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AMEE Guide

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https://www.readbyqxmd.com/read/28331826/pulmonary-ground-glass-opacity-computed-tomography-features-histopathology-and-molecular-pathology
#1
REVIEW
Jian-Wei Gao, Stefania Rizzo, Li-Hong Ma, Xiang-Yu Qiu, Arne Warth, Nobuhiko Seki, Mizue Hasegawa, Jia-Wei Zou, Qian Li, Marco Femia, Tang-Feng Lv, Yong Song
The incidence of pulmonary ground-glass opacity (GGO) lesions is increasing as a result of the widespread use of multislice spiral computed tomography (CT) and the low-dose CT screening for lung cancer detection. Besides benign lesions, GGOs can be a specific type of lung adenocarcinomas or their preinvasive lesions. Evaluation of pulmonary GGO and investigation of the correlation between CT imaging features and lung adenocarcinoma subtypes or driver genes can be helpful in confirming the diagnosis and in guiding the clinical management...
February 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28331821/comparison-between-endobronchial-ultrasound-guided-transbronchial-biopsy-and-ct-guided-transthoracic-lung-biopsy-for-the-diagnosis-of-peripheral-lung-cancer-a-systematic-review-and-meta-analysis
#2
Ping Zhan, Qing-Qing Zhu, Ying-Ying Miu, Ya-Fang Liu, Xiao-Xia Wang, Ze-Jun Zhou, Jia-Jia Jin, Qian Li, Shinji Sasada, Takehiro Izumo, Chih-Yen Tu, Wen-Chien Cheng, Matthew Evison, Tang-Feng Lv, Yong Song
BACKGROUND: With the release of the National Lung Screening Trial results, the detection of peripheral pulmonary lesions (PPLs) is likely to increase. Computed tomography (CT)-guided percutaneous transthoracic needle biopsy (PTNB) and radial probe endobronchial ultrasound (r-EBUS)-guided transbronchial lung biopsy (TBLB) are recommended for tissue diagnosis of PPLs. METHODS: A systematic review of published literature evaluating the accuracy of r-EBUS-TBLB and CT-PTNB for the diagnosis of PPLs was performed to determine point sensitivity and specificity, and to construct a summary receiver-operating characteristic curve...
February 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/28237770/the-reliability-of-physical-examination-tests-for-the-clinical-assessment-of-scapular-dyskinesis-in-subjects-with-shoulder-complaints-a-systematic-review
#3
REVIEW
Toni Lange, Filip Struyf, Jochen Schmitt, Jörg Lützner, Christian Kopkow
STUDY DESIGN: Systematic review. OBJECTIVES: The aim of this systematic review was to summarize and evaluate intra- and interrater reliability research of physical examination tests used for the assessment of scapular dyskinesis. BACKGROUND: Scapular dyskinesis, defined as alteration of normal scapular kinematics, is described as a non-specific response to different shoulder pathologies. METHODS: A systematic literature search was conducted in MEDLINE, EMBASE, AMED and PEDro until March 20th, 2015...
November 3, 2016: Physical Therapy in Sport
https://www.readbyqxmd.com/read/28223305/eighty-three-per-cent-of-elite-athletes-return-to-preinjury-sport-after-anterior-cruciate-ligament-reconstruction-a-systematic-review-with-meta-analysis-of-return-to-sport-rates-graft-rupture-rates-and-performance-outcomes
#4
REVIEW
Courtney C H Lai, Clare L Ardern, Julian A Feller, Kate E Webster
OBJECTIVES: The primary objective was to calculate the rate of return to sport (RTS) following anterior cruciate ligament (ACL) reconstruction in elite athletes. Secondary objectives were to estimate the time taken to RTS, calculate rates of ACL graft rupture, evaluate postsurgical athletic performance and identify determinants of RTS. DESIGN: Pooled RTS and graft rupture rates were calculated using random effects proportion meta-analysis. Time to RTS, performance data and determinants of RTS were synthesised descriptively...
