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AMEE Guide

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https://www.readbyqxmd.com/read/28611451/beta-sitosterol-and-daucosterol-phytosterols-identified-in-grewia-tiliaefolia-perturbs-cell-cycle-and-induces-apoptotic-cell-death-in-a549-cells
#1
Tamilselvam Rajavel, Ramar Mohankumar, Govindaraju Archunan, Kandasamy Ruckmani, Kasi Pandima Devi
Lung cancer is the leading cause of cancer related deaths both in developed and developing countries. Since majority of the existing therapeutic methods harms both normal and malignant cells, a viable alternative is to switch into safe and beneficial traditional medicinal plants. Hence the present study was framed to identify selective anti-lung cancer agents from the medicinal plant Grewia tiliaefolia (GT). Cell viability experiments showed that benzene extract of GT (BGT) leaf effectively inhibited the growth of A549 cells, while being non-toxic to normal human lung L132 and PBMC cells...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28589088/a-2016-italian-survey-about-guidelines-and-clinical-management-of-thyroid-nodules
#2
Roberto Negro, Roberto Attanasio, Franco Grimaldi, Andrea Frasoldati, Rinaldo Guglielmi, Enrico Papini
BACKGROUND: While thyroid nodules are frequent in endocrine clinical practice, patients are often asymptomatic and euthyroid, and death is rare in cases of malignancy. OBJECTIVES: To evaluate the perception of current international guidelines regarding thyroid nodule management among Italian endocrinologists, and to compare daily clinical practice with suggested recommendations. METHODS: Italian Association of Clinical Endocrinologists (AME) members were invited to participate in a Web-based survey...
April 2017: European Thyroid Journal
https://www.readbyqxmd.com/read/28587511/diagnosis-and-management-of-clinical-reasoning-difficulties-part-ii-clinical-reasoning-difficulties-management-and-remediation-strategies
#3
Marie-Claude Audétat, Suzanne Laurin, Valérie Dory, Bernard Charlin, Mathieu R Nendaz
Part II of this AMEE Guide provides a detailed overview of the main difficulties in clinical reasoning, including the cues to look out for in clinical supervision, the root causes of each difficulty and targeted remediation strategies. Specific challenges and issues related to the management of clinical reasoning difficulties will also be discussed.
June 7, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28576479/aldosterone-breakthrough-in-dogs-with-naturally-occurring-myxomatous-mitral-valve-disease
#4
M K Ames, C E Atkins, A Eriksson, A M Hess
INTRODUCTION: Aldosterone breakthrough (ABT) is the condition in which angiotensin converting enzyme inhibitors (ACEIs) and/or angiotensin receptor blockers fail to effectively suppress the activity of the renin angiotensin aldosterone system. The objective of this study was to determine if ABT occurs in dogs with naturally occurring myxomatous mitral valve disease receiving an ACEI, using the urine aldosterone to creatinine ratio (UAldo:C) as a measure of renin angiotensin aldosterone system activation...
May 30, 2017: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/28558746/characteristics-of-therapeutic-alliance-in-musculoskeletal-physiotherapy-and-occupational-therapy-practice-a-scoping-review-of-the-literature
#5
Folarin Babatunde, Joy MacDermid, Norma MacIntyre
BACKGROUND: Most conventional treatment for musculoskeletal conditions continue to show moderate effects, prompting calls for ways to increase effectiveness, including drawing from strategies used across other health conditions. Therapeutic alliance refers to the relational processes at play in treatment which can act in combination or independently of specific interventions. Current evidence guiding the use of therapeutic alliance in health care arises largely from psychotherapy and medicine literature...
May 30, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28556476/neurophysiological-changes-associated-with-implant-associated-augmentation-procedures-in-the-lower-jaw
#6
Amely Hartmann, Claudia Welte-Jzyk, Marcus Seiler, Monika Daubländer
BACKGROUND: Neurophysiological changes after oral and maxillofacial surgery remain one of the topics of current research. PURPOSE: This study evaluated if implant placement associated with augmentation procedures increases the possibility of sensory disturbances or result in impaired quality of life during the healing period. MATERIAL AND METHODS: Patients who had obtained an implant placement in the lower jaw in combination with augmentation procedures were examined by implementing a comprehensive Quantitative Sensory Testing (QST) protocol for extra- and intraoral use...
May 29, 2017: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/28549899/utility-of-published-dna-reactivity-alerts
#7
Alun Myden, Sebastien J Guesne, Alex Cayley, Richard V Williams
The identification of impurities with mutagenic potential is required for any potential pharmaceutical. The ICH M7 guidelines state that two complementary in silico toxicity prediction tools may be used to predict the mutagenic potential of pharmaceutical impurities. An expert review of the resulting in silico predictions is required, and numerous publications have been released to guide the expert review process. One such publication suggests that literature-based structural alerts (LBSAs) may provide a suitable aid in the expert review process...
