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Pseudomyxoma

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https://www.readbyqxmd.com/read/29159742/validation-of-the-recent-psogi-pathological-classification-of-pseudomyxoma-peritonei-in-a-single-center-series-of-265-patients-treated-by-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#1
Dario Baratti, Shigeki Kusamura, Massimo Milione, Federica Bruno, Marcello Guaglio, Marcello Deraco
BACKGROUND: Controversies still persist regarding the terminology and pathologic classification of appendiceal mucinous neoplasms and associated pseudomyxoma peritonei (PMP). We assessed reproducibility and prognostic significance of the classification recently proposed by the Peritoneal Surface Oncology Group International (PSOGI). METHODS: A prospective database of 265 PMP patients uniformly treated by cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) from 1995 to 2017 was reviewed...
November 20, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29110275/impact-of-cellularity-on-oncologic-outcomes-following-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemoperfusion-for-pseudomyxoma-peritonei
#2
Haroon A Choudry, Reetesh K Pai, Yongli Shuai, Lekshmi Ramalingam, Heather L Jones, James F Pingpank, Steven S Ahrendt, Matthew P Holtzman, Amer H Zureikat, Herbert J Zeh, David L Bartlett
BACKGROUND: The Peritoneal Surface Oncology Group International (PSOGI) recommends pathologic reporting of tumor cellularity in patients with pseudomyxoma peritonei (PMP) undergoing cytoreductive surgery and hyperthermic intraperitoneal chemoperfusion (CRS-HIPEC). We investigated the prognostic significance of PMP cellularity, or lack thereof (acellular mucin), following CRS-HIPEC. METHODS: We reviewed clinical data for 310 CRS-HIPEC procedures in low-grade (American Joint Committee on Cancer grade G1) PMP with acellular mucin (n = 19), scant cellularity (n = 30), or moderate cellularity (n = 242)...
November 6, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29070005/cecal-endometriosis-with-intestinal-metaplasia-misdiagnosed-as-neoplasm-of-the-cecum-by-intraoperative-histological-examination
#3
Xinge Fu, Juhong Jiang, Bin Li, Xiao-Ying Tian, Zhi Li
Appendiceal or cecal endometriosis with intestinal metaplasia is uncommon and may mimic mucinous tumors of the appendix. A 50-year-old woman was found incidentally to have an ileocecal lesion. In the intraoperative histological examination, a diagnosis of neoplasm of the cecum was made predominantly based on mucin extrusion with scattered lining mucinous epithelium. However, postoperative histological diagnosis of the lesion was cecal endometriosis with intestinal metaplasia as determined by thoroughly microscopic inspection and the presence of typical endometrial glands with surrounding endometrial-type stroma...
October 1, 2017: International Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29063804/the-pre-operative-neutrophil-lymphocyte-ratio-predicts-overall-and-disease-free-survival-following-cytoreductive-surgery-crs-and-hyperthermic-intraperitoneal-chemotherapy-hipec-in-patients-with-pseudomxyoma-peritonei-of-appendiceal-origin
#4
Karan Rangarajan, Kandiah Chandrakumaran, Sanjeev Dayal, Faheez Mohamed, Brendan J Moran, Thomas D Cecil
AIM: The neutrophil-lymphocyte ratio (NLR) and other inflammation-based scores have been used as a prognostic tool to predict survival in solid tumours including pseudomyxoma peritonei (PMP). The aim was to evaluate the prognostic value of this marker and risk stratify PMP patients undergoing cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). METHODS: Retrospective analysis was conducted of a prospectively collected database of patients with PMP who underwent CRS and HIPEC between 1994 and 2015...
October 24, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29024737/pseudomyxoma-peritonei-arising-from-urachal-mucinous-adenocarcinoma
#5
Panagiotis Dimopoulos, Spyridon Kampantais, Simon Payne, Sidath Liyanage
Pseudomyxoma peritonei is a rare clinical condition which can arise from various primary tumors with different biological behaviour. An intraperitoneal spread of mucus is the characteristic of the disease. Here we provide images from a rare entity, a pseudomyxoma peritonei arising from urachal mucinous adenocarcinoma. If clinical suspicion is high, the preoperative imaging could be almost pathognomonic of the disease.
