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https://www.readbyqxmd.com/read/28647334/test-characteristics-of-milk-amyloid-a-elisa-somatic-cell-count-and-bacteriological-culture-for-detection-of-intramammary-pathogens-that-cause-subclinical-mastitis
#1
S Jaeger, F Virchow, P R Torgerson, M Bischoff, B Biner, S Hartnack, S R Rüegg
Bovine mastitis is an important disease in the dairy industry, causing economic losses as a result of withheld milk and treatment costs. Several studies have suggested milk amyloid A (MAA) as a promising biomarker in the diagnosis of mastitis. In the absence of a gold standard for diagnosis of subclinical mastitis, we estimated the diagnostic test accuracy of a commercial MAA-ELISA, somatic cell count (SCC), and bacteriological culture using Bayesian latent class modeling. We divided intramammary infections into 2 classes: those caused by major pathogens (e...
June 21, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28644821/zirconium-oxocluster-polymer-hybrid-nanoparticles-prepared-by-photoactivated-miniemulsion-copolymerization
#2
Cesare Benedetti, Paraskevi Flouda, Alice Antonello, Christine Rosenauer, Francisco F Perez-Pla, Katharina Landfester, Silvia Gross, Rafael Munoz-Espi
Photoactivated free radical miniemulsion copolymerization of methyl methacrylate (MMA) and the zirconium oxocluster Zr4O2(methacrylate)12 is used as an effective and fast preparation method of polymer/inorganic hybrid nanoparticles. The oxoclusters, covalently anchored to the polymer network, act as metal-organic cross-linkers, thus improving the thermomechanical properties of the resulting hybrid nanoparticles. Benzoin carbonyl organic compounds were used as photoinitiators. The obtained materials are compared in terms of cross-linking, effectiveness of cluster incorporation, and size distribution with the analogous nanoparticles produced by using conventional thermally-induced free radical miniemulsion copolymerization...
June 23, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28640505/associations-between-arsenic-3-oxidation-state-methyltransferase-as3mt-and-n-6-adenine-specific-dna-methyltransferase-1-n6amt1-polymorphisms-arsenic-metabolism-and-cancer-risk-in-a-chilean-population
#3
Rosemarie de la Rosa, Craig Steinmaus, Nicholas K Akers, Lucia Conde, Catterina Ferreccio, David Kalman, Kevin R Zhang, Christine F Skibola, Allan H Smith, Luoping Zhang, Martyn T Smith
Inter-individual differences in arsenic metabolism have been linked to arsenic-related disease risks. Arsenic (+3) methyltransferase (AS3MT) is the primary enzyme involved in arsenic metabolism, and we previously demonstrated in vitro that N-6 adenine-specific DNA methyltransferase 1 (N6AMT1) also methylates the toxic inorganic arsenic (iAs) metabolite, monomethylarsonous acid (MMA), to the less toxic dimethylarsonic acid (DMA). Here, we evaluated whether AS3MT and N6AMT1 gene polymorphisms alter arsenic methylation and impact iAs-related cancer risks...
June 22, 2017: Environmental and Molecular Mutagenesis
https://www.readbyqxmd.com/read/28637995/intracranial-bony-canal-of-the-middle-meningeal-artery-morphological-and-histological-analysis
#4
Michio Fujimoto, Naruhito Otsuka, Hiromitsu Ezure, Hiroshi Moriyama, Yuriko Inoue, Ryoichi Mori
The middle meningeal artery (MMA) can play an important role in the surgical revascularization. However, the MMA can be easily injured if it passes through a bony canal. We investigated the morphological and histological features of the bony canal to improve surgical results. MATERIALS AND METHODS: Fifty adult dry skulls were investigated. The length of the bony canal and the distance from the orbital rim to the bony canal were measured. Additionally, 28 cadaveric heads were examined histologically...
2017: Okajimas Folia Anatomica Japonica
https://www.readbyqxmd.com/read/28635953/rare-rnf213-variants-in-the-c-terminal-region-encompassing-the-ring-finger-domain-are-associated-with-moyamoya-angiopathy-in-caucasians
#5
Stéphanie Guey, Markus Kraemer, Dominique Hervé, Thomas Ludwig, Manoëlle Kossorotoff, Françoise Bergametti, Jan Claudius Schwitalla, Simone Choi, Lucile Broseus, Isabelle Callebaut, Emmanuelle Genin, Elisabeth Tournier-Lasserve
Moyamoya angiopathy (MMA) is a cerebral angiopathy affecting the terminal part of internal carotid arteries. Its prevalence is 10 times higher in Japan and Korea than in Europe. In East Asian countries, moyamoya is strongly associated to the R4810K variant in the RNF213 gene that encodes for a protein containing a RING-finger and two AAA+ domains. This variant has never been detected in Caucasian MMA patients, but several rare RNF213 variants have been reported in Caucasian cases. Using a collapsing test based on exome data from 68 European MMA probands and 573 ethnically matched controls, we showed a significant association between rare missense RNF213 variants and MMA in European patients (odds ratio (OR)=2...
