Read by QxMD icon Read


Tyler J D'Ovidio, Rebecca M Roberts, Dixa Gautam, Zefram D Marks, Manju Saraswathy, Jeffrey W Stansbury, Devatha P Nair
The enhanced in situ photopolymerization kinetics of methyl methacrylate (MMA) to poly(methyl methacrylate) (PMMA) through the incorporation of both inert and reactive nanogel (NG) fillers under ambient conditions has been demonstrated. In addition to the polymerization kinetics, the physical and chemical properties of the prepolymeric NG were also utilized to tune the thermoplasticity and mechanical properties of the PMMA polymer network. The protocol followed in this study imparts superior MMA photopolymerization kinetics (≥ 60% double-bond conversion within 15 min for > 35 wt% nanogel loadings and ≥ 95% double-bond conversion in < 60 min for all NG concentrations) when compared with traditional polymerization mechanisms...
June 2, 2018: Journal of the Mechanical Behavior of Biomedical Materials
Prasanna Kumarathilaka, Saman Seneweera, Andrew Meharg, Jochen Bundschuh
Arsenic (As) elevation in paddy soils will have a negative impact on both the yield and grain quality of rice (Oryza sativa L.). The mechanistic understanding of As uptake, translocation, and grain filling is an important aspect to produce rice grains with low As concentrations through agronomical, physico-chemical, and breeding approaches. A range of factors (i.e. physico-chemical, biological, and environmental) govern the speciation and mobility of As in paddy soil-water systems. Major As uptake transporters in rice roots, such as phosphate and aquaglyceroporins, assimilate both inorganic (As(III) and As(V)) and organic As (DMA(V) and MMA(V)) species from the rice rhizosphere...
June 13, 2018: Science of the Total Environment
M Däzlä, M Yilmaz, F Karaloglu, R Karamert, V C Goksu, S A Kahraman, Y K Kemaloglu
Objective: : We aimed to present our clinical experience with maxillomandibular advancement (MMA) for the treatment of obstructive sleep apnea (OSA) syndrome and to compare our results with literature data. Materials and Methods: : The patients who were operated for OSA in the last 10 years were included in the study. A detailed patient's charts review was retrospectively performed. Inclusion criteria were to be available with preoperative and postoperative polysomnography data...
June 2018: Nigerian Journal of Clinical Practice
Elisa Passaglia, Francesca Cicogna, Federica Costantino, Serena Coiai, Stefano Legnaioli, Giulia Lorenzetti, Silvia Borsacchi, Marco Geppi, Francesca Telesio, Stefan Heun, Andrea Ienco, Manuel Serrano-Ruiz, Maurizio Peruzzini
Black phosphorus (bP) has been recently investigated for next generation nanoelectronic multifunctional devices. However, the intrinsic instability of exfoliated bP (the bP nanoflakes) toward both moisture and air has so far overshadowed its practical implementation. In order to contribute to fill this gap, we report here the preparation of new hybrid polymer-based materials where bP nanoflakes (bPn) exhibit a significantly improved stability. The new materials have been prepared by different synthetic paths including: (i) the mixing of conventionally liquid-phase exfoliated bP (in dimethyl sulfoxide, DMSO) with poly(methyl methacrylate) (PMMA) solution; (ii) the direct exfoliation of bP in a polymeric solution; (iii) the in situ radical polymerization after exfoliating bP in the liquid monomer (methyl methacrylate, MMA)...
March 27, 2018: Chemistry of Materials: a Publication of the American Chemical Society
Unnikrishnan M Chandrasekharan, Zeneng Wang, Yuping Wu, W H Wilson Tang, Stanley L Hazen, Sihe Wang, M Elaine Husni
BACKGROUND: Rheumatoid arthritis (RA) patients are at high risk of developing cardiovascular disease (CVD). In RA, chronic inflammation may lead to endothelial dysfunction, an early indicator of CVD, owing to diminished nitric oxide (NO) production. Because L-arginine is the sole precursor of NO, we hypothesized that levels of L-arginine metabolic products reflecting NO metabolism are altered in patients with RA. METHODS: Plasma samples from patients with RA (n = 119) and age- and sex-matched control subjects (n = 238) were used for this study...
June 8, 2018: Arthritis Research & Therapy
Taotao Hui, Zhi Bo Chang, Feng Han, Yongjun Rui
RATIONALE: Monomelic amyotrophy (MMA) is a benign motor neuron disease with bilateral muscular atrophy in asymmetry and abnormal in the electromyography (EMG). However, we report a case by the muscle biopsy which shows symptoms of slowly progressive amyotrophy despite having a normal EMG. PATIENT CONCERNS: A 51-year-old male was diagnosed with a lower limb amyotrophy, insidious at the onset and located in the distal thigh and the proximal crus near the knee, slowly progressive weakness, and wasting of his right gastrocnemius muscle for the last 20 years...
