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Olga C Rojas, Rafael B R León-Cachón, Maria Moreno-Treviño, Gloria M González
Mycetoma is a chronic granulomatous, subcutaneous disease endemic in tropical and subtropical countries. It is currently a health problem in rural areas of Africa, Asia and South America. Nine cases of mycetoma were analysed in a retrospective study. All isolates were identified by morphological features. The level of species identification was reached by molecular tools. Definitive identification of fungi was performed using sequence analysis of the ITS of the ribosomal DNA region and the ribosomal large-subunit D1/D2...
October 21, 2016: Mycoses
Nancy Awad Mohamed, Ahmed Hassan Fahal
No abstract text is available yet for this article.
October 2016: PLoS Neglected Tropical Diseases
Sankar Neelakantan, Arul Arokia Sensan Babu, Rakesh Anandarajan
No abstract text is available yet for this article.
October 4, 2016: BMJ Case Reports
Talha Khan Burki
No abstract text is available yet for this article.
September 2016: Lancet Infectious Diseases
Angoori Gnaneshwar Rao
No abstract text is available yet for this article.
July 2016: Indian Dermatology Online Journal
El Samani Wadaa Mohamed, Nancy Seif El Din, Ahmed Hassan Fahal
No abstract text is available yet for this article.
July 2016: PLoS Neglected Tropical Diseases
Jamie L Wagner, Allison M Bell
Amphotericin B deoxycholate (AmBd) is rarely used due to its adverse effect profile, which includes nephrotoxicity, infusion-related reactions, and hepatotoxicity. The incidence of hepatotoxicity related to AmBd is 18-23%, but the reports of this adverse effect are mainly in immunocompromised patients receiving chemotherapy. We report a case of AmBd-related acute hepatic injury in an immunocompetent male with multiple medical problems. The patient initially had acute hepatic injury likely caused by poor nutritional status and a diagnosis of failure to thrive, but was recovering...
April 2016: Journal of Pharmacology & Pharmacotherapeutics
Ahmed H Fahal, Malcolm A Finkelman, Yonglong Zhang, Wendy W J van de Sande
Mycetoma can be caused by bacteria (actinomycetoma) or fungi (eumycetoma). Here, we demonstrated in 45 eumycetoma patients, 30 actinomycetoma patients, and 30 healthy controls that (1→3)-β-d-glucan detection in serum cannot reliably be used to discriminate between the two types of mycetoma.
October 2016: Journal of Clinical Microbiology
Amre Nasr, Amir Abushouk, Anhar Hamza, Emmanuel Siddig, Ahmed H Fahal
Eumycetoma is a progressive and destructive chronic granulomatous subcutaneous inflammatory disease caused by certain fungi, the most common being Madurella mycetomatis. The host defence mechanisms against fungi usually range from an early non-specific immune response to activation and induction of specific adaptive immune responses by the production of Th-1 and Th-2 cytokines. The aim of this study is to determine the levels of Th-1 and Th-2 cytokines in patients infected with Madurella mycetomatis, and the association between their levels and disease prognosis...
July 2016: PLoS Neglected Tropical Diseases
Aradhana Masih, Pradeep K Singh, Shallu Kathuria, Kshitij Agarwal, Jacques F Meis, Anuradha Chowdhary
Aspergillus species cause a wide spectrum of clinical infections. Although Aspergillus fumigatus and Aspergillus flavus remain the most commonly isolated species in aspergillosis, in the last decade, rare and cryptic Aspergillus species have emerged in diverse clinical settings. The present study analyzed the distribution and in vitro antifungal susceptibility profiles of rare Aspergillus species in clinical samples from patients with suspected aspergillosis in 8 medical centers in India. Further, a matrix-assisted laser desorption ionization-time of flight mass spectrometry in-house database was developed to identify these clinically relevant Aspergillus species...
September 2016: Journal of Clinical Microbiology
Jose Gavito-Higuera, Carola Birgit Mullins, Luis Ramos-Duran, Hugo Sandoval, Nassim Akle, Ramon Figueroa
Fungal infections of the nose and paranasal sinuses can be categorized into invasive and non-invasive forms. The clinical presentation and course of the disease is primarily determined by the immune status of the host and can range from harmless or subtle presentations to life threatening complications. Invasive fungal infections are categorized into acute, chronic or chronic granulomatous entities. Immunocompromised patients with poorly controlled diabetes mellitus, HIV and patients receiving chemotherapy or chronic oral corticosteroids are mostly affected...
2016: Journal of Clinical Imaging Science
J E Carrasco-Zuber, C Navarrete-Dechent, A Bonifaz, F Fich, V Vial-Letelier, D Berroeta-Mauriziano
The deep mycoses are uncommon in our setting. These fungal infections occur mainly in immunosuppressed patients or in tropical climates, and include subcutaneous infections and systemic infections. The skin is always involved in the former. In the first part of this review, we describe the main subcutaneous mycoses: sporotrichosis, chromoblastomycosis, mycetoma, phaeohyphomycosis, hyalohyphomycosis, and lacaziosis. Early recognition and treatment is important, as these infections are frequently associated with high morbidity...
