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Roxane Guillod-Magnin, Beat J Brüschweiler, Rafael Aubert, Max Haldimann
Inorganic arsenic (iAs) is a contaminant present in food, especially in rice and rice-based products. Toxicity of arsenic compounds (As) depends on species and oxidative state. Inorganic arsenic species, such as arsenite (As(III)) and arsenate (As(V)), are more bioactive and toxic than organic arsenic species, like methylarsonic acid (MMA(V)) and dimethylarsinic acid (DMA(V)) or arsenosugars and arsenobetaine. An ion chromatography-inductively coupled plasma-mass spectroscopy (IC-ICP-MS) method was developed to separate the four following arsenic anions: As(III), As(V), MMA(V) and DMA(V)...
February 16, 2018: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Vicent Yusà, Rosa Pérez, Alfredo Sánchez, Olga Pardo, Marta Roca
We present a new approach to arsenic (As) risk assessment using biomonitoring. In this pilot study we determined the levels of total and speciated urinary arsenicin 109 Spanish school children aged between 6 and 11 years, and interpreted these concentrations in a risk assessment context. The geometric mean (GM) for total As (TAs) was 33.82 μ/L. The order of occurrence and average concentrations of the different species was arsenobetaine (AsB) (100%, 15 μg/L), dimethylarsinic (DMA) (97%, 8.32 μg/L), monomethylarsonic (MMA) (26%, 0...
February 11, 2018: Science of the Total Environment
Cyrill Matenaers, Bastian Popper, Alexandra Rieger, Rüdiger Wanke, Andreas Blutke
The accuracy of quantitative stereological analysis tools such as the (physical) disector method substantially depends on the precise determination of the thickness of the analyzed histological sections. One conventional method for measurement of histological section thickness is to re-embed the section of interest vertically to its original section plane. The section thickness is then measured in a subsequently prepared histological section of this orthogonally re-embedded sample. However, the orthogonal re-embedding (ORE) technique is quite work- and time-intensive and may produce inaccurate section thickness measurement values due to unintentional slightly oblique (non-orthogonal) positioning of the re-embedded sample-section...
2018: PloS One
Shaohua Ma, Xiaohui Zhan, Minggang Yang, Fang Lan, Yao Wu, Zhongwei Gu
Circulating tumor cells (CTCs) played a significant role in early diagnosis and prognosis of carcinomas, and efficient capture of CTCs was highly desired to provide important and reliable evidence for clinical diagnosis. In present work, we successfully synthesized functional magnetic Fe3O4/P(MMA-AA) composite nanoparticles (FCNPs) inspired by a counterbalance concept for recognition and capture of CTCs. This counterbalance, composed of polyethylene glycol (PEG) suppressing cell adhesion and anti-epithelial-cell-adhesion-molecule (anti-EpCAM) antibody targeting tumor cells, could both enhance the specific capture of tumor cells and reduce unspecific adhesion of normal cells...
April 1, 2018: Journal of Nanoscience and Nanotechnology
Sofie Wilkens Knappe, Liselotte Sonnesen
The purpose of this article is to review 1) mandibular advancement device (MAD) - indication, treatment success, and side effects; 2) maxillomandibular advancement (MMA) surgery of the jaws - indication, treatment success, and side effects; and 3) current perspectives. Both MAD and MMA are administered to increase the upper airway volume and reduce the collapsibility of the upper airway. MAD is noninvasive and is indicated as a first-stage treatment in adult patients with mild-to-moderate obstructive sleep apnea (OSA) and in patients with severe OSA unable to adhere to continuous positive airway pressure (CPAP)...
2018: Nature and Science of Sleep
Apolline Imbard, Nuria Garcia Segarra, Marine Tardieu, Pierre Broué, Juliette Bouchereau, Samia Pichard, Hélène Ogier de Baulny, Abdelhamid Slama, Charlotte Mussini, Guy Touati, Marie Danjoux, Pauline Gaignard, Hannes Vogel, François Labarthe, Manuel Schiff, Jean-François Benoist
BACKGROUND AND OBJECTIVES: Patients affected with methylmalonic acidemia (MMA) and propionic acidemia (PA) exhibit diverse long-term complications and poor outcome. Liver disease is not a reported complication. The aim of this study was to characterize and extensively evaluate long-term liver involvement in MMA and PA patients. PATIENTS AND METHODS: We first describe four patients who had severe liver involvement during the course of their disease. Histology showed fibrosis and/or cirrhosis in 3 patients...
February 7, 2018: Molecular Genetics and Metabolism
Meiwei Qi, Ke Li, Yongli Zheng, Tahir Rasheed, Yongfeng Zhou
A Novel thermoresponsive hyperbranched multiarm copolymer with a hydrophobic hyperbranched poly[3-ethyl-3-(hydroxymethyl)oxetane] (HBPO) core and many poly(acrylamide-co-acrylonitrile) (P(AAm-co-AN)) arms was for the first time synthesized through a reversible addition-fragmentation chain-transfer (RAFT) polymerization. These copolymers show reversible, sharp and controlled temperature-responsive phase transitions at the upper critical solution temperature (UCST) in water and electrolyte solution. It is the first report on the hyperbranched copolymers with a UCST transition...
