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Delta threshold

Shehla Akbar, Fazal Subhan, Nasiara Karim, Muhammad Shahid, Nisar Ahmad, Gowhar Ali, Wajahat Mahmood, Khwaja Fawad
BACKGROUND: Diabetic neuropathy is the most prevalent, persistent and debilitating complication of diabetes mellitus often coupled with vulvodynia that may present as an isolated symptom or as a part of constellation of other neuropathic abnormalities. OBJECTIVE: Flavonoids have selective affinity for GABA receptors and 6-methoxyflavanone (6-MeOF) is a positive allosteric modulator of GABA responses at human recombinant GABAA receptors. GABAergic and opioidergic system inhibition have been shown to facilitate neuropathic pain...
October 17, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Rohit Marawar, Hsiang J Yeh, Chris Carnabatu, John M Stern
INTRODUCTION: The EEG rhythms demonstrate changes in frequency and power with spontaneous changes in behavioral state that do not have well understood metabolic correlates within the brain. To investigate this question and compare the temporal lobe theta and delta rhythms, resting-state functional MRI (fMRI) was obtained with simultaneous EEG. METHODS: Simultaneous EEG-fMRI was recorded from 14 healthy, sleep-deprived subjects in awake and drowsy states. Scalp electrodes corresponding to bilateral temporal lobes were used to calculate delta and theta band power...
October 18, 2016: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
Ha Young Park, Hyung Joo Oh, Ki-Hyun Kim, Tae-Ok Kim, Cheol-Kyu Park, Hong-Jun Shin, Jung-Hwan Lim, Yong-Soo Kwon, In-Jae Oh, Yu-Il Kim, Sung-Chul Lim, Young-Chul Kim, Yoo-Duk Choi
BACKGROUND: Epidermal growth factor receptor (EGFR) gene mutation is a reliable predictive factor for response to EGFR-tyrosine kinase inhibitors (TKIs). The quantified EGFR value may also predict response and survival within an EGFR mutated group. METHODS: We conducted a retrospective study of 836 lung cancer patients. The patient sample was divided into two groups based on the mean delta cycle threshold (∆Ct) value. EGFR mutation tests using peptide nucleic acid (PNA)-mediated clamping polymerase chain reaction (PCR) were performed...
September 1, 2016: Thoracic Cancer
Di Liu, Chao Zhao, Hailin Wang
The detection of 5-hydroxymethylcytosine (5hmC), a newly recognized epigenetic mark, is essential to its functional study. Here, an efficient and simple two-step-amplification method to detect 5hmC mediated by glucosylation is reported, which combines rolling circle amplification (RCA) and a quantitative polymerase chain reaction (qPCR). In the first step RCA, the glucosylated 5hmC (5ghmC), but not 5hmC, 5-methylcytosine (5mC) or cytosine (C) bases, could directly and specifically inhibit the activity of phi29 DNA polymerase, resulting in less RCA product compared to that using C-/5mC-/5hmC-containing templates...
2016: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
Andrea Schlegel, Michael Linecker, Philipp Kron, Georg Györi, Michelle L De Oliveira, Beat Müllhaupt, Pierre-Alain Clavien, Philipp Dutkowski
Allocation of liver grafts triggers emotional debates, as those patients, not receiving an organ, are prone to death. We analyzed a high MELD cohort (lab MELD≥30, n=100, median lab MELD of 35 (IQR: 31-37) of liver transplant recipients at our center over the last ten years, and compared results with a low MELD group, matched by propensity scoring for donor age, recipient age and cold ischemia. Endpoints of our study were cumulative post-transplant morbidity, cost, and survival. Six different prediction models, including D-MELD, Delta MELD, DRI, SOFT, BAR, and UCLA-FRS, were applied in both cohorts to identify risk for poor outcome and high cost...
September 27, 2016: American Journal of Transplantation
Lisa K B Holper, Alekandra Aleksandrowicz, Mario Müller, Vladeta Ajdacic-Gross, Helene Haker, Andreas J Fallgatter, Florence Hagenmuller, Wolfram Kawohl, Wulf Rössler
A psychosis phenotype can be observed below the threshold of clinical detection. The study aimed to investigate whether subclinical psychotic symptoms are associated with deficits in controlling emotional interference, and whether cortical brain and cardiac correlates of these deficits can be detected using functional near-infrared spectroscopy (fNIRS). A data set derived from a community sample was obtained from the Zurich Program for Sustainable Development of Mental Health Services. 174 subjects (mean age 29...
2016: Frontiers in Behavioral Neuroscience
A Pawlowski, M Beschi, J L Guzmán, A Visioli, M Berenguel, S Dormido
In this work, an application of the Symmetric Send-On-Delta (SSOD) event-based controllers to the inside air temperature control of the greenhouse production process is presented. The control technique analysis is split into two stages. The first stage is devoted to determine the proper controller parameters and to check the influence of the Send-On-Delta (SOD) threshold value through simulation study. At the second stage, experimental tests on the real greenhouse facilities are performed. The obtained results show that the analyzed control techniques handle the control task with desired accuracy and performance...
