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Scedosporium apiospermum

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https://www.readbyqxmd.com/read/28748285/toward-the-standardization-of-mycological-examination-of-sputum-samples-in-cystic-fibrosis-results-from-a-french-multicenter-prospective-study
#1
Noémie Coron, Marc Pihet, Emilie Fréalle, Yolande Lemeille, Claudine Pinel, Hervé Pelloux, Gilles Gargala, Loic Favennec, Isabelle Accoceberry, Isabelle Durand-Joly, Frédéric Dalle, Frédéric Huet, Annlyse Fanton, Amale Boldron, Guy-André Loeuille, Philippe Domblides, Bérengère Coltey, Isabelle Pin, Catherine Llerena, Françoise Troussier, Christine Person, Christophe Marguet, Nathalie Wizla, Caroline Thumerelle, Dominique Turck, Stéphanie Bui, Michael Fayon, Alain Duhamel, Anne Prévotat, Benoit Wallaert, Sylvie Leroy, Jean-Philippe Bouchara, Laurence Delhaes
Fungal respiratory colonization of cystic fibrosis (CF) patients emerges as a new concern; however, the heterogeneity of mycological protocols limits investigations. We first aimed at setting up an efficient standardized protocol for mycological analysis of CF sputa that was assessed during a prospective, multicenter study: "MucoFong" program (PHRC-06/1902). Sputa from 243 CF patients from seven centers in France were collected over a 15-month period and submitted to a standardized protocol based on 6 semi-selective media...
July 26, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28704511/genetic-variation-analysis-and-relationships-among-environmental-strains-of-scedosporium-apiospermum-sensu-stricto-in-bangkok-thailand
#2
Thanwa Wongsuk, Potjaman Pumeesat, Natthanej Luplertlop
The Scedosporium apiospermum species complex is an emerging filamentous fungi that has been isolated from environment. It can cause a wide range of infections in both immunocompetent and immunocompromised individuals. We aimed to study the genetic variation and relationships between 48 strains of S. apiospermum sensu stricto isolated from soil in Bangkok, Thailand. For PCR, sequencing and phylogenetic analysis, we used the following genes: actin; calmodulin exons 3 and 4; the second largest subunit of the RNA polymerase II; ß-tubulin exon 2-4; manganese superoxide dismutase; internal transcribed spacer; transcription elongation factor 1α; and beta-tubulin exons 5 and 6...
2017: PloS One
https://www.readbyqxmd.com/read/28699395/scedosporium-apiospermum-infection-lethal-complication-after-extracorporeal-cardiopulmonary-resuscitation
#3
Yong Mei, Xufeng Chen, Kai Sun, Jinru Lv, Hao Sun, Jinsong Zhang
In recent years, the development of extracorporeal membrane oxygenation (ECMO) technology has led to its extensive use in clinical practice. In particular, ECMO can play an important role in cardiopulmonary resuscitation (CPR). The American Heart Association CPR guidelines recommend its use in patients with cardiac arrest due to reversible disorders, along with high-quality CPR. This is called extracorporeal cardiopulmonary resuscitation (ECPR). However, it is important to be aware of the possibility of infection-related complications...
July 1, 2017: Perfusion
https://www.readbyqxmd.com/read/28649485/scedosporium-apiospermum-brain-abscesses-in-a-patient-after-near-drowning-a-case-report-with-10-year-follow-up-and-a-review-of-the-literature
#4
Sandra C Signore, Christoph P Dohm, Gunther Schütze, Mathias Bähr, Pawel Kermer
Scedosporium apiospermum is known to be a fungal pathogen affecting immunocompromised as well as non-immunodeficient patients. Although this fungus is found rarely, an infection can lead to severe and even fatal disease. Here, we describe the case of a 41-year-old female who developed multiple Scedosporium apiospermum brain abscesses after near-drowning with aspiration of contaminated mud and water. She showed various neurological symptoms. The patient recovered after removal of abscesses in combination with long-term antifungal treatment...
