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https://www.readbyqxmd.com/read/28342940/high-test-retest-reliability-of-pain-related-evoked-potentials-prep-in-healthy-subjects
#1
Özüm Simal Özgül, Christoph Maier, Elena K Enax-Krumova, Jan Vollert, Marc Fischer, Martin Tegenthoff, Oliver Höffken
Pain-related-evoked potentials (PREP) is an established electrophysiological method to evaluate the signal transmission of electrically stimulated A-delta fibres. Although prerequisite for its clinical use, test-retest-reliability and side-to-side differences of bilateral stimulation in healthy subjects have not been examined yet. We performed PREP twice within 3 to 14days in 33 healthy subjects bilaterally by stimulating the dorsal hand. Detection (DT) and pain thresholds (PT) after electrical stimulation, the corresponding pain ratings, latencies of P0, N1, P1 and N2 components and the corresponding amplitudes were assessed...
March 22, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28323447/injury-mitigation-estimates-for-an-intersection-driver-assistance-system-in-straight-crossing-path-crashes-in-the-u-s
#2
John M Scanlon, Rini Sherony, Hampton C Gabler
OBJECTIVE: Accounting for one-fifth of all crashes and one-sixth of all fatal crashes in the U.S., intersection crashes are among the most frequent and fatal crash modes. Intersection Advanced Driver Assistance Systems (I-ADAS) are emerging vehicle-based active safety systems that aim to help drivers safely navigate intersections. The objective of this study was to estimate the number of crashes and number of vehicles with a seriously injured driver (MAIS3+) that could be prevented or reduced if, for every straight crossing path (SCP) intersection crash, one of the vehicles had been equipped with an I-ADAS...
March 21, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28267532/r2-relaxometry-of-the-pancreas-in-patients-with-human-hemochromatosis-protein-associated-hereditary-hemochromatosis
#3
B Henninger, S Rauch, H Zoller, M Plaikner, W Jaschke, C Kremser
PURPOSE: To evaluate pancreatic iron in patients with human hemochromatosis protein associated hereditary hemochromatosis (HHC) using R2* relaxometry. MATERIALS AND METHODS: 81 patients (58 male, 23 female; median age 49.5, range 10-81 years) with HHC were retrospectively studied. All underwent 1.5T magnetic resonance imaging (MRI) of the abdomen. A fat-saturated multi-gradient echo sequence with 12 echoes (TR=200ms; TE-initial 0.99ms; Delta-TE 1.41ms; 12 echoes; flip-angle: 20°) was used for the R2* quantification of the liver and the pancreas...
April 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28265243/altered-intermittent-rhythmic-delta-and-theta-activity-in-the-electroencephalographies-of-high-functioning-adult-patients-with-autism-spectrum-disorder
#4
Dominique Endres, Simon Maier, Bernd Feige, Nicole A Posielski, Kathrin Nickel, Dieter Ebert, Andreas Riedel, Alexandra Philipsen, Evgeniy Perlov, Ludger Tebartz van Elst
Background: Autism spectrum disorder (ASD) is often associated with epilepsy. Previous studies have also shown increased rates of electroencephalographic (EEG) alteration in ASD patients without epilepsy. The aim of this study was to compare the rate of intermittent rhythmic delta and theta activity (IRDA/IRTA) events between high-functioning adult patients with ASD and matched healthy controls. Materials and Methods: Routine EEG records of 19 ASD patients and 19 matched controls were screened for IRDA/IRTA using a fully data driven analysis with fixed thresholds...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28251078/vasoactive-intestinal-peptide-a-promising-agent-for-myopia
#5
Ayse Idil Cakmak, Hikmet Basmak, Huseyin Gursoy, Mete Ozkurt, Nilgun Yildirim, Nilufer Erkasap, Mustafa Deger Bilgec, Nese Tuncel, Ertugrul Colak
AIM: To investigate the role of vasoactive intestinal peptide (VIP) in form-deprivation myopia (FDM). METHODS: FDM was created in three groups of eight chicks by placing a translucent diffuser on their right eyes. Intravitreal injections of saline and VIP were applied once a day into the occluded eyes of groups 2 and 3, respectively. Retinoscopy and axial length (AL) measurements were performed on the first and 8(th) days of diffuser wear. The retina mRNA levels of the VIP receptors and the ZENK protein in right eyes of the three groups and left eyes of the first group on day 8 were determined using real time polymerase chain reaction (PCR)...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28250407/mechanical-stimulus-induced-wthdrawal-behavior-increases-subsequent-pre-stimulus-local-field-potential-power-in-the-rostral-anterior-cingulate-cortex-in-unanesthetized-rats
#6
Zui Shen, Jing Sun, Boyi Liu, Yongliang Jiang, Yuanyuan Wu, Jialing Wang, Xiaomei Shao, Jianqiao Fang
BACKGROUND The rostral anterior cingulate cortex (rACC) is important in pain expectation. Previous studies demonstrated that mechanical stimulus-induced withdrawal behaviors are spinally-mediated nocifensive reflexes in rats, but it is not known whether pain expectation is influenced by withdrawal behaviors. MATERIAL AND METHODS We reanalyzed previous mechanosensitivity measurements of 244 rats measured 5 times in succession. To study neural oscillation in the rACC, 1 recording microwire array was surgically implanted...
