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https://www.readbyqxmd.com/read/29666960/consciousness-indexing-and-outcome-prediction-with-resting-state-eeg-in-severe-disorders-of-consciousness
#1
Sabina Stefan, Barbara Schorr, Alex Lopez-Rolon, Iris-Tatjana Kolassa, Jonathan P Shock, Martin Rosenfelder, Suzette Heck, Andreas Bender
We applied the following methods to resting-state EEG data from patients with disorders of consciousness (DOC) for consciousness indexing and outcome prediction: microstates, entropy (i.e. approximate, permutation), power in alpha and delta frequency bands, and connectivity (i.e. weighted symbolic mutual information, symbolic transfer entropy, complex network analysis). Patients with unresponsive wakefulness syndrome (UWS) and patients in a minimally conscious state (MCS) were classified into these two categories by fitting and testing a generalised linear model...
April 17, 2018: Brain Topography
https://www.readbyqxmd.com/read/29642623/heavy-metal-pollution-delineation-based-on-uncertainty-in-a-coastal-industrial-city-in-the-yangtze-river-delta-china
#2
Bifeng Hu, Ruiying Zhao, Songchao Chen, Yue Zhou, Bin Jin, Yan Li, Zhou Shi
Assessing heavy metal pollution and delineating pollution are the bases for evaluating pollution and determining a cost-effective remediation plan. Most existing studies are based on the spatial distribution of pollutants but ignore related uncertainty. In this study, eight heavy-metal concentrations (Cr, Pb, Cd, Hg, Zn, Cu, Ni, and Zn) were collected at 1040 sampling sites in a coastal industrial city in the Yangtze River Delta, China. The single pollution index (PI) and Nemerow integrated pollution index (NIPI) were calculated for every surface sample (0-20 cm) to assess the degree of heavy metal pollution...
April 10, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29618823/oxygen-extraction-ratio-oer-as-a-measurement-of-hemodialysis-hd-induced-tissue-hypoxia-a-pilot-study
#3
Silverio Rotondi, Lida Tartaglione, Maria Luisa Muci, Alessio Farcomeni, Marzia Pasquali, Sandro Mazzaferro
HD tissue hypoxia associates with organ dysfunctions. OER, the ratio between SaO2 and central-venous-oxygen-saturation, could estimate oxygen requirements during sessions, but no data are available. We evaluated OER behavior in 20 HD patients with permanent central venous catheter (CVC) as vascular access. Pre-HD OER (33.6 ± 1.4%; M ± SE) was higher than normal (range 20-30%). HD sessions increased OER to 39.2 ± 1.5% (M ± SE; p < 0.05) by 30' and to 47.4 ± 1.5% (M ± SE; p < 0...
April 4, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29577341/impact-of-intraoperative-mechanical-ventilation-on-left-ventricular-lead-function-in-cardiac-resynchronization-therapy
#4
Christian von Bary, Viktoria Laski, Hannes Fricke, Florian Linhardt, Christopher Reithmann, Michael Fiek
BACKGROUND: Intraoperative controlled mechanical ventilation (CMV) changes the intra-thoracic geometry and may impact postoperative left ventricular (LV) lead function after CRT implantation. This multicenter study investigates the effect of intraoperative ventilation setting (spontaneous breathing = SB vs. CMV) on postoperative LV lead function taking into account patients body mass index (BMI). METHODS: CRT implantation was performed at two centres during SB in 92 and during CMV in 73 patients...
March 25, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29544242/satellite-based-estimates-of-daily-no2-exposure-in-china-using-hybrid-random-forest-and-spatiotemporal-kriging-model
#5
Yu Zhan, Yuzhou Luo, Xunfei Deng, Kaishan Zhang, Minghua Zhang, Michael L Grieneisen, Baofeng Di
A novel model named random-forest-spatiotemporal-kriging (RF-STK) was developed to estimate the daily ambient NO2 concentrations across China during 2013-2016 based on the satellite retrievals and geographic covariates. The RF-STK model showed good prediction performance, with cross-validation R2=0.62 (RMSE=13.3 µg/m3) for daily and R2=0.73 (RMSE=6.5 µg/m3) for spatial predictions. The nationwide population-weighted multiyear average of NO2 was predicted to be 30.9±11.7 µg/m3 (mean±standard deviation), with a slowly but significantly decreasing trend at a rate of -0...
