keyword
https://read.qxmd.com/read/38520604/adherence-and-persistence-to-basal-insulin-among-people-with-type%C3%A2-2-diabetes-in-europe-a-systematic-literature-review-and-meta-analysis
#21
REVIEW
Esteban J Gimeno, Mette Bøgelund, Sara Larsen, Anna Okkels, Signe B Reitzel, Hongye Ren, Domingo Orozco-Beltran
INTRODUCTION: Diabetes is associated with a number of complications, particularly if glycaemic targets are not achieved. Glycaemic control is highly linked to treatment persistence and adherence. To understand the burden of poor persistence and adherence, this systematic literature review identified existing evidence regarding basal insulin adherence/non-adherence and persistence/non-persistence among people with diabetes in Western Europe (defined as the UK, France, Spain, Switzerland, the Netherlands, Ireland, Austria, Portugal, Denmark, Norway, Sweden, Finland, Italy, Germany, Iceland and Belgium)...
March 23, 2024: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://read.qxmd.com/read/38517864/repressing-mir-23a-promotes-the-transdifferentiation-of-pancreatic-%C3%AE-cells-to-%C3%AE-cells-via-negatively-regulating-the-expression-of-sdf-1%C3%AE
#22
JOURNAL ARTICLE
Hongmei Lang, Ning Lin, Xiaorong Chen, Jie Xiang, Xingping Zhang, Chao Kang
Pancreatic β-cell failure is a pathological feature in type 1 diabetes. One promising approach involves inducing transdifferentiation of related pancreatic cell types, specifically α cells that produce glucagon. The chemokine stromal cell-derived factor-1 alpha (SDF-1α) is implicated in pancreatic α-to-β like cell transition. Here, the serum level of SDF-1α was lower in T1D with C-peptide loss, the miR-23a was negatively correlated with SDF-1α. We discovered that exosomal miR-23a, secreted from β cells, functionally downregulates the expression of SDF-1α, leading to increased Pax4 expression and decreased Arx expression in vivo...
2024: PloS One
https://read.qxmd.com/read/38517447/sirt3-protects-retinal-pigment-epithelial-cells-from-high-glucose-induced-injury-by-promoting-mitophagy-through-the-ampk-mtor-ulk1-pathway
#23
JOURNAL ARTICLE
Wei Yang, Chen Qiu, Hongbin Lv, Zhiru Zhang, Tianyu Yao, Li Huang, Guihong Wu, Xueqin Zhang, Jie Chen, Yue He
PURPOSE: The regulation of mitophagy by Sirt3 has rarely been studied in ocular diseases. In the present study, we determined the effects of Sirt3 on AMPK/mTOR/ULK1 signaling pathway-mediated mitophagy in retinal pigment epithelial (RPE) cells in a high glucose environment. METHODS: The mRNA expression levels of Sirt3, AMPK, mTOR, ULK1, and LC3B in RPE cells under varying glucose conditions were measured by real-time polymerase chain reaction (RT-PCR). The expressions of Sirt3, mitophagy protein, and AMPK/mTOR/ULK1 signaling pathway-related proteins were detected by Western blotting...
March 1, 2024: Translational Vision Science & Technology
https://read.qxmd.com/read/38516472/nephrological-detrimental-impacts-resulting-from-novel-immunotherapy-drugs-used-in-the-treatment-of-cancer-a-systematic-review
#24
REVIEW
Amisha Jaiswal, Kainaat Shergill, Kusalik Boppana, Naiela E Almansouri, Saloni Bakkannavar, Youmna Faheem, Tuheen Sankar Nath
The most recent advancements in cancer therapy center on efficiently and conveniently enhancing a patient's natural immune system. Immune checkpoint inhibitors (ICIs) are antibodies that target cytotoxic thymus (T) lymphocyte antigen-4 (CTLA-4) and its receptor. They function by stimulating T-cell activity against malignancies. Immune-related adverse events (irAEs) are a distinct class of inflammatory side effects that are specific to a given organ. Antineoplastic medications can impact any part of the kidney, leading to the development of proteinuria, hypertension, electrolyte abnormalities, glomerulonephritis, and both acute and chronic interstitial nephritis...
