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Pseudomyxoma

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https://www.readbyqxmd.com/read/29719746/sister-mary-joseph-nodule-as-a-cutaneous-manifestation-of-metastatic-appendiceal-adenocarcinoma-case-report-and-literature-review
#1
Raghavendra L Girijala, Ryan R Riahi, Philip R Cohen
Sister Mary Joseph nodule (SMJN) is an uncommon pattern of superficial periumbilical tumor metastasis, with the primary tumor most commonly associated with gynecological or gastrointestinal origins. This manifestation can represent extensive tumor development from any of the intra-abdominal or pelvic structures. Therefore, SMJN carries a poor prognosis, with a two-year survival rate of only 13.5 percent regardless of the etiology of primary cancer. In this case, a 67-year-old man with metastatic mucinous adenocarcinoma of the appendix involving the umbilicus presenting more than five years after the initial cancer diagnosis is reported...
February 28, 2018: Curēus
https://www.readbyqxmd.com/read/29691625/cytoreductive-surgery-and-intraperitoneal-hyperthermic-chemotherapy-hipec-by-minimally-invasive-approach-an-initial-experience
#2
A Arjona-Sanchez, S Rufian-Peña, J M Sanchez-Hidalgo, A Casado-Adam, A Cosano-Alvarez, J Briceño-Delgado
BACKGROUND: The cytoreductive surgery (CRS) associated with hyperthermic intraperitoneal chemotherapy (HIPEC) has become the standard treatment in patients with carcinomatosis peritoneal from different origins. The use of a minimally invasive approach for this high complex procedure might be an alternative that provides them less morbidity and faster recovery with similar oncologic outcomes. METHODS: We describe the initial experience of CRS and HIPEC done via the laparoscopic route in patients with minimal peritoneal metastases in our Unit from March 2016 to January 2018...
April 24, 2018: World Journal of Surgery
https://www.readbyqxmd.com/read/29624505/impact-of-concomitant-urologic-intervention-on-clinical-outcomes-after-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#3
Akshat Saxena, Winston Liauw, Sohaib A Virk, David L Morris
INTRODUCTION: The impact of concomitant urologic procedures (UPs) on perioperative and long-term outcomes after cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) is uncertain. METHODS: In total, 935 consecutive CRS/HIPEC procedures were performed between 1996 and 2016 in Sydney, Australia. Among these, 73 (7.8%) involved concomitant UP. The association of concomitant UP with 21 perioperative outcomes and overall survival was assessed using univariate and multivariate analyses...
April 5, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29593930/mucinous-carcinomatosis-a-rare-association-between-an-ovarian-tumor-and-an-e-gist
#4
Hugo Palma Rios, André Goulart, Pedro Leão
Pseudomyxoma peritonei (PMP) and extragastrointestinal stromal tumors (E-GISTs) are both rare entities. Most of the time, PMP is associated with an appendiceal tumor. An ovarian mucinous tumor can mimic appendiceal metastases. E-GIST is a mesenchymal tumor that can arise from the omentum, retroperitoneum, mesentery, or pleura. We present a case of an 87-year-old woman with mucinous carcinomatosis and acute intestinal occlusion submitted to an emergency laparotomy. She has found to have a borderline mucinous tumor of the ovary from the intestinal type with several lesions of pseudomyxoma peritonei and an E-GIST from the epiploons retrocavity (intermediated risk)...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29589675/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-risk-factors-for-morbidity-and-postoperative-outcome
#5
Manuela Robella, Marco Vaira, Armando Cinquegrana, Alice Borsano, Michele DE Simone
BACKGROUND: Cytoreductive surgery (CRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC) represents a treatment option for peritoneal surface malignancies. Even if it has been reported that this new approach improved survival of selected patients, it's still associated with high morbidity and mortality rates. METHODS: From October 1995 to December 2017, over 450 patients patients affected by peritoneal carcinomatosis (PC) underwent in our Institute to CRS associated with HIPEC...
March 28, 2018: Minerva Chirurgica
https://www.readbyqxmd.com/read/29564494/mucinous-appendiceal-neoplasms-pathologic-classification-clinical-implications-imaging-spectrum-and-mimics
#6
REVIEW
Alanna Van Hooser, Todd R Williams, Daniel T Myers
Mucinous appendiceal neoplasms are uncommon, but important to recognize with imaging due to malignant potential. Peritoneal seeding and pseudomyxoma peritonei can occur with both frankly malignant as well as low-grade appendiceal neoplasms. Prospective imaging identification of potential appendiceal neoplasm is paramount to clinical/surgical management. When a mucinous appendiceal neoplasm is suspected, a right hemicolectomy with lymph node dissection is the preferred surgical management. Unfortunately, accurate preoperative diagnosis can be challenging due to a wide range of clinical presentations and overlapping imaging appearances of appendiceal neoplasms with benign entities...
