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https://www.readbyqxmd.com/read/29783221/hygienic-assessment-of-different-forms-of-physical-education-lessons-organization-in-primary-school
#1
Oleksandra S Kondratiuk, Maria M Korshun, Sergii I Garkavyi, Sergii S Garkavyi, Liudmyla A Stasiuk, Olena V Dema, Olga O Sokolovska
OBJECTIVE: Introduction: Different forms of physical education lessons organization, including swimming classes were introduced in education process without studying of its healthsaving effectiveness. The aim of this study was hygienic assessment of different forms of physical education lessons organization in primary school. PATIENTS AND METHODS: Materials and methods: Cross-sectional study was conducted in two schools with different organization of physical education lessons...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783198/toxicity-assessment-of-metal-oxide-nano-pollutants-on-tomato-solanum-lycopersicon-a-study-on-growth-dynamics-and-plant-cell-death
#2
Bilal Ahmed, Mohammad Saghir Khan, Javed Musarrat
The present study for the first time demonstrated the interactions of metal oxide (MO) nano-pollutants (CuO and Al2 O3 -NPs) with tissues and cellular DNA of tomato plants grown in soil sand: silt: clay (667:190:143) and Hoagland-hydroponic system and assessed the hazardous effects of NPs on cell physiology and biochemistry. Results of SEM equipped with EDX revealed attachment of variably shaped CuO-NPs (18 nm) and Al2 O3 -NPs (21 nm) on roots, and internalization followed by translocation in plants by ICP-MS and TEM...
May 18, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29783192/interaction-of-dna-and-mononucleotides-with-theophylline-investigated-using-electrochemical-biosensors-and-biosensing
#3
Katarína Nemčeková, Ján Labuda, Viktor Milata, Jana Blaškovičová, Jozef Sochr
The understanding of DNA-drug interaction mechanism is among the important aspects of biological studies for drug design, discovery and pharmaceutical development processes. Published rather detailed FTIR and UV-visible spectroscopic studies on the interactions of theophylline, theobromine and caffeine with calf thymus DNA have shown effective binding of these methylxanthine derivatives to DNA and RNA involving H-bonds. However, to our knowledge, there is no such investigation using electrochemical approach...
May 3, 2018: Bioelectrochemistry
https://www.readbyqxmd.com/read/29783177/evaluating-long-term-patterns-of-decreasing-groundwater-discharge-through-a-lake-bottom-permeable-reactive-barrier
#4
Timothy D McCobb, Martin A Briggs, Denis R LeBlanc, Frederick D Day-Lewis, Carole D Johnson
Identifying and quantifying groundwater exchange is critical when considering contaminant fate and transport at the groundwater/surface-water interface. In this paper, areally distributed temperature and point seepage measurements are used to efficiently assess spatial and temporal groundwater discharge patterns through a glacial-kettle lakebed area containing a zero-valent iron permeable reactive barrier (PRB). Concern was that the PRB was becoming less permeable with time owing to biogeochemical processes within the PRB...
May 18, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29783151/formation-and-characterization-of-chitosan-protein-particles-with-fractal-whey-protein-aggregates
#5
Khouloud Fekih Ahmed, Adel Aschi, Taco Nicolai
Hybrid protein-polysaccharide particles were formed by complexation of fractal whey protein aggregates and the cationic polysaccharide chitosan. The fractal aggregates were preformed by heating native whey protein isolate at pH 7 and subsequently mixed with chitosan at pH 3 where these proteins and polysaccharides don't interact with each other. Stable dispersions of protein-polysaccharide particles were formed spontaneously when the pH was gradually increased between 4.1 and 6.8, whereas in the absence of chitosan the fractal aggregates precipitated between pH 4...
May 15, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29783146/gas-chromatographic-mass-spectrometric-characterization-of-thebaol-an-opium-constituent-and-its-structural-analogs
#6
Levan Megutnishvili, Nino Todua, Stephen Stein, Anzor Mikaia
A GC-MS method is described for the characterization of thebaol, a component of opium poppy. The method includes preliminary sample derivatization to TMS, TBDMS, TFA, PFP and HFB substituted products. Fragmentation of resulting derivatives is unique under electron ionization, and proceeds via consecutive loss of two radicals that violate the "even-electron rule". Peaks of [M-2CH3 ]+. and [M-C4 H9 -CH3 ]+. ions show maximum intensities in the spectra of trimethyl- and tert-butyldimethylsilyl-thebaols...
