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AMEE Guide

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https://www.readbyqxmd.com/read/28047420/su-f-j-57-effectiveness-of-daily-ct-based-three-dimensional-image-guided-and-adaptive-proton-therapy
#1
S Moriya, H Tachibana, K Hotta, N Nakamura, H Baba, R Kohno, S Miyakawa, T Kurosawa, T Akimoto
PURPOSE: Daily CT-based three-dimensional image-guided and adaptive (CTIGRT-ART) proton therapy system was designed and developed. We also evaluated the effectiveness of the CTIGRT-ART. METHODS: Retrospective analysis was performed in three lung cancer patients: Proton treatment planning was performed using CT image datasets acquired by Toshiba Aquilion ONE. Planning target volume and surrounding organs were contoured by a well-trained radiation oncologist. Dose distribution was optimized using 180-deg...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27965837/optimisation-of-complex-health-interventions-prior-to-a-randomised-controlled-trial-a-scoping-review-of-strategies-used
#2
REVIEW
Sara Levati, Pauline Campbell, Rachael Frost, Nadine Dougall, Mary Wells, Cam Donaldson, Suzanne Hagen
BACKGROUND: Many complex intervention trials fail to show an intervention effect. Although this may be due to genuine ineffectiveness, it may also be the result of sub-optimal intervention design, implementation failure or a combination of these. Given current financial constraints and the pressure to reduce waste and increase value in health services research, pre-trial strategies are needed to reduce the likelihood of design or implementation failure and to maximise the intervention's potential for effectiveness...
2016: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/27936603/quantitative-trait-loci-qtl-guided-metabolic-engineering-of-a-complex-trait
#3
Matthew J Maurer, Lawrence Sutardja, Dominic Pinel, Stefan Bauer, Amanda L Muehlbauer, Tyler D Ames, Jeffrey M Skerker, Adam P Arkin
Engineering complex phenotypes for industrial and synthetic biology applications is difficult and often confounds rational design. Bioethanol production from lignocellulosic feedstocks is a complex trait that requires multiple host systems to utilize, detoxify, and metabolize a mixture of sugars and inhibitors present in plant hydrolysates. Here, we demonstrate an integrated approach to discovering and optimizing host factors that impact fitness of Saccharomyces cerevisiae during fermentation of a Miscanthus x giganteus plant hydrolysate...
December 28, 2016: ACS Synthetic Biology
https://www.readbyqxmd.com/read/27927522/adult-spinal-deformity-epidemiology-health-impact-evaluation-and-management
#4
Christopher P Ames, Justin K Scheer, Virginie Lafage, Justin S Smith, Shay Bess, Sigurd H Berven, Gregory M Mundis, Rajiv K Sethi, Donald A Deinlein, Jeffrey D Coe, Lloyd A Hey, Michael D Daubs
Spinal deformity in the adult is a common medical disorder with a significant and measurable impact on health-related quality of life. The ability to measure and quantify patient self-reported health status with disease-specific and general health status measures, and to correlate health status with radiographic and clinical measures of spinal deformity, has enabled significant advances in the assessment of the impact of deformity on our population, and in the evaluation and management of spinal deformity using an evidence-based approach...
July 2016: Spine Deformity
https://www.readbyqxmd.com/read/27852144/appreciative-inquiry-in-medical-education
#5
John Sandars, Deborah Murdoch-Eaton
The practice of medicine, and also medical education, typically adopts a problem-solving approach to identify "what is going wrong" with a situation. However, an alternative is Appreciative Inquiry (AI), which adopts a positive and strengths-based approach to identify "what is going well" with a situation. The AI approach can be used for the development and enhancement of the potential of both individuals and organizations. An essential aspect of the AI approach is the generative process, in which a new situation is envisioned and both individual and collective strengths are mobilized to make changes to achieve the valued future situation...
