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https://www.readbyqxmd.com/read/29203173/evaluation-of-the-dynamic-predictors-of-fluid-responsiveness-in-dogs-receiving-goal-directed-fluid-therapy
#1
Maja J Drozdzynska, Yu-Mei Chang, Giacomo Stanzani, Ludovic Pelligand
OBJECTIVES: Goal-directed fluid therapy (GDFT) based on pulse pressure variation (PPV) was used in anaesthetized dogs undergoing abdominal surgeries. The aims were 1) to evaluate the success rate of the PPV ≥13% in detecting fluid responsiveness [delta stroke volume (ΔSV) ≥10%]; 2) to assess the correlation between PPV, systolic pressure variation (SPV), Plethysmograph Variability Index (PVI) and central venous pressure (CVP) and 3) to establish the threshold value for the PVI that would predict a PPV value of ≥13% and indirectly discriminate responders from nonresponders to fluid therapy...
June 17, 2017: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29143247/using-circulating-tumor-cells-to-evaluate-the-efficacy-of-irreversible-electroporation-for-unresectasble-pancreatic-cancer
#2
Mao Lin, Mohammed Alnaggar, Shu-Zhen Liang, Jian Shi, Li-Zhi Niu, Ji-Bing Chen, Ke-Cheng Xu
We used circulating tumor cells (CTCs) as biomarkers to evaluate the efficacy of pre-irreversible electroporation (IRE) and post-IRE for unresectable pancreatic cancer (PC). Real-time qPCR was used to detect potential biomarker genes in CTCs, and magnetic-activated cell sorting (MACS) and fluorescence-activated cell sorting (FACS) were performed on 43 patients with PC who underwent IRE. Some patients experienced adverse reactions within 30 days of the operation, including arrhythmia (6.9%), intraoperative transient change of blood pressure (25...
November 15, 2017: Immunologic Research
https://www.readbyqxmd.com/read/29120588/association-between-serpinb2-gene-expression-by-real-time-pcr-in-respiratory-epithelial-cells-and-atopic-bronchial-asthma-severity
#3
Nissreen E ELBadawy, Randa S Abdel-Latif, Hoda A El-Hady
Atopic bronchial asthma is chronic respiratory diseases of high frequency and high morbidity and mortality especially in patients refractory to the ordinary medical management. This study aimed to investigate the association between Serpin family B Member 2 (SERPINB2) gene expression and bronchial asthma severity. A total of 127 adult patients with asthma were enrolled in this study. Allergic respiratory symptoms were assessed and patients were classified according to Global Initiative for Asthma (GINA) criteria...
January 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29119875/effects-of-positive-end-expiratory-pressure-on-intraoperative-core-temperature-in-patients-undergoing-posterior-spine-surgery-prospective-randomised-trial
#4
Hyungseok Seo, Je Do Son, Hyung-Chul Lee, Hyung-Min Oh, Chul-Woo Jung, Hee-Pyoung Park
Objective Positive end-expiratory pressure (PEEP) causes carotid baroreceptor unloading, which leads to thermoregulatory peripheral vasoconstriction. However, the effects of PEEP on intraoperative thermoregulation in the prone position remain unknown. Methods Thirty-seven patients undergoing spine surgery in the prone position were assigned at random to receive either 10 cmH2O PEEP (Group P) or no PEEP (Group Z). The primary endpoint was core temperature 180 minutes after intubation. Secondary endpoints were delta core temperature (difference in core temperature between 180 minutes and immediately after tracheal intubation), incidence of intraoperative hypothermia (core temperature of <36°C), and peripheral vasoconstriction-related data...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29113517/shock-index-and-delta-shock-index-are-superior-to-existing-maternal-early-warning-criteria-to-identify-postpartum-hemorrhage-and-need-for-intervention
#5
Jaden R Kohn, Gary A Dildy, Catherine S Eppes
OBJECTIVE: To determine whether shock index (SI) is superior to traditional vital signs in predicting postpartum hemorrhage and need for intervention. METHODS: Retrospective case-control study in an academic tertiary-care county hospital. Forty-one consecutive postpartum hemorrhage (PPH) cases and 41 controls were frequency-matched by mode of delivery and maternal weight. We measured four criteria: heart rate, systolic blood pressure (SBP), SI (HR/SBP), and delta-SI (peak SI - baseline SI)...
