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Myopericytoma

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https://www.readbyqxmd.com/read/27832007/myopericytoma-of-the-internal-auditory-canal
#1
Jacob B Hunter, Brendan P O'Connell, Woon N Chow, Kyle D Weaver, Justin M Cates, George B Wanna
No abstract text is available yet for this article.
November 9, 2016: Otology & Neurotology
https://www.readbyqxmd.com/read/27776010/recurrent-somatic-pdgfrb-mutations-in-sporadic-infantile-solitary-adult-myofibromas-but-not-in-angioleiomyomas-and-myopericytomas
#2
Abbas Agaimy, Matthias Bieg, Michael Michal, Helene Geddert, Bruno Märkl, Jan Seitz, Evgeny A Moskalev, Matthias Schlesner, Markus Metzler, Arndt Hartmann, Stefan Wiemann, Michal Michal, Thomas Mentzel, Florian Haller
Infantile myofibroma (MF) is an uncommon benign myofibroblastic tumor of infancy and childhood. Solitary adult MF shares similar features with infantile MF. The lesions occur in 3 clinicopathologic settings: solitary, multicentric, and generalized and can be either sporadic or familial. Traditionally, infantile MF has been included in the spectrum of infantile hemangiopericytoma. The recent World Health Organization classification listed MF, angioleiomyoma, and myopericytoma under the general heading of perivascular tumors in the sense of a morphologic spectrum of perivascular myoid cell neoplasms...
October 21, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27568674/myopericytoma-a-unifying-term-or-a-unique-entity
#3
Z S Jairajpuri, M J Hasan, G B Madan, S Jetley
Myopericytoma are uncommon, slow-growing benign perivascular neoplasms that show hemangiopericytoma-like vascular pattern. We report a 52-year-male patient with a painless palpable nodule in the left thumb for the past 9 months. The mass, on the thenar aspect, was 15x12mm in size. X-ray revealed a soft tissue swelling with no bony association. The excised nodule was a non-capsulated, well-circumscribed vascular neoplasm composed of proliferating spindle to ovoid bland cells with eosinophilic cytoplasm. A concentric perivascular arrangement of the cells was seen interspersed by thin-walled, branching, staghorn blood vessels...
August 2016: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/27423414/mirna-expression-profiling-divides-follicular-dendritic-cell-sarcomas-into-two-groups-related-to-fibroblasts-and-myopericytomas-or-castleman-s-disease
#4
Sylvia Hartmann, Claudia Döring, Claudio Agostinelli, Soo-Jeong Portscher-Kim, Silvia Lonardi, Luisa Lorenzi, Fabio Fuligni, Daniel Martinez, Jay Mehta, Anita Borges, Holger Hackstein, Stefan Kippenberger, Pier Paolo Piccaluga, Ingrid Simonitsch-Klupp, José Cabeçadas, Elias Campo, Fabio Facchetti, Stefano A Pileri, Martin-Leo Hansmann
Follicular dendritic cell (FDC) sarcomas are rare mesenchymal tumours, which are fatal in 20% of the patients and usually occur in secondary lymphoid organs or extranodal localizations. Due to the rareness of these tumours, only few studies have been conducted on molecular level. In the present study, we performed microRNA (miRNA) profiling of 31 FDC sarcomas and identified two subgroups, one with high miRNA expression and the other group with low miRNA expression levels. The first group showed a strong similarity to fibroblasts and myopericytomas, whereas the second group was more closely related to FDCs from Castleman's disease...
September 2016: European Journal of Cancer
https://www.readbyqxmd.com/read/27398322/malignant-myopericytoma-of-shoulder-a-rare-lesion
#5
Fariba Binesh, Reza Nafisi Moghadam, Masoud Shabani, Mohammad Reza Mortazavizadeh, Saeedeh Zare
Myopericytoma is a soft tissue tumor with perivascular myoid differentiation. It accounts for 1% of the vascular tumors and involves mostly cutaneous or subcutaneous tissue of the limbs in adults. Malignant myopericytoma is exceedingly rare. A 15-year old girl presented with slowly progressive mass over left shoulder region. Histopathology and immunohistochemistry after complete excision revealed it as malignant myopericytoma.
