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Mycetoma

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https://www.readbyqxmd.com/read/27904882/first-case-of-actinomycetoma-in-france-due-to-a-novel-nocardia-species-nocardia-boironii-sp-nov
#1
Jacques M Gilquin, Brigitte Riviere, Valme Jurado, Bernard Audouy, Jean-Baptiste Kouatche, Emmanuelle Bergeron, Delphine Mouniée, Thierry Molina, Philippe Faure, Cesáreo Saiz-Jimenez, Verónica Rodríguez-Nava
Bacterial mycetoma is a neglected disease mainly observed in tropical area countries and typically associated with rural conditions, making its presence in developed countries of temperate climate areas rare. However, we report the first case of an autochthonous mycetoma case in continental France that originated from a new Nocardia species. A Gram-positive filamentous bacterium (OFN 14.177(T)) was isolated from a pus sample from the mycetoma of a male French patient 92 years old suffering from chronic lymphocytic leukemia...
November 2016: MSphere
https://www.readbyqxmd.com/read/27904058/two-cases-of-chromomycosis-identified-by-molecular-phylogenetic-analysis
#2
Takayo Mitomo, Yukiko Ushigome, Tomoo Fukuda, Yoko Kano, Tetsuo Shiohara
Chromomycosis is an infection caused by dematiaceous fungi. These fungi belong to several genera with varied clinical presentations and parasitic forms. The disease is roughly classified into three types: chromoblastomycosis, black-grain mycetoma, and phaeohyphomycosis. While there are many kinds of dematiaceous fungi, the major etiologic agent is Fonsecaea pedrosoi, which to date has accounted for 90% of chromoblastomycosis cases. The genus Fonsecaea has recently been assessed via rRNA ITS sequence analysis, and species have been classified into F...
2016: Medical Mycology Journal
https://www.readbyqxmd.com/read/27853914/non-dermatophyte-dermatoses-mimicking-dermatophytoses-in-animals
#3
Didier Pin
Dermatophytoses in animals are fungal diseases of the skin caused by dermatophyte fungi of the genus Microsporum or Trichophyton. Because the infection is generally follicular, the most common clinical sign is one or many circular areas of alopecia with variable erythema, scaling and crusting, and the primary differential diagnoses are follicular infections, such as bacterial folliculitis and demodicosis. Although dermatophyte folliculitis or ringworm is the most commonly observed lesion of dermatophytoses in animals, other presentations may be observed according to the host species and the dermatophyte involved: dermatophyte folliculitis or ringworm, scaling and crusting in dermatophytosis due to Microsporum persicolor, nodule in case of kerion or mycetoma, matted hairs, seborrheic dermatosis or miliary dermatitis in cats, generalized exfoliative dermatoses in dogs, cats and horses, superficial non-follicular pustules, papules and macules in the Devon Rex cat, pruritic dermatophytoses in dogs, cats and horses, and onychomycosis in dogs, cats and horses...
November 16, 2016: Mycopathologia
https://www.readbyqxmd.com/read/27798643/predictors-of-post-operative-mycetoma-recurrence-using-machine-learning-algorithms-the-mycetoma-research-center-experience
#4
Ali Wadal, Tusneem Ahmed Elhassan, Hajer Ahmed Zein, Manar Elsheikh Abdel-Rahman, Ahmed Hassan Fahal
Post-operative recurrence in mycetoma after adequate medical and surgical treatment is common and a serious problem. It has health, socio-economic and psychological detrimental effects on patients and families. It is with this in mind, we set out to determine the predictors of post-operative recurrence in mycetoma. The study included 1013 patients with Madurella mycetomatis causing eumycetoma who underwent surgical excision at the Mycetoma Research Centre, Khartoum, Sudan in the period 1991-2015. The clinical records of these patients were reviewed and relevant information was collected using a pre-designed data collection sheet...
October 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27766680/molecular-identification-of-unusual-mycetoma-agents-isolated-from-patients-in-venezuela
#5
Olga C Rojas, Rafael B R León-Cachón, Maria Moreno-Treviño, Gloria M González
Mycetoma is a chronic granulomatous, subcutaneous disease endemic in tropical and subtropical countries. It is currently a health problem in rural areas of Africa, Asia and South America. Nine cases of mycetoma were analysed in a retrospective study. All isolates were identified by morphological features. The level of species identification was reached by molecular tools. Definitive identification of fungi was performed using sequence analysis of the ITS of the ribosomal DNA region and the ribosomal large-subunit D1/D2...