February 21, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28191040/moisturisers-for-the-treatment-of-foot-xerosis-a-systematic-review
#5
REVIEW
Justin Parker, Rolf Scharfbillig, Sara Jones
BACKGROUND: Xerosis, literally dryness of the skin, of the foot is a common condition encountered clinically, which can lead to discomfort and predisposition to infection. Currently, there are no evidence-based recommendations on which moisturiser formulations best alleviate xerotic symptoms. The aim of this review was to guide clinical practice in the treatment of primary and diabetes related foot xerosis, by identifying from the existing literature the most effective ingredient or formulation of topical treatments for symptoms of primary foot xerosis in the general population...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/28139408/british-columbian-healthcare-providers-perspectives-on-facilitators-and-barriers-to-adhering-to-pediatric-diabetes-treatment-guidelines
#6
Bonnie McIntosh, Karine Khatchadourian, Shazhan Amed
OBJECTIVES: There are few studies exploring why adherence to clinical practice guidelines for the treatment of childhood type 1 diabetes is suboptimal. Our objective was to describe healthcare providers' perspectives on the facilitators of and barriers to adhering to pediatric diabetes treatment guidelines. METHODS: We fielded an electronic survey to 260 pediatric diabetes healthcare providers (physicians, nurses, dietitians) in British Columbia, Canada, followed by qualitative interviews with a purposeful sample (N=15) of physicians and allied healthcare providers...
January 27, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/28047420/su-f-j-57-effectiveness-of-daily-ct-based-three-dimensional-image-guided-and-adaptive-proton-therapy
#7
S Moriya, H Tachibana, K Hotta, N Nakamura, H Baba, R Kohno, S Miyakawa, T Kurosawa, T Akimoto
PURPOSE: Daily CT-based three-dimensional image-guided and adaptive (CTIGRT-ART) proton therapy system was designed and developed. We also evaluated the effectiveness of the CTIGRT-ART. METHODS: Retrospective analysis was performed in three lung cancer patients: Proton treatment planning was performed using CT image datasets acquired by Toshiba Aquilion ONE. Planning target volume and surrounding organs were contoured by a well-trained radiation oncologist. Dose distribution was optimized using 180-deg...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/27965837/optimisation-of-complex-health-interventions-prior-to-a-randomised-controlled-trial-a-scoping-review-of-strategies-used
#8
REVIEW
Sara Levati, Pauline Campbell, Rachael Frost, Nadine Dougall, Mary Wells, Cam Donaldson, Suzanne Hagen
BACKGROUND: Many complex intervention trials fail to show an intervention effect. Although this may be due to genuine ineffectiveness, it may also be the result of sub-optimal intervention design, implementation failure or a combination of these. Given current financial constraints and the pressure to reduce waste and increase value in health services research, pre-trial strategies are needed to reduce the likelihood of design or implementation failure and to maximise the intervention's potential for effectiveness...
2016: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/27936603/quantitative-trait-loci-qtl-guided-metabolic-engineering-of-a-complex-trait
#9
Matthew J Maurer, Lawrence Sutardja, Dominic Pinel, Stefan Bauer, Amanda L Muehlbauer, Tyler D Ames, Jeffrey M Skerker, Adam P Arkin
Engineering complex phenotypes for industrial and synthetic biology applications is difficult and often confounds rational design. Bioethanol production from lignocellulosic feedstocks is a complex trait that requires multiple host systems to utilize, detoxify, and metabolize a mixture of sugars and inhibitors present in plant hydrolysates. Here, we demonstrate an integrated approach to discovering and optimizing host factors that impact fitness of Saccharomyces cerevisiae during fermentation of a Miscanthus x giganteus plant hydrolysate...
December 28, 2016: ACS Synthetic Biology
https://www.readbyqxmd.com/read/27927522/adult-spinal-deformity-epidemiology-health-impact-evaluation-and-management
#10
Christopher P Ames, Justin K Scheer, Virginie Lafage, Justin S Smith, Shay Bess, Sigurd H Berven, Gregory M Mundis, Rajiv K Sethi, Donald A Deinlein, Jeffrey D Coe, Lloyd A Hey, Michael D Daubs
Spinal deformity in the adult is a common medical disorder with a significant and measurable impact on health-related quality of life. The ability to measure and quantify patient self-reported health status with disease-specific and general health status measures, and to correlate health status with radiographic and clinical measures of spinal deformity, has enabled significant advances in the assessment of the impact of deformity on our population, and in the evaluation and management of spinal deformity using an evidence-based approach...
