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Ocular rosacea

M Schaller, L Almeida, A Bewley, B Cribier, N Dlova, G Kautz, M Mannis, H Oon, M Rajagopalan, M Steinhoff, D Thiboutot, P Troielli, G Webster, Y Wu, E van Zuuren, J Tan
BACKGROUND: Rosacea is currently treated according to subtypes. As this does not adequately address the patient spectrum of clinical presentation (phenotypes), it has implications for patient management. The ROSacea COnsensus (ROSCO) panel was established to address this issue. OBJECTIVES: To incorporate current best treatment evidence with clinical experience from an international expert panel and establish consensus to improve outcomes for patients with rosacea...
November 12, 2016: British Journal of Dermatology
Manal Abokwidir, Steven R Feldman
BACKGROUND: Rosacea is a chronic inflammatory skin condition associated with four distinct subtypes: erythematotelangiectatic, papulopustular, phymatous, and ocular. PURPOSE: To review the different kinds of management for all subtypes. METHODS: We divided rosacea management into three main categories: patient education, skin care, and pharmacological/procedural interventions. RESULTS: Flushing is better prevented rather than treated, by avoiding specific triggers, decreasing transepidermal water loss by moisturizers, and blocking ultraviolet light...
September 2016: Skin Appendage Disorders
Alexander Egeberg, Messoud Ashina, David Gaist, Gunnar H Gislason, Jacob P Thyssen
BACKGROUND: Rosacea features increased neurovascular reactivity; migraine is a complex neurologic disorder characterized by recurrent episodes of headache associated with nausea and increased sensitivity to light and sound. OBJECTIVE: We evaluated the prevalence and risk of new-onset migraine in patients with rosacea. METHODS: All Danish individuals 18 years of age or older were linked in nationwide registers. Adjusted hazard ratios (HRs) were estimated by Cox regression...
November 3, 2016: Journal of the American Academy of Dermatology
İlkay Kılıç Müftüoğlu, Yonca Aydın Akova
OBJECTIVES: To report the clinical features, treatment options and complications in patients with ocular rosacea. MATERIALS AND METHODS: The records of 48 eyes of 24 patients with ocular rosacea were retrospectively reviewed. Patients' ocular signs and symptoms were scored between 1 and 4 points according to disease severity; tear film break-up time (BUT) and Schirmer's test results were recorded before and after the treatment. Preservative-free artificial tears, topical antibiotic eye drops/ointments, short-term topical corticosteroids, topical 0...
January 2016: Turkish Journal of Ophthalmology
Sevil Karaman Erdur
No abstract text is available yet for this article.
November 2016: Eye & Contact Lens
Melis Palamar, Cumali Degirmenci, Ilgen Ertam, Ayse Yagci
No abstract text is available yet for this article.
November 2016: Eye & Contact Lens
J Tan, L Almeida, A Bewley, B Cribier, N Dlova, R Gallo, G Kautz, M Mannis, H Oon, M Rajagopalan, M Steinhoff, D Thiboutot, P Troielli, G Webster, Y Wu, E van Zuuren, M Schaller
BACKGROUND: Rosacea is currently diagnosed by consensus-defined primary and secondary features and managed by subtype. However, individual features (phenotypes) can span multiple subtypes, which has implications for clinical practice and research. Adopting a phenotype-led approach may facilitate patient-centred management. OBJECTIVES: To advance clinical practice by obtaining international consensus to establish a phenotype-led rosacea diagnosis and classification scheme with global representation...
October 8, 2016: British Journal of Dermatology
Yu Ri Woo, Ji Hong Lim, Dae Ho Cho, Hyun Jeong Park
Rosacea is a chronic cutaneous inflammatory disease that affects the facial skin. Clinically, rosacea can be categorized into papulopustular, erythematotelangiectatic, ocular, and phymatous rosacea. However, the phenotypic presentations of rosacea are more heterogeneous. Although the pathophysiology of rosacea remains to be elucidated, immunologic alterations and neurovascular dysregulation are thought to have important roles in initiating and strengthening the clinical manifestations of rosacea. In this article, we present the possible molecular mechanisms of rosacea based on recent laboratory and clinical studies...
