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https://www.readbyqxmd.com/read/28095466/substrate-stiffness-controls-osteoblastic-and-chondrocytic-differentiation-of-mesenchymal-stem-cells-without-exogenous-stimuli
#1
Rene Olivares-Navarrete, Erin M Lee, Kathryn Smith, Sharon L Hyzy, Maryam Doroudi, Joseph K Williams, Ken Gall, Barbara D Boyan, Zvi Schwartz
Stem cell fate has been linked to the mechanical properties of their underlying substrate, affecting mechanoreceptors and ultimately leading to downstream biological response. Studies have used polymers to mimic the stiffness of extracellular matrix as well as of individual tissues and shown mesenchymal stem cells (MSCs) could be directed along specific lineages. In this study, we examined the role of stiffness in MSC differentiation to two closely related cell phenotypes: osteoblast and chondrocyte. We prepared four methyl acrylate/methyl methacrylate (MA/MMA) polymer surfaces with elastic moduli ranging from 0...
2017: PloS One
https://www.readbyqxmd.com/read/28076949/arsenic-methyltransferase-is-involved-in-arsenosugar-biosynthesis-by-providing-dma
#2
Xi-Mei Xue, Jun Ye, Georg Raber, Kevin A Francesconi, Gang Li, Hong Gao, Yu Yan, Christopher Rensing, Yong-Guan Zhu
Arsenic is an ubiquitous toxic element in the environment, and organisms have evolved different arsenic detoxification strategies. Studies on arsenic biotransformation mechanisms have mainly focused on arsenate reduction, arsenite oxidation, and arsenic methylation; little is known, however, about the pathway for the biosynthesis of arsenosugars, which are significant arsenic transformation products. Here, the involvement of arsenite S-Adenosylmethionine methyltransferase (ArsM) in arsenosugar synthesis is demonstrated for the first time...
January 11, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28070528/methylmalonic-acidemia-diagnosis-by-laboratory-methods
#3
Keyfi Fatemeh, Talebi Saeed, Varasteh Abdol-Reza
Methylmalonic acidemia (MMA) is usually caused by a deficiency of the enzyme methylmalonyl-CoA mutase (MCM), a defect in the transport or synthesis of its cofactor, adenosyl-cobalamin (cblA, cblB, cblC, cblF, cblD, and cblX), or deficiency of the enzyme methylmalonyl-CoA epimerase. A comprehensive diagnostic approach involves investigations of metabolites with tandem mass spectrometry, organic acid analysis with gas chromatography, enzymatic studies with fibroblast cell culture, and finally, mutation analysis...
October 2016: Reports of Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28069204/enhancement-of-thermal-and-mechanical-properties-of-poly-mma-co-ba-cloisite-30b-nanocomposites-by-ultrasound-assisted-in-situ-emulsion-polymerization
#4
Sachin Sharma, Maneesh Kumar Poddar, Vijayanand S Moholkar
This study reports synthesis and characterization of poly(MMA-co-BA)/Cloisite 30B (organo-modified montmorillonite clay) nanocomposites by ultrasound-assisted in-situ emulsion polymerization. Copolymers have been synthesized with MMA:BA monomer ratio of 4:1, and varying clay loading (1-5wt% monomer). The poly(MMA-co-BA)/Cloisite 30B nanocomposites have been characterized for their thermal and mechanical properties. Ultrasonically synthesized nanocomposites have been revealed to possess higher thermal degradation resistance and mechanical strength than the nanocomposites synthesized using conventional techniques...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28063275/a-survey-of-sleep-medicine-physician-perceptions-on-the-surgical-treatment-of-obstructive-sleep-apnea
#5
Jonathan J Swope, Marcus A Couey, James W Wilson, Jonathon S Jundt
PURPOSE: Surgical treatment for obstructive sleep apnea (OSA) varies by specialty. Our survey sought to answer 3 principal questions: 1) To which surgical specialists are sleep physicians referring patients for upper airway surgery? 2) Which surgical treatment do sleep specialists find to be most effective in treating OSA? 3) Do sleep medicine physicians believe that maxillomandibular advancement (MMA) is worthwhile to patients who are surgical candidates? MATERIALS AND METHODS: We formulated a cross-sectional survey...
December 18, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28062177/maxillomandibular-advancement-for-obstructive-sleep-apnea-syndrome-treatment-long-term-results
#6
Aurélie Vigneron, Renaud Tamisier, Emmanuelle Orset, Jean-Louis Pepin, Georges Bettega
PURPOSE: We evaluated the long term effectiveness of maxillomandibular advancement (MMA) for OSAS treatment patients. This retrospective study reviewed the patients treated by MMA for OSAS between 1995 and 2009. They were evaluated by complete polysomnography, cephalometry and quality of life questionnaire. The minimum follow up was 3 years. Success rate was defined by an IAH <10 with at least a 50% reduction. MATERIAL AND METHODS: 88 patients had MMA during this period...