November 17, 2016: Medical Teacher
https://www.readbyqxmd.com/read/27834675/conservative-treatments-for-greater-trochanteric-pain-syndrome-a-systematic-review
#6
Paul A Barratt, Nathan Brookes, Annalisa Newson
BACKGROUND: Greater trochanteric pain syndrome (GTPS) can have a significant effect on quality of life. AIM: To evaluate the conservative treatments for GTPS. DESIGN: This systematic review assessed risk of bias using the Cochrane Risk of Bias Tool and Cochrane Risk of Bias Tool for non-randomised studies of interventions. DATA SOURCES: On 13 January 2016, a comprehensive search was conducted, with no limit on year of publication for relevant studies in the MEDLINE, CINAHL, AMED and EMBASE databases...
November 10, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27816862/the-utility-and-impact-of-information-communication-technology-ict-for-pre-registration-nurse-education-a-narrative-synthesis-systematic-review
#7
REVIEW
Lucy Webb, Jonathan Clough, Declan O'Reilly, Danita Wilmott, Gary Witham
OBJECTIVES: To evaluate and summarise the utility and impact of information communication technology (ICT) in enhancing student performance and the learning environment in pre-registration nursing. DESIGN: A systematic review of empirical research across a range of themes in ICT health-related education. DATA SOURCES: Science Direct, Cinahl, AMED, MEDLINE, PubMed, ASSIA, OVID and OVID SP (2008-2014). Further date parameters were imposed by theme...
January 2017: Nurse Education Today
https://www.readbyqxmd.com/read/27774351/impact-of-a-10-minute-seated-yoga-practice-in-the-management-of-diabetes
#8
Rashmi S Mullur, Donna Ames
OBJECTIVE: We sought to prospectively evaluate the impact of a 10 minute seated yoga program added to standard comprehensive diabetes care on glucose control and cardiovascular health in the severely ill, medically complex diabetic population. METHOD: A total of 10 patients with type 2 diabetes, ages 49-77, with duration of diabetes >10 years and haemoglobin A1C >9% (75 mmol/mol) were included in the study. Patients randomized to a yoga intervention were taught a 10 minute seated yoga practice, were given an explanatory DVD and a fold-out pocket guide to encourage adherence at home, and were instructed to incorporate the practice as often as they could...
January 18, 2016: Journal of Yoga & Physical Therapy
https://www.readbyqxmd.com/read/27773722/prediction-of-pharmacokinetic-and-toxicological-parameters-of-a-4-phenylcoumarin-isolated-from-geopropolis-in-silico-and-in-vitro-approaches
#9
Marcos Guilherme da Cunha, Gilson César Nobre Franco, Marcelo Franchin, John A Beutler, Severino Matias de Alencar, Masaharu Ikegaki, Pedro Luiz Rosalen
In silico and in vitro methodologies have been used as important tools in the drug discovery process, including from natural sources. The aim of this study was to predict pharmacokinetic and toxicity (ADME/Tox) properties of a coumarin isolated from geopropolis using in silico and in vitro approaches. Cinnamoyloxy-mammeisin (CNM) isolated from Brazilian M. scutellaris geopropolis was evaluated for its pharmacokinetic parameters by in silico models (ACD/Percepta™ and MetaDrug™ software). Genotoxicity was assessed by in vitro DNA damage signaling PCR array...
November 30, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/27608933/producing-a-socially-accountable-medical-school-amee-guide-no-109
#10
Charles Boelen, David Pearson, Arthur Kaufman, James Rourke, Robert Woollard, David C Marsh, Trevor Gibbs
Health systems worldwide are confronted with challenges due to increased demand from their citizens, an aging population, a variety of health risks and limited resources. Key health stakeholders, including academic institutions and medical schools, are urged to develop a common vision for a more efficient and equitable health sector. It is in this environment that Boelen and Heck defined the concept of the "Social Accountability of Medical Schools" - a concept that encourages schools to produce not just highly competent professionals, but professionals who are equipped to respond to the changing challenges of healthcare through re-orientation of their education, research and service commitments, and be capable of demonstrating a positive effect upon the communities they serve...
