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Scedosporium apiospermum

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https://www.readbyqxmd.com/read/29924142/scedosporium-apiospermum-scedosporium-aurantiacum-scedosporium-minutisporum-and-lomentospora-prolificans-a-comparative-study-of-surface-molecules-produced-by-conidial-and-germinated-conidial-cells
#1
Thaís Pereira de Mello, Ana Carolina Aor, Diego de Souza Gonçalves, Sergio Henrique Seabra, Marta Helena Branquinha, André Luis Souza Dos Santos
BACKGROUND Scedosporium/Lomentospora species are opportunistic mould pathogens, presenting notable antifungal resistance. OBJECTIVES/METHODS We analysed the conidia and germinated conidia of S. apiospermum (Sap), S. aurantiacum (Sau), S. minutisporum (Smi) and L. prolificans (Lpr) by scanning electron microscopy and exposition of surface molecules by fluorescence microscopy. FINDINGS Conidia of Sap, Smi and Sau had oval, ellipsoidal and cylindrical shape, respectively, with several irregularities surrounding all surface areas, whereas Lpr conidia were rounded with a smooth surface...
2018: Memórias do Instituto Oswaldo Cruz
https://www.readbyqxmd.com/read/29891611/identification-of-14-alpha-lanosterol-demethylase-cyp51-in-scedosporium-species
#2
Anne Bernhardt, Wieland Meyer, Volker Rickerts, Toni Aebischer, Kathrin Tintelnot
Scedosporium spp. cause infections (scedosporiosis) in both immunocompetent and immunocompromised individuals and may persistently colonise the respiratory tract in patients with cystic fibrosis (CF). They are less susceptible against azoles when compared with other moulds such as Aspergillus , suggesting the presence of resistance mechanisms. It can be hypothesised that the decreased susceptibility of Scedosporium spp. to azoles is also CYP51 dependant. Analysis of the S. apiospermum and S. aurantiacum genome revealed one CYP51 gene encoding the 14 alpha-lanosterol demethylase...
June 11, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29889264/transcriptional-profiling-of-scedosporium-apiospermum-enzymatic-antioxidant-gene-battery-unravels-the-involvement-of-thioredoxin-reductases-against-chemical-and-phagocytic-cells-oxidative-stress
#3
Cindy Staerck, Julie Tabiasco, Charlotte Godon, Yves Delneste, Jean-Philippe Bouchara, Maxime J J Fleury
Scedosporium species rank the second, after Aspergillus fumigatus, among the filamentous fungi colonizing the airways of patients with cystic fibrosis (CF). Development of microorganisms in the respiratory tract depends on their capacity to evade killing by the host immune system, particularly through the oxidative response of macrophages and neutrophils, with the release of reactive oxygen species (ROS) and reactive nitrogen species (RNS). This is particularly true in the airways of CF patients which display an exacerbated inflammatory reaction...
June 8, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29887928/skull-base-osteomyelitis-secondary-to-scedosporium-apiospermum-infection
#4
Martin Doss, David Doss
Scedosporium apiospermum is a common environmental mold which is increasingly reported in the literature as a cause of infection, particularly in the immunocompromised patient population. We present a case of malignant otitis externa due to S apiospermum , complicated by spread of infection causing skull base osteomyelitis, internal carotid artery vasculitis and subsequent stroke. Despite the multiple complications encountered, prompt diagnosis and initiation of appropriate antifungal treatment resulted in patient survival...