September 15, 2016: International Journal of Molecular Sciences
Roselyn Kellen, Nanette B Silverberg
Because rosacea is uncommon in the pediatric population, care must be taken to exclude other papulopustular disorders. Children can present with vascular, papulopustular, and/or ocular findings. Importantly, ocular symptoms can appear before the cutaneous symptoms of rosacea, leading to misdiagnosis. Rosacea is a clinical diagnosis, but histopathologic examination typically reveals dilated vessels, perivascular lymphohistiocytic infiltrates in the upper dermis, elastosis, and disorganization of the upper dermal connective tissue...
July 2016: Cutis; Cutaneous Medicine for the Practitioner
Gloria López-Valverde, Elena Garcia-Martin, José Manuel Larrosa-Povés, Vicente Polo-Llorens, Luis E Pablo-Júlvez
PURPOSE: The purpose of this study is to describe a case of ocular rosacea with a very complex evolution. Rosacea is a chronic dermatological disease that may affect the ocular structures up to 6-72% of all cases. This form is often misdiagnosed, which may lead to long inflammatory processes with important visual consequences for affected patients. Therefore, an early diagnosis and an adequate treatment are important. METHODS: We report the case of a 43-year-old patient who had several relapses of what seemed an episode of acute bacterial conjunctivitis...
January 2016: Case Reports in Ophthalmology
Yolanda R Helfrich, Lisa M Maier
Rosacea is an inflammatory condition of the skin, primarily affecting the central convexities of the face. Various topical and oral therapeutic approaches exist. Most have been developed to treat the papulopustular subtype of rosacea; however, other approaches can be used to treat the erythematotelangiectatic, ocular, and phymatous subtypes. This review provides a summary of available topical and oral approaches for the treatment of rosacea.
June 2016: Seminars in Cutaneous Medicine and Surgery
Hong Liang, Matthieu Randon, Sylvain Michee, Rachid Tahiri, Antoine Labbe, Christophe Baudouin
AIMS: The physiopathology of rosacea and the correlation between ocular and cutaneous rosacea remains unclear. This study analysed ocular and cutaneous rosacea with in vivo confocal microscopy (IVCM). METHODS: Thirty-four eyes of 34 patients with confirmed rosacea-associated meibomian gland dysfunction-related evaporative dry eye were enrolled in the study. The ophthalmological investigations included dry eye ocular surface disease index (OSDI), the Schirmer test, tear osmolarity, tear break up time, the Oxford score, infrared meibography for meibomian gland (MG) analysis and IVCM investigation for cornea, MG and skin analysis (cheek, hand)...
May 24, 2016: British Journal of Ophthalmology
Yuka Asai, Jerry Tan, Akerke Baibergenova, Benjamin Barankin, Chris L Cochrane, Shannon Humphrey, Charles W Lynde, Danielle Marcoux, Yves Poulin, Jason K Rivers, Mariusz Sapijaszko, R Gary Sibbald, John Toole, Marcie Ulmer, Catherine Zip
Rosacea is a chronic facial inflammatory dermatosis characterized by background facial erythema and flushing and may be accompanied by inflammatory papules and pustules, cutaneous fibrosis and hyperplasia known as phyma, and ocular involvement. These features can have adverse impact on quality of life, and ocular involvement can lead to visual dysfunction. The past decade has witnessed increased research into pathogenic pathways involved in rosacea and the introduction of novel treatment innovations. The objective of these guidelines is to offer evidence-based recommendations to assist Canadian health care providers in the diagnosis and management of rosacea...
September 2016: Journal of Cutaneous Medicine and Surgery
Justine Czernielewski, Curdin Conrad
Rosacea is a common chronic inflammatory skin disease with a variety of clinical manifestations such as centro-facial erythema, papules and pustules, as well as ocular involvement. Based on these manifestations, rosacea is clinically divided into four subtypes necessitating distinct therapies. Despite recent scientific advances, the pathomechanisms underlying rosacea in general and the different subtypes in particular are still elusive. Accordingly, current treatment options remain mostly broad and symptomatic...