December 7, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28055280/spatiotemporal-patterns-of-childhood-asthma-hospitalization-and-utilization-in-memphis-metropolitan-area-from-2005-to-2015
#7
Tonny J Oyana, Pradeep Podila, Jagila Minso Wesley, Slawo M Lomnicki, Stephania A Cormier
OBJECTIVE: To identify key risk factors and explain spatiotemporal patterns of childhood asthma in the Memphis Metropolitan Area (MMA) over an 11-year period (2005 to 2015). We hypothesize that in the MMA region this burden is more prevalent among urban children living south, downtown, and north of Memphis than other areas. METHODS: We used a large-scale longitudinal electronic health record database from an integrated healthcare system, GIS, statistical, and space-time models to study spatiotemporal distributions of childhood asthma at census-tract level...
January 5, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28054716/arsenic-resistance-genes-of-as-resistant-purple-nonsulfur-bacteria-isolated-from-as-contaminated-sites-for-bioremediation-application
#8
Phitthaya Nookongbut, Duangporn Kantachote, Kannan Krishnan, Mallavarapu Megharaj
This study aimed to identify arsenic resistant mechanisms in As-resistant purple nonsulfur bacteria (PNSB) by screening them for presence of As-resistance genes and related enzymes. Resistance to As(III) and As(V) of four As-resistant PNSB determined in terms of median inhibition concentration (IC50 values) were in the order of strains Rhodopseudomonas palustris C1 > R. palustris AB3 > Rubrivivax benzoatilyticus C31 > R. palustris L28 which corresponded to the presence of As-resistance genes in these bacteria...
January 5, 2017: Journal of Basic Microbiology
https://www.readbyqxmd.com/read/28052884/vitamin-b-12-fortified-toothpaste-improves-vitamin-status-in-vegans-a-12-wk-randomized-placebo-controlled-study
#9
Anne-Kathrin Siebert, Rima Obeid, Stine Weder, Hussain M Awwad, Andreas Sputtek, Juergen Geisel, Markus Keller
BACKGROUND: The oral application of vitamin B-12 may prevent its deficiency if the vitamin is absorbed via the mucosal barrier. OBJECTIVES: We studied the effect of the use of a vitamin B-12-fortified toothpaste on vitamin-status markers in vegans and assessed the efficiency of markers in the identification of vitamin-augmentation status. DESIGN: In this 12-wk, double-blinded, randomized, placebo-controlled study, 76 vegans received either a placebo (n = 34) or vitamin B-12 (n = 42) toothpaste...
January 4, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28050720/indocyanine-green-visualization-of-middle-meningeal-artery-before-craniotomy-during-surgical-revascularization-for-moyamoya-disease
#10
Nozomu Tanabe, Shusuke Yamamoto, Daina Kashiwazaki, Naoki Akioka, Naoya Kuwayama, Kyo Noguchi, Satoshi Kuroda
BACKGROUND: The middle meningeal artery (MMA) is well known to function as an important collateral channel to the territory of the anterior cerebral artery in moyamoya disease. This study was aimed to evaluate whether indocyanine green (ICG) videoangiography could visualize the anterior branch of the MMA before craniotomy during surgical revascularization for moyamoya disease. METHODS: This study included 19 patients who developed TIA, ischemic stroke or hemorrhagic stroke due to moyamoya disease...
January 3, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28042453/design-and-synthesis-of-selective-small-molecule-inhibitors-of-coactivator-associated-arginine-methyltransferase-1-carm1
#11
H Ü Kaniskan, M S Eram, J Liu, D Smil, M L Martini, Y Shen, V Santhakumar, P J Brown, C Arrowsmith, M Vedadi, J Jin
Coactivator-associated arginine methyltransferase 1 (CARM1) is a type I protein arginine methyltransferase (PRMT) that catalyzes the conversion of arginine into monomethylarginine (MMA) and further into asymmetric dimethylarginine (ADMA). CARM1 methylates histone 3 arginines 17 and 26, as well as numerous non-histone proteins including CBP/p300, SRC-3, NCOA2, PABP1, and SAP49, while also functioning as a coactivator for various proteins that have been linked to cancer such as p53, NF-κβ, β-catenin, E2F1 and steroid hormone receptor ERα...
