keyword
https://read.qxmd.com/read/37512518/rosacea-meibomian-gland-dysfunction-posterior-blepharitis-may-be-a-marker-for-earlier-associated-dyslipidaemia-and-inflammation-detection-and-treatment-with-statins
#21
JOURNAL ARTICLE
Kenneth G Ooi, Stephanie L Watson
Posterior blepharitis and dry eye are common disorders with meibomian gland dysfunction (MGD), a principal driver of their pathophysiology. Meibomian gland dysfunction is increasingly prevalent in older populations with contributory hormonal imbalances. The abnormal meibum in MGD has been documented to have an excess of cholesterol with a resultant disruption of the lipid layer of the tear film. This leads to tear film instability due to the inadequate trapping of the aqueous portion of the tear film with resultant evaporative dry eye...
June 30, 2023: Metabolites
https://read.qxmd.com/read/37506368/effects-on-the-human-tear-film-of-applying-skin-lipids-to-the-ocular-surface
#22
JOURNAL ARTICLE
Jim Kokkinakis, Burkhardt S Schuett, Thomas J Millar
PURPOSE: The effect of skin lipids on the formation and stability of the human tear film was investigated. METHODS: Skin swab substances (SSSs) were applied to the eyes of volunteers and studied using fluorescein or with TearView, which records infrared emissivity showing tear film integrity in real time. Results were compared with similar experiments using castor oil, freshly collected meibum, or acetic acid, which simulated the low pH of the skin. RESULTS: Fluorescein and TearView results were comparable...
July 27, 2023: Cornea
https://read.qxmd.com/read/37420126/application-of-topical-2-cyclosporine-a-in-inflammatory-ocular-surface-diseases
#23
JOURNAL ARTICLE
Leyla Asena, Dilek Dursun Altınörs
PURPOSE: To report our experience with the 2% cyclosporin A (CsA) in a series of challenging inflammatory ocular surface diseases due to different etiologies. METHODS: The records of patients who received topical 2% CsA for different indications were reviewed retrospectively. Demographic characteristics, indications for treatment, patient symptoms and clinical findings were recorded. RESULTS: Fifty-two eyes of 52 patients were included. Mean age was 43...
July 7, 2023: International Ophthalmology
https://read.qxmd.com/read/37363964/conjunctival-microbiota-and-blepharitis-symptom-scores-in-patients-with-ocular-rosacea
#24
JOURNAL ARTICLE
Burak Mergen, Irem Onal, Abdurrahman Gulmez, Ceyda Caytemel, Yusuf Yildirim
PURPOSE: Investigation of the relationship between blepharitis-related symptom scores, tear film functions, and conjunctival microbiota in patients with ocular rosacea (OR) compared with healthy controls was aimed. METHODS: Consecutive 33 eyes of 33 patients with OR who were admitted from the dermatology clinic and age-matched and gender-matched 30 healthy controls were included in the study. Tear breakup time (TBUT), Schirmer score, and blepharitis symptom score (BLISS) were recorded for each patient...
June 26, 2023: Eye & Contact Lens
https://read.qxmd.com/read/37336467/optical-coherence-tomography-angiography-aspects-of-the-retinal-and-optic-disc-microvascular-morphology-in-erythemato-telangectatic-rosacea
#25
JOURNAL ARTICLE
A Y İbrahim Ethem, Seçil Soylu, E R Aynur, İrem Nur Durusu, Mustafa Doğan, Hamidu Hamisi Gobeka
BACKGROUND: To investigate retinal and optic disc (OD) microvascular morphological changes in erythemato-telangiectatic rosacea (ETR) patients using optical coherence tomography angiography (OCTA), and compare the findings to age- and gender-matched healthy individuals METHODS: This study included newly diagnosed 31 ETR patients (31 right eyes, group 1) who were clinically diagnosed by two experienced dermatologists. A control group had 32 healthy individuals (32 right eyes, group 2)...
June 17, 2023: Photodiagnosis and Photodynamic Therapy
https://read.qxmd.com/read/37297954/increased-risk-of-glaucoma-in-patients-with-rosacea-a-nationwide-population-based-cohort-study
#26
JOURNAL ARTICLE
Kyunghee Chae, Suyeon Kim, Sukil Kim, Yu Ri Woo
Rosacea is a chronic inflammatory skin disorder associated with various ocular manifestations. However, little is known about the association between rosacea and glaucoma. This study aimed to determine the risk of glaucoma in patients with rosacea. This nationwide population-based retrospective cohort study enrolled 1056 individuals with rosacea and 10,440 age- and sex-matched controls without rosacea from the Korean National Health Insurance System (NHIS) database from 2002 to 2015. The incidence rate of glaucoma was 1215...