February 2024: Curēus
https://read.qxmd.com/read/38516305/acid-resistant-bodipy-amino-acids-for-peptide-based-fluorescence-imaging-of-gpr54-receptors-in-pancreatic-islets
#25
JOURNAL ARTICLE
Lorena Mendive-Tapia, Laia Miret-Casals, Nicole D Barth, Jinling Wang, Anne de Bray, Massimiliano Beltramo, Vincent Robert, Christophe Ampe, David J Hodson, Annemieke Madder, Marc Vendrell
The G protein-coupled kisspeptin receptor (GPR54 or KISS1R) is an important mediator in reproduction, metabolism and cancer biology; however, there are limited fluorescent probes or antibodies for direct imaging of these receptors in cells and intact tissues, which can help to interrogate their multiple biological roles. Herein, we describe the rational design and characterization of a new acid-resistant BODIPY-based amino acid (Trp-BODIPY PLUS), and its implementation for solid-phase synthesis of fluorescent bioactive peptides...
May 8, 2023: Angewandte Chemie
https://read.qxmd.com/read/38515146/effect-of-an-entry-to-care-intervention-on-diabetes-distress-in-individuals-with-newly-diagnosed-type-2-diabetes-a-study-protocol-for-a-cluster-randomized-trial
#26
JOURNAL ARTICLE
Steffan Holst Hansen, Troels Mygind Jensen, Gitte Stentebjerg Petersen, Francois Pouwer, Anders L Sønderlund, Jens Søndergaard
BACKGROUND: Diabetes distress (DD) affects at least 36% of T2DM patients and is often associated with insufficient support and care. This study examines an intervention that targets DD through enhanced cross-sectoral collaboration and treatment during the first 3 months following diagnosis. The intervention aims to improve care and self-management and to reduce DD. METHODS AND INTERVENTION: The study is designed as a cluster-randomized trial with the intervention focusing on four key elements of diabetes care: effective cross-sectoral communication and information sharing, systematic care, a "one-stop-shop" health screening and start-up conversation at the municipality, and improving patient insights into own care...
March 21, 2024: Trials
https://read.qxmd.com/read/38513987/the-association-between-interleukin-family-and-diabetes-mellitus-and-its-complications-an-overview-of-systematic-reviews-and-meta-analyses
#27
REVIEW
Zishan Jin, Qiqi Zhang, Ke Liu, Sicheng Wang, Yan Yan, Boxun Zhang, Linhua Zhao
OBJECTIVE: To evaluate and summarize the association between interleukin (IL) concentrations and diabetes mellitus (DM) and its complications. METHODS: Meta-analyses and eligible individual studies of observational studies investigating the associations between IL and DM and its complications were included. The random-effects model was used to estimate the summary effect, and the heterogeneity among studies was assessed using the Q-statistic and the I2 metric; The Egger's regression and the χ2 test were used to test for small study effects and excess significance bias...
March 19, 2024: Diabetes Research and Clinical Practice
https://read.qxmd.com/read/38512439/aqp4-endocytosis-lysosome-degradation-mediated-by-mmp-9-%C3%AE-dg-involved-in-diabetes-cognitive-impairment
#28
JOURNAL ARTICLE
Ye Yuan, Wei Peng, Jingna Lei, Yi Zhao, Beiyu Zhao, Yan Li, Jin Wang, Qiumin Qu
Cognitive impairment is considered to be one of the important comorbidities of diabetes, but the underlying mechanisms are widely unknown. Aquaporin-4 (AQP4) is the most abundant water channel in the central nervous system, which plays a neuroprotective role in various neurological diseases by maintaining the function of glymphatic system and synaptic plasticity. However, whether AQP4 is involved in diabetes-related cognitive impairment remains unknown. β-dystroglycan (β-DG), a key molecule for anchoring AQP4 on the plasma membrane of astrocytes and avoiding its targeting to lysosomes for degradation, can be cleaved by matrix metalloproteinase-9 (MMP-9)...