September 2017: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28639066/enzymatic-mechanisms-involved-in-evasion-of-fungi-to-the-oxidative-stress-focus-on-scedosporium-apiospermum
#5
C Staerck, P Vandeputte, A Gastebois, A Calenda, S Giraud, N Papon, J P Bouchara, M J J Fleury
The airways of patients with cystic fibrosis (CF) are frequently colonized by various filamentous fungi, mainly Aspergillus fumigatus and Scedosporium species. To establish within the respiratory tract and cause an infection, these opportunistic fungi express pathogenic factors allowing adherence to the host tissues, uptake of extracellular iron, or evasion to the host immune response. During the colonization process, inhaled conidia and the subsequent hyphae are exposed to reactive oxygen species (ROS) and reactive nitrogen species (RNS) released by phagocytic cells, which cause in the fungal cells an oxidative stress and a nitrosative stress, respectively...
June 21, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28618155/clinical-outcome-of-cystic-fibrosis-patients-colonized-by-scedosporium-species-following-lung-transplantation-a-single-center-15-year-experience
#6
Perrine Parize, Veronique Boussaud, Vianney Poinsignon, Emilie Sitterlé, Francoise Botterel, Sandrine Lefeuvre, Romain Guillemain, Eric Dannaoui, Eliane M Billaud
BACKGROUND: Fungi of the genus Scedosporium are emerging pathogens responsible for severe infections in lung transplant recipients. These infections are associated with poor prognosis and some centers consider now Scedosporium species colonization as a contraindication to lung transplantation (LT) even though no published evidence demonstrates that Scedosporium species colonization is associated with higher morbidity or mortality after LT. METHODS: Here, we aim to describe characteristics and outcome of cystic fibrosis (CF) lung transplant recipients colonized with Scedosporium species in a single center over a 15-year period...
June 15, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/28609568/ultrasonography-of-a-ureteral-and-bladder-fungal-granuloma-caused-by-scedosporium-apiospermum-in-a-basset-hound
#7
Jaya Kochenburger, Christian Eriksson, Marc Greenberg, Laura Hoyt
A 5-year-old, spayed female, Basset Hound was referred for evaluation of a urinary bladder mass. Ultrasonographic images revealed a large, inhomogeneous, hypoechoic mass associated with the dorsal wall of the neck of the urinary bladder and left ureter. Partial cystectomy and left ureteral reimplantation were performed. Histopathology showed a severe inflammatory mass lesion forming multiple granulomas. A DNA sequencing test revealed Scedosporium apiospermum as the causative agent. Susceptibility tests on the isolated strain indicated susceptibility to voriconazole...
June 13, 2017: Veterinary Radiology & Ultrasound
https://www.readbyqxmd.com/read/28504471/scedosporium-apiospermum-complex-in-cystic-fibrosis-should-we-treat
#8
Maria Noni, Anna Katelari, Aikaterini Kapi, Angeliki Stathi, George Dimopoulos, Stavros-Eleftherios Doudounakis
Species of the Scedosporium apiospermum complex are the second most frequent filamentous fungi after Aspergillus fumigatus that can be found in cystic fibrosis (CF). Mixed colonisation by S. apiospermum complex and A. fumigatus is also quite common. In this study we summarise all CF patients who were colonised by S. apiospermum complex during their childhood and we present two CF patients who were treated as fungal bronchitis due to S. apiospermum complex. The medical records of 400 CF patients were reviewed in order to identify those with positive respiratory cultures for S...
May 15, 2017: Mycoses
https://www.readbyqxmd.com/read/28410611/recurrent-scedosporium-apiospermum-mycetoma-successfully-treated-by-surgical-excision-and-terbinafine-treatment-a-case-report-and-review-of-the-literature
#9
Eszter J Tóth, Géza R Nagy, Mónika Homa, Marianna Ábrók, Ildikó É Kiss, Gábor Nagy, Zsuzsanna Bata-Csörgő, Lajos Kemény, Edit Urbán, Csaba Vágvölgyi, Tamás Papp
BACKGROUND: Scedosporium apiospermum is an emerging opportunistic filamentous fungus, which is notorious for its high levels of antifungal-resistance. It is able to cause localized cutaneous or subcutaneous infections in both immunocompromised and immunocompetent persons, pulmonary infections in patients with predisposing pulmonary diseases and invasive mycoses in immunocompromised patients. Subcutaneous infections caused by this fungus frequently show chronic mycetomatous manifestation...
