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Scedosporium apiospermum

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https://www.readbyqxmd.com/read/28504471/scedosporium-apiospermum-complex-in-cystic-fibrosis-should-we-treat
#1
Maria Noni, Anna Katelari, Aikaterini Kapi, Angeliki Stathi, George Dimopoulos, Stavros-Eleftherios Doudounakis
Species of the Scedosporium apiospermum complex are the second most frequent filamentous fungi after Aspergillus fumigatus that can be found in cystic fibrosis (CF). Mixed colonisation by S. apiospermum complex and A. fumigatus is also quite common. In this study we summarise all CF patients who were colonised by S. apiospermum complex during their childhood and we present two CF patients who were treated as fungal bronchitis due to S. apiospermum complex. The medical records of 400 CF patients were reviewed in order to identify those with positive respiratory cultures for S...
May 15, 2017: Mycoses
https://www.readbyqxmd.com/read/28410611/recurrent-scedosporium-apiospermum-mycetoma-successfully-treated-by-surgical-excision-and-terbinafine-treatment-a-case-report-and-review-of-the-literature
#2
Eszter J Tóth, Géza R Nagy, Mónika Homa, Marianna Ábrók, Ildikó É Kiss, Gábor Nagy, Zsuzsanna Bata-Csörgő, Lajos Kemény, Edit Urbán, Csaba Vágvölgyi, Tamás Papp
BACKGROUND: Scedosporium apiospermum is an emerging opportunistic filamentous fungus, which is notorious for its high levels of antifungal-resistance. It is able to cause localized cutaneous or subcutaneous infections in both immunocompromised and immunocompetent persons, pulmonary infections in patients with predisposing pulmonary diseases and invasive mycoses in immunocompromised patients. Subcutaneous infections caused by this fungus frequently show chronic mycetomatous manifestation...
April 14, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28333310/dihydroorotate-dehydrogenase-inhibitor-f901318-has-potent-in-vitro-activity-against-scedosporium-species-and-lomentospora-prolificans
#3
Nathan P Wiederhold, Derek Law, Michael Birch
Background: Scedosporium species and Lomentospora prolificans are increasing causes of invasive infections in immunocompromised hosts and many isolates are resistant to available antifungals. Our objective was to assess the in vitro potency of F901318, a member of the orotomide class of antifungals, against Scedosporium species and L. prolificans . Methods: The in vitro potency of F901318 was evaluated against 66 Scedosporium and 7 L. prolificans clinical isolates using the CLSI M38-A2 reference standard...
March 15, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28329186/fatal-bilateral-haemopneumothoraces-following-double-lung-transplantation-caused-by-pretransplant-colonization-by-scedosporium-apiospermum
#4
Francisco Javier Gonzalez-Garcia, Julia Guzman-Puche, Javier Redel-Montero, Paula Moreno
No abstract text is available yet for this article.
June 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28276198/anthropogenic-impact-on-environmental-filamentous-fungi-communities-along-the-mediterranean-littoral
#5
Mohammed Hashim Al-Yasiri, Anne-Cécile Normand, Jean-François Mauffrey, Stéphane Ranque
We hypothesised that anthropogenic influences impact the filamentous fungi community structure and that particular species or species patterns might serve as markers to characterise ecosystems. This study aimed to describe the filamentous fungi community structure in various biotopes along the Mediterranean shore that were exposed to various levels of anthropogenic influence. We sampled filamentous fungi from yellow-legged gull faecal samples at five study sites along the Mediterranean littoral in southern France...
March 9, 2017: Mycoses
https://www.readbyqxmd.com/read/28272067/prompt-diagnosis-of-scedosporium-apiospermum-soft-tissue-infection-life-saving-in-a-renal-transplant-recipient
#6
R Ghosh, P Mishra, P K Maiti, A Debnandi
Scedosporium apiospermum, an ubiquitous filamentous fungus, a known cause of mycetoma, is emerging as an opportunistic pathogen in immunocompromised individuals. We report a case of painful foot abscess in a renal allograft recipient on immunosuppressive therapy, which was clinically diagnosed as a suppurative bacterial abscess. Pus was aspirated, which showed septate, branching hyphal elements and culture on Sabouraud's dextrose agar yielded S. apiospermum, which was identified based on its macroscopic and microscopic features...