May 30, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/37276164/neurogenic-rosacea-treatment-a-literature-review
#27
REVIEW
Mirjana G Ivanic, Aislyn Oulee, Alexandra Norden, Sogol S Javadi, Michael H Gold, Jashin J Wu
Rosacea is a chronic skin disorder involving central facial erythema secondary to vascular instability and cutaneous inflammation. Rosacea is divided into different subtypes based on the morphology of the rash — erythematotelangiectatic, papulopustular, phymatous, and ocular rosacea. A less-known subtype called neurogenic rosacea has been proposed to categorize patients suffering from rosacea with erythematous flushing and burning sensation that is refractory to traditional treatment. There is minimal data on this subgroup of rosacea patients and its potential treatment options...
June 1, 2023: Journal of Drugs in Dermatology: JDD
https://read.qxmd.com/read/37252167/peripheral-ulcerative-keratitis-in-a-patient-with-granulomatous-rosacea
#28
Fang-Chi Hsiao, Yaa-Jyuhn James Meir, Ching-Hsi Hsiao, Kuan-Jen Chen, David Hui-Kang Ma, Wei-Chi Wu, Hung-Chi Chen
A 24-year-old woman visited our emergency department due to intermittent dull pain in the right eye, blurred vision, foreign body sensation for 3 weeks, and progressive facial rash with pustules for 3 months. She had a history of recurring skin rash on her face and extremities since early adolescence. Peripheral ulcerative keratitis (PUK) was diagnosed based on slit-lamp examination and corneal topography and then granulomatous rosacea (GR) based on clinical manifestations and skin pathology. Topical prednisolone, artificial tears, oral doxycycline, oral prednisolone, and topical clindamycin were administered...
2023: Taiwan Journal of Ophthalmology
https://read.qxmd.com/read/37153945/ocular-rosacea-an-under-recognized-entity
#29
JOURNAL ARTICLE
Madeleine Andreas, Anna Fabczak-Kubicka, Robert A Schwartz
While rosacea is a common dermatologic condition, ocular rosacea is sometimes evident either with cutaneous rosacea or occasionally by itself. Manifesting with such varied symptoms as dry eye, Meibomian gland dysfunction, and corneal erosion, ocular rosacea can be confused with a multitude of other diseases. While ocular rosacea is commonly mild and rarely severe, physicians should still expand their examination to include ocular manifestations of rosacea. In addition, we propose diagnostic criteria for ocular rosacea, stressing the importance of early recognition and treatment...
April 2023: Italian journal of dermatology and venereology
https://read.qxmd.com/read/37106092/-differential-diagnoses-of-ocular-mucous-membrane-pemphigoid
#30
REVIEW
Philipp Steven
Overall, conjunctival scarring is rare and often overlooked during routine examination. However, the differential diagnostic distinction of cicatricial mucous membrane pemphigoid from other causes is crucial for further treatment planning. Other entities that lead to conjunctival scarring, are ocular rosacea, ocular graft-versus-host disease, atopic keratoconjunctivitis, infections, trauma and further sometimes very rare diseases. Most of these differential diagnoses have in common that conjunctival scarring does not progress indefinitely if untreated, in contrast to mucous membrane pemphigoid...
April 27, 2023: Ophthalmologie
https://read.qxmd.com/read/37088101/clinical-features-and-management-of-keratoconjunctivitis-associated-with-inadequate-tear-drainage
#31
JOURNAL ARTICLE
Larissa Gouvea, Michael Mimouni, Sara Alshaker, Nizar Din, Dan D Deangelis, Nancy Tucker, Harmeet Gill, Allan R Slomovic, Clara C Chan
OBJECTIVE: To describe clinical features and management of toxic keratoconjunctivitis associated with punctal and (or) canaliculus stenosis (toxic soup syndrome). DESIGN: Retrospective observational case series. METHODS: Electronic medical record database search for the keywords "toxic soup syndrome" and retrospective chart review were performed. Thirty-five eyes of 25 patients were seen at a tertiary cornea clinic between January 2017 and December 2021...