February 11, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
Ignacio López-García, Juan José Marín-Hernández, Manuel Hernández-Córdoba
Freshly in situ prepared ferrite particles were used for the micro-solid phase extraction of arsenic species. When the separation was carried out at pH 8, inorganic arsenic (As(III) + As(V)) and monomethylarsonic acid (MMA) were retained in the magnetic material. A second aliquot was treated with 2,3 dimercapto propanol, leading to the retention of As(V)+MMA, while a third aliquot was first treated with sodium thiosulphate, in which case only inorganic arsenic passed to the solid phase. In all cases, the solid residue collected by a magnet was suspended in a dilute nitric acid solution containing Triton X-100 and introduced into the electrothermal atomizer to obtain the analytical signal of arsenic...
May 1, 2018: Talanta
Fabrizio Minichilli, Fabrizio Bianchi, Anna Maria Ronchi, Francesca Gorini, Elisa Bustaffa
Arsenic is ubiquitous and has a potentially adverse impact on human health. We compared the distribution of concentrations of urinary inorganic arsenic plus methylated forms (uc(iAs+MMA+DMA)) in four Italian areas with other international studies, and we assessed the relationship between uc(iAs+MMA+DMA) and various exposure factors. We conducted a human biomonitoring study on 271 subjects (132 men) aged 20-44, randomly sampled and stratified by area, gender, and age. Data on environmental and occupational exposure and dietary habits were collected through a questionnaire...
February 9, 2018: International Journal of Environmental Research and Public Health
Megan M Niedzwiecki, Xinhua Liu, Huiping Zhu, Megan N Hall, Vesna Slavkovich, Vesna Ilievski, Diane Levy, Abu B Siddique, Muhammad G Kibriya, Faruque Parvez, Tariqul Islam, Alauddin Ahmed, Ana Navas-Acien, Joseph H Graziano, Richard H Finnell, Habibul Ahsan, Mary V Gamble
BACKGROUND: Inorganic arsenic (As) is methylated via one carbon metabolism (OCM) to mono- and dimethylated arsenicals (MMA and DMA), facilitating urinary excretion. Hyperhomocysteinemia (HHcys), a marker of impaired OCM, is a risk factor for As-induced skin lesions, but the influences of single nucleotide polymorphisms (SNPs) in OCM genes on Hcys, As metabolism and skin lesion risk is unclear. OBJECTIVES: To (i) explore genetic sources of Hcys and the causal role of HHcys in As-induced skin lesion development using OCM genetic proxies for HHcys and (ii) identify OCM SNPs associated with urinary As metabolite proportions and/or skin lesion incidence...
February 2, 2018: Environment International
Anne Cm Pelzer, Frank Mma van der Heijden, Erik den Boer
Objective: To investigate the evidence-based treatment of catatonia in adults. The secondary aim is to develop a treatment protocol. Materials and methods: A systematic review of published treatment articles (case series, cohort or randomized controlled studies) which examined the effects of particular interventions for catatonia and/or catatonic symptoms in adult populations and used valid outcome measures was performed. The articles for this review were selected by searching the electronic databases of the Cochrane Library, MEDLINE, EMBASE and PSYCHINFO...
2018: Neuropsychiatric Disease and Treatment
Helena Skröder, Karin Engström, Doris Kuehnelt, Maria Kippler, Kevin Francesconi, Barbro Nermell, Fahmida Tofail, Karin Broberg, Marie Vahter
BACKGROUND: It has been proposed that interactions between selenium and arsenic in the body may affect their kinetics and toxicity. However, it is unknown how the elements influence each other in humans. OBJECTIVES: We aimed to investigate potential interactions in the methylation of selenium and arsenic. METHODS: Urinary selenium (U-Se) and arsenic (U-As) were measured using inductively coupled plasma mass spectrometry (ICPMS) in samples collected from pregnant women (n=226) in rural Bangladesh at gestational weeks (GW) 8, 14, 19, and 30...
February 1, 2018: Environmental Health Perspectives
Ririko Tsuboi, Jun-Ichi Sasaki, Haruaki Kitagawa, Itsumi Yoshimoto, Fumio Takeshige, Satoshi Imazato
OBJECTIVE: Aiming to achieve bioactive dental resins that promote healing of surrounding tissues, we developed novel poly(2-hydroxyethyl methacrylate/trimethylolpropane trimethacrylate) (polyHEMA/TMPT) particles. These particles have been reported to be useful as a non-biodegradable carrier for fibroblast growth factor-2 (FGF-2) in vitro. The aim of this study was to evaluate the ability of an adhesive resin incorporating FGF-2-loaded polymer particles to promote tissue regeneration in vitro and in vivo...
