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Calcinosis cutis

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https://www.readbyqxmd.com/read/27833984/a-case-of-a-generalized-symptomatic-calcinosis-in-systemic-sclerosis
#1
Cristian Radu Jecan, Ştefan Iulian Bedereag, Ruxandra Diana Sinescu, Valentin Titus Grigorean, Cristina Nicoleta Cozma, Anca Bordianu, Ioan Petre Florescu
Calcinosis consists of abnormal calcium deposition in soft tissues, which appears often in patients with limited systemic sclerosis, being one of the criteria of CREST (calcinosis cutis, Raynaud phenomenon, esophageal dysfunction, sclerodactyly, and telangiectasia) syndrome. With a long evolution, the aim of the treatment is to control the symptoms and prevent complications. In this article, we present the challenging management of a profuse lesion of calcinosis in a patient with systemic sclerosis. We describe the case of a 52-year-old woman with systemic sclerosis and CREST syndrome who was admitted in our Department with multiple painful and disabling tumoral masses, situated in nearly all joints...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/27828644/milia-like-calcinosis-cutis-in-a-girl-with-down-syndrome
#2
Berna Solak, Rabia Oztas Kara, Erdem Vargol
Milia-like idiopathic calcinosis cutis (MICC) is a very rare dermatological disorder characterized by multiple whitish to skin colored, milia-like papules, mostly found on the hands. MICC can disappear spontaneously by adulthood; therefore, its early recognition is crucial to avoiding unnecessary interventions. Herein, we present a case of MICC in a 6-year-old girl with Down syndrome.
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/27756992/iatrogenic-calcinosis-cutis-a-rare-cytological-diagnosis
#3
Gopal Krishna Sawke, Tina Rai, Nilima Sawke
Calcinosis cutis is an uncommon condition characterized by the deposition of calcium salts in the subcutaneous tissues of the body. Calcifications can also occur in a variety of other clinical settings and can be subjected to fine-needle aspiration (FNA). Since cutaneous calcific deposits may clinically mimic a tumor, it is feasible to diagnose them by FNA cytology (FNAC). We reported a case of calcinosis cutis by FNA in a 36-year-old male who presented with a solitary subcutaneous nodule in cubital fossa. Smears showed amorphous granular material consistent with calcium and occasional histiocytes...
July 2016: Journal of Cytology
https://www.readbyqxmd.com/read/27703483/the-association-of-pseudohypoparathyroidism-type-ia-with-chiari-malformation-type-i-a-coincidence-or-a-common-link
#4
Paria Kashani, Madan Roy, Linda Gillis, Olufemi Ajani, M Constantine Samaan
A 19-month-old boy was referred for progressive weight gain. His past medical history included congenital hypothyroidism and developmental delay. Physical examination revealed characteristics of Albright Hereditary Osteodystrophy, macrocephaly, and calcinosis cutis. He had hypocalcemia, hyperphosphatemia, and elevated Parathyroid Hormone levels. Genetic testing revealed a known mutation of GNAS gene, confirming the diagnosis of Pseudohypoparathyroidism Type Ia (PHP-Ia) (c.34C>T (p.G1n12X)). He had a normal brain MRI at three months, but developmental delay prompted a repeat MRI that revealed Chiari Malformation Type I (CM-I) with hydrocephalus requiring neurosurgical intervention...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27665458/asia-syndrome-calcinosis-cutis-and-chronic-kidney-disease-following-silicone-injections-a-case-based-review
#5
Giuseppe Barilaro, Claudia Spaziani Testa, Antonella Cacciani, Giuseppe Donato, Mira Dimko, Amalia Mariotti
An immunologic adjuvant is a substance that enhances the antigen-specific immune response preferably without triggering one on its own. Silicone, a synthetic polymer used for reconstructive and cosmetic purposes, can cause, once injected, local and/or systemic reactions and trigger manifestations of autoimmunity, occasionally leading to an overt autoimmune disease. Siliconosis, calcinosis cutis with hypercalcemia and chronic kidney disease have all been reported in association with silicone injection. Here, we describe a case of autoimmune/auto-inflammatory syndrome induced by adjuvants, calcinosis cutis and chronic kidney disease after liquid silicone multiple injections in a young man who underwent a sex reassignment surgery, followed by a review of the literature...
September 24, 2016: Immunologic Research
https://www.readbyqxmd.com/read/27660938/a-novel-approach-in-the-treatment-of-calcinosis-cutis
#6
Robert Hawkins, Ricky Mehta
No abstract text is available yet for this article.
