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https://www.readbyqxmd.com/read/28722246/delta-9-tetrahydrocannabinol-decreases-masticatory-muscle-sensitization-in-female-rats-through-peripheral-cannabinoid-receptor-activation
#1
H Wong, S Hossain, B E Cairns
BACKGROUND: This study investigated whether intramuscular injection of delta-9-tetrahydrocannabinol (THC), by acting on peripheral cannabinoid (CB) receptors, could decrease nerve growth factor (NGF)-induced sensitization in female rat masseter muscle; a model which mimics the symptoms of myofascial temporomandibular disorders. METHODS: Immunohistochemistry was used to explore the peripheral expression of cannabinoid receptors in the masseter muscle while behavioural and electrophysiology experiments were employed to assess the functional effects of intramuscular injection of THC...
July 18, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28699350/analgesic-properties-of-opioid-nk1-multitarget-ligands-with-distinct-in-vitro-profiles-in-naive-and-chronic-constriction-injury-cci-mice
#2
Joanna Starnowska, Roberto Costante, Karel Guillemyn, Katarzyna Popiolek-Barczyk, Nga N Chung, Carole Lemieux, Attila Keresztes, Joost Van Duppen, Adriano Mollica, John M Streicher, Jozef Vanden Broeck, Peter W Schiller, Dirk Tourwé, Joanna Mika, Steven Ballet, Barbara Przewlocka
The lower efficacy of opioids in neuropathic pain may be due to the increased activity of pronociceptive systems such as substance P. We present evidence to support this hypothesis in this work from the spinal cord in a neuropathic pain model in mice. Biochemical analysis confirmed the elevated mRNA and protein level of pronociceptive substance P, the major endogenous ligand of the neurokinin-1 (NK1) receptor, in the lumbar spinal cord of chronic constriction injury (CCI)-mice. To improve opioid efficacy in neuropathic pain, novel compounds containing opioid agonist and neurokinin 1 (NK1) receptor antagonist pharmacophores were designed...
July 12, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28685341/assessment-of-the-potential-health-risks-of-heavy-metals-in-soils-in-a-coastal-industrial-region-of-the-yangtze-river-delta
#3
Bifeng Hu, Jiayu Wang, Bin Jin, Yan Li, Zhou Shi
Soil heavy metal contamination is a serious environmental problem. Human beings may be directly exposed to heavy metals in soils through the inhalation of soil particles, dermal contact, and oral ingestion, which can seriously threaten health. This study assesses the health risks associated with heavy metals in soils by determining the concentrations of eight heavy metals (Cr, Pb, Cd, Hg, As, Cu, Zn, and Ni) based on 2051 surface-soil samples collected from the southern Yangtze River Delta of China. The mean concentrations were higher than the corresponding background values in Zhejiang Province and China as a whole, indicating an accumulation of heavy metals...
July 7, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28664769/raised-compartment-pressures-are-frequently-observed-with-tibial-shaft-fractures-despite-the-absence-of-compartment-syndrome-a-prospective-cohort-study
#4
Kelvin Lor Kah Ho, Nicholas Yeoh Ching Sing, Khai Phang Wong, Andy Wee Teck Huat
PURPOSE: To measure the intracompartmental pressures surrounding tibial fractures not exhibiting any clinical evidence of compartment syndrome. Our hypothesis was that pressures often exceed the recommended threshold of fasciotomy despite the absence of compartment syndrome, and hence diagnosis based on pressure measurements alone is unreliable. METHODS: Thirteen consecutive patients with closed tibial shaft fractures without clinical suspicion of compartment syndrome, and who were planned for intramedullary nailing, were prospectively enrolled...
May 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28601605/rapid-focal-cooling-attenuates-cortical-seizures-in-a-primate-epilepsy-model
#5
Guoping Ren, Jiaqing Yan, Guoxian Tao, Yunmeng Gan, Donghong Li, Xi Yan, Yongjuan Fu, Leiming Wang, Weimin Wang, Zhiming Zhang, Feng Yue, Xiaofeng Yang
Rapid focal cooling is an attractive nondestructive strategy to control and possibly prevent focal seizures. However, the temperature threshold necessary to abort seizures in primates is still unknown. Here, we explored this issue in a primate epilepsy model and observed the effect of rapid cooling on different electroencephalogram frequency bands, aiming at providing necessary experimental data for future clinical translational studies and exploring the mechanism of focal cooling in terminating seizures. We induced focal neocortical seizures using microinjection of 4-aminopyridine into premotor cortex in five anesthetized cynomolgus monkeys...
