keyword
MENU ▼
Read by QxMD icon Read
search

statistical mechanics

keyword
https://www.readbyqxmd.com/read/28550754/linear-polysialoside-outperforms-dendritic-analogs-for-inhibition-of-influenza-virus-infection-in%C3%A2-vitro-and-in%C3%A2-vivo
#1
Sumati Bhatia, Daniel Lauster, Markus Bardua, Kai Ludwig, Stefano Angioletti-Uberti, Nicole Popp, Ute Hoffmann, Florian Paulus, Matthias Budt, Marlena Stadtmüller, Thorsten Wolff, Alf Hamann, Christoph Böttcher, Andreas Herrmann, Rainer Haag
Inhibition of influenza A virus infection by multivalent sialic acid inhibitors preventing viral hemagglutinin binding to host cells of the respiratory tract is a promising strategy. However, optimal geometry and optimal ligand presentation on multivalent scaffolds for efficient inhibition both in vitro and in vivo application are still unclear. Here, by comparing linear and dendritic polyglycerol sialosides (LPGSA and dPGSA) we identified architectural requirements and optimal ligand densities for an efficient multivalent inhibitor of influenza virus A/X31/1 (H3N2)...
May 20, 2017: Biomaterials
https://www.readbyqxmd.com/read/28550663/-sensitivity-of-doxorubicin-resistant-osteosarcoma-cells-to-doxorubicin-regulated-by-long-non-coding-rna-nr_036444
#2
K P Zhu, C L Zhang
Objective: To investigate the mechanism of long non-coding RNA (LncRNA) NR_036444 mediated sensitivity of multidrug-resistant osteosarcoma to doxorubicin. Methods: LncRNA-mRNA combined microarray was used to screen the differential expressions of lncRNA and mRNA in doxorubicin-resistant MG63/DXR osteosarcoma cells and their paired doxorubicin-sensitive MG63 cells; qRT-PCR was used to check the consistency of microarray. LncRNA NR_036444 was over-expressed in MG63/DXR cells by lentrvirus. CCK-8 array was used to evaluate cell proliferation and the sensitivity of cells to doxorubicin; Flow cytometry was used to evaluate cell cycle and apoptosis...
April 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28549769/variations-in-the-cerebrospinal-fluid-proteome-following-traumatic-brain-injury-and-subarachnoid-hemorrhage
#3
David E Connor, Ganta V Chaitanya, Prashant Chittiboina, Paul McCarthy, L Keith Scott, Lisa Schrott, Alireza Minagar, Anil Nanda, J Steven Alexander
BACKGROUND: Proteomic analysis of cerebrospinal fluid (CSF) has shown great promise in identifying potential markers of injury in neurodegenerative diseases [1-13]. Here we compared CSF proteomes in healthy individuals, with patients diagnosed with traumatic brain injury (TBI) and subarachnoid hemorrhage (SAH) in order to characterize molecular biomarkers which might identify these different clinical states and describe different molecular mechanisms active in each disease state. METHODS: Patients presenting to the Neurosurgery service at the Louisiana State University Hospital-Shreveport with an admitting diagnosis of TBI or SAH were prospectively enrolled...
May 13, 2017: Pathophysiology: the Official Journal of the International Society for Pathophysiology
https://www.readbyqxmd.com/read/28549527/vitamin-d-supplementation-in-the-critically-ill-a-systematic-review-and-meta-analysis
#4
Pascal L Langlois, Celeste Szwec, Frédérick D'Aragon, Daren K Heyland, William Manzanares
INTRODUCTION: Vitamin D insufficiency is reported in up to 50% of the critically ill patients and is associated with increased mortality, length of stay (LOS) in intensive care unit (ICU) and hospital, and respiratory disorders with prolonged ventilation. Benefits of vitamin D supplementation remain unclear. The aim of this systematic review was to evaluate the clinical benefits of vitamin D administration in critically ill patients. METHODS: We searched Medline, Embase, CINAHL and Cochrane database for randomized controlled trials (RCT) conducted on heterogeneous ICU patients comparing vitamin D administration to placebo...