March 16, 2018: Environmental Science & Technology
https://www.readbyqxmd.com/read/29538699/assessing-the-uncertainty-in-a-normal-tissue-complication-probability-difference-%C3%A2-ntcp-radiation-induced-liver-disease-rild-in-liver-tumour-patients-treated-with-proton-vs-x-ray-therapy
#6
Keiji Kobashi, Anussara Prayongrat, Takuya Kimoto, Chie Toramatsu, Yasuhiro Dekura, Norio Katoh, Shinichi Shimizu, Yoichi M Ito, Hiroki Shirato
Modern radiotherapy technologies such as proton beam therapy (PBT) permit dose escalation to the tumour and minimize unnecessary doses to normal tissues. To achieve appropriate patient selection for PBT, a normal tissue complication probability (NTCP) model can be applied to estimate the risk of treatment-related toxicity relative to X-ray therapy (XRT). A methodology for estimating the difference in NTCP (∆NTCP), including its uncertainty as a function of dose to normal tissue, is described in this study using the Delta method, a statistical method for evaluating the variance of functions, considering the variance-covariance matrix...
March 12, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/29492485/evidence-of-transboundary-mercury-and-other-pollutants-in-the-puyango-tumbes-river-basin-ecuador-peru
#7
Bruce G Marshall, Marcello M Veiga, Robert J Kaplan, Rebecca Adler Miserendino, Gary Schudel, Bridget A Bergquist, Jean R D Guimarães, Luis G S Sobral, Carolina Gonzalez-Mueller
In Portovelo in southern Ecuador, 87 gold processing centers along the Puyango-Tumbes River produce an estimated 6 tonnes of gold per annum using a combination of mercury amalgamation and/or cyanidation and processing poly-metallic ores. We analysed total Hg, Hg isotopes, total arsenic, cadmium, copper, lead and zinc in water and sediment along the Puyango in 2012-2014. The highest total mercury (THg) concentrations in sediments were found within a 40 km stretch downriver from the processing plants, with levels varying between 0...
March 1, 2018: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/29480363/ultrasound-plus-low-level-laser-therapy-for-knee-osteoarthritis-rehabilitation-a-randomized-placebo-controlled-trial
#8
Fernanda Rossi Paolillo, Alessandra Rossi Paolillo, Jessica Patrícia João, Daniele Frascá, Marcelo Duchêne, Herbert Alexandre João, Vanderlei Salvador Bagnato
This study evaluated the synergistic effects of ultrasound (US) and low-level laser therapy (LLLT) with or without therapeutic exercises (TE) in women with knee osteoarthritis. Forty-two Caucasian women with knee osteoarthritis were allocated into three groups: (1) the placebo group who did not perform TE, but the prototype without emitting light or ultrasonic waves was applied, (2) the US + LLLT group in which only the prototype was applied and (3) the TE + US + LLLT group that performed TE before the prototype was applied...
February 26, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29460241/ecological-and-human-health-risks-arising-from-exposure-to-metals-in-urban-soils-under-different-land-use-in-nigeria
#9
Chukwujindu M A Iwegbue, Bice S Martincigh
The concentrations of eight metals (Cd, Pb, Cr, Ni, Cu, Mn, Zn and Fe) were measured in soils under different land use in an urban environment of the Niger Delta in Nigeria. The aim was to provide information on the potential ecological and human health risks associated with human exposure to metals in these soils. The potential ecological risk due to metals in soils of these land use types falls in the range of low to moderate ecological risk with a significant contribution from Cd. The severity of the individual metals to ecological risk in these land use types followed the order Cd > Pb > Zn > Cu > Ni > Cr > Mn...
February 19, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29423022/comprehensive-analysis-of-gene-expression-and-dna-methylation-datasets-identify-valuable-biomarkers-for-rheumatoid-arthritis-progression
#10
Gang Fang, Qing Huai Zhang, Qianqian Tang, Zuling Jiang, Shasha Xing, Jianying Li, Yuzhou Pang
Rheumatoid arthritis (RA) represents a common systemic autoimmune disease which lays chronic and persistent pain on patients. The purpose of our study is to identify novel RA-related genes and biological processes/pathways. All the datasets of this study, including gene expression and DNA methylation datasets of RA and OA samples, were obtained from the free available database, i.e. Gene Expression Omnibus (GEO). We firstly identified the differentially expressed genes (DEGs) between RA and OA samples through the limma package of R programming software followed by the functional enrichment analysis in the Database for Annotation, Visualization and Integrated Discovery (DAVID) for the exploring of potential involved biological processes/pathways of DEGs...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29419558/monitoring-the-relationship-between-changes-in-cerebral-oxygenation-and-electroencephalography-patterns-during-cardiopulmonary-resuscitation-a-feasibility-study
#11
Elizabeth M Reagan, Robert T Nguyen, Shreyas T Ravishankar, Vikram Chabra, Barbara Fuentes, Rebecca Spiegel, Sam Parnia
OBJECTIVES: To date, no studies have examined real-time electroencephalography and cerebral oximetry monitoring during cardiopulmonary resuscitation as markers of the magnitude of global ischemia. We therefore sought to assess the feasibility of combining cerebral oximetry and electroencephalography in patients undergoing cardiopulmonary resuscitation and further to evaluate the electroencephalography patterns during cardiopulmonary resuscitation and their relationship with cerebral oxygenation as measured by cerebral oximetry...