September 1, 2016: MedChemComm
https://www.readbyqxmd.com/read/28032134/arsenic-speciation-in-organisms-from-two-large-shallow-freshwater-lakes-in-china
#12
Fen Yang, Nan Zhang, Chaoyang Wei, Jinxin Liu, Shaowen Xie
This study measured the elemental and species concentrations of arsenic (As) in the water, sediments and food webs of two shallow Chinese freshwater lakes. Organic As species were widely detected in various organisms from the two lakes (60%-100% of the total). Among these organisms, dimethylarsinic acid (DMA) was predominant in most of the samples. The average concentrations and corresponding proportions were 0.59 mg/kg, 81% in fish; 3.24 mg/kg, 70.63% in zoobenthos; and 1.34 mg/kg, 79% in plants. The average concentrations and corresponding proportions of monomethylarsonic acid (MMA) and inorganic As were much lower, ranging from n...
December 28, 2016: Bulletin of Environmental Contamination and Toxicology
https://www.readbyqxmd.com/read/28008353/impact-of-medicare-part-d-on-racial-and-ethnic-minorities
#13
JoEllen Jarrett Jamison, Junling Wang, Satya Surbhi, Samantha Adams, David Solomon, Kenneth C Hohmeier, Sharon McDonough, James C Eoff
OBJECTIVES: Prior to the implementation of Medicare Part D in the United States, inequalities were found to exist in the use of medications between minority and white beneficiaries. Despite improvements in medication affordability after Medicare Part D implementation, it is still not clear whether the characteristics of the program have improved drug utilization patterns among minorities to the same degree as whites. This review aims to determine whether there were barriers for Medicare Part D to realize its potential to improve prescription drug utilization patterns among minorities...
2016: Diversity and Equality in Health and Care
https://www.readbyqxmd.com/read/28007985/dose-response-relationship-between-inorganic-arsenic-exposure-and-lung-cancer-among-arseniasis-residents-with-low-methylation-capacity
#14
Kuang-Hung Hsu, Ke-Hung Tsui, Ling-I Hsu, Hung-Yi Chiou, Chien-Jen Chen
Background Exposure to inorganic arsenic (InAs) has been documented as a risk factor for lung cancer. This study examined the association between InAs exposure, its metabolism, and lung cancer occurrence. Methods We followed 1300 residents from an arseniasis area in Taiwan, determined urinary InAs metabolites, and identified 39 lung cancer cases. Cox proportional hazard model was performed. Results The results demonstrated that participants with either the primary methylation index (monomethylarsonic acid [MMA]/InAs) or the secondary methylation index (dimethylarsinic acid[DMA]/MMA) lower than their respective median values were at a higher risk of lung cancer (hazard ratios from 3...
December 22, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28007395/preparation-and-characterization-of-high-radio-opaque-e-glass-fiber-reinforced-composite-with-iodine-containing-methacrylate-monomer
#15
Jingwei He, Pekka K Vallittu, Lippo V Lassila
OBJECTIVE: The purpose of this study was to prepare radio-opaque E-glass fiber-reinforced composite (EFRC) with synthesized iodine containing methacrylate monomer. METHODS: The synthesized iodine containing methacrylate monomer 2-hydroxy-3- methacryloyloxypropyl(2,3,5- triiodobenzoate) (HMTIB) was mixed with Bis-GMA and MMA in different mass ratio to prepare resin impregnating solution (RIS), and RIS without HMTIB was used as control. CQ and DMAEMA were added as photoinitiation system...
December 19, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28007181/methylated-and-thiolated-arsenic-species-for-environmental-and-health-research-a-review-on-synthesis-and-characterization
#16
REVIEW
William R Cullen, Qingqing Liu, Xiufen Lu, Anthony McKnight-Whitford, Hanyong Peng, Aleksandra Popowich, Xiaowen Yan, Qi Zhang, Michael Fricke, Hongsui Sun, X Chris Le
Hundreds of millions of people around the world are exposed to elevated concentrations of inorganic and organic arsenic compounds, increasing the risk of a wide range of health effects. Studies of the environmental fate and human health effects of arsenic require authentic arsenic compounds. We summarize here the synthesis and characterization of more than a dozen methylated and thiolated arsenic compounds that are not commercially available. We discuss the methods of synthesis for the following 14 trivalent (III) and pentavalent (V) arsenic compounds: monomethylarsonous acid (MMA(III)), dicysteinylmethyldithioarsenite (MMA(III)(Cys)2), monomethylarsonic acid (MMA(V)), monomethylmonothioarsonic acid (MMMTA(V)) or monothio-MMA(V), monomethyldithioarsonic acid (MMDTA(V)) or dithio-MMA(V), monomethyltrithioarsonate (MMTTA(V)) or trithio-MMA(V), dimethylarsinous acid (DMA(III)), dimethylarsino-glutathione (DMA(III)(SG)), dimethylarsinic acid (DMA(V)), dimethylmonothioarsinic acid (DMMTA(V)) or monothio-DMA(V), dimethyldithioarsinic acid (DMDTA(V)) or dithio-DMA(V), trimethylarsine oxide (TMAO(V)), arsenobetaine (AsB), and an arsenicin-A model compound...
