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Scedosporium apiospermum

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https://www.readbyqxmd.com/read/29433463/scedosporium-apiospermum-infectious-scleritis-following-posterior-subtenon-triamcinolone-acetonide-injection-a-case-report-and-literature-review
#1
REVIEW
Daisuke Todokoro, Junki Hoshino, Ayaka Yo, Koichi Makimura, Junko Hirato, Hideo Akiyama
BACKGROUND: Ubiquitous fungi of the Scedosporium apiospermum species complex (SASC) cause various opportunistic infections. Posterior subtenon triamcinolone acetonide (STTA) injection is a standard therapy for intraocular inflammation and macular edema. We report a case of Scedosporium apiospermum infectious scleritis after a posterior STTA injection. CASE PRESENTATION: A 75-year-old man received a posterior STTA injection to treat macular edema in his left eye...
February 13, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29426208/tannery-mixed-liquors-from-an-ecotoxicological-and-mycological-point-of-view-risks-vs-potential-biodegradation-application
#2
Valeria Tigini, Federico Bevione, Valeria Prigione, Anna Poli, Lucrezia Ranieri, Francesco Spennati, Giulio Munz, Giovanna Cristina Varese
Fungi are known to be present in the activated sludge of wastewater treatment plants (WWTP). Their study should be at the base of an overall vision of the plant effectiveness and of effluents sanitary impact. Moreover, it could be fundamental for the implementation of successful bioaugmentation strategies aimed at the removal of recalcitrant or toxic compounds. This is one of the first studies on the cultivable autochthonous mycoflora present in the mixed liquors of two WWTP treating either vegetable or chromium tannery effluents...
February 2, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29370408/in-vitro-activity-of-the-novel-antifungal-compound-f901318-against-australian-scedosporium-and-lomentospora-fungi
#3
Chayanika Biswas, Derek Law, Michael Birch, Catriona Halliday, Tania C Sorrell, John Rex, Monica Slavin, Sharon C-A Chen
We determined the in vitro activity of the novel orotomide antifungal, F901318, against 30 Lomentospora prolificans, 20 Scedosporium apiospermum, 7 S. aurantiacum, and 3 S. boydii, isolates in comparison with standard antifungals. Against L. prolificans, F901318 was the most potent compound (MIC90 0.25 μg/ml); the geometric mean MIC (0.26 μg/ml) was significantly lower (23-80-fold) than those of itraconazole, voriconazole, posaconazole, and isavuconazole (all P < .001), and amphotericin B (P < .05)...
January 22, 2018: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29323071/scedosporium-apiospermum-an-emerging-pathogen-in-india-case-series-and-review-of-literature
#4
Dabet Rynga, Malini R Capoor, Swati Varshney, Mayuresh Naik, V Gupta
Scedosporium apiospermum is a rare cause of infection but is increasingly being reported among immunocompromised individuals around the world. We report two cases of S. apiospermum, one of keratitis and the other of nasal polyp both from immunocompetent patients. The two cases were successfully treated with voriconazole. It is important to diagnose such infections as their antifungal susceptibility to amphotericin B is variable.
October 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29283143/ocular-infections-caused-by-scedosporium-apiospermum-a-case-series
#5
Seema Ramakrishnan, Kunal Mandlik, Tejashree Sanket Sathe, Joseph Gubert, Thiruvengada Krishnan, Prabu Baskaran
The aim of our retrospective study is to report a case series of ocular infections caused by a rare fungus, Scedosporium apiospermum, in a South Indian population. Thirteen cases of culture-positive S. apiospermum infections diagnosed between January 2011 and March 2016 were included in this study. The parameters evaluated were predisposing factors, treatment and final clinical outcome. The most common mode of presentation was keratitis (84.6%) followed by sclerokeratitis (15.3%). The predisposing factors involved were unspecified foreign body injury (30...