August 2018: Radiology Case Reports
https://www.readbyqxmd.com/read/29755443/genomic-organization-and-expression-of-iron-metabolism-genes-in-the-emerging-pathogenic-mold-scedosporium-apiospermum
#5
Yohann Le Govic, Nicolas Papon, Solène Le Gal, Bénédicte Lelièvre, Jean-Philippe Bouchara, Patrick Vandeputte
The ubiquitous mold Scedosporium apiospermum is increasingly recognized as an emerging pathogen, especially among patients with underlying disorders such as immunodeficiency or cystic fibrosis (CF). Indeed, it ranks the second among the filamentous fungi colonizing the respiratory tract of CF patients. However, our knowledge about virulence factors of this fungus is still limited. The role of iron-uptake systems may be critical for establishment of Scedosporium infections, notably in the iron-rich environment of the CF lung...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29750016/spotlight-on-isavuconazole-in-the-treatment-of-invasive-aspergillosis-and-mucormycosis-design-development-and-place-in-therapy
#6
REVIEW
Jeffrey D Jenks, Helmut Jf Salzer, Juergen Prattes, Robert Krause, Dieter Buchheidt, Martin Hoenigl
In recent decades, important advances have been made in the diagnosis and treatment of invasive aspergillosis (IA) and mucormycosis. One of these advances has been the introduction of isavuconazole, a second-generation broad spectrum triazole with a favorable pharmacokinetic and safety profile and few drug-drug interactions. Phase III trials in patients with IA and mucormycosis demonstrated that isavuconazole has similar efficacy to voriconazole for the treatment of IA (SECURE trial) and liposomal amphotericin B for the treatment of mucormycosis (VITAL trial with subsequent case-control analysis) and a favorable safety profile with significantly fewer ocular, hepatobiliary, and skin and soft tissue adverse events compared to voriconazole...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29735424/direct-in-vitro-comparison-of-the-prodrug-isavuconazonium-sulfate-with-the-isavuconazole-active-compound-against-aspergillus-spp-and-2-rare-moulds
#7
Michael A Pfaller, Paul R Rhomberg, Mariana Castanheira
Isavuconazonium sulfate is a prodrug of isavuconazole, a broad-spectrum mould-active triazole antifungal drug. We provide a direct comparison of the in vitro activity of the prodrug versus the active metabolite against clinical isolates of Aspergillus spp., Sarocladium kiliense, and Scedosporium apiospermum using CLSI broth microdilution methods. The MIC values obtained for the prodrug were one 2-fold dilution higher than those of isavuconazole for all isolates tested. Using previously defined epidemiological cutoff values for isavuconazole and Aspergillus spp...
April 13, 2018: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/29579888/severe-scedosporium-apiospermum-infection-in-a-recent-renal-transplant-recipient-case-report
#8
M J Torres-Sánchez, E Hernández-García, J Gómez-Sánchez, M Palomares-Bayo, M Peña-Ortega, P Galindo-Sacristán, C De Gracia-Guindo, A Osuna-Ortega
Infections in transplanted patients are still an important cause of morbidity and mortality. Among them, fungal infections with pathogens have become increasingly more prevalent in the last decade. We report the clinical course and management of disseminated Scedosporium apiospermum infection in a kidney transplant recipient, with microbiological isolation of the fungus in cerebrospinal fluid culture. S apiospermum is a fungus that is distributed worldwide and can be grown from soil samples or stagnant water...
March 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29554296/the-diagnosis-and-management-of-respiratory-tract-fungal-infection-in-cystic-fibrosis-a-uk-survey-of-current-practice
#9
M Boyle, J E Moore, J L Whitehouse, D Bilton, D G Downey
Aspergillus fumigatus is commonly found in the airways of patients with cystic fibrosis (CF), and allergic bronchopulmonary aspergillosis (ABPA) is the most recognized associated clinical condition. However, accurate diagnosis remains challenging, and there is a paucity of clinical trials to guide clinical management of fungal disease. The aim of this survey was to assess the variability in current practice across the UK in diagnosis and management of fungal lung disease in CF patients. A 21 question anonymous online survey was sent to 94 paediatric and adult CF consultants in the UK...
March 15, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29494271/molecular-identification-and-in-vitro-antifungal-susceptibility-of-scedosporium-complex-isolates-from-high-human-activity-sites-in-mexico
#10
Mariana Elizondo-Zertuche, Rogelio de J Treviño-Rangel, Efrén Robledo-Leal, Carolina E Luna-Rodríguez, Margarita L Martínez-Fierro, Iram P Rodríguez-Sánchez, Gloria M González
The genus Scedosporium is a complex of ubiquitous moulds associated with a wide spectrum of clinical entities, with high mortality principally in immunocompromised hosts. Ecology of these microorganisms has been studied performing isolations from environmental sources, showing a preference for human-impacted environments. This study aimed to evaluate the presence and antifungal susceptibility of Scedosporium complex species in soil samples collected in high-human-activity sites of Mexico. A total of 97 soil samples from 25 Mexican states were collected...