October 2016: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/27617523/milia-like-idiopathic-calcinosis-cutis-in-a-child-with-down-syndrome
#7
Piyush Kumar, Sushil S Savant, Esther Nimisha, Anupam Das, Panchami Debbarman
Idiopathic calcinosis cutis refers to progressive deposition of crystals of calcium phosphate in the skin and other areas of the body, in the absence of any inciting factor. Idiopathic calcinosis cutis may sometimes take the form of small, milia-like lesions. Most commonly, such milia like lesions are seen in the setting of Down syndrome. Herein, we report a 5-year-old girl with multiple asymptomatic discrete milia-like firm papules distributed over the face and extremities. A diagnosis of milia-like idiopathic calcinosis cutis associated with Down Syndrome was provisionally made and was confirmed by histopathology and karyotyping...
2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/27507016/calcinosis-cutis-universalis
#8
Andreas Körber, Joachim Dissemond
No abstract text is available yet for this article.
August 9, 2016: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/27494629/safety-and-efficacy-of-extracorporeal-shock-wave-therapy-eswt-in-calcinosis-cutis-associated-with-systemic-sclerosis
#9
Sandra Blumhardt, Diana P Frey, Martin Toniolo, Hatem Alkadhi, Ulrike Held, Oliver Distler
OBJECTIVES: Calcinosis cutis is a frequent, difficult to treat manifestation of systemic sclerosis (SSc) associated with high morbidity. The aim of this prospective, controlled, monocentric study was to assess safety and efficacy of extracorporeal shock wave therapy (ESWT) for calcinosis cutis of the finger in SSc patients. METHODS: A 12-week proof of concept study in which 4 SSc patients with calcinosis cutis were treated at one painful finger with high-energy, focused ESWT, in 3 sessions with one-week interval between each session...
September 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27479867/subepidermal-calcified-nodules-of-the-eyelid-differ-in-children-and-adults
#10
Saeed AlWadani, Maria J Suarez, Jonathan J Kass, Emily MacQuaid, Deepak P Edward, Hind Alkatan, Charles Eberhart
PURPOSE: Subepidermal calcified nodule of the eyelid is considered as one of the types of calcinosis cutis. It generally occurs in children, and is not known to be associated with systemic disease. The authors report histopathological and clinical findings in 14 cases of subepidermal calcified nodule of the eyelid, including 3 older patients with unique microscopic features. METHODS: Clinical records and pathological materials were critically reviewed in each case, including von kossa, CD3, CD20, and CD68 stains...
July 29, 2016: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27312381/digital-ulcers-and-cutaneous-subsets-of-systemic-sclerosis-clinical-immunological-nailfold-capillaroscopy-and-survival-differences-in-the-spanish-rescle-registry
#11
Carles Tolosa-Vilella, Maria Lluisa Morera-Morales, Carmen Pilar Simeón-Aznar, Begoña Marí-Alfonso, Dolores Colunga-Arguelles, José Luis Callejas Rubio, Manuel Rubio-Rivas, Maika Freire-Dapena, Alfredo Guillén-Del Castillo, Nerea Iniesta-Arandia, Maria Jesús Castillo-Palma, Marivi Egurbide-Arberas, Luis Trapiellla-Martínez, José A Vargas-Hitos, José Antonio Todolí-Parra, Mónica Rodriguez-Carballeira, Adela Marin-Ballvé, Xavier Pla-Salas, Juan José Rios-Blanco, Vicent Fonollosa-Pla
OBJECTIVE: Digital ulcers (DU) are the most common vascular complication of systemic sclerosis (SSc). We compared the characteristics between patients with prior or current DU with those never affected and evaluated whether a history of DU may be a predictor of vascular, organ involvement, and/or death in patients with SSc. METHODS: Data from SSc patients with or without prior or current DU were collected by 19 referral centers in an ongoing registry of Spanish SSc patients, named Registro de ESCLErodermia (RESCLE)...
October 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/27274638/tumoral-calcinosis-as-an-initial-complaint-of-juvenile-onset-amyopathic-dermatomyositis
#12
Eun Jin Doh, Jungyoon Moon, Sue Shin, Soo Hyun Seo, Hyun Sun Park, Hyun-Sun Yoon, Soyun Cho
Calcinosis is rarely observed in juvenile-onset amyopathic dermatomyositis in contrast to juvenile-onset dermatomyositis. A 6-year-old female presented with several 0.5 to 2 cm-sized painless grouped masses on both knees for 3 years. The patient also presented with multiple erythematous scaly patches and plaques on both elbows, knuckles, buttock, ankles and cheeks. Her mother had similar skin lesions which were erythematous scaly patches on the knuckles and elbows, since her childhood. When skin biopsy was performed from a left knee nodule, liquid chalky discharge was observed...