May 18, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29783106/prediction-of-the-combined-effects-of-multiple-estrogenic-chemicals-on-mcf-7-human-breast-cancer-cells-and-a-preliminary-molecular-exploration-of-the-estrogenic-proliferative-effects-and-related-gene-expression
#7
Shengwu Yuan, Chao Huang, Xiaoya Ji, Mei Ma, Kaifeng Rao, Zijian Wang
The environmental risks of environmental estrogens (EEs) are often assessed via the same mode of action in the concentration addition (CA) model, neglecting the complex combined mechanisms at the genetic level. In this study, the cell proliferation effects of estrone, 17α-ethinylestradiol, 17β-estradiol, estriol, diethylstilbestrol, estradiol valerate, bisphenol A, 4-tert-octylphenol and 4-nonylphenol were determined individually using the CCK-8 method, and the proliferation effects of a multicomponent mixture of estrogenic chemicals mixed at equipotent concentrations using a fixed-ratio design were studied using estrogen-sensitive MCF-7 cells...
May 18, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29782851/glycosylation-of-cblns-attenuates-their-receptor-binding
#8
Yongqi Rong, Parmil K Bansal, Peng Wei, Hong Guo, Kristen Correia, Jennifer Parris, James I Morgan
Cbln1 is the prototype of a family (Cbln1-Cbln4) of secreted glycoproteins and is essential for normal synapse structure and function in cerebellum by bridging presynaptic Nrxn to postsynaptic Grid2. Here we report the effects of glycosylation on the in vitro receptor binding properties of Cblns. Cbln1, 2 and 4 harbor two N-linked glycosylation sites, one at the N-terminus is in a region implicated in Nrxn binding and the second is in the C1q domain, a region involved in Grid2 binding. Mutation (asparagine to glutamine) of the N-terminal site, increased neurexin binding whereas mutation of the C1q site markedly increased Grid2 binding...
May 18, 2018: Brain Research
https://www.readbyqxmd.com/read/29782822/simultaneous-determination-of-intestinal-permeability-and-potential-drug-interactions-of-complex-mixtures-using-caco-2-cells-and-high-resolution-mass-spectrometry-studies-with-rauwolfia-serpentina-extract
#9
Thomas J Flynn, Sanah N Vohra
Caco-2 cells are a commonly used model for estimating the intestinal bioavailability of single chemical entity pharmaceuticals. Caco-2 cells, when induced with calcitriol, also express other biological functions such as phase I (CYP) and phase II (glucuronosyltransferases) drug metabolizing enzymes which are relevant to drug-supplement interactions. Intestinal bioavailability is an important factor in the overall safety assessment of products consumed orally. Foods, including herbal dietary supplements, are complex substances with multiple chemical components...
May 18, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29782694/metal-organic-framework-hybrid-assisted-formation-of-co-3-o-4-co-fe-oxide-double-shelled-nanoboxes-for-enhanced-oxygen-evolution
#10
Xiao Wang, Le Yu, Bu Yuan Guan, Shuyan Song, Xiong Wen David Lou
Rational design of complex metal-organic framework (MOF) hybrid precursors offers a great opportunity to construct various functional nanostructures. Here, a novel MOF-hybrid-assisted strategy to synthesize Co3 O4 /Co-Fe oxide double-shelled nanoboxes is reported. In the first step, zeolitic imidazolate framework-67 (ZIF-67, a Co-based MOF)/Co-Fe Prussian blue analogue (PBA) yolk-shell nanocubes are formed via a facile anion-exchange reaction between ZIF-67 nanocube precursors and [Fe(CN)6 ]3- ions at room temperature...
May 21, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29782681/highly-efficient-nonfullerene-polymer-solar-cells-enabled-by-a-copper-i-coordination-strategy-employing-an-1-3-4-oxadiazole-containing-wide-bandgap-copolymer-donor
#11
Xiaopeng Xu, Zuojia Li, Zhaozhao Bi, Ting Yu, Wei Ma, Kui Feng, Ying Li, Qiang Peng
A novel wide-bandgap copolymer of PBDT-ODZ based on benzo[1,2-b:4,5-b' ]dithiophene (BDT) and 1,3,4-oxadiazole (ODZ) blocks is developed for efficient nonfullerene polymer solar cells (NF-PSCs). PBDT-ODZ exhibits a wide bandgap of 2.12 eV and a low-lying highest occupied molecular orbital (HOMO) level of -5.68 eV, which could match well with the low-bandgap acceptor of 3,9-bis(2-methylene-(3-(1,1-dicyanomethylene)-indanone)-5,5,11,11-tetrakis(4-hexylthienyl)-dithieno[2,3-d:2',3'-d']-s-indaceno[