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https://www.readbyqxmd.com/read/28934291/emotional-metacontrol-of-attention-top-down-modulation-of-sensorimotor-processes-in-a-robotic-visual-search-task
#1
Marwen Belkaid, Nicolas Cuperlier, Philippe Gaussier
Emotions play a significant role in internal regulatory processes. In this paper, we advocate four key ideas. First, novelty detection can be grounded in the sensorimotor experience and allow higher order appraisal. Second, cognitive processes, such as those involved in self-assessment, influence emotional states by eliciting affects like boredom and frustration. Third, emotional processes such as those triggered by self-assessment influence attentional processes. Last, close emotion-cognition interactions implement an efficient feedback loop for the purpose of top-down behavior regulation...
2017: PloS One
https://www.readbyqxmd.com/read/28934284/correlation-of-dapk1-methylation-and-the-risk-of-gastrointestinal-cancer-a-systematic-review-and-meta-analysis
#2
Wenzheng Yuan, Jinhuang Chen, Yan Shu, Sanguang Liu, Liang Wu, Jintong Ji, Zhengyi Liu, Qiang Tang, Zili Zhou, Yifeng Cheng, Bin Jiang, Xiaogang Shu
OBJECTIVE: One of the critical mechanisms of gastrointestinal cancer pathogenesis is the silencing of death associated protein kinase 1 (DAPK1), which could be caused by aberrant methylation of the promoter. However, the relationship between DAPK1 methylation and the risk of gastrointestinal cancer is still controversial. Hence, we conducted this study to determine the potential correlation. METHODS: Eligible publications were searched in the Pubmed, Embase, and Cochrane Library through November 2016 according to the inclusion criteria and exclusion criteria...
2017: PloS One
https://www.readbyqxmd.com/read/28934252/three-way-interaction-model-to-trace-the-mechanisms-involved-in-alzheimer-s-disease-transgenic-mice
#3
Nasibeh Khayer, Sayed-Amir Marashi, Mehdi Mirzaie, Fatemeh Goshadrou
Alzheimer's disease (AD) is the most common cause for dementia in human. Currently, more than 46 million people in the world suffer from AD and it is estimated that by 2050 this number increases to more than 131 million. AD is considered as a complex disease. Therefore, understanding the mechanism of AD is a universal challenge. Nowadays, a huge number of disease-related high-throughput "omics" datasets are freely available. Such datasets contain valuable information about disease-related pathways and their corresponding gene interactions...
2017: PloS One
https://www.readbyqxmd.com/read/28934131/tissue-based-micrornas-as-predictors-of-biochemical-recurrence-after-radical-prostatectomy-what-can-we-learn-from-past-studies
#4
REVIEW
Zhongwei Zhao, Carsten Stephan, Sabine Weickmann, Monika Jung, Glen Kristiansen, Klaus Jung
With the increasing understanding of the molecular mechanism of the microRNAs (miRNAs) in prostate cancer (PCa), the predictive potential of miRNAs has received more attention by clinicians and laboratory scientists. Compared with the traditional prognostic tools based on clinicopathological variables, including the prostate-specific antigen, miRNAs may be helpful novel molecular biomarkers of biochemical recurrence for a more accurate risk stratification of PCa patients after radical prostatectomy and may contribute to personalized treatment...
September 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28933895/individual-variability-in-the-semantic-processing-of-english-compound-words
#5
Daniel Schmidtke, Julie A Van Dyke, Victor Kuperman
Semantic transparency effects during compound word recognition provide critical insight into the organization of semantic knowledge and the nature of semantic processing. The past 25 years of psycholinguistic research on compound semantic transparency has produced discrepant effects, leaving the existence and nature of its influence unresolved. In the present study, we examined the influence of semantic transparency and individual reading experience on eye-movement behavior during sentence reading. Eye-movement data were collected from 138 non-college-bound 16- to 26-year-old speakers of English in a sentence-reading task representing a total of 455 different compound words...