March 21, 2024: Molecular Neurobiology
https://read.qxmd.com/read/38509409/ferroptosis-mechanisms-and-regulations-in-cardiovascular-diseases-in-the-past-present-and-future
#29
REVIEW
Wenxi Fang, Saiyang Xie, Wei Deng
Cardiovascular diseases (CVDs) are the main diseases that endanger human health, and their risk factors contribute to high morbidity and a high rate of hospitalization. Cell death is the most important pathophysiology in CVDs. As one of the cell death mechanisms, ferroptosis is a new form of regulated cell death (RCD) that broadly participates in CVDs (such as myocardial infarction, heart transplantation, atherosclerosis, heart failure, ischaemia/reperfusion (I/R) injury, atrial fibrillation, cardiomyopathy (radiation-induced cardiomyopathy, diabetes cardiomyopathy, sepsis-induced cardiac injury, doxorubicin-induced cardiac injury, iron overload cardiomyopathy, and hypertrophic cardiomyopathy), and pulmonary arterial hypertension), involving in iron regulation, metabolic mechanism and lipid peroxidation...
March 21, 2024: Cell Biology and Toxicology
https://read.qxmd.com/read/38507994/tyrosine-nitration-of-glucagon-impairs-its-function-extending-the-role-of-heme-in-t2d-pathogenesis
#30
JOURNAL ARTICLE
Xiaoying Yin, Guoqi Ni, Xuan Zhang, Shitao Fu, Hailing Li, Zhonghong Gao
New studies raise the possibility that the higher glucagon (GCG) level present in type 2 diabetes (T2D) is a compensatory mechanism to enhance β-cell function, rather than induce dysregulated glucose homeostasis, due to an important role for GCG that acts directly within the pancreas on insulin secretion by intra-islet GCG signaling. However, in states of poorly controlled T2D, pancreatic α cell mass increases (overproduced GCG) in response to insufficient insulin secretion, indicating decreased local GCG activity...
March 12, 2024: Journal of Inorganic Biochemistry
https://read.qxmd.com/read/38505420/traditional-chinese-medicine-and-its-active-substances-reduce-vascular-injury-in-diabetes-via-regulating-autophagic-activity
#31
REVIEW
Yankui Gao, Lei Zhang, Fei Zhang, Rong Liu, Lei Liu, Xiaoyan Li, Xiangdong Zhu, Yonglin Liang
Due to its high prevalence, poor prognosis, and heavy burden on healthcare costs, diabetic vascular complications have become a significant public health issue. Currently, the molecular and pathophysiological mechanisms underlying diabetes-induced vascular complications remain incompletely understood. Autophagy, a highly conserved process of lysosomal degradation, maintains intracellular homeostasis and energy balance via removing protein aggregates, damaged organelles, and exogenous pathogens. Increasing evidence suggests that dysregulated autophagy may contribute to vascular abnormalities in various types of blood vessels, including both microvessels and large vessels, under diabetic conditions...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38504565/identification-of-pdgfa-as-a-neutrophil-related-biomarker-linked-to-the-advancement-of-diabetic-retinopathy-through-integrated-bioinformatics-analysis
#32
JOURNAL ARTICLE
Anran Liang, Tingting Feng, Xiang Gao, Bowen Zhao, Song Chen
BACKGROUND: The dysregulation of the innate immune system plays a crucial role in the development of Diabetic Retinopathy (DR). To gain an insight into the underlying mechanism of DR, it is essential to identify specific biomarkers associated with immune cell infiltration. METHODS: In this study, we retrieved the GSE94019 and GSE60436 datasets from the Gene Expression Omnibus (GEO) database. By utilizing CIBERSORT, MCPcounter, and xCell algorithms, we conducted a comprehensive analysis of the immune cell infiltration landscape in DR...
