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https://www.readbyqxmd.com/read/28734523/laparoscopic-choledochoduodenostomy
#1
Adolfo Cuendis-Velázquez, Mario E Trejo-Ávila, Enrique Rosales-Castañeda, Eduardo Cárdenas-Lailson, Martin E Rojano-Rodríguez, Sujey Romero-Loera, Carlos A Sanjuan-Martínez, Mucio Moreno-Portillo
INTRODUCTION: Today's options for biliary bypass procedures, for difficult choledocholithiasis, range from open surgery to laparo-endoscopic hybrid procedures. The aim of this study was to analyze the outcomes of patients with difficult choledocholithiasis treated with laparoscopic choledochoduodenostomy. METHODS: We performed a prospective observational study from March 2011 to June 2016. We included patients with difficult common bile duct stones (recurrent or unresolved by ERCP) in which a biliary bypass procedure was required...
July 19, 2017: Cirugía Española
https://www.readbyqxmd.com/read/28730630/hartmann-s-reversal-a-comparative-study-between-laparoscopic-and-open-approaches
#2
Han Deok Kwak, Jin Kim, Dong Woo Kang, Se-Jin Baek, Jung Myun Kwak, Seon-Hahn Kim
BACKGROUND: A reversal of Hartmann's procedure can be performed using either a laparoscopic or open approach. However, laparoscopic reversal (LR) of Hartmann's procedure is challenging. This study was designed to compare the results between open and laparoscopic approaches. METHODS: This was a retrospective study of prospectively collected data. We analysed 29 patients who received Hartmann's reversal at Korea University Anam Hospital between April 2007 and September 2014...
July 21, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28730315/comparison-of-nellcor%C3%A2-pm1000n-and-masimo-radical-7-%C3%A2-for-detecting-apnea-in-volunteers
#3
Chanatthee Kitsiripant, Tomoko Fukada, Hiroko Iwakiri, Yuri Tsuchiya, Makoto Ozaki, Minoru Nomura
PURPOSE: Although capnography is considered the gold standard for monitoring of ventilation, it may not work accurately in some situations. We compared the performance of two non-invasive continuous respiratory rate (RR) monitors that are alternatives for the detection of respiratory depression. METHODS: Fifty healthy volunteers ≥20 years old were enrolled in this study. After monitoring of the volunteers was started by the Masimo Radical-7(®) and Nellcor™ PM1000N, they breathed at the rate of 12 breaths/min for 3 min and then stopped breathing...
July 20, 2017: Journal of Anesthesia
https://www.readbyqxmd.com/read/28729103/n-o-225-lignes-directrices-quant-%C3%A3-la-prise-en-charge-des-patientes-en-obst%C3%A3-trique-chez-lesquelles-la-pr%C3%A3-sence-du-syndrome-respiratoire-aigu-s%C3%A3-v%C3%A3-re-sras-est-soup%C3%A3-onn%C3%A3-e-ou-probable-et-des-nouveau-n%C3%A3-s-issus-de-ces-patientes
#4
Cynthia Maxwell, Alison McGeer, Kin Fan Young Tai, Mathew Sermer
OBJECTIF: Le présent document résume notre expérience limitée quant à la présence du SRAS pendant la grossesse et suggère des lignes directrices quant à sa prise en charge. ISSUES: Les exposés de cas issus d'Asie laissent entendre que les issues maternelles et fœtales sont aggravées par la présence du SRAS pendant la grossesse. RéSULTATS: Des recherches ont été menées dans Medline afin d'en tirer les articles pertinents publiés en anglais entre 2000 et 2007...
