bone mineral density (BMD) and serum pro-inflammatory cytokine levels in 543 Chinese obese postmenopausal women. BMD of the femoral neck and lumbar spine, lean mass, and fat mass were measured using dual energy X-ray absorptiometry...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27539963/adipocytes-play-an-etiological-role-in-the-podocytopathy-of-high-fat-diet-fed-rats
#4
Jinn-Yang Chen, Deng-Yuan Jian, Chih-Chan Lien, Yu-Ting Lin, Ching-Heng Ting, Luen-Kui Chen, Ting-Chia Hsu, Hsuan-Min Huang, Yu-Ting Wu, Tse-Ting Kuan, Yu-Wen Chao, Liang-Yi Wu, Seng-Wong Huang, Chi-Chang Juan
Obesity is a risk factor that promotes progressive kidney disease. Studies have shown that an adipocytokine imbalance contributes to impaired renal function in humans and animals, but the underlying interplay between adipocytokines and renal injury remains to be elucidated. We aimed to investigate the mechanisms linking obesity to chronic kidney disease. We assessed renal function in high-fat diet (HF)-fed and normal diet-fed rats, and the effects of preadipocyte- and adipocyte-conditioned medium on cultured podocytes...
August 18, 2016: Journal of Endocrinology
https://www.readbyqxmd.com/read/27459538/adipose-and-circulating-ccl18-levels-associate-with-metabolic-risk-factors-in-women
#5
Daniel Eriksson Hogling, Paul Petrus, Hui Gao, Jesper Bäckdahl, Ingrid Dahlman, Jurga Laurencikiene, Juan Acosta, Anna Ehrlund, Erik Näslund, Agne Kulyte, Niklas Mejhert, Daniel P Andersson, Peter Arner, Mikael Rydén
CONTEXT: Cardiometabolic complications in obesity may be linked to white adipose tissue (WAT) dysfunction. Transcriptomic studies of subcutaneous WAT have reported that CCL18, encoding the chemokine CCL18, is increased in obesity/insulin resistance but its functional role is unknown. OBJECTIVE: Determine if CCL18 is secreted from subcutaneous WAT and if secreted and/or serum levels associate with metabolic phenotypes. Define the primary cellular source and if CCL18 exerts effects on adipocytes...
July 26, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27430164/hmgb1-is-secreted-by-3t3-l1-adipocytes-through-jnk-signaling-and-the-secretion-is-partially-inhibited-by-adiponectin
#6
Toshiaki Shimizu, Munekazu Yamakuchi, Kamal Krishna Biswas, Bibek Aryal, Shingo Yamada, Teruto Hashiguchi, Ikuro Maruyama
OBJECTIVE: Obesity is a chronic inflammatory disease, and adipocytes contribute to obesity-associated inflammation by releasing inflammatory mediators. High mobility group box 1 (HMGB1), a highly conserved DNA-binding protein, mainly localized to cell nuclei, has been recently recognized as an innate pro-inflammatory mediator when released extracellularly. It was hypothesized that HMGB1 is an adipocytokine that acts as an innate pro-inflammatory mediator in white adipose tissue (WAT) of patients with obesity and is associated with insulin resistance...
September 2016: Obesity
https://www.readbyqxmd.com/read/27382765/-recent-advances-of-mirnas-in-adipose-tissues
#7
REVIEW
Yuntao Guo, Xiuxiu Zhang, Wanlong Huang, Xiangyang Miao
microRNAs (miRNAs), a class of endogenous non-coding RNA about 22 nucleotide long, regulate gene expression at the post-transcription level by inhibiting the translation or inducing the degradation of their target mRNAs in organisms. A lot of studies reveal that miRNAs in adipose tissues are involved in adipocyte differentiation and lipid metabolism and modulated by multiple transcription factors, adipocytokines and environmental factors, which form a complex regulatory network maintaining the homeostasis of adipose tissues...
February 2016: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/27324794/mir-146a-5p-inhibits-tnf-%C3%AE-induced-adipogenesis-via-targeting-insulin-receptor-in-primary-porcine-adipocytes
#8
Di Wu, Qian-Yun Xi, Xiao Cheng, Tao Dong, Xiao-Tong Zhu, Gang Shu, Li-Na Wang, Qing-Yan Jiang, Yong-Liang Zhang
TNF-α is a multifunctional cytokine participating in immune disorders, inflammation, and tumor development with regulatory effects on energy metabolism. Our work focused on the function of TNF-α in adipogenesis of primary porcine adipocytes. TNF-α could suppress the insulin receptor (IR) at the mRNA and protein levels. Microarray analysis of TNF-α-treated porcine adipocytes was used to screen out 29 differentially expressed microRNAs (miRNAs), 13 of which were remarkably upregulated and 16 were intensely downregulated...