June 7, 2017: Experimental Neurology
https://www.readbyqxmd.com/read/28585300/investigation-of-error-detection-capabilities-of-phantom-epid-and-mlc-log-file-based-imrt-qa-methods
#6
Dewayne L Defoor, Sotirios Stathakis, Joseph E Roring, Neil A Kirby, Panayiotis Mavroidis, Mohammad Obeidat, Nikos Papanikolaou
A patient specific quality assurance (QA) should detect errors that originate anywhere in the treatment planning process. However, the increasing complexity of treatment plans has increased the need for improvements in the accuracy of the patient specific pretreatment verification process. This has led to the utilization of higher resolution QA methods such as the electronic portal imaging device (EPID) as well as MLC log files and it is important to know the types of errors that can be detected with these methods...
June 6, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28579945/lfp-oscillations-in-the-mesencephalic-locomotor-region-during-voluntary-locomotion
#7
Brian R Noga, Francisco J Sanchez, Luz M Villamil, Christopher O'Toole, Stefan Kasicki, Maciej Olszewski, Anna M Cabaj, Henryk Majczyński, Urszula Sławińska, Larry M Jordan
Oscillatory rhythms in local field potentials (LFPs) are thought to coherently bind cooperating neuronal ensembles to produce behaviors, including locomotion. LFPs recorded from sites that trigger locomotion have been used as a basis for identification of appropriate targets for deep brain stimulation (DBS) to enhance locomotor recovery in patients with gait disorders. Theta band activity (6-12 Hz) is associated with locomotor activity in locomotion-inducing sites in the hypothalamus and in the hippocampus, but the LFPs that occur in the functionally defined mesencephalic locomotor region (MLR) during locomotion have not been determined...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28559462/expression-of-five-neuroblastoma-genes-in-bone-marrow-or-blood-of-patients-with-relapsed-refractory-neuroblastoma-provides-a-new-biomarker-for-disease-and-prognosis
#8
Araz Marachelian, Judith G Villablanca, Cathy W Y Liu, Betty Liu, Fariba Goodarzian, Hollie A Lai, Hiroyuki Shimada, Hung C Tran, Jaime A Parra, Richard Gallego, Nora Bedrossian, Sabrina Young, Scarlett Czarnecki, Rebekah Kennedy, Brian Weiss, Kelly C Goldsmith, Meaghan Granger, Katherine K Matthay, Susan Groshen, Shahab Asgharzadeh, Richard Sposto, Robert C Seeger
We determined if quantifying neuroblastoma (NB)-associated mRNAs (NB-mRNA) in bone marrow (BM) and blood improves assessment of disease and prediction of disease progression in patients with relapsed/refractory NB. <br /><br />Patients and Methods: mRNA for CHGA, DCX, DDC, PHOX2B, and TH was quantified in BM and blood from 101 patients concurrently with clinical disease evaluations. Correlation between NB-mRNA (delta cycle threshold [ΔCt] for the geometric mean of genes from the TaqMan® Low Density Array NB5 assay) and morphologically-defined tumor cell percentage in BM, (123)I-meta-iodobenzylguanidine (MIBG) Curie score, and CT/MRI-defined tumor longest diameter was determined...
May 30, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28535551/angiotensin-converting-enzyme-inhibitors-and-angiotensin-receptor-blockers-modulate-the-function-of-myelinated-fibers-after-chemotherapy-a-quantitative-sensory-testing-study
#9
Carlos J Roldan, Juhee Song, Mitchell P Engle, Patrick M Dougherty
BACKGROUND: Angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARB) have sufficient scientific support for their use as tissue protectors. Preliminary studies suggest that their angiotensin-II type 2 receptor (AT2R)-blocking properties have a beneficial profile in the treatment of neuropathic pain. OBJECTIVES: The purpose of the current study was to quantify the extent of the somatosensory effects of ACEI and ARB in cancer patients with chemotherapy-induced peripheral neuropathy...
