Ollavo Nogueira Tozzi, Isabella Gizzi Jiacomini, Thaís Sibioni Berti Bastos, Laura Helena Cherem Netto Nicolazzi, Rebeca Bosso Dos Santos Luz, Laís Cavalieri Paredes, Luis Eduardo Gonçalves, Murilo Henrique Saturnino Lima, Waldiceu A Verri, Niels Olsen Saraiva Camara, Helena Cristina Silva de Assis, Marisa Fernandes de Castilho, Larissa Magalhaes Alvarenga, Tárcio Teodoro Braga
The zebrafish is an animal model of increasing use in many biomedical fields of study, including toxicology, inflammation, and tissue regeneration. In this paper, we have investigated the inflammatory effects of Loxosceles intermedia' s venom (LIV) on zebrafish, as well as the effects of Maresin 2 (Mar2) and Resolvin D5 (RvD5), two specialized pro-resolving mediators (SPMs), in the context of tissue regeneration after fin fold amputation. Furthermore, increasing concentrations of LIV (250-2000 ng) were assayed for their haemolytic effects in vitro, and, afterwards, the same concentrations were evaluated in vivo, when injected intraperitoneally...
2022: Toxicology Reports