May 11, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28549199/effect-of-1-25-oh2d3-on-the-proliferation-of-human-mesangial-cells-and-their-expression-of-ki67
#5
D Zhao, C-J Zhang, R Yang, J-P Chen, L Ma, G Liu, X-P Yang
Previous studies have found that 1,25-dihydroxyvitamin D3 [1,25(OH)2D3 or VD3] exerts many biological effects, including the inhibition of cell proliferation and induction of apoptosis, but its mechanism of action remains unclear. The goal of our investigation was to explore the effects of 1,25(OH)2D3 on the proliferation of cultured human mesangial cells and their expression of Ki67 in vitro, and to establish its mechanism of action. Cultured human mesangial cells were randomly divided into the following four groups: normal control (N group; administered Dulbecco's modified Eagle's medium containing 5% fetal bovine serum), proliferation [epidermal growth factor (EGF) group; administered 10 μg/L EGF], VD3 intervention [administered 10(-8) M 1,25(OH)2D3], and proliferation and intervention [EGF+VD3 group; administered 10 μg/L EGF and 10(-8) M 1,25(OH)2D3]...
May 25, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28548997/anterior-inferior-plating-results-in-fewer-secondary-interventions-compared-to-superior-plating-for-acute-displaced-mid-shaft-clavicle-fracture
#6
Rafael Serrano, Amrut Borade, Hassan Mir, Anjan Shah, David Watson, Anthony Infante, Mark A Frankle, Mark A Mighell, H Claude Sagi, Daniel S Horwitz, Roy W Sanders
OBJECTIVES: To determine if a difference in plate position for fixation of acute, displaced, mid-shaft clavicle fractures would affect the rate of secondary intervention. DESIGN: Retrospective Comparative Study SETTING:: two academic Level 1 Regional Trauma Centers PATIENTS:: 510 patients treated surgically for an acutely displaced mid-shaft clavicle fracture between 2000-2013 were identified and reviewed retrospectively at a minimum of 24 months' follow-up (F/U)...
April 5, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28548569/thyroxine-increases-collagen-type-ii-expression-and-accumulation-in-scaffold-free-tissue-engineered-articular-cartilage
#7
G Adam Whitney, Thomas J Kean, Russell J Fernandes, Stephen D Waldman, M Yat Tse, Stephen C Pang, Joseph M Mansour, James E Dennis
Low collagen accumulation in the extra-cellular matrix is a pressing problem in cartilage tissue engineering, leading to a low collagen-to-glycosaminoglycan (GAG) ratio and poor mechanical properties in neo-cartilage. Soluble factors have been shown to increase collagen content, but may result in a more pronounced increase in GAG content. Thyroid hormones have been reported to stimulate collagen and GAG production, but reported outcomes, including which specific collagen types are affected, are variable throughout the literature...
May 26, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/28548528/typical-relaxation-of-isolated-many-body-systems-which-do-not-thermalize
#8
Ben N Balz, Peter Reimann
We consider isolated many-body quantum systems which do not thermalize; i.e., expectation values approach an (approximately) steady longtime limit which disagrees with the microcanonical prediction of equilibrium statistical mechanics. A general analytical theory is worked out for the typical temporal relaxation behavior in such cases. The main prerequisites are initial conditions which appreciably populate many energy levels and do not give rise to significant spatial inhomogeneities on macroscopic scales...
May 12, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28548507/bloch-waves-in-minimal-landau-gauge-and-the-infinite-volume-limit-of-lattice-gauge-theory
#9
Attilio Cucchieri, Tereza Mendes
By exploiting the similarity between Bloch's theorem for electrons in crystalline solids and the problem of Landau gauge fixing in Yang-Mills theory on a "replicated" lattice, we show that large-volume results can be reproduced by simulations performed on much smaller lattices. This approach, proposed by Zwanziger [Nucl. Phys. B412, 657 (1994)NUPBBO0550-321310.1016/0550-3213(94)90396-4], corresponds to taking the infinite-volume limit for Landau-gauge field configurations in two steps: first for the gauge transformation alone, while keeping the lattice volume finite, and second for the gauge-field configuration itself...
May 12, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28547318/a-systematic-review-of-alpha-2-agonists-for-sedation-in-mechanically-ventilated-neurocritical-care-patients
#10
Alexandre Tran, Henrietta Blinder, Brian Hutton, Shane W English
The use of sedative medications is commonplace in intensive care units (ICUs) and an invaluable clinical tool for the intensive care physician. Sedation for critically ill, mechanically ventilated patients provides an opportunity to reduce anxiety, discomfort as well as ventilator intolerance and dyssynchrony. Alpha-2 agonists in particular have become increasingly popular for use in the neurocritical care population due to their proposed effectiveness in facilitating examinations and procedures as well as reducing the need for adjunctive agents...
