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https://www.readbyqxmd.com/read/29688272/cellular-plasticity-in-the-adult-murine-piriform-cortex-continuous-maturation-of-dormant-precursors-into-excitatory-neurons
#1
Peter Rotheneichner, Maria Belles, Bruno Benedetti, Richard König, Dominik Dannehl, Christina Kreutzer, Pia Zaunmair, Maren Engelhardt, Ludwig Aigner, Juan Nacher, Sebastien Couillard-Despres
Neurogenesis in the healthy adult murine brain is based on proliferation and integration of stem/progenitor cells and is thought to be restricted to 2 neurogenic niches: the subventricular zone and the dentate gyrus. Intriguingly, cells expressing the immature neuronal marker doublecortin (DCX) and the polysialylated-neural cell adhesion molecule reside in layer II of the piriform cortex. Apparently, these cells progressively disappear along the course of ageing, while their fate and function remain unclear...
April 21, 2018: Cerebral Cortex
https://www.readbyqxmd.com/read/29687359/does-apneic-oxygenation-prevent-desaturation-during-emergency-airway-management-a-systematic-review-and-meta-analysis
#2
Edmund Tan, Osama Loubani, Nelofar Kureshi, Robert S Green
RéSUMé: OBJECTIF: L'oxygénation apnéique (OA) par lunettes nasales est une méthode de prévention de la désaturation en oxygène au cours des intubations en urgence. L'objectif de cette revue systématique était de déterminer l'efficacité de l'OA sur la prévention de la désaturation en oxygène au cours des intubations en urgence. SOURCE: Des recherches systématiques ont été effectuées dans trois bases de données électroniques (MEDLINE, EMBASE et CINAHL) pour identifier les études portant sur la prévention de la désaturation en oxygène au moyen de l'OA par lunettes nasales...
April 23, 2018: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/29682257/therapeutic-efficiency-of-platelet-gel-for-the-treatment-of-oral-ulcers-related-to-chronic-graft-versus-host-disease-after-allogeneic-haematopoietic-stem-cell-transplantation
#3
A Picardi, A S Ferraro, M Miranda, F Meconi, A Lanti, G Adorno, W Arcese, P Bollero
Background: Platelet (PLT) gel has been successfully used in tissue regeneration of diabetic and surgical wounds through the releasing of growth factors such as basic fibroblast and PLT-derived growth factors. Based on this background, our previous clinical trial have assessed the feasibility and efficacy of PLT gel for the treatment of muco-cutaneous lesions related to graft versus host disease (GvHD) after allogeneic haematopoietic stem cell transplantion (HSCT). The promising results reported in a small series of 6 patients, of whom 1 with oral ulcers, represent the rationale of the present study...
October 2017: Oral & Implantology
https://www.readbyqxmd.com/read/29681258/treatment-with-cyclic-adenosine-monophosphate-modulators-prior-to-in-vitro-maturation-alters-the-lipid-composition-and-transcript-profile-of-bovine-cumulus-oocyte-complexes-and-blastocysts
#4
Eduardo M Razza, Mateus J Sudano, Patricia K Fontes, Fernanda F Franchi, Katia Roberta A Belaz, Priscila H Santos, Anthony C S Castilho, Daniele F O Rocha, Marcos N Eberlin, Mariana F Machado, Marcelo F G Nogueira
Mammalian oocytes resume meiosis spontaneously after removal from the ovarian follicle. We tested the effects of a 2-h prematuration treatment (Pre-IVM) with forskolin (FSK) and 3-isobutyl-1-methylxanthine (IBMX) in bovine cumulus-oocyte complexes (COCs) on the lipid content of oocytes and blastocysts, on the membrane lipid composition of blastocysts and on the transcriptional profiling of cumulus cells and blastocysts in a high-throughput platform. Embryonic development rates to the morula (mean 56.1%) or blastocyst (mean 26...