July 2016: Spine Deformity
https://www.readbyqxmd.com/read/27852144/appreciative-inquiry-in-medical-education
#11
John Sandars, Deborah Murdoch-Eaton
The practice of medicine, and also medical education, typically adopts a problem-solving approach to identify "what is going wrong" with a situation. However, an alternative is Appreciative Inquiry (AI), which adopts a positive and strengths-based approach to identify "what is going well" with a situation. The AI approach can be used for the development and enhancement of the potential of both individuals and organizations. An essential aspect of the AI approach is the generative process, in which a new situation is envisioned and both individual and collective strengths are mobilized to make changes to achieve the valued future situation...
February 2017: Medical Teacher
https://www.readbyqxmd.com/read/27834675/conservative-treatments-for-greater-trochanteric-pain-syndrome-a-systematic-review
#12
Paul A Barratt, Nathan Brookes, Annalisa Newson
BACKGROUND: Greater trochanteric pain syndrome (GTPS) can have a significant effect on quality of life. AIM: To evaluate the conservative treatments for GTPS. DESIGN: This systematic review assessed risk of bias using the Cochrane Risk of Bias Tool and Cochrane Risk of Bias Tool for non-randomised studies of interventions. DATA SOURCES: On 13 January 2016, a comprehensive search was conducted, with no limit on year of publication for relevant studies in the MEDLINE, CINAHL, AMED and EMBASE databases...
January 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27816862/the-utility-and-impact-of-information-communication-technology-ict-for-pre-registration-nurse-education-a-narrative-synthesis-systematic-review
#13
REVIEW
Lucy Webb, Jonathan Clough, Declan O'Reilly, Danita Wilmott, Gary Witham
OBJECTIVES: To evaluate and summarise the utility and impact of information communication technology (ICT) in enhancing student performance and the learning environment in pre-registration nursing. DESIGN: A systematic review of empirical research across a range of themes in ICT health-related education. DATA SOURCES: Science Direct, Cinahl, AMED, MEDLINE, PubMed, ASSIA, OVID and OVID SP (2008-2014). Further date parameters were imposed by theme...
January 2017: Nurse Education Today
https://www.readbyqxmd.com/read/27774351/impact-of-a-10-minute-seated-yoga-practice-in-the-management-of-diabetes
#14
Rashmi S Mullur, Donna Ames
OBJECTIVE: We sought to prospectively evaluate the impact of a 10 minute seated yoga program added to standard comprehensive diabetes care on glucose control and cardiovascular health in the severely ill, medically complex diabetic population. METHOD: A total of 10 patients with type 2 diabetes, ages 49-77, with duration of diabetes >10 years and haemoglobin A1C >9% (75 mmol/mol) were included in the study. Patients randomized to a yoga intervention were taught a 10 minute seated yoga practice, were given an explanatory DVD and a fold-out pocket guide to encourage adherence at home, and were instructed to incorporate the practice as often as they could...
January 18, 2016: Journal of Yoga & Physical Therapy
https://www.readbyqxmd.com/read/27773722/prediction-of-pharmacokinetic-and-toxicological-parameters-of-a-4-phenylcoumarin-isolated-from-geopropolis-in-silico-and-in-vitro-approaches
#15
Marcos Guilherme da Cunha, Gilson César Nobre Franco, Marcelo Franchin, John A Beutler, Severino Matias de Alencar, Masaharu Ikegaki, Pedro Luiz Rosalen
In silico and in vitro methodologies have been used as important tools in the drug discovery process, including from natural sources. The aim of this study was to predict pharmacokinetic and toxicity (ADME/Tox) properties of a coumarin isolated from geopropolis using in silico and in vitro approaches. Cinnamoyloxy-mammeisin (CNM) isolated from Brazilian M. scutellaris geopropolis was evaluated for its pharmacokinetic parameters by in silico models (ACD/Percepta™ and MetaDrug™ software). Genotoxicity was assessed by in vitro DNA damage signaling PCR array...
