keyword
https://read.qxmd.com/read/38388430/ubiquitin-specific-protease-14-targets-pfkl-mediated-glycolysis-to-promote-the-proliferation-and-migration-of-oral-squamous-cell-carcinoma
#21
JOURNAL ARTICLE
Xingming Zhang, Lou Geng, Yi Tang, Yingying Wang, Youping Zhang, Chujiao Zhu, Hu Lei, Hanzhang Xu, Qi Zhu, Yingli Wu, Wenli Gu
Aberrant upregulation of the ubiquitin-specific protease 14 (USP14) has been found in some malignant tumors, including oral squamous cell carcinoma (OSCC). In this study, we further demonstrated that aberrantly overexpressed USP14 was also closely related to adverse clinicopathological features and poor prognosis in patients with OSCC, so we hypothesized that USP14 might act as a tumor-promoting factor during the progression of OSCC. Notably, we originally proved that USP14 is a deubiquitinating enzyme for phosphofructokinase-1 liver type (PFKL), a key rate-limiting enzyme involved in the glycolytic pathway...
February 22, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38381654/advanced-parkinson-s-disease-treatment-patterns-in-italy-an-observational-study-interim-analysis
#22
JOURNAL ARTICLE
Fabrizio Stocchi, Paolo Barone, Roberto Ceravolo, Maria Francesca De Pandis, Leonardo Lopiano, Nicola Modugno, Alessandro Padovani, Manuela Pilleri, Alessandro Tessitore, Mario Zappia
BACKGROUND: Oral levodopa remains the mainstay of treatment for Parkinson's disease (PD). However, as PD progresses, response to treatment may fluctuate. Managing fluctuations can be demanding for clinicians and patients. There is a paucity of real-world studies reporting on PD management in patients with fluctuations in treatment response, especially in patients with advanced stages of PD. The multicentre, observational Parkinson's Disease Fluctuations treatment PAthway (PD-FPA) study describes the real-life management of response fluctuations in Italian patients with advanced PD...
December 2024: Annals of Medicine
https://read.qxmd.com/read/38378400/propolis-use-in-dentistry-a-narrative-review-of-its-preventive-and-therapeutic-applications
#23
REVIEW
Hayat Alghutaimel, Manal Matoug-Elwerfelli, Mayada Alhaji, Fatimah Albawardi, Venkateshbabu Nagendrababu, Paul Michael Howell Dummer
Propolis is a resinous substance produced naturally by bees, and it consists of the exudates of plants mixed with enzymes, wax, and pollen. Propolis continues to gain considerable scientific interest due to its potential health benefits. The modern-day use of propolis in pharmaceutical preparations, such as toothpastes, mouthwashes, chewable tablets, mucoadhesive gels, and sprays, is increasing. However, the effectiveness of using propolis-containing pharmaceuticals in dentistry is not clear. The present paper aims to review the literature on the dental applications of propolis in preventive dentistry, periodontics, oral medicine, and restorative dentistry and discuss its clinical effectiveness...
February 19, 2024: International Dental Journal
https://read.qxmd.com/read/38375522/molecular-identification-and-antifungal-susceptibility-profiles-of-etiologic-agents-of-oral-candidiasis-among-hiv-positive-patients-a-multicenter-study
#24
JOURNAL ARTICLE
Hamid Morovati, Malihe Jokari, Saba Eslami, Kamiar Zomorodian, Katayoun Taeri, Nesa Khalaf, Hossein Khodadadi
BACKGROUND AND PURPOSE: Human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) is a serious risk factor for oral candidiasis (OC). In this regard, the present study aimed to investigate the frequency of Candida species collected from the oropharyngeal cavity of HIV-positive patients and the sensitivity of these isolates to antifungal drugs. MATERIALS AND METHODS: Oral samples were collected from 169 HIV-positive patients. In addition to culture-based methods, a molecular assay via the polymerase chain reaction-restriction fragment length polymorphism method was applied to identify isolates using the MspI restriction enzyme...