February 6, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29357497/temporal-characteristics-of-exercise-induced-diaphragmatic-fatigue
#12
Bruno Archiza, Joseph F Welch, Caitlin M Geary, Grayson P Allen, Audrey Borghi-Silva, A William Sheel
There is evidence suggesting diaphragmatic fatigue (DF) occurs relatively early during high-intensity exercise; however, studies investigating the temporal characteristics of exercise-induced DF are limited by incongruent methodology. Eight healthy adult males (25 ± 5 yr) performed a maximal incremental exercise test on a cycle ergometer on day 1. A constant-load time-to-exhaustion (TTE) exercise test was conducted on day 2 at 60% delta between the calculated gas exchange threshold and peak work rate. Two additional constant-load exercise tests were performed at the same intensity on days 3 and 4 in a random order to either 50 or 75% TTE...
April 1, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29355786/upregulation-of-calcium-channel-alpha-2-delta-1-subunit-in-dorsal-horn-contributes-to-spinal-cord-injury-induced-tactile-allodynia
#13
Kazuki Kusuyama, Toshiya Tachibana, Hiroki Yamanaka, Masamichi Okubo, Shinichi Yoshiya, Koichi Noguchi
BACKGROUND CONTEXT: Spinal cord injury (SCI) commonly results not only in motor paralysis but also in the emergence of neuropathic pain (NeuP), both of which can impair the quality of life for patients with SCI. In the clinical field, it is well known that pregabalin, which binds to the voltage-gated calcium channel alpha-2-delta-1 (α2 δ-1) subunit has therapeutic effects on NeuP after SCI. A previous study has demonstrated that SCI increased α2 δ-1 in the L4-L6 dorsal spinal cord of SCI rats by Western blot analysis and that the increase of α2 δ-1 was correlated with tactile allodynia of the hind paw...
January 31, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29301050/field-detection-of-drugs-of-abuse-in-oral-fluid-using-the-alere%C3%A2-dds%C3%A2-2-mobile-test-system-with-confirmation-by-liquid-chromatography-tandem-mass-spectrometry-lc-ms-ms
#14
Alex J Krotulski, Amanda L A Mohr, Melissa Friscia, Barry K Logan
The collection and analysis of drugs in oral fluid (OF) at the roadside has become more feasible with the introduction of portable testing devices such as the Alere™ DDS®2 Mobile Test System (DDS®2). The objective of this study was to compare the on-site results for the DDS®2 to laboratory-based confirmatory assays with respect to detection of drugs of abuse in human subjects. As part of a larger Institutional Review Board approved study, two OF samples were collected from each participant at a music festival in Miami, FL, USA...
April 1, 2018: Journal of Analytical Toxicology
https://www.readbyqxmd.com/read/29280926/critical-illness-related-corticosteroid-insufficiency-in-cardiogenic-shock-patients-prevalence-and-prognostic-role
#15
Nicolas Ducrocq, Pascal Biferi, Nicolas Girerd, Ichraq Latar, Simon Lemoine, Pierre Perez, Carine Thivilier, Bruno Levy, Antoine Kimmoun
BACKGROUND: Cardiogenic shock shares with septic shock common hemodynamic features, inflammatory patterns and most likely similar complications such as critical illness-related corticosteroid insufficiency. The aim of this study was to evaluate the prevalence of critical illness-related corticosteroid insufficiency in cardiogenic shock patients and to secondarily assess its prognostic value on 90-day mortality. METHODS: A single-centre prospective observational study conducted over a three-year period and including all patients with cardiogenic shock...
