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Scedosporium apiospermum

Marina Pekmezovic, Ivana Aleksic, Aleksandra Barac, Valentina Arsic-Arsenijevic, Branka Vasiljevic, Jasmina Nikodinovic-Runic, Lidija Senerovic
Mixed microbial infections caused by Pseudomonas aeruginosa and pathogenic fungi are commonly found in patients with chronic infections and constitute a significant health care burden. The aim of this study was to address the potential polymicrobial antibiofilm activity of pompia and grapefruit essential oils (EOs). The mechanism of antimicrobial activity of EOs was analysed. EOs of pompia and grapefruit inhibited fungal growth with MIC concentrations between 50 and 250 mg L(-1), whereas no effect on P. aeruginosa growth was observed...
November 2016: Pathogens and Disease
Oliver McLaren, Christian Potter
A 79-year-old man, with a history of well-controlled diabetes mellitus, presented with left-sided otalgia. With an initial diagnosis of simple otitis externa, he was discharged on topical drops. He represented 2 months later with worsening otalgia and discharge. A diagnosis of malignant otitis externa was made based on clinical and radiological findings. Intravenous Tazocin and Gentamicin were given based on previous bacterial culture from ear swabs. The patient failed to improve and developed left-sided facial nerve palsy...
2016: BMJ Case Reports
Elham Salehi, Mohammad T Hedayati, Jan Zoll, Haleh Rafati, Maryam Ghasemi, Atosa Doroudinia, Mahdi Abastabar, Ali Tolooe, Eveline Snelders, Henrich A van der Lee, Antonius J M M Rijs, Paul E Verweij, Seyedmojtaba Seyedmousavi, Willem J G Melchers
In a retrospective multicenter study, 102 formalin-fixed paraffin-embedded (FFPE) tissue specimens with histopathology results were tested. Two 4-5 μm FFPE tissue sections from each specimen was digested with proteinase K followed by automated nucleic acid extraction.A specific quantitative real-time quantitative PCR (qPCR) assay targeting the internal transcribed spacer (ITS2) region of ribosomal DNA, using fluorescently labeled primers, was performed to identify clinically important genus and species of Aspergillus, Fusarium, Scedosporium and the Mucormycetes...
September 7, 2016: Journal of Clinical Microbiology
Catriona L Halliday, Sharon C-A Chen, Sarah E Kidd, Sebastian van Hal, Belinda Chapman, Christopher H Heath, Andie Lee, Karina J Kennedy, Kathryn Daveson, Tania C Sorrell, C Orla Morrissey, Deborah J Marriott, Monica A Slavin
Antifungal susceptibilities of non-Aspergillus filamentous fungal pathogens cannot always be inferred from their identification. Here we determined, using the Sensititre(®) YeastOne(®) YO10 panel, the in vitro activities of nine antifungal agents against 52 clinical isolates of emergent non-Aspergillus moulds representing 17 fungal groups in Australia. Isolates comprised Mucorales (n = 14), Scedosporium/Lomentospora spp. (n = 18) and a range of hyaline hyphomycetes (n = 9) and other dematiaceous fungi (n = 11)...
October 2016: International Journal of Antimicrobial Agents
Idoia Buldain, Andoni Ramirez-Garcia, Aize Pellon, Aitziber Antoran, Maria Jesus Sevilla, Aitor Rementeria, Fernando L Hernando
PURPOSE: The study of the immunocompetent airways immune response may provide important information to improve the therapeutic efficacy against Lomentospora (Scedosporium) prolificans. So, this study aimed to identify the most prevalent conidial antigens of this multiresistant fungus recognized by healthy human salivary immunoglobulin A, and to study their expression and cross-reactivity with other fungal species. EXPERIMENTAL DESIGN: Twenty saliva from immunocompetent donors were used to detect and identify the immunoreactive proteins by 2D immunoblotting and LC-MS/MS...
October 2016: Proteomics. Clinical Applications
Natthanej Luplertlop, Potjaman Pumeesat, Watcharamat Muangkaew, Thanwa Wongsuk, Ana Alastruey-Izquierdo
The Scedosporium apiospermum species complex, comprising filamentous fungal species S. apiospermum sensu stricto, S. boydii, S. aurantiacum, S. dehoogii and S. minutispora, are important pathogens that cause a wide variety of infections. Although some species (S. boydii and S. apiospermum) have been isolated from patients in Thailand, no environmental surveys of these fungi have been performed in Thailand or surrounding countries. In this study, we isolated and identified species of these fungi from 68 soil and 16 water samples randomly collected from 10 parks in Bangkok...
