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https://www.readbyqxmd.com/read/28528304/the-relationships-between-arsenic-methylation-and-both-skin-lesions-and-hypertension-caused-by-chronic-exposure-to-arsenic-in-drinking-water
#1
Binggan Wei, Jiangping Yu, Jing Wang, Linsheng Yang, Hairong Li, Chang Kong, Yajuan Xia, Kegong Wu
The associations between arsenic exposure, arsenic methylation, and the prevalence of skin lesions and hypertension are investigated. The results indicate that the HS (hypertension and skin lesions) group and the S (skin lesions) group have higher urinary concentrations of iAs (inorganic arsenic), MMA (monomethylarsonic acid), DMA (dimethylarsinous acid) and%MMA, and lower SMI (secondary arsenic methylation index) compared to the H (hypertension) and N (without both hypertension and skin lesions) groups. The arsenic content in water which caused H may be lower than that which caused HS and S...
May 12, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28528200/sputum-transcriptomics-reveal-up-regulation-of-il-1-receptor-family-members-in-severe-asthma
#2
Christos Rossios, Stelios Pavlidis, Uruj Hoda, Chih-Hsi Kuo, Coen Wiegman, Kirsty Russell, Kai Sun, Matthew J Loza, Frederic Baribaud, Andrew L Durham, Oluwaseun Ojo, Rene Lutter, Anthony Rowe, Aruna Bansal, Charles Auffray, Ana Sousa, Julie Corfield, Ratko Djukanovic, Yike Guo, Peter J Sterk, Kian Fan Chung, Ian M Adcock
BACKGROUND: Sputum analysis in asthma is used to define airway inflammatory processes and may guide therapy. OBJECTIVE: To determine differential gene and protein expression in sputum samples from patients with severe asthma (SA) compared to mild-moderate non-smoking asthmatics (MMA). METHODS: Induced sputum was obtained from non-smoking SA (SAn), smokers/ex-smokers with SA (SAsm), MMA and healthy non-smoking controls. Differential cell counts, microarray analysis of cell pellets and SOMAscan analysis of sputum analytes was performed...
May 17, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28505484/arsenic-speciation-in-the-phloem-exudates-of-rice-and-its-role-in-arsenic-accumulation-in-rice-grains
#3
Wenling Ye, Jingjing Zhang, Ting Fan, Hongjuan Lu, Haiyan Chen, Xuede Li, Rimao Hua
Arsenic (As) speciation in the phloem sap of rice plants and its role in As accumulation in rice grains remain largely uncharacterized. In the present study, we tested As chemical species in the phloem exudates of rice treated with arsenate [As(V)], arsenite [As(III)], monomethylarsonic acid [MMA(V)], or dimethylarsinic acid [DMA(V)]. As(V) was the main species (58%) in the phloem exudates of As(V)-exposed rice, whereas As(III) predominated (69%) in As(III)-exposed rice. A large proportion of As(V) (41-45%) was observed in the phloem exudates when rice was treated with methylated As species...
May 12, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28498668/kinetics-of-the-reactions-of-no3-radical-with-methacrylate-esters
#4
Li Zhou, A R Ravishankara, Steven S Brown, Mahmoud Idir, Kyle J Zarzana, Veronique Daele, Abdelwahid Mellouki
Two different experimental methods (relative rate and absolute rate methods) were used to measure the rate coefficients for the reactions of NO3 radical with six methacrylate esters: methyl methacrylate (MMA, k1), ethyl methacrylate (EMA, k2), propyl methacrylate (PMA, k3), isopropyl methacrylate (IPMA, k4), butyl methacrylate (BMA, k5), isobutyl methacrylate (IBMA, k6). In the relative rate method, the loss of the esters relative to that of a reference compound was followed in a 7300 L Teflon-walled chamber at (298±2) K and (1000±5) hpa...
May 12, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28497574/protein-destabilization-and-loss-of-protein-protein-interaction-are-fundamental-mechanisms-in-cbla-type-methylmalonic-aciduria
#5
Tanja Plessl, Céline Bürer, Seraina Lutz, Wyatt W Yue, Matthias R Baumgartner, D Sean Froese
Mutations in the human MMAA gene cause the metabolic disorder cblA-type methylmalonic aciduria (MMA), although knowledge of the mechanism of dysfunction remains lacking. MMAA regulates the incorporation of the cofactor adenosylcobalamin, generated from the MMAB adenosyltransferase, into the destination enzyme methylmalonyl-CoA mutase (MUT). This function of MMAA depends on its GTPase activity, which is stimulated by an interaction with MUT. Here, we present 67 new patients with cblA-type MMA, identifying 19 novel mutations...