October 9, 2017: Urology
https://www.readbyqxmd.com/read/29019584/a-proposal-of-brazilian-society-of-surgical-oncology-for-standardizing-cytoreductive-surgery-plus-hypertermic-intraperitoneal-chemotherapy-procedures-in-brazil-pseudomixoma-peritonei-appendiceal-tumors-and-malignant-peritoneal-mesothelioma
#6
Thales Paulo Batista, Bruno José Queiroz Sarmento, Janina Ferreira Loureiro, Andrea Petruzziello, Ademar Lopes, Cassio Cortez Santos, Cláudio de Almeida Quadros, Eduardo Hiroshi Akaishi, Eduardo Zanella Cordeiro, Felipe José Fernández Coimbra, Gustavo Andreazza Laporte, Leonaldson Santos Castro, Ranyell Matheus Spencer Sobreira Batista, Samuel Aguiar, Wilson Luiz Costa, Fábio Oliveira Ferreira
Cytoreductive surgery plus hypertermic intraperitoneal chemotherapy has emerged as a major comprehensive treatment of peritoneal malignancies and is currently the standard of care for appendiceal epithelial neoplasms and pseudomyxoma peritonei syndrome as well as malignant peritoneal mesothelioma. Unfortunately, there are some worldwide variations of the cytoreductive surgery and hypertermic intraperitoneal chemotherapy techniques since no single technique has so far demonstrated its superiority over the others...
September 2017: Revista do Colégio Brasileiro de Cirurgiões
https://www.readbyqxmd.com/read/29016471/an-update-on-the-diagnosis-grading-and-staging-of-appendiceal-mucinous-neoplasms
#7
Mark A Valasek, Reetesh K Pai
Despite advances in our understanding of appendiceal mucinous neoplasms and their relationship to the pseudomyxoma peritonei syndrome, the classification of mucinous tumors of the appendix is still confusing. This review will provide an update on the various classification systems that have been recently proposed for appendiceal mucinous neoplasia, with a particular emphasis on how to handle and report the histologic findings for these tumors using the newly published Peritoneal Surface Oncology Group International (PSOGI) and American Joint Committee on Cancer (AJCC) eighth edition guidelines...
October 9, 2017: Advances in Anatomic Pathology
https://www.readbyqxmd.com/read/28993033/ca-19-9-to-peritoneal-carcinomatosis-index-pci-ratio-is-prognostic-in-patients-with-epithelial-appendiceal-mucinous-neoplasms-and-peritoneal-dissemination-undergoing-cytoreduction-surgery-and-intraperitoneal-chemotherapy-a-retrospective-cohort-study
#8
Mathew A Kozman, Oliver M Fisher, Bree-Anne J Rebolledo, Sarah J Valle, Nayef Alzahrani, Winston Liauw, David L Morris
BACKGROUND: Serum tumour levels have been shown to be prognostic in patients with epithelial appendiceal mucinous neoplasms with peritoneal dissemination (pseudomyxoma peritonei (PMP)). A singular index which incorporates both tumour activity (as depicted by serum tumour marker levels) and tumour volume (as depicted by peritoneal carcinomatosis index (PCI)), may give a more precise surrogate of tumour biological behaviour. The prognostic implication of this index has not yet been reported...
September 19, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28986751/total-mesenteric-peritonectomy-for-peritoneal-metastases-with-video
#9
Jean-Baptiste Cazauran, Antoinette Lasseur, Arnaud Pasquer, Pascal Rousset, Jeremy Guedj, Guillaume Passot, Olivier Glehen
BACKGROUND: Complete cytoreductive surgery (CRS), combining organ resection and peritonectomy, is the only potentially curative treatment for patients with peritoneal metastases (PM).1 (,) 2 Diffuse mesenteric PM usually represents a contraindication for CRS.3 This report presents a standardized total mesenteric peritonectomy, which provides a therapeutic option of complete CRS for patients with diffuse mesenteric PM. PATIENT: A 73-year-old man had a diagnosis of PM caused by an urachal adenocarcinoma (signet cell type)...
