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https://www.readbyqxmd.com/read/27933469/telephone-based-mindfulness-therapy-intervention-for-patients-with-chronic-pancreatitis
#1
Vasiliki Irene Aivaliotis, Yvonne Lee, Jasmine Zia, Wahid Wassef, Mark Abramson, Walter Park
BACKGROUND: Patients with chronic pancreatitis (CP) have substantially impaired quality of life (QOL) both physically and mentally. Mindfulness therapy is a form of treatment that has been shown to be beneficial in many medical conditions but has not been evaluated in the CP patient population. AIMS: The aims of this study were (1) to test the feasibility and usability of a novel telephone-based mindfulness therapy service for patients with CP and (2) to determine whether there was any effect on CP quality of life...
December 8, 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/27933338/progress-in-research-and-application-of-hiv-1-tat-derived-cell-penetrating-peptide
#2
REVIEW
Le Zou, Qilin Peng, Ping Wang, Boting Zhou
Human immunodeficiency virus type I (HIV-1) transactivator of transcription (TAT) is encoded by HIV-1. It is a peptide rich in basic amino acids and belongs to the protein transduction domain family. It has been found that HIV-1 TAT and its core peptide segment TAT47-57 play an important role in promoting the cellular uptake of coupled bioactive macromolecules, such as peptides, proteins, oligonucleotides, and drug molecules. HIV-1 TAT can also significantly increase the soluble expression of extrinsic proteins...
December 8, 2016: Journal of Membrane Biology
https://www.readbyqxmd.com/read/27933312/the-genetics-and-epigenetics-of-ptsd-overview-recent-advances-and-future-directions
#3
Christina M Sheerin, Mackenzie J Lind, Kaitlin Bountress, Nicole R Nugent, Ananda B Amstadter
This paper provides a brief summary and commentary on the growing literature and current developments related to the genetic underpinnings of posttraumatic stress disorder (PTSD). We first briefly provide an overview of the behavioral genetic literature on PTSD, followed by a short synopsis of the substantial candidate gene literature with a focus on genes that have been meta-analyzed. We then discuss the genome-wide association studies (GWAS) that have been conducted, followed by an introduction to other molecular platforms used in PTSD genomic studies, such as epigenetic and expression approaches...
April 2017: Current Opinion in Psychology
https://www.readbyqxmd.com/read/27933310/dynamics-of-antigen-presentation-to-transgene-product-specific-cd4-t-cells-and-of-treg-induction-upon-hepatic-aav-gene-transfer
#4
George Q Perrin, Irene Zolotukhin, Alexandra Sherman, Moanaro Biswas, Ype P de Jong, Cox Terhorst, Andrew M Davidoff, Roland W Herzog
The tolerogenic hepatic microenvironment impedes clearance of viral infections but is an advantage in viral vector gene transfer, which often results in immune tolerance induction to transgene products. Although the underlying tolerance mechanism has been extensively studied, our understanding of antigen presentation to transgene product-specific CD4(+) T cells remains limited. To address this, we administered hepatotropic adeno-associated virus (AAV8) vector expressing cytoplasmic ovalbumin (OVA) into wt mice followed by adoptive transfer of transgenic OVA-specific T cells...
2016: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/27933160/post-sensitization-administration-of-non-digestible-oligosaccharides-and-bifidobacterium-breve-m-16v-reduces-allergic-symptoms-in-mice
#5
Betty C A M van Esch, Suzanne Abbring, Mara A P Diks, Gemma M Dingjan, Lucien F Harthoorn, A Paul Vos, Johan Garssen
To support dietary management of severe cow's milk allergic infants, a synbiotic mixture of non-digestible oligosaccharides and Bifidobacterium breve M-16V (B. breve) was designed from source materials that are completely cow's milk-free. It was investigated whether this specific synbiotic concept can reduce an established food allergic response in a research model for hen's egg allergy. Mice were orally sensitized once a week for 5 weeks to ovalbumin (OVA) using cholera toxin (CT) as an adjuvant. Non-sensitized mice received CT in PBS only...