March 3, 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/28223376/bactericidal-and-fungicidal-activity-of-n-chlorotaurine-is-enhanced-in-cystic-fibrosis-sputum-medium
#7
Martina Gruber, Ivan Moser, Markus Nagl, Michaela Lackner
Lung infections with multiresistant pathogens are a major problem among patients suffering from cystic fibrosis (CF). N-Chlorotaurine (NCT), a microbicidal active chlorine compound with no development of resistance, is well tolerated upon inhalation. The aim of this study was to investigate the in vitro bactericidal and fungicidal activity of NCT in artificial sputum medium (ASM), which mimics the composition of CF mucus. The medium was inoculated with bacteria (Staphylococcus aureus, including some methicillin-resistant S...
May 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28192433/review-of-21-cases-of-mycetoma-from-1991-to-2014-in-rio-de-janeiro-brazil
#8
Felipe Maurício Soeiro Sampaio, Bodo Wanke, Dayvison Francis Saraiva Freitas, Janice Mery Chicarino de Oliveira Coelho, Maria Clara Gutierrez Galhardo, Marcelo Rosandiski Lyra, Maria Cristina da Silva Lourenço, Rodrigo de Almeida Paes, Antonio Carlos Francesconi do Valle
Mycetoma is caused by the subcutaneous inoculation of filamentous fungi or aerobic filamentous bacteria that form grains in the tissue. The purpose of this study is to describe the epidemiologic, clinic, laboratory, and therapeutic characteristics of patients with mycetoma at the Oswaldo Cruz Foundation in Rio de Janeiro, Brazil, between 1991 and 2014. Twenty-one cases of mycetoma were included in the study. There was a predominance of male patients (1.3:1) and the average patient age was 46 years. The majority of the cases were from the Southeast region of Brazil and the feet were the most affected anatomical region (80...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28178337/prospective-multicenter-german-study-on-pulmonary-colonization-with-scedosporium-lomentospora-species-in-cystic-fibrosis-epidemiology-and-new-association-factors
#9
Carsten Schwarz, Claudia Brandt, Elisabeth Antweiler, Alexander Krannich, Doris Staab, Sabina Schmitt-Grohé, Rainald Fischer, Dominik Hartl, Anja Thronicke, Kathrin Tintelnot
BACKGROUND: An increasing rate of respiratory colonization and infection in cystic fibrosis (CF) is caused by fungi of the Scedosporium apiospermum species complex or Lomentospora prolificans (Sac-Lp). These fungi rank second among the filamentous fungi colonizing the CF airways, after Aspergillus fumigatus. However, the epidemiology, clinical relevance and risk of pulmonary colonization with Sac-Lp are rarely understood in CF. The objective of the present prospective multicenter study was to study pathogen distribution and determine association factors of pulmonary Sac-Lp colonization in patients with CF...
2017: PloS One
https://www.readbyqxmd.com/read/28115402/surgical-resection-of-a-rare-cutaneous-manifestation-of-scedosporium-apiospermum-in-a-patient-who-underwent-renal-transplant
#10
A C S Stoneham, S E Stoneham, S A Wyllie, A N Pandya
A man aged 47 years who was immunosuppressed following renal transplantation for focal segmental glomerulosclerosis was referred to the Plastic Surgery team for management of a painful, chronic, granulomatous lesion of the right forearm. Serial ultrasound scans and MRI scans were not diagnostic, but microbiological specimens tested positive for the fungus Scedosporium apiospermum The renal transplant graft-which was failing-was removed, allowing him to cease immunosuppression. He then underwent a resection of the lesion and reconstruction with a split thickness skin graft...