September 1, 2016: ISA Transactions
Shubhada Shenai, Katharina Ronacher, Stefanus Malherbe, Kim Stanley, Magdalena Kriel, Jill Winter, Thomas Peppard, Charles E Barry, Jing Wang, Lori E Dodd, Laura E Via, Clifton E Barry, Gerhard Walzl, David Alland
INTRODUCTION: Biomarkers are needed to monitor tuberculosis (TB) treatment and predict treatment outcomes. We evaluated the Xpert MTB/RIF (Xpert) assay as a biomarker for TB treatment during and at the end of the 24 weeks therapy. METHODS: Sputum from 108 HIV-negative, culture-positive pulmonary TB patients was analyzed using Xpert at time points before and during anti-TB therapy. Results were compared against culture. Direct Xpert cycle-threshold (Ct), a change in the Ct (delta Ct), or a novel "percent closing of baseline Ct deficit" (percent closing) were evaluated as classifiers of same-day and end-of-treatment culture and therapeutic outcomes...
2016: PloS One
Iñaki Cormenzana Méndez, Andrés Martín, Teaire L Charmichael, Mellina M Jacob, Eliza M C B Lacerda, Bruno D Gomes, Malinda E C Fitzgerald, Dora F Ventura, Luiz C L Silveira, Beatriz M O'Donell, Givago S Souza
Pseudoisochromatic stimuli have been widely used to evaluate color discrimination and to identify color vision deficits. Luminance noise is one of the stimulus parameters used to ensure that subject's response is due to their ability to discriminate target stimulus from the background based solely on the hue between the colors that compose such stimuli. We studied the influence of contrast modulation of the stimulus luminance noise on threshold and reaction time color discrimination. We evaluated color discrimination thresholds using the Cambridge Color Test (CCT) at six different stimulus mean luminances...
2016: Frontiers in Psychology
Jian Shi, Yuan Li, Shuzhen Liang, Jianying Zeng, Guifeng Liu, Feng Mu, Haibo Li, Jibing Chen, Tongjun Liu, Lizhi Niu
In this study, we determined the number of peripheral blood circulating tumor cells (CTCs) pre- and post-cryosurgery in patients with colorectal cancer liver metastasis as a reference for understanding the relevance of any changes to the efficacy of cryosurgery. CTC numbers and CTC-related gene expression were measured in the peripheral blood of 55 patients with colorectal liver metastasis at 1 day before and 7 and 30 d after cryoablation using magnetic activated cell sorting (MACS) and fluorescence activated cell sorting (FACS) combined with real-time quantitative PCR (RT-qPCR)...
September 2016: Cancer Biology & Therapy
Xiaoyu Yang, Yi Xu, Amanda Brooks, Bin Guo, Keith W Miskimins, Steven Y Qian
Recent research has demonstrated that colon cancer cell proliferation can be suppressed in the cells that overexpress COX-2 via generating 8-hydroxyoctanoic acid (a free radical byproduct) during dihomo-γ-linolenic acid (DGLA, an ω-6 fatty acid) peroxidation from knocking down cellular delta-5-desaturase (D5D, the key enzyme for converting DGLA to the downstream ω-6, arachidonic acid). Here, this novel research finding is extended to pancreatic cancer growth, as COX-2 is also commonly overexpressed in pancreatic cancer...
August 2016: Free Radical Biology & Medicine
Gabriel Gagnon-Turcotte, Yoan LeChasseur, Cyril Bories, Younes Messaddeq, Yves De Koninck, Benoit Gosselin
This paper presents a wireless headstage with real-time spike detection and data compression for combined optogenetics and multichannel electrophysiological recording. The proposed headstage, which is intended to perform both optical stimulation and electrophysiological recordings simultaneously in freely moving transgenic rodents, is entirely built with commercial off-the-shelf components, and includes 32 recording channels and 32 optical stimulation channels. It can detect, compress and transmit full action potential waveforms over 32 channels in parallel and in real time using an embedded digital signal processor based on a low-power field programmable gate array and a Microblaze microprocessor softcore...
June 20, 2016: IEEE Transactions on Biomedical Circuits and Systems
Hua Yin, Yanlin Ma, Yang Deng, Zhenbo Xu, Junyan Liu, Junfeng Zhao, Jianjun Dong, Junhong Yu, Zongming Chang
Genome shuffling is an efficient and promising approach for the rapid improvement of microbial phenotypes. In this study, genome shuffling was applied to enhance the yield of glutathione produced by Saccharomyces cerevisiae YS86. Six isolates with subtle improvements in glutathione yield were obtained from populations generated by ultraviolet (UV) irradiation and nitrosoguanidine (NTG) mutagenesis. These yeast strains were then subjected to recursive pool-wise protoplast fusion. A strain library that was likely to yield positive colonies was created by fusing the lethal protoplasts obtained from both UV irradiation and heat treatments...