April 23, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29680230/percutaneous-ablative-cryoimmunotherapy-for-micrometastaic-abscopal-effect-no-complications
#5
Erik Soule, Mark Bandyk, Jerry Matteo
Recent studies have shown efficacy of nivolumab, a monoclonal antibody specific for an immunoregulatory protein termed programmed death 1 (PD-1), against metastatic renal cell carcinoma. PD-1 is a transmembrane protein expressed on T cells that suppresses activation upon binding to its ligands, which may be secreted paraneoplastically by various cancers. Inhibition of PD-1 signaling via nivolumab may sensitize tumor-specific T lymphocytes in the immunosuppressive tumor microenvironment. Systemic elimination of micrometastases requires robust activation and proliferation of tumor antigen stimulated T cells...
April 19, 2018: Cryobiology
https://www.readbyqxmd.com/read/29678921/a-repeating-sulfated-galactan-motif-resuscitates-dormant-micrococcus-luteus
#6
Thomas Böttcher, Dávid Szamosvári, Jon Clardy
Only a small fraction of bacteria can autonomously initiate growth on agar plates. Non-growing bacteria typically enter a metabolically inactive dormant state and require specific chemical trigger factors or signals to exit this state and resume growth. Micrococcus luteus has become a model organism for this important yet poorly understood phenomenon. So far, only few resuscitation signals have been described and all of them are produced endogenously by bacterial species. We report the discovery of a novel type of resuscitation signal that allows M...
April 20, 2018: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/29676695/huge-heterogeneity-in-survival-in-a-subset-of-adult-patients-with-resected-wild-type-isocitrate-dehydrogenase-status-who-grade-ii-astrocytomas
#7
Gaëtan Poulen, Catherine Gozé, Valérie Rigau, Hugues Duffau
OBJECTIVE World Health Organization grade II gliomas are infiltrating tumors that inexorably progress to a higher grade of malignancy. However, the time to malignant transformation is quite unpredictable at the individual patient level. A wild-type isocitrate dehydrogenase (IDH-wt) molecular profile has been reported as a poor prognostic factor, with more rapid progression and a shorter survival compared with IDH-mutant tumors. Here, the oncological outcomes of a series of adult patients with IDH-wt, diffuse, WHO grade II astrocytomas (AII) who underwent resection without early adjuvant therapy were investigated...
April 20, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29675570/driving-ability-after-right-sided-puncture-of-the-common-femoral-artery-during-coronary-angiography
#8
Christoph Brenner, Raoul Fuehring, David Niederseer, Rudolf Kirchmair, Christian Haid, Michael Liebensteiner
OBJECTIVES/BACKGROUND: To assess brake reaction time (BRT; key factor in driving ability) in patients receiving transfemoral coronary angiography (CAG). We assumed that patients would have a significantly impaired BRT after the procedure. METHODS: A prospective, observational study design was applied. Consecutive patients undergoing right-sided transfemoral CAG as part of the clinical routine were included. An experimental driving simulator was used to determine BRT after receiving a visual stimulus...
April 19, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29674785/effects-of-prolonged-immunocontraception-on-the-breeding-behavior-of-american-bison
#9
Calvin L Duncan, Julie L King, Paul Stapp
In late 2009, the Catalina Island Conservancy began using fertility control to replace periodic removals to manage an introduced population of American bison ( Bison bison ) on the island. Through the application of the immunocontraceptive vaccine porcine zona pellucida (PZP), population growth was slowed within 1 year, and halted over time. In response to lingering questions about the use of PZP to manage large, free-ranging wildlife populations, we sought to determine the reversibility of PZP by ceasing the annual application to a subset of 15 bison cows and monitoring for subsequent calf arrival, and to document changes in the timing and length of the breeding season in response to PZP by monitoring breeding behavior and assessing fecal progesterone (FP) levels for all 60 resident cows over a 13-month period...