November 7, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29078329/entropy-and-optimality-in-river-deltas
#6
Alejandro Tejedor, Anthony Longjas, Douglas A Edmonds, Ilya Zaliapin, Tryphon T Georgiou, Andrea Rinaldo, Efi Foufoula-Georgiou
The form and function of river deltas is intricately linked to the evolving structure of their channel networks, which controls how effectively deltas are nourished with sediments and nutrients. Understanding the coevolution of deltaic channels and their flux organization is crucial for guiding maintenance strategies of these highly stressed systems from a range of anthropogenic activities. To date, however, a unified theory explaining how deltas self-organize to distribute water and sediment up to the shoreline remains elusive...
October 31, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29055075/association-between-genetic-polymorphisms-and-pain-sensitivity-in-patients-with-hip-osteoarthritis
#7
Anne E Olesen, Lecia M Nielsen, Søren Feddersen, Joachim Erlenwein, Frank Petzke, Michael Przemeck, Lona L Christrup, Asbjørn M Drewes
BACKGROUND: Factors such as age, gender and genetic polymorphisms may explain individual difference in pain phenotype. Genetic associations to pain sensitivity have previously been investigated in osteoarthritis patients with focus on the P2X7, TRPV1 and TACR1 genes. However, other genes may play a role as well. Osteoarthritis is a common joint disease and many patients suffering from this disease are thought to have increased sensitivity to noxious stimuli resulting from sensitization in the nociceptive system...
October 20, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29027074/uptake-of-radium-223-dichloride-and-early-18-f-naf-pet-response-are-driven-by-baseline-18-f-naf-parameters-a-pilot-study-in-castration-resistant-prostate-cancer-patients
#8
Arthur Letellier, Alison C Johnson, Nicolas How Kit, Jean-François Savigny, Alain Batalla, Jean-Jacques Parienti, Nicolas Aide
PURPOSE: The purpose of this study is to identify predictive factors on baseline [(18)F]NaF positron emission tomography (PET)/computed tomography (CT) of early response to radium-223 dichloride after 3 cycles of treatment in metastatic castration-resistant prostate cancer patients. PROCEDURES: Analysis of 152 metastases was performed in six consecutive patients who underwent [(18)F]NaF PET/CT at baseline and for early monitoring after 3 cycles of radium-223 dichloride...
October 12, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/28992453/fifs-a-data-mining-method-for-informative-marker-selection-in-high-dimensional-population-genomic-data
#9
Ioannis Kavakiotis, Patroklos Samaras, Alexandros Triantafyllidis, Ioannis Vlahavas
BACKGROUND AND OBJECTIVE: Single Nucleotide Polymorphism (SNPs) are, nowadays, becoming the marker of choice for biological analyses involving a wide range of applications with great medical, biological, economic and environmental interest. Classification tasks i.e. the assignment of individuals to groups of origin based on their (multi-locus) genotypes, are performed in many fields such as forensic investigations, discrimination between wild and/or farmed populations and others. Τhese tasks, should be performed with a small number of loci, for computational as well as biological reasons...
September 28, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/28989735/perception-of-global-image-contrast-involves-transparent-spatial-filtering-and-the-integration-and-suppression-of-local-contrasts-not-rms-contrast
#10
Tim S Meese, Daniel H Baker, Robert J Summers
When adjusting the contrast setting on a television set, we experience a perceptual change in the global image contrast. But how is that statistic computed? We addressed this using a contrast-matching task for checkerboard configurations of micro-patterns in which the contrasts and spatial spreads of two interdigitated components were controlled independently. When the patterns differed greatly in contrast, the higher contrast determined the perceived global contrast. Crucially, however, low contrast additions of one pattern to intermediate contrasts of the other caused a paradoxical reduction in the perceived global contrast...