March 2, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28230056/threshold-of-long-term-survival-of-a-coastal-delphinid-in-anthropogenically-degraded-environment-indo-pacific-humpback-dolphins-in-pearl-river-delta
#7
Leszek Karczmarski, Shiang-Lin Huang, Stephen C Y Chan
Defining demographic and ecological threshold of population persistence can assist in informing conservation management. We undertook such analyses for the Indo-Pacific humpback dolphin (Sousa chinensis) in the Pearl River Delta (PRD) region, southeast China. We use adult survival estimates for assessments of population status and annual rate of change. Our estimates indicate that, given a stationary population structure and minimal risk scenario, ~2000 individuals (minimum viable population in carrying capacity, MVPk) can maintain the population persistence across 40 generations...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28226029/predictive-value-of-c-reactive-protein-in-critically-ill-patients-after-abdominal-surgery
#8
Frédéric Sapin, Patrick Biston, Michael Piagnerelli
OBJECTIVES: The development of sepsis after abdominal surgery is associated with high morbidity and mortality. Due to inflammation, it may be difficult to diagnose infection when it occurs, but measurement of C-reactive protein could facilitate this diagnosis. In the present study, we evaluated the predictive value and time course of C-reactive protein in relation to outcome in patients admitted to the intensive care unit (ICU) after abdominal surgery. METHODS: We included patients admitted to the ICU after abdominal surgery over a period of two years...
January 1, 2017: Clinics
https://www.readbyqxmd.com/read/28208704/basic-send-on-delta-sampling-for-signal-tracking-error-reduction
#9
Miguel Diaz-Cacho, Emma Delgado, Antonio Barreiro, Pablo Falcón
This paper investigates the dynamic selection of an appropriate threshold for basic Send-on-Delta (SoD) sampling strategies, given an available transmission rate to reduce the signal tracking-error. The paper formulates the error-reduction principle and proposes an algorithm that calculates, in real time, the amplitude threshold value (also called delta value) for a desired mean transmission rate. The algorithm is implemented to be computed in a Send-on-Delta driver and is tested with three signals that match the step response of a second order control system...
February 8, 2017: Sensors
https://www.readbyqxmd.com/read/28174242/diversity-of-fate-outcomes-in-cell-pairs-under-lateral-inhibition
#10
Nara Guisoni, Rosa Martinez-Corral, Jordi Garcia Ojalvo, Joaquín de Navascués
Cell fate determination by lateral inhibition via Notch/Delta signalling has been extensively studied. Most formalised models consider Notch/Delta interactions in fields of cells, with parameters that typically lead to symmetry breaking of signalling states between neighbouring cells, commonly resulting in salt-and-pepper fate patterns. Here we consider the case of signalling between isolated cell pairs, and find that the bifurcation properties of a standard mathematical model of lateral inhibition can lead to stable symmetric signalling states...
