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https://www.readbyqxmd.com/read/29730133/cytotoxic-effect-of-kalanchoe-flammea-and-induction-of-intrinsic-mitochondrial-apoptotic-signaling-in-prostate-cancer-cells
#1
Iván Arias-González, Alejandro M García-Carrancá, Jorge Cornejo-Garrido, Cynthia Ordaz-Pichardo
Ethnopharmacological importance: Kalanchoe flammea Stapf (Crassulaceae) is a medicinal plant grown in the South of Mexico (State of Tabasco), which is commonly used in traditional medicine for the treatment of fever, wounds, inflammation, and cancer. AIM OF THE STUDY: To establish the potential of K. flammea for the treatment of prostate cancer, evaluating its cytotoxic activity, its probable mechanism of action, and carrying out some toxicological safety studies. MATERIALS AND METHODS: The cytotoxic activity of the ethyl acetate extract of K...
May 3, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29723417/discontinuation-of-tyrosine-kinase-inhibitors-in-chronic-myeloid-leukemia-recommendations-for-clinical-practice-from-the-french-chronic-myeloid-leukemia-study-group
#2
Delphine Rea, Shanti Ame, Marc Berger, Jean-Michel Cayuela, Aude Charbonnier, Valérie Coiteux, Pascale Cony-Makhoul, Viviane Dubruille, Stéphanie Dulucq, Gabriel Etienne, Laurence Legros, Franck Nicolini, Catherine Roche-Lestienne, Martine Escoffre-Barbe, Martine Gardembas, Agnès Guerci-Bresler, Hyacinthe Johnson-Ansah, Françoise Rigal-Huguet, Philippe Rousselot, François-Xavier Mahon
BACKGROUND: The ultimate goal of chronic myeloid leukemia management in the tyrosine kinase inhibitor (TKI) era for patients who obtain deep molecular responses is maintaining a durable off-treatment response after treatment discontinuation; this situation is called treatment-free remission (TFR). Knowledge accumulated during the last 10 years justifies moving TFR strategies from research to clinical practice. METHODS: Twenty experts from the French Chronic Myeloid Leukemia Study Group (France Intergroupe des Leucémies Myéloïdes Chroniques), including 17 hematologists, 2 molecular biologists, and 1 cytogeneticist, critically reviewed published data with the goal of developing evidence-based recommendations for TKI discontinuation in clinical practice...
May 3, 2018: Cancer
https://www.readbyqxmd.com/read/29669089/what-works-and-does-not-work-in-a-self-management-intervention-for-people-with-chronic-pain-qualitative-systematic-review-and-meta-synthesis
#3
Hemakumar Devan, Leigh Hale, Dagmar Hempel, Barbara Saipe, Meredith A Perry
Background: Self-management interventions fostering self-efficacy improve the well-being of people with chronic pain. Purpose: The purpose of this study was to synthesize the enablers (what works) and barriers (what does not) of incorporating self-management strategies for people in everyday life after completion of a pain self-management intervention. Data Sources: Major electronic databases (MEDLINE, AMED, PsycINFO, Cochrane Library, PubMed, CINAHL, Scopus, and Google Scholar) were searched from inception to July 2016...
May 1, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29595668/fennel-foeniculum-vulgare-on-management-of-menopausal-symptoms-a-protocol-for-systematic-review-of-randomized-controlled-trials
#4
Hye Won Lee, Hyun-Ja Lim, Ji Hee Jun, Hyun-Suk Lim, Myeong Soo Lee
BACKGROUND: Fennel (Foeniculum vulgare) is often used in women's health care to treat dysmenorrhea, increase the milk supply, and address symptoms of menopause. The object of this review is to evaluate the current evidence on the efficacy of fennel for the management menopausal symptoms. METHODS AND ANALYSES: Thirteen databases will be searched from their inception to the present. These include PubMed, AMED, EMBASE, the Cochrane Library, six Korean medical databases (Korean Studies Information Service System, DBPIA, the Korean Institute of Science and Technology Information, the Research Information Service System, KoreaMed, and the Korean National Assembly Library), and 3 Chinese databases (the China National Knowledge Infrastructure Database [CNKI], the Chongqing VIP Chinese Science and Technology Periodical Database [VIP], and Wanfang Database)...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29542236/what-form-does-informal-assessment-take-a-scoping-review-of-the-informal-assessment-literature-for-aphasia
#5
REVIEW
Jennifer Thomson, Melanie Gee, Karen Sage, Traci Walker
BACKGROUND: Aphasia assessment is traditionally divided into formal and informal approaches. Informal assessment is useful in developing a rich understanding of the person with aphasia's performance, e.g., describing performance in the context of real-world activities, and exploring the impact of environmental and/or partner supports upon communication. However, defining 'informal assessment' is problematic and can result in clinical issues including idiosyncratic practices regarding why, when and how to apply informal assessment...