October 21, 2016: Mycoses
https://www.readbyqxmd.com/read/27711109/mycetoma-pulmonary-secondaries-from-a-gluteal-eumycetoma-an-unusual-presentation
#6
Nancy Awad Mohamed, Ahmed Hassan Fahal
No abstract text is available yet for this article.
October 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27702932/-dot-in-circle-sign-a-characteristic-finding-in-ultrasound-and-mr-imaging-of-soft-tissue-mycetomas
#7
Sankar Neelakantan, Arul Arokia Sensan Babu, Rakesh Anandarajan
No abstract text is available yet for this article.
October 4, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27684346/starting-from-scratch-the-unique-neglect-of-mycetoma
#8
Talha Khan Burki
No abstract text is available yet for this article.
September 2016: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/27559532/mycetoma
#9
Angoori Gnaneshwar Rao
No abstract text is available yet for this article.
July 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27442512/multiple-mycetoma-lung-secondaries-from-knee-eumycetoma-an-unusual-complication
#10
El Samani Wadaa Mohamed, Nancy Seif El Din, Ahmed Hassan Fahal
No abstract text is available yet for this article.
July 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27440960/acute-hepatic-injury-with-amphotericin-b-deoxycholate-in-an-immunocompetent-patient
#11
Jamie L Wagner, Allison M Bell
Amphotericin B deoxycholate (AmBd) is rarely used due to its adverse effect profile, which includes nephrotoxicity, infusion-related reactions, and hepatotoxicity. The incidence of hepatotoxicity related to AmBd is 18-23%, but the reports of this adverse effect are mainly in immunocompromised patients receiving chemotherapy. We report a case of AmBd-related acute hepatic injury in an immunocompetent male with multiple medical problems. The patient initially had acute hepatic injury likely caused by poor nutritional status and a diagnosis of failure to thrive, but was recovering...
April 2016: Journal of Pharmacology & Pharmacotherapeutics
https://www.readbyqxmd.com/read/27440815/detection-of-1%C3%A2-3-%C3%AE-d-glucan-in-eumycetoma-patients
#12
Ahmed H Fahal, Malcolm A Finkelman, Yonglong Zhang, Wendy W J van de Sande
Mycetoma can be caused by bacteria (actinomycetoma) or fungi (eumycetoma). Here, we demonstrated in 45 eumycetoma patients, 30 actinomycetoma patients, and 30 healthy controls that (1→3)-β-d-glucan detection in serum cannot reliably be used to discriminate between the two types of mycetoma.
October 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27434108/th-1-th-2-cytokines-profile-among-madurella-mycetomatis-eumycetoma-patients
#13
Amre Nasr, Amir Abushouk, Anhar Hamza, Emmanuel Siddig, Ahmed H Fahal
Eumycetoma is a progressive and destructive chronic granulomatous subcutaneous inflammatory disease caused by certain fungi, the most common being Madurella mycetomatis. The host defence mechanisms against fungi usually range from an early non-specific immune response to activation and induction of specific adaptive immune responses by the production of Th-1 and Th-2 cytokines. The aim of this study is to determine the levels of Th-1 and Th-2 cytokines in patients infected with Madurella mycetomatis, and the association between their levels and disease prognosis...
July 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27413188/identification-by-molecular-methods-and-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry-and-antifungal-susceptibility-profiles-of-clinically-significant-rare-aspergillus-species-in-a-referral-chest-hospital-in-delhi-india
#14
Aradhana Masih, Pradeep K Singh, Shallu Kathuria, Kshitij Agarwal, Jacques F Meis, Anuradha Chowdhary
Aspergillus species cause a wide spectrum of clinical infections. Although Aspergillus fumigatus and Aspergillus flavus remain the most commonly isolated species in aspergillosis, in the last decade, rare and cryptic Aspergillus species have emerged in diverse clinical settings. The present study analyzed the distribution and in vitro antifungal susceptibility profiles of rare Aspergillus species in clinical samples from patients with suspected aspergillosis in 8 medical centers in India. Further, a matrix-assisted laser desorption ionization-time of flight mass spectrometry in-house database was developed to identify these clinically relevant Aspergillus species...