June 21, 2017: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/28629683/the-relationship-between-dietary-intake-growth-and-body-composition-in-inborn-errors-of-intermediary-protein-metabolism
#6
Maureen Evans, Helen Truby, Avihu Boneh
OBJECTIVES: To examine relationships between dietary intake, growth and body composition patterns in patients with inborn errors of intermediary protein metabolism and to determine a safe protein:energy ratio (P:E ratio) associated with optimal growth outcomes. STUDY DESIGN: Retrospective longitudinal data of growth and dietary intake in patients (n = 75) with isovaleric acidemia (IVA; n = 7), methylmalonic acidemia/propionic acidemia (MMA/PA; n = 14), urea cycle defects (UCD; n = 44), classical maple syrup urine disease (MSUD; n = 10) were collected...
June 16, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/28628747/laser-ablation-of-silver-in-liquid-organic-monomer-influence-of-experimental-parameters-on-the-synthesized-silver-nanoparticles-graphite-colloids
#7
Maxime Delmée, Gregory Mertz, Julien Bardon, Adeline Marguier, Lydie Ploux, Vincent Roucoules, David Ruch
During the last decade, synthesizing silver nanoparticles (Ag NPs) by Liquid Phase-Pulsed Laser Ablation (LP-PLA) has attracted a lot of attention. Basically, this technique allows producing various metallic nanoparticles with controlled size, shape, composition or surroundings in several liquids (i.e.: water, ethanol, acetone, toluene,…). Recently, such processes have been studied in liquid organic monomer such as methyl methacrylate (MMA). However, the influence of the laser parameters on the materials synthesised in such reactive liquid and their features were not fully investigated so far...
June 19, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28626207/influence-of-polymerization-properties-of-4-meta-mma-based-resin-on-the-activity-of-fibroblast-growth-factor-2
#8
Haruaki Kitagawa, Kahoru Takeda, Ririko Tsuboi, Mikako Hayashi, Jun-Ichi Sasaki, Satoshi Imazato
Dental adhesive resins based on 4-methacryloxyethyl trimellitate anhydride (4-META)/methyl methacrylate (MMA) have been utilized for root-end filling and the bonding of fractured roots. To increase the success rate of these treatments, it would be beneficial to promote the healing of surrounding tissue by applying growth factors. In this study, the influences of the polymerization properties of 4-META/MMA-based resins on the activity of fibroblast growth factor-2 (FGF-2) were evaluated in vitro. The temperature increase caused by the heat generation during polymerization of the 4-META/MMA-based resin was insufficient to change the structure and function of FGF-2...
June 15, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/28626205/designing-an-antibacterial-acrylic-resin-using-the-cosolvent-method-effect-of-ethanol-on-the-optical-and-mechanical-properties-of-a-cold-cure-acrylic-resin
#9
Takashi Nezu, Futami Nagano-Takebe, Kazuhiko Endo
Antimicrobial cetylpyridinium chloride (CPC) has low miscibility with acrylic resin monomer but can be homogeneously mixed using ethanol as a cosolvent. This study investigated the effects of ethanol addition on the properties of a cold-cure acrylic resin. Ethanol was an excellent cosolvent for CPC and methyl methacrylate monomer (MMA), but the cured resin exhibited a strong change in coloration to yellow (ΔE*ab>8) and a drastically reduced bending strength (from 97 to 25 MPa) and elastic modulus (from 2...
June 15, 2017: Dental Materials Journal
https://www.readbyqxmd.com/read/28618975/a-black-cohosh-extract-causes-hematologic-and-biochemical-changes-consistent-with-a-functional-cobalamin-deficiency-in-female-b6c3f1-n-mice
#10
Michelle C Cora, William Gwinn, Ralph Wilson, Debra King, Suramya Waidyanatha, Grace E Kissling, Sukhdev S Brar, Dorian Olivera, Chad Blystone, Greg Travlos
Black cohosh rhizome, available as a dietary supplement, is most commonly marketed as a remedy for dysmenorrhea and menopausal symptoms. A previous subchronic toxicity study of black cohosh dried ethanolic extract (BCE) in female mice revealed a dose-dependent ineffective erythropoiesis with a macrocytosis consistent with the condition known as megaloblastic anemia. The purpose of this study was to investigate potential mechanisms by which BCE induces these particular hematological changes. B6C3F1/N female mice (32/group) were exposed by gavage to vehicle or 1,000 mg/kg BCE for 92 days...