August 2017: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/28727736/persistent-damaged-bases-in-dna-allow-mutagenic-break-repair-in-escherichia-coli
#5
Jessica M Moore, Raul Correa, Susan M Rosenberg, P J Hastings
Bacteria, yeast and human cancer cells possess mechanisms of mutagenesis upregulated by stress responses. Stress-inducible mutagenesis potentially accelerates adaptation, and may provide important models for mutagenesis that drives cancers, host pathogen interactions, antibiotic resistance and possibly much of evolution generally. In Escherichia coli repair of double-strand breaks (DSBs) becomes mutagenic, using low-fidelity DNA polymerases under the control of the SOS DNA-damage response and RpoS general stress response, which upregulate and allow the action of error-prone DNA polymerases IV (DinB), II and V to make mutations during repair...
July 20, 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28727645/retroperitoneal-hemorrhage-after-sacral-neurostimulator-placement-for-urgency-urinary-incontinence
#6
Casey L Kinman, Deslyn T G Hobson, Anubhav Agrawal, Martin S Vyleta, Sean L Francis
Sacral neuromodulation (SNM) is an effective therapy for patients who experience urinary incontinence, idiopathic urinary retention, and fecal incontinence. Although typically a low-risk procedure, rarely, it can be associated with significant hemorrhage. A 61-year-old woman on chronic anticoagulation underwent uncomplicated implantation of SNM for refractory urgency urinary incontinence. Anticoagulation was held on the day of surgery and resumed on postoperative day 1. On postoperative day 2, the patient developed an extensive retroperitoneal hemorrhage...
July 20, 2017: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/28724453/decrease-in-vancomycin-resistant-enterococcus-colonization-after-extensive-renovation-of-a-unit-dedicated-to-the-treatment-of-hematologic-malignancies-and-hematopoietic-stem-cell-transplantation
#7
Clyde D Ford, Michaela A Gazdik Stofer, Jana Coombs, Bert K Lopansri, Brandon J Webb, Gabriela Motyckova, Finn Bo Petersen
OBJECTIVE While a direct relation between hospital construction and concomitant infection rates has been clearly established, few data are available regarding the environmental decontamination effects of renovation in which surfaces are replaced and regarding subsequent infection incidence. DESIGN Retrospective clinical study with vancomycin-resistant Enterococcus (VRE) molecular strain typing and environmental cultures. SETTING A regional referral center for acute leukemia and hematopoietic stem-cell transplantation...
July 20, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/28723516/the-molecular-evolution-of-castration-resistant-prostate-cancer
#8
REVIEW
Yvonne Ceder, Anders Bjartell, Zoran Culig, Mark A Rubin, Scott Tomlins, Tapio Visakorpi
CONTEXT: Androgen deprivation therapy (ADT) is the backbone of treatment for advanced prostate cancer. However, castration-resistant prostate cancer (CRPC) nearly invariably develops through a range of different molecular mechanisms accompanied by progression to a more aggressive phenotype. OBJECTIVE: To understand the key molecular mechanisms leading to CRPC and the functional implications of this progression. Understanding molecular evolutionary mechanisms in CRPC is essential for the development of novel curative therapeutic approaches...
December 2016: European Urology Focus
https://www.readbyqxmd.com/read/28723234/flexible-small-molecular-anti-estrogens-with-n-n-dialkylated-2-5-diethoxy-4-morpholinoaniline-scaffold-targets-multiple-estrogen-receptor-conformations
#9
Bethany K Asare, Emmanuel Yawson, Rajendram V Rajnarayanan
Estrogen mediates various cellular processes including cell proliferation, differentiation, growth and mammary gland function. Estrogen Receptors (ERs) are expressed in 70% of breast cancers. Consequently, estrogen mediated ER signaling plays a critical role in breast cancer diagnosis, prognosis, and treatment. Estrogen Receptors are ligand-triggered transcription factors. However, in the absence of a cognate estrogenic ligand, ERs can be activated by a variety of other extracellular signals. Tamoxifen, an anti-estrogen that selectively targets ER, induces substantial regression of breast tumors and an increase in disease-free survival...
