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https://www.readbyqxmd.com/read/28108684/ability-of-icu-health-care-professionals-to-identify-patient-ventilator-asynchrony-using-waveform-analysis
#1
Ivan I Ramirez, Daniel H Arellano, Rodrigo S Adasme, Jose M Landeros, Francisco A Salinas, Alvaro G Vargas, Francisco J Vasquez, Ignacio A Lobos, Magdalena L Oyarzun, Ruben D Restrepo
BACKGROUND: Waveform analysis by visual inspection can be a reliable, noninvasive, and useful tool for detecting patient-ventilator asynchrony. However, it is a skill that requires a properly trained professional. METHODS: This observational study was conducted in 17 urban ICUs. Health-care professionals (HCPs) working in these ICUs were asked to recognize different types of asynchrony shown in 3 evaluation videos. The health-care professionals were categorized according to years of experience, prior training in mechanical ventilation, profession, and number of asynchronies identified correctly...
February 2017: Respiratory Care
https://www.readbyqxmd.com/read/28108552/predicted-residual-error-sum-of-squares-of-mixed-models-an-application-to-genomic-prediction
#2
Shizhong Xu
Genomic prediction is a statistical method to predict phenotypes of polygenic traits using high throughput genomic data. Most diseases and behaviors in human and animals are polygenic traits. The majority of agronomic traits in crops are also polygenic. Accurate prediction of these traits can help medical professionals diagnose acute diseases and breeders to increase food products, and therefore, significantly contribute to human health and global food security. The best linear unbiased prediction (BLUP) is an important tool to analyze high throughput genomic data for prediction...
January 20, 2017: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/28108423/isolated-transverse-process-fractures-a-systematic-analysis
#3
REVIEW
Daniel T Nagasawa, Timothy T Bui, Carlito Lagman, Seung J Lee, Lawrance K Chung, Tianyi Niu, Alexander Tucker, Bilwaj Gaonkar, Isaac Yang, Luke Macyszyn
OBJECTIVE: To review the literature on isolated transverse process fractures (ITPFs) and provide evidence for and validate the current practice of conservative management. METHODS: The PubMed database was searched for published literature related to ITPFs. Baseline patient (age, sex, presentation, mechanism of injury) and fracture (number of fractures, level, single or multi-segmental) characteristics were extracted. Management, and outcomes were also recorded. Statistical comparisons were ascertained through N-1 Pearson Chi-squared tests...
January 17, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28108167/posterior-cruciate-retaining-versus-posterior-stabilized-total-knee-arthroplasty-for-osteoarthritis-with-severe-varus-deformity
#4
Ethem Ayhan Ünkar, Yusuf Öztürkmen, Erhan Şükür, Engin Çarkçı, Murat Mert
OBJECTIVE: The aim of this study was to compare the radiological and functional results of posterior cruciate ligament (PCL) - retaining and posterior-stabilized total knee arthroplasties in patients with severe varus gonarthrosis. METHODS: Medical records of 112 knees of 96 patients who underwent total knee arthroplasty for severe varus (≥15°) were reviewed. PCL-retaining and PCL-stabilizing groups consisted of 58 and 54 knees, respectively. Mean follow-up time was 56...
January 17, 2017: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/28108017/influence-of-kinematics-on-the-wear-of-a-total-ankle-replacement
#5
Alexandra Smyth, John Fisher, Silvia Suñer, Claire Brockett
Total ankle replacement (TAR) is an alternative to fusion, replacing the degenerated joint with a mechanical motion-preserving alternative. Minimal pre-clinical testing has been reported to date and existing wear testing standards lack definition. Ankle gait is complex, therefore the aim of this study was to investigate the effect on wear of a range of different ankle gait kinematic inputs. Five Zenith (Corin Group) TARs were tested in a modified knee simulator for twelve million cycles (Mc). Different combinations of IR rotation and AP displacement were applied every 2Mc to understand the effects of the individual kinematics...
