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Mycetoma

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https://www.readbyqxmd.com/read/29746460/a-holistic-approach-to-the-mycetoma-management
#1
Sahar Mubarak Bakhiet, Ahmed Hassan Fahal, Ahmed Mudawi Musa, El Samani Wadaa Mohamed, Rowa Fathelrahman Omer, Eiman Siddig Ahmed, Mustafa El Nour, El Rayah Mohamed Mustafa, Manar El Sheikh A Rahman, Suliman Hussein Suliman, Mohamed A Gadir El Mamoun, Hajo Mohamed El Amin
Mycetoma, one of the badly neglected tropical diseases, it is a localised chronic granulomatous inflammatory disease characterised by painless subcutaneous mass and formation of multiple sinuses that produce purulent discharge and grains. If untreated early and appropriately, it usually spread to affect the deep structures and bone resulting in massive damage, deformities and disabilities. It can also spread via the lymphatics and blood leading to distant secondary satellites associated with high morbidity and mortality...
May 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29719823/mycetomas-the-experience-of-the-dermatology-unit-of-the-university-of-milan
#2
Gianluca Nazzaro, Stefano Veraldi
No abstract text is available yet for this article.
January 2018: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/29707667/identification-of-fungal-causative-agents-of-rhinosinusitis-from-mashhad-iran
#3
Mohammad J Najafzadeh, Karim Jalaeian Samani, Jos Houbraken, Majid Alizadeh, Abdolmajid Fata, Ali Naseri, Hossein Zarrinfar, Mehdi Bakhshaee
Background and Purpose: Rhinosinusitis is a common disorder, influencing approximately 20% of the population at some time of their lives. It was recognized and reported with expanding recurrence over the past two decades worldwide. Undoubtedly, correct diagnosis of fungi in patients with fungal rhinosinusitis affects the treatment planning and prognosis of the patients. Identification of the causative agents using the standard mycological procedures remains difficult and time-consuming...
September 2017: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/29698504/addressing-the-most-neglected-diseases-through-an-open-research-model-the-discovery-of-fenarimols-as-novel-drug-candidates-for-eumycetoma
#4
Wilson Lim, Youri Melse, Mickey Konings, Hung Phat Duong, Kimberly Eadie, Benoît Laleu, Ben Perry, Matthew H Todd, Jean-Robert Ioset, Wendy W J van de Sande
Eumycetoma is a chronic infectious disease characterized by a large subcutaneous mass, often caused by the fungus Madurella mycetomatis. A combination of surgery and prolonged medication is needed to treat this infection with a success rate of only 30%. There is, therefore, an urgent need to find more effective drugs for the treatment of this disease. In this study, we screened 800 diverse drug-like molecules and identified 215 molecules that were active in vitro. Minimal inhibitory concentrations were determined for the 13 most active compounds...
April 26, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29557534/mycetoma-in-the-togolese-an-update-from-a-single-center-experience
#5
Tchin Darré, Bayaki Saka, Abas Mouhari-Toure, Mazamaesso Tchaou, Améyo Monique Dorkenoo, Kwamé Doh, Atchi Walla, Koffi Amégbor, Vincent Palokinam Pitché, Gado Napo-Koura
BACKGROUND: Mycetoma is a chronic inflammatory process caused either by fungi (eumycetoma) or bacteria (actinomycetoma). In this retrospective study, we report epidemiologic and histopathological data of mycetoma observed in the Lome Hospital, Togo in a 25-year period (1992-2016). METHODOLOGY: This is a retrospective study, over a period of 25 years, to analyze epidemiological and etiological findings of mycetomas seen in the single laboratory of pathological anatomy of the Lomé, Togo...
March 20, 2018: Mycopathologia
https://www.readbyqxmd.com/read/29556401/role-of-tsukamurella-species-in-human-infections-first-literature-review
#6
REVIEW
S Safaei, M Fatahi-Bafghi, Omid Pouresmaeil
Tsukamurella is an aerobic, Gram-positive and nonmotile bacterium. It was first isolated in 1941 from the mycetoma and ovaries of the bedbug. The primary strains were named Corynebacterium paurometabolum and Gordona aurantiaca and are different from the Collins et al. , 1988 classification of the new Tsukamurella genus. Human infections with Tsukamurella species are rare because the species is a kind of saprophyte bacterium; however, most information regarding this species comes from case reports. Molecular markers for the identification Tsukamurella include sequencing of 16S rRNA, groEL, rpoB, secA1 and ssrA genes...
March 2018: New Microbes and New Infections
https://www.readbyqxmd.com/read/29261466/case-249-intramuscular-mycetoma
#7
Zafar Neyaz, Namita Mohindra, Ankur Bhatnagar, Rungmei S K Marak
History A 21-year-old man presented with swelling of the medial aspect of the left thigh of 1-month duration. There was no history of fever or penetrating injury in the left thigh. The patient had undergone renal transplantation 7 years earlier and had been taking immunosuppressants since transplantation. He had undergone two surgeries at the same site in the medial aspect of the left thigh in the past 3 years for a similar problem. At physical examination, there was swelling in the medial aspect of the left thigh, with mild tenderness...
