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https://www.readbyqxmd.com/read/28719813/comparative-stability-indicating-chromatographic-methods-for-determination-of-4-hexylresorcinol-in-pharmaceutical-formulation-and-shrimps
#1
Rafeek F Shokry, Lories I Bebawy, Mohamed R Elghobashy, Samah S Abbas
Three chromatographic stability-indicating methods were developed for determination of 4-hexylresorcinol in pure form and in a pharmaceutical formulation. Method A was based on a gradient elution liquid chromatographic HPLC determination of 4-hexylresorcinol, its related impurities and in presence of its degradation products. UPLC-MS/MS (Method B) was described for determination of the cited drug in presence of its degradation products. Method C was a thin- layer chromatography (TLC)-densitometry method for the separation and determination of the active ingredient, one of its related impurities and in presence of its degradation products...
July 8, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28718873/clinical-features-of-drug-reaction-with-eosinophilia-and-systemic-symptoms-dress-syndrome-a-study-of-25-patients-in-korea
#2
Jin Y Lee, Suh-Young Lee, Ji E Hahm, Jae W Ha, Chul W Kim, Sang S Kim
BACKGROUND: Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare adverse drug reaction. This study aimed to evaluate the incidence of association with individual drugs, clinical manifestations, disease course, and outcomes of DRESS. METHODS: Using the criteria of the European Registry of Severe Cutaneous Adverse Reactions (RegiSCAR), the medical records of 25 patients diagnosed with DRESS between 2006 and 2015 were retrospectively reviewed...
July 18, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28718012/implant-decontamination-with-phosphoric-acid-during-surgical-peri-implantitis-treatment-a-rct
#3
Diederik F M Hentenaar, Yvonne C M De Waal, Hans Strooker, Henny J A Meijer, Arie-Jan Van Winkelhoff, Gerry M Raghoebar
BACKGROUND: Peri-implantitis is known as an infectious disease that affects the peri-implant soft and hard tissue. Today, scientific literature provides very little evidence for an effective intervention protocol for treatment of peri-implantitis. The aim of the present randomized controlled trial is to evaluate the microbiological and clinical effectiveness of phosphoric acid as a decontaminating agent of the implant surface during surgical peri-implantitis treatment. METHODS: Peri-implantitis lesions were treated with resective surgical treatment aimed at peri-implant granulation tissue removal, bone recontouring, and pocket elimination...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28717537/paraoxonase-and-arylesterase-activity-in-bladder-cancer
#4
Mehmet Mazhar Utanğaç, Ercan Yeni, Murat Savaş, Adem Altunkol, Halil Çiftçi, Kemal Gümüş, Mehmet Demir
OBJECTIVE: Oxidative stress is the main pathogenetic mechanism in bladder cancer among many other causes. We aimed to investigate whether a potential relationship exists between bladder cancer and the activities of paraoxonase (PON1) and arylesterase (ARE) enzymes. MATERIAL AND METHODS: The study included 56 patients with bladder cancer, and 57 healthy individuals. The relationships between enzyme activity and tumour grade, stage, muscular invasion and tumour size were evaluated...
June 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28717534/effect-of-low-energy-shockwave-therapy-on-angiogenic-factors-in-the-penile-tissue-of-diabetic-rats
#5
Mazhar Ortaç, Canan Küçükergin, Emre Salabaş, Şule Seçkin, Ateş Kadıoğlu
OBJECTIVE: The aim of this study is to investigate the effect of low-energy shock wave therapy (LESWT) on angiogenesis factors at penile tissue in a diabetic rat model. MATERIAL AND METHODS: A total of 30 male Sprague-Dawley rats which were allocated into three equal groups were included study. Group 1 (control group) included 10 male rats which did not receive any treatment were randomly chosen to serve as normal control. The remaining rats were injected intraperitoneally with 60 mg/kg of streptozotocin (STZ) to induce diabetes...
June 2017: Turkish Journal of Urology
https://www.readbyqxmd.com/read/28717101/mechanism-based-risk-assessment-strategy-for-drug-induced-cholestasis-using-the-transcriptional-benchmark-dose-derived-by-toxicogenomics
#6
Taisuke Kawamoto, Yuichi Ito, Osamu Morita, Hiroshi Honda
Cholestasis is one of the major causes of drug-induced liver injury (DILI), which can result in withdrawal of approved drugs from the market. Early identification of cholestatic drugs is difficult due to the complex mechanisms involved. In order to develop a strategy for mechanism-based risk assessment of cholestatic drugs, we analyzed gene expression data obtained from the livers of rats that had been orally administered with 12 known cholestatic compounds repeatedly for 28 days at three dose levels. Qualitative analyses were performed using two statistical approaches (hierarchical clustering and principle component analysis), in addition to pathway analysis...
2017: Journal of Toxicological Sciences
https://www.readbyqxmd.com/read/28716931/combining-experimental-and-simulation-data-of-molecular-processes-via-augmented-markov-models
#7
Simon Olsson, Hao Wu, Fabian Paul, Cecilia Clementi, Frank Noé
Accurate mechanistic description of structural changes in biomolecules is an increasingly important topic in structural and chemical biology. Markov models have emerged as a powerful way to approximate the molecular kinetics of large biomolecules while keeping full structural resolution in a divide-and-conquer fashion. However, the accuracy of these models is limited by that of the force fields used to generate the underlying molecular dynamics (MD) simulation data. Whereas the quality of classical MD force fields has improved significantly in recent years, remaining errors in the Boltzmann weights are still on the order of a few [Formula: see text], which may lead to significant discrepancies when comparing to experimentally measured rates or state populations...
July 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28716697/copy-number-variations-of-the-il-22-gene-are-associated-with-ankylosing-spondylitis-a-case-control-study-in-chinese-han-population
#8
Xu Zhang, Xiaona Li, Renfang Han, Mengya Chen, Yaping Yuan, Xingxing Hu, Mengmeng Wang, Rui Li, Xiao Yang, Qing Xia, Yubo Ma, Jiajia Yang, Jingjing Tong, Shengqian Xu, Jianhua Xu, Zongwen Shuai, Faming Pan
IL-22 provides a new insight into the mechanisms of autoimmunity, and copy number variations (CNVs) are associated with autoimmune diseases. This study aims to explore the association of IL-22 gene CNVs with ankylosing spondylitis (AS) susceptibility. The copy numbers of IL-22 gene (2 fragments: IL-22_1, IL-22_2) were examined by AccuCopy(TM) methods in a cohort of 649 AS patients and 628 controls. Association of IL-22 CNVs and AS susceptibility was analyzed, and AS risk was estimated by Odds Ratio (ORs) and 95% confidence intervals (CIs), and the Benjamini-Hochberg method was applied to regulate the false discovery rate (FDR)...
July 14, 2017: Human Immunology
https://www.readbyqxmd.com/read/28716473/characteristics-of-mandibular-injuries-caused-by-bullets-and-improvised-explosive-devices-a-comparative-study
#9
S Y H Bede, W K Ismael, D Al-Assaf
The purpose of this study was to investigate the difference in mandibular trauma caused by two mechanisms for the delivery of missile injuries: firearms and improvised explosive devices (IEDs). The data investigated included sex, age, mechanism of injury, and other clinical and radiographic manifestations. Seventy consecutive patients, predominantly male, with a mean age of 28.6±14 years (range 2-60 years) were enrolled: 38 patients (54.3%) sustained mandibular fractures caused by bullet injuries and 32 patients (45...
July 14, 2017: International Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28716210/exploring-injury-severity-measures-and-in-hospital-mortality-a-multi-hospital-study-in-kenya
#10
Yuen W Hung, Huan He, Amber Mehmood, Isaac Botchey, Hassan Saidi, Adnan A Hyder, Abdulgafoor M Bachani
INTRODUCTION: Low- and middle-income countries (LMICs) have a disproportionately high burden of injuries. Most injury severity measures were developed in high-income settings and there have been limited studies on their application and validity in low-resource settings. In this study, we compared the performance of seven injury severity measures: estimated Injury Severity Score (eISS), Glasgow Coma Score (GCS), Mechanism, GCS, Age, Pressure score (MGAP), GCS, Age, Pressure score (GAP), Revised Trauma Score (RTS), Trauma and Injury Severity Score (TRISS) and Kampala Trauma Score (KTS), in predicting in-hospital mortality in a multi-hospital cohort of adult patients in Kenya...
July 8, 2017: Injury
https://www.readbyqxmd.com/read/28715816/distinct-dynamics-of-mitotic-transition-in-b-cell-lymphoma-and-reactive-b-cell-lymphoproliferations-determined-by-h3s10-phosphohistone-immunolabeling
#11
Gábor Méhes, Katalin Hegyi, Ravi Jobanputra, Lívia Beke, György Vereb, Judit Bedekovics
OBJECTIVES: Clonal selection in the follicular germinal centers in lymphatic tissues is accompanied by an intense proliferation of polyclonal B cells in a precisely regulated fashion. In contrast, B-cell neoplasias proliferate autonomously due to endogenous stimuli. The cell kinetic activity is obvious at many levels including progressive chromatin modification and elevated mitotic rates. We asked if there are differences in the kinetics of histone H3S10 phosphorylation required for mitotic entry between highly proliferating B cells of reactive germinal centers and in B-cell lymphomas with different proliferative capacity...
July 18, 2017: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/28715787/micronutrients-during-pregnancy-and-child-psychomotor-development-opposite-effects-of-zinc-and-selenium
#12
Kinga Polanska, Wojciech Hanke, Anna Krol, Jolanta Gromadzinska, Renata Kuras, Beata Janasik, Wojciech Wasowicz, Fiorino Mirabella, Flavia Chiarotti, Gemma Calamandrei
Studies on the impact of micronutrient levels during different pregnancy periods on child psychomotor functions are limited. The aim of this study was to evaluate the association between maternal plasma concentrations of selected micronutrients, such as: copper (Cu), zinc (Zn), selenium (Se), and child neuropsychological development. The study population consisted of 539 mother-child pairs from Polish Mother and Child Cohort (REPRO_PL). The micronutrient levels were measured in each trimester of pregnancy, at delivery and in the cord blood...
July 14, 2017: Environmental Research
https://www.readbyqxmd.com/read/28715745/a-practical-protocol-for-comprehensive-evaluation-of-sulfur-fumigation-of-gastrodia-rhizoma-using-metabolome-and-health-risk-assessment-analysis
#13
Chuanzhi Kang, Chang-Jiang-Sheng Lai, Dan Zhao, Tao Zhou, Da-Hui Liu, Chaogeng Lv, Sheng Wang, Liping Kang, Jian Yang, Zhi-Lai Zhan, Lu-Qi Huang, Lanping Guo
Gastrodia Rhizoma is one of the most heavily sulfur-fumigated edible and medical herbs in the marketplace. We developed a practical protocol using an ultra-performance liquid chromatography coupled with quadrupole time-of-flight-MS(E) (UPLC/QTOF-MS(E))-based metabolome and health risk assessment model to identify characteristic sulfur-fumigated markers, dissect chemical transformation mechanisms, and control the quality of sulfur-fumigated Gastrodia Rhizoma. Two sulfur-containing p-hydroxybenzyl products, one sulfur-containing disaccharide, one glycolipid, and two phospholipids were selected and identified as markers based on multivariate statistical analysis...
July 4, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28715675/resting-state-brain-networks-in-patients-with-parkinson-s-disease-and-impulse-control-disorders
#14
Alessandro Tessitore, Gabriella Santangelo, Rosa De Micco, Alfonso Giordano, Simona Raimo, Marianna Amboni, Fabrizio Esposito, Paolo Barone, Gioacchino Tedeschi, Carmine Vitale
INTRODUCTION: To investigate intrinsic neural networks connectivity changes in Parkinson's disease (PD) patients with and without impulse control disorders (ICD). METHODS: Fifteen patients with PD with ICD (ICD+), 15 patients with PD without ICD (ICD-) and 24 age and sex-matched healthy controls (HC) were enrolled in the study. To identify patients with and without ICD and/or punding, we used the Minnesota Impulsive Disorders Interview (MIDI) and a clinical interview based on diagnostic criteria for each symptom...
June 24, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28715635/redox-potentials-from-ab-initio-molecular-dynamics-and-explicit-entropy-calculations-application-to-transition-metals-in-aqueous-solution
#15
Miguel A Caro, Olga Lopez-Acevedo, Tomi Laurila
We present a complete methodology to consistently estimate redox potentials strictly from first principles, without any experimental input. The methodology is based on (i) ab initio molecular dynamics (MD) simulations, (ii) all-atom explicit solvation, (iii) the two-phase thermodynamic (2PT) model and (iv) the use of electrostatic potentials as references for the absolute electrochemical scale. We apply the approach presented to compute reduction potentials of the following redox couples: Cr(+2/+3), V(+2/+3), Ru(NH3)6(+2/+3), Sn(+2/+4), Cu(+1/+2), FcMeOH(0/+1) and Fe(+2/+3) (in aqueous solution) and Fc(0/+1) (in acetonitrile)...
July 17, 2017: Journal of Chemical Theory and Computation
https://www.readbyqxmd.com/read/28715507/independent-component-analysis-ica-based-clustering-of-temporal-rna-seq-data
#16
Moysés Nascimento, Fabyano Fonseca E Silva, Thelma Sáfadi, Ana Carolina Campana Nascimento, Talles Eduardo Maciel Ferreira, Laís Mayara Azevedo Barroso, Camila Ferreira Azevedo, Simone Eliza Faccione Guimarães, Nick Vergara Lopes Serão
Gene expression time series (GETS) analysis aims to characterize sets of genes according to their longitudinal patterns of expression. Due to the large number of genes evaluated in GETS analysis, an useful strategy to summarize biological functional processes and regulatory mechanisms is through clustering of genes that present similar expression pattern over time. Traditional cluster methods usually ignore the challenges in GETS, such as the lack of data normality and small number of temporal observations...
2017: PloS One
https://www.readbyqxmd.com/read/28715325/inference-based-similarity-search-in-randomized-montgomery-domains-for-privacy-preserving-biometric-identification
#17
Yi Wang, Jianwu Wan, Jun Guo, Yiu-Ming Cheung, Pong C Yuen
Similarity search is essential to many important applications and often involves searching at scale on high-dimensional data based on their similarity to a query. In biometric applications, recent vulnerability studies have shown that adversarial machine learning can compromise biometric recognition systems by exploiting the biometric similarity information. Existing methods for biometric privacy protection are in general based on pairwise matching of secured biometric templates and have inherent limitations in search efficiency and scalability...
July 14, 2017: IEEE Transactions on Pattern Analysis and Machine Intelligence
https://www.readbyqxmd.com/read/28715019/thermodynamic-integration-network-study-of-electron-transfer-from-proteins-to-aggregates
#18
Sehee Na, Anna Bauß, Michael Langenmaier, Thorsten Koslowski
We describe electron transfer through the NrfHA nitrite reductase heterodimer using a thermodynamic integration scheme based upon molecular dynamics simulations. From the simulation data, we estimate two of the characteristic energies of electron transfer, the thermodynamic driving forces, ΔG, and the reorganization energies, λ. Using a thermodynamic network analysis, the statistical accuracy of the ΔG values can be enhanced significantly. Although the reaction free energies and activation barriers are hardly affected by protein aggregation, the complete reaction mechanism only emerges from the simulations of the dimer rather than focussing on the individual protein chains: it involves an equienergetic transprotein element of electron storage and conductivity...
July 17, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28714783/performance-outcomes-after-hook-of-hamate-fractures-in-major-league-baseball-players
#19
Michael S Guss, John P Begly, Austin J Ramme, David P Taormina, Michael E Rettig, John T Capo
CONTEXT: Major League Baseball (MLB) players are at risk of hook of hamate fractures. There is a paucity of data assessing the effect of a hook of hamate fracture on MLB players' future athletic performance. OBJECTIVE: To determine if MLB players who sustain hook of hamate fractures demonstrate decreased performance upon return to competition when compared with their performance before injury and that of their control-matched peers. DESIGN: Retrospective Case-Control Design...
July 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28714731/falsifiability-is-not-optional
#20
Etienne P LeBel, Derek Berger, Lorne Campbell, Timothy J Loving
Finkel, Eastwick, and Reis (2016; FER2016) argued the post-2011 methodological reform movement has focused narrowly on replicability, neglecting other essential goals of research. We agree multiple scientific goals are essential, but argue, however, a more fine-grained language, conceptualization, and approach to replication is needed to accomplish these goals. Replication is the general empirical mechanism for testing and falsifying theory. Sufficiently methodologically similar replications, also known as direct replications, test the basic existence of phenomena and ensure cumulative progress is possible a priori...
August 2017: Journal of Personality and Social Psychology
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