August 2016: Journal of Microbiological Methods
J Patrick Reilly
This paper evaluates results of a survey of electrostimulation models of myelinated nerve. Participants were asked to determine thresholds of excitation for 18 cases involving different characteristics of the neuron, the stimulation waveform, and the electrode arrangement. Responses were received from 7 investigators using 10 models. Excitation thresholds differed significantly among these models. For example, with a 2 ms monophasic stimulus pulse and an electrode/fiber distance of 1 cm, thresholds from the least to greatest value differed by a factor of 8...
June 21, 2016: Physics in Medicine and Biology
Junhong Bai, Jia Jia, Guangliang Zhang, Qingqing Zhao, Qiongqiong Lu, Baoshan Cui, Xinhui Liu
Sediment samples were collected to a depth of 60 cm along a 350-m sampling belt in a short-term-flooding riparian wetland in the Yellow River Delta of China in three sampling seasons. Contents of heavy metals were determined to investigate their spatial and temporal distributions, sources and ecotoxities. Our results showed that As contents in the top 20 cm sediments increased before decreasing along the sampling belt in summer, whereas they kept stable before increasing in fall and spring. Cd contents increased along the sampling belt in three sampling seasons, whereas Ni and Cr generally exhibited a decreasing tendency...
May 18, 2016: Environmental Pollution
Toshikazu Kuniya, Hideki Sano
BACKGROUND: In mathematical epidemiology, age-structured epidemic models have usually been formulated as the boundary-value problems of the partial differential equations. On the other hand, in engineering, the backstepping method has recently been developed and widely studied by many authors. METHODS: Using the backstepping method, we obtained a boundary feedback control which plays the role of the threshold criteria for the prediction of increase or decrease of newly infected population...
2016: Theoretical Biology & Medical Modelling
W Wood, J Gore, A Catchot, D Cook, D Dodds, L J Krutz
The tarnished plant bug, Lygus lineolaris (Palisot de Beauvois), is a major pest of cotton in the midsouthern United States, including the states of Arkansas, Mississippi, Louisiana, western Tennessee, and southeastern Missouri. Insecticides provide the primary form of control for this pest, and numerous applications are required annually to control the tarnished plant bug. Little information exists regarding when to terminate insecticide applications targeting tarnished plant bugs in cotton. Numerous sprays are made late in the season to protect a small percentage of the overall yield...
April 22, 2016: Journal of Economic Entomology
Yi Xu, Xiaoyu Yang, Pinjing Zhao, Zhongyu Yang, Changhui Yan, Bin Guo, Steven Y Qian
Cyclooxygenase (COX), commonly overexpressed in cancer cells, is a major lipid peroxidizing enzyme that metabolizes polyunsaturated fatty acids (ω-3s and ω-6s). The COX-catalyzed free radical peroxidation of arachidonic acid (ω-6) can produce deleterious metabolites (e.g. 2-series prostaglandins) that are implicated in cancer development. Thus, COX inhibition has been intensively investigated as a complementary therapeutic strategy for cancer. However, our previous study has demonstrated that a free radical-derived byproduct (8-hydroxyoctanoic acid) formed from COX-catalyzed peroxidation of dihomo-γ-linolenic acid (DGLA, the precursor of arachidonic acid) can inhibit colon cancer cell growth...
July 2016: Free Radical Biology & Medicine
Carla Piano, Edoardo Mazzucchi, Anna Rita Bentivoglio, Anna Losurdo, Giovanna Calandra Buonaura, Claudio Imperatori, Pietro Cortelli, Giacomo Della Marca
The aim of the study was to evaluate the EEG modifications in patients with Huntington disease (HD) compared with controls, by means of the exact LOw REsolution Tomography (eLORETA) software. We evaluated EEG changes during wake, non-rapid eye movement (NREM) and rapid eye movement (REM) sleep. Moreover, we reviewed the literature concerning EEG modifications in HD. Twenty-three consecutive adult patients affected by HD were enrolled, 14 women and 9 men, mean age was 57.0 ± 12.4 years. Control subjects were healthy volunteers (mean age 58...
April 19, 2016: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
Lars Riecke
Recent studies have shown that perceptual detection of near-threshold auditory events may depend on the relative timing of the event and ongoing brain oscillations. Furthermore, transcranial alternating current stimulation (tACS), a non-invasive and silent brain stimulation technique, can entrain cortical alpha oscillations and thereby provide some experimental control over their timing. The present research investigates the potential of delta/theta-tACS to modulate hearing and auditory scene analysis. Detection of near-threshold auditory stimuli, which are modulated at 4 Hz and presented at various moments (phase lags) during ongoing tACS (two synchronous 4-Hz alternating currents applied transcranially to the two cerebral hemispheres), is measured in silence or in a masker...
2016: Advances in Experimental Medicine and Biology
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