January 2018: Radiology
https://www.readbyqxmd.com/read/29151624/biodiversity-and-human-pathogenicity-of-phialophora-verrucosa-and-relatives-in-chaetothyriales
#8
Y Li, J Xiao, G S de Hoog, X Wang, Z Wan, J Yu, W Liu, R Li
Phialophora as defined by its type species P. verrucosa is a genus of Chaetothyriales , and a member of the group known as 'black yeasts and relatives'. Phialophora verrucosa has been reported from mutilating human infections such as chromoblastomycosis, disseminated phaeohyphomycosis and mycetoma, while morphologically similar fungi are rather commonly isolated from the environment. Phenotypes are insufficient for correct species identification, and molecular data have revealed significant genetic variation within the complex of species currently identified as P...
June 2017: Persoonia
https://www.readbyqxmd.com/read/29143119/infectious-and-non-infectious-diseases-causing-the-air-crescent-sign-a-state-of-the-art-review
#9
REVIEW
Joyce Betta Sevilha, Rosana Souza Rodrigues, Miriam Menna Barreto, Gláucia Zanetti, Bruno Hochhegger, Edson Marchiori
Aspergilloma, also known as mycetoma or fungus ball, is characterized by a round or oval mass with soft-tissue attenuation within a preexisting lung cavity. The typical computed tomography (CT) aspect of an aspergilloma is a mass separated from the wall of the cavity by an airspace of variable size and shape, resulting in the air crescent sign, also known as the meniscus sign. This CT feature is non-specific and can be simulated by several other entities that result in intracavitary masses. This review describes the main clinical and imaging aspects of the infectious and non-infectious diseases that may present with fungus-ball appearance, including pulmonary hydatid cyst, Rasmussen aneurysm, pulmonary gangrene, intracavitary clot, textiloma, lung cancer, metastasis, and teratoma, focusing on the differential diagnosis...
February 2018: Lung
https://www.readbyqxmd.com/read/29102309/challenges-in-culture-negative-cases-of-madurella-mycetomatis-a-case-report-re-accentuating-pcr-as-an-essential-diagnostic-tool
#10
S K, S Das, D Pandhi, G Rai, M A Ansari, C Gupta, S Haque, S A Dar
Identification of dematiaceous fungi responsible for black-grain mycetoma has remained cumbersome and time consuming for years leading to delayed diagnosis and thereby increased agony to patients. Moreover, difficult morphology of some of these fungi demanding enough expertise for species identification in addition to culture-negativity has often led to misdiagnosis and hence inapt treatment to the patients. We report the identification of Madurella mycetomatis from culture-negative black granules discharged from foot nodular lesions of a 27 years old male using PCR followed by sequencing of the internal transcribed spacer region...
December 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28992315/amphotericin-b-and-terbinafine-but-not-the-azoles-prolong-survival-in-galleria-mellonella-larvae-infected-with-madurella-mycetomatis
#11
Wendy Kloezen, Florianne Parel, Roger Brüggemann, Khalid Asouit, Marilyn Helvert-van Poppel, Ahmed Fahal, Johan Mouton, Wendy van de Sande
Mycetoma is a tropical neglected disease characterized by large subcutaneous lesions in which the causative organisms reside in the form of grains. The most common causative agent is Madurella mycetomatis. Antifungal therapy often fails due to these grains, but to identify novel treatment options has been difficult since grains do not form in vitro. We recently used Galleria mellonella larvae to develop an in vivo grain model. In the current study, we set out to determine the therapeutic efficacy of commonly used antifungal agents in this larval model...
September 14, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28992217/closing-the-mycetoma-knowledge-gap
#12
Wendy van de Sande, Ahmed Fahal, Sarah Abdalla Ahmed, Julian Alberto Serrano, Alexandro Bonifaz, Ed Zijlstra
On 28th May 2016, mycetoma was recognized as a neglected tropical disease by the World Health Organization. This was the result of a 4-year journey starting in February 2013 with a meeting of global mycetoma experts. Knowledge gaps were identified and included the incidence, prevalence, and mapping of mycetoma; the mode of transmission; the development of methods for early diagnosis; and better treatment. In this review, we review the road to recognition, the ISHAM working group meeting in Argentina, and we address the progress made in closing the knowledge gaps since 2013...
September 9, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28940391/cervical-and-middle-dorsal-actinomycetomas-from-guerrero-state-mexico
#13
Guadalupe E Estrada-Chávez, Roberto Estrada, Ramon Fernandez, Roberto Arenas, Alain Reyes, Cindy Guevara, Guadalupe Chávez-López
BACKGROUND: Mycetomas are frequent subcutaneous mycoses with typical clinical characteristics such as sinuses, blood-stained, serous, or purulent exudates as well as local swelling. Even though the most commonly affected areas are the lower limbs, we report four cases affecting the neck and midback regions, of which three were young females. We draw attention to the importance of early identification of these cases for prevention and specific treatment in order to avoid severe consequences or irreversible complications such as quadriplegia...
