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https://www.readbyqxmd.com/read/28222278/the-enigma-of-traumatic-pseudolipoma-and-traumatic-herniation-of-buccal-fat-pad-a-systematic-review-and-new-classification-system-of-post-traumatic-craniofacial-fatty-masses
#1
Ankeeta Satish Khadilkar, Ashima Goyal, Krishan Gauba
PURPOSE: Intraoral traumatic herniation of the buccal fat pad has been reported using various terms such as traumatic pseudolipoma, traumatic prolapse of buccal fat pad, and traumatic avulsion of buccal fat pad. Because there is no uniformity in nomenclature, this condition needs to be distinguished from other entities such as post-traumatic pseudolipoma and lipoma and pseudoherniation of the buccal fat pad. MATERIALS AND METHODS: A systematic review and thorough search of the literature was planned in online databases such as PubMed, Medline, Scopus, Embase, and Google Scholar...
February 1, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28222094/housing-improvements-and-malaria-risk-in-sub-saharan-africa-a-multi-country-analysis-of-survey-data
#2
Lucy S Tusting, Christian Bottomley, Harry Gibson, Immo Kleinschmidt, Andrew J Tatem, Steve W Lindsay, Peter W Gething
BACKGROUND: Improvements to housing may contribute to malaria control and elimination by reducing house entry by malaria vectors and thus exposure to biting. We tested the hypothesis that the odds of malaria infection are lower in modern, improved housing compared to traditional housing in sub-Saharan Africa (SSA). METHODS AND FINDINGS: We analysed 15 Demographic and Health Surveys (DHS) and 14 Malaria Indicator Surveys (MIS) conducted in 21 countries in SSA between 2008 and 2015 that measured malaria infection by microscopy or rapid diagnostic test (RDT)...
February 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28222068/inhibition-of-cdk5-induces-cell-death-of-tumor-initiating-cells
#3
Melanie M Mandl, Siwei Zhang, Melanie Ulrich, Elisa Schmoeckel, Doris Mayr, Angelika M Vollmar, Johanna Liebl
BACKGROUND: Tumour-initiating cells (TICs) account for chemoresistance, tumour recurrence and metastasis, and therefore represent a major problem in tumour therapy. However, strategies to address TICs are limited. Recent studies indicate Cdk5 as a promising target for anti-cancer therapy and Cdk5 has recently been associated with epithelial-mesenchymal transition (EMT). However, a role of Cdk5 in TICs has not been described yet. METHODS: Expression of Cdk5 in human cancer tissue was analysed by staining of a human tissue microarray (TMA)...
February 21, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28222036/vascular-risk-factors-are-associated-with-retinal-arteriolar-narrowing-and-venular-widening-in-children-and-adolescents-with-type-1-diabetes
#4
Stuart Keel, Catherine Itsiopoulos, Konstandina Koklanis, Meri Vukicevic, Fergus Cameron, Laima Brazionis
BACKGROUND: The aim of the study was to describe the relationship of retinal arteriolar and venular calibre with vascular risk factors in children and adolescents with type 1 diabetes. METHODS: In this hospital-based cross-sectional study, the medical files of 483 children and adolescents with type 1 diabetes were audited to collect retinal images and relevant clinical data. Retinal vascular calibre was measured using standardised protocols. RESULTS: After multivariable adjustments, a vascular risk profile that included: older age, higher serum creatinine, higher systolic blood pressure (SBP), higher body mass index (BMI), abnormal estimated glomerular filtration rate (eGFR), lower high-density lipoproteins (HDL) cholesterol, longer duration of diabetes and higher serum sodium was associated with narrower central retinal artery equivalent (CRAE) (95% CI=-4...
February 21, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28221896/accuracy-and-thoroughness-of-treatment-summaries-provided-as-part-of-survivorship-care-plans-prepared-by-two-cancer-centers
#5
Amye J Tevaarwerk, William G Hocking, Jamie L Zeal, Mindy Gribble, Lori Seaborne, Kevin A Buhr, Kari B Wisinski, Mark E Burkard, Douglas A Wiegmann, Mary E Sesto
PURPOSE: Treatment summaries prepared as part of survivorship care planning should correctly and thoroughly report diagnosis and treatment information. METHODS: As part of a clinical trial, summaries were prepared for patients with stage 0 to III breast cancer at two cancer centers. Summaries were prepared per the standard of care at each center via two methods: using the electronic health record (EHR) to create and facilitate autopopulation of content or using manual data entry into an external software program to create the summary...
February 21, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28221893/summary-of-the-workshop-on-the-safe-handling-of-hazardous-drugs-cohosted-by-the-national-institute-for-occupational-safety-and-health-and-the-american-society-of-clinical-oncology
#6
Thomas H Connor, Paul Celano, James N Frame, Robin T Zon
No abstract text is available yet for this article.