May 23, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28537752/imaging-features-of-spindle-cell-breast-lesions
#8
Andrew S Taliaferro, Valerie Fein-Zachary, Shambhavi Venkataraman, Tejas S Mehta, Amee Patel, Priscilla J Slanetz
OBJECTIVE: The purpose of our study is to review the clinical presentation, multimodality appearance, and management of the most common benign and malignant spindle cell lesions of the breast. CONCLUSION: Spindle cell lesions of the breast exhibit characteristic features at mammography, ultrasound, and MRI. Although a definitive diagnosis of these lesions cannot be made with diagnostic imaging alone, knowledge of their characteristic imaging features can assist in refining the differential diagnosis and guiding appropriate management...
May 24, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28438226/n-of-1-trials-and-the-optimal-individualisation-of-drug-treatments-a-systematic-review-protocol
#9
Weyinmi A Demeyin, Julia Frost, Obioha C Ukoumunne, Simon Briscoe, Nicky Britten
BACKGROUND: Guidelines and evidence-based drug treatment recommendations are usually based on the results of clinical trials, which have limited generalisability in routine clinical settings due to their restrictive eligibility criteria. These trials are also conducted in ideal and rigorously controlled settings. N of 1 trials, which are single patient multiple crossover studies, offer a means of increasing the evidence base and individualising care for individuals in clinical practice...
April 24, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28409089/comparative-effectiveness-of-guided-weight-loss-and-physical-activity-monitoring-for-weight-loss-and-metabolic-risks-a-pilot-study
#10
Karissa L Peyer, Laura D Ellingson, Kathryn Bus, Sarah A Walsh, Warren D Franke, Gregory J Welk
Many consumer-based physical activity monitors (PAMs) are available but it is not clear how to use them to most effectively promote weight loss. The purpose of this pilot study was to compare the effectiveness of a personal PAM, a guided weight loss program (GWL), and the combination of these approaches on weight loss and metabolic risk. Participants completed the study in two cohorts: Fall 2010 and Spring 2011. A sample of 72 obese individuals in the Ames, IA area were randomized to one of 3 conditions: 1) (GWL, N = 31), 2) PAM, N = 29, or 3) a combination group (PAM + GWL, N = 29)...
June 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28399427/clinical-and-cost-effectiveness-of-nurse-led-self-management-interventions-for-patients-with-copd-in-primary-care-a-systematic-review
#11
REVIEW
Elizabeth Baker, Francis Fatoye
BACKGROUND AND OBJECTIVE: Chronic obstructive pulmonary disease is increasing in prevalence and constitutes a major cause of morbidity and mortality globally. As well as contributing to a significant decline in health status in many patients, this condition creates a considerable burden on healthcare providers. Self-management interventions are frequently implemented in community settings to limit the impact of chronic obstructive pulmonary disease on everyday life of individuals and to manage pressure on health systems...
June 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28376639/the-effect-of-symptom-controlling-medication-on-gait-outcomes-in-people-with-multiple-sclerosis-a-systematic-review
#12
Kate Behm, Prue Morgan
PURPOSE: To synthesise and critically appraise randomised controlled trials examining the effect of symptom-controlling medication on gait outcomes in people with multiple sclerosis (MS). METHOD: The literature search examined five databases (Medline, Embase, AMED, Cochrane (CENTRAL), and CINAHL until the end of November 2016. Eligible studies included medication to address symptoms associated with MS and an objective gait outcome measure. Two reviewers independently extracted data and assessed study quality using structured data extraction forms and the PEDro scale...
April 4, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28331826/pulmonary-ground-glass-opacity-computed-tomography-features-histopathology-and-molecular-pathology
#13
REVIEW
Jian-Wei Gao, Stefania Rizzo, Li-Hong Ma, Xiang-Yu Qiu, Arne Warth, Nobuhiko Seki, Mizue Hasegawa, Jia-Wei Zou, Qian Li, Marco Femia, Tang-Feng Lv, Yong Song
The incidence of pulmonary ground-glass opacity (GGO) lesions is increasing as a result of the widespread use of multislice spiral computed tomography (CT) and the low-dose CT screening for lung cancer detection. Besides benign lesions, GGOs can be a specific type of lung adenocarcinomas or their preinvasive lesions. Evaluation of pulmonary GGO and investigation of the correlation between CT imaging features and lung adenocarcinoma subtypes or driver genes can be helpful in confirming the diagnosis and in guiding the clinical management...
February 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28331821/comparison-between-endobronchial-ultrasound-guided-transbronchial-biopsy-and-ct-guided-transthoracic-lung-biopsy-for-the-diagnosis-of-peripheral-lung-cancer-a-systematic-review-and-meta-analysis
#14
Ping Zhan, Qing-Qing Zhu, Ying-Ying Miu, Ya-Fang Liu, Xiao-Xia Wang, Ze-Jun Zhou, Jia-Jia Jin, Qian Li, Shinji Sasada, Takehiro Izumo, Chih-Yen Tu, Wen-Chien Cheng, Matthew Evison, Tang-Feng Lv, Yong Song
BACKGROUND: With the release of the National Lung Screening Trial results, the detection of peripheral pulmonary lesions (PPLs) is likely to increase. Computed tomography (CT)-guided percutaneous transthoracic needle biopsy (PTNB) and radial probe endobronchial ultrasound (r-EBUS)-guided transbronchial lung biopsy (TBLB) are recommended for tissue diagnosis of PPLs. METHODS: A systematic review of published literature evaluating the accuracy of r-EBUS-TBLB and CT-PTNB for the diagnosis of PPLs was performed to determine point sensitivity and specificity, and to construct a summary receiver-operating characteristic curve...