January 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28088169/tenosynovitis-caused-by-scedosporium-apiospermum-infection-misdiagnosed-as-an-alternaria-species-a-case-report
#11
Choon-Mee Kim, Sung-Chul Lim, Joa Kim, Hoe-Soo Jang, Jong-Hun Chung, Na-Ra Yun, Dong-Min Kim, Piyush Jha, Babita Jha, Seok Won Kim, Sook Jin Jang, Jong Hee Shin
BACKGROUND: Scedosporium apiospermum, which can usually be isolated from soil, polluted stream water and decaying vegetation, is increasingly recognized as an opportunistic dematiaceous fungus. The mortality rate of infection in immunocompromised hosts is over 50%. S. apiospermum is commonly responsible for dermal and epidermal infections (i.e., mycetoma) after traumatic penetration. CASE PRESENTATION: A 73-year-old woman was admitted to our hospital complaining of painful swelling and tenderness on the dorsum of the proximal left wrist and hand...
January 14, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28053848/rapid-development-of-a-mycotic-aneurysm-of-the-intracranial-artery-secondary-to-scedosporium-apiospermum-sinusitis
#12
Yoshihiko Ogawa, Masatoshi Sato, Masato Tashiro, Masayuki Miyazaki, Kiyoshi Nagata, Nobuyuki Takahashi, Kei Kasahara, Koichi Izumikawa, Hisakazu Yano, Keiichi Mikasa
An 85-year-old man complained of a 2-month history of pain on the left side of his face. Brain computed tomography (CT) and magnetic resonance imaging/magnetic resonance angiography did not clearly show any intracranial abnormality and only showed fluid effusion in his left sphenoid sinus. Filamentous fungi were detected from the left sphenoid sinus specimen. The isolate was Scedosporium apiospermum. He was empirically treated with voriconazole, to which the isolate was susceptible. His consciousness decreased rapidly...
December 2016: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28035880/scedosporium-apiospermum-mycetoma-in-an-immunocompetent-patient-without-prior-lung-disease
#13
Kevin C Ma, Alejandro Pino, Navneet Narula, Meredith L Turetz
No abstract text is available yet for this article.
January 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28031271/voriconazole-mics-are-predictive-for-the-outcome-of-experimental-disseminated-scedosporiosis
#14
Adela Martin-Vicente, Josep Guarro, Gloria M González, Cornelia Lass-Flörl, Michaela Lackner, Javier Capilla
Background: Scedosporiosis is associated with a mortality rate of up to 90% in patients suffering from disseminated infections. Recommended first-line treatment is voriconazole, but epidemiological cut-off values and clinical breakpoints have not been determined. Objectives: To correlate voriconazole treatment response in mice suffering from disseminated scedosporiosis with MIC values determined using CLSI broth microdilution, Etest (bioMérieux) and disc diffusion...
April 1, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28018093/clinico-radiological-improvement-in-an-immunocompetent-patient-presented-with-scedosporium-apiospermum-osteomyelitis
#15
Rahul Mohan, T S Gopakumar
Scedosporium apiospermum is frequently found as a saprophyte in soil, sewage and contaminated water. Its manifestations in immunocompetent patients are usually localised and in immunodeficient patients, it causes invasive systemic diseases. We are reporting the case of a 40-year-old male, who presented with pain, oedema and multiple discharging sinuses over the lateral aspect of the left foot with history of thorn prick. On examination, there were multiple active sinuses with tenderness and local rise in temperature...
October 2016: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/27702795/prevention-of-polymicrobial-biofilms-composed-of-pseudomonas-aeruginosa-and-pathogenic-fungi-by-essential-oils-from-selected-citrus-species
#16
Marina Pekmezovic, Ivana Aleksic, Aleksandra Barac, Valentina Arsic-Arsenijevic, Branka Vasiljevic, Jasmina Nikodinovic-Runic, Lidija Senerovic
Mixed microbial infections caused by Pseudomonas aeruginosa and pathogenic fungi are commonly found in patients with chronic infections and constitute a significant health care burden. The aim of this study was to address the potential polymicrobial antibiofilm activity of pompia and grapefruit essential oils (EOs). The mechanism of antimicrobial activity of EOs was analysed. EOs of pompia and grapefruit inhibited fungal growth with MIC concentrations between 50 and 250 mg L(-1), whereas no effect on P. aeruginosa growth was observed...