January 2018: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29274090/case-of-femoral-pseudarthrosis-due-to-scedosporium-apiospermum-in-an-immunocompetent-patient-with-successful-conservative-treatment-and-review-of-literature
#6
Aurélien Dinh, Olivier Demay, Martin Rottman, Fabrice Gaudot, Marie-Elisabeth Bougnoux, Frédérique Bouchand, Hélène Coignard, Claire Rouzaud, Benjamin Davido, Clara Duran, Christophe Nich
Scedosporium apiospermum is a ubiquitous filamentous fungus, commonly found in soil, sewage, and polluted waters. It is rarely pathogenic but can cause a broad spectrum of clinical diseases, which can be localized or disseminate to distant organs. The disseminated form of the disease is mostly seen among immunocompromised patients. However, some rare cases of disseminated disease have been reported in immunocompetent individuals. Treatment of these infections is challenging because of their natural resistance to many antifungal agents...
December 23, 2017: Mycoses
https://www.readbyqxmd.com/read/29228273/direct-detection-of-exophiala-and-scedosporium-species-in-sputa-of-patients-with-cystic-fibrosis
#7
Min Chen, Nahid Kondori, Shuwen Deng, A H G Gerrits van den Ende, M Lackner, Wanqing Liao, G S de Hoog
Detection of species of Exophiala and Scedosporium in the respiratory tracts of cystic fibrosis (CF) patients remains controversial because of highly variable results. The results of our study suggested a significantly higher prevalence and more complex colonization than previously estimated. Approximately 17% (27/162) of clinical sputum samples were found to be positive for Exophiala dermatitidis and 30% (49/162) were positive for Scedosporium apiospermum / S. boydii species complex determined by reverse line blot (RLB) hybridization...
December 8, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29225727/the-genomic-study-of-an-environmental-isolate-of-scedosporium-apiospermum-shows-its-metabolic-potential-to-degrade-hydrocarbons
#8
Laura T Morales, Laura N González-García, María C Orozco, Silvia Restrepo, Martha J Vives
Crude oil contamination of soils and waters is a worldwide problem, which has been actively addressed in recent years. Sequencing genomes of microorganisms involved in the degradation of hydrocarbons have allowed the identification of several promoters, genes, and degradation pathways of these contaminants. This knowledge allows a better understanding of the functional dynamics of microbial degradation. Here, we report a first draft of the 44.2 Mbp genome assembly of an environmental strain of the fungus Scedosporium apiospermum...
2017: Standards in Genomic Sciences
https://www.readbyqxmd.com/read/29116676/salvage-therapy-with-topical-posaconazole-in-lung-transplant-recipients-with-invasive-scedosporium-infection
#9
Amparo Solé, Ana A García-Robles, Carlos Jordá, Enrique Cases Viedma, Nuria Mancheño, José Luis Poveda-Andrés, Juan Pablo Reig Mezquida, Javier Pemán
Scedosporium is an important pathogen in cystic fibrosis (CF) and post-transplantation, but it rarely causes invasive infection. Treatment remains challenging, particularly due to the inherent resistance to multiple antifungal agents. We present 3 complicated invasive tracheobronchial and lung Scedosporium apiospermum infections following lung transplantation. In 2 of 3 cases, the infection was clinically and radiologically cured with frequent cleansing bronchoscopies, combining triazole with terbinafine therapy and nebulized posaconazole...
November 8, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29111602/scedosporium-apiospermum-infection-of-the-urinary-system-with-a-review-of-treatment-options-and-cases-in-the-literature
#10
Esther Benamu, Alexander Tin-Han Yu, Lijia Xie, Sebastian Fernandez-Pol, Anna Y Liu, Dora Y Ho
Infection with Scedosporium species is associated with significant morbidity and mortality and is becoming increasingly common, especially in immunocompromised patients. We describe the presentation and successful management of an immunocompromised patient with Scedosporium apiospermum infection of the upper urinary tract system, a rare disease manifestation. The current literature on urinary tract scedosporiosis is further reviewed with emphasis on treatment options and limitations of current antifungal therapy...