March 15, 2018: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29538203/acupuncture-for-the-treatment-of-trigeminal-neuralgia-a-protocol-for-the-systematic-review-of-randomized-controlled-trials
#6
REVIEW
Jong-In Kim, Hee-Jung Kim, Jung Ju Lee, Ji Hee Jun, Tae-Young Choi, Myeong Soo Lee
BACKGROUND: The ability of acupuncture to successfully control pain has been reported in the past. However, currently no systematic reviews exist regarding the effect of acupuncture on trigeminal neuralgia (TN). This proposed review aims to evaluate the current evidence on the efficacy of acupuncture for the management of pain in TN. METHODS: A total of 11 databases were searched from their inception. These include MEDLINE, AMED, EMBASE, the Cochrane Library, 6 Korean medical databases, and 1 Chinese Medical Database...
March 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29506956/investigating-the-effects-of-the-progressive-muscle-relaxation-guided-imagery-combination-on-patients-with-cancer-receiving-chemotherapy-treatment-a-systematic-review-of-randomized-controlled-trials
#7
August Kapogiannis, Sofia Tsoli, George Chrousos
BACKGROUND: Previous systematic reviews indicate that progressive muscle relaxation (PMR) and guided imagery (GI) are both effective interventions to decrease the psychological impact and to alleviate the adverse events in cancer patients undergoing chemotherapy treatment. To date, no review studies have investigated the effectiveness of a combination of PMR and GI. AIM: To systematically review the current state of knowledge regarding the effects of the PMR-GI combination on cancer patients receiving chemotherapy...
March 2018: Explore: the Journal of Science and Healing
https://www.readbyqxmd.com/read/29464356/weighing-the-anti-ischemic-benefits-and-bleeding-risks-from-aspirin-therapy-a-rational-approach
#8
REVIEW
Sagar Dugani, Jeffrey M Ames, JoAnn E Manson, Samia Mora
PURPOSE OF REVIEW: The role of aspirin in secondary cardiovascular prevention is well understood; however, the role in primary prevention is less clear, and requires careful balancing of potential benefits with risks. Here, we summarize the evidence base on the benefits and risks of aspirin therapy, discuss clinical practice guidelines and decision support tools to assist in initiating aspirin therapy, and highlight ongoing trials that may clarify the role of aspirin in cardiovascular disease prevention...
February 21, 2018: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/29419682/acupuncture-for-management-of-lower-urinary-tract-symptoms-in-parkinson-s-disease-a-protocol-for-the-systematic-review-of-randomized-controlled-trials
#9
REVIEW
Jong-In Kim, Tae-Young Choi, Ji Hee Jun, Hee Kang, Myeong Soo Lee
BACKGROUND: Acupuncture is claimed to improve the lower urinary tract symptoms (LUTS). Currently, no systematic reviews are performed for acupuncture on LUTS in patients with Parkinson's diseases (PD). This review aims to evaluate the current evidence on the efficacy of acupuncture for the management of LUTS in PD. METHODS AND ANALYSES: Eleven databases will be searched from their inception. These include PubMed, AMED, EMBASE, the Cochrane Library, 6 Korean medical databases, and 1 Chinese medical database...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29374482/what-is-known-about-pathways-to-mental-health-care-for-australian-aboriginal-young-people-a-narrative-review
#10
REVIEW
Alexandra Kilian, Anna Williamson
OBJECTIVES: To (1) gain an understanding of current trajectories of Aboriginal young people through the mental health care system in Australia; (2) summarize what mental health care pathways have been developed or evaluated to guide mental health care delivery for Aboriginal young people; and (3) identify barriers and facilitators to the adoption of effective mental health care pathways for Aboriginal young people. METHODS: Databases, including, AMED, Embase, Global Health, Health and Psychosocial Instruments, Healthstar, MEDLINE, PsychINFO via Ovid, CINAHL via EBSCO, The Cochrane Library, Indigenous Collections, Informit and Health Systems Evidence, were searched to identify evidence concerning mental health service delivery for Aboriginal young people in a primary care setting...
