Zhaoyang Li, Ziying Wang, Chao Zhong, Hang Zhang, Rui Liu, Ping An, Zhiqiang Ma, Junmei Lu, Chengfang Pan, Zhaolin Zhang, Zhiyuan Cao, Jianyi Hu, Dong Xing, Yiyan Fei, Yu Ding, Boxun Lu
Molecular glues are typically small chemical molecules that act at the interface between a target protein and degradation machinery to trigger ternary complex formation. Identifying molecular glues is challenging. There is a scarcity of target-specific upregulating molecular glues, which are highly anticipated for numerous targets, including P53. P53 is degraded in proteasomes through polyubiquitination by specific E3 ligases, whereas deubiquitinases (DUBs) remove polyubiquitination conjugates to counteract these E3 ligases...
April 11, 2024: Science Bulletin