April 20, 2023: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://read.qxmd.com/read/37032590/risk-factors-for-chalazion-diagnosis-and-subsequent-surgical-excision
#32
JOURNAL ARTICLE
Diana H Kim, César A Briceño, Brendan McGeehan, Brian L VanderBeek
PURPOSE: To identify factors associated with chalazion diagnosis and surgical excision. METHODS: Patients with an incident chalazion diagnosis from 2002 to 2019 were compared 1:5 with matched controls. Multivariable logistic regression was performed to identify variables associated with diagnosis and surgical excision. RESULTS: Chalazion patients ( n  = 134,959) and controls (678,160) were analyzed. Risk factors for diagnosis included female sex, non-white race, northeast location, conditions affecting periocular skin and tear film (blepharitis, meibomian gland dysfunction, rosacea, pterygium), non-ocular inflammatory conditions (gastritis, inflammatory bowel disease, sarcoidosis, seborrheic dermatitis, Graves' disease), and smoking ( p  < ...
April 9, 2023: Ophthalmic Epidemiology
https://read.qxmd.com/read/37026270/preferred-practice-patterns-and-review-on-rosacea
#33
JOURNAL ARTICLE
Nikunj V Patel, Nidhi Gupta, Rohit Shetty
Rosacea is a chronic, inflammatory facial dermatosis commonly found in fair skin tone population. Recent studies have shown the increasing prevalence in the dark skin tone population as well. Ocular involvement is very common and can occur without cutaneous features. Common ocular features are chronic blepharoconjunctivitis with eyelid margin inflammation and meibomian gland dysfunction. Corneal complications include corneal vascularization, ulceration, scarring, and rarely, perforation. Diagnosis is largely based on clinical signs, although it is often delayed in the absence of cutaneous changes, particularly in children...
April 2023: Indian Journal of Ophthalmology
https://read.qxmd.com/read/36927050/a-review-of-applications-and-intracellular-mechanisms-of-intense-pulsed-light-in-eyelid-inflammatory-diseases
#34
REVIEW
Hongya Zeng, Lan Gong
Objective: To evaluate relevant clinical outcomes and conclude possible mechanisms of intense pulsed light (IPL) in eyelid inflammation. Background: IPL devices were primarily applied in cutaneous vascular malformations and have been used in ocular diseases for about 20 years, mostly including meibomian gland dysfunction (MGD), blepharitis, and ocular rosacea. Recent findings: Seventy-two original clinical researches were included, 57 for MGD, 4 for blepharitis or blepharitis-related keratoconjunctivitis, and 11 for rosacea...
March 2023: Photobiomodulation, photomedicine, and laser surgery
https://read.qxmd.com/read/36836184/demodicosis-in-different-age-groups-and-alternative-treatment-options-a-review
#35
REVIEW
Izabela Chudzicka-Strugała, Iwona Gołębiewska, Grzegorz Brudecki, Wael Elamin, Barbara Zwoździak
Infestation with Demodex mites is a common occurrence, especially in adults and the elderly. More recent attention has been paid to the presence of Demodex spp. mites in children, even ones without comorbidities. It causes both dermatological and ophthalmological problems. The presence of Demodex spp. is often asymptomatic, thus it is suggested to include parasitological investigation tests in dermatological diagnostics, in addition to bacteriological analysis. Literature reports show that Demodex spp. are related to the pathogenesis of numerous dermatoses, including rosacea or demodicosis gravis, and common eye pathologies reported by patients such as dry eye syndrome or ocular surface inflammatory conditions, such as blepharitis, chalazia, Meibomian gland dysfunction, and keratitis...
February 19, 2023: Journal of Clinical Medicine
https://read.qxmd.com/read/36751313/sh2-domain-containing-protein-tyrosine-phosphatase-2-is%C3%A2-enriched-in-eyelid-specimens-of-rosacea
#36
JOURNAL ARTICLE
Apoorv Chebolu, Ramon Bossardi Ramos, Thilaka Arunachalam, Alejandro Pablo Adam, Edward J Wladis
BACKGROUND: Rosacea is a cutaneous disease that may secondarily affect the ocular surface. Due to the vision threatening, cosmetic, psychological, and work productivity impact, the identification of cellular targets that govern rosacea would enhance our understanding of the biology of the disease and delineate targets for therapeutic manipulation. OBJECTIVE: To characterize the involvement of SH2 domain-containing protein tyrosine phosphatase-2 (SHP2) in the pathogenesis of rosacea...