June 2018: Medicine (Baltimore)
Yantus A B Neolaka, Ganden Supriyanto, Handoko Darmokoesoemo, Heri Septya Kusuma
The adsorption performance of Cr(VI) on the Cr(VI)-imprinted poly(4-VP-co-MMA) (IIP) supported on Activated Indonesia (Ende-Flores) natural zeolite (ANZ) structure for Cr(VI) removal from aqueous solution have been studied. Cr(VI)-imprinted-poly(4-VP-co-MMA)-ANZ (IIP-ANZ) was synthesized using Cr(VI) as a template, 4-vinylphiridine (4-VP) as a complex agent, methyl methacrylate (MMA) as a monomer agent, ethylene glycol dimethylacrylate (EGDMA) as cross-linker and benzoyl peroxide (BPO) as an initiator. XRD, FTIR, SEM-EDX and BET was performed to characterize the synthesized materials...
April 2018: Data in Brief
Saskia Lm van Loon, Anna M Wilbik, Uzay Kaymak, Edwin R van den Heuvel, Volkher Scharnhorst, Arjen-Kars Boer
Background Methylmalonic acid (MMA) can detect functional vitamin B12 deficiencies as it accumulates early when intracellular deficits arise. However, impaired clearance of MMA from blood due to decreased glomerular filtration rate (eGFR) also results in elevated plasma MMA concentrations. Alternative to clinical trials, a data mining approach was chosen to quantify and compensate for the effect of decreased eGFR on MMA concentration. Methods Comprehensive data on patient's vitamin B12 , eGFR and MMA concentrations were collected ( n = 2906)...
January 1, 2018: Annals of Clinical Biochemistry
Poojitha Balakrishnan, Miranda R Jones, Dhananjay Vaidya, Maria Tellez-Plaza, Wendy S Post, Joel D Kaufman, Suzette J Bielinski, Kent Taylor, Kevin Francesconi, Walter Goessler, Ana Navas-Acien
We investigated the effect of candidate variants in AS3MT (arsenic (III) methyltransferase) with urinary arsenic metabolites and their principal components in a subset of 264 participants in the Multi-Ethnic Study of Atherosclerosis (MESA). Urinary arsenic species, including inorganic arsenic (iAs), monomethylarsonate (MMA), dimethylarsinate (DMA), and arsenobetaine (Ab), were measured using high performance liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICPMS) and corrected for organic sources from seafood consumption by regressing Ab on arsenic species using a validated method...
June 5, 2018: International Journal of Environmental Research and Public Health
Jamie L Young, Lu Cai, J Christopher States
Exposure to environmental stressors during susceptible windows of development can result in negative health outcomes later in life, a concept known as the Developmental Origins of Health and Disease (DOHaD). There is a growing body of evidence that exposures to metals early in life (in utero and postnatal) increase the risk of developing adult diseases such as cancer, cardiovascular disease, non-alcoholic fatty liver disease, and diabetes. Of particular concern is exposure to the metalloid arsenic, a drinking water contaminant and worldwide health concern...
June 6, 2018: Systems Biology in Reproductive Medicine
C R John, S Gandhi, A R Sakharia, T T James
The primary objective of this review was to establish the effectiveness of maxillomandibular advancement (MMA) as a successful treatment modality in improving airway patency in patients with obstructive sleep apnoea (OSA). A systematic and detailed search was performed using PubMed Central, covering the period January 2000 to December 2015, with well-defined selection criteria. The authors independently conducted the study selection, data extraction, and assessed the risk of bias of the included studies. Twenty studies met the inclusion criteria...
June 2, 2018: International Journal of Oral and Maxillofacial Surgery
Jonas Bianchi, Guilherme Machado Porciúncula, Leonardo Koerich, Jaqueline Ignácio, Larry Miller Wolford, João Roberto Gonçalves
This retrospective cohort study aimed to assess, three-dimensionally, mandible and maxilla changes following maxillomandibular advancement (MMA), with and without repositioning of TMJ articular discs. The sample comprised cone-beam computed tomography data from 32 subjects: group 1 (n = 12) without disc displacement and group 2 (n = 20) with bilateral disc repositioning. An automatic cranial base superimposition method was used to register the images at three time points: T1 (preoperative), T2 (postoperative), and T3 (at least 11 months follow-up)...
May 18, 2018: Journal of Cranio-maxillo-facial Surgery
Yuefeng He, Ruobing Zhang, Song Xiaoxiao, Shang Li, Wu Xinan, Dahai Huang
Accumulating evidences have shown that apoptosis plays an important role in mediating the therapeutic effects and toxicity of arsenic. Fas and Bax genes are critical regulatory genes for apoptosis. In this study, we investigated the association between levels of Fas and Bax expression and the three arsenic species (inorganic arsenic (iAs), monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA)) in vivo and vitro. Three arsenic species in urine were measured and levels of Fas and Bax expression were examined by the quantitative real-time PCR (qPCR) for all subjects...