January 29, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
Christina A Spivey, Junling Wang, Yanru Qiao, Ya-Chen Tina Shih, Jim Y Wan, Julie Kuhle, Samuel Dagogo-Jack, William C Cushman, Marie Chisholm-Burns
BACKGROUND: Previous research found racial and ethnic disparities in meeting medication therapy management (MTM) eligibility criteria implemented by the Centers for Medicare & Medicaid Services (CMS) in accordance with the Medicare Modernization Act (MMA). OBJECTIVE: To examine whether alternative MTM eligibility criteria based on the CMS Part D star ratings quality evaluation system can reduce racial and ethnic disparities. METHODS: This study analyzed the Beneficiary Summary File and claims files for Medicare beneficiaries linked to the Area Health Resource File...
February 2018: Journal of Managed Care & Specialty Pharmacy
Lipeng Feng, Shiyun Chen, Yangbo Hu
During infection, Mycobacterium tuberculosis (Mtb) colonizes macrophages or necrotic granulomas, in which low pH is one of the major challenges. The PhoPR two-component regulatory system and the cytosolic redox sensor WhiB3 both play important roles in the response to low pH by Mtb However, whether close association exists between PhoPR and WhiB3 remains unclear. In this study, the positive regulation of whiB3 by PhoPR in mycobacteria was characterized. We observed that the expression patterns of the whiB3 gene under acidic conditions are different among mycobacterial species, suggesting that the regulation of whiB3 differs among mycobacteria...
January 29, 2018: Journal of Bacteriology
Tamar Caceres, Abishek Thakur, Owen M Price, Nicole Ippolito, Jun Li, Jun Qu, Orlando Acevedo, Joan Michelle Hevel
Protein arginine methyltransferase 7 (PRMT7) is unique within the PRMT family as it is the only isoform known to exclusively make monomethylarginine (MMA). Given its role in epigenetics, the mechanistic basis for the strict monomethylation activity is under investigation. It is thought that PRMT7 enzymes are unable to add a second methyl group because of steric hindrances in the active site which restrict them to monomethylation. To test this, we probed the active site of Trypanosomal PRMT7 (TbPRMT7) using accelerated molecular dynamics, site-directed mutagenesis, kinetic, binding, and product analyses...
January 29, 2018: Biochemistry
Tomoyo Okazaki, Hiroyasu Koizumi, Hiroshi Nogawa, Akihisa Kodaira, Tomotaro Nihei, Hideo Matsumura
This study aimed to investigate how different compositions of experimental silane-based primers in a methyl methacrylate solution containing 3-(trimethoxysilyl)propyl methacrylate (3-TMSPMA) or 3-(4-methacryloyloxyphenyl)propyl trimethoxysilane (3-MPPTS) might act as silicon dioxide bonding agents. With or without post-silanization heat treatment, primer-treated quartz discs were bonded using the MMA-TBB resin and their bond strengths were evaluated. The disks were primed with one of the following materials: 1 mol% 3-TMSPMA, 2 mol% 3-TMSPMA, 1 mol% 3-MPPTS, and 2 mol% 3-MPPTS...
January 26, 2018: Dental Materials Journal
Maria Grau-Perez, Chin-Chi Kuo, Matthew O Gribble, Poojitha Balakrishnan, Miranda Jones Spratlen, Dhananjay Vaidya, Kevin A Francesconi, Walter Goessler, Eliseo Guallar, Ellen K Silbergeld, Jason G Umans, Lyle G Best, Elisa T Lee, Barbara V Howard, Shelley A Cole, Ana Navas-Acien
BACKGROUND: High arsenic exposure has been related to diabetes, but at low-moderate levels the evidence is mixed. Arsenic metabolism, which is partly genetically controlled and may rely on certain B vitamins, plays a role in arsenic toxicity. OBJECTIVE: We evaluated the prospective association of arsenic exposure and metabolism with type 2 diabetes and insulin resistance. METHODS: We included 1,838 American Indian men and women free of diabetes (median age, 36 y)...
December 20, 2017: Environmental Health Perspectives
Dan Chang, Zhiying Li, Xiao Wang, Chongyi Zhu, Alideertu Dong, Ge Gao
A novel N-halamine terpolymer, i.e., P(ADMH-MMA-HEMA)-Cl, with high antibacterial efficacies were fabricated via a free-radical copolymerization of 3-allyl-5,5-dimethylhydantoin(ADMH), methyl methacrylate(MMA), and hydroxyethyl methacrylate (HEMA), followed by a chlorination treatment using sodium hypochlorite as chlorinating agent. A controllable synthesis of P(ADMH-MMA-HEMA)-Cl was achieved by tuning chlorination conditions, such as chlorination temperature, reactant concentration, chlorination time, etc...
January 11, 2018: Colloids and Surfaces. B, Biointerfaces
Roger E Thomas, Bennett C Thomas
OBJECTIVES: To assess injury rates in all mixed martial arts (MMA) studies. METHODS: Six online databases were searched until November 2017 including MEDLINE, EMBASE, CINAHL, Web of Science, PubMed, Google/Google Scholar and conference proceedings. All included studies were entered in Pub Med Single Citation Matcher and all citation chains followed. Abstracts and titles were assessed for relevance, data independently abstracted and risk of bias for all competition studies evaluated independently by two reviewers...
January 19, 2018: Physician and Sportsmedicine
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