July 19, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28721023/persistence-to-disease-modifying-therapies-for-multiple-sclerosis-in-a-canadian-cohort
#10
Dessalegn Y Melesse, Ruth Ann Marrie, James F Blanchard, Bo Nancy Yu, Charity Evans
PURPOSE: To examine the long-term persistence to the first-line injectable disease-modifying therapies (DMTs) for multiple sclerosis (MS) and to identify the factors associated with nonpersistence. PATIENTS AND METHODS: We used population-based administrative data from Manitoba, Canada. All adult subjects who were diagnosed with MS and dispensed a first-line injectable DMT (beta-interferon-1b, beta-interferon-1a, and glatiramer acetate) between 1996 and 2011 and had a minimum of 1 year of follow-up were included...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28719752/return-to-sport-after-shoulder-arthroplasty-in-recreational-athletes-a-systematic-review-and-meta-analysis
#11
Florence Aim, Jean-David Werthel, Julien Deranlot, Marie Vigan, Geoffroy Nourissat
BACKGROUND: One of the most frequent demands from patients after shoulder replacement surgery is to return to sport. PURPOSE: To determine the rate of return to sport after shoulder arthroplasty (total shoulder arthroplasty, reverse shoulder arthroplasty, hemiarthroplasty) in recreational athletes. STUDY DESIGN: Meta-analysis and systematic review. METHODS: The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines were followed to perform this systematic review and meta-analysis of the results in the literature as well as the presentation of results...
July 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28718590/-novelties-in-ent-2016
#12
Francis Marchal
These novelties in ENT were selected among more than 15'000 abstracts in the 2016 literature, and dedicated to the practioner Guidelines of the American Academy of ORL will resume the attitude towards chronic otitis media, and reviews of hearing impairment and tinnitus are presented, as well as impact of the pneumoccal vaccine on otitis media. In rhinology, the flora of chronic rhinosinusitis and its non surgical treatments will be discussed, as well as epistaxis and malignant tumor series. 17 Diseases dignanosed only with exhaled air will be also reported...
March 8, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28717867/totally-laparoscopic-living-donor-left-hepatectomy-for-liver-transplantation-in-a-child
#13
Helayel Almodhaiberi, Seok-Hwan Kim, Ki-Hun Kim
BACKGROUND: Minimally invasive surgery has been validated to be a new standard in living donor hepatectomy for adult-to-pediatric transplantation with less morbidity [1]. Laparoscopic donor hepatectomy can reduce the major concerns about pain and morbidity associated with open surgery and a slow return to daily activities of donors [2]. Herein, we present one case of totally laparoscopic living donor left hepatectomy including the middle hepatic vein (MHV). DONOR AND METHOD: A 37-year-old mother volunteered to donate to her 3-year-old son with biliary atresia (PELD score 7)...
July 17, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28717614/activity-level-recovery-after-acute-achilles-tendon-rupture-surgically-repaired-a-series-of-29-patients-with-a-mean-follow-up-of-46-months
#14
Richard Zayni, Raphaël Coursier, Moudasser Zakaria, Jean-François Desrousseaux, Denis Cordonnier, Gilles Polveche
BACKGROUND: Achilles tendon rupture is a common injury but its optimal management is still controversial. When decided, surgical repair can be performed by open or percutaneous techniques. Till now, there is no agreement on the ideal type of surgical management. PURPOSE: To compare the outcomes of the percutaneous and open surgical treatment for acute Achilles tendon rupture and to assess the postoperative activity level recovery. METHODS: Between 2008 and 2013, 29 patients were surgically treated for acute Achilles tendon rupture in our institution...
January 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28716933/cortical-actin-recovery-at-the-immunological-synapse-leads-to-termination-of-lytic-granule-secretion-in-cytotoxic-t-lymphocytes
#15
Alex T Ritter, Senta M Kapnick, Sricharan Murugesan, Pamela L Schwartzberg, Gillian M Griffiths, Jennifer Lippincott-Schwartz
CD8(+) cytotoxic T lymphocytes (CTLs) eliminate virally infected cells through directed secretion of specialized lytic granules. Because a single CTL can kill multiple targets, degranulation must be tightly regulated. However, how CTLs regulate the termination of granule secretion remains unclear. Previous work demonstrated that centralized actin reduction at the immune synapse precedes degranulation. Using a combination of live confocal, total internal reflection fluorescence, and superresolution microscopy, we now show that, after granule fusion, actin recovers at the synapse and no further secretion is observed...