February 21, 2017: Journal of Oncology Practice
https://www.readbyqxmd.com/read/28221018/low-efficiency-upconversion-nanoparticles-for-high-resolution-coalignment-of-near-infrared-and-visible-light-paths-on-a-light-microscope
#7
Sriramkumar Sundaramoorthy, Adrian Garcia Badaracco, Sophia M Hirsch, Jun Hong Park, Tim Davies, Julien Dumont, Mimi Shirasu-Hiza, Andrew C Kummel, Julie C Canman
The combination of near-infrared (NIR) and visible wavelengths in light microscopy for biological studies is increasingly common. For example, many fields of biology are developing the use of NIR for optogenetics, in which an NIR laser induces a change in gene expression and/or protein function. One major technical barrier in working with both NIR and visible light on an optical microscope is obtaining their precise coalignment at the imaging plane position. Photon upconverting particles (UCPs) can bridge this gap as they are excited by NIR light but emit in the visible range via an anti-Stokes luminescence mechanism...
February 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28220969/heterojunction-photocatalysts
#8
REVIEW
Jingxiang Low, Jiaguo Yu, Mietek Jaroniec, Swelm Wageh, Ahmed A Al-Ghamdi
Semiconductor-based photocatalysis attracts wide attention because of its ability to directly utilize solar energy for production of solar fuels, such as hydrogen and hydrocarbon fuels and for degradation of various pollutants. However, the efficiency of photocatalytic reactions remains low due to the fast electron-hole recombination and low light utilization. Therefore, enormous efforts have been undertaken to solve these problems. Particularly, properly engineered heterojunction photocatalysts are shown to be able to possess higher photocatalytic activity because of spatial separation of photogenerated electron-hole pairs...
February 21, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28220884/exploration-of-the-role-of-gene-mutations-in-myelodysplastic-syndromes-through-a-sequencing-design-involving-a-small-number-of-target-genes
#9
Feng Xu, Ling-Yun Wu, Qi He, Dong Wu, Zheng Zhang, Lu-Xi Song, You-Shan Zhao, Ji-Ying Su, Li-Yu Zhou, Juan Guo, Chun-Kang Chang, Xiao Li
Novel sequencing designs are necessary to supplement the recognized knowledge of myelodysplastic syndrome (MDS)-related genomic alterations. In this study, we sequenced 28 target genes in 320 Chinese MDS patients but obtained 77.2% of recall factors and 82.8% of genetic abnormalities (including karyotype abnormalities). In addition to known relationships among mutations, some specific chromosomal abnormalities were found to link to specific gene mutations. Trisomy 8 tended to be linked to U2AF1 and ZRSR2 mutations, and 20q- exhibited higher SRSF2/WT1 and U2AF1 mutation frequency...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28220824/the-association-between-health-related-quality-of-life-dietary-satisfaction-and-perceived-food-environment-among-japanese-individuals-with-spinal-cord-injury
#10
K Hata, T Inayama, N Yoshiike
STUDY DESIGN: Cross-sectional. OBJECTIVES: To examine the association between health-related quality of life (HRQOL)/dietary satisfaction and perceived food environment in community-dwelling individuals with spinal cord injury (SCI). SETTING: Members of the Spinal Injuries Japan organization. METHODS: Subjects were 2007 Japanese individuals with SCI. A questionnaire conducted in 2015 included items addressing sociodemographic characteristics, HRQOL, dietary satisfaction and eight perceived food environment items...
February 21, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28220722/life-after-research-misconduct
#11
Kyle L Galbraith
Research misconduct is a serious violation of a scientific community's ethical standards. Scientists who commit research misconduct typically face corrective actions from employers and funding agencies, as well as significant professional stigma. Unfortunately, there is little systematic data about the post-misconduct career of these guilty parties. Through a review of Office of Research Integrity (ORI) case summaries, I identified a pool of 284 researchers who engaged in research misconduct and were subject to ORI corrective actions...
February 2017: Journal of Empirical Research on Human Research Ethics: JERHRE
https://www.readbyqxmd.com/read/28220708/epidemiology-and-antibiotic-sensitivity-of-staphylococcus-aureus-nasal-carriage-in-children-in-hungary
#12
Krisztina Laub, Adrienn Tóthpál, Szilvia Kardos, Orsolya Dobay
The aim of this study was to assess the Staphylococcus aureus nasal carriage rate in healthy children all over Hungary and to specify some risk factors, the antibiotic resistance patterns of the bacteria, and their genetic relatedness. In total, 878 children (aged 3-6 years) were screened at 21 day-care centers in 16 different cities in Hungary, between February 2009 and December 2011. Samples taken from both nostrils were cultured on blood agar, and suspected S. aureus isolates were identified by β-hemolysis, catalase positivity, clump test, and nucA PCR...
February 21, 2017: Acta Microbiologica et Immunologica Hungarica
https://www.readbyqxmd.com/read/28220472/renal-denervation-for-resistant-hypertension
#13
REVIEW
Giuseppe Coppolino, Anna Pisano, Laura Rivoli, Davide Bolignano
BACKGROUND: Resistant hypertension is highly prevalent among the general hypertensive population and the clinical management of this condition remains problematic. Different approaches, including a more intensified antihypertensive therapy, lifestyle modifications, or both, have largely failed to improve patients' outcomes and to reduce cardiovascular and renal risk. As renal sympathetic hyperactivity is a major driver of resistant hypertension, renal sympathetic ablation (renal denervation) has been recently proposed as a possible therapeutic alternative to treat this condition...