July 2016: APSP Journal of Case Reports
https://www.readbyqxmd.com/read/27325236/nuclear-%C3%AE-catenin-expression-is-frequent-in-sinonasal-hemangiopericytoma-and-its-mimics
#6
Vickie Y Jo, Christopher D M Fletcher
Sinonasal hemangiopericytoma (HPC) is a tumor showing pericytic myoid differentiation and which arises in the nasal cavity and paranasal sinuses. CTNNB1 mutations appear to be a consistent aberration in sinonasal HPC, and nuclear expression of β-catenin has been reported. Our aim was to evaluate the frequency of β-catenin expression in sinonasal HPC and its histologic mimics in the upper aerodigestive tract. Cases were retrieved from the surgical pathology and consultation files. Immunohistochemical staining for β-catenin was performed on 50 soft tissue tumors arising in the sinonasal tract or oral cavity, and nuclear staining was recorded semiquantitatively by extent and intensity...
June 20, 2016: Head and Neck Pathology
https://www.readbyqxmd.com/read/27124684/incidental-detection-of-subcutaneous-myopericytoma-of-trunk-on-fdg-pet-ct-and-bone-scintigraphy-for-imaging-of-colon-cancer
#7
Selin Soyluoglu Demir, Ali Sarikaya, Gul Ege Aktas, Fulya Oz Puyan
Myopericytoma is a rare type of unusual soft tissue tumor with perivascular myoid differentiation. A 53-year-old man with the diagnosis of colon cancer was referred to Tc-MDP bone scan and F-FDG PET/CT for staging. A subcutaneous mass located in right lower back with heterogeneous FDG uptake was detected on PET/CT. There was increased osteoblastic activity on MDP bone scan in the same region. Mass was resected and subsequently confirmed as myopericytoma by histopathology.
August 2016: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27074874/cd34-positive-infantile-myofibromatosis-case-report-and-review-of-hemangiopericytoma-like-pattern-tumors
#8
Takahiro Kiyohara, Naoki Maruta, Shiro Iino, Hideki Ido, Atsushi Tokuriki, Minoru Hasegawa
We describe a case of CD34-positive infantile myofibromatosis with hemangiopericytoma-like pattern. A 2-day-old Japanese boy presented with multiple hemispherical nodules on the extremities and back. There was a biphasic histological growth in the dermis, accompanied by a hemangiopericytoma-like pattern with antler-like branching vessels. Tumor cells were oval to spindle-shaped myoid cells with bland appearance. Immunohistochemically, vimentin, calponin and CD34 were positive, while α-smooth muscle actin, h-caldesmon, HHF35 and desmin were negative...
September 2016: Journal of Dermatology
https://www.readbyqxmd.com/read/27063472/pericytic-mimicry-in-well-differentiated-liposarcoma-atypical-lipomatous-tumor
#9
Jia Shen, Swati Shrestha, P Nagesh Rao, Greg Asatrian, Michelle A Scott, Vi Nguyen, Paulina Giacomelli, Chia Soo, Kang Ting, Fritz C Eilber, Bruno Peault, Sarah M Dry, Aaron W James
Pericytes are modified smooth muscle cells that closely enwrap small blood vessels, regulating and supporting the microvasculature through direct endothelial contact. Pericytes demonstrate a distinct immunohistochemical profile, including expression of smooth muscle actin, CD146, platelet-derived growth factor receptor β, and regulator of G-protein signaling 5. Previously, pericyte-related antigens have been observed to be present among a group of soft tissue tumors with a perivascular growth pattern, including glomus tumor, myopericytoma, and angioleiomyoma...
August 2016: Human Pathology
https://www.readbyqxmd.com/read/27061437/myopericytoma-arising-adjacent-to-the-common-carotid-artery-case-report-and-systematic-review-of-deep-located-neck-myopericytomas
#10
Héctor M Prado-Calleros, David Galarza-Lozano, José R Arrieta-Gómez, Alejandro Pombo-Nava, Sara Parraguirre-Martínez, Carlos Jiménez Gutiérrez
BACKGROUND: Myopericytoma is a perivascular tumor of the skin and subcutaneous tissue of the extremities, it is a rare finding in the head and neck, and even rarer is its deep location. METHODS: A 38-year-old woman presented with a slowly growing mass at the right carotid triangle. Contrast-enhanced CT scan revealed a moderately enhancing mass. At surgery, the tumor was firmly attached to the common carotid artery, making it necessary to excise a small portion of the vessel wall...