November 2016: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28007171/arsenic-methylation-by-an-arsenite-s-adenosylmethionine-methyltransferase-from-spirulina-platensis
#17
Yuqing Guo, Ximei Xue, Yu Yan, Yongguan Zhu, Guidi Yang, Jun Ye
Arsenic-contaminated water is a serious hazard for human health. Plankton plays a critical role in the fate and toxicity of arsenic in water by accumulation and biotransformation. Spirulina platensis (S. platensis), a typical plankton, is often used as a supplement or feed for pharmacy and aquiculture, and may introduce arsenic into the food chain, resulting in a risk to human health. However, there are few studies about how S. platensis biotransforms arsenic. In this study, we investigated arsenic biotransformation by S...
November 2016: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28007166/comparative-cytotoxicity-of-fourteen-trivalent-and-pentavalent-arsenic-species-determined-using-real-time-cell-sensing
#18
Birget Moe, Hanyong Peng, Xiufen Lu, Baowei Chen, Lydia W L Chen, Stephan Gabos, Xing-Fang Li, X Chris Le
The occurrence of a large number of diverse arsenic species in the environment and in biological systems makes it important to compare their relative toxicity. The toxicity of arsenic species has been examined in various cell lines using different assays, making comparison difficult. We report real-time cell sensing of two human cell lines to examine the cytotoxicity of fourteen arsenic species: arsenite (As(III)), monomethylarsonous acid (MMA(III)) originating from the oxide and iodide forms, dimethylarsinous acid (DMA(III)), dimethylarsinic glutathione (DMAG(III)), phenylarsine oxide (PAO(III)), arsenate (As(V)), monomethylarsonic acid (MMA(V)), dimethylarsinic acid (DMA(V)), monomethyltrithioarsonate (MMTTA(V)), dimethylmonothioarsinate (DMMTA(V)), dimethyldithioarsinate (DMDTA(V)), 3-nitro-4-hydroxyphenylarsonic acid (Roxarsone, Rox), and 4-aminobenzenearsenic acid (p-arsanilic acid, p-ASA)...
November 2016: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28005735/subtypes-of-maxillomandibular-advancement-surgery-for-patients-with-obstructive-sleep-apnea
#19
Won-June Lee, Dong-Hyun Hwang, Stanley Yung-Chuan Liu, Su-Jung Kim
Maxillomandibular advancement (MMA) surgery, which is the most effective treatment modality for patients with moderate-to-severe obstructive sleep apnea with apparent skeletal discrepancies, has been modified in conjunction with segmental osteotomies, counterclockwise rotation of maxillomandibular complex, and other adjunctive procedures. However, any single type of MMA could not treat or cure all the patients with obstructive sleep apnea showing different dentofacial and pharyngeal patterns. We aimed to suggest critical decision factors for the selective application of MMA subtypes, categorized as straight MMA with genioplasty, rotational MMA, segmental MMA, and segmental-rotational MMA, in the surgical treatment objective process: anteroposterior position of maxilla, upper lip projection, overjet, lower incisor inclination as sagittal factors, and upper incisor exposure and occlusal plane angle as vertical factors...
November 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28004494/photochemically-induced-atrp-of-meth-acrylates-in-the-presence-of-air-the-effect-of-light-intensity-ligand-and-oxygen-concentration
#20
Katarína Borská, Daniela Moravčíková, Jaroslav Mosnáček
Well-defined poly(methyl methacrylate) (PMMA) and poly(methyl acrylate) (PMA) are prepared via photochemically induced atom transfer radical polymerization (photoATRP) using ppm amounts of CuBr2 /tris(2-pyridylmethyl)amine and CuBr2 /tris[2-(dimethylamino)ethyl]amine catalyst complexes, respectively, without degassing of polymerization mixture and with no need to introduce an external reducing agent to the system. The effect of ligand to CuBr2 ratio on kinetic and induction period during the polymerization of MMA and MA is investigated...
December 22, 2016: Macromolecular Rapid Communications
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