June 2023: Current Medical Mycology
https://read.qxmd.com/read/38374827/the-protective-effect-of-roflumilast-against-acute-hepatotoxicity-caused-by-methotrexate-in-wistar-rats-in-vivo-evaluation
#25
JOURNAL ARTICLE
Riyadh S Almalki
INTRODUCTION: Methotrexate (MTX) is one of the most widely used drugs in cancer chemotherapy and treating rheumatoid arthritis. The hepatotoxicity of MTX is one of its major side effects. Roflumilast (ROF) has been recognized to have antioxidant and anti-inflammatory activity in in-vivo and in-vitro models. The present study aimed to explore the potential protective effects of roflumilast against MTX-induced liver toxicity in male Wistar rats. METHODS: High dose of 5 mg/kg for 4 consecutive days subcutaneous (S...
2024: Drug Design, Development and Therapy
https://read.qxmd.com/read/38364735/beneficial-effect-of-honokiol-and-magnolol-on-polyol-pathway-and-oxidative-stress-parameters-in-the-testes-of-diabetic-rats
#26
JOURNAL ARTICLE
Katarzyna Szałabska-Rąpała, Maria Zych, Weronika Borymska, Piotr Londzin, Sławomir Dudek, Ilona Kaczmarczyk-Żebrowska
In diabetes hyperglycemia, excessive production of free radicals and present oxidative stress lead to many complications in the body, including male reproductive system disorders. To prevent the development of diabetic complications in the testes resulting from them, it seems beneficial to include compounds considered as natural antioxidants. Honokiol and magnolol are neolignans obtained from magnolia bark, which possess proven antioxidant properties. The aim of this study was to evaluate the effect of honokiol and magnolol on the parameters of oxidative stress, polyol pathway and glycation products in the testes as well as on selected biochemical parameters in the blood serum of rats with type 2 diabetes...
February 14, 2024: Biomedicine & Pharmacotherapy
https://read.qxmd.com/read/38363061/phase-1-healthy-volunteer-study-of-al01211-an-oral-non-brain-penetrant-glucosylceramide-synthase-inhibitor-to-treat-fabry-disease-and-type-1-gaucher-disease
#27
JOURNAL ARTICLE
Michael Babcock, Jianhong Zheng, Jessica Gail Shurr, Li Li, Bing Wang, Pedro Huertas, Philip John Ryan, Yuqiao Shen, Marvin Garovoy
Glycosphingolipid (GSL) storage diseases are caused by deficiencies in the enzymes that metabolize different GSLs in the lysosome. Glucosylceramide synthase (GCS) inhibitors reduce GSL production and have potential to treat multiple GSL storage diseases. AL01211 is a potent, oral GCS inhibitor being developed for the treatment of Type 1 Gaucher disease and Fabry disease. AL01211 has minimal central nervous system penetration, allowing for treatment of peripheral organs without risking CNS-associated adverse effects...
February 16, 2024: Clinical Pharmacology in Drug Development
https://read.qxmd.com/read/38357701/design-synthesis-molecular-docking-and-in-vitro-studies-of-2-mercaptoquinazolin-4-3-h-ones-as-potential-anti-breast-cancer-agents
#28
JOURNAL ARTICLE
Manal A Alossaimi, Yassine Riadi, Ghaida N Alnuwaybit, Shadab Md, Huda Mohammed Alkreathy, Engy Elekhnawy, Mohammed H Geesi, Safar M Alqahtani, Obaid Afzal
Triple-negative breast cancer (TNBC) comprises 10 % to 20 % of breast cancer, however, it is more dangerous than other types of breast cancer, because it lacks druggable targets, such as the estrogen receptors (ER) and the progesterone receptor (PR), and has under expressed receptor tyrosine kinase, ErbB2. Present targeted therapies are not very effective and other choices include invasive procedures like surgery or less invasive ones like radiotherapy and chemotherapy. This study investigated the potential anticancer activity of some novel quinazolinone derivatives that were designed on the structural framework of two approved anticancer drugs, Ispinesib (KSP inhibitor) and Idelalisib (PI3Kδ inhibitor), to find out solutions for TNBC...