May 12, 2017: Human Mutation
https://www.readbyqxmd.com/read/28480917/femtosecond-to-microsecond-observation-of-the-photochemical-reaction-of-1-2-di-quinolin-2-yl-disulfide-with-methyl-methacrylate
#6
Daisuke Koyama, Paul M Donaldson, Andrew J Orr-Ewing
The mechanism of the thiol-ene reaction induced by 330 nm ultraviolet excitation of 1,2-di(quinolin-2-yl)disulfide (QSSQ) in the presence of methyl methacrylate (MMA) is investigated by sub-picosecond to microsecond transient absorption spectroscopy. The measurements, spanning more than seven orders of magnitude of time, directly reveal multiple radical reaction steps. The ground state quinoliene-2-thiyl radical (QS) is formed with a time constant of ∼200 fs by photolysis of QSSQ, followed by (64 ± 1)% decay of the initially formed QS radical because of solvent cage induced geminate recombination and QS dimer formation with a rate coefficient of (3...
May 8, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28479390/arsenic-metabolism-and-one-carbon-metabolism-at-low-moderate-arsenic-exposure-evidence-from-the-strong-heart-study
#7
Miranda Jones Spratlen, Mary V Gamble, Maria Grau-Perez, Chin-Chi Kuo, Lyle G Best, Joseph Yracheta, Kevin Francesconi, Walter Goessler, Yasmin Mossavar-Rahmani, Meghan Hall, Jason G Umans, Amanda Fretts, Ana Navas-Acien
B-vitamins involved in one-carbon metabolism (OCM) can affect arsenic metabolism efficiency in highly arsenic exposed, undernourished populations. We evaluated whether dietary intake of OCM nutrients (including vitamins B2, B6, folate (B9), and B12) was associated with arsenic metabolism in a more nourished population exposed to lower arsenic than previously studied. Dietary intake of OCM nutrients and urine arsenic was evaluated in 405 participants from the Strong Heart Study. Arsenic exposure was measured as the sum of iAs, monomethylarsonate (MMA) and dimethylarsenate (DMA) in urine...
May 4, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28477405/multilaboratory-validation-of-first-action-method-2016-04-for-determination-of-four-arsenic-species-in-fruit-juice-by-high-performance-liquid-chromatography-inductively-coupled-plasma-mass-spectrometry
#8
Kevin Kubachka, Douglas T Heitkemper, Sean Conklin
Before being designated AOAC First Action Official Method(SM) 2016.04, the U.S. Food and Drug Administration’s method, EAM 4.10 High Performance Liquid Chromatography–Inductively Coupled Plasma–Mass Spectrometric Determination of Four Arsenic Species in Fruit Juice, underwent both a single-laboratory validation and a multilaboratory validation (MLV) study. Three federal and five state regulatory laboratories participated in the MLV study, which is the primary focus of this manuscript. The method was validated for inorganic arsenic (iAs) measured as the sum of the two iAs species arsenite [As(III)] and arsenate [As(V)], dimethylarsinic acid (DMA), and monomethylarsonic acid (MMA) by analyses of 13 juice samples, including three apple juice, three apple juice concentrate, four grape juice, and three pear juice samples...
May 5, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28477300/comparison-of-access-hole-filling-materials-for-screw-retained-implant-prostheses-12-month-in-vivo-study
#9
Rémy Tanimura, Shiro Suzuki
BACKGROUND: Screw retained implant prostheses seem to be an efficient restorative method to prevent peri-implantitis caused by cement excess around the abutment. The drawback of the screw-retained prostheses is the difficulty to realize an efficient access-hole filling functionally and aesthetically. Up to now, few in vitro and in vivo studies were reported in the literature. The aim of this study was to evaluate clinical performances of two direct filling materials through a period of 12 months...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28472079/levels-of-infants-urinary-arsenic-metabolites-related-to-formula-feeding-and-weaning-with-rice-products-exceeding-the-eu-inorganic-arsenic-standard
#10
Antonio J Signes-Pastor, Jayne V Woodside, Paul McMullan, Karen Mullan, Manus Carey, Margaret R Karagas, Andrew A Meharg
Early childhood inorganic arsenic (i-As) exposure is of particular concern since it may adversely impact on lifetime health outcomes. Infants' urinary arsenic (As) metabolites were analysed in 79 infants by inductively coupled plasma-mass spectrometric detection (IC-ICP-MS) to evaluate i-As exposure pre- and post-weaning. Levels of i-As in rice-based weaning and infants' foods were also determined to relate to urinary As levels. Higher As levels, especially of monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA), were found in urine from formula fed infants compared to those breastfed...