June 1, 2018: Gene
Xiaoyan Zhou, Yazhou Cui, Jinxiang Han
Methylmalonic acidemia (MMA) is a lethal, severe heterogeneous disorder of methylmalonate and cobalamin (cbl; vitamin B12) metabolism with poor prognosis. Two main forms of the disease have been identified, isolated methylmalonic acidurias and combined methylmalonic aciduria and homocystinuria, which is respectively caused by different gene mutations. Here, we review the improvement of pathogenesis, diagnosis and treatment in MMA. Importantly, the reported epidemiological data of MMA patients in China and the hot mutation sites in Chinese patients are listed, which will aid in improving healthcare of Chinese patients in the future...
May 2018: Intractable & Rare Diseases Research
Hana Shiraz, Simon J Peake, Tim Davey, Neil R Cameron, Rico F Tabor
HYPOTHESIS: Film-forming polymer latex particles of diameter <300 nm can be prepared in the complete absence of surfactants, stabilised in part by silica nanoparticles through a Pickering type emulsion polymerisation. Control of the silica wettability through modulation of reaction pH or by reaction of the nanoparticles with a hydrophobic silane results in silica-covered latex particles. EXPERIMENTS: The oil-in-water polymerisation process used methyl methacrylate (MMA) and n-butyl acrylate (BA) as co-monomers, potassium persulphate (KPS) as an initiator and a commercially available colloidal nano-silica (Ludox®-TM40)...
May 15, 2018: Journal of Colloid and Interface Science
Alina Levtova, Paula J Waters, Daniela Buhas, Sébastien Lévesque, Christiane Auray-Blais, Joe T R Clarke, Rachel Laframboise, Bruno Maranda, Grant A Mitchell, Catherine Brunel-Guitton, Nancy E Braverman
BACKGROUND: The clinical significance of combined malonic and methylmalonic aciduria due to ACSF3 deficiency (CMAMMA) is controversial. In most publications, affected patients were identified during the investigation of various complaints. METHODS: Using a cross-sectional multicenter retrospective natural history study, we describe the course of all known CMAMMA individuals in the province of Quebec. RESULTS: We identified 25 CMAMMA patients (6 months to 30 years old) with a favorable outcome regardless of treatment...
June 1, 2018: Journal of Inherited Metabolic Disease
Chunlu Gao, Shuang Hu, Meihua Guo, Xin Hai, Jin Zhou
PURPOSE: This study evaluated pharmacokinetics (PK) and safety profiles of single agent arsenic trioxide (ATO, As2 O3 ) administrated as continuous slow-rate infusion in patients with newly diagnosed acute promyelocytic leukemia. PATIENTS AND METHODS: Patients received 0.16 mg/kg ATO per day. ATO was given for 40 min infusion on the first day followed by 18-20 h daily at a very slow rate with infusion speed of 8 drips/min. During the first week, plasma samples were collected immediately before next administration on each day, and 0...
May 29, 2018: Cancer Chemotherapy and Pharmacology
Min He, Haoran Hu, Ping Wang, Haitian Fu, Jiugang Yuan, Qiang Wang, Xuerong Fan
Silk sericin (SS) derived from silkworms has the characteristics of anti-oxidation, antibacterial, and biocompatibility, however, high solubility in water restricted its applications in biomedical fields. In the present work, SS was enzymatically graft-copolymerized with a hydrophobic vinyl monomer of methyl methacrylate (MMA), through a free radical reaction, through the combination use of hydrogen peroxide and horseradish peroxidase (HRP). Efficacy of the HRP-mediated reaction was examined by means of FTIR, SDS-PAGE, and SEC chromatogram...
May 26, 2018: International Journal of Biological Macromolecules
Hind A Beydoun, May A Beydoun, Hong Cheng, Anjum Khan, Shaker M Eid, Carolina Alvarez-Garriga, Colin Anderson-Smits, Alan B Zonderman, Danica Marinac-Dabic
The purpose of this cross-sectional study is to examine the relationship between surgical treatments for sleep-disordered breathing (SDB) and composite measure of surgical complications in a nationally representative sample of hospital discharges among U.S. adults. We performed secondary analyses of 33,679 hospital discharges from the 2002-2012 Nationwide Inpatient Sample that corresponded to U.S. adults (≥18 years) who were free of head-and-neck neoplasms, were diagnosed with SDB and had undergone at least one of seven procedures...
May 24, 2018: Journal of Cranio-maxillo-facial Surgery
P van Hagen, R de Jonge, M I van Berge Henegouwen, G J Hötte, E P van der Stok, J Lindemans, J J B van Lanschot, B P L Wijnhoven
The aim of this study is to determine the prevalence and incidence of vitamin B12 deficiency after esophagectomy for cancer. It is unknown if patients after esophagectomy with gastric tube reconstruction are at an increased risk for vitamin B12 deficiency. A cross-sectional cohort (group A) and a prospective cohort (group B) of patients who underwent esophagectomy for cancer in two tertiary referral centers in the Netherlands were included. Serum levels of holo-transcobalamin (Holo-TC) and methyl malonic acid (MMA) were determined...
December 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"