October 3, 2017: Journal of Mammalogy
https://www.readbyqxmd.com/read/29672284/induction-of-pluripotent-stem-cell-derived-cardiomyocyte-toxicity-by-supernatant-of-long-term-stored-red-blood-cells-in-vitro
#10
Fengyan Fan, Yang Yu, Liping Sun, Shufang Wang, Rui Wang, Leiying Zhang, Cuiying Li, Deqing Wang
BACKGROUND/AIMS: Preserved red blood cells (RBCs) in vitro undergo a series of morphological, functional and metabolic changes during storage. RBC metabolites accumulate over time during storage, the toxicity of the supernatants of RBCs (SSRBCs) on tissue cells is largely unknown. Here, we aimed to study cardiomyocyte toxicity by supernatant of long term-stored RBCs in vitro and to discover elements involved in the mechanism. METHODS: Using human-induced pluripotent stem cell-derived cardiomyocytes (hiPS-CMs) and real-time cell analyzing (RTCA), we analyzed the cardiotoxicity of d0, d14 and d35 SSRBCs...
April 16, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29671632/r%C3%A3-sum%C3%A3-s-en-fran%C3%A3-ais
#11
(no author information available yet)
No abstract text is available yet for this article.
May 2018: American Journal on Intellectual and Developmental Disabilities
https://www.readbyqxmd.com/read/29671031/short-term-decreased-physical-activity-with-increased-sedentary-behaviour-causes-metabolic-derangements-and-altered-body-composition-effects-in-individuals-with-and-without-a-first-degree-relative-with-type-2-diabetes
#12
Kelly A Bowden Davies, Victoria S Sprung, Juliette A Norman, Andrew Thompson, Katie L Mitchell, Jason C G Halford, Jo A Harrold, John P H Wilding, Graham J Kemp, Daniel J Cuthbertson
AIMS/HYPOTHESIS: Low physical activity levels and sedentary behaviour are associated with obesity, insulin resistance and type 2 diabetes. We investigated the effects of a short-term reduction in physical activity with increased sedentary behaviour on metabolic profiles and body composition, comparing the effects in individuals with first-degree relatives with type 2 diabetes (FDR+ve) vs those without (FDR-ve). METHODS: Forty-five habitually active participants (16 FDR+ve [10 female, 6 male] and 29 FDR-ve [18 female, 11 male]; age 36 ± 14 years) were assessed at baseline, after 14 days of step reduction and 14 days after resuming normal activity...
April 18, 2018: Diabetologia
https://www.readbyqxmd.com/read/29670764/corticosteroid-weaning-in-stable-heart-transplant-patients-guidance-by-serum-cortisol-level
#13
David A Baran, Cheryl Rosenfeld, Mark J Zucker
Background: Despite earlier studies describing the feasibility of steroid weaning in heart transplant patients, the majority of patients are maintained on steroid therapy for life. We examined a strategy based on a single morning serum cortisol measurement. Methods: We assigned stable posttransplant patients, who were maintained on tacrolimus, mycophenolate mofetil, and corticosteroids, into one of two groups based on a screening morning cortisol level. Patients with a cortisol < 8 micrograms/deciliter were assigned to a "maintenance" group and the others were assigned to the weaning group and steroids were tapered off over 4-6 weeks...
2018: Journal of Transplantation
https://www.readbyqxmd.com/read/29668604/sonographic-and-ct-imaging-features-of-intestinal-perforation-from-a-pill-and-packing-a-case-report
#14
Ze-Hui Gou, Yulan Peng, Kun Yang
RATIONALE: Sharp foreign bodies such as toothpicks or chicken bones can lead to intestinal perforation. Small intestinal perforation secondary to foreign body ingestion is usually manifested as an acute abdomen without a history of trauma. Here we describe the diagnosis and treatment of a case of small bowel perforation caused by an ingested pill and its outer packing. PATIENT CONCERNS: An 84 years old male patient complained of right lower abdominal pain for 4 days and the pain was becoming progressively worse...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29664159/reading-aids-for-adults-with-low-vision
#15
REVIEW
Gianni Virgili, Ruthy Acosta, Sharon A Bentley, Giovanni Giacomelli, Claire Allcock, Jennifer R Evans
BACKGROUND: The purpose of low-vision rehabilitation is to allow people to resume or to continue to perform daily living tasks, with reading being one of the most important. This is achieved by providing appropriate optical devices and special training in the use of residual-vision and low-vision aids, which range from simple optical magnifiers to high-magnification video magnifiers. OBJECTIVES: To assess the effects of different visual reading aids for adults with low vision...