September 9, 2016: Medical Teacher
https://www.readbyqxmd.com/read/27605692/reversible-intraoperative-neurophysiologic-monitoring-alerts-in-patients-undergoing-arthrodesis-for-adolescent-idiopathic-scoliosis-what-are-the-outcomes-of-surgery
#11
Amer F Samdani, James T Bennett, Robert J Ames, Jahangir K Asghar, Giuseppe Orlando, Joshua M Pahys, Burt Yaszay, Firoz Miyanji, Baron S Lonner, Ronald A Lehman, Peter O Newton, Patrick J Cahill, Randal R Betz
BACKGROUND: Confidence in intraoperative neurophysiologic monitoring (IONM) data can allow scoliosis surgeons to proceed with surgery even after a monitoring alert, assuming the recovery of signals. We sought to determine the outcomes of surgical treatment of adolescent idiopathic scoliosis (AIS) after a notable IONM alert. METHODS: We identified 676 patients who underwent arthrodesis with use of IONM for the treatment of AIS. The patients were divided into 2 cohorts: those who experienced a lower-extremity IONM alert and those who did not...
September 7, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27597323/writing-competitive-research-conference-abstracts-amee-guide-no-108
#12
Lara Varpio, Jonathan Amiel, Boyd F Richards
The ability to write a competitive research conference abstract is an important skill for medical educators. A compelling and concise abstract can convince peer reviewers, conference selection committee members, and conference attendees that the research described therein is worthy for inclusion in the conference program and/or for their attendance in the meeting. This AMEE Guide is designed to help medical educators write research conference abstracts that can achieve these outcomes. To do so, this Guide begins by examining the rhetorical context (i...
September 2016: Medical Teacher
https://www.readbyqxmd.com/read/27482609/italian-association-of-clinical-endocrinologists-statement-replacement-therapy-for-primary-hypothyroidism-a-brief-guide-for-clinical-practice
#13
Rinaldo Guglielmi, Andrea Frasoldati, Michele Zini, Franco Grimaldi, Hossein Gharib, Jeffrey R Garber, Enrico Papini
OBJECTIVE: Hypothyroidism requires life-long thyroid hormone replacement therapy in most patients. Oral levothyroxine (LT4) is an established safe and effective treatment for hypothyroidism, but some issues remain unsettled. METHODS: The Italian Association of Clinical Endocrinologists appointed a panel of experts to provide an updated statement for appropriate use of thyroid hormone formulations for hypothyroidism replacement therapy. The American Association of Clinical Endocrinologists' protocol for standardized production of clinical practice guidelines was followed...
November 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27338432/wayfinding-the-live-5-2-1-0-initiative-at-the-intersection-between-systems-thinking-and-community-based-childhood-obesity-prevention
#14
Shazhan Amed, Stephanie Shea, Susan Pinkney, Joan Wharf Higgins, Patti-Jean Naylor
Childhood obesity is complex and requires a 'systems approach' that collectively engages across multiple community settings. Sustainable Childhood Obesity Prevention through Community Engagement (SCOPE) has implemented Live 5-2-1-0-a multi-sector, multi-component childhood obesity prevention initiative informed by systems thinking and participatory research via an innovative knowledge translation (KT) model (RE-FRAME). This paper describes the protocol for implementing and evaluating RE-FRAME in two 'existing' (>2 years of implementation) and two 'new' Live 5-2-1-0 communities to understand how to facilitate and sustain systems/community-level change...
2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27209428/brazilian-oral-herbal-medication-for-osteoarthritis-a-systematic-review-protocol
#15
REVIEW
Mariana Del Grossi Moura, Luciane Cruz Lopes, Maique Weber Biavatti, Jason W Busse, Li Wang, Sean Alexander Kennedy, Neera Bhatnaga, Cristiane de Cássia Bergamaschi
BACKGROUND: Osteoarthritis affects 1 % of the world's population and is the most common cause of musculoskeletal impairment in the elderly. Herbal medications are commonly used in Brazil to manage symptoms associated with osteoarthritis, and some of them are financed by the Brazilian government; however, the effectiveness of most of these agents is uncertain. The aim was to systematically review the efficacy and safety of 13 oral herbal medications used in Brazil for the treatment of osteoarthritis...