May 2017: Pain Physician
https://www.readbyqxmd.com/read/28523004/selection-of-suitable-reference-genes-for-quantitative-real-time-pcr-in-sapium-sebiferum
#10
Xue Chen, Yingji Mao, Shengwei Huang, Jun Ni, Weili Lu, Jinyan Hou, Yuting Wang, Weiwei Zhao, Minghao Li, Qiaojian Wang, Lifang Wu
Chinese tallow (Sapium sebiferum L.) is a promising landscape and bioenergy plant. Measuring gene expression by quantitative real-time polymerase chain reaction (qRT-PCR) can provide valuable information on gene function. Stably expressed reference genes for normalization are a prerequisite for ensuring the accuracy of the target gene expression level among different samples. However, the reference genes in Chinese tallow have not been systematically validated. In this study, 12 candidate reference genes (18S, GAPDH, UBQ, RPS15, SAND, TIP41, 60S, ACT7, PDF2, APT, TBP, and TUB) were investigated with qRT-PCR in 18 samples, including those from different tissues, from plants treated with sucrose and cold stresses...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28466144/comparative-analysis-of-background-eeg-activity-in-childhood-absence-epilepsy-during-valproate-treatment-a-standardized-low-resolution-brain-electromagnetic-tomography-sloreta-study
#11
Jung-Hyun Shin, Tae-Hoon Eom, Young-Hoon Kim, Seung-Yun Chung, In-Goo Lee, Jung-Min Kim
Valproate (VPA) is an antiepileptic drug (AED) used for initial monotherapy in treating childhood absence epilepsy (CAE). EEG might be an alternative approach to explore the effects of AEDs on the central nervous system. We performed a comparative analysis of background EEG activity during VPA treatment by using standardized, low-resolution, brain electromagnetic tomography (sLORETA) to explore the effect of VPA in patients with CAE. In 17 children with CAE, non-parametric statistical analyses using sLORETA were performed to compare the current density distribution of four frequency bands (delta, theta, alpha, and beta) between the untreated and treated condition...
May 2, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/28454651/clinical-evaluation-of-the-abbott-realtime-mtb-assay-for-direct-detection-of-mycobacterium-tuberculosis-complex-from-respiratory-and-non-respiratory-samples
#12
Vladimira Hinić, Kinga Feuz, Selda Turan, Andrea Berini, Reno Frei, Karin Pfeifer, Daniel Goldenberger
Rapid and reliable diagnosis is crucial for correct management of tuberculosis. The Abbott RealTime MTB Assay represents a novel qualitative real-time PCR assay for direct detection of M. tuberculosis-complex (MTB) DNA from respiratory samples. The test targets two highly conserved sequences, the multi-copy insertion element IS6110 and the protein antigen B (PAB) gene of MTB, allowing even the detection of IS6610-deficient strains. We evaluated this commercial diagnostic test by analyzing 200 respiratory and, for the first time, 87 non-respiratory clinical specimens from our tertiary care institution and compared its results to our IS6110-based in-house real-time PCR for MTB as well as MTB culture...
May 2017: Tuberculosis
https://www.readbyqxmd.com/read/28342940/high-test-retest-reliability-of-pain-related-evoked-potentials-prep-in-healthy-subjects
#13
Özüm Simal Özgül, Christoph Maier, Elena K Enax-Krumova, Jan Vollert, Marc Fischer, Martin Tegenthoff, Oliver Höffken
Pain-related evoked potentials (PREP) is an established electrophysiological method to evaluate the signal transmission of electrically stimulated A-delta fibres. Although prerequisite for its clinical use, test-retest-reliability and side-to-side differences of bilateral stimulation in healthy subjects have not been examined yet. We performed PREP twice within 3-14days in 33 healthy subjects bilaterally by stimulating the dorsal hand. Detection (DT) and pain thresholds (PT) after electrical stimulation, the corresponding pain ratings, latencies of P0, N1, P1 and N2 components and the corresponding amplitudes were assessed...
March 22, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28323447/injury-mitigation-estimates-for-an-intersection-driver-assistance-system-in-straight-crossing-path-crashes-in-the-united-states
#14
John M Scanlon, Rini Sherony, Hampton C Gabler
OBJECTIVE: Accounting for one fifth of all crashes and one sixth of all fatal crashes in the United States, intersection crashes are among the most frequent and fatal crash modes. Intersection advanced driver assistance systems (I-ADAS) are emerging vehicle-based active safety systems that aim to help drivers safely navigate intersections. The objective of this study was to estimate the number of crashes and number of vehicles with a seriously injured driver (Maximum Abbreviated Injury Scale [MAIS] 3+) that could be prevented or reduced if, for every straight crossing path (SCP) intersection crash, one of the vehicles had been equipped with an I-ADAS...
May 29, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28267532/r2-relaxometry-of-the-pancreas-in-patients-with-human-hemochromatosis-protein-associated-hereditary-hemochromatosis
#15
B Henninger, S Rauch, H Zoller, M Plaikner, W Jaschke, C Kremser
PURPOSE: To evaluate pancreatic iron in patients with human hemochromatosis protein associated hereditary hemochromatosis (HHC) using R2* relaxometry. MATERIALS AND METHODS: 81 patients (58 male, 23 female; median age 49.5, range 10-81 years) with HHC were retrospectively studied. All underwent 1.5T magnetic resonance imaging (MRI) of the abdomen. A fat-saturated multi-gradient echo sequence with 12 echoes (TR=200ms; TE-initial 0.99ms; Delta-TE 1.41ms; 12 echoes; flip-angle: 20°) was used for the R2* quantification of the liver and the pancreas...