July 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28715346/new-prospective-4d-ct-for-mitigating-the-effects-of-irregular-respiratory-motion
#16
Tinsu Pan, Rachael M Martin, Dershan Luo
Artifact caused by irregular respiration is a major source of error in 4D-CT imaging. We propose a new prospective 4D-CT to mitigate this source of error without new hardware, software or off-line data-processing on the GE CT scanner. We utilize the cine CT scan in the design of the new prospective 4D-CT. The cine CT scan at each position can be stopped by the operator when an irregular respiration occurs, and resumed when the respiration becomes regular. This process can be repeated at one or multiple scan positions...
July 17, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28714612/weaning-from-long-term-continuous-positive-airway-pressure-or-noninvasive-ventilation-in-children
#17
Meriem Mastouri, Alessandro Amaddeo, Lucie Griffon, Annick Frapin, Samira Touil, Adriana Ramirez, Sonia Khirani, Brigitte Fauroux
OBJECTIVES: A significant number of children are able to discontinue long term continuous positive airway pressure (CPAP) or noninvasive ventilation (NIV) but the underlying disorders, weaning criteria, and outcome of these children have not been studied. STUDY DESIGN: Retrospective cohort follow up. SUBJECT SELECTION: Consecutive children who were weaned from long term CPAP/NIV between October 2013 and January 2016. METHODOLOGY: Underlying disorders, weaning criteria, and clinical outcome were analyzed...
July 17, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28712826/induction-of-skeletal-abnormalities-and-autophagy-in-paracentrotus-lividus-sea-urchin-embryos-exposed-to-gadolinium
#18
Chiara Martino, Roberto Chiarelli, Liana Bosco, Maria Carmela Roccheri
Gadolinium (Gd) concentration is constantly increasing in the aquatic environment, becoming an emergent environmental pollutant. We investigated the effects of Gd on Paracentrotus lividus sea urchin embryos, focusing on skeletogenesis and autophagy. We observed a delay of biomineral deposition at 24 hours post fertilization (hpf), and a strong impairment of skeleton growth at 48 hpf, frequently displayed by an asymmetrical pattern. Skeleton growth was found partially resumed in recovery experiments. The mesodermal cells designated to biomineralization were found correctly migrated at 24 hpf, but not at 48 hpf...
July 6, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28712792/seasonal-plasticity-of-song-behavior-relies-on-motor-and-syntactic-variability-induced-by-a-basal-ganglia-forebrain-circuit
#19
Jorge Alliende, Nicolas Giret, Ludivine Pidoux, Catherine Del Negro, Arthur Leblois
The plasticity of nervous systems allows animals to quickly adapt to a changing environment. In particular, seasonal plasticity of brain structure and behavior is often critical to survival or mating in seasonal climates. Songbirds provide striking examples of seasonal changes in neural circuits and vocal behavior and have emerged as a leading model for adult brain plasticity. While seasonal plasticity and the well-characterized process of juvenile song learning may share common neural mechanisms, the extent of their similarity remains unclear...
July 13, 2017: Neuroscience
https://www.readbyqxmd.com/read/28712566/left-habenular-activity-attenuates-fear-responses-in-larval-zebrafish
#20
Erik R Duboué, Elim Hong, Kiara C Eldred, Marnie E Halpern
Fear responses are defensive states that ensure survival of an organism in the presence of a threat. Perception of an aversive cue causes changes in behavior and physiology, such as freezing and elevated cortisol, followed by a return to the baseline state when the threat is evaded [1]. Neural systems that elicit fear behaviors include the amygdala, hippocampus, and medial prefrontal cortex. However, aside from a few examples, little is known about brain regions that promote recovery from an aversive event [2]...
July 8, 2017: Current Biology: CB
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