April 14, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28333310/dihydroorotate-dehydrogenase-inhibitor-f901318-has-potent-in-vitro-activity-against-scedosporium-species-and-lomentospora-prolificans
#10
Nathan P Wiederhold, Derek Law, Michael Birch
Background: Scedosporium species and Lomentospora prolificans are increasing causes of invasive infections in immunocompromised hosts and many isolates are resistant to available antifungals. Our objective was to assess the in vitro potency of F901318, a member of the orotomide class of antifungals, against Scedosporium species and L. prolificans . Methods: The in vitro potency of F901318 was evaluated against 66 Scedosporium and 7 L. prolificans clinical isolates using the CLSI M38-A2 reference standard...
March 15, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28329186/fatal-bilateral-haemopneumothoraces-following-double-lung-transplantation-caused-by-pretransplant-colonization-by-scedosporium-apiospermum
#11
Francisco Javier Gonzalez-Garcia, Julia Guzman-Puche, Javier Redel-Montero, Paula Moreno
No abstract text is available yet for this article.
June 1, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28276198/anthropogenic-impact-on-environmental-filamentous-fungi-communities-along-the-mediterranean-littoral
#12
Mohammed Hashim Al-Yasiri, Anne-Cécile Normand, Jean-François Mauffrey, Stéphane Ranque
We hypothesised that anthropogenic influences impact the filamentous fungi community structure and that particular species or species patterns might serve as markers to characterise ecosystems. This study aimed to describe the filamentous fungi community structure in various biotopes along the Mediterranean shore that were exposed to various levels of anthropogenic influence. We sampled filamentous fungi from yellow-legged gull faecal samples at five study sites along the Mediterranean littoral in southern France...
March 9, 2017: Mycoses
https://www.readbyqxmd.com/read/28272067/prompt-diagnosis-of-scedosporium-apiospermum-soft-tissue-infection-life-saving-in-a-renal-transplant-recipient
#13
R Ghosh, P Mishra, P K Maiti, A Debnandi
Scedosporium apiospermum, an ubiquitous filamentous fungus, a known cause of mycetoma, is emerging as an opportunistic pathogen in immunocompromised individuals. We report a case of painful foot abscess in a renal allograft recipient on immunosuppressive therapy, which was clinically diagnosed as a suppurative bacterial abscess. Pus was aspirated, which showed septate, branching hyphal elements and culture on Sabouraud's dextrose agar yielded S. apiospermum, which was identified based on its macroscopic and microscopic features...
July 2017: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/28223376/bactericidal-and-fungicidal-activity-of-n-chlorotaurine-is-enhanced-in-cystic-fibrosis-sputum-medium
#14
Martina Gruber, Ivan Moser, Markus Nagl, Michaela Lackner
Lung infections with multiresistant pathogens are a major problem among patients suffering from cystic fibrosis (CF). N-Chlorotaurine (NCT), a microbicidal active chlorine compound with no development of resistance, is well tolerated upon inhalation. The aim of this study was to investigate the in vitro bactericidal and fungicidal activity of NCT in artificial sputum medium (ASM), which mimics the composition of CF mucus. The medium was inoculated with bacteria (Staphylococcus aureus, including some methicillin-resistant S...
May 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28192433/review-of-21-cases-of-mycetoma-from-1991-to-2014-in-rio-de-janeiro-brazil
#15
Felipe Maurício Soeiro Sampaio, Bodo Wanke, Dayvison Francis Saraiva Freitas, Janice Mery Chicarino de Oliveira Coelho, Maria Clara Gutierrez Galhardo, Marcelo Rosandiski Lyra, Maria Cristina da Silva Lourenço, Rodrigo de Almeida Paes, Antonio Carlos Francesconi do Valle
Mycetoma is caused by the subcutaneous inoculation of filamentous fungi or aerobic filamentous bacteria that form grains in the tissue. The purpose of this study is to describe the epidemiologic, clinic, laboratory, and therapeutic characteristics of patients with mycetoma at the Oswaldo Cruz Foundation in Rio de Janeiro, Brazil, between 1991 and 2014. Twenty-one cases of mycetoma were included in the study. There was a predominance of male patients (1.3:1) and the average patient age was 46 years. The majority of the cases were from the Southeast region of Brazil and the feet were the most affected anatomical region (80...