August 2016: Journal of Lipid Research
https://www.readbyqxmd.com/read/27284105/nov-ccn3-a-new-adipocytokine-involved-in-obesity-associated-insulin-resistance
#9
Cécile Martinerie, Marie Garcia, Thi Thu Huong Do, Bénédicte Antoine, Marthe Moldes, Guillaume Dorothee, Chantal Kazazian, Martine Auclair, Marion Buyse, Tatiana Ledent, Pierre-Olivier Marchal, Maria Fesatidou, Adrien Beisseiche, Haruhiko Koseki, Shuichi Hiraoka, Christos Evangelos Chadjichristos, Bertrand Blondeau, Raphael Georges Denis, Serge Luquet, Bruno Fève
Identification of new adipokines that potentially link obesity to insulin resistance represents a major challenge. We recently showed that NOV/CCN3, a multifunctional matricellular protein, is synthesized and secreted by adipose tissue, with plasma levels highly correlated with BMI. NOV involvement in tissue repair, fibrotic and inflammatory diseases, and cancer has been previously reported. However, its role in energy homeostasis remains unknown. We investigated the metabolic phenotype of NOV(-/-) mice fed a standard or high-fat diet (HFD)...
September 2016: Diabetes
https://www.readbyqxmd.com/read/27274819/adipocytokines-in-renal-transplant-recipients
#10
REVIEW
Kristof Nagy, Shankar Prasad Nagaraju, Connie M Rhee, Zoltan Mathe, Miklos Z Molnar
In the last two decades, perceptions about the role of body fat have changed. Adipocytes modulate endocrine and immune homeostasis by synthesizing hundreds of hormones, known as adipocytokines. Many studies have been investigating the influences and effects of these adipocytokines and suggest that they are modulated by the nutritional and immunologic milieu. Kidney transplant recipients (KTRs) are a unique and relevant population in which the function of adipocytokines can be examined, given their altered nutritional and immune status and subsequent dysregulation of adipocytokine metabolism...
June 2016: Clinical Kidney Journal
https://www.readbyqxmd.com/read/27181269/changes-in-serum-adipocyte-fatty-acid-binding-protein-in-women-with-gestational-diabetes-mellitus-and-normal-pregnant-women-during-mid-and-late-pregnancy
#11
Ying Zhang, Hao-Hang Zhang, Jia-Hui Lu, Si-Yuan Zheng, Tao Long, Ying-Tao Li, Wei-Zhen Wu, Fang Wang
AIMS/INTRODUCTION: To observe the longitudinal changes in serum adipocyte fatty acid-binding protein (AFABP), carbohydrate, and lipid metabolism parameters in women with and without gestational diabetes mellitus (GDM) during mid- and late pregnancy periods, as well as to identify whether there is any association between AFABP and development of GDM. MATERIALS AND METHODS: A total of 40 GDM and 240 normal glucose tolerance participants were enrolled at 24-28 weeks and completed the study...
September 2016: Journal of Diabetes Investigation
https://www.readbyqxmd.com/read/27170207/aicar-attenuates-tnf%C3%AE-induced-inappropriate-secretion-of-monocyte-chemoattractant-protein-1-and-adiponectin-in-3t3-l1-adipocytes
#12
Keiko Nagahara, Kazushige Dobashi, Takuya Ishikawa, Yuya Nakano, Yoshifusa Abe, Daisuke Tanaka, Kazuo Itabashi
AIM: The increase in monocyte chemoattractant protein-1 (MCP-1) and the decrease in adiponectin production from hypertrophic adipocytes are associated with adipose tissue inflammation and its metabolic complications. The aim of this study was to determine whether 5-aminoimidazole-4-carboxamide 1-β-D-ribofuranoside (AICAR), an adenosine monophosphate-activated protein kinase (AMPK) activator, modulates these adipocytokine productions in tumor necrosis factor-α (TNFα)-treated adipocytes...
December 1, 2016: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/27150921/functional-relationship-between-arterial-tissue-and-perivascular-adipose-tissue-in-metabolic-syndrome
#13
Satomi Kagota, Saki Iwata, Kana Maruyama, Hirokazu Wakuda, Kazumasa Shinozuka
Metabolic syndrome is a complex of disorders that includes visceral obesity, insulin resistance, hypertension, and dyslipidemia. It is characterized by an increased risk for serious cardiovascular events. Adipocytes are now recognized to contribute to the development of cardiovascular complications in metabolic syndrome via the release of several bioactive substances (adipocytokines). Obesity induces an increase in the volume of perivascular adipose tissue (PVAT), which is located outside the blood vessels...
2016: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/27140496/wasabi-leaf-extracts-attenuate-adipocyte-hypertrophy-through-ppar%C3%AE-and-ampk
#14
Yasuo Oowatari, Tetsuro Ogawa, Takuya Katsube, Kiyohisa Iinuma, Hisae Yoshitomi, Ming Gao
Hypertrophy of adipocytes in obese adipose tissues causes metabolic abnormality by adipocytokine dysregulation, which promotes type 2 diabetes mellitus, hypertension, and dyslipidemia. We investigated the effects of wasabi (Wasabia japonica Matsum) leaf extracts on metabolic abnormalities in SHRSP.Z-Leprfa/IzmDmcr rats (SHRSP/ZF), which are a model of metabolic syndrome. Male SHRSP/ZF rats aged 7 weeks were divided into two groups: control and wasabi leaf extract (WLE) groups, which received water or oral treatment with 4 g/kg/day WLE for 6 weeks...