February 7, 2017: Development
https://www.readbyqxmd.com/read/28157665/inhibition-of-cancer-migration-and-invasion-by-knocking-down-delta-5-desaturase-in-cox-2-overexpressed-cancer-cells
#11
Xiaoyu Yang, Yi Xu, Tao Wang, Dan Shu, Peixuan Guo, Keith Miskimins, Steven Y Qian
We recently reported that knockdown of delta-5-desaturase (a key enzyme that converts dihomo-γ-linolenic acid, DGLA, to the downstream ω-6 arachidonic acid) promotes formation of an anti-cancer byproduct 8-hydroxyoctanoic acid from cyclooxygenase (COX)-catalyzed DGLA peroxidation. 8-hydroxyoctanoic acid can exert its growth inhibitory effect on cancer cells (e.g. colon and pancreatic cancer) by serving as a histone deacetylase inhibitor. Since histone deacetylase inhibitors have been well-known to suppress cancer cell migration and invasion, we thus tested whether knockdown of delta-5-desaturase and DGLA treatment could also be used to inhibit cancer migration and invasion of colon cancer and pancreatic cancer cells...
April 2017: Redox Biology
https://www.readbyqxmd.com/read/28074227/heavy-metals-in-liver-and-brain-of-waterfowl-from-the-evros-delta-greece
#12
Maria Aloupi, Asimina Karagianni, Savas Kazantzidis, Triantaphyllos Akriotis
The concentrations of six heavy metals (cadmium [Cd], chromium [Cr], copper [Cu], manganese [Mn], lead [Pb], and zinc [Zn]) were determined in liver and brain of nine species of waterfowl from the Evros Delta, one of the most important wetlands in Greece, to assess metal contamination and potential risk to waterfowl. Significant differences among species were found for hepatic Cr, Cu, Pb, and Zn; the highest levels of all metals were found in liver of mute swans. Cd increased significantly with age in both organs of wigeon; some differences were also observed between males and females of the same species...
February 2017: Archives of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28047649/su-g-jep1-04-characterization-of-a-high-definition-optical-patient-surface-tracking-system-across-five-installations
#13
T Smith, A Ayan, E Cochran, J Woollard, N Gupta
PURPOSE: To assess the performance of Varian's real-time, Optical Surface Monitoring System (OSMS) by measuring relative regular and irregular surface detection accuracy in 6 degrees of motion (6DoM), across multiple installations. METHODS: Varian's Intracranial SRS Package includes OSMS, which utilizes 3 HD camera/projector pods to map a patient surface, track intra-fraction motion, and gate the treatment beam if motion exceeds a threshold. To evaluate motion-detection accuracy of OSMS, we recorded shifts of a cube-shaped phantom on a single Varian TrueBeam linear accelerator as known displacements were performed incrementally across 6DoM...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28025746/gender-specific-differences-in-baseline-peak-and-delta-serum-creatinine-the-nacseld-experience
#14
Jacqueline G O'Leary, Florence Wong, K Rajender Reddy, Guadalupe Garcia-Tsao, Patrick S Kamath, Scott W Biggins, Michael B Fallon, Ram M Subramanian, B Maliakkal, Leroy Thacker, Jasmohan S Bajaj
BACKGROUND: Women have lower serum creatinine values than men for similar renal function. AIMS: We aimed to determine the differential effect of baseline, peak, and delta creatinine between genders on outcomes in infected hospitalized cirrhotic patients. METHODS: North American Consortium for the Study of End-Stage Liver Disease is a 15-center consortium of tertiary care hepatology centers prospectively enrolling infected cirrhotic inpatients...
March 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27965144/mapping-of-schistosoma-mansoni-in-the-nile-delta-egypt-assessment-of-the-prevalence-by-the-circulating-cathodic-antigen-urine-assay
#15
Ayat A Haggag, Amal Rabiee, Khaled M Abd Elaziz, Albis F Gabrielli, Rehab Abdel Hay, Reda M R Ramzy
In line with WHO recommendations on elimination of schistosomiasis, accurate identification of all areas of residual transmission is a key step to design and implement measures aimed at interrupting transmission in low-endemic settings. To this purpose, we assessed the prevalence of active S. mansoni infection in five pilot governorates in the Nile Delta of Egypt by examining schoolchildren (6-15 years) using the Urine-Circulating Cathodic Antigen (Urine-CCA) cassette test; we also carried out the standard Kato-Katz (KK) thick smear, the monitoring and evaluation tool employed by Egypt's national schistosomiasis control programme...