March 19, 2024: Endocrine, Metabolic & Immune Disorders Drug Targets
https://read.qxmd.com/read/38504316/protective-effects-of-imeglimin-on-the-development-of-atherosclerosis-in-apoe-ko-mice-treated-with-stz
#33
JOURNAL ARTICLE
Junpei Sanada, Tomohiko Kimura, Masashi Shimoda, Yuichiro Iwamoto, Hideyuki Iwamoto, Kazunori Dan, Yoshiro Fushimi, Yukino Katakura, Yuka Nogami, Yoshiko Shirakiya, Yuki Yamasaki, Tomoko Ikeda, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
BACKGROUND: Imeglimin is a new anti-diabetic drug which promotes insulin secretion from pancreatic β-cells and reduces insulin resistance in insulin target tissues. However, there have been no reports examining the possible anti-atherosclerotic effects of imeglimin. In this study, we investigated the possible anti-atherosclerotic effects of imeglimin using atherosclerosis model ApoE KO mice treated with streptozotocin (STZ). METHODS: ApoE KO mice were divided into three groups: the first group was a normoglycemic group without injecting STZ (non-DM group, n = 10)...
March 19, 2024: Cardiovascular Diabetology
https://read.qxmd.com/read/38500351/new-insights-into-nanomedicines-for-oral-delivery-of-glucagon-like-peptide-1-analogs
#34
REVIEW
Soraia Filipa Tavares Pinto, Hélder Almeida Santos, Bruno Filipe Carmelino Cardoso Sarmento
Type 2 diabetes mellitus (T2DM) is a metabolic disorder that arises when the body cannot respond fully to insulin, leading to impaired glucose tolerance. Currently, the treatment embraces non-pharmacological actions (e.g., diet and exercise) co-associated with the administration of antidiabetic drugs. Metformin is the first-line treatment for T2DM; nevertheless, alternative therapeutic strategies involving glucagon-like peptide-1 (GLP-1) analogs have been explored for managing the disease. GLP-1 analogs trigger insulin secretion and suppress glucagon release in a glucose-dependent manner thereby, reducing the risk of hyperglycemia...
2024: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://read.qxmd.com/read/38497748/nogo-b-promotes-endoplasmic-reticulum-stress-mediated-autophagy-in-endothelial-cells-of-diabetic-nephropathy
#35
JOURNAL ARTICLE
Yan Zhang, Peimin Liu, Shanzhi Yang, Jinyi Lan, Haosen Xu, Huan Jiang, Li Jiaoqing, Ting Zhang, Hong Zhang, Wenjuan Duan, Luigi Gnudi, Xiaoyan Bai
AIMS: Endothelial cells are the critical targets of injury in diabetic nephropathy (DN) and endothelial cell lesions contribute to the disease progression. Neurite outgrowth inhibitor B (Nogo-B), an endoplasmic reticulum (ER)-resident protein, plays a pivotal role in vascular remodeling after injury and maintains the structure and function of the endoplasmic reticulum. Yet the role of Nogo-B in the regulation of ER stress and endothelial cell injury remains largely unknown. Herein, we tested the hypothesis that Nogo-B activates ER stress-mediated autophagy and protects endothelial cells in diabetic nephropathy...
March 18, 2024: Antioxidants & Redox Signaling
https://read.qxmd.com/read/38497734/oxidative-stress-endothelial-dysfunction-and-n-acetylcysteine-in-type-2-diabetes-mellitus
#36
JOURNAL ARTICLE
Xin Li, Junyong Zou, Aiping Lin, Jingshu Chi, Hong Hao, Hong Chen, Zhenguo Liu
Cardiovascular diseases (CVDs) remain the leading cause of morbidity and mortality globally. Endothelial dysfunction is closely associated with the development and progression of CVDs. Patients with diabetes mellitus (DM) especially type-2 DM exhibit a significant endothelial cell dysfunction with substantially increased risk for CVDs. Excessive reactive oxygen species (ROS) and oxidative stress are important contributing factors to endothelial cell dysfunction and subsequent CVDs. ROS production is significantly increased in DM and is critically involved in the development of endothelial dysfunction in diabetic patients...