September 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/28972120/fremanezumab-a-humanized-monoclonal-anti-cgrp-antibody-inhibits-thinly-myelinated-a%C3%AE-but-not-unmyelinated-c-meningeal-nociceptors
#11
Agustin Melo-Carrillo, Andrew M Strassman, Rony-Reuven Nir, Aaron J Schain, Rodrigo Noseda, Jennifer Stratton, Rami Burstein
Calcitonin gene-related peptide (CGRP), the most abundant neuropeptide in primary afferent sensory neurons, is strongly implicated in the pathophysiology of migraine headache, but its role in migraine is still equivocal. As a new approach to migraine treatment, humanized anti-CGRP monoclonal antibodies (CGRP-mAbs) were developed to reduce the availability of CGRP, and were found effective in reducing the frequency of chronic and episodic migraine. We recently tested the effect of fremanezumab (TEV-48125), a CGRP-mAb, on the activity of second-order trigeminovascular dorsal horn neurons that receive peripheral input from the cranial dura, and found a selective inhibition of high-threshold but not wide-dynamic range class of neurons...
November 1, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28947779/cortical-afferents-onto-the-nucleus-reticularis-thalami-promote-plasticity-of-low-threshold-excitability-through-glun2c-nmdars
#12
Laura M J Fernandez, Chiara Pellegrini, Gil Vantomme, Elidie Béard, Anita Lüthi, Simone Astori
Thalamus and cortex represent a highly integrated processing unit that elaborates sensory representations. Interposed between cortex and thalamus, the nucleus Reticularis thalami (nRt) receives strong cortical glutamatergic input and mediates top-down inhibitory feedback to thalamus. Despite growing appreciation that the nRt is integral for thalamocortical functions from sleep to attentional wakefulness, we still face considerable gaps in the synaptic bases for cortico-nRt communication and plastic regulation...
September 25, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28923731/phosphorus-sorption-desorption-and-effects-of-temperature-ph-and-salinity-on-phosphorus-sorption-in-marsh-soils-from-coastal-wetlands-with-different-flooding-conditions
#13
Junhong Bai, Xiaofei Ye, Jia Jia, Guangliang Zhang, Qingqing Zhao, Baoshan Cui, Xinhui Liu
Wetland soils act as a sink or source of phosphorus (P) to the overlaying water due to phosphorus sorption-desorption processes. Litter information is available on sorption and desorption behaviors of phosphorus in coastal wetlands with different flooding conditions. Laboratory experiments were conducted to investigate phosphorus sorption-desorption processes, fractions of adsorbed phosphorus, and the effects of salinity, pH and temperature on phosphorus sorption on soils in tidal-flooding wetlands (TW), freshwater-flooding wetlands (FW) and seasonal-flooding wetlands (SW) in the Yellow River Delta...
August 24, 2017: Chemosphere
https://www.readbyqxmd.com/read/28891783/cortical-local-field-potential-power-is-associated-with-behavioral-detection-of-near-threshold-stimuli-in-the-rat-whisker-system-dissociation-between-orbitofrontal-and-somatosensory-cortices
#14
Rachel E Rickard, Andrew M J Young, Todor V Gerdjikov
There is growing evidence that ongoing brain oscillations may represent a key regulator of attentional processes and as such may contribute to behavioral performance in psychophysical tasks. OFC appears to be involved in the top-down modulation of sensory processing; however, the specific contribution of ongoing OFC oscillations to perception has not been characterized. Here we used the rat whiskers as a model system to further characterize the relationship between cortical state and tactile detection. Head-fixed rats were trained to report the presence of a vibrotactile stimulus (frequency = 60 Hz, duration = 2 sec, deflection amplitude = 0...
September 11, 2017: Journal of Cognitive Neuroscience
https://www.readbyqxmd.com/read/28886556/developing-an-integrated-3d-hydrodynamic-and-emerging-contaminant-model-for-assessing-water-quality-in-a-yangtze-estuary-reservoir
#15
Cong Xu, Jingjie Zhang, Xiaowei Bi, Zheng Xu, Yiliang He, Karina Yew-Hoong Gin
An integrated 3D-hydrodynamic and emerging contaminant model was developed for better understanding of the fate and transport of emerging contaminants in Qingcaosha Reservoir. The reservoir, which supplies drinking water for nearly half of Shanghai's population, is located in Yangtze Delta. The integrated model was built by Delft3D suite, a fully integrated multidimensional modeling software. Atrazine and Bisphenol A (BPA) were selected as two representative emerging contaminants for the study in this reservoir...