May 25, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28545587/type-2-diabetes-and-obesity-induce-similar-transcriptional-reprogramming-in-human-myocytes
#11
Leif Väremo, Tora Ida Henriksen, Camilla Scheele, Christa Broholm, Maria Pedersen, Mathias Uhlén, Bente Klarlund Pedersen, Jens Nielsen
BACKGROUND: Skeletal muscle is one of the primary tissues involved in the development of type 2 diabetes (T2D). The close association between obesity and T2D makes it difficult to isolate specific effects attributed to the disease alone. Therefore, here we set out to identify and characterize intrinsic properties of myocytes, associated independently with T2D or obesity. METHODS: We generated and analyzed RNA-seq data from primary differentiated myotubes from 24 human subjects, using a factorial design (healthy/T2D and non-obese/obese), to determine the influence of each specific factor on genome-wide transcription...
May 25, 2017: Genome Medicine
https://www.readbyqxmd.com/read/28545468/the-contribution-of-the-foreign-population-to-the-high-level-of-infant-mortality-in-switzerland-a-demographic-analysis
#12
Philippe Wanner, Paola Bollini
BACKGROUND: In 2011 Switzerland reported the highest infant mortality rate among Western European countries, as well as the highest percentage of foreign population (23%). The comparison of the Swiss and foreign population in terms of reproductive health has received so far insufficient attention. The aim of the present study is to analyze the infant (IMR) and neonatal mortality rates (NMR) of Swiss and foreign children over the last 30 years. METHODS: Vital statistics from the period 1980 to 2011 were used to compute IMR and NMR according to year and/or citizenship...
May 25, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28545465/an-increase-in-long-non-coding-rna-pandar-is-associated-with-poor-prognosis-in-clear-cell-renal-cell-carcinoma
#13
Yi Xu, Yanyue Tong, Jianyong Zhu, Zhangming Lei, Lijun Wan, Xiuwen Zhu, Feng Ye, Liping Xie
BACKGROUND: Nearly 30% of clear cell renal cell carcinoma (ccRCC) patients present with metastasis at the time of diagnosis, and the prognosis for these patients is poor. Therefore, novel potential prognostic biomarkers and therapeutic targets for ccRCC could be helpful. Emerging evidence indicates that lncRNAs play important roles in cancer tumorigenesis and could be used as potential biomarkers or therapeutic targets. PANDAR (promoter of CDKN1A antisense DNA damage activated RNA) is a relatively novel lncRNA that plays an important role in the development of multiple cancers...
May 25, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28545435/urinary-metabolomics-study-on-the-protective-role-of-orthosiphon-stamineus-in-streptozotocin-induced-diabetes-mellitus-in-rats-via-1-h-nmr-spectroscopy
#14
Amalina Ahmad Azam, Raghunath Pariyani, Intan Safinar Ismail, Amin Ismail, Alfi Khatib, Faridah Abas, Khozirah Shaari
BACKGROUND: Orthosiphon stamineus (OS) is a herb known in ethnomedicine for treating diabetes mellitus (DM). In this study, a (1)H NMR based urine metabolomics tool has been used for the first time to identify the metabolic protective mechanism of OS in DM using Streptozotocin (STZ) induced experimental model in rats. METHODS: Four different solvent extracts of OS, namely aqueous, ethanolic, 50% aqueous ethanolic and methanolic, at a dose of 500 mg/kg body weight (bw) were orally administered for 14 days to diabetic rats induced via intraperitoneal injection of 60 mg/kg bw STZ...
May 25, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28545397/jed-a-java-essential-dynamics-program-for-comparative-analysis-of-protein-trajectories
#15
Charles C David, Ettayapuram Ramaprasad Azhagiya Singam, Donald J Jacobs
BACKGROUND: Essential Dynamics (ED) is a common application of principal component analysis (PCA) to extract biologically relevant motions from atomic trajectories of proteins. Covariance and correlation based PCA are two common approaches to determine PCA modes (eigenvectors) and their eigenvalues. Protein dynamics can be characterized in terms of Cartesian coordinates or internal distance pairs. In understanding protein dynamics, a comparison of trajectories taken from a set of proteins for similarity assessment provides insight into conserved mechanisms...
May 25, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28545187/enterolactone-suppresses-proliferation-migration-and-metastasis-of-mda-mb-231-breast-cancer-cells-through-inhibition-of-upa-induced-plasmin-activation-and-mmps-mediated-ecm-remodeling
#16
Aniket V Mali, Asavari A Joshi, Mahabaleshwar V Hegde, Shivajirao S Kadam
Background: To enhance their own survival, tumor cells can manipulate their microenvironment through remodeling of the extra cellular matrix (ECM). The urokinase-type plasminogen activator (uPA) system catalyzes plasmin production which further mediates activation of matrix metalloproteinases (MMPs) and plays an important role in breast cancer invasion and metastasis through ECM remodeling. This provides a potential target for therapeutic intervention of breast cancer treatment. Enterolactone (EL) is derived from dietary flax lignans in the human body and is known to have anti-breast cancer activity...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28545105/research-on-calibrating-rock-mechanical-parameters-with-a-statistical-method
#17
Zhen Liu, Ye Guo, Shuheng Du, Gengyu Wu, Mao Pan
Research on the modeling of rock mechanics parameters is of great significance to the exploration of oil and gas. The use of logging data with the Kriging interpolation to study rock mechanics parameters has been proven to be effective in reservoir prediction and other oilfield applications and can provide additional data. However, there will sometimes be a great deviation due to the limited samples and the strong heterogeneity of a layer. To solve this problem, a new approach was proposed to calibrate rock mechanical models through the statistical analysis of logging data...
2017: PloS One
https://www.readbyqxmd.com/read/28544519/the-effect-of-helium-oxygen-assisted-mechanical-ventilation-on-chronic-obstructive-pulmonary-disease-exacerbation-a-systemic-review-and-meta-analysis
#18
Xu Wu, Chuan Shao, Liang Zhang, Jinjing Tu, Hui Xu, Zhihui Lin, Shuguang Xu, Biyun Yu, Yaodong Tang, Shanqun Li
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is often accompanied by acute exacerbations. Patients of COPD exacerbation suffering from respiratory failure often need the support of mechanical ventilation. Helium-oxygen can be used to reduce airway resistance during mechanical ventilation. The aim of this study is to evaluate the effect of helium-oxygen-assisted mechanical ventilation on COPD exacerbation through a meta-analysis. METHODS: A comprehensive literature search through databases of Pub Med (1966∼2016), Ovid MEDLINE (1965∼2016), Cochrane EBM (1991∼2016), EMBASE (1974∼2016) and Ovid MEDLINE was performed to identify associated studies...
May 24, 2017: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28544421/japan-s-115-year-trend-of-inter-prefectural-disparities-in-under-five-mortality
#19
Chie Nagata, Akinori Moriichi, Naho Morisaki, Ruoyan Gai-Tobe, Akira Ishiguro, Rintaro Mori
BACKGROUND: Child poverty is a growing, serious issue in Japan, where various social disparities are widening. Numerous reports have focused on the relationship between social inequity and health. However, few studies have assessed how the overall magnitude of disparities in child health has changed over the course of drastic social and economic transitions from 1899 to more recent times. In this study, we assessed the trend of the under-five mortality rate (U5MR) and its inter-prefectural disparities in Japan...
May 23, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28544415/inertial-microfluidic-cell-stretcher-imcs-fully-automated-high-throughput-and-near-real-time-cell-mechanotyping
#20
Yanxiang Deng, Steven P Davis, Fan Yang, Kevin S Paulsen, Maneesh Kumar, Rebecca Sinnott DeVaux, Xianhui Wang, Douglas S Conklin, Assad Oberai, Jason I Herschkowitz, Aram J Chung
Mechanical biomarkers associated with cytoskeletal structures have been reported as powerful label-free cell state identifiers. In order to measure cell mechanical properties, traditional biophysical (e.g., atomic force microscopy, micropipette aspiration, optical stretchers) and microfluidic approaches were mainly employed; however, they critically suffer from low-throughput, low-sensitivity, and/or time-consuming and labor-intensive processes, not allowing techniques to be practically used for cell biology research applications...
May 23, 2017: Small
keyword
keyword
64894
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"