August 2016: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/27092462/adiponectin-induces-cxcl1-secretion-from-cancer-cells-and-promotes-tumor-angiogenesis-by-inducing-stromal-fibroblast-senescence
#15
Lun Cai, Shengyuan Xu, Chunmei Piao, Shulan Qiu, Huihua Li, Jie Du
Adiponectin is an adipocyte-specific adipocytokine with proliferative and pro-angiogenic effects that regulates many biological processes, including immunity, insulin resistance, and inflammation. The oncogenic role of adiponectin has been implicated in several cancer types. Stromal cells within tumor contribute tumor growth and angiogenesis; however, it is not clear that how adiponectin regulates stromal cell-mediated tumorigenesis. In this study, using the tumor xenograft models, we demonstrated that tumor development was severely impaired in mouse subcutaneous cancer tissue and metastasis tumor tissue in adiponectin knockout mice...
November 2, 2015: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/27086574/depot-and-gender-specific-expression-of-nlrp3-inflammasome-and-toll-like-receptors-in-adipose-tissue-of-cancer-patients
#16
Michio Shimabukuro, Hiromi Sato, Hirofumi Izaki, Daiju Fukuda, Etsuko Uematsu, Yoichiro Hirata, Shusuke Yagi, Takeshi Soeki, Hiroshi Sakaue, Hiro-Omi Kanayama, Hiroaki Masuzaki, Masataka Sata
Gender difference in obesity-associated cardiovascular complication could be derived from divergent chronic inflammation. We evaluated depot- and gender-specific regulation of the innate immune system in human adipose tissues. Pair samples were obtained from subcutaneous (SAT) and visceral adipose tissue (VAT) during elective surgery (Male: 35; Female: 27). Expressions of pro- and anti-inflammatory adipocytokines were evaluated by semi-quantitative qPCR. Adipose cell-size distribution was obtained from tissue samples fixed in osmium tetroxide and analyzed by Beckman Coulter Multisizer...
July 8, 2016: BioFactors
https://www.readbyqxmd.com/read/27054297/adipose-insulin-resistance-in-obese-adolescents-across-the-spectrum-of-glucose-tolerance
#17
Karen Hershkop, Omri Besor, Nicola Santoro, Bridget Pierpont, Sonia Caprio, Ram Weiss
CONTEXT: Adipocytes represent an important insulin-responsive tissue taking an active part in glucose metabolism. OBJECTIVE: This study sought to assess adipose tissue insulin resistance (IR) across the spectrum of glucose tolerance and to test its relation with free fatty acid (FFA) suppression during an oral glucose tolerance test (OGTT). DESIGN AND SETTING: A cross-sectional analysis of a pediatric clinic-derived cohort of obese adolescents...
June 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/26950427/biomolecular-features-of-inflammation-in-obese-rheumatoid-arthritis-patients-management-considerations
#18
Barbara Tolusso, Stefano Alivernini, Maria Rita Gigante, Gianfranco Ferraccioli, Elisa Gremese
Adipose tissue is an active organ playing a role not only in metabolism but also in immune and inflammatory processes, releasing several pro-inflammatory mediators. This can explain the possible association between obesity and rheumatoid arthritis (RA) and its role in the progression of the disease. Adipose and synovial tissues share common histological features of local inflammation in terms of activation of target tissues infiltrating cells (i.e. myeloid cells). Among the so-called adipocytokines, PEDF and Chemerin orchestrate the cellular cross-talk between adipose and myeloid cells, being possible biomarkers to monitor the effect of weight loss or the decrease of adipose tissue in patients with RA...
July 2016: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/26904119/prenatal-and-childhood-growth-chemerin-concentrations-and-metabolic-health-in-adult-life
#19
Johan G Eriksson, Mika Venojärvi, Clive Osmond
Several noncommunicable diseases have their origins in early developmental phases. One factor possibly explaining the association between early growth and later health could be adipocyte function. The objective of this study was to assess the association between the adipocytokine chemerin and early growth and later health. 1074 participants from Helsinki Birth Cohort Study born 1934-1944 with information on prenatal and childhood growth participated. Metabolic outcomes include glucose tolerance, adiposity, and chemerin concentration...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/26860984/targeting-the-erk-signaling-pathway-as-a-potential-treatment-for-insulin-resistance-and-type-2-diabetes
#20
Kei-Ichi Ozaki, Midori Awazu, Mayuko Tamiya, Yuka Iwasaki, Aya Harada, Satomi Kugisaki, Susumu Tanimura, Michiaki Kohno
Extracellular signal-regulated kinase (ERK) has been implicated in the development of insulin resistance associated with obesity and type 2 diabetes mellitus. Here, we examined the potential of pharmacological targeting of the ERK pathway with MEK (ERK kinase) inhibitors (PD184352 and PD0325901) for the treatment of obesity-associated insulin resistance. Thus, the effects of PD184352 and PD0325901 on the expression of adipocytokines and lipolysis activity were examined in 3T3-L1 adipocytes maintained in long-term culture as a model of adipocyte hypertrophy...
February 9, 2016: American Journal of Physiology. Endocrinology and Metabolism
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