2016: PloS One
Eduardo Alvarez, Camila Sanhueza
BACKGROUND: Scedosporium species are considered emerging agents causing illness in immunocompromised patients. In Chile, only Scedosporium apiospermum, Scedosporium boydii and Lomentospora prolificans haven been reported previously. AIMS: The study aimed to characterize genetically Scedosporium dehoogii strains from Chilean soil samples, and assessed the antifungal susceptibility profile to classic and novel putative antifungal molecules. METHODS: In 2014, several samples were obtained during a survey of soil fungi in urban areas from Chile...
July 23, 2016: Revista Iberoamericana de Micología
Diem K Bui, Petros E Carvounis
PURPOSE: To evaluate the visual outcomes following aggressive management of filamentous fungal endophthalmitis with prompt surgical intervention and oral and intravitreal voriconazole. METHODS: Retrospective chart review study of consecutive patients with culture- or biopsy-proven filamentous fungal endophthalmitis treated at an academic referral center. Clinical characteristics, treatment regimens, and visual outcomes were analyzed. RESULTS: Included were 5 patients, 1 with endogenous endophthalmitis due to systemic fusariosis and 4 due to exogenous endophthalmitis (1 with Fusarium, 2 with Scedosporium apiospermum, and 1 with Glomerella spp...
July 22, 2016: Journal of Ocular Pharmacology and Therapeutics
Thaís Pereira de Mello, Ana Carolina Aor, Simone Santiago Carvalho de Oliveira, Marta Helena Branquinha, André Luis Souza Dos Santos
In the present study, we have investigated some growth conditions capable of inducing the conidial germination in Scedosporium apiospermum, S. aurantiacum, S. minutisporum and Lomentospora prolificans. Germination in Sabouraud medium (pH 7.0, 37ºC, 5% CO2) showed to be a typically time-dependent event, reaching ~75% in S. minutisporum and > 90% in S. apiospermum, S. aurantiacum and L. prolificans after 4 h. Similar germination rate was observed when conidia were incubated under different media and pHs. Contrarily, temperature and CO2 tension modulated the germination...
June 27, 2016: Memórias do Instituto Oswaldo Cruz
Thaís P Mello, Ana Carolina Aor, Diego S Gonçalves, Sergio H Seabra, Marta H Branquinha, André L S Santos
Reported herein is the ability of Scedosporium apiospermum, S. aurantiacum, S. minutisporum and Lomentospora prolificans conidia to adhere, differentiate into hyphae and form biofilms on both polystyrene and lung epithelial cells. To different degrees, all of the fungi adhered to polystyrene after 4 h, with a predominance of those with germinated conidia. Prolonged fungi-polystyrene contact resulted in the formation of a monolayer of intertwined mycelia, which was identified as a typical biofilm structure due to the presence of a viable mycelial biomass, extracellular matrix and enhanced antifungal resistance...
August 2016: Biofouling
Barbara Garczewska, Sylwia Jarzynka, Jan Kuś, Wojciech Skorupa, Ewa Augustynowicz-Kopeć
INTRODUCTION: Cystic fibrosis (CF) is the most common monogenetic autosomal recessive disease in the human population. This systemic disease is characterized by changes in multiple organs, mainly in the lung tissue and digestive tract. More than 59% of CF patients become sensitized to fungal spores, mostly Aspergillus fumigatus. 5-15% of CF patients develop allergic bronchopulmonary aspergillosis. The aim of the study was to analyse the occurrence of yeast and filamentous fungi of the respiratory infections in CF patients and evaluation of drug resistance...
2016: Pneumonologia i Alergologia Polska
Bárbara Balandin, Miriam Aguilar, Isabel Sánchez, Araceli Monzón, Isabel Rivera, Clara Salas, Miguel Valdivia, Sara Alcántara, Aris Pérez, Piedad Ussetti
Infections due Scedosporium spp. in lung transplant recipients are associated with disseminated disease with high mortality rates. The adjunctive local antifungal therapy may be a useful option when systemic treatment is insufficient and/or surgery is not feasible. We present a case of mixed disseminated infection due Scedosporium apiospermum and S. prolificans in a lung transplant recipient. Combined local and systemic antifungal therapy provided an unusual long-term survival in the intensive care unit.
March 2016: Medical Mycology Case Reports
Chloe Goldman, Matthew J Akiyama, Julian Torres, Eddie Louie, Shane A Meehan
Scedosporium apiospermum, a ubiquitous environmental mold, is increasingly reported as causing invasive fungal disease in immunocompromised hosts. It poses a therapeutic challenge due to its intrinsic resistance to traditional antifungals and ability to recur despite demonstrating susceptibility. We present an immunocompromised patient with a cutaneous S. apiospermum infection that disseminated despite treatment with voriconazole, the drug of choice. Adding echinocandins and GM-CSF provided partial recovery, indicating a potential synergistic role of dual-antifungal and immunotherapeutic agents...