May 21, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27167915/american-association-of-clinical-endocrinologists-american-college-of-endocrinology-and-associazione-medici-endocrinologi-medical-guidelines-for-clinical-practice-for-the-diagnosis-and-management-of-thyroid-nodules-2016-update
#16
Hossein Gharib, Enrico Papini, Jeffrey R Garber, Daniel S Duick, R Mack Harrell, Laszlo Hegedüs, Ralf Paschke, Roberto Valcavi, Paolo Vitti
Thyroid nodules are detected in up to 50 to 60% of healthy subjects. Most nodules do not cause clinically significant symptoms, and as a result, the main challenge in their management is to rule out malignancy, with ultrasonography (US) and fine-needle aspiration (FNA) biopsy serving as diagnostic cornerstones. The key issues discussed in these guidelines are as follows: (1) US-based categorization of the malignancy risk and indications for US-guided FNA (henceforth, FNA), (2) cytologic classification of FNA samples, (3) the roles of immunocytochemistry and molecular testing applied to thyroid FNA, (4) therapeutic options, and (5) follow-up strategy...
May 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27071739/residents-as-teachers-near-peer-learning-in-clinical-work-settings-amee-guide-no-106
#17
Subha Ramani, Karen Mann, David Taylor, Harish Thampy
This AMEE Guide provides a framework to guide medical educators engaged in the design and implementation of "Resident as Teacher" programs. The suggested approaches are based on established models of program development: the Program Logic model to guide program design, the Dundee three-circle model to inform a systematic approach to planning educational content and the Kirkpatrick pyramid, which forms the backbone of program evaluation. The Guide provides an overview of Resident as Teacher curricula, their benefits and impact, from existing literature supplemented by insights from the authors' own experiences, all of whom are engaged in teaching initiatives at their own institutions...
July 2016: Medical Teacher
https://www.readbyqxmd.com/read/27010681/mobile-technologies-in-medical-education-amee-guide-no-105
#18
Ken Masters, Rachel H Ellaway, David Topps, Douglas Archibald, Rebecca J Hogue
Mobile technologies (including handheld and wearable devices) have the potential to enhance learning activities from basic medical undergraduate education through residency and beyond. In order to use these technologies successfully, medical educators need to be aware of the underpinning socio-theoretical concepts that influence their usage, the pre-clinical and clinical educational environment in which the educational activities occur, and the practical possibilities and limitations of their usage. This Guide builds upon the previous AMEE Guide to e-Learning in medical education by providing medical teachers with conceptual frameworks and practical examples of using mobile technologies in medical education...
June 2016: Medical Teacher
https://www.readbyqxmd.com/read/27008030/aligning-physical-learning-spaces-with-the-curriculum-amee-guide-no-107
#19
Jonas Nordquist, Kristina Sundberg, Andrew Laing
This Guide explores emerging issues on the alignment of learning spaces with the changing curriculum in medical education. As technology and new teaching methods have altered the nature of learning in medical education, it is necessary to re-think how physical learning spaces are aligned with the curriculum. The better alignment of learning spaces with the curriculum depends on more directly engaged leadership from faculty and the community of medical education for briefing the requirements for the design of all kinds of learning spaces...
August 2016: Medical Teacher
https://www.readbyqxmd.com/read/26998657/the-supervisor-s-toolkit-a-framework-for-doctoral-supervision-in-health-professions-education-amee-guide-no-104
#20
Susan Camille van Schalkwyk, Deborah Murdoch-Eaton, Ara Tekian, Cees van der Vleuten, Francois Cilliers
Doctoral studies represent a complex undertaking for students and supervisors. Some research describes the experience of students while there are volumes of advice for students considering a doctorate. Yet the terrain for supervisors is less well-trodden and the concept of a pedagogy of supervision is only really starting to emerge. Texts on the doctoral journey from the supervisor's perspective are uncommon and less yet has been written in the context of health professions education. The aim of this Guide, therefore, is to provide guidance for the supervisor's journey, drawing on our collective experience and such literature as there is...
May 2016: Medical Teacher
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