2017: Mycologia
https://www.readbyqxmd.com/read/29433463/scedosporium-apiospermum-infectious-scleritis-following-posterior-subtenon-triamcinolone-acetonide-injection-a-case-report-and-literature-review
#11
REVIEW
Daisuke Todokoro, Junki Hoshino, Ayaka Yo, Koichi Makimura, Junko Hirato, Hideo Akiyama
BACKGROUND: Ubiquitous fungi of the Scedosporium apiospermum species complex (SASC) cause various opportunistic infections. Posterior subtenon triamcinolone acetonide (STTA) injection is a standard therapy for intraocular inflammation and macular edema. We report a case of Scedosporium apiospermum infectious scleritis after a posterior STTA injection. CASE PRESENTATION: A 75-year-old man received a posterior STTA injection to treat macular edema in his left eye...
February 13, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29426208/tannery-mixed-liquors-from-an-ecotoxicological-and-mycological-point-of-view-risks-vs-potential-biodegradation-application
#12
Valeria Tigini, Federico Bevione, Valeria Prigione, Anna Poli, Lucrezia Ranieri, Francesco Spennati, Giulio Munz, Giovanna Cristina Varese
Fungi are known to be present in the activated sludge of wastewater treatment plants (WWTP). Their study should be at the base of an overall vision of the plant effectiveness and of effluents sanitary impact. Moreover, it could be fundamental for the implementation of successful bioaugmentation strategies aimed at the removal of recalcitrant or toxic compounds. This is one of the first studies on the cultivable autochthonous mycoflora present in the mixed liquors of two WWTP treating either vegetable or chromium tannery effluents...
June 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29370408/in-vitro-activity-of-the-novel-antifungal-compound-f901318-against-australian-scedosporium-and-lomentospora-fungi
#13
Chayanika Biswas, Derek Law, Michael Birch, Catriona Halliday, Tania C Sorrell, John Rex, Monica Slavin, Sharon C-A Chen
We determined the in vitro activity of the novel orotomide antifungal, F901318, against 30 Lomentospora prolificans, 20 Scedosporium apiospermum, 7 S. aurantiacum, and 3 S. boydii, isolates in comparison with standard antifungals. Against L. prolificans, F901318 was the most potent compound (MIC90 0.25 μg/ml); the geometric mean MIC (0.26 μg/ml) was significantly lower (23-80-fold) than those of itraconazole, voriconazole, posaconazole, and isavuconazole (all P < .001), and amphotericin B (P < .05)...
January 22, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29323071/-scedosporium-apiospermum-an-emerging-pathogen-in-india-case-series-and-review-of-literature
#14
Dabet Rynga, Malini R Capoor, Swati Varshney, Mayuresh Naik, V Gupta
Scedosporium apiospermum is a rare cause of infection but is increasingly being reported among immunocompromised individuals around the world. We report two cases of S. apiospermum, one of keratitis and the other of nasal polyp both from immunocompetent patients. The two cases were successfully treated with voriconazole. It is important to diagnose such infections as their antifungal susceptibility to amphotericin B is variable.