June 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27241784/heel-stick-calcinosis-cutis
#13
Matthew Galas, Joseph M Lam
No abstract text is available yet for this article.
September 6, 2016: CMAJ: Canadian Medical Association Journal, Journal de L'Association Medicale Canadienne
https://www.readbyqxmd.com/read/27164190/phenotypic-and-genotypic-characterization-and-treatment-of-a-cohort-with-familial-tumoral-calcinosis-hyperostosis-hyperphosphatemia-syndrome
#14
Mary Scott Ramnitz, Pravitt Gourh, Raphaela Goldbach-Mansky, Felasfa Wodajo, Shoji Ichikawa, Michael J Econs, Kenneth E White, Alfredo Molinolo, Marcus Y Chen, Theo Heller, Jaydira Del Rivero, Patricia Seo-Mayer, Bita Arabshahi, Malaka B Jackson, Sarah Hatab, Edward McCarthy, Lori C Guthrie, Beth A Brillante, Rachel I Gafni, Michael T Collins
Familial tumoral calcinosis (FTC)/hyperostosis-hyperphosphatemia syndrome (HHS) is a rare disorder caused by mutations in the genes encoding fibroblast growth factor-23 (FGF23), N-acetylgalactosaminyltransferase 3 (GALNT3), or KLOTHO. The result is functional deficiency of, or resistance to, intact FGF23 (iFGF23), causing hyperphosphatemia, increased renal tubular reabsorption of phosphorus (TRP), elevated or inappropriately normal 1,25-dihydroxyvitamin D3 (1,25D), ectopic calcifications, and/or diaphyseal hyperostosis...
October 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27051724/discoid-lupus-erythematosus-with-dystrophic-calcinosis-cutis
#15
Ayumi Korekawa, Koji Nakajima, Takahide Kaneko, Hajime Nakano, Daisuke Sawamura
No abstract text is available yet for this article.
July 2015: JAAD Case Reports
https://www.readbyqxmd.com/read/27019816/iatrogenic-calcinosis-cutis-of-the-upper-limb-arising-from-the-extravasation-of-intravenous-anticancer-drugs-in-a-patient-with-acute-lymphoblastic-leukemia
#16
Eui Han Chung, Young Hwan Kim
No abstract text is available yet for this article.
March 2016: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/26992073/worsening-of-calcinosis-cutis-with-teriparatide-treatment-in-two-osteoporotic-patients
#17
A F Echeverri, F E Ospina, C A Cañas, A Agualimpia, J P Suso, G J Tobón, F Bonilla-Abadía
We present two cases of patients with systemic autoimmune diseases (one with dermatomyositis and the second one with CREST syndrome), who presented a worsening of calcinosis cutis after treatment of osteoporosis with teriparatide. To our knowledge, this association is not described in the literature and might be considered in the spectrum of adverse reactions to teriparatide. This article is protected by copyright. All rights reserved.
March 16, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/26904448/calcinosis-cutis-secondary-to-facial-acne-vulgaris-a-rare-complication
#18
Srimanta Kumar Sahu, Nikhil Gupta, Suruchi Vohra
Acne vulgaris is a common dermatological disease commonly affecting the adolescent and young adults. It is characterized by the presence of pleomorphic skin lesions such as comadones, papules, pustules, and nodules. The common complications are postacne hyperpigmentation and scarring causing psychological impact. Calcinosis cutis is the pathologic deposition of insoluble calcium salt in the skin and subcutaneous tissue. Calcinosis cutis following acne vulgaris is rarely reported in the literature. We report a case of calcinosis cutis in acne vulgaris in a 55-year-old man...
December 2015: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/26873649/diffuse-calcinosis-cutis-in-systemic-lupus-erythematosus-an-exceptional-complication
#19
EDITORIAL
S Soudet, E Delaporte, P Y Hatron
No abstract text is available yet for this article.
August 2016: Lupus
https://www.readbyqxmd.com/read/26862141/severe-dystrophic-calcinosis-cutis-with-tumor-like-nodules
#20
Steven M Dean
No abstract text is available yet for this article.
August 2016: Vascular Medicine
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