September 21, 2017: Journal of Experimental Psychology. Learning, Memory, and Cognition
https://www.readbyqxmd.com/read/28933834/quantum-chemical-insight-into-la2c96-metal-carbide-fullerene-la2c2-c94-versus-dimetallofullerene-la2-c96
#6
Ruisheng Zhao, Kun Yuan, Shengdun Zhao, Xiang Zhao, Masahiro Ehara
A family of dilanthanum-containing endohedral metallofullerene La2C2n (n = 46-51) was synthesized recently. In the present work, a systematical investigation on La2C96 series including the carbide clusterfullerene form La2C2@C94 and the conventional dimetallofullerene form La2@C96 was implemented by density functional theory, combined with statistical mechanics. Three isomers, i.e., La2@D2(191838)-C96, La2C2@Cs(153479)-C94, and La2C2@C1(153491)-C94 were disclosed to be thermodynamically stable at the temperature region of endohedral metallofullerene formation...
September 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28933187/headless-screw-fixation-of-metacarpal-neck-fractures-a-mechanical-comparative-analysis
#7
Christopher M Jones, Eric M Padegimas, Nicole Weikert, Samuel Greulich, Asif M Ilyas, Sorin Siegler
BACKGROUND: The purpose of this study was to compare the mechanical properties of metacarpal neck fracture fixation by headless compression screw (HCS) with that of Kirschner wire (KW) cross-pinning and locking plate (LP) fixation. METHODS: A metacarpal neck fracture was created in 30 fourth-generation composite Sawbones metacarpal models. A volar-based wedge was removed using a custom jig to simulate a typical apex dorsal fracture, unstable in flexion. The models were divided into 3 equal groups based on the method of fixation: retrograde cross-pinning with two 1...
September 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28933132/effects-of-secukinumab-on-serum-adipocytokines-preliminary-data
#8
A Fassio, D Gatti, P Gisondi, G Girolomoni, O Viapiana, A Giollo, M Zamboni, M Rossini, L Idolazzi
Psoriatic arthritis (PsA) is a chronic inflammatory disease that affects joints, connective tissues and the axial skeleton. Metabolic syndrome is an independent risk factor for psoriasis (Pso) development and is associated with more severe forms of Pso. Adipocytokines are secreted by white adipose tissue and are thought to link obesity with the development of metabolic and cardiovascular diseases. Secukinumab is a new monoclonal antibody with a different mechanism of action. This antibody selectively binds to and neutralizes interleukin-17 (IL-17) and it has shown efficacy in the treatment of PsA...
September 21, 2017: Reumatismo
https://www.readbyqxmd.com/read/28932827/partitioning-based-mechanisms-under-personalized-differential-privacy
#9
Haoran Li, Li Xiong, Zhanglong Ji, Xiaoqian Jiang
Differential privacy has recently emerged in private statistical aggregate analysis as one of the strongest privacy guarantees. A limitation of the model is that it provides the same privacy protection for all individuals in the database. However, it is common that data owners may have different privacy preferences for their data. Consequently, a global differential privacy parameter may provide excessive privacy protection for some users, while insufficient for others. In this paper, we propose two partitioning-based mechanisms, privacy-aware and utility-based partitioning, to handle personalized differential privacy parameters for each individual in a dataset while maximizing utility of the differentially private computation...
May 2017: Adv Knowl Discov Data Min (2017)
https://www.readbyqxmd.com/read/28932576/outcomes-after-lung-transplantation
#10
REVIEW
Gabriel Thabut, Herve Mal
With more than 50,000 procedures having been performed worldwide, lung transplantation (LT) has become the standard of care for patients with end-stage chronic respiratory failure. LT leads to dramatic improvements in both pulmonary function and health related quality of life. Survival after LTs has steadily improved, but still lags far behind that observed after other solid organ transplantations, as evidenced by a median survival rate that currently stands at 5.8 years. Because of these disappointing results, the ability of LT to expand survival has been questioned...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28932552/chylothorax-after-pediatric-cardiac-surgery-complicates-short-term-but-not-long-term-outcomes-a-propensity-matched-analysis
#11
Nikoletta R Czobor, György Roth, Zsolt Prodán, Daniel J Lex, Erzsébet Sápi, László Ablonczy, Mihály Gergely, Edgar A Székely, János Gál, Andrea Székely
BACKGROUND: The occurrence of postoperative chylothorax in children with congenital heart disease is a rare and serious complication in cardiac intensive care units (ICUs). The aim of our study was to identify the perioperative characteristics, treatment options, resource utilization and long term complications of patients having chylothorax after a pediatric cardiac surgery. METHODS: Patients were retrospectively assessed for the presence of chylothorax between January 2002 and December 2012 in a tertiary national cardiac center...