February 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28237770/the-reliability-of-physical-examination-tests-for-the-clinical-assessment-of-scapular-dyskinesis-in-subjects-with-shoulder-complaints-a-systematic-review
#15
REVIEW
Toni Lange, Filip Struyf, Jochen Schmitt, Jörg Lützner, Christian Kopkow
STUDY DESIGN: Systematic review. OBJECTIVES: The aim of this systematic review was to summarize and evaluate intra- and interrater reliability research of physical examination tests used for the assessment of scapular dyskinesis. BACKGROUND: Scapular dyskinesis, defined as alteration of normal scapular kinematics, is described as a non-specific response to different shoulder pathologies. METHODS: A systematic literature search was conducted in MEDLINE, EMBASE, AMED and PEDro until March 20th, 2015...
November 3, 2016: Physical Therapy in Sport
https://www.readbyqxmd.com/read/28223305/eighty-three-per-cent-of-elite-athletes-return-to-preinjury-sport-after-anterior-cruciate-ligament-reconstruction-a-systematic-review-with-meta-analysis-of-return-to-sport-rates-graft-rupture-rates-and-performance-outcomes
#16
REVIEW
Courtney C H Lai, Clare L Ardern, Julian A Feller, Kate E Webster
OBJECTIVES: The primary objective was to calculate the rate of return to sport (RTS) following anterior cruciate ligament (ACL) reconstruction in elite athletes. Secondary objectives were to estimate the time taken to RTS, calculate rates of ACL graft rupture, evaluate postsurgical athletic performance and identify determinants of RTS. DESIGN: Pooled RTS and graft rupture rates were calculated using random effects proportion meta-analysis. Time to RTS, performance data and determinants of RTS were synthesised descriptively...
February 21, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28191040/moisturisers-for-the-treatment-of-foot-xerosis-a-systematic-review
#17
REVIEW
Justin Parker, Rolf Scharfbillig, Sara Jones
BACKGROUND: Xerosis, literally dryness of the skin, of the foot is a common condition encountered clinically, which can lead to discomfort and predisposition to infection. Currently, there are no evidence-based recommendations on which moisturiser formulations best alleviate xerotic symptoms. The aim of this review was to guide clinical practice in the treatment of primary and diabetes related foot xerosis, by identifying from the existing literature the most effective ingredient or formulation of topical treatments for symptoms of primary foot xerosis in the general population...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/28139408/british-columbian-healthcare-providers-perspectives-on-facilitators-and-barriers-to-adhering-to-pediatric-diabetes-treatment-guidelines
#18
Bonnie McIntosh, Karine Khatchadourian, Shazhan Amed
OBJECTIVES: There are few studies exploring why adherence to clinical practice guidelines for the treatment of childhood type 1 diabetes is suboptimal. Our objective was to describe healthcare providers' perspectives on the facilitators of and barriers to adhering to pediatric diabetes treatment guidelines. METHODS: We fielded an electronic survey to 260 pediatric diabetes healthcare providers (physicians, nurses, dietitians) in British Columbia, Canada, followed by qualitative interviews with a purposeful sample (N=15) of physicians and allied healthcare providers...
April 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28047420/su-f-j-57-effectiveness-of-daily-ct-based-three-dimensional-image-guided-and-adaptive-proton-therapy
#19
S Moriya, H Tachibana, K Hotta, N Nakamura, H Baba, R Kohno, S Miyakawa, T Kurosawa, T Akimoto
PURPOSE: Daily CT-based three-dimensional image-guided and adaptive (CTIGRT-ART) proton therapy system was designed and developed. We also evaluated the effectiveness of the CTIGRT-ART. METHODS: Retrospective analysis was performed in three lung cancer patients: Proton treatment planning was performed using CT image datasets acquired by Toshiba Aquilion ONE. Planning target volume and surrounding organs were contoured by a well-trained radiation oncologist. Dose distribution was optimized using 180-deg...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27965837/optimisation-of-complex-health-interventions-prior-to-a-randomised-controlled-trial-a-scoping-review-of-strategies-used
#20
REVIEW
Sara Levati, Pauline Campbell, Rachael Frost, Nadine Dougall, Mary Wells, Cam Donaldson, Suzanne Hagen
BACKGROUND: Many complex intervention trials fail to show an intervention effect. Although this may be due to genuine ineffectiveness, it may also be the result of sub-optimal intervention design, implementation failure or a combination of these. Given current financial constraints and the pressure to reduce waste and increase value in health services research, pre-trial strategies are needed to reduce the likelihood of design or implementation failure and to maximise the intervention's potential for effectiveness...
2016: Pilot and Feasibility Studies
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