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https://www.readbyqxmd.com/read/28549899/utility-of-published-dna-reactivity-alerts
#1
Alun Myden, Sebastien Guesne, Alex Cayley, Richard V Williams
The identification of impurities with mutagenic potential is required for any potential pharmaceutical. The ICH M7 guidelines state that two complementary in silico toxicity prediction tools may be used to predict the mutagenic potential of pharmaceutical impurities. An expert review of the resulting in silico predictions is required, and numerous publications have been released to guide the expert review process. One such publication suggests that literature-based structural alerts (LBSAs) may provide a suitable aid in the expert review process...
May 23, 2017: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/28537752/imaging-features-of-spindle-cell-breast-lesions
#2
Andrew S Taliaferro, Valerie Fein-Zachary, Shambhavi Venkataraman, Tejas S Mehta, Amee Patel, Priscilla J Slanetz
OBJECTIVE: The purpose of our study is to review the clinical presentation, multimodality appearance, and management of the most common benign and malignant spindle cell lesions of the breast. CONCLUSION: Spindle cell lesions of the breast exhibit characteristic features at mammography, ultrasound, and MRI. Although a definitive diagnosis of these lesions cannot be made with diagnostic imaging alone, knowledge of their characteristic imaging features can assist in refining the differential diagnosis and guiding appropriate management...
May 24, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28438226/n-of-1-trials-and-the-optimal-individualisation-of-drug-treatments-a-systematic-review-protocol
#3
Weyinmi A Demeyin, Julia Frost, Obioha C Ukoumunne, Simon Briscoe, Nicky Britten
BACKGROUND: Guidelines and evidence-based drug treatment recommendations are usually based on the results of clinical trials, which have limited generalisability in routine clinical settings due to their restrictive eligibility criteria. These trials are also conducted in ideal and rigorously controlled settings. N of 1 trials, which are single patient multiple crossover studies, offer a means of increasing the evidence base and individualising care for individuals in clinical practice...
April 24, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28409089/comparative-effectiveness-of-guided-weight-loss-and-physical-activity-monitoring-for-weight-loss-and-metabolic-risks-a-pilot-study
#4
Karissa L Peyer, Laura D Ellingson, Kathryn Bus, Sarah A Walsh, Warren D Franke, Gregory J Welk
Many consumer-based physical activity monitors (PAMs) are available but it is not clear how to use them to most effectively promote weight loss. The purpose of this pilot study was to compare the effectiveness of a personal PAM, a guided weight loss program (GWL), and the combination of these approaches on weight loss and metabolic risk. Participants completed the study in two cohorts: Fall 2010 and Spring 2011. A sample of 72 obese individuals in the Ames, IA area were randomized to one of 3 conditions: 1) (GWL, N = 31), 2) PAM, N = 29, or 3) a combination group (PAM + GWL, N = 29)...
June 2017: Preventive Medicine Reports
https://www.readbyqxmd.com/read/28399427/clinical-and-cost-effectiveness-of-nurse-led-self-management-interventions-for-patients-with-copd-in-primary-care-a-systematic-review
#5
REVIEW
Elizabeth Baker, Francis Fatoye
BACKGROUND AND OBJECTIVE: Chronic obstructive pulmonary disease is increasing in prevalence and constitutes a major cause of morbidity and mortality globally. As well as contributing to a significant decline in health status in many patients, this condition creates a considerable burden on healthcare providers. Self-management interventions are frequently implemented in community settings to limit the impact of chronic obstructive pulmonary disease on everyday life of individuals and to manage pressure on health systems...
March 31, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/28376639/the-effect-of-symptom-controlling-medication-on-gait-outcomes-in-people-with-multiple-sclerosis-a-systematic-review
#6
Kate Behm, Prue Morgan
PURPOSE: To synthesise and critically appraise randomised controlled trials examining the effect of symptom-controlling medication on gait outcomes in people with multiple sclerosis (MS). METHOD: The literature search examined five databases (Medline, Embase, AMED, Cochrane (CENTRAL), and CINAHL until the end of November 2016. Eligible studies included medication to address symptoms associated with MS and an objective gait outcome measure. Two reviewers independently extracted data and assessed study quality using structured data extraction forms and the PEDro scale...