2017: PloS One
https://www.readbyqxmd.com/read/28457128/matrix-extension-and-multilaboratory-validation-of-arsenic-speciation-method-eam-%C3%A2-4-10-to-include-wine
#11
Courtney K Tanabe, Helene Hopfer, Susan E Ebeler, Jenny Nelson, Sean D Conklin, Kevin M Kubachka, Robert A Wilson
A multilaboratory validation (MLV) was performed to extend the U.S. Food and Drug Administration's (FDA) analytical method Elemental Analysis Manual (EAM) §4.10, High Performance Liquid Chromatography-Inductively Coupled Plasma-Mass Spectrometric Determination of Four Arsenic Species in Fruit Juice, to include wine. Several method modifications were examined to optimize the method for the analysis of dimethylarsinic acid, monomethylarsonic acid, arsenate (AsV), and arsenite (AsIII) in various wine matrices with a range of ethanol concentrations by liquid chromatography-inductively coupled plasma-mass spectrometry...
May 11, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28447237/effects-of-metformin-versus-placebo-on-vitamin-b12-metabolism-in-non-diabetic-breast-cancer-patients-in-cctg-ma-32
#12
Ana Elisa Lohmann, Mira F Liebman, William Brien, Wendy R Parulekar, Karen A Gelmon, Lois E Shepherd, Jennifer A Ligibel, Dawn L Hershman, Priya Rastogi, Ingrid A Mayer, Timothy J Hobday, Julie Lemieux, Alastair Mark Thompson, Kathleen I Pritchard, Timothy Joseph Whelan, Som D Mukherjee, Haji I Chalchal, Vanessa Bernstein, Vuk Stambolic, Bingshu E Chen, Pamela Jean Goodwin
BACKGROUND: Metformin is associated with low levels of vitamin B12 (VitB12) in patients with diabetes. The CCTG/MA.32 trial investigates the effects of metformin vs placebo on breast cancer (BC) outcomes in non-diabetic high-risk BC patients. We analyzed VitB12 at baseline and after 6 months of metformin (versus placebo) in the first 492 patients with paired blood samples. METHODS: VitB12 was analyzed centrally in baseline and 6-month fasting plasma. Levels <181 pmol/L were considered deficient, 181-221 pmol/L borderline, and ≥222 pmol/L sufficient...
April 26, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28447119/maxillary-sinus-lift-with-beta-tricalcium-phosphate-%C3%AE-tcp-in-edentulous-patients-a-nanotomographic-and-raman-study
#13
Florence Pascaretti-Grizon, Bernard Guillaume, Lisa Terranova, Baptiste Arbez, Hélène Libouban, Daniel Chappard
Sinus lift elevation restores bone mass at the maxilla in edentulate patients before the placement of dental implants. It consists of opening the lateral side of the sinus and grafting beta-tricalcium phosphate granules (β-TCP) under the olfactory membrane. Bone biopsies were obtained in five patients after 60 weeks. They were embedded undecalcified in poly(methyl methacrylate) (pMMA); blocks were analyzed by nanocomputed tomography (nanoCT); specific areas were studied by Raman microspectroscopy. Remnants of β-TCP were osseointegrated and covered with mineralized bone; osteoid tissue was also filling the inner porosity...
April 26, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28443783/risk-due-to-exposure-to-metallic-elements-in-a-birdshot-factory
#14
Piero Lovreglio, Giovanni De Filippis, Brizio Tamborrino, Ignazio Drago, Rossana Rotondi, Annamaria Gallone, Matteo Paganelli, Pietro Apostoli, Leonardo Soleo
The contribution of biological and environmental monitoring to the risk assessment of occupational exposure to lead (Pb), arsenic (As) and antimony (Sb) was studied in 18 workers at a birdshot factory (Exposed) and in 18 control workers (Controls), by the determination both of airborne Pb (PbA) and As (AsA) only in the exposed workers, and blood Pb (PbB), erythrocytic zinc protoporphyrin (ZPP), urinary Sb (SbU) and the urinary As species in exposed workers and controls. PbA (12-42 μg/m(3)) and AsA (1-4 μg/m(3)) were strongly correlated (r = 0...
April 26, 2017: Archives of Environmental & Occupational Health
https://www.readbyqxmd.com/read/28441492/caenorhabditis-elegans-prmt-7-and-prmt-9-are-evolutionarily-conserved-protein-arginine-methyltransferases-with-distinct-substrate-specificities
#15
Andrea Hadjikyriacou, Steven Gerard Clarke
Caenorhabditis elegans protein arginine methyltransferases PRMT-7 and PRMT-9 are two evolutionarily conserved enzymes, with distinct orthologs in plants, invertebrates, and vertebrates. Biochemical characterization of these two enzymes reveals that they share much in common with their mammalian orthologs. C. elegans PRMT-7 produces only monomethyl arginine (MMA) and preferentially methylates R-X-R motifs in a broad collection of substrates, including human histone peptides and RG-rich peptides. In addition, the activity of the PRMT-7 enzyme is dependent on temperature, the presence of metal ions, and the reducing agent dithiothreitol (DTT)...