January 1, 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28598268/effects-of-pulmonary-exposure-to-chemically-distinct-welding-fumes-on-neuroendocrine-markers-of-toxicity
#11
K Krajnak, K Sriram, C Johnson, J R Roberts, R Mercer, G R Miller, O Wirth, J M Antonini
Exposure to welding fumes may result in disorders of the pulmonary, cardiovascular, and reproductive systems. Welders are also at a greater risk of developing symptoms similar to those seen in individuals with idiopathic Parkinson's disease. In welders, there are studies that suggest that alterations in circulating prolactin concentrations may be indicative of injury to the dopamine (DA) neurons in the substantia nigra. The goal of these studies was to use an established model of welding particulate exposure to mimic the effects of welding fume inhalation on reproductive functions...
June 9, 2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28595795/relationship-between-arsenic-and-selenium-in-workers-occupationally-exposed-to-inorganic-arsenic
#12
Beata Janasik, Anna Zawisza, Beata Malachowska, Wojciech Fendler, Magdalena Stanislawska, Renata Kuras, Wojciech Wasowicz
The interaction between arsenic (As) and selenium (Se) has been one of the most extensively studied. The antagonism between As and Se suggests that low Se status plays an important role in aggravating arsenic toxicity in diseases development. The objective of this study was to assess the Se contents in biological samples of inorganic As exposed workers (n=61) and in non-exposed subjects (n=52). Median (Me) total arsenic concentration in urine of exposed workers was 21.83μg/g creat. (interquartile range (IQR) 15...
July 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/28586093/agreement-between-jaw-muscle-activity-measurement-with-portable-single-channel-electromyography-and-polysomnography-in-children
#13
Claudia Restrepo, Frank Lobbezoo, Eduardo Castrillon, Peter Svensson, Adriana Santamaria, Claudia Alvarez, Ruben Manrique, Daniele Manfredini
BACKGROUND: Polysomnography (PSG) is the gold standard for sleep bruxism (SB) assessment. High economical costs, complex technical equipment, and unfamiliar laboratory setting limit its use in children. AIM: To determine the night-to-night variability of electromyography (EMG) episodes during a five-night recording with the GrindCare Measure (GCM), and the agreement in the assessment of masticatory muscle activity (MMA) between GCM and PSG in children. DESIGN: Forty-seven children from clinics of Universidad CES participated...
June 6, 2017: International Journal of Paediatric Dentistry
https://www.readbyqxmd.com/read/28584416/effect-of-comonomer-of-methacrylic-acid-on-flexural-strength-and-adhesion-of-staphylococcus-aureus-to-heat-polymerized-poly-methyl-methacrylate-resin-an-in-vitro-study
#14
Lokendra Gupta, I N Aparna, Sujatha Bhat, Kishore Ginjupalli
AIMS AND OBJECTIVE: The purpose of the present study was to evaluate and compare flexural strength and Staphylococcus aureus adhesion of heat-activated poly (methyl methacrylate [MMA]) resin modified with a comonomer of methacrylic acid (MAA) and MMA monomer. MATERIALS AND METHODS: Comonomer preparation was done with the addition of varying concentration of MAA (0, 15, 20, and 25 wt %) to the MMA of conventional heat-activated denture base resin to prepare the specimens...
April 2017: Journal of Indian Prosthodontic Society
https://www.readbyqxmd.com/read/28568311/defining-the-clinical-relevance-of-red-blood-cell-autoantibodies-by-monocyte-monolayer-assay
#15
Marina C A V Conrado, Amanda N D'Avila, Juliana B Vieira, Silvia L Bonifacio, Francisco C A Gomes, Marcia R Dezan, Valeria B Oliveira, Ingrid H Ribeiro, Luciana T C M Tucunduva, Alfredo Mendrone-Júnior, Vanderson Rocha, Carla L Dinardo
BACKGROUND: The Monocyte Monolayer Assay (MMA) is an in vitro simulation of red blood cell (RBC) alloantibody behavior. It has been classically applied to predict the risks of post-transfusion hemolytic reactions when transfusing incompatible RBC units. Quantifying erythrophagocytosis by MMA may be an interesting option for situations where there is doubt whether a RBC autoantibody is mediating significant hemolysis. Here, we present three situations involving RBC autoantibodies in which the MMA was decisive for clarifying the diagnosis and choosing the best clinical treatment...