August 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28932503/effect-of-high-tibial-osteotomy-on-hip-biomechanics-in-patients-with-genu-varum-a%C3%A2-prospective-cohort-study
#12
Mehdi Moghtadaei, Ali Yeganeh, Bahram Boddouhi, Atefe Alaee, Hossein Farahini, Babak Otoukesh
BACKGROUND AND AIMS: The aim of this study is to evaluate the effect of proximal tibia osteotomy on hip biomechanics. METHODS: This cohort study was conducted on 50 knees of 37 patients divided into two groups of unilateral and bilateral surgeries during 2015-2016. Patients underwent medial open-wedge osteotomy of proximal tibia. Axial alignment of lower limb radiography was carried out for the patients before and after the osteotomy. RESULTS: Findings from unilateral and bilateral high tibial osteotomies demonstrated that the average of greater trochanter (GT) angle from femoral head center and also the average angle of knee varus were significantly decreased (P = 0...
June 2017: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/28932080/comparison-between-tocotrienol-and-omeprazole-on-gastric-growth-factors-in-stress-exposed-rats
#13
Mohd Fahami Nur Azlina, Hj Mohd Saad Qodriyah, Kien Hui Chua, Yusof Kamisah
AIM: To investigate and compare the effects of tocotrienol and omeprazole on gastric growth factors in rats exposed to water-immersion restraint stress (WIRS). METHODS: Twenty-eight male Wistar rats were randomly assigned to four groups of seven rats. The two control groups were administered vitamin-free palm oil (vehicle) and the two treatment groups were given omeprazole (20 mg/kg) or tocotrienol (60 mg/kg) by oral gavage. After 28 d of treatment, rats from one control group and both treated groups were subjected to WIRS one time for 3...
August 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28932048/use-of-jaggery-and-honey-as-adjunctive-cytological-fixatives-to-ethanol-for-oral-smears
#14
Deepak Pandiar, Harakh Chand Baranwal, Sandip Kumar, Vellaichamy Ganesan, Piyush Kumar Sonkar, Kausik Chattopadhyay
BACKGROUND: Ethanol has satisfactorily been used as cyto-fixative. Owing to its limitations, pathologists have always searched for new fixatives. The present study was conducted to evaluate the efficacy of two natural sweeteners as cyto-fixatives. An attempt has also been made to understand the underlying mechanism by which these fixatives fix the oral mucosal cells. MATERIALS AND METHODS: Three smears were collected from 25 healthy volunteers. One smear was fixed in ethanol and the other two in 20% aqueous honey solution and 30% aqueous jaggery solution for 15-30 min followed by Papanicolaou staining...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28931738/biological-and-statistical-processes-jointly-drive-population-aggregation-using-host-parasite-interactions-to-understand-taylor-s-power-law
#15
Pieter T J Johnson, Mark Q Wilber
The macroecological pattern known as Taylor's power law (TPL) represents the pervasive tendency of the variance in population density to increase as a power function of the mean. Despite empirical illustrations in systems ranging from viruses to vertebrates, the biological significance of this relationship continues to be debated. Here we combined collection of a unique dataset involving 11 987 amphibian hosts and 332 684 trematode parasites with experimental measurements of core epidemiological outcomes to explicitly test the contributions of hypothesized biological processes in driving aggregation...
September 27, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28931430/global-proteomic-profiling-of-yersinia-ruckeri-strains
#16
Gokhlesh Kumar, Karin Hummel, Timothy J Welch, Ebrahim Razzazi-Fazeli, Mansour El-Matbouli
Yersinia ruckeri is the causative agent of enteric redmouth disease (ERM) of salmonids. There is little information regarding the proteomics of Y. ruckeri. Herein, we perform whole protein identification and quantification of biotype 1 and biotype 2 strains of Y. ruckeri grown under standard culture conditions using a shotgun proteomic approach. Proteins were extracted, digested and peptides were separated by a nano liquid chromatography system and analyzed with a high-resolution hybrid triple quadrupole time of flight mass spectrometer coupled via a nano ESI interface...