April 4, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28331826/pulmonary-ground-glass-opacity-computed-tomography-features-histopathology-and-molecular-pathology
#7
REVIEW
Jian-Wei Gao, Stefania Rizzo, Li-Hong Ma, Xiang-Yu Qiu, Arne Warth, Nobuhiko Seki, Mizue Hasegawa, Jia-Wei Zou, Qian Li, Marco Femia, Tang-Feng Lv, Yong Song
The incidence of pulmonary ground-glass opacity (GGO) lesions is increasing as a result of the widespread use of multislice spiral computed tomography (CT) and the low-dose CT screening for lung cancer detection. Besides benign lesions, GGOs can be a specific type of lung adenocarcinomas or their preinvasive lesions. Evaluation of pulmonary GGO and investigation of the correlation between CT imaging features and lung adenocarcinoma subtypes or driver genes can be helpful in confirming the diagnosis and in guiding the clinical management...
February 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28331821/comparison-between-endobronchial-ultrasound-guided-transbronchial-biopsy-and-ct-guided-transthoracic-lung-biopsy-for-the-diagnosis-of-peripheral-lung-cancer-a-systematic-review-and-meta-analysis
#8
Ping Zhan, Qing-Qing Zhu, Ying-Ying Miu, Ya-Fang Liu, Xiao-Xia Wang, Ze-Jun Zhou, Jia-Jia Jin, Qian Li, Shinji Sasada, Takehiro Izumo, Chih-Yen Tu, Wen-Chien Cheng, Matthew Evison, Tang-Feng Lv, Yong Song
BACKGROUND: With the release of the National Lung Screening Trial results, the detection of peripheral pulmonary lesions (PPLs) is likely to increase. Computed tomography (CT)-guided percutaneous transthoracic needle biopsy (PTNB) and radial probe endobronchial ultrasound (r-EBUS)-guided transbronchial lung biopsy (TBLB) are recommended for tissue diagnosis of PPLs. METHODS: A systematic review of published literature evaluating the accuracy of r-EBUS-TBLB and CT-PTNB for the diagnosis of PPLs was performed to determine point sensitivity and specificity, and to construct a summary receiver-operating characteristic curve...
February 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28237770/the-reliability-of-physical-examination-tests-for-the-clinical-assessment-of-scapular-dyskinesis-in-subjects-with-shoulder-complaints-a-systematic-review
#9
REVIEW
Toni Lange, Filip Struyf, Jochen Schmitt, Jörg Lützner, Christian Kopkow
STUDY DESIGN: Systematic review. OBJECTIVES: The aim of this systematic review was to summarize and evaluate intra- and interrater reliability research of physical examination tests used for the assessment of scapular dyskinesis. BACKGROUND: Scapular dyskinesis, defined as alteration of normal scapular kinematics, is described as a non-specific response to different shoulder pathologies. METHODS: A systematic literature search was conducted in MEDLINE, EMBASE, AMED and PEDro until March 20th, 2015...
November 3, 2016: Physical Therapy in Sport
https://www.readbyqxmd.com/read/28223305/eighty-three-per-cent-of-elite-athletes-return-to-preinjury-sport-after-anterior-cruciate-ligament-reconstruction-a-systematic-review-with-meta-analysis-of-return-to-sport-rates-graft-rupture-rates-and-performance-outcomes
#10
REVIEW
Courtney C H Lai, Clare L Ardern, Julian A Feller, Kate E Webster
OBJECTIVES: The primary objective was to calculate the rate of return to sport (RTS) following anterior cruciate ligament (ACL) reconstruction in elite athletes. Secondary objectives were to estimate the time taken to RTS, calculate rates of ACL graft rupture, evaluate postsurgical athletic performance and identify determinants of RTS. DESIGN: Pooled RTS and graft rupture rates were calculated using random effects proportion meta-analysis. Time to RTS, performance data and determinants of RTS were synthesised descriptively...