March 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38357682/protective-and-ameliorative-effects-of-hydroethanolic-extract-of-piper-nigrum-l-stem-against-antiretroviral-therapy-induced-hepatotoxicity-and-dyslipidemia-in-wistar-rats
#29
JOURNAL ARTICLE
Doreen Enyang, Mubo A Sonibare, Armelle D Tchamgoue, Lauve R Y Tchokouaha, Fanta S Yadang, Gael N Nfor, Christelle W Kom, Patrick D H Betote, Cedric F Tchinda, Steveng S K Tiogo, Gabriel A Agbor
Antiretroviral therapy (ART) has revolutionized the lives of people living with HIV/AIDS by overall improving their quality of life and increasing life expectancy. However, ART-associated hepatotoxicity and metabolic disorders in HIV/AIDS patients are growing concerns to clinicians, especially due to the long-term use of the drugs. This study reported on the phytochemical and pharmacological profile of hydroethanolic extracts of Piper nigrum stem (PNS) and evaluated its protective effect against tenofovir/lamivudine/efavirenz (TLE)-induced hepatotoxicity and dyslipidemia in Wistar rats...
2024: Journal of Toxicology
https://read.qxmd.com/read/38351730/the-neuroprotective-effects-of-curcumin-nanoparticles-on-the-cerebral-ischemia-reperfusion-injury-in-the-rats-the-roles-of-the-protein-kinase-rna-like-er-kinase-extracellular-signal-regulated-kinase-and-transcription-factor-eb-proteins
#30
JOURNAL ARTICLE
Yalda Saghari, Monireh Movahedi, Majid Tebianian, Maliheh Entezari
OBJECTIVE: Reduction of cerebral ischemia-reperfusion injury (IRI)/re-oxygenation injury, is defined as the paradoxical exacerbation of the cellular dysfunction and death, following restoration of the blood flow to previously ischemic tissues. The re-establishment of blood flow is essential to salvage the ischemic tissues. As a result, the treatment of IRI with novel therapies, which have fewer side effects, are of great importance. Therefore, this study aimed to investigate the effects of curcumin nanoparticle (CN) pre-treatment on the cerebral I/R rat model...
January 31, 2024: Cell Journal
https://read.qxmd.com/read/38349492/n-butanol-fraction-of-moringa-seed-attenuates-arsenic-intoxication-by-regulating-the-uterine-inflammatory-and-apoptotic-pathways
#31
JOURNAL ARTICLE
Suryashis Jana, Angshita Ghosh, Arindam Dey, Hasina Perveen, Pikash Pratim Maity, Shilpa Maji, Sandip Chattopadhyay
The adverse effects of arsenic-chelating drugs make it essential to replace invasive chelating therapy with non-invasive oral therapy for arsenic poisoning. The goal of the current investigation was to determine whether the uterine damage caused by arsenization could be repaired by the n-butanol fraction of Moringa oleifera seed (NB). The rats were orally administered with arsenic (10 mg/kg BW) for the initial 8 days, followed by NB (50 mg/kg) for the next 8 days without arsenic. The probable existence of different components in NB was evaluated by HPLC-MS...
February 13, 2024: Environmental Science and Pollution Research International
https://read.qxmd.com/read/38347740/phenytoin-enzyme-induction-for-management-of-supratherapeutic-tacrolimus-levels-due-to-drug-drug-interaction-with-nirmatrelvir-ritonavir-case-series-and-discussion
#32
JOURNAL ARTICLE
Jennifer Marsh, Angela T Logan, Erin P Bilgili, Lyndsey J Bowman, Allyssa R Webb
DISCLAIMER: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. PURPOSE: Nirmatrelvir/ritonavir is one of few options for outpatient treatment of COVID-19, but its use has been limited in transplant recipients due to significant drug interactions with immunosuppressants...