October 6, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28975983/hiv-patient-with-pseudomyxoma-peritonei-of-extra-appendiceal-origin-is-disease-free-and-alive-9-years-after-complete-cytoreductive-surgery
#10
A Tampakis, E C Tampaki, P Alexandrou, K Kontzoglou, G Kouraklis
OBJECTIVE: Pseudomyxoma peritonei (PMP) is a clinical syndrome that is mainly characterized by the presence of mucinous ascites that results from the rupture of a mucin-producing neoplasm. No reports exist so far regarding the management of this syndrome in HIV patients. CASE REPORT: A 54-year old male patient with a diagnosed atypical colitis developed additionally over time a complicated diverticulitis which was initially treated conservatively with antibiotics...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28964609/multicentric-initial-experience-with-the-use-of-the-pressurized-intraperitoneal-aerosol-chemotherapy-pipac-in-the-management-of-unresectable-peritoneal-carcinomatosis
#11
Mohammad Alyami, Johan Gagniere, Olivia Sgarbura, Delphine Cabelguenne, Laurent Villeneuve, Denis Pezet, Francois Quenet, Olivier Glehen, Naoual Bakrin, Guillaume Passot
BACKGROUND: PIPAC is a recent approach for intraperitoneal chemotherapy with promising results for patients with peritoneal carcinomatosis (PC). We aimed to evaluate the postoperative outcome of PIPAC in patients with non-resectable PC during our initial experience of the technique. METHODS: All patients who underwent PIPAC for non-resectable PC in three centers were analyzed regarding postoperative outcomes. RESULTS: Seventy-three patients underwent 164 PIPAC...
September 21, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28858081/urachal-mucinous-adenocarcinoma-with-pseudomyxoma-peritonei-a-case-report
#12
Lei Liang, Nan Zhou, Hongbin Xu, Damiao Liu, Yiyan Lu, Fang Li, Jun Guo
RATIONALE: Pseudomyxoma peritonei is an unusual clinical condition, and the appendix and ovaries are reported as the primary sites. PATIENT CONCERNS: A 44-year-old man who was reported a 3-month history of lower abdominal pain and distention, along with increased abdominal girth, was admitted with a palpable tender mass in the central lower abdomen. DIAGNOSIS: Ultrasonography showed a large well-circumscribed cystic-solid mass with lobulated margin, extending from the anterosuperior dome of the urinary bladder to the anterior abdominal wall...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28852603/palliative-radiation-therapy-for-symptom-control-in-an-advanced-case-of-pseudomyxoma-peritonei
#13
Clare McGrath, Kelly Linden, Pamela Hube, Anna Adamiak, Kristopher Dennis
Pseudomyxoma peritonei (PP) is a rare clinical condition characterized by progressive mucinous ascites, which is typically caused by a mucin-producing neoplasm. Reports of radiation therapy (RT) in the management of PP are limited. We report a unique case of a 62-year-old woman with severe, end-stage, recurrent PP and a large, mucin-secreting mass protruding through her abdominal wall. Low-dose, hypofractionated palliative RT was administered for symptom control with the hope of improving her quality of life...
June 29, 2017: Curēus
https://www.readbyqxmd.com/read/28835081/-the-clinicopathological-features-and-risk-factors-of-recurrence-in-patients-with-mucinous-borderline-ovarian-tumors
#14
L Sun, Y Song, N Li, G W Yuan, Y C Sun, N Li, S K Ma, X Zhang, L Y Wu
Objective: To investigate the clinicopathological features and risk factors in patients with mucinous borderline ovarian tumors (MBOT). Methods: From 1999 to 2006, 66 MBOT patients in our hospital with more than ten-year follow-up were enrolled retrospectively. They were re-classified according to the literature. The clinicopathological features of different subgroups, including age, preoperative serum tumor markers, surgical methods, pathological features, surgical pathology staging, as well as the risk factors of recurrence and survival were analyzed...
August 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28812240/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-for-pseudomyxoma-peritonei-and-appendix-tumours-in-elderly-patients-is-it-justified
#15
V López-López, P A Cascales-Campos, E Gil, J Arevalo, A Gonzalez, J Gil, F C Muñoz-Casares, J T Melero, P Barrios, R Morales, I Ramos, G Ortega, B Camps, L González-Bayón, P Bretcha-Boix, J Farré-Alegre, S González-Moreno, P Parrilla
BACKGROUND: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) for pseudomyxoma peritonei and appendix tumours are widespread in the world. It is unclear what should be the attitude in elderly patients. METHODS: This retrospective multicenter study collected the database from ten Spanish centers from Spanish Group of Peritoneal Cancer Surgery. The study period was between November 2002 and March 2014. Seventeen patients with age greater than or equal to 75 years with peritoneal carcinomatosis from pseudomyxoma peritonei and appendix tumours met the selection criteria for the study...