January 27, 2018: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29286534/fitness-training-for-cardiorespiratory-conditioning-after-traumatic-brain-injury
#11
REVIEW
Leanne Hassett, Anne M Moseley, Alison R Harmer
BACKGROUND: Reduced cardiorespiratory fitness (cardiorespiratory deconditioning) is a common consequence of traumatic brain injury (TBI). Fitness training may be implemented to address this impairment. OBJECTIVES: The primary objective of this updated review was to evaluate whether fitness training improves cardiorespiratory fitness in people who have sustained a TBI. The secondary objectives were to evaluate whether fitness training improves body function and structure (physical and cognitive impairments, psychological responses resulting from the injury), activity limitations and participation restrictions in people who have sustained a TBI as well as to evaluate its safety, acceptance, feasibility and suitability...
December 29, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29202331/using-the-icf-in-transition-research-and-practice-lessons-from-a-scoping-review
#12
REVIEW
Tram Nguyen, Debra Stewart, Peter Rosenbaum, Sue Baptiste, Olaf Kraus de Camargo, Jan Willem Gorter
BACKGROUND: The International Classification of Functioning, Disability and Health (ICF) and subsequent ICF-CY (child and youth version) recognize the importance of personal and environmental factors in facilitating holistic transition planning and service delivery for youth with chronic health conditions (YCHC). AIMS: The objective of this scoping review is to investigate the degree to which the ICF and ICF-CY have been used in transition research and practice since its initial publication...
January 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29157341/glaucoma-in-u-s-civil-aviation-2005-2014
#13
Charles A DeJohn, William D Mills
INTRODUCTION: Until recently, glaucoma requiring treatment was disqualifying for U.S. pilots and required an aeromedical special issuance waiver. Since 2013 Aerospace Medical Examiners (AMEs) have been authorized to evaluate third-class pilots with mild glaucoma using similar protocols and issue medical certificates without a waiver if these criteria specified in the AME Guide are met. METHODS: The FAA's medical database was searched for pilots with glaucoma between 2005 and 2014...
December 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29149142/mapping-the-association-between-vitamin-d-and-low-back-pain-a-systematic-review-and-meta-analysis-of-observational-studies
#14
Joshua Zadro, Debra Shirley, Manuela Ferreira, Ana Paula Carvalho-Silva, Sarah E Lamb, Cyrus Cooper, Paulo H Ferreira
BACKGROUND: Low back pain (LBP) is the highest contributor to disability worldwide, with current intervention strategies only providing small to moderate analgesic effects. The use of vitamin D supplementation for LBP has gained interest due to its proposed anti-inflammatory and neuromodulatory properties. However, it is still unclear whether vitamin D levels differ between those with and without LBP or if vitamin D levels are associated with pain intensity. OBJECTIVES: We aim to investigate the association between vitamin D levels and LBP and to determine if vitamin D levels correlate with pain intensity in individuals with LBP...
November 2017: Pain Physician
https://www.readbyqxmd.com/read/28928494/systematic-review-and-meta-analyses-of-the-difference-between-the-spinal-level-of-the-palpated-and-imaged-iliac-crests
#15
Robert Cooperstein, Felisha Truong
OBJECTIVE: The purpose of this study was to undertake a systematic review of the literature to determine and compare, for patient sub-groups, the spinal level of the iliac crests as commonly measured through manual palpation and radiographic imaging procedures. METHODS: Relevant citations were retrieved by searching the PubMed, ICL, CINAHL, AMED, Osteopathic Research Web, OstMed, and MANTIS biomedical databases, and included articles were rated for quality. Search terms included Tuffier*, intercristal line, intercrestal line, Jacoby's line, lumbar spine, lumbar landmark, pelvic landmark, palpation, and TL (Tuffier's Line)...
August 2017: Journal of the Canadian Chiropractic Association
https://www.readbyqxmd.com/read/28922883/proximal-junctional-kyphosis-prevention-strategies-a-video-technique-guide
#16
Michael M Safaee, Joseph A Osorio, Kushagra Verma, Shay Bess, Christopher I Shaffrey, Justin S Smith, Robert Hart, Vedat Deviren, Christopher P Ames
BACKGROUND: Proximal junctional kyphosis (PJK) is a well-recognized complication in patients undergoing posterior instrumented fusion procedures for adult spinal deformity. Strategies that reduce rates of PJK have the potential to improve the safety of these operations and decrease cost by eliminating the need for revision surgery. OBJECTIVE: To present a set of surgical techniques that can decrease rates of PJK in adults undergoing surgery for spinal deformity...
October 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28874162/isolation-and-characterization-of-the-compounds-responsible-for-the-antimutagenic-activity-of-combretum-microphyllum-combretaceae-leaf-extracts
#17
Tshepiso Jan Makhafola, Esameldin Elzein Elgorashi, Lyndy Joy McGaw, Maurice Ducret Awouafack, Luc Verschaeve, Jacobus Nicolaas Eloff
BACKGROUND: Mutations play a major role in the pathogenesis and development of several chronic degenerative diseases including cancer. It follows, therefore that antimutagenic compound may inhibit the pathological process resulting from exposure to mutagens. Investigation of the antimutagenic potential of traditional medicinal plants and compounds isolated from plant extracts provides one of the tools that can be used to identify compounds with potential cancer chemopreventive properties...
September 6, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28843451/physiotherapy-interventions-for-people-with-dementia-and-a-hip-fracture-a-scoping-review-of-the-literature
#18
REVIEW
A J Hall, I A Lang, R Endacott, A Hall, V A Goodwin
BACKGROUND: People with dementia are 2.7 times more likely to suffer a hip fracture than those without and their management is estimated to cost £0.92 billion per year. Yet there has been little focus on the effectiveness of interventions for this population. OBJECTIVE: The aim of this scoping review was to summarise the current available evidence for physiotherapy interventions for people with dementia who fracture their hip as well as to identify gaps in the literature that may require further research...
December 2017: Physiotherapy
https://www.readbyqxmd.com/read/28815388/guiding-patients-toward-the-appropriate-surgical-treatment-for-obesity-should-presurgery-psychological-correlates-influence-choice-between-roux-en-y-gastric-bypass-and-vertical-sleeve-gastrectomy
#19
Gretchen E Ames, Michael G Heckman, Nancy N Diehl, Dustin M Shepherd, Allison A Holgerson, Karen B Grothe, Todd A Kellogg, Steven P Bowers, Matthew M Clark
BACKGROUND: Helping patients determine which type of bariatric surgery, Roux-en-Y gastric bypass (RYGB) or vertical sleeve gastrectomy (VSG), may be the best treatment can be challenging. This study investigated psychological correlates and their influence on weight loss for patients who underwent RYGB or VSG. METHODS: Four hundred twenty-two patients (RYGB = 305; VSG = 117) completed screening questionnaires presurgery and underwent surgery between August 2012 and April 2015...
October 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28697991/carbamazepine-effects-on-pain-management-and-serum-il-6-il-10-evaluation-in-addicted-patients-undergoing-surgery
#20
Alireza Salimi, Masoumeh Sabetkasaei, Hanna Raisi, Farzaneh Labibi, Haleh Ameli, Yalda Khazaei-Poul, Malek Zarei, Kamran Mottaghi, Farhad Safari, Ali Nazem-Bokaei, Seyed-Amir Mohajerani, Taraneh Moini-Zanjani
Postoperative pain control remains an important issue in the field of surgery. Assessing and managing patients with acute pain who are addicted to opioids are often challenging. It has been shown that, addicted patients are less tolerant to pain. There is limited evidence to guide the management of acute pain in these patients. Here we studied the effect of preemptive use of carbamazepine on pain behavior and serum IL-6, IL-10 levels in the addicted patients. 90 male patients (25-45 years, BMI 20-27), were divided into 3 group of 30 patients: 1- control, 2- addicted, 3- addicted patients receiving carbamazepine 400mg before surgery...
July 8, 2017: European Journal of Pharmacology
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