February 21, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28191040/moisturisers-for-the-treatment-of-foot-xerosis-a-systematic-review
#11
REVIEW
Justin Parker, Rolf Scharfbillig, Sara Jones
BACKGROUND: Xerosis, literally dryness of the skin, of the foot is a common condition encountered clinically, which can lead to discomfort and predisposition to infection. Currently, there are no evidence-based recommendations on which moisturiser formulations best alleviate xerotic symptoms. The aim of this review was to guide clinical practice in the treatment of primary and diabetes related foot xerosis, by identifying from the existing literature the most effective ingredient or formulation of topical treatments for symptoms of primary foot xerosis in the general population...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/28139408/british-columbian-healthcare-providers-perspectives-on-facilitators-and-barriers-to-adhering-to-pediatric-diabetes-treatment-guidelines
#12
Bonnie McIntosh, Karine Khatchadourian, Shazhan Amed
OBJECTIVES: There are few studies exploring why adherence to clinical practice guidelines for the treatment of childhood type 1 diabetes is suboptimal. Our objective was to describe healthcare providers' perspectives on the facilitators of and barriers to adhering to pediatric diabetes treatment guidelines. METHODS: We fielded an electronic survey to 260 pediatric diabetes healthcare providers (physicians, nurses, dietitians) in British Columbia, Canada, followed by qualitative interviews with a purposeful sample (N=15) of physicians and allied healthcare providers...
January 27, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28047420/su-f-j-57-effectiveness-of-daily-ct-based-three-dimensional-image-guided-and-adaptive-proton-therapy
#13
S Moriya, H Tachibana, K Hotta, N Nakamura, H Baba, R Kohno, S Miyakawa, T Kurosawa, T Akimoto
PURPOSE: Daily CT-based three-dimensional image-guided and adaptive (CTIGRT-ART) proton therapy system was designed and developed. We also evaluated the effectiveness of the CTIGRT-ART. METHODS: Retrospective analysis was performed in three lung cancer patients: Proton treatment planning was performed using CT image datasets acquired by Toshiba Aquilion ONE. Planning target volume and surrounding organs were contoured by a well-trained radiation oncologist. Dose distribution was optimized using 180-deg...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27965837/optimisation-of-complex-health-interventions-prior-to-a-randomised-controlled-trial-a-scoping-review-of-strategies-used
#14
REVIEW
Sara Levati, Pauline Campbell, Rachael Frost, Nadine Dougall, Mary Wells, Cam Donaldson, Suzanne Hagen
BACKGROUND: Many complex intervention trials fail to show an intervention effect. Although this may be due to genuine ineffectiveness, it may also be the result of sub-optimal intervention design, implementation failure or a combination of these. Given current financial constraints and the pressure to reduce waste and increase value in health services research, pre-trial strategies are needed to reduce the likelihood of design or implementation failure and to maximise the intervention's potential for effectiveness...
2016: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/27936603/quantitative-trait-loci-qtl-guided-metabolic-engineering-of-a-complex-trait
#15
Matthew J Maurer, Lawrence Sutardja, Dominic Pinel, Stefan Bauer, Amanda L Muehlbauer, Tyler D Ames, Jeffrey M Skerker, Adam P Arkin
Engineering complex phenotypes for industrial and synthetic biology applications is difficult and often confounds rational design. Bioethanol production from lignocellulosic feedstocks is a complex trait that requires multiple host systems to utilize, detoxify, and metabolize a mixture of sugars and inhibitors present in plant hydrolysates. Here, we demonstrate an integrated approach to discovering and optimizing host factors that impact fitness of Saccharomyces cerevisiae during fermentation of a Miscanthus x giganteus plant hydrolysate...