September 2016: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/27403401/sinonasal-fungal-infections-and-complications-a-pictorial-review
#15
Jose Gavito-Higuera, Carola Birgit Mullins, Luis Ramos-Duran, Hugo Sandoval, Nassim Akle, Ramon Figueroa
Fungal infections of the nose and paranasal sinuses can be categorized into invasive and non-invasive forms. The clinical presentation and course of the disease is primarily determined by the immune status of the host and can range from harmless or subtle presentations to life threatening complications. Invasive fungal infections are categorized into acute, chronic or chronic granulomatous entities. Immunocompromised patients with poorly controlled diabetes mellitus, HIV and patients receiving chemotherapy or chronic oral corticosteroids are mostly affected...
2016: Journal of Clinical Imaging Science
https://www.readbyqxmd.com/read/27374381/cutaneous-involvement-in-the-deep-mycoses-a-literature-review-part-i-subcutaneous-mycoses
#16
J E Carrasco-Zuber, C Navarrete-Dechent, A Bonifaz, F Fich, V Vial-Letelier, D Berroeta-Mauriziano
The deep mycoses are uncommon in our setting. These fungal infections occur mainly in immunosuppressed patients or in tropical climates, and include subcutaneous infections and systemic infections. The skin is always involved in the former. In the first part of this review, we describe the main subcutaneous mycoses: sporotrichosis, chromoblastomycosis, mycetoma, phaeohyphomycosis, hyalohyphomycosis, and lacaziosis. Early recognition and treatment is important, as these infections are frequently associated with high morbidity...
June 30, 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/27354446/genomic-changes-associated-with-the-loss-of-nocardia-brasiliensis-virulence-in-mice-after-200-in-vitro-passages
#17
Carolina Gonzalez-Carrillo, Cassandra Millan-Sauceda, Hector Gerardo Lozano-Garza, Rocio Ortiz-Lopez, Ramiro Elizondo-Gonzalez, Oliverio Welsh, Jorge Ocampo-Candiani, Lucio Vera-Cabrera
Nocardia species, particularly Nocardia brasiliensis, are etiologic agents of mycetoma, a chronic subcutaneous infection. Until now, little has been known about the pathogenic mechanisms involved in nocardial infection. Traditionally, subculture in rich media has been a simple way to induce attenuation. In this work, we report the changes in virulence toward mice and in genomic constitution of N. brasiliensis produced after 200 continuous subcultures in brain heart infusion (BHI) medium (P-200 strain). The ability of the N...
September 2016: Infection and Immunity
https://www.readbyqxmd.com/read/27336736/the-surgical-treatment-of-mycetoma
#18
REVIEW
Suleiman Hussein Suleiman, El Sammani Wadaella, Ahmed Hassan Fahal
Surgical intervention is an integral component in the diagnosis and management of mycetoma. Surgical treatment is indicated for small, localised lesions and massive lesions to reduce the mycetoma load and to enable better response to medical therapy. It is also a life-saving procedure in patients with massive disease and sepsis. Surgical options for mycetoma treatment range from a wide local surgical excision to repetitive debridement excisions to amputation of the affected part. Adequate anaesthesia, a bloodless field, wide local excision with adequate safety margins in a suitable surgical facility, and expert surgeons are mandatory to achieve the best surgical outcome...
June 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27260344/-mycetoma-and-their-treatment
#19
REVIEW
M Develoux
Mycetoma are chronic subcutaneous infections, endemic in dry tropical regions. It can be caused either by actinomycetes or by fungi, presenting as filamentous grains in vivo. The foot is the most common localization. The main complication is osseous involvement. Patients are rural workers living in areas situated far from medical centers. Too often, they reach well-equipped hospitals with advanced mutilating lesions. Early case detection is the first condition for good therapeutic results. Clinical presentations of actinomycetoma and eumycetoma are similar, only biological diagnosis can distinguish the two etiological forms...
June 2016: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/27233662/role-of-a-nsaid-in-the-apparent-cure-of-a-fungal-mycetoma
#20
B Dupont, A Datry, S Poirée, A Canestri, S Boucheneb, E Fourniols
UNLABELLED: We report the case of a fungal mycetoma due to Madurella mycetomatis that failed to respond to surgery and antifungal treatment but responded strongly to the addition of a non-steroidal anti-inflammatory drug (NSAID). This African patient was born in Mauritania in 1972. He was a herdsman, living close to the Senegal River. The first nodules appeared on the left foot at the age of 13years (1985). The patient suffered frequent flare-ups with the appearance of black grains and underwent surgery in 1988 and 1992 in Senegal...
June 2016: Journal de Mycologie Médicale
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