February 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28220376/unveiling-the-relative-efficacy-safety-and-tolerability-of-prophylactic-medications-for-migraine-pairwise-and-network-meta-analysis
#14
Aijie He, Dehua Song, Lei Zhang, Chen Li
BACKGROUND: A large number patients struggle with migraine which is classified as a chronic disorder. The relative efficacy, safety and tolerability of prophylactic medications for migraine play a key role in managing this disease. METHODS: We conducted an extensive literature search for popular prophylactic medications that are used for migraine patients. Pairwise meta-analysis and network meta-analysis (NMA) were carried out sequentially for determining the relative efficacy, safety and tolerability of prophylactic medications...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28220373/body-dysmorphic-disorder-history-and-curiosities
#15
Katlein França, Maria Grazia Roccia, David Castillo, Mana ALHarbi, Georgi Tchernev, Anastasia Chokoeva, Torello Lotti, Massimo Fioranelli
Body dysmorphic disorder is a chronic psychiatric disorder characterized by excessive preoccupation with an absent or minimal physical deformity. It causes severe distress and impairs normal functioning. In the last centuries, this disorder has been mentioned in the medical literature by important mental health practitioners by different names, such as "dysmorphophobia" or "dermatologic hypochondriasis". However, not until the last century was it included among the obsessive-compulsive disorders, although its classification has changed over time...
February 20, 2017: Wiener Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28220308/aberrant-expression-of-cdk8-regulates-the-malignant-phenotype-and-associated-with-poor-prognosis-in-human-laryngeal-squamous-cell-carcinoma
#16
MingHua Li, XiaoDan Zhao, Ying Liu, Jun An, Hui Xiao, Chao Wang
CDK8, a member of the transcriptional subtype of the cyclin-dependent kinases (CDKs) family, shows remarkable cancer tissue specific expression profile and rather more selective contribution to the regulation of gene expression levels involved in some signaling pathways. However, the effect of CDK8 on the malignant phenotype of human laryngeal squamous cell carcinoma (LSCC) cells and the potential molecular mechanisms remain unclear. In the present study, we evaluated the expression levels of CDK8 by quantitative real-time reverse-transcriptase polymerase chain reaction (qRT-PCR) and immunohistochemistry in tissue samples of 60 LSCC patients...
February 20, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28220287/the-yield-of-initial-conventional-mri-in-115-cases-of-angiographically-confirmed-spinal-vascular-malformations
#17
Amgad El Mekabaty, Carlos A Pardo, Philippe Gailloud
MRI is the primary screening tool for patients with myelopathy. The decision to obtain additional imaging, notably spinal angiography, is generally based on initial MRI findings. This study retrospectively analyzed the yield of initial MRI in a cohort of patients with angiographically confirmed vascular malformations. MRI obtained at symptom onset was available in 115 patients with either high-flow (29 cases) or low-flow (86 cases) vascular malformations. MRI was classified as "positive" when the report mentioned a vascular malformation or "negative" when considered normal or when another diagnosis was suggested...
February 20, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28220199/-novel-pharmaceutical-treatment-approaches-for-gastric-cancer
#18
F Lordick
This review article delineates novel approaches for the pharmaceutical treatment of gastric cancer. A newly developed molecular classification of gastric cancer based on histology, genetic, epigenetic and proteomic characteristics has evolved. It provides a road map for development of new drugs and combinations as well as for patient stratification in clinical research and it is expected to be introduced into clinical practice in the near future. Anti-HER2 targeted treatment is a validated strategy for treatment of metastatic gastric cancer and is now also being studied in the perioperative setting to increase response rates and ultimately survival in patients undergoing curative surgery; however, the resistance mechanisms of HER2-targeted treatment are poorly understood and optimal patient selection remains challenging...
February 20, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28220196/the-associations-between-serum-25-hydroxyvitamin-d-level-and-the-risk-of-total-fracture-and-hip-fracture
#19
Y Feng, G Cheng, H Wang, B Chen
: In this meta-analysis, we evaluated the association between serum 25-hydroxyvitamin D (25(OH) vitamin D) level and the risk of total fractures and hip fractures. Low serum 25(OH) vitamin D level is associated with an increased risk of total and hip fractures. INTRODUCTION: Data on the association between serum 25(OH) vitamin D level and the risk of fractures are conflicting. This study aimed to provide a summary of prospective cohort or nested case-control studies on the association between serum 25(OH) vitamin D level and the risk of total fractures and hip fractures...
February 20, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28219958/interpretation-and-use-of-evidence-in-state-policymaking-a-qualitative-analysis
#20
Dorie E Apollonio, Lisa A Bero
INTRODUCTION: Researchers advocating for evidence-informed policy have attempted to encourage policymakers to develop a greater understanding of research and researchers to develop a better understanding of the policymaking process. Our aim was to apply findings drawn from studies of the policymaking process, specifically the theory of policy windows, to identify strategies used to integrate evidence into policymaking and points in the policymaking process where evidence was more or less relevant...
February 20, 2017: BMJ Open
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