June 2016: Immunity, Inflammation and Disease
https://www.readbyqxmd.com/read/27932997/characterization-of-reproductive-dormancy-in-male-drosophila-melanogaster
#6
Olga I Kubrak, Lucie Kučerová, Ulrich Theopold, Sören Nylin, Dick R Nässel
Insects are known to respond to seasonal and adverse environmental changes by entering dormancy, also known as diapause. In some insect species, including Drosophila melanogaster, dormancy occurs in the adult organism and postpones reproduction. This adult dormancy has been studied in female flies where it is characterized by arrested development of ovaries, altered nutrient stores, lowered metabolism, increased stress and immune resistance and drastically extended lifespan. Male dormancy, however, has not been investigated in D...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27932979/madagascine-induces-vasodilatation-via-activation-of-ampk
#7
Dapeng Chen, Bochao Lv, Sei Kobayashi, Yongjian Xiong, Pengyuan Sun, Yuan Lin, Salvatore Genovese, Francesco Epifano, Shanshan Hou, Fusheng Tang, Yunyan Ji, Dandan Yu
Madagascine (3-isopentenyloxyemodin) can be chemically synthesized or purified from several Rhamnus species, and it is found to have more potent biological activities than the parent compound emodin. The aim of this study is to characterize the vasodilatory effect of madagascine on vasoconstriction and sphingosylphosphorylcholine induced vasospasm in ex vivo and reveal the potential mechanisms in vitro. The effects of madagascine on vasoconstriction of rat mesenteric resistance arteries (MRAs) induced by K(+), methoxamine, and endothelin-1 were, respectively, studied...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27932954/neuronal-release-of-cytokine-il-3-triggered-by-mechanosensitive-autostimulation-of-the-p2x7-receptor-is-neuroprotective
#8
Jason C Lim, Wennan Lu, Jonathan M Beckel, Claire H Mitchell
Mechanical strain due to increased pressure or swelling activates inflammatory responses in many neural systems. As cytokines and chemokine messengers lead to both pro-inflammatory and neuroprotective actions, understanding the signaling patterns triggered by mechanical stress may help improve overall outcomes. While cytokine signaling in neural systems is often associated with glial cells like astrocytes and microglia, the contribution of neurons themselves to the cytokine response is underappreciated and has bearing on any balanced response...
2016: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/27932890/high-expression-of-hmga2-predicts-poor-survival-in-patients-with-clear-cell-renal-cell-carcinoma
#9
Ning Na, Tujie Si, Zhengyu Huang, Bin Miao, Liangqing Hong, Heng Li, Jiang Qiu, Jianguang Qiu
High-mobility group AT-hook 2 (HMGA2) is involved in a wide spectrum of biological processes and is upregulated in several tumors, but its role in renal carcinoma remains unclear. The aim of this study was to examine the expression of HMGA2 and its relationship to the overall survival (OS) of patients with non-metastatic clear cell renal cell carcinoma (ccRCC) following surgery. The expression of HMGA2 was evaluated retrospectively by immunohistochemistry (IHC) in 162 patients with ccRCC who underwent nephrectomy in 2003 and 2004...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27932634/a-narrative-review-of-the-literature-about-people-with-intellectual-disability-who-identify-as-lesbian-gay-bisexual-transgender-intersex-or-questioning
#10
Nathan J Wilson, Jemima Macdonald, Brenda Hayman, Alexandra M Bright, Patsie Frawley, Gisselle Gallego
This narrative review of the research literature presents a summary about the key issues facing people with intellectual disability (ID) who identify as lesbian, gay, bisexual, transgender, intersex or questioning (LGBTIQ). The aim of this review was to consolidate research of the topic; to identify whether any pilot studies reporting social/sexual/educational interventions had been published; and to offer some perspective on the type of future research required to better inform policy, practice and theory that may lead to better outcomes for people with ID who identify as LGBTIQ...
December 8, 2016: Journal of Intellectual Disabilities: JOID
https://www.readbyqxmd.com/read/27932556/orally-administered-berberine-modulates-hepatic-lipid-metabolism-by-altering-microbial-bile-acid-metabolism-and-the-intestinal-fxr-signaling-pathway
#11
Runbin Sun, Na Yang, Bo Kong, Bei Cao, Dong Feng, Xiaoyi Yu, Chun Ge, Jingqiu Huang, Jianliang Shen, Pei Wang, Siqi Feng, Fei Fei, Jiahua Guo, Jun He, Nan Aa, Qiang Chen, Yang Pan, Justin D Schumacher, Chung S Yang, Grace L Guo, Jiye Aa, Guangji Wang
Previous studies suggest that the lipid-lowering effect of BBR involves actions on the LDL receptor and the AMPK signaling pathways. However, the implication of these mechanisms is unclear because of the low bioavailability of BBR. Because the main action site of BBR is the gut and intestinal FXR plays a pivotal role in the regulation of lipid metabolism, we hypothesized that the effects of BBR on intestinal FXR signaling pathway might account for its pharmacological effectiveness. Using wild type (WT) and intestine-specific FXR knockout (FXRint-/-) mice, we found that BBR prevented the development of high-fat-diet induced obesity and ameliorated triglyceride accumulation in livers of WT, but not FXRint-/- mice...