January 8, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28107895/psychological-distress-longitudinally-mediates-the-effect-of-vertigo-symptoms-on-vertigo-related-handicap
#6
Thomas Probst, Andreas Dinkel, Gabriele Schmid-Mühlbauer, Katharina Radziej, Karina Limburg, Christoph Pieh, Claas Lahmann
OBJECTIVE: Vertigo symptoms can lead to more or less vertigo-related handicap. This longitudinal study investigated whether depression, anxiety, and/or somatization mediate the relationship between vertigo symptoms and vertigo-related handicap. METHODS: N=111 patients with vertigo/dizziness provided complete data on the following measures: Vertigo symptoms at baseline, depression at 6-month follow-up, anxiety at 6-month follow-up, somatization at 6-month follow-up, and vertigo handicap at 12-month follow-up...
February 2017: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/28107674/mitochondrial-serine-hydroxymethyltransferase-2-is-a-potential-diagnostic-and-prognostic-biomarker-for-human-glioma
#7
Bo Wang, Wei Wang, ZhiZhong Zhu, XueBin Zhang, Fan Tang, Dong Wang, Xi Liu, XiaoLing Yan, Hao Zhuang
OBJECTIVE: Scholars have gradually come to appreciate the relevance of serine and glycine metabolism. Recently, researchers have discovered that mitochondrial serine hydroxymethyltransferase 2 (SHMT2) is overexpressed in various types of cancer. However, the function of SHMT2 in glioma is not clear. In this study, we sought to examine the expression of SHMT2 in glioma, the association between SHMT2 expression and clinicopathological characteristics, and the association of SHMT2 expression with prognosis in glioma patients...
January 16, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28107637/survival-predictions-of-ceramic-crowns-using-statistical-fracture-mechanics
#8
S Nasrin, N Katsube, R R Seghi, S I Rokhlin
This work establishes a survival probability methodology for interface-initiated fatigue failures of monolithic ceramic crowns under simulated masticatory loading. A complete 3-dimensional (3D) finite element analysis model of a minimally reduced molar crown was developed using commercially available hardware and software. Estimates of material surface flaw distributions and fatigue parameters for 3 reinforced glass-ceramics (fluormica [FM], leucite [LR], and lithium disilicate [LD]) and a dense sintered yttrium-stabilized zirconia (YZ) were obtained from the literature and incorporated into the model...
January 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28106849/a-reinforcement-learning-model-equipped-with-sensors-for-generating-perception-patterns-implementation-of-a-simulated-air-navigation-system-using-ads-b-automatic-dependent-surveillance-broadcast-technology
#9
Santiago Álvarez de Toledo, Aurea Anguera, José M Barreiro, Juan A Lara, David Lizcano
Over the last few decades, a number of reinforcement learning techniques have emerged, and different reinforcement learning-based applications have proliferated. However, such techniques tend to specialize in a particular field. This is an obstacle to their generalization and extrapolation to other areas. Besides, neither the reward-punishment (r-p) learning process nor the convergence of results is fast and efficient enough. To address these obstacles, this research proposes a general reinforcement learning model...
January 19, 2017: Sensors
https://www.readbyqxmd.com/read/28105957/identification-of-nuclear-genes-controlling-chlorophyll-synthesis-in%C3%A2-barley-by-rna-seq
#10
Nickolay A Shmakov, Gennadiy V Vasiliev, Natalya V Shatskaya, Alexey V Doroshkov, Elena I Gordeeva, Dmitry A Afonnikov, Elena K Khlestkina
BACKGROUND: Albinism in plants is characterized by lack of chlorophyll and results in photosynthesis impairment, abnormal plant development and premature death. These abnormalities are frequently encountered in interspecific crosses and tissue culture experiments. Analysis of albino mutant phenotypes with full or partial chlorophyll deficiency can shed light on genetic determinants and molecular mechanisms of albinism. Here we report analysis of RNA-seq transcription profiling of barley (Hordeum vulgare L...