September 2016: Head & Neck
https://www.readbyqxmd.com/read/26993809/primary-benign-myopericytoma-of-the-left-atrium
#11
Tomás Francisco Cianciulli, Jorge Alberto Lax, María Cristina Saccheri, Juan Pablo Lestard, Martín Hernán Medawar, Andrea Zappi, Roberto Osvaldo Neme
No abstract text is available yet for this article.
September 2016: Journal of Echocardiography
https://www.readbyqxmd.com/read/26959697/intravascular-myopericytoma-of-the-plantar-region-case-report-and-discussion-of-the-probable-origin-from-a-cutaneous-vascular-malformation
#12
Jaime Agustí, Lucas Peñas, Nuria Bosch
Myopericytoma is a perivascular myoid neoplasm of skin and soft tissues characterized by numerous thin-walled blood vessels surrounded concentrically by round to spindle myoid tumor cells, which shows α-smooth muscle actin and h-caldesmon coexpression and commonly negativity for desmin. These tumors arise predominantly in extremities of adult patients with benign clinical course. Based on the architectural pattern, there are various histologic variants as classical-solid myopericytoma, hemangiopericytoma-like myopericytoma, angioleiomyoma-like myopericytoma, myofibroma-like myopericytoma, hipocelular fibroma-like myopericytoma, intravascular myopericytoma, cellular immature myopericytoma, and malignant myopericytoma...
July 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/26863915/paediatric-and-adult-soft-tissue-sarcomas-with-ntrk1-gene-fusions-a-subset-of-spindle-cell-sarcomas-unified-by-a-prominent-myopericytic-haemangiopericytic-pattern
#13
Florian Haller, Jasmin Knopf, Anne Ackermann, Matthias Bieg, Kortine Kleinheinz, Matthias Schlesner, Evgeny A Moskalev, Rainer Will, Ali Abdel Satir, Ibtihalat E Abdelmagid, Johannes Giedl, Roman Carbon, Oliver Rompel, Arndt Hartmann, Stefan Wiemann, Markus Metzler, Abbas Agaimy
Neoplasms with a myopericytomatous pattern represent a morphological spectrum of lesions encompassing myopericytoma of the skin and soft tissue, angioleiomyoma, myofibromatosis/infantile haemangiopericytoma and putative neoplasms reported as malignant myopericytoma. Lack of reproducible phenotypic and genetic features of malignant myopericytic neoplasms have prevented the establishment of myopericytic sarcoma as an acceptable diagnostic category. Following detection of a LMNA-NTRK1 gene fusion in an index case of paediatric haemangiopericytoma-like sarcoma by combined whole-genome and RNA sequencing, we identified three additional sarcomas harbouring NTRK1 gene fusions, termed 'spindle cell sarcoma, NOS with myo/haemangiopericytic growth pattern'...
April 2016: Journal of Pathology
https://www.readbyqxmd.com/read/26863056/malignant-myopericytoma-report-of-a-new-case-and-review-of-the-literature
#14
Agostini Patrick, Luís Soares-de-Almeida, Kutzner Heinz
Malignant myopericytoma is a rare entity with only 8 cases reported in the English literature. The authors report a case of a 65-year-old man with a slow-growing 8-cm nodule on the right arm. Marginal excision was performed, and a diagnosis of malignant myopericytoma was made based on histopathologic and immunohistochemical aspects. These tumors are characterized by a proliferation of round-to-spindle cells of myoid appearance in a concentric perivascular arrangement, along with malignant cytological findings...
April 2016: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/26691377/ultrastructure-and-histogenesis-of-the-acral-calcified-angioleiomyoma
#15
Lucio Díaz-Flores, Ricardo Gutiérrez, Hugo Alvarez-Argüelles, Miriam González-Gómez, Maria Del Pino García, Lucio Díaz-Flores
We studied the ultrastructure, immunohistochemistry, and histogenesis of the acral calcified angioleiomyoma, observing three concentric zones: (a) pseudocapsular, thin, with spindle-shaped stromal cells (SCs), presenting scarce organelles and expressing CD34, (b) muscular, forming a ring, with smooth muscle cells of heterogenous phenotype (mainly in quantity and thickness of filaments, and in expression of h-caldesmon, αSMA, and desmin), and (c) central, extensive, calcified (spicular and/or star-shaped calcium deposits around collagen fibers), with pericytic involutive vasculature...