November 30, 2016: Toxicology Letters
https://www.readbyqxmd.com/read/27608933/producing-a-socially-accountable-medical-school-amee-guide-no-109
#16
Charles Boelen, David Pearson, Arthur Kaufman, James Rourke, Robert Woollard, David C Marsh, Trevor Gibbs
Health systems worldwide are confronted with challenges due to increased demand from their citizens, an aging population, a variety of health risks and limited resources. Key health stakeholders, including academic institutions and medical schools, are urged to develop a common vision for a more efficient and equitable health sector. It is in this environment that Boelen and Heck defined the concept of the "Social Accountability of Medical Schools" - a concept that encourages schools to produce not just highly competent professionals, but professionals who are equipped to respond to the changing challenges of healthcare through re-orientation of their education, research and service commitments, and be capable of demonstrating a positive effect upon the communities they serve...
November 2016: Medical Teacher
https://www.readbyqxmd.com/read/27605692/reversible-intraoperative-neurophysiologic-monitoring-alerts-in-patients-undergoing-arthrodesis-for-adolescent-idiopathic-scoliosis-what-are-the-outcomes-of-surgery
#17
Amer F Samdani, James T Bennett, Robert J Ames, Jahangir K Asghar, Giuseppe Orlando, Joshua M Pahys, Burt Yaszay, Firoz Miyanji, Baron S Lonner, Ronald A Lehman, Peter O Newton, Patrick J Cahill, Randal R Betz
BACKGROUND: Confidence in intraoperative neurophysiologic monitoring (IONM) data can allow scoliosis surgeons to proceed with surgery even after a monitoring alert, assuming the recovery of signals. We sought to determine the outcomes of surgical treatment of adolescent idiopathic scoliosis (AIS) after a notable IONM alert. METHODS: We identified 676 patients who underwent arthrodesis with use of IONM for the treatment of AIS. The patients were divided into 2 cohorts: those who experienced a lower-extremity IONM alert and those who did not...
September 7, 2016: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/27597323/writing-competitive-research-conference-abstracts-amee-guide-no-108
#18
Lara Varpio, Jonathan Amiel, Boyd F Richards
The ability to write a competitive research conference abstract is an important skill for medical educators. A compelling and concise abstract can convince peer reviewers, conference selection committee members, and conference attendees that the research described therein is worthy for inclusion in the conference program and/or for their attendance in the meeting. This AMEE Guide is designed to help medical educators write research conference abstracts that can achieve these outcomes. To do so, this Guide begins by examining the rhetorical context (i...
September 2016: Medical Teacher
https://www.readbyqxmd.com/read/27482609/italian-association-of-clinical-endocrinologists-statement-replacement-therapy-for-primary-hypothyroidism-a-brief-guide-for-clinical-practice
#19
Rinaldo Guglielmi, Andrea Frasoldati, Michele Zini, Franco Grimaldi, Hossein Gharib, Jeffrey R Garber, Enrico Papini
OBJECTIVE: Hypothyroidism requires life-long thyroid hormone replacement therapy in most patients. Oral levothyroxine (LT4) is an established safe and effective treatment for hypothyroidism, but some issues remain unsettled. METHODS: The Italian Association of Clinical Endocrinologists appointed a panel of experts to provide an updated statement for appropriate use of thyroid hormone formulations for hypothyroidism replacement therapy. The American Association of Clinical Endocrinologists' protocol for standardized production of clinical practice guidelines was followed...
November 2016: Endocrine Practice
https://www.readbyqxmd.com/read/27338432/wayfinding-the-live-5-2-1-0-initiative-at-the-intersection-between-systems-thinking-and-community-based-childhood-obesity-prevention
#20
Shazhan Amed, Stephanie Shea, Susan Pinkney, Joan Wharf Higgins, Patti-Jean Naylor
Childhood obesity is complex and requires a 'systems approach' that collectively engages across multiple community settings. Sustainable Childhood Obesity Prevention through Community Engagement (SCOPE) has implemented Live 5-2-1-0-a multi-sector, multi-component childhood obesity prevention initiative informed by systems thinking and participatory research via an innovative knowledge translation (KT) model (RE-FRAME). This paper describes the protocol for implementing and evaluating RE-FRAME in two 'existing' (>2 years of implementation) and two 'new' Live 5-2-1-0 communities to understand how to facilitate and sustain systems/community-level change...
2016: International Journal of Environmental Research and Public Health
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