February 13, 2024: American Journal of Health-system Pharmacy: AJHP
https://read.qxmd.com/read/38344704/-in-vitro-gluten-degradation-using-recombinant-eurygaster-integriceps-prolyl-endoprotease-implications-for-celiac-disease
#33
JOURNAL ARTICLE
Effat Noori, Mojgan Bandehpour, Mohammad Reza Zali, Bahram Kazemi
BACKGROUND: Celiac disease (CD) is a gluten-sensitive chronic autoimmune enteropathy. A strict life-long gluten-free diet is the only efficient and accepted treatment until now. However, maintaining a truly gluten-free status is both difficult and costly, often resulting in a social burden for the person. Moreover, 2 to 5 percent of patients fail to improve clinically and histologically upon elimination of dietary gluten. Therefore, novel therapeutic approaches, including gluten degrading enzymes, are an unmet need of celiac patients...
July 2023: Iranian Journal of Biotechnology
https://read.qxmd.com/read/38342928/ipomoea-carnea-mitigates-ethanol-induced-ulcers-in-irradiated-rats-via-nrf2-ho-1-pathway-an-in-vivo-and-in-silico-study
#34
JOURNAL ARTICLE
Mosad A Ghareeb, Hala Sh Mohammed, Tarek Aboushousha, Dina M Lotfy, Maha A M El-Shazly, Mansour Sobeh, Eman F S Taha
The aim of this study was to investigate the potential of Ipomoea carnea flower methanolic extract (ICME) as a natural gastroprotective therapy against ethanol-induced gastric ulcers, particularly in individuals exposed to ionizing radiation (IR). The study focused on the Nrf2/HO-1 signaling pathway, which plays a crucial role in protecting the gastrointestinal mucosa from oxidative stress and inflammation. Male Wistar rats were divided into nine groups, the control group received distilled water orally for one week, while other groups were treated with ethanol to induce stomach ulcers, IR exposure, omeprazole, and different doses of ICME in combination with ethanol and/or IR...
February 12, 2024: Scientific Reports
https://read.qxmd.com/read/38342181/to-evaluate-the-effect-of-endothelin-receptor-agonist-irl-1620-alone-and-in-combination-with-donepezil-in-modulating-neurodegeneration-elicited-by-amyloid-%C3%AE-in-rats
#35
JOURNAL ARTICLE
Eshani Mahajan, Anupam Raja, Amit Raj Sharma, Ashish Jain, Praisy K Prabha, Ajay Prakash, Bikash Medhi
The development of efficient therapies for Alzheimer''s disease is essential since it is a serious public health problem. This investigation sought to ascertain any potential synergistic benefits of treating Alzheimer's disease with IRL-1620 monotherapy in addition to Donepezil. Additionally, the effect of IRL-1620 was evaluated using different doses (5 μg/kg,7 μg/kg, and 9 μg/kg). The study further assessed neurobehavioral, biochemical, molecular, and histopathological parameters to evaluate the efficacy of both IRL1620 by its own and in association with Donepezil...
February 9, 2024: Experimental Neurology
https://read.qxmd.com/read/38327209/design-synthesis-and-biological-investigation-of-quinazoline-derivatives-as-multitargeting-therapeutics-in-alzheimer-s-disease-therapy
#36
JOURNAL ARTICLE
Akash Verma, Digambar Kumar Waiker, Neha Singh, Anima Roy, Namrata Singh, Poorvi Saraf, Bhagwati Bhardwaj, Sairam Krishnamurthy, Surendra Kumar Trigun, Sushant Kumar Shrivastava
An efficient and promising method of treating complex neurodegenerative diseases like Alzheimer's disease (AD) is the multitarget-directed approach. Here in this work, a series of quinazoline derivatives ( AV-1 to AV-21 ) were rationally designed, synthesized, and biologically evaluated as multitargeted directed ligands against human cholinesterase (hChE) and human β-secretase (hBACE-1) that exhibit moderate to good inhibitory effects. Compounds AV-1 , AV-2 , and AV-3 from the series demonstrated balanced and significant inhibition against these targets...