2016: Ultrastructural Pathology
https://www.readbyqxmd.com/read/26558691/the-pericyte-antigen-rgs5-in-perivascular-soft-tissue-tumors
#16
Jia Shen, Swati Shrestha, Yu-Hsin Yen, Michelle A Scott, Chia Soo, Kang Ting, Bruno Peault, Sarah M Dry, Aaron W James
Perivascular soft tissue tumors are relatively uncommon neoplasms of unclear lineage of differentiation, although most are presumed to originate from or differentiate to pericytes or a modified perivascular cell. Among these, glomus tumor, myopericytoma, and angioleiomyoma share a spectrum of histologic findings and a perivascular growth pattern. In contrast, solitary fibrous tumor was once hypothesized to have pericytic differentiation--although little bona fide evidence of pericytic differentiation exists...
January 2016: Human Pathology
https://www.readbyqxmd.com/read/26191123/renal-myopericytoma-a-clinicopathologic-study-of-six-cases-and-review-of-the-literature
#17
REVIEW
Jun Li, Ming Zhao, Zhen Chen, Liang Zou, Xiaodong Teng
To evaluate the morphologic features, immunohistochemical profiles, and biological behavior of renal myopericytoma. Six cases of renal myopericytoma are retrospectively retrieved and analyzed by H&E and immunohistochemical staining. Clinically, patient's age ranged from 33 to 70 years (median, 56 years). Male to female ratio was 5:1. Five of the six patients were asymptomatic of the urinary tract, the remained one presented with abdomen pain. Grossly, all six tumors were solitary masses with sizes ranging from 1...
2015: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/26085647/pericyte-antigens-in-perivascular-soft-tissue-tumors
#18
Jia Shen, Swati Shrestha, Yu-Hsin Yen, Greg Asatrian, Marco Mravic, Chia Soo, Kang Ting, Sarah M Dry, Bruno Peault, Aaron W James
INTRODUCTION: Perivascular soft tissue tumors are relatively uncommon neoplasms of unclear line of differentiation, although most are presumed to originate from pericytes or modified perivascular cells. Among these, glomus tumor, myopericytoma, and angioleiomyoma share a spectrum of histologic findings and a perivascular growth pattern. In contrast, solitary fibrous tumor (previously termed hemangiopericytoma) was once hypothesized to have pericytic differentiation. METHODS: Here, we systematically examine pericyte immunohistochemical markers among glomus tumor (including malignant glomus tumor), myopericytoma, angioleiomyoma, and solitary fibrous tumor...
December 2015: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/26068635/myopericytoma-tumor-of-the-glans-penis
#19
Dayron Rodríguez, Kristine M Cornejo, Peter M Sadow, Yahir Santiago-Lastra, Adam S Feldman
Myopericytoma is a low grade spindle cell neoplasm largely occurring in skin. We describe the first reported case of a penile myopericytoma. Histologically, the penile tumor was composed of a perivascular proliferation of tumor cells with ovoid shaped nuclei and abundant eosinophilic cytoplasm. Immunohistochemically, the tumor was reactive for markers of smooth muscle differentiation and vascular differentiation. The tumor was noted to be negative for BRAF by immunohistochemistry and wild-type upon gene sequencing using SnaPshot...
June 2015: Canadian Journal of Urology
https://www.readbyqxmd.com/read/26034459/myopericytoma-of-the-hypothenar-eminence-case-report
#20
Eric R Wagner, Alexander Y Shin
Myopericytomas belong to a benign group of tumors consisting of perivascular myopericytes or pericytes with a characteristic myoid differentiation pattern. The tumor is histologically and radiographically heterogenous, similar to superficial myofibromas. We report on a case of a myopericytoma arising in the hypothenar eminence of a 58-year-old man with a history of over 15 years of ulnar-sided and midcarpal wrist pain. Decision was made to excise the mass after it had increased in size by over 50 % over a 10-year period...
June 2015: Hand: Official Journal of the American Association for Hand Surgery
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