March 2016: Medical Mycology Case Reports
Päivi Jalava-Karvinen, Mikko Nyman, Maria Gardberg, Inka Harju, Ulla Hohenthal, Jarmo Oksi
We report a case of Scedosporium apiospermum mold causing ear infection, central skull base osteomyelitis and finally, occlusion of carotid artery in a 48-year-old diabetic man. The exact diagnosis was established and the severity of the disease understood several months after the onset of symptoms. Despite of appropriate antifungal therapy, and repeated surgical and otological procedures, the infection progressed to fatal cerebral infarction.
March 2016: Medical Mycology Case Reports
Ciara O'Connor, Fidelma Fitzpatrick, Seamus Looby, Karina O'Connell
BACKGROUND: The aim of this submission is to demonstrate the need for broad antimicrobial therapy, including empiric anti-fungal therapy, if rim-enhancing lesions are noted on cerebral imaging. METHODS: A retrospective microbiological and radiologic review of the management of a rare case of multiple Scedosporium apiospermum and vancomycin-resistant Enterococcus faecium intra-cranial abscesses in an immunocompromised patient was performed. A manual chart review assessing clinical and epidemiologic characteristics was completed including procedures and operative notes, use of invasive devices, biochemical and haematological blood test results, antimicrobial agents received, and documentation of a travel history...
August 2016: Surgical Infections
Angel Fernandez-Flores, Ramiro Lopez-Medrano, Carlos Fuster-Foz
Cutaneous fungal infections can result in disastrous episodes if improperly diagnosed and treated, especially in immunosuppressed patients. Although dermatopathologists are highly familiar with some filamentous fungi - such as Aspergillus and Zygomycetes - they are not so aware of other less common species. We report a case of ocular infection by Scedosporium apiospermum that started as conjunctivitis and resulted in Phthisis bulbi and subsequent exeresis of the left eye. We describe some of the main morphological features of the fungus as well as the important morphological clues for the differential diagnosis with some similar species, such as Aspergillus, Scopulariopsis, Fusarium, Paecilomyces and Zygomycetes...
May 2016: Journal of Cutaneous Pathology
Rita Padoan, Piercarlo Poli, Domenico Colombrita, Elisa Borghi, Silviana Timpano, Marco Berlucchi
Fungi are known pathogens in cystic fibrosis patients. A boy with cystic fibrosis boy presented with acute respiratory distress. Bronchoscopy showed airways obstruction by mucus plugs and bronchial casts. Scedosporium apiospermum was identified as the only pathogen. Bronchoalveolar lavage successfully resolved the acute obstruction. Plastic bronchitis is a new clinical picture of acute Scedosporium endobronchial colonization in cystic fibrosis patients.
June 2016: Pediatric Infectious Disease Journal
Pablo Zoroquiain, Sarah Alghamdi, Bryan Arthurs, Leonard Levin, Donald C Sheppard, Benjamin Ralph, Julia Burnier, Miguel N Burnier
A 56-year-old Asian woman presented with an upper eyelid mass. The lesion was exposed after eversion of the eyelid revealing a thickened tarsus with yellowish areas. Working diagnosis was sebaceous carcinoma. Biopsy was performed. Histopathological studies showed a mycotic eumycetoma with Splendore-Hoeppli phenomena and - microbiologic cultures grew Scedosporium apiospermum. The patient was started on voriconazole 200 mg po bid with adequate serum levels. A complete response was observed after 18 weeks of voriconazole therapy...
February 12, 2016: Ophthalmic Plastic and Reconstructive Surgery
Virginia Vanzzini-Zago, Sonia Corredor-Casas, Abelardo Rodríguez-Reyes, Francisca Hernández-Hernández, Patricia Manzano-Gayosso, Rubén López Martínez, Alan Ricardo Alba Orozco
BACKGROUND: Mycotic ocular infections caused by the Scedosporium apiospermum species complex are challenging to treat because of the delayed diagnoses and poor responses to antifungal drugs and surgical treatment. CASE REPORT: A case of a 69-year-old male patient with a history of diabetes mellitus type 2 and prior surgery on the right femur is described. In the 10 days prior to the ophthalmic consultation he started with ocular pain, adding to a previous and progressive loss of visual acuity in his right eye...
April 2016: Revista Iberoamericana de Micología
Renata O R Calixto, Rodrigo Rollin-Pinheiro, Mariana I D da Silva, Livia C Liporagi-Lopes, Jardel M Vieira, Guilherme L Sassaki, Eliana Barreto-Bergter
Glucosylceramides (GlcCer) are the main neutral glycosphingolipids expressed in fungal cells. In this work, glucosylceramides (GlcCer) were extracted from three strains of Scedosporium (Pseudallescheria) boydii, one strain of Pseudallescheria ellipsoidea and one strain of Pseudallescheria angusta and purified by several chromatographic steps. Using high-performance thin layer chromatography (HPTLC), we found a similarity between GlcCer obtained from all of the analysed strains. A detailed structural analysis of the P...
February 2016: Fungal Biology
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