December 26, 2017: Shock
https://www.readbyqxmd.com/read/29203173/evaluation-of-the-dynamic-predictors-of-fluid-responsiveness-in-dogs-receiving-goal-directed-fluid-therapy
#16
Maja J Drozdzynska, Yu-Mei Chang, Giacomo Stanzani, Ludovic Pelligand
OBJECTIVES: Goal-directed fluid therapy (GDFT) based on pulse pressure variation (PPV) was used in anaesthetized dogs undergoing abdominal surgeries. The aims were 1) to evaluate the success rate of the PPV ≥13% in detecting fluid responsiveness [delta stroke volume (ΔSV) ≥10%]; 2) to assess the correlation between PPV, systolic pressure variation (SPV), Plethysmograph Variability Index (PVI) and central venous pressure (CVP) and 3) to establish the threshold value for the PVI that would predict a PPV value of ≥13% and indirectly discriminate responders from nonresponders to fluid therapy...
January 2018: Veterinary Anaesthesia and Analgesia
https://www.readbyqxmd.com/read/29143247/using-circulating-tumor-cells-to-evaluate-the-efficacy-of-irreversible-electroporation-for-unresectasble-pancreatic-cancer
#17
Mao Lin, Mohammed Alnaggar, Shu-Zhen Liang, Jian Shi, Li-Zhi Niu, Ji-Bing Chen, Ke-Cheng Xu
We used circulating tumor cells (CTCs) as biomarkers to evaluate the efficacy of pre-irreversible electroporation (IRE) and post-IRE for unresectable pancreatic cancer (PC). Real-time qPCR was used to detect potential biomarker genes in CTCs, and magnetic-activated cell sorting (MACS) and fluorescence-activated cell sorting (FACS) were performed on 43 patients with PC who underwent IRE. Some patients experienced adverse reactions within 30 days of the operation, including arrhythmia (6.9%), intraoperative transient change of blood pressure (25...
November 15, 2017: Immunologic Research
https://www.readbyqxmd.com/read/29120588/association-between-serpinb2-gene-expression-by-real-time-pcr-in-respiratory-epithelial-cells-and-atopic-bronchial-asthma-severity
#18
Nissreen E ELBadawy, Randa S Abdel-Latif, Hoda A El-Hady
Atopic bronchial asthma is chronic respiratory diseases of high frequency and high morbidity and mortality especially in patients refractory to the ordinary medical management. This study aimed to investigate the association between Serpin family B Member 2 (SERPINB2) gene expression and bronchial asthma severity. A total of 127 adult patients with asthma were enrolled in this study. Allergic respiratory symptoms were assessed and patients were classified according to Global Initiative for Asthma (GINA) criteria...
January 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29119875/effects-of-positive-end-expiratory-pressure-on-intraoperative-core-temperature-in-patients-undergoing-posterior-spine-surgery-prospective-randomised-trial
#19
Hyungseok Seo, Je Do Son, Hyung-Chul Lee, Hyung-Min Oh, Chul-Woo Jung, Hee-Pyoung Park
Objective Positive end-expiratory pressure (PEEP) causes carotid baroreceptor unloading, which leads to thermoregulatory peripheral vasoconstriction. However, the effects of PEEP on intraoperative thermoregulation in the prone position remain unknown. Methods Thirty-seven patients undergoing spine surgery in the prone position were assigned at random to receive either 10 cmH2O PEEP (Group P) or no PEEP (Group Z). The primary endpoint was core temperature 180 minutes after intubation. Secondary endpoints were delta core temperature (difference in core temperature between 180 minutes and immediately after tracheal intubation), incidence of intraoperative hypothermia (core temperature of <36°C), and peripheral vasoconstriction-related data...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/29113517/shock-index-and-delta-shock-index-are-superior-to-existing-maternal-early-warning-criteria-to-identify-postpartum-hemorrhage-and-need-for-intervention
#20
Jaden R Kohn, Gary A Dildy, Catherine S Eppes
OBJECTIVE: To determine whether shock index (SI) is superior to traditional vital signs in predicting postpartum hemorrhage and need for intervention. METHODS: Retrospective case-control study in an academic tertiary-care county hospital. Forty-one consecutive postpartum hemorrhage (PPH) cases and 41 controls were frequency-matched by mode of delivery and maternal weight. We measured four criteria: heart rate, systolic blood pressure (SBP), SI (HR/SBP), and delta-SI (peak SI - baseline SI)...
February 4, 2018: Journal of Maternal-fetal & Neonatal Medicine
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