June 30, 2016: Actas Dermo-sifiliográficas
Carolina Gonzalez-Carrillo, Cassandra Millan-Sauceda, Hector Gerardo Lozano-Garza, Rocio Ortiz-Lopez, Ramiro Elizondo-Gonzalez, Oliverio Welsh, Jorge Ocampo-Candiani, Lucio Vera-Cabrera
Nocardia species, particularly Nocardia brasiliensis, are etiologic agents of mycetoma, a chronic subcutaneous infection. Until now, little has been known about the pathogenic mechanisms involved in nocardial infection. Traditionally, subculture in rich media has been a simple way to induce attenuation. In this work, we report the changes in virulence toward mice and in genomic constitution of N. brasiliensis produced after 200 continuous subcultures in brain heart infusion (BHI) medium (P-200 strain). The ability of the N...
September 2016: Infection and Immunity
Suleiman Hussein Suleiman, El Sammani Wadaella, Ahmed Hassan Fahal
Surgical intervention is an integral component in the diagnosis and management of mycetoma. Surgical treatment is indicated for small, localised lesions and massive lesions to reduce the mycetoma load and to enable better response to medical therapy. It is also a life-saving procedure in patients with massive disease and sepsis. Surgical options for mycetoma treatment range from a wide local surgical excision to repetitive debridement excisions to amputation of the affected part. Adequate anaesthesia, a bloodless field, wide local excision with adequate safety margins in a suitable surgical facility, and expert surgeons are mandatory to achieve the best surgical outcome...
June 2016: PLoS Neglected Tropical Diseases
M Develoux
Mycetoma are chronic subcutaneous infections, endemic in dry tropical regions. It can be caused either by actinomycetes or by fungi, presenting as filamentous grains in vivo. The foot is the most common localization. The main complication is osseous involvement. Patients are rural workers living in areas situated far from medical centers. Too often, they reach well-equipped hospitals with advanced mutilating lesions. Early case detection is the first condition for good therapeutic results. Clinical presentations of actinomycetoma and eumycetoma are similar, only biological diagnosis can distinguish the two etiological forms...
June 2016: Journal de Mycologie Médicale
B Dupont, A Datry, S Poirée, A Canestri, S Boucheneb, E Fourniols
UNLABELLED: We report the case of a fungal mycetoma due to Madurella mycetomatis that failed to respond to surgery and antifungal treatment but responded strongly to the addition of a non-steroidal anti-inflammatory drug (NSAID). This African patient was born in Mauritania in 1972. He was a herdsman, living close to the Senegal River. The first nodules appeared on the left foot at the age of 13years (1985). The patient suffered frequent flare-ups with the appearance of black grains and underwent surgery in 1988 and 1992 in Senegal...
June 2016: Journal de Mycologie Médicale
Sandra Smit, Martijn F L Derks, Sander Bervoets, Ahmed Fahal, Willem van Leeuwen, Alex van Belkum, Wendy W J van de Sande
We present the first genome sequence for a strain of the main mycetoma causative agent, Madurella mycetomatis This 36.7-Mb genome sequence will offer new insights into the pathogenesis of mycetoma, and it will contribute to the development of better therapies for this neglected tropical disease.
2016: Genome Announcements
Andrew M Borman, Marie Desnos-Ollivier, Colin K Campbell, Paul D Bridge, Eric Dannaoui, Elizabeth M Johnson
Eumycetoma is a debilitating, chronic, fungal infection that is endemic in India, Indonesia, and parts of Africa and South and Central America. It remains a neglected tropical disease in need of international recognition. Infections follow traumatic implantation of saprophytic fungi and frequently require radical surgery or amputation in the absence of appropriate treatment. Several fungal species can cause black-grain mycetomas, including Madurella spp. (Sordariales), Falciformispora spp., Trematosphaeria grisea, Biatriospora mackinnonii, Pseudochaetosphaeronema larense, and Medicopsis romeroi (all Pleosporales)...
July 2016: Journal of Clinical Microbiology
Courtney Y Kauh, Lindell R Gentry, Gregory K Hartig, Mark J Lucarelli
Tearing is a frequently encountered chief complaint in an ophthalmologist's office. Certain associated atypical symptoms may warrant further workup. The authors present a case of a patient presenting with painful tearing which elicited further evaluation with CT imaging. This revealed a maxillary sinus fungus ball as the cause for the patient's tearing.
April 4, 2016: Ophthalmic Plastic and Reconstructive Surgery
Richard Antrobus, Gabriel Wong, Julie Jones, Aarnoud Huissoon
Patients with chronic granulomatous disease are predisposed to fungal infections and are therefore routinely prescribed antifungal prophylaxis. We report a case where acremonium was responsible for causing a cutaneous infection (mycetoma) despite antifungal prophylaxis. Treatment with voriconazole was initiated and the infection gradually resolved. This case highlights the need for careful clinical follow-up and thorough investigation of patients who have a neutrophil immunodeficiency.
2016: Case Reports in Immunology
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