November 7, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29074141/bullous-necrotic-purpura-caused-by-scedosporium-apiospermum-presenting-with-a-sporotrichoid-pattern
#11
J Company-Quiroga, C Martínez-Morán, A Moreno, J Borbujo
No abstract text is available yet for this article.
October 23, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29031652/-scedosporium-apiospermum-skin-infection-mimicking-a-pyoderma-gangrenosum
#12
C Duretz, P Buchlin, A Huguenin, A Durlach, M Hentzien, S Mestrallet, D Lebrun
No abstract text is available yet for this article.
October 11, 2017: Médecine et Maladies Infectieuses
https://www.readbyqxmd.com/read/28974395/scedosporium-boydii-cata1-and-sodc-recombinant-proteins-new-tools-for-serodiagnosis-of-scedosporium-infection-of-patients-with-cystic-fibrosis
#13
Sara Mina, Cindy Staerck, Agnès Marot, Charlotte Godon, Alphonse Calenda, Jean-Philippe Bouchara, Maxime J J Fleury
Scedosporium species rank the second among the filamentous fungi colonizing the airways of patients with cystic fibrosis (CF), after Aspergillus fumigatus. In CF, these fungi may cause various respiratory infections similar to those caused by A. fumigatus, including bronchitis and allergic broncho-pulmonary mycoses. Diagnosis of these infections relies on the detection of serum antibodies using crude antigenic extracts. However, many components of these extracts are common to Scedosporium and Aspergillus species, leading to cross-reactions...
August 26, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28966527/a-case-of-localized-cutaneous-infection-caused-by-scedosporium-apiospermum-presenting-as-cellulitis
#14
Soo Hyeon Noh, Ga Hye Na, Kun Park, Eun Jung Kim
No abstract text is available yet for this article.
October 2017: Annals of Dermatology
https://www.readbyqxmd.com/read/28950832/orbital-apex-syndrome-secondary-to-a-fungal-nasal-septal-abscess-caused-by-scedosporium-apiospermum-in-a-patient-with-uncontrolled-diabetes-a-case-report
#15
Ippei Kishimoto, Shogo Shinohara, Tetsuhiro Ueda, Shoichi Tani, Hajime Yoshimura, Yukihiro Imai
BACKGROUND: Orbital apex syndrome is a localized type of orbital cellulitis, where mass lesions occur at the apex of the cranial nerves. Although nasal septal abscess is uncommon, the organism most likely to cause nasal septal abscess is Staphylococcus aureus, and fungal septal abscesses are rare. Here we present an extremely rare and serious case of orbital apex syndrome secondary to fungal nasal septal abscess caused by Scedosporium apiospermum in a patient with uncontrolled diabetes...
September 26, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28929280/ecology-of-scedosporium-species-present-knowledge-and-future-research
#16
A Rougeron, S Giraud, A Alastruey-Izquierdo, J Cano-Lira, J Rainer, A Mouhajir, S Le Gal, G Nevez, W Meyer, J P Bouchara
The genus Scedosporium, which comprises at least five clinically relevant species, i.e. Scedosporium apiospermum, Scedosporium boydii, Scedosporium aurantiacum, Scedosporium dehoogii and Scedosporium minutisporum, ranks the second among the filamentous fungi colonizing the airways of patients with cystic fibrosis (CF). This colonization of the airways is thought to contribute to the inflammatory reaction leading to a progressive deterioration of the lung function. Additionally, these colonizing fungi may lead to severe disseminated infections in case of lung transplantation...