November 2016: Pathogens and Disease
https://www.readbyqxmd.com/read/27613266/scedosporium-apiospermum-a-rare-cause-of-malignant-otitis-externa
#17
Oliver McLaren, Christian Potter
A 79-year-old man, with a history of well-controlled diabetes mellitus, presented with left-sided otalgia. With an initial diagnosis of simple otitis externa, he was discharged on topical drops. He represented 2 months later with worsening otalgia and discharge. A diagnosis of malignant otitis externa was made based on clinical and radiological findings. Intravenous Tazocin and Gentamicin were given based on previous bacterial culture from ear swabs. The patient failed to improve and developed left-sided facial nerve palsy...
September 9, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27605714/discrimination-of-aspergillosis-mucormycosis-fusariosis-and-scedosporiosis-in-formalin-fixed-paraffin-embedded-tissue-specimens-by-use-of-multiple-real-time-quantitative-pcr-assays
#18
Elham Salehi, Mohammad T Hedayati, Jan Zoll, Haleh Rafati, Maryam Ghasemi, Atosa Doroudinia, Mahdi Abastabar, Ali Tolooe, Eveline Snelders, Henrich A van der Lee, Antonius J M M Rijs, Paul E Verweij, Seyedmojtaba Seyedmousavi, Willem J G Melchers
In a retrospective multicenter study, 102 formalin-fixed paraffin-embedded (FFPE) tissue specimens with histopathology results were tested. Two 4- to 5-μm FFPE tissue sections from each specimen were digested with proteinase K, followed by automated nucleic acid extraction. Multiple real-time quantitative PCR (qPCR) assays targeting the internal transcribed spacer 2 (ITS2) region of ribosomal DNA, using fluorescently labeled primers, was performed to identify clinically important genera and species of Aspergillus, Fusarium, Scedosporium, and the Mucormycetes The molecular identification was correlated with results from histological examination...
November 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27562696/antifungal-susceptibilities-of-non-aspergillus-filamentous-fungi-causing-invasive-infection-in-australia-support-for-current-antifungal-guideline-recommendations
#19
Catriona L Halliday, Sharon C-A Chen, Sarah E Kidd, Sebastian van Hal, Belinda Chapman, Christopher H Heath, Andie Lee, Karina J Kennedy, Kathryn Daveson, Tania C Sorrell, C Orla Morrissey, Deborah J Marriott, Monica A Slavin
Antifungal susceptibilities of non-Aspergillus filamentous fungal pathogens cannot always be inferred from their identification. Here we determined, using the Sensititre(®) YeastOne(®) YO10 panel, the in vitro activities of nine antifungal agents against 52 clinical isolates of emergent non-Aspergillus moulds representing 17 fungal groups in Australia. Isolates comprised Mucorales (n = 14), Scedosporium/Lomentospora spp. (n = 18) and a range of hyaline hyphomycetes (n = 9) and other dematiaceous fungi (n = 11)...
October 2016: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/27485921/cyclophilin-and-enolase-are-the-most-prevalent-conidial-antigens-of-lomentospora-prolificans-recognized-by-healthy-human-salivary-iga-and-cross-react-with-aspergillus-fumigatus
#20
Idoia Buldain, Andoni Ramirez-Garcia, Aize Pellon, Aitziber Antoran, Maria Jesus Sevilla, Aitor Rementeria, Fernando L Hernando
PURPOSE: The study of the immunocompetent airways immune response may provide important information to improve the therapeutic efficacy against Lomentospora (Scedosporium) prolificans. So, this study aimed to identify the most prevalent conidial antigens of this multiresistant fungus recognized by healthy human salivary immunoglobulin A, and to study their expression and cross-reactivity with other fungal species. EXPERIMENTAL DESIGN: Twenty saliva from immunocompetent donors were used to detect and identify the immunoreactive proteins by 2D immunoblotting and LC-MS/MS...
October 2016: Proteomics. Clinical Applications
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