December 28, 2016: ACS Synthetic Biology
https://www.readbyqxmd.com/read/27927522/adult-spinal-deformity-epidemiology-health-impact-evaluation-and-management
#16
Christopher P Ames, Justin K Scheer, Virginie Lafage, Justin S Smith, Shay Bess, Sigurd H Berven, Gregory M Mundis, Rajiv K Sethi, Donald A Deinlein, Jeffrey D Coe, Lloyd A Hey, Michael D Daubs
Spinal deformity in the adult is a common medical disorder with a significant and measurable impact on health-related quality of life. The ability to measure and quantify patient self-reported health status with disease-specific and general health status measures, and to correlate health status with radiographic and clinical measures of spinal deformity, has enabled significant advances in the assessment of the impact of deformity on our population, and in the evaluation and management of spinal deformity using an evidence-based approach...
July 2016: Spine Deformity
https://www.readbyqxmd.com/read/27852144/appreciative-inquiry-in-medical-education
#17
John Sandars, Deborah Murdoch-Eaton
The practice of medicine, and also medical education, typically adopts a problem-solving approach to identify "what is going wrong" with a situation. However, an alternative is Appreciative Inquiry (AI), which adopts a positive and strengths-based approach to identify "what is going well" with a situation. The AI approach can be used for the development and enhancement of the potential of both individuals and organizations. An essential aspect of the AI approach is the generative process, in which a new situation is envisioned and both individual and collective strengths are mobilized to make changes to achieve the valued future situation...
February 2017: Medical Teacher
https://www.readbyqxmd.com/read/27834675/conservative-treatments-for-greater-trochanteric-pain-syndrome-a-systematic-review
#18
REVIEW
Paul A Barratt, Nathan Brookes, Annalisa Newson
BACKGROUND: Greater trochanteric pain syndrome (GTPS) can have a significant effect on quality of life. AIM: To evaluate the conservative treatments for GTPS. DESIGN: This systematic review assessed risk of bias using the Cochrane Risk of Bias Tool and Cochrane Risk of Bias Tool for non-randomised studies of interventions. DATA SOURCES: On 13 January 2016, a comprehensive search was conducted, with no limit on year of publication for relevant studies in the MEDLINE, CINAHL, AMED and EMBASE databases...
January 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27816862/the-utility-and-impact-of-information-communication-technology-ict-for-pre-registration-nurse-education-a-narrative-synthesis-systematic-review
#19
REVIEW
Lucy Webb, Jonathan Clough, Declan O'Reilly, Danita Wilmott, Gary Witham
OBJECTIVES: To evaluate and summarise the utility and impact of information communication technology (ICT) in enhancing student performance and the learning environment in pre-registration nursing. DESIGN: A systematic review of empirical research across a range of themes in ICT health-related education. DATA SOURCES: Science Direct, Cinahl, AMED, MEDLINE, PubMed, ASSIA, OVID and OVID SP (2008-2014). Further date parameters were imposed by theme...
January 2017: Nurse Education Today
https://www.readbyqxmd.com/read/27774351/impact-of-a-10-minute-seated-yoga-practice-in-the-management-of-diabetes
#20
Rashmi S Mullur, Donna Ames
OBJECTIVE: We sought to prospectively evaluate the impact of a 10 minute seated yoga program added to standard comprehensive diabetes care on glucose control and cardiovascular health in the severely ill, medically complex diabetic population. METHOD: A total of 10 patients with type 2 diabetes, ages 49-77, with duration of diabetes >10 years and haemoglobin A1C >9% (75 mmol/mol) were included in the study. Patients randomized to a yoga intervention were taught a 10 minute seated yoga practice, were given an explanatory DVD and a fold-out pocket guide to encourage adherence at home, and were instructed to incorporate the practice as often as they could...
January 18, 2016: Journal of Yoga & Physical Therapy
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