November 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28746986/the-histopathological-classification-diagnosis-and-differential-diagnosis-of-mucinous-appendiceal-neoplasms-appendiceal-adenocarcinomas-and-pseudomyxoma-peritonei
#16
REVIEW
Norman J Carr, Frederic Bibeau, Robert F Bradley, Peggy Dartigues, Roger M Feakins, Kim R Geisinger, Xianyong Gui, Sylvie Isaac, Massimo Milione, Joseph Misdraji, Reetesh K Pai, Manuel Rodriguez-Justo, Leslie H Sobin, Marie-Louise F van Velthuysen, Rhonda K Yantiss
The vermiform appendix is the primary site of several distinctive benign and malignant neoplasms. Some can produce the clinical syndrome of pseudomyxoma peritonei (PMP). A consensus on their terminology was reached by an international panel of pathologists and clinicians working under the auspices of the Peritoneal Surface Oncology Group International (PSOGI), and this review discusses the application of the PSOGI classification to routine reporting. We discuss diagnosis and differential diagnosis together with implications for patient management, covering low-grade appendiceal mucinous neoplasms, high-grade appendiceal mucinous neoplasms, serrated polyps, adenomas and adenocarcinomas...
July 26, 2017: Histopathology
https://www.readbyqxmd.com/read/28745193/support-when-it-matters-most
#17
Elaine Cole
A healthcare assistant's work to improve the experience of patients with a rare cancer was highly commended at the RCNi Nurse Awards 2017. Elaine Cooney, of Hampshire Hospitals NHS Foundation Trust, was recognised in the RCN Healthcare Assistant category for her work supporting patients with pseudomyxoma peritonei and their families.
July 26, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28737098/abdominal-wall-morbidity-following-cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy
#18
F Struller, I Koenigsrainer, P Horvath, A Koenigsrainer, S Beckert
BACKGROUND: Incisional hernia formation has been reported as high as 20% within 1 year following midline laparotomy. Since hyperthermic intraperitoneal chemotherapy is likely to impair wound healing, we sought to investigate the incidence of incisional hernia formation and abdominal wall rupture following cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. METHODS: Consecutive patients with radiographic evidence of peritoneal metastases were scheduled for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy at the Comprehensive Cancer Center, University Hospital Tuebingen, Germany...
March 1, 2017: Scandinavian Journal of Surgery: SJS
https://www.readbyqxmd.com/read/28732270/unexpected-histopathology-of-acute-appendicitis
#19
Mutee Ur Rehman, Felik Paulus, Min Hoe Chew
INTRODUCTION: Appendicular diverticula and associated diverticulitis is a rare disease. Patients present commonly with symptoms of acute appendicitis and require laparoscopic or open surgery. Diagnosis is usually made only on histology. Here, we present a rare case of acute diverticulitis of the appendix. CASE PRESENTATION: A 33-year old gentleman presented with right iliac fossa pain of 3 days duration. On admission, appendicitis was diagnosed on Computerized Tomography (CT) scan and laparoscopic appendicectomy was subsequently performed...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28727692/short-term-outcomes-following-cytoreductive-surgery-and-heated-intra-peritoneal-chemotherapy-at-waikato
#20
Ngov Jasen Ly, Linus Wu, Ralph Van Dalen, Simione Lolohea
AIM: Pseudomyxoma peritonei is a rare disease that affects 1-2 per million population per year. Treatment with cytoreductive surgery with heated intraperitoneal chemotherapy (CRS with IPC) has been well described. The purpose of this study was to look at the short-term outcomes following CRS with IPC for all such patients treated in Waikato. METHOD: Records for all patients presenting to surgery for CRS with IPC were retrospectively reviewed. CRS with IPC was performed in accordance with the techniques described by Sugarbaker...
July 21, 2017: New Zealand Medical Journal
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