September 20, 2017: Veterinary Research
https://www.readbyqxmd.com/read/28931035/neuroprotection-with-hypothermia-and-allopurinol-in-an-animal-model-of-hypoxic-ischemic-injury-is-it-a-gender-question
#17
Javier Rodríguez-Fanjul, Cristina Durán Fernández-Feijóo, Míriam Lopez-Abad, Maria Goretti Lopez Ramos, Rafael Balada Caballé, Soledad Alcántara-Horillo, Marta Camprubí Camprubí
BACKGROUND: Hypoxic-ischemic encephalopathy (HIE) is one of the most important causes of neonatal brain injury. Therapeutic hypothermia (TH) is the standard treatment for term newborns after perinatal hypoxic ischemic injury (HI). Despite this, TH does not provide complete neuroprotection. Allopurinol seems to be a good neuroprotector in several animal studies, but it has never been tested in combination with hypothermia. Clinical findings show that male infants with (HI) fare more poorly than matched females in cognitive outcomes...
2017: PloS One
https://www.readbyqxmd.com/read/28931001/an-automated-rapid-iterative-negative-geotaxis-assay-for-analyzing-adult-climbing-behavior-in-a-drosophila-model-of-neurodegeneration
#18
Wenze Cao, Li Song, Jingjing Cheng, Na Yi, Luyi Cai, Fu-de Huang, Margaret Ho
Neurodegenerative diseases are frequently associated with a progressive loss of movement ability, reduced life span, and age-dependent neurodegeneration. To understand the mechanism of these cellular events, and their causal relationships with each other, Drosophila melanogaster, with its sophisticated genetic tools and diverse behavioral features, are used as disease models for assessing neurodegenerative phenotypes. Here we describe a high-throughput method to analyze Drosophila adult negative geotaxis behavior, as an indication for possible motor defects associated with neurodegeneration...
September 12, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28930954/acute-procedural-interventions-after-pediatric-blunt-abdominal-trauma-a-prospective-multicenter-evaluation
#19
Chase A Arbra, Adam M Vogel, Jingwen Zhang, Patrick D Mauldin, Eunice Y Huang, Kate B Savoie, Matthew T Santore, KuoJen Tsao, Tiffany G Ostovar-Kermani, Richard A Falcone, M Sidney Dassinger, John Recicar, Jeffrey H Haynes, Martin L Blakely, Robert T Russell, Bindi J Naik-Mathuria, Shawn D St Peter, David P Mooney, Chinwendu Onwubiko, Jeffrey S Upperman, Christian J Streck
BACKGROUND: Pediatric intra-abdominal injuries (IAI) from blunt abdominal trauma (BAT) rarely require emergent intervention. For those children undergoing procedural intervention, our aim was to understand the timing and indications for operation and angiographic embolization. METHODS: We prospectively enrolled children younger than 16 years after BAT at 14 Level I Pediatric Trauma Centers over a 1-year period. Patients with IAI who received an intervention (IAI-I) were compared with those who did not receive an intervention using descriptive statistics and univariate analysis; p less than 0...
October 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28930789/intracranial-penetration-during-temporal-soft-tissue-filler-injection-is-it-possible
#20
Wolfgang G Philipp-Dormston, Lara Bieler, Mathias Hessenberger, Thilo L Schenck, Konstantin Frank, Johann Fierlbeck, Sebastian Cotofana
BACKGROUND: Treating temporal volume loss for aesthetic and reconstructive purposes can be achieved by superficial or deep injections of soft tissue fillers into the temples. The latter is performed with bone contact that can lead to intracranial penetration when the bone is accidentally penetrated. OBJECTIVE: Based on a clinical case, the potential risk of accidental intracranial penetration was investigated. MATERIALS AND METHODS: Twenty fresh-frozen hemi-faces (all Caucasian ethnicity, 10 women, 10 men, mean age 72...
September 19, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
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