October 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29283143/ocular-infections-caused-by-scedosporium-apiospermum-a-case-series
#15
Seema Ramakrishnan, Kunal Mandlik, Tejashree Sanket Sathe, Joseph Gubert, Thiruvengada Krishnan, Prabu Baskaran
The aim of our retrospective study is to report a case series of ocular infections caused by a rare fungus, Scedosporium apiospermum, in a South Indian population. Thirteen cases of culture-positive S. apiospermum infections diagnosed between January 2011 and March 2016 were included in this study. The parameters evaluated were predisposing factors, treatment and final clinical outcome. The most common mode of presentation was keratitis (84.6%) followed by sclerokeratitis (15.3%). The predisposing factors involved were unspecified foreign body injury (30...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29274090/case-of-femoral-pseudarthrosis-due-to-scedosporium-apiospermum-in-an-immunocompetent-patient-with-successful-conservative-treatment-and-review-of-literature
#16
Aurélien Dinh, Olivier Demay, Martin Rottman, Fabrice Gaudot, Marie-Elisabeth Bougnoux, Frédérique Bouchand, Hélène Coignard, Claire Rouzaud, Benjamin Davido, Clara Duran, Christophe Nich
Scedosporium apiospermum is a ubiquitous filamentous fungus, commonly found in soil, sewage and polluted waters. It is rarely pathogenic but can cause a broad spectrum of clinical diseases, which can be localised or disseminate to distant organs. The disseminated form of the disease is mostly seen among immunocompromised patients. However, some rare cases of disseminated disease have been reported in immunocompetent individuals. Treatment of these infections is challenging because of their natural resistance to many antifungal agents...
December 23, 2017: Mycoses
https://www.readbyqxmd.com/read/29228273/direct-detection-of-exophiala-and-scedosporium-species-in-sputa-of-patients-with-cystic-fibrosis
#17
Min Chen, Nahid Kondori, Shuwen Deng, A H G Gerrits van den Ende, M Lackner, Wanqing Liao, G S de Hoog
Detection of species of Exophiala and Scedosporium in the respiratory tracts of cystic fibrosis (CF) patients remains controversial because of highly variable results. The results of our study suggested a significantly higher prevalence and more complex colonization than previously estimated. Approximately 17% (27/162) of clinical sputum samples were found to be positive for Exophiala dermatitidis and 30% (49/162) were positive for Scedosporium apiospermum / S. boydii species complex determined by reverse line blot (RLB) hybridization...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29225727/the-genomic-study-of-an-environmental-isolate-of-scedosporium-apiospermum-shows-its-metabolic-potential-to-degrade-hydrocarbons
#18
Laura T Morales, Laura N González-García, María C Orozco, Silvia Restrepo, Martha J Vives
Crude oil contamination of soils and waters is a worldwide problem, which has been actively addressed in recent years. Sequencing genomes of microorganisms involved in the degradation of hydrocarbons have allowed the identification of several promoters, genes, and degradation pathways of these contaminants. This knowledge allows a better understanding of the functional dynamics of microbial degradation. Here, we report a first draft of the 44.2 Mbp genome assembly of an environmental strain of the fungus Scedosporium apiospermum...
2017: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/29116676/salvage-therapy-with-topical-posaconazole-in-lung-transplant-recipients-with-invasive-scedosporium-infection
#19
Amparo Solé, Ana A García-Robles, Carlos Jordá, Enrique Cases Viedma, Nuria Mancheño, José Luis Poveda-Andrés, Juan Pablo Reig Mezquida, Javier Pemán
Scedosporium is an important pathogen in cystic fibrosis (CF) and post-transplantation, but it rarely causes invasive infection. Treatment remains challenging, particularly due to the inherent resistance to multiple antifungal agents. We present 3 complicated invasive tracheobronchial and lung Scedosporium apiospermum infections following lung transplantation. In 2 of 3 cases, the infection was clinically and radiologically cured with frequent cleansing bronchoscopies, combining triazole with terbinafine therapy and nebulized posaconazole...
February 2018: American Journal of Transplantation
https://www.readbyqxmd.com/read/29111602/scedosporium-apiospermum-infection-of-the-urinary-system-with-a-review-of-treatment-options-and-cases-in-the-literature
#20
Esther Benamu, Alexander Tin-Han Yu, Lijia Xie, Sebastian Fernandez-Pol, Anne Y Liu, Dora Y Ho
Infection with Scedosporium species is associated with a significant morbidity and mortality and is becoming increasingly common, especially in immunocompromised patients. We describe the presentation and successful management of an immunocompromised patient with Scedosporium apiospermum infection of the upper urinary tract system, a rare disease manifestation. The current literature on urinary tract scedosporiosis is further reviewed with emphasis on treatment options and limitations of current antifungal therapy...
February 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
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