November 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28876622/actinomycosis-of-the-foot-a-south-african-case
#14
K E Polden, H Jehle
Mycetoma is a chronic infection, characterised by severe disability and discomfort to patients. This condition is common throughout tropical regions of the world. The Indian subcontinent and north-east Africa, especially Sudan, bear the majority of the disease burden. Due to the limited resources and isolation of these areas, the condition is usually misdiagnosed or incorrectly managed. The World Health Organisation listed the condition as a "neglected disease" in 2013. The creation of the Mycetoma Research Centre (MRC) by the University of Khartoum in 1991 has greatly contributed to the current understanding of this disabling condition...
June 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28837657/mycetoma-laboratory-diagnosis-review-article
#15
REVIEW
Amel Altayeb Ahmed, Wendy van de Sande, Ahmed Hassan Fahal
Mycetoma is a unique neglected tropical disease caused by a substantial number of microorganisms of fungal or bacterial origins. Identification of the causative organism and the disease extension are the first steps in the management of the affected patients and predicting disease treatment outcome and prognosis. Different laboratory-based diagnostic tools and techniques were developed over the years to determine and identify the causative agents. These include direct microscopy and cytological, histopathological, and immunohistochemical techniques in addition to the classical grain culture...
August 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28794542/mycetoma-an-update
#16
REVIEW
Vineet Relhan, Khushbu Mahajan, Pooja Agarwal, Vijay Kumar Garg
Mycetoma is a localized chronic, suppurative, and deforming granulomatous infection seen in tropical and subtropical areas. It is a disorder of subcutaneous tissue, skin and bones, mainly of feet, characterized by a triad of localized swelling, underlying sinus tracts, and production of grains or granules. Etiological classification divides it into eumycetoma caused by fungus, and actinomycetoma caused by bacteria. Since the treatment of these two etiologies is entirely different, a definite diagnosis after histopathological and microbiological examination is mandatory, though difficult...
July 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28793023/two-simultaneous-mycetomas-caused-by-fusarium-verticillioides-and-madurella-mycetomatis
#17
Alexandro Bonifaz, Mariana Saldaña, Javier Araiza, Patricia Mercadillo, Andrés Tirado-Sánchez
Mycetoma is a chronic granulomatous disease, classified into eumycetoma caused by fungi and actinomycetoma due to aerobic filamentous actinomycetes. Mycetoma can be found in geographic areas near the Tropic of Cancer. Mexico is one of the countries in which actinomycetoma is endemic. We report an extraordinary case of an adult male with double eumycetoma caused by Madurella mycetomatis and Fusarium verticillioides on both feet.
2017: Revista do Instituto de Medicina Tropical de São Paulo
https://www.readbyqxmd.com/read/28774696/neglected-endemic-mycoses
#18
REVIEW
Flavio Queiroz-Telles, Ahmed Hassan Fahal, Diego R Falci, Diego H Caceres, Tom Chiller, Alessandro C Pasqualotto
Fungi often infect mammalian hosts via the respiratory route, but traumatic transcutaneous implantation is also an important source of infections. Environmental exposure to spores of pathogenic fungi can result in subclinical and unrecognised syndromes, allergic manifestations, and even overt disease. After traumatic cutaneous inoculation, several fungi can cause neglected mycoses such as sporotrichosis, chromoblastomycosis, mycetoma, entomophthoramycosis, and lacaziosis. Most of these diseases have a subacute to chronic course and they can become recalcitrant to therapy and lead to physical disabilities, including inability to work, physical deformities, and amputations...
November 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28736852/successful-medical-treatment-of-an-aspergillus-terreus-mycetoma-of-the-nostril-lip-in-a-16-year-old-fjord-pony-gelding-with-pituitary-pars-intermedia-dysfunction
#19
Pia K Randleff-Rasmussen, Marion Mosca, Frédéric Knoerr, Didier Pin, Isabelle Desjardins
BACKGROUND: Mycetoma is a chronic, proliferative lesion of cutaneous/subcutaneous tissue characterized by draining tracts and granules in the discharge caused by actinomycetes (actinomycetoma) or filamentous fungi (eumycotic mycetoma). OBJECTIVES: This case report describes the unusual finding of a cutaneous mycetoma of the lateral wing of the right nostril in a gelding. ANIMAL: A 16-year-old Fjord gelding with suspected pituitary pars intermedia dysfunction (PPID) was presented for evaluation of a nonpainful, firm and raised mass involving the lateral wing of the right nostril and the lip...
July 23, 2017: Veterinary Dermatology
https://www.readbyqxmd.com/read/28719270/mycetoma-madura-foot-in-israel-recent-cases-and-a-systematic-review-of-the-literature
#20
REVIEW
Ohad Bitan, Yonit Wiener-Well, Rina Segal, Eli Schwartz
AbstractMycetoma is a chronic soft tissue infection caused by fungal or bacterial pathogens, and is endemic in tropical and subtropical regions. Cases in developed countries outside the mycetoma belt are rare and usually imported by immigrants. Sporadic cases have been reported in Israel. Unpublished cases in the participating medical centers are reported. In addition, a systematic review of the literature was performed. All published mycetoma cases diagnosed in Israel were included with relevant variables collected...
June 2017: American Journal of Tropical Medicine and Hygiene
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