March 18, 2024: Antioxidants & Redox Signaling
https://read.qxmd.com/read/38496622/cell-state-dependent-regulation-of-ppar-%C3%AE-signaling-by-zbtb9-in-adipocytes
#37
Xuan Xu, Alyssa Charrier, Sunny Congrove, David A Buchner
Adipocytes play a critical role in metabolic homeostasis. Peroxisome proliferator-activated receptor- γ (PPAR γ ) is a nuclear hormone receptor that is a master regulator of adipocyte differentiation and function. ZBTB9 was predicted to interact with PPAR γ based on large-scale protein interaction experiments. In addition, GWAS studies in the type 2 diabetes (T2D) Knowledge Portal revealed associations between Z btb9 and both BMI and T2D risk. Here we show that ZBTB9 positively regulates PPAR γ activity in mature adipocytes...
March 6, 2024: bioRxiv
https://read.qxmd.com/read/38493698/elevated-expression-of-lcn13-through-fxr-activation-ameliorates-hepatocellular-lipid-accumulation-and-inflammation
#38
JOURNAL ARTICLE
Xingliang Qin, Yongyao Tan, Weishu Ren, Weiwei Zhou, Rouxi Niu, Linyue Liang, Jinling Li, Kaiyuan Cao, Guohong Wei, Xun Zhu, Mingxing Huang
BACKGROUND: Lipocalin 13 (LCN13) is a member of the lipocalin family that consists of numerous secretory proteins. LCN13 high-expression has been reported to possess anti-obesity and anti-diabetic effects. Although metabolic dysfunction-associated steatotic liver diseases (MASLD) including metabolic dysfunction-associated steatohepatitis (MASH) are frequently associated with obesity and insulin resistance, the functional role of endogenous LCN13 and the therapeutic effect of LCN13 in MASH and related metabolic deterioration have not been evaluated...
March 16, 2024: International Immunopharmacology
https://read.qxmd.com/read/38492358/deciphering-the-role-of-micrornas-in-diabetic-nephropathy-regulatory-mechanisms-and-molecular-insights
#39
REVIEW
Nourhan M Abdelmaksoud, Tohada M Al-Noshokaty, Rehab Abdelhamid, Nourhan Abdellatif, Abdallah Mansour, Reem Mohamed, Asmaa Hamouda Mohamed, Nada Abd Elatif Khalil, Sara Sobhy Abdelhamid, Alaa Mohsen, Heba Abdelaal, Ahmed Tawfik, Shereen Saeid Elshaer
A serious consequence of diabetes mellitus, diabetic nephropathy (DN) which causes gradual damage to the kidneys. Dietary changes, blood pressure control, glucose control, and hyperlipidemia are all important components of DN management. New research, however, points to microRNAs (miRNAs) as having a pivotal role in DN pathogenesis. Miniature non-coding RNA molecules such as miRNAs control gene expression and impact several biological processes. The canonical and non-canonical routes of miRNA biogenesis are discussed in this article...
March 4, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38488828/new-approach-to-equitable-intervention-planning-to-improve-engagement-and-outcomes-in-a-digital-health-program-simulation-study
#40
JOURNAL ARTICLE
Jackson A Killian, Manish Jain, Yugang Jia, Jonathan Amar, Erich Huang, Milind Tambe
BACKGROUND: Digital health programs provide individualized support to patients with chronic diseases and their effectiveness is measured by the extent to which patients achieve target individual clinical outcomes and the program's ability to sustain patient engagement. However, patient dropout and inequitable intervention delivery strategies, which may unintentionally penalize certain patient subgroups, represent challenges to maximizing effectiveness. Therefore, methodologies that optimize the balance between success factors (achievement of target clinical outcomes and sustained engagement) equitably would be desirable, particularly when there are resource constraints...
March 15, 2024: JMIR Diabetes
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