August 23, 2017: Chemosphere
https://www.readbyqxmd.com/read/28877225/effect-of-water-based-recovery-on-blood-lactate-removal-after-high-intensity-exercise
#16
RANDOMIZED CONTROLLED TRIAL
Francesco Lucertini, Marco Gervasi, Giancarlo D'Amen, Davide Sisti, Marco Bruno Luigi Rocchi, Vilberto Stocchi, Piero Benelli
This study assessed the effectiveness of water immersion to the shoulders in enhancing blood lactate removal during active and passive recovery after short-duration high-intensity exercise. Seventeen cyclists underwent active water- and land-based recoveries and passive water and land-based recoveries. The recovery conditions lasted 31 minutes each and started after the identification of each cyclist's blood lactate accumulation peak, induced by a 30-second all-out sprint on a cycle ergometer. Active recoveries were performed on a cycle ergometer at 70% of the oxygen consumption corresponding to the lactate threshold (the control for the intensity was oxygen consumption), while passive recoveries were performed with subjects at rest and seated on the cycle ergometer...
2017: PloS One
https://www.readbyqxmd.com/read/28861499/even-high-doses-of-oral-cannabidol-do-not-cause-thc-like-effects-in-humans-comment-on-merrick-et-al-cannabis-and-cannabinoid-research-2016-1-1-102-112-doi-10-1089-can-2015-0004
#17
Franjo Grotenhermen, Ethan Russo, Antonio Waldo Zuardi
This short communication examines the question whether the experimental data presented in a study by Merrick et al. are of clinical relevance. These authors found that cannabidiol (CBD), a major cannabinoid of the cannabis plant devoid of psychotropic effects and of great interest for therapeutic use in several medical conditions, may be converted in gastric fluid into the psychoactive cannabinoids delta-8-THC and delta-9-THC to a relevant degree. They concluded that "the acidic environment during normal gastrointestinal transit can expose orally CBD-treated patients to levels of THC and other psychoactive cannabinoids that may exceed the threshold for a positive physiological response...
2017: Cannabis and Cannabinoid Research
https://www.readbyqxmd.com/read/28846545/physiologic-evaluation-of-coronary-lesions-using-instantaneous-wave-free-ratio-ifr-in-patients-with-severe-aortic-stenosis-undergoing-trans-catheter-aortic-valve-implantation
#18
Roberto Scarsini, Gabriele Pesarini, Carlo Zivelonghi, Anna Piccoli, Valeria Ferrero, Mattia Lunardi, Leonardo Gottin, Claudia Zanetti, Giuseppe Faggian, Flavio Ribichini
AIMS: We sought to assess eventual changes in iFR measurements in patients with aortic stenosis (AS) before and after TAVI in coronary lesions with different degree of angiographic severity. METHODS AND RESULTS: The functional relevance of 145 coronary lesions was assessed by on-line iFR and FFR measurement in 66 patients with severe AS before and after TAVI, during the same procedure. The iFR-FFR classification agreement was calculated for pre- and post-TAVI measurements...
August 29, 2017: EuroIntervention
https://www.readbyqxmd.com/read/28814801/strain-dependence-of-the-angelman-syndrome-phenotypes-in-ube3a-maternal-deficiency-mice
#19
Heather A Born, An T Dao, Amber T Levine, Wai Ling Lee, Natasha M Mehta, Shubhangi Mehra, Edwin J Weeber, Anne E Anderson
Angelman syndrome (AS) is a genetic neurodevelopmental disorder, most commonly caused by deletion or mutation of the maternal allele of the UBE3A gene, with behavioral phenotypes and seizures as key features. Currently no treatment is available, and therapeutics are often ineffective in controlling AS-associated seizures. Previous publications using the Ube3a maternal deletion model have shown behavioral and seizure susceptibility phenotypes, however findings have been variable and merit characterization of electroencephalographic (EEG) activity...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28811254/parsing-the-neural-signatures-of-reduced-error-detection-in-older-age
#20
Siobhán Harty, Peter R Murphy, Ian H Robertson, Redmond G O'Connell
Recent work has demonstrated that explicit error detection relies on a neural evidence accumulation process that can be traced in the human electroencephalogram (EEG). Here, we sought to establish the impact of natural aging on this process by recording EEG from young (18-35 years) and older adults (65-88 years) during the performance of a Go/No-Go paradigm in which participants were required to overtly signal their errors. Despite performing the task with equivalent accuracy, older adults reported substantially fewer errors, and the timing of their reports were both slower and more variable...
November 1, 2017: NeuroImage
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