March 2017: Acta Tropica
https://www.readbyqxmd.com/read/27942006/ground-squirrel-shooting-and-potential-lead-exposure-in-breeding-avian-scavengers
#16
Garth Herring, Collin A Eagles-Smith, Mason T Wagner
Recreational ground squirrel shooting is a popular activity throughout the western United States and serves as a tool for managing ground squirrel populations in agricultural regions. Belding's ground squirrels (Spermophilus beldingi) are routinely shot in California, Nevada, and Oregon across habitats that overlap with breeding avian scavengers. Ground squirrels shot with lead (Pb)-based bullets may pose a risk to avian scavengers if they consume carcasses containing Pb fragments. To assess the potential risk to breeding avian scavengers we developed a model to estimate the number, mass, and distribution of Pb fragments in shot ground squirrels using radiographic images...
2016: PloS One
https://www.readbyqxmd.com/read/27888117/testing-assumptions-in-human-pain-models-psychophysical-differences-between-first-and-second-pain
#17
Nathanial R Eckert, Charles J Vierck, Corey B Simon, Yenisel Cruz-Almeida, Roger B Fillingim, Joseph L Riley
Acute pain arises from activation of myelinated (A delta) and unmyelinated (C) nociceptive afferents, leading to first (A-fiber) or second (C-fiber) pain sensations. The current study sought to investigate first and second pain within glabrous and hairy skin sites in human upper limbs. Fifty healthy adults (25 male/25 female, 18-30 years old, mean = 20.5 ± 1.4 years) participated in a psychophysical study investigating electronically rated, thermal first and second pain sensations within the glabrous skin at the palm and hairy skin of the forearm...
March 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/27883985/a-systematic-review-of-passive-exposure-to-cannabis
#18
REVIEW
Aurélie Berthet, Mariangela De Cesare, Bernard Favrat, Frank Sporkert, Marc Augsburger, Aurélien Thomas, Christian Giroud
Passive exposure to cannabis smoke may induce effects on behavior and psychomotor skills, and have legal consequences, including the risk of being falsely considered as a cannabis user. This can become a concern, especially in occupational contexts or when driving vehicles. In order to enable a differentiation between a passive and an active exposure to cannabis and to limit the likeliness to be detected positive following passive exposure, this review identified specific biomarkers of passive exposure in urine, blood, oral fluid, hair, and sebum...
December 2016: Forensic Science International
https://www.readbyqxmd.com/read/27880976/a-novel-quantitative-microarray-antibody-capture-q-mac-assay-identifies-an-extremely-high-hdv-prevalence-amongst-hbv-infected-mongolians
#19
Xiaohua Chen, Odgerel Oidovsambuu, Ping Liu, Rosslyn Grosely, Menashe Elazar, Virginia D Winn, Benjamin Fram, Zhang Boa, Hongjie Dai, Bekhbold Dashtseren, Dahgwahdorj Yagaanbuyant, Zulkhuu Genden, Naranbaatar Dashdorj, Andreas Bungert, Naranjargal Dashdorj, Jeffrey S Glenn
Hepatitis delta virus (HDV) causes the most severe form of human viral hepatitis. HDV requires a hepatitis B virus (HBV) co-infection to provide HDV with HBV surface antigen envelope proteins. The net effect of HDV is to make the underlying HBV disease worse, including higher rates of hepatocellular carcinoma (HCC). Accurate assessments of current HDV prevalence have been hampered by the lack of readily available and reliable quantitative assays, combined with the absence of an FDA-approved therapy. We sought to develop a convenient assay for accurately screening populations and to use this assay to determine HDV prevalence in a population with abnormally high rates of HCC...
November 23, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27822694/occurrence-sources-and-risk-assessment-of-ocps-in-surface-sediments-from-urban-rural-and-reclamation-affected-rivers-of-the-pearl-river-delta-china
#20
Wei Wang, Junhong Bai, Min Xi, Qingqing Zhao, Guangliang Zhang, Xiaojun Wen, Rong Xiao
Sediments were collected to a depth of 20 cm from urban, rural, and reclamation-affected rivers in the Pearl River Delta of China. In total, 16 organochlorine pesticides (OCPs) were analyzed in all sediment samples, and the occurrence, possible sources, toxicity, and health risks of OCPs were evaluated to compare the contamination characteristics of OCPs in sediments among the three types of rivers. The results showed that concentrations of Σ16OCPs in sediments from the three rivers followed the order urban river > reclamation-affected river > rural river, with a mean value of 247...
November 8, 2016: Environmental Science and Pollution Research International
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