November 16, 2016: BMC Plant Biology
https://www.readbyqxmd.com/read/28105928/computer-aided-identification-of-a-hevein-like-antimicrobial-peptide-of-bell-pepper-leaves-for-biotechnological-use
#11
Patrícia Dias Games, Elói Quintas Gonçalves daSilva, Meire de Oliveira Barbosa, Hebréia Oliveira Almeida-Souza, Patrícia Pereira Fontes, Marcos Jorge deMagalhães-Jr, Paulo Roberto Gomes Pereira, Maura Vianna Prates, Gloria Regina Franco, Alessandra Faria-Campos, Sérgio Vale Aguiar Campos, Maria Cristina Baracat-Pereira
BACKGROUND: Antimicrobial peptides from plants present mechanisms of action that are different from those of conventional defense agents. They are under-explored but have a potential as commercial antimicrobials. Bell pepper leaves ('Magali R') are discarded after harvesting the fruit and are sources of bioactive peptides. This work reports the isolation by peptidomics tools, and the identification and partially characterization by computational tools of an antimicrobial peptide from bell pepper leaves, and evidences the usefulness of records and the in silico analysis for the study of plant peptides aiming biotechnological uses...
December 15, 2016: BMC Genomics
https://www.readbyqxmd.com/read/28104468/composite-material-consisting-of-microporous-%C3%AE-tcp-ceramic-and-alginate-for-delayed-release-of-antibiotics
#12
Michael Seidenstuecker, Juergen Ruehe, Norbert P Suedkamp, Annerose Serr, Annette Wittmer, Marc Bohner, Anke Bernstein, Hermann O Mayr
OBJECTIVE: The aim of this study was to produce a novel composite of microporous β-TCP filled with alginate and Vancomycin (VAN) to prolong the release behavior of the antibiotic for up to 28 days. MATERIAL AND METHODS: Using the flow chamber developed by the group, porous ceramics in a directional flow were filled with alginates of different composition containing 50 mg/mL of antibiotics. After cross-linking the alginate with calcium ions, incubation took place in 10 mL double-distilled water for 4 weeks at 37 °C...
January 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28104253/the-effect-of-fampridine-sr-on-cognitive-fatigue-in-a-randomized-double-blind-crossover-trial-in-patients-with-ms
#13
Sarah A Morrow, Heather Rosehart, Andrew M Johnson
BACKGROUND: Cognitive fatigue (CF) is a common complaint in persons with MS (PwMS). Fampridine-SR improves ambulation, fatigue and endurance, due to enhancing action potential formation by blocking potassium channels in demyelinated axons. Thus, through this same mechanism, it is hypothesized that Fampridine-SR could improve CF. OBJECTIVE: To determine if Fampridine-SR objectively improves CF in PwMS. METHODS: Sixty PwMS of any type with CF, defined as 3 or less correct responses when comparing the last third to the first third on the Paced Auditory Serial Addition Test (PASAT), were recruited from a tertiary care MS clinic in London (ON) Canada...
January 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28104027/-inhibition-of-g9a-attenuates-cell-proliferation-via-the-mitochondrial-apoptosis-pathway-in-lung-adenocarcinoma
#14
H J Wan, W Lyu, L Yu, Z Y Zhou, Y J Hu, J Hu
Objective: The aim of this study is to investigate the effect of G9a inhibitor BIX-01294 on attenuating cell proliferation in human lung adenocarcinoma A549 cell line and the underlying molecular mechanism. Methods: Treated with BIX-01294, the growth and proliferation of A549 cells were detected by MTT assay and colony formation assay, and its impact on cell apoptosis was analyzed using flow cytometry. By Western blot, we explored the alterations in the expression of apoptosis-related proteins and the G9a catalysate, H3K9me and H3K9me2...
January 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28104026/-function-and-mechanism-of-zinc-finger-protein-znf50-in-inhibiting-the-growth-of-esophageal-squamous-cell-carcinoma-cells
#15
J Wang, Y H Bi, J Yang, F Liu, Y K Li, H Y Cui, F Wang, J Liu, B Yang, L Zhang
Objective: To investigate the function and mechanism of zinc finger protein 750 (ZNF750) in esophageal squamous cell carcinoma (ESCC). Methods: Xenograft in nude mice was applied to detect the tumorigenesis of ZNF750-depleted ESCC cells. Western blot was performed to observe the expression of downstream target protein of ZNF750 in ESCC cell lines and xenograft tumor tissues in which ZNF750 was knocked down. 3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl-2H tetrazolium bromide (MTT) assay was used to determine the proliferation of ZNF750 stably depleted cells after restoration of its target protein...