February 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28178337/prospective-multicenter-german-study-on-pulmonary-colonization-with-scedosporium-lomentospora-species-in-cystic-fibrosis-epidemiology-and-new-association-factors
#16
MULTICENTER STUDY
Carsten Schwarz, Claudia Brandt, Elisabeth Antweiler, Alexander Krannich, Doris Staab, Sabina Schmitt-Grohé, Rainald Fischer, Dominik Hartl, Anja Thronicke, Kathrin Tintelnot
BACKGROUND: An increasing rate of respiratory colonization and infection in cystic fibrosis (CF) is caused by fungi of the Scedosporium apiospermum species complex or Lomentospora prolificans (Sac-Lp). These fungi rank second among the filamentous fungi colonizing the CF airways, after Aspergillus fumigatus. However, the epidemiology, clinical relevance and risk of pulmonary colonization with Sac-Lp are rarely understood in CF. The objective of the present prospective multicenter study was to study pathogen distribution and determine association factors of pulmonary Sac-Lp colonization in patients with CF...
2017: PloS One
https://www.readbyqxmd.com/read/28115402/surgical-resection-of-a-rare-cutaneous-manifestation-of-scedosporium-apiospermum-in-a-patient-who-underwent-renal-transplant
#17
A C S Stoneham, S E Stoneham, S A Wyllie, A N Pandya
A man aged 47 years who was immunosuppressed following renal transplantation for focal segmental glomerulosclerosis was referred to the Plastic Surgery team for management of a painful, chronic, granulomatous lesion of the right forearm. Serial ultrasound scans and MRI scans were not diagnostic, but microbiological specimens tested positive for the fungus Scedosporium apiospermum The renal transplant graft-which was failing-was removed, allowing him to cease immunosuppression. He then underwent a resection of the lesion and reconstruction with a split thickness skin graft...
January 23, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28088169/tenosynovitis-caused-by-scedosporium-apiospermum-infection-misdiagnosed-as-an-alternaria-species-a-case-report
#18
Choon-Mee Kim, Sung-Chul Lim, Joa Kim, Hoe-Soo Jang, Jong-Hun Chung, Na-Ra Yun, Dong-Min Kim, Piyush Jha, Babita Jha, Seok Won Kim, Sook Jin Jang, Jong Hee Shin
BACKGROUND: Scedosporium apiospermum, which can usually be isolated from soil, polluted stream water and decaying vegetation, is increasingly recognized as an opportunistic dematiaceous fungus. The mortality rate of infection in immunocompromised hosts is over 50%. S. apiospermum is commonly responsible for dermal and epidermal infections (i.e., mycetoma) after traumatic penetration. CASE PRESENTATION: A 73-year-old woman was admitted to our hospital complaining of painful swelling and tenderness on the dorsum of the proximal left wrist and hand...
January 14, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28053848/rapid-development-of-a-mycotic-aneurysm-of-the-intracranial-artery-secondary-to-scedosporium-apiospermum-sinusitis
#19
Yoshihiko Ogawa, Masatoshi Sato, Masato Tashiro, Masayuki Miyazaki, Kiyoshi Nagata, Nobuyuki Takahashi, Kei Kasahara, Koichi Izumikawa, Hisakazu Yano, Keiichi Mikasa
An 85-year-old man complained of a 2-month history of pain on the left side of his face. Brain computed tomography (CT) and magnetic resonance imaging/magnetic resonance angiography did not clearly show any intracranial abnormality and only showed fluid effusion in his left sphenoid sinus. Filamentous fungi were detected from the left sphenoid sinus specimen. The isolate was Scedosporium apiospermum. He was empirically treated with voriconazole, to which the isolate was susceptible. His consciousness decreased rapidly...
December 2016: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/28035880/scedosporium-apiospermum-mycetoma-in-an-immunocompetent-patient-without-prior-lung-disease
#20
Kevin C Ma, Alejandro Pino, Navneet Narula, Meredith L Turetz
No abstract text is available yet for this article.
January 2017: Annals of the American Thoracic Society
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