May 31, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/28564490/effect-of-comonomers-on-physical-properties-and-cell-attachment-to-silica-methacrylate-acrylate-hybrids-for-bone-substitution
#16
Justin J Chung, Brian S T Sum, Siwei Li, Molly M Stevens, Theoni K Georgiou, Julian R Jones
Hybrids with a silica network covalently bonded to a polymer are promising materials for bone repair. Previous work on synthesizing methyl methacrylate (MMA) based copolymers by reversible addition-fragmentation chain transfer (RAFT) polymerization gives high tailorability of mechanical properties since sophisticated polymer structures can be designed. However, more flexible hybrids would be beneficial. Here, n-butyl methacrylate (BMA) and methyl acrylate (MA) based hybrids are produced. Unlike MMA, BMA and MA hybrids do not show plastic deformation, and BMA hybrid has strain to failure of 33%...
May 31, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/28553665/urinary-arsenic-speciation-in-children-and-pregnant-women-from-spain
#17
Antonio J Signes-Pastor, Manus Carey, Jesus Vioque, Eva M Navarrete-Muñoz, Cristina Rodríguez-Dehli, Adonina Tardón, Miren Begoña-Zubero, Loreto Santa-Marina, Martine Vrijheid, Maribel Casas, Sabrina Llop, Sandra Gonzalez-Palacios, Andrew A Meharg
Inorganic arsenic (i-As) is a non-threshold human carcinogen that has been associated with several adverse health outcomes. Exposure to i-As is of particular concern among pregnant women, infants and children, as they are specifically vulnerable to the adverse health effects of i-As, and in utero and early-life exposure, even low to moderate levels of i-As, may have a marked effect throughout the lifespan. Ion chromatography-mass spectrometry detection (IC-ICP-MS) was used to analyse urinary arsenic speciation, as an exposure biomarker, in samples of 4-year-old children with relatively low-level arsenic exposure living in different regions in Spain including Asturias, Gipuzkoa, Sabadell and Valencia...
2017: Expo Health
https://www.readbyqxmd.com/read/28552184/exploring-racial-disparity-in-obesity-a-mediation-analysis-considering-geo-coded-environmental-factors
#18
Qingzhao Yu, Richard A Scribner, Claudia Leonardi, Lu Zhang, Chi Park, Liwei Chen, Neal R Simonsen
Research shows aconsistent racial disparity in obesity between white and black adults in the United States. Accounting for the disparity is a challenge given the variety of the contributing factors, the nature of the association, and the multilevel relationships among the factors. We used the multivariable mediation analysis (MMA) method to explore the racial disparity in obesity considering not only the individual behavior but also geospatially derived environmental risk factors. Results from generalized linear models (GLM) were compared with those from multiple additive regression trees (MART) which allow for hierarchical data structure, and fitting of nonlinear and complex interactive relationships...
June 2017: Spatial and Spatio-temporal Epidemiology
https://www.readbyqxmd.com/read/28549828/deficiency-of-long-isoforms-of-nfe2l1-sensitizes-min6-pancreatic-%C3%AE-cells-to-arsenite-induced-cytotoxicity
#19
Qi Cui, Jingqi Fu, Yuxin Hu, Yongfang Li, Bei Yang, Lu Li, Jing Sun, Chengjie Chen, Guifan Sun, Yuanyuan Xu, Qiang Zhang, Jingbo Pi
Increasing evidence indicates that chronic inorganic arsenic exposure is associated with type 2 diabetes (T2D), a disease of growing prevalence. Pancreatic β-cells were targeted and damaged by oxidative stress induced by arsenite. We previously showed that nuclear factor erythroid 2 like 2 (Nfe2l2)-deficient pancreatic β-cells were vulnerable to cell damage induced by oxidative stressors including arsenite, due to a muted antioxidant response. Like nuclear factor erythroid 2 like 2 (NFE2L2), NFE2L1 also belongs to the cap 'n' collar (CNC) basic-region leucine zipper (bZIP) transcription factor family, and regulates antioxidant response element (ARE) related genes...
May 24, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28549489/blood-pressure-associated-with-arsenic-methylation-and-arsenic-metabolism-caused-by-chronic-exposure-to-arsenic-in-tube-well-water
#20
Bing Gan Wei, Bi Xiong Ye, Jiang Ping Yu, Lin Sheng Yang, Hai Rong Li, Ya Juan Xia, Ke Gong Wu
OBJECTIVE: The effects of arsenic exposure from drinking water, arsenic metabolism, and arsenic methylation on blood pressure (BP) were observed in this study. METHODS: The BP and arsenic species of 560 participants were determined. Logistic regression analysis was applied to estimate the odds ratios of BP associated with arsenic metabolites and arsenic methylation capability. RESULTS: BP was positively associated with cumulative arsenic exposure (CAE)...
May 2017: Biomedical and Environmental Sciences: BES
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