April 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28265243/altered-intermittent-rhythmic-delta-and-theta-activity-in-the-electroencephalographies-of-high-functioning-adult-patients-with-autism-spectrum-disorder
#16
Dominique Endres, Simon Maier, Bernd Feige, Nicole A Posielski, Kathrin Nickel, Dieter Ebert, Andreas Riedel, Alexandra Philipsen, Evgeniy Perlov, Ludger Tebartz van Elst
Background: Autism spectrum disorder (ASD) is often associated with epilepsy. Previous studies have also shown increased rates of electroencephalographic (EEG) alteration in ASD patients without epilepsy. The aim of this study was to compare the rate of intermittent rhythmic delta and theta activity (IRDA/IRTA) events between high-functioning adult patients with ASD and matched healthy controls. Materials and Methods: Routine EEG records of 19 ASD patients and 19 matched controls were screened for IRDA/IRTA using a fully data driven analysis with fixed thresholds...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28251078/vasoactive-intestinal-peptide-a-promising-agent-for-myopia
#17
Ayse Idil Cakmak, Hikmet Basmak, Huseyin Gursoy, Mete Ozkurt, Nilgun Yildirim, Nilufer Erkasap, Mustafa Deger Bilgec, Nese Tuncel, Ertugrul Colak
AIM: To investigate the role of vasoactive intestinal peptide (VIP) in form-deprivation myopia (FDM). METHODS: FDM was created in three groups of eight chicks by placing a translucent diffuser on their right eyes. Intravitreal injections of saline and VIP were applied once a day into the occluded eyes of groups 2 and 3, respectively. Retinoscopy and axial length (AL) measurements were performed on the first and 8(th) days of diffuser wear. The retina mRNA levels of the VIP receptors and the ZENK protein in right eyes of the three groups and left eyes of the first group on day 8 were determined using real time polymerase chain reaction (PCR)...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28250407/mechanical-stimulus-induced-wthdrawal-behavior-increases-subsequent-pre-stimulus-local-field-potential-power-in-the-rostral-anterior-cingulate-cortex-in-unanesthetized-rats
#18
Zui Shen, Jing Sun, Boyi Liu, Yongliang Jiang, Yuanyuan Wu, Jialing Wang, Xiaomei Shao, Jianqiao Fang
BACKGROUND The rostral anterior cingulate cortex (rACC) is important in pain expectation. Previous studies demonstrated that mechanical stimulus-induced withdrawal behaviors are spinally-mediated nocifensive reflexes in rats, but it is not known whether pain expectation is influenced by withdrawal behaviors. MATERIAL AND METHODS We reanalyzed previous mechanosensitivity measurements of 244 rats measured 5 times in succession. To study neural oscillation in the rACC, 1 recording microwire array was surgically implanted...
March 2, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28230056/threshold-of-long-term-survival-of-a-coastal-delphinid-in-anthropogenically-degraded-environment-indo-pacific-humpback-dolphins-in-pearl-river-delta
#19
Leszek Karczmarski, Shiang-Lin Huang, Stephen C Y Chan
Defining demographic and ecological threshold of population persistence can assist in informing conservation management. We undertook such analyses for the Indo-Pacific humpback dolphin (Sousa chinensis) in the Pearl River Delta (PRD) region, southeast China. We use adult survival estimates for assessments of population status and annual rate of change. Our estimates indicate that, given a stationary population structure and minimal risk scenario, ~2000 individuals (minimum viable population in carrying capacity, MVPk) can maintain the population persistence across 40 generations...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28226029/predictive-value-of-c-reactive-protein-in-critically-ill-patients-after-abdominal-surgery
#20
Frédéric Sapin, Patrick Biston, Michael Piagnerelli
OBJECTIVES: The development of sepsis after abdominal surgery is associated with high morbidity and mortality. Due to inflammation, it may be difficult to diagnose infection when it occurs, but measurement of C-reactive protein could facilitate this diagnosis. In the present study, we evaluated the predictive value and time course of C-reactive protein in relation to outcome in patients admitted to the intensive care unit (ICU) after abdominal surgery. METHODS: We included patients admitted to the ICU after abdominal surgery over a period of two years...
January 1, 2017: Clinics
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