March 30, 2016: Revue Médicale Suisse
Bianka Sobolewska, Eva Angermair, Christoph Deuter, Deshka Doycheva, Jasmin Kuemmerle-Deschner, Manfred Zierhut
OBJECTIVE: Cryopyrin-associated periodic syndrome (CAPS) is a group of inherited autoinflammatory disorders caused by mutations in the NLRP3 gene resulting in the overproduction of interleukin 1β. NLRP3 mutations cause a broad clinical phenotype of CAPS. The aims of the study were to evaluate clinical, laboratory, and genetic features of a 5-generation family with CAPS focusing in detail on ocular symptoms. METHODS: In a retrospective observational cohort study, consecutive family members were screened for the presence of the NLRP3 mutation...
June 2016: Journal of Rheumatology
Rahul Bhargava, Mini Chandra, Utsav Bansal, Divya Singh, Somesh Ranjan, Shalini Sharma
: Objective or purpose: To evaluate the efficacy of dietary omega-3 fatty acids (O3FAs) in rosacea patients having dry eye symptoms. METHODS: A prospective, interventional, randomized, double-masked, placebo-controlled, multi-centric study was done. Symptomatic patients with rosacea were recruited based on their response to (Dry Eye Scoring System, DESS©); a score of 0-3 was assigned to dry eye-related symptoms like ocular fatigue, blurring of vision, itching or burning, sandy or gritty sensation, and redness, respectively (DESS©)...
April 6, 2016: Current Eye Research
Alexander Egeberg, Peter Riis Hansen, Gunnar H Gislason, Jacob P Thyssen
IMPORTANCE: The pathogenesis of rosacea is unclear, but increased matrix metalloproteinase target tissue activity appears to play an important role. Parkinson disease and other neurodegenerative disorders also display increased matrix metalloproteinase activity that contribute to neuronal loss. OBJECTIVE: To investigate the risk of incident (new-onset) Parkinson disease in patients with rosacea. DESIGN, SETTING, AND PARTICIPANTS: A nationwide cohort study of the Danish population was conducted using individual-level linkage of administrative registers...
May 1, 2016: JAMA Neurology
Melis Palamar, Cumali Degirmenci, Ilgen Ertam, Ayse Yagci
Rosacea is a chronic cutaneous disorder which is known to cause inflammation and increased proteolytic activity on the ocular surface that might lead to corneal biomechanical alterations. The aim of this study is to evaluate the corneal biomechanical properties of ocular rosacea patients and compare the measurements with healthy individuals as measured with Reichert ocular response analyser (ORA). Besides full eye examination [best corrected visual acuity (BCVA), intraocular pressure (IOP) measured with Goldmann applanation tonometry (IOP-G)], central corneal thickness (CCT), and ORA [corneal hysteresis (CH), corneal resistance factor (CRF), corneal compensated IOP (IOPcc), Goldmann correlated IOP (IOPg)] measurements of 30 eyes of 15 ocular rosacea patients (study group) and 30 eyes of 15 healthy individuals (control group) were performed...
March 12, 2016: International Ophthalmology
Nurgül Örnek, Ayşe Anıl Karabulut, Kemal Örnek, Zafer Onaran, Gülşah Usta
PURPOSE: To assess corneal and conjunctival sensitivity in rosacea patients. METHODS: A total of 55 patients with rosacea and 37 control subjects participated in the study. Corneal and conjunctival sensitivity was determined by Cochet-Bonnet esthesiometer. Subjective symptoms of ocular dryness were evaluated using Ocular Surface Disease Index (OSDI). Schirmer's I test (ST), tear breakup time (tBUT) and ocular surface staining with fluorescein were carried out to measure objective signs...
January 2016: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
Rimvydas Asoklis, Kristina Malysko
A 58-year-old man presented with recurrent flushing of the face and redness, foreign-body sensation, and blurred vision in both eyes. These symptoms had persisted for 6 years, with intermittent remissions lasting up to 12 weeks. The best corrected visual acuity was 20/20 in the right eye and 20/25..
February 25, 2016: New England Journal of Medicine
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