February 2023: Skin Health Dis
https://read.qxmd.com/read/36539810/ocular-rosacea-microbiome-study-orbs-sub-microbial-versus-antibiotic-dosing-of-doxycycline-versus-placebo-in-treatment-of-symptomatic-ocular-rosacea-study-protocol-for-a-parallel-arm-randomized-clinical-trial
#37
JOURNAL ARTICLE
Hamidah Mahmud, Jeremy D Keenan, John Gonzales, Julie Schallhorn, Matilda Chan, Benjamin Arnold, Victoria Cavallino, Thomas M Lietman, Thuy Doan, Gerami D Seitzman
BACKGROUND: Ocular rosacea is common and is often managed with long-term antibiotic treatment. Doxycycline is the most commonly selected antibiotic for the treatment of rosacea. As there is no established standard of care treatment dose for rosacea, prescribed doses of doxycycline vary widely. The FDA classifies 40 mg daily dose of doxycycline for ocular rosacea as sub-microbial in comparison to an antibiotic dose of 200 mg daily. However, this "sub-microbial" dose has never been evaluated in patients with ocular rosacea, and even the sub-microbial dose has potential to alter systemic mucosa flora...
December 20, 2022: Trials
https://read.qxmd.com/read/36417674/diabetic-patients-with-rosacea-increase-the-risks-of-diabetic-macular-edema-dry-eye-disease-glaucoma-and-cataract
#38
JOURNAL ARTICLE
Fang-Ying Wang, Eugene Yu-Chuan Kang, Chun-Hao Liu, Chau Yee Ng, Shih-Chieh Shao, Edward Chia-Cheng Lai, Wei-Chi Wu, Yi-You Huang, Kuan-Jen Chen, Chi-Chun Lai, Yih-Shiou Hwang
PURPOSE: Inflammation plays a role in diabetic eye diseases, but the association between rosacea and eye diseases in patients with diabetes remains unknown. DESIGN: This retrospective cohort study used claims data from the National Health Insurance Research Database in Taiwan to investigate the association between rosacea and eye diseases in patients with diabetes. MATERIALS AND METHODS: Taiwanese patients diagnosed as having diabetes mellitus between January 1, 1997, and December 31, 2013, and using any hypoglycemic agents were included and divided into rosacea and nonrosacea groups...
November 1, 2022: Asia-Pacific Journal of Ophthalmology
https://read.qxmd.com/read/36383391/dry-eye-subtypes-in-the-dry-eye-assessment-and-management-dream-study-a-latent-profile-analysis
#39
RANDOMIZED CONTROLLED TRIAL
Kimberley Yu, Penny A Asbell, Roni M Shtein, Gui-Shuang Ying
Purpose: Dry eye disease (DED) is a heterogeneous condition with poorly characterized subtypes. The DREAM study was a large multicenter randomized clinical trial that did not find omega-3 to be more effective than placebo in treating symptomatic DED. We performed secondary analysis of DREAM data to characterize DED subtypes and their omega-3 response. Methods: A total of 535 patients with moderate-to-severe DED were randomized to omega-3 or placebo treatment for one year...
November 1, 2022: Translational Vision Science & Technology
https://read.qxmd.com/read/36341245/clinical-characteristics-of-combined-rosacea-and-migraine
#40
JOURNAL ARTICLE
Nita K F Wienholtz, Casper E Christensen, Ditte G Zhang, Anne-Sofie A Rechnagel, Helene V S Byrnel, Jeanette H Haugaard, Messoud Ashina, Jacob P Thyssen, Alexander Egeberg
Background: An overlap between the skin disease rosacea and the headache disease migraine has been established; however, the magnitude of this overlap and the distribution between subtypes/phenotypes remains unclear. Objective: The aim was to determine the magnitude of the overlap between rosacea and migraine, and to determine which subtypes/phenotypes were present in patients with concomitant rosacea and migraine. Methods: In this cross-sectional study, 604 patients with a diagnosis of either rosacea or migraine were phenotyped through a face-to-face interview with clinical examination, to determine prevalence and phenotype of rosacea, and prevalence and subtype of migraine...
2022: Frontiers in Medicine
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