February 8, 2024: ACS Chemical Neuroscience
https://read.qxmd.com/read/38327067/influence-of-genetic-polymorphisms-in-vascular-endothelial-related-genes-on-the-clinical-outcome-of-axitinib-in-patients-with-metastatic-renal-cell-carcinoma
#37
JOURNAL ARTICLE
Kazuyuki Numakura, Ryoma Igarashi, Makoto Takahashi, Taketoshi Nara, Sohei Kanda, Mitsuru Saito, Shintaro Narita, Takamitsu Inoue, Takenori Niioka, Masatomo Miura, Tomonori Habuchi
OBJECTIVE: Axitinib is an oral multi-target tyrosine kinase inhibitor used for the treatment of renal cell carcinoma (RCC). Because of the severe adverse events (AEs) associated with axitinib, patients often need dose reductions or discontinue its use, highlighting the need for effective biomarkers to assess efficacy and/or AEs. The aim of this study was to investigate the relationship between single nucleotide polymorphisms (SNPs) in genes involved in the pharmacodynamic action of axitinib and clinical prognosis and AEs in metastatic RCC (mRCC) patients...
December 31, 2024: Cancer Biology & Therapy
https://read.qxmd.com/read/38323615/efficacy-and-safety-of-bempedoic-acid-in-patients-with-high-cardiovascular-risk-an-update
#38
JOURNAL ARTICLE
Ozge Telci Caklili, Manfredi Rizzo, Mustafa Cesur
Statins play a significant role in the prevention of cardiovascular (CV) diseases (CVDs); however, non-adherence with statin treatment or statin intolerance (mainly attributed to muscleassociated side effects) is not uncommon. New agents such as bempedoic acid (BA) can provide more treatment options. BA is administered orally, once daily, at a dose of 180 mg in current clinical practice. It can decrease circulating low-density lipoprotein cholesterol (LDL-C) levels by nearly 30% as monotherapy or by 20% as an add-on to statins...
February 7, 2024: Current Vascular Pharmacology
https://read.qxmd.com/read/38322061/anti-inflammatory-role-of-trypsin-rutoside-and-bromelain-combination-in-temporomandibular-joint-osteoarthritis-a-systematic-review
#39
REVIEW
Amlendu Shekhar, Nisha Maddheshiya, Adit, Varun Rastogi, Karthikeyan Ramalingam
The objective of this systematic review was to assess the effectiveness, acceptability, and safety of systemic enzyme therapy, consisting of trypsin, bromelain, and rutoside trihydrate, as an anti-inflammatory agent, either when utilized independently or in conjunction with non-steroidal anti-inflammatory drugs (NSAIDs). This systematic review adhered to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Two studies met the inclusion criteria and were assessed in the review...
January 2024: Curēus
https://read.qxmd.com/read/38313882/lagerstroemia-speciosa-pers-lythraceae-ethanolic-extract-attenuates-isoniazid-induced-oxidative-stress-and-hepatic-inflammation-in-rats
#40
JOURNAL ARTICLE
T Rohit Singh, Devaraj Ezhilarasan, Munusamy Karthick, Karthik Shree Harini
Background Drug-induced liver injury is a common cause of acute liver failure. Isoniazid (INH) is used as a first-line treatment for tuberculosis. Clinical and experimental studies have reported abnormal liver function after INH therapy. Lagerstroemia speciosa Pers., commonly known as banaba, has been traditionally used to treat various ailments including diabetes and obesity due to its antioxidant and anti-inflammatory properties. Aim To investigate the hepatoprotective effect of ethanolic banaba leaf extract (EBLE) against INH-induced hepatotoxicity in rats...
January 2024: Curēus
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