December 8, 2016: Molecular Pharmacology
https://www.readbyqxmd.com/read/27932343/influence-of-the-day-care-home-and-neighbourhood-environment-on-young-children-s-physical-activity-and-health-protocol-for-the-playce-observational-study
#12
Hayley Christian, Clover Maitland, Stephanie Enkel, Georgina Trapp, Stewart G Trost, Jasper Schipperijn, Bryan Boruff, Leanne Lester, Michael Rosenberg, Stephen R Zubrick
INTRODUCTION: The early years are a critical period in a child's health and development, yet most preschool children fail to meet physical activity guidelines. Outside of the home and neighbourhood, children spend a large proportion of time within early childhood education and care (ECEC) services such as long day care. Research is required to determine how the design of day care outdoor (and indoor) spaces provides opportunities or constraints for physical activity. A significant evidence gap surrounds what objectively measured attributes of the home and neighbourhood environment influence preschoolers' physical activity...
December 8, 2016: BMJ Open
https://www.readbyqxmd.com/read/27932341/older-patient-considering-treatment-for-advanced-renal-disease-protocol-for-a-scoping-review-of-the-information-available-for-shared-decision-making
#13
Rajesh Raj, Kiran D K Ahuja, Mai Frandsen, Matthew Jose
INTRODUCTION: Older adults constitute the largest group of patients on dialysis in most parts of the world. Management of advanced renal disease in the older adult is complex; treatment outcomes and prognosis can be markedly different from younger patients. Clinical teams caring for such patients are often called on to provide information regarding prognosis and outcomes with treatment-particularly, the comparison between having dialysis treatment versus not having dialysis. These discussions can be difficult for clinicians because they have to contend with incomplete or nascent data regarding prognosis and outcomes in this age group...
December 8, 2016: BMJ Open
https://www.readbyqxmd.com/read/27932317/end-of-life-care-for-infants-children-and-young-people-with-life-limiting-conditions-summary-of-nice-guidance
#14
Gemma Villanueva, M Stephen Murphy, David Vickers, Emily Harrop, Katharina Dworzynski
No abstract text is available yet for this article.
December 8, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27932069/quercetin-attenuates-vascular-calcification-by-inhibiting-oxidative-stress-and-mitochondrial-fission
#15
Lei Cui, Zhong Li, Xueying Chang, Guangting Cong, Lirong Hao
Vascular calcification is a strong independent predictor of increased cardiovascular morbidity and mortality and has a high prevalence among patients with chronic kidney disease. The present study investigated the effects of quercetin on vascular calcification caused by oxidative stress and abnormal mitochondrial dynamics both in vitro and in vivo. Calcifying vascular smooth muscle cells (VSMCs) treated with inorganic phosphate (Pi) exhibited mitochondrial dysfunction, as demonstrated by decreased mitochondrial potential and ATP production...
December 5, 2016: Vascular Pharmacology
https://www.readbyqxmd.com/read/27931925/investigating-interactions-between-uk-horse-owners-and-prescribers-of-anthelmintics
#16
Stephanie Easton, Gina L Pinchbeck, Thomas Tzelos, David J Bartley, Emily Hotchkiss, Jane E Hodgkinson, Jacqueline B Matthews
Helminths are common pathogens of equids and anthelmintic resistance is a major issue in cyathostomin species and Parascaris equorum. At the heart of mitigating the impact of increasing anthelmintic resistance levels, is the responsible dissemination and use of these medicines following best practice principles. There is a paucity of information on interactions between horse owners and anthelmintic prescribers and how this shapes control. Here, a study was undertaken to determine opinions and experiences of horse owners as they relate to anthelmintics purchase and implementation of best practice control...