April 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29663013/bone-to-bone-integrations-were-complete-within-5-months-after-anatomical-rectangular-tunnel-anterior-cruciate-ligament-reconstruction-using-a-bone-patellar-tendon-bone-graft
#16
Hironari Masuda, Shuji Taketomi, Hiroshi Inui, Naoya Shimazaki, Nobuhiro Nishihara, Seikai Toyooka, Hirotaka Kawano, Takumi Nakagawa
PURPOSE: Anterior cruciate ligament (ACL) reconstruction using a bone-patellar tendon-bone (BTB) graft is known to provide secure fixation due to the direct bone-to-bone integration of the bone plug and bone tunnel. It is important to know the time required for bone integration when designing the postoperative rehabilitation protocol or deciding when the patient can return to competition-level activity, especially if the patient is an athlete. However, because reports are scarce, the period necessary for bone-to-bone integration after ACL reconstruction using a BTB graft remains unclear...
April 16, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29662882/circulatory-arrest-brain-arrest-and-death-determination
#17
Sam David Shemie, Dale Gardiner
Technological advances, particularly in the capacity to support, replace or transplant failing organs, continue to challenge and refine our understanding of human death. Given the ability to reanimate organs before and after death, both inside and outside of the body, through reinstitution of oxygenated circulation, concepts related to death of organs (e.g. cardiac death) are no longer valid. This paper advances the rationale for a single conceptual determination of death related to permanent brain arrest, resulting from primary brain injury or secondary to circulatory arrest...
2018: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29661038/valued-activities-and-informal-caregiving-in-stroke-a-scoping-review
#18
Sandra Jellema, Mandy A M Wijnen, Esther M J Steultjens, Maria W G Nijhuis-van der Sanden, Rob van der Sande
PURPOSE: Map the literature about valued activities and informal caregiving post stroke and determine the nature, extent, and consequences of caregivers' activity changes. METHODS: A scoping review was undertaken, searching Pubmed, Cinahl, PsycInfo, and Google Scholar. Two researchers independently identified relevant articles, extracted study characteristics and findings, and assigned codes describing the topics and outcomes. Using thematic analysis, the main study topics and study outcomes were described...
April 17, 2018: Disability and Rehabilitation
https://www.readbyqxmd.com/read/29658797/physical-activity-during-hospitalization-activities-and-preferences-of-adults-versus-older-adults
#19
Jorit Meesters, D Conijn, H M Vermeulen, Tpm Vliet Vlieland
OBJECTIVE: Inactivity during hospitalization leads to a functional decline and an increased risk of complications. To date, studies focused on older adults. This study aims to compare the physical activities performed by older adult and adult hospitalized patients. METHODS: Patients hospitalized for >3 days at a university hospital completed a questionnaire regarding their physical activities (% of days on which an activity was performed divided by the length of stay) and physical activity needs during hospitalization...
April 16, 2018: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/29658288/canadian-nutrition-society-scientific-abstracts-from-the-9th-annual-scientific-meeting-soci%C3%A3-t%C3%A3-canadienne-de-nutrition-r%C3%A3-sum%C3%A3-s-scientifiques-de-la-9-e-r%C3%A3-union-scientifique-annuelle
#20
(no author information available yet)
No abstract text is available yet for this article.
April 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
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