March 21, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29534359/-clinicopathologic-characteristics-of-pseudomyxoma-peritonei
#7
Q Zhou, F Shi, H Y Zhao, Y Li, Q K Song
Objective: To analyze the relationship between clinicopathologic characteristics of pseudomyxoma peritonei (PMP) and its prognosis. Methods: Fifty-two cases of PMP collected from 2012 to 2017 at Beijing Shijitan Hospital, Capital Medical University were reviewed using the diagnostic criteria of WHO 2010. The histopathologic features, including original location, neural invasion and calcification were observed; and the relationship with prognosis was analyzed. Immunohistochemical staining for CK7, CK20 and CDX2 was performed on all cases...
March 8, 2018: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29521268/pseudomyxoma-peritonei-a-case-report-and-review-of-the-literature
#8
Juan Gómez Rivas, José María Alonso-Dorrego, Diego M Carrión, Mónica Vega Robalino, Pilar González-Peramato
OBJECTIVE: We present the case of a patient incidentally diagnosed with a pelvic mass next to the bladder. After surgical excision, definitive diagnosis was pseudomyxoma peritonei. We provide a concise review of the literature of this pathology. METHODS: A 55 year-old male patient, was found to have, in annual routine ultrasound, a pelvic retrovesical mass. CT guided needle aspirate showed a tumor with myxoid changes and low aggressive cytology. Surgical excision was performed...
March 2018: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/29502336/impact-of-ovarian-metastases-on-survival-in-patients-treated-with-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-peritoneal-malignancy-of-appendiceal-and-colorectal-cancer-origin
#9
Mark B Bignell, Akash M Mehta, Sue Alves, Kandiah Chandrakumaran, Sanjeev P Dayal, Faheez Mohamed, Tom D Cecil, Brendan J Moran
AIM: Ovarian metastases from gastrointestinal tract malignancy have been considered an ominous finding with poor prognosis. The aim of this project was to determine the impact on survival, and potential cure, when cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are combined to treat peritoneal malignancy in women with Krukenberg tumours. METHOD: Retrospective analysis of prospectively collected data between January 2010 and July 2015...
March 4, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29487003/satb2-is-a-supportive-marker-for-the-differentiation-of-a-primary-mucinous-tumor-of-the-ovary-and-an-ovarian-metastasis-of-a-low-grade-appendiceal-mucinous-neoplasm-lamn-a-series-of-seven-cases
#10
Elisa Schmoeckel, Thomas Kirchner, Doris Mayr
The differentiation between a primary mucinous ovarian neoplasm and an extra-ovarian metastasis in the ovary is often challenging in the histopathologic practice. Among various ovarian metastases from the gastro-intestinal tract the low-grade appendiceal mucinous neoplasm (LAMN) is an important differential diagnosis to consider particularly in case of pseudomyxoma peritonei. A newly recognized marker in the routine diagnostic of a mucinous neoplasm in the ovary is SATB2 (Special AT-rich sequence-binding protein 2)...
March 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29412465/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-pseudomyxoma-peritonei-of-appendicular-and-extra-appendicular-origin
#11
J-B Delhorme, F Severac, G Averous, O Glehen, G Passot, N Bakrin, F Marchal, M Pocard, R Lo Dico, C Eveno, S Carrere, O Sgarbura, F Quenet, G Ferron, D Goéré, C Brigand
BACKGROUND: The prognostic value of the primary neoplasm responsible for pseudomyxoma peritonei (PMP) remains poorly studied. The aim of this study was to determine the prognosis for patients with extra-appendicular PMP (EA-PMP) treated optimally with complete cytoreductive surgery (CCRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). METHODS: All patients treated for PMP with CCRS and HIPEC between 1994 and 2016 were selected retrospectively from a French multicentre database...
May 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29406206/mucinous-neoplasm-of-the-appendix-and-pseudomyxoma-peritonei
#12
Lori A Erickson, Michael Rivera
No abstract text is available yet for this article.
February 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29374723/low-dose-pressurized-intrathoracic-aerosol-chemotherapy-pitac-as-an-alternative-therapy-for-pleuropulmonary-involvement-in-pseudomyxoma-peritonei
#13
Manuela Robella, Marco Vaira, Alice Borsano, Claudio Mossetti, Michele DE Simone
BACKGROUND/AIM: Pseudomyxoma peritonei (PMP) is a rare disease characterized by mucinous ascites and widespread peritoneal implants. It usually originates from the rupture of an adenoma/adenocarcinoma of the appendix. Although this tumor is only superficially invasive and does not metastasize, it could be a fatal disease. Extra-abdominal spread of PMP is an unusual occurrence with few reports in medical literature. CASE REPORT: A 50-year-old man was diagnosed with PMP according to the findings of thorax and abdomen CT scan and cytologic and histological examinations...
February 2018: Anticancer Research
https://www.readbyqxmd.com/read/29334144/acute-gastrointestinal-bleeding-from-appendiceal-diverticulitis-diagnosed-preoperatively-by-combined-short-interval-computed-tomography-and-colonoscopy-a-case-report
#14
Yutaro Ogawa, Naoki Asayama, Shinji Nagata
No abstract text is available yet for this article.