December 1, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27931853/from-the-bedside-to-the-bench-new-discoveries-on-blood-cell-fate-and-function
#17
REVIEW
Eirini Trompouki, Eugenia Flores-Figueroa, Daniel Lucas, Teresa Bowman
CONTROVERSY AND CONTEXT: two words that exemplified this year's ISEH meeting. Leaders in the field of hematology from around the world gathered in San Diego in August 2016 to discuss cutting edge research on diverse topics, such as hemoglobin switching, HSC emergence, leukemogenesis, and aging. Major questions discussed included the "when, where, and how" of hematopoietic emergence, bone marrow residence, and disease origination. This meeting summary covers some of the conference highlights.
December 5, 2016: Experimental Hematology
https://www.readbyqxmd.com/read/27931811/the-pigret-assay-a-method-for-measuring-pig-a-gene-mutation-in-reticulocytes-is-reliable-as-a-short-term-in-vivo-genotoxicity-test-summary-of-the-mms-jems-collaborative-study-across-16-laboratories-using-24-chemicals
#18
Takafumi Kimoto, Katsuyoshi Horibata, Daishiro Miura, Satsuki Chikura, Yuki Okada, Akiko Ukai, Satoru Itoh, Shiho Nakayama, Hisakazu Sanada, Naomi Koyama, Shigeharu Muto, Yoshifumi Uno, Mika Yamamoto, Yuta Suzuki, Takayuki Fukuda, Ken Goto, Kunio Wada, Takahiro Kyoya, Miyuki Shigano, Hironao Takasawa, Shuichi Hamada, Hideki Adachi, Yasuaki Uematsu, Eri Tsutsumi, Hisako Hori, Ryuta Kikuzuki, Yosuke Ogiwara, Ikuma Yoshida, Akihisa Maeda, Kazunori Narumi, Yohei Fujiishi, Takeshi Morita, Masami Yamada, Masamitsu Honma
The in vivo mutation assay using the X-linked phosphatidylinositol glycan class A gene (Pig-a in rodents, PIG-A in humans) is a promising tool for evaluating the mutagenicity of chemicals. Approaches for measuring Pig-a mutant cells have focused on peripheral red blood cells (RBCs) and reticulocytes (RETs) from rodents. The recently developed PIGRET assay is capable of screening >1×10(6) RETs for Pig-a mutants by concentrating RETs in whole blood prior to flow cytometric analysis. Additionally, due to the characteristics of erythropoiesis, the PIGRET assay can potentially detect increases in Pig-a mutant frequency (MF) sooner after exposure compared with a Pig-a assay targeting total RBCs (RBC Pig-a assay)...
November 15, 2016: Mutation Research
https://www.readbyqxmd.com/read/27931651/effects-of-vasodilators-on-haemodynamic-coherence
#19
REVIEW
Christian Fuchs, Christian Ertmer, Sebastian Rehberg
Vasodilators are a potential therapeutic option for patients with persisting microcirculatory disorders despite adequate cardiac output and mean arterial pressure due to conventional haemodynamic stabilization. Venous vasodilation may decrease post-capillary venular pressure and thus increase capillary flow resulting in reduced extravasation and oedema formation. Arteriolar vasodilation may increase microvascular flow by 'opening' the microcirculation. In particular, inodilators that combine vasodilation with positive inotropy may be promising...
December 2016: Best Practice & Research. Clinical Anaesthesiology
https://www.readbyqxmd.com/read/27931650/effect-of-non-adrenergic-vasopressors-on-macro-and-microvascular-coupling-in-distributive-shock
#20
REVIEW
M Hessler, T G Kampmeier, S Rehberg
The present review initially describes the rationale for the use of non-adrenergic vasopressors in the treatment of distributive shock and then provides an overview of the individual vasopressin-receptor agonists, namely arginine vasopressin, terlipressin, and selepressin. Following a brief summary of their current use in clinical practice, the present review focuses on the influence of vasopressin-receptor agonists on macro- and microvascular coupling, also referred to as hemodynamic coherence. On the basis of the current evidence from experimental and clinical studies, vasopressin-receptor agonists do not negatively influence macro- and microvascular coupling as compared to the standard therapy with norepinephrine, when used in established treatment regimes...
December 2016: Best Practice & Research. Clinical Anaesthesiology
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