April 25, 2017: Biochemistry
https://www.readbyqxmd.com/read/28441332/pregnant-sheep-in-a-farm-environment-did-not-develop-anaemia
#16
Gabrielle C Musk, Amanda James, Matthew W Kemp, Sara Ritchie, Andrew Ritchie, Michael Laurence
The aim of this study was to document the haematological profile of pregnant ewes throughout gestation. Sheep were divided into three groups (n = 8 per group): non-pregnant, singleton, or twin pregnancy. Blood samples were collected every 14 days from day 55 of gestation for haemoglobin concentration; packed cell volume; total protein; and albumin concentration. On days 55 and 125 of gestation blood was collected for trace element estimation: soluble copper and zinc; glutathione peroxidase (GSHPx); and methylmalonic acid (MMA)...
April 25, 2017: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/28441012/rgb-switchable-porous-electrospun-nanofiber-chemoprobe-filter-prepared-from-multifunctional-copolymers-for-versatile-sensing-of-ph-and-heavy-metals
#17
Fang-Cheng Liang, Chi-Ching Kuo, Bo-Yu Chen, Chia-Jung Cho, Chih-Chien Hung, Wen-Chang Chen, Redouane Borsali
Novel red-green-blue (RGB) switchable probes based on fluorescent porous electrospun (ES) nanofibers exhibiting high sensitivity to pH and mercury ions (Hg(2+)) were prepared with one type of copolymer (poly(methyl methacrylatete-co-1,8-naphthalimide derivatives-co-rhodamine derivative); poly(MMA-co-BNPTU-co-RhBAM)) by using a single-capillary spinneret. The MMA, BNPTU, and RhBAM moieties were designed to (i) permit formation of porous fibers, (ii) fluoresce for Hg(2+) detection, and (iii) fluoresce for pH, respectively...
May 3, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28436815/moyamoya-in-a-patient-with-fires-a-first-case-report
#18
Taylor Kaufman, Andrew White
Febrile infection-related epilepsy syndrome (FIRES) is a form of epileptic encephalopathy with severe refractory epilepsy that presents in previously healthy, school-aged children after significant febrile illness with concomitant rise in body temperature. Suspected causes include genetic or acquired channelopathies, as well as mitochondrial disturbances. In FIRES, the EEG shows diffuse slowing, generalized, and/or multifocal discharges. Seizures are present and resistant to treatment. Moyamoya angiopathy (MMA) is characterized by progressive stenosis of cerebral arteries and subsequent development of a network of collateral circulation that is prone to rupture...
2017: Neurodiagnostic Journal
https://www.readbyqxmd.com/read/28433864/arsenic-metabolism-and-cancer-risk-a-meta-analysis
#19
REVIEW
Brenda Gamboa-Loira, Mariano E Cebrián, Francisco Franco-Marina, Lizbeth López-Carrillo
OBJECTIVE: To describe the studies that have reported association measures between risk of cancer and the percentage distribution of urinary inorganic arsenic (iAs) metabolites by anatomical site, in non-ecological epidemiological studies. METHODS: Studies were identified in the PubMed database in the period from 1990 to 2015. Inclusion criteria were: non-ecological epidemiological study, with histologically confirmed cancer cases, reporting the percentage distribution of inorganic arsenic (iAs), monomethylated (MMA) and dimethylated (DMA) metabolites, as well as association measures with confidence intervals (CI) between cancer and %iAs and/or %MMA and/or %DMA...
April 20, 2017: Environmental Research
https://www.readbyqxmd.com/read/28425282/mechanical-force-sensitive-acrylic-latex-coating
#20
Meng Li, Weifeng Liu, Qi Zhang, Shiping Zhu
We prepared force sensitive acrylic latex coatings by covalently incorporating spiropyran mechanophore. The acrylic latexes were obtained through emulsion copolymerization of butyl acrylate (BA), methyl methacrylate (MMA) with vinyltriethoxysilane (VTES) as interparticle cross-linker, and (1'-(2-(methacryloyloxy)ethyl)-3',3'-dimethylspiro[chromene-2,2'-indolin]-6-yl)methyl methacrylate) (SP) as intraparticle cross-linker. The latexes of P(BA-co-MMA-co-SP-co-VTES) were subsequently cast onto Teflon-coated surface to form latex coatings...
April 21, 2017: ACS Applied Materials & Interfaces
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