September 19, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28837349/amino-acid-directed-strategy-for-inducing-the-marine-derived-fungus-scedosporium-apiospermum-f41-1-to-maximize-alkaloid-diversity
#17
Li-Hong Huang, Meng-Yang Xu, Hou-Jin Li, Jin-Qian Li, Yan-Xiu Chen, Wen-Zhe Ma, Yi-Ping Li, Jun Xu, De-Po Yang, Wen-Jian Lan
By feeding various amino acids to the marine fungus Scedosporium apiospermum F41-1, 22 diverse alkaloids, including 14 new compounds, were obtained. Scedapins A-E (1-5) possess a rare skeleton of a pyrazinoquinazolinedione and an imidazoindolone/indolone linked by a tetrahydrofuran ring. Scedapin C (3) is the first example of fumiquinazoline that contains an aminosulfonyl group. Their structures were determined by HRMS, NMR, ECD calculations and X-ray single-crystal diffraction analysis. The biosynthetic pathways of fumiquinazolines 1-18 were proposed...
August 24, 2017: Organic Letters
https://www.readbyqxmd.com/read/28748285/toward-the-standardization-of-mycological-examination-of-sputum-samples-in-cystic-fibrosis-results-from-a-french-multicenter-prospective-study
#18
Noémie Coron, Marc Pihet, Emilie Fréalle, Yolande Lemeille, Claudine Pinel, Hervé Pelloux, Gilles Gargala, Loic Favennec, Isabelle Accoceberry, Isabelle Durand-Joly, Frédéric Dalle, Frédéric Huet, Annlyse Fanton, Amale Boldron, Guy-André Loeuille, Philippe Domblides, Bérengère Coltey, Isabelle Pin, Catherine Llerena, Françoise Troussier, Christine Person, Christophe Marguet, Nathalie Wizla, Caroline Thumerelle, Dominique Turck, Stéphanie Bui, Michael Fayon, Alain Duhamel, Anne Prévotat, Benoit Wallaert, Sylvie Leroy, Jean-Philippe Bouchara, Laurence Delhaes
Fungal respiratory colonization of cystic fibrosis (CF) patients emerges as a new concern; however, the heterogeneity of mycological protocols limits investigations. We first aimed at setting up an efficient standardized protocol for mycological analysis of CF sputa that was assessed during a prospective, multicenter study: "MucoFong" program (PHRC-06/1902). Sputa from 243 CF patients from seven centers in France were collected over a 15-month period and submitted to a standardized protocol based on 6 semi-selective media...
July 26, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28704511/genetic-variation-analysis-and-relationships-among-environmental-strains-of-scedosporium-apiospermum-sensu-stricto-in-bangkok-thailand
#19
Thanwa Wongsuk, Potjaman Pumeesat, Natthanej Luplertlop
The Scedosporium apiospermum species complex is an emerging filamentous fungi that has been isolated from environment. It can cause a wide range of infections in both immunocompetent and immunocompromised individuals. We aimed to study the genetic variation and relationships between 48 strains of S. apiospermum sensu stricto isolated from soil in Bangkok, Thailand. For PCR, sequencing and phylogenetic analysis, we used the following genes: actin; calmodulin exons 3 and 4; the second largest subunit of the RNA polymerase II; ß-tubulin exon 2-4; manganese superoxide dismutase; internal transcribed spacer; transcription elongation factor 1α; and beta-tubulin exons 5 and 6...
2017: PloS One
https://www.readbyqxmd.com/read/28699395/scedosporium-apiospermum-infection-lethal-complication-after-extracorporeal-cardiopulmonary-resuscitation
#20
Yong Mei, Xufeng Chen, Kai Sun, Jinru Lv, Hao Sun, Jinsong Zhang
In recent years, the development of extracorporeal membrane oxygenation (ECMO) technology has led to its extensive use in clinical practice. In particular, ECMO can play an important role in cardiopulmonary resuscitation (CPR). The American Heart Association CPR guidelines recommend its use in patients with cardiac arrest due to reversible disorders, along with high-quality CPR. This is called extracorporeal cardiopulmonary resuscitation (ECPR). However, it is important to be aware of the possibility of infection-related complications...
January 2018: Perfusion
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