January 15, 2018: Digestive Endoscopy: Official Journal of the Japan Gastroenterological Endoscopy Society
https://www.readbyqxmd.com/read/29313146/long-term-quality-of-life-after-cytoreductive-surgery-and-heated-intraperitoneal-chemotherapy-for-pseudomyxoma-peritonei-a-prospective-longitudinal-study
#15
Adam T Stearns, Lee Malcomson, Grant Punnett, Haytham Abudeeb, Omer Aziz, Chelliah R Selvasekar, Paul E Fulford, Malcolm S Wilson, Andrew G Renehan, Sarah T O'Dwyer
BACKGROUND: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) are an established treatment for pseudomyxoma peritonei (PMP), but it is a major surgical procedure and may be associated with long-term morbidity. To date, health-related quality-of-life (HRQL) data among survivors are lacking. METHODS: A two-period qualitative study investigated patients undergoing CRS-HIPEC for PMP at a national peritoneal tumor center between 2003 and 2011...
April 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29290997/targeting-g-protein-coupled-receptor-related-signaling-pathway-in-a-murine-xenograft-model-of-appendiceal-pseudomyxoma-peritonei
#16
Ashok K Dilly, Brendon D Honick, Yong J Lee, Zong S Guo, Herbert J Zeh, David L Bartlett, Haroon A Choudry
Cancer cells aberrantly express mucins to enhance their survival. Relative chemoresistance of appendiceal pseudomyxoma peritonei (PMP) is attributed to abundant extracellular mucin 2 (MUC2) protein production. We hypothesized that simultaneous MUC2 inhibition and apoptosis induction would be effective against mucinous tumors. In vitro studies were conducted using LS174T cells (MUC2-secreting human colorectal cancer cells), PMP explant tissue, and epithelial organoid cultures (colonoids) derived from mucinous appendix cancers...
December 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/29238881/peritoneal-carcinomatosis-of-urachus-origin-treated-by-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-hipec-an-international-registry-of-36-patients
#17
Frederic Mercier, Guillaume Passot, Laurent Villeneuve, Edward A Levine, Yutaka Yonemura, Diane Goéré, Paul H Sugarbaker, Christelle Marolho, David L Bartlett, Olivier Glehen
PURPOSE: Peritoneal carcinomatosis or pseudomyxoma peritonei from urachus is a rare form of presentation, often diagnosed at an advanced state of tumor burden. Because of its rarity, little is known about its natural history, prognosis, or optimal treatment. We searched a large international multicenter database of peritoneal surface disease to identify cases of peritoneal carcinomatosis of urachus that were treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) at expert centers...
April 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29203986/crs-and-hipec-for-pmp-use-of-the-lc-cusum-to-determine-the-number-of-procedures-required-to-attain-a-minimal-level-of-proficiency-in-delivering-the-combined-modality-treatment
#18
Aditi Bhatt, Antony George, Sanket Mehta
The learning curve for cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for pseudomyxoma peritonei (PMP) which peaks at 90 procedures for the surgeon may take several years to reach. The cumulative summation (CUSUM) test of the learning curve (LC-CUSUM) was used to assess the safety of the procedure (minimal level of proficiency for the surgeon) in terms of morbidity, mortality, and completeness of cytoreduction and early oncological failure before the peak of the learning curve had been reached...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29192372/prediction-of-resectability-in-pseudomyxoma-peritonei-with-a-new-ct-score
#19
Morgane Bouquot, Anthony Dohan, Etienne Gayat, Maxime Barat, Olivier Glehen, Marc Pocard, Pascal Rousset, Clarisse Eveno
BACKGROUND: Curative treatment of pseudomyxoma peritonei (PMP) is complete cytoreductive surgery (CRS) with hyperthermic intraperitoneal chemotherapy (HIPEC). OBJECTIVE: The aim of this study was to build and evaluate a preoperative imaging score to predict resectability. PATIENTS AND METHODS: Between 2007 and 2014, all PMP patients in two tertiary reference centers who underwent laparotomy with intent to undergo CRS and HIPEC were included in this study retrospectively...
March 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29185227/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-in-the-management-of-pseudomyxoma-peritonei-a-single-center-experience
#20
Ayman Zaki Azzam, Zyad Adil Alyahya, Ahmed Abbas Al Wusaibie, Tarek Mahmoud Amin
BACKGROUND AND AIMS: Pseudomyxoma peritonei (PMP) results from perforated appendiceal tumors. It is usually diagnosed preoperatively by imaging. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC), although aggressive long procedure with high complications rate, was considered the optimal treatment. This study is aiming to study the role of CRS and HIPEC in the management of PMP and assess the outcome. METHODS: This is a retrospective study which was conducted at King Faisal Hospital and Research Center, a tertiary care hospital during the period from November 2008 to June 2016...
November 2017: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
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