January 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28103780/a-random-forest-induced-distance-based-measure-of-physiological-dysregulation
#16
Ghalib Ayodeji Bello, Gerard Dumancas
Aging involves gradual, multisystemic physiological dysregulation and over time, this degenerative process increases an individual's risk for multiple age-related comorbidities. The ability to quantify age-related physiological dysregulation can provide key insights into the biological mechanisms underlying the aging process and facilitate the development of clinical interventions. Recent studies have introduced and validated a measure of physiological dysregulation based on statistical distance. This measure quantifies the extent of physiological dysregulation in an individual by measuring how much the individual's biomarker profile deviates from the expected average...
January 17, 2017: Current Aging Science
https://www.readbyqxmd.com/read/28102428/plasma-adamts13-activity-and-von-willebrand-factor-antigen-and-activity-in-patients-with-subarachnoid-haemorrhage
#17
Monisha Kumar, Wenjing Cao, Jenny K McDaniel, Huy P Pham, Dheeraj Raju, Kelsey Nawalinski, Suzanne Frangos, David Kung, Eric Zager, Scott E Kasner, Joshua M Levine, X Long Zheng
Increased von Willebrand factor (VWF) and reduced ADAMTS13 activity are associated with arterial thrombosis. This may also be the culprit mechanism implicated in delayed cerebral ischaemia after aneurysmal subarachnoid haemorrhage (SAH). It was our objective to determine plasma VWF and ADAMTS13 in patients with SAH and healthy subjects; and to explore the levels of those markers and outcome after SAH. Forty consecutive patients were enrolled between September 2007 and April 2014 in a pilot study. Plasma samples were collected from SAH patients on post-bleed day (PBD) 0, 1, 3, 5, 7 and 10 and healthy controls...
January 19, 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/28102416/phase-separation-in-driven-granular-gases-exploring-the-elusive-character-of-nonequilibrium-steady-states
#18
S Herminghaus, M G Mazza
The emergence of patterns and phase separation in many-body systems far from thermal equilibrium is discussed using the example of driven granular gases. It is shown that phase separation follows a similar mechanism as in the systems of active Brownian particles. Depending on the quantities chosen for observation, it may or may not be easy to find functionals analogous to the free energy in equilibrium statistical physics. We argue that although such functionals can always be derived from the dynamics, it is of only limited value for predicting relevant aspects of the nonequilibrium steady state of the system...
January 19, 2017: Soft Matter
https://www.readbyqxmd.com/read/28101364/hemodynamic-effects-of-electrical-muscle-stimulation-in-the-prophylaxis-of-deep-vein-thrombosis-for-intensive-care-unit-patients-a-randomized-trial
#19
Masahiro Ojima, Ryosuke Takegawa, Tomoya Hirose, Mitsuo Ohnishi, Tadahiko Shiozaki, Takeshi Shimazu
BACKGROUND: Deep vein thrombosis (DVT) is a major complication in critical care. There are various methods of prophylaxis, but none of them fully prevent DVT, and each method has adverse effects. Electrical muscle stimulation (EMS) could be a new effective approach to prevent DVT in intensive care unit (ICU) patients. We hypothesized that EMS increases the venous flow of the lower limbs and has a prophylactic effect against the formation of DVT. METHODS: This study included 26 patients admitted to a single ICU...
2017: Journal of Intensive Care
https://www.readbyqxmd.com/read/28101222/frat1-expression-regulates-proliferation-in-colon-cancer-cells
#20
Kongxi Zhu, Jianqiang Guo, Hongjuan Wang, Weihua Yu
Colorectal cancer is one of the most common gastric malignancies worldwide. However, the underlying mechanism of colon cancer development and valuable indicators of the disease remain unclear. In this study, the expression of frequently rearranged in advanced T-cell lymphomas 1 (FRAT1) in colon cancer was investigated and the association between FRAT1 expression and biological properties of tumors was analyzed. A total of 147 colon cancer tissue samples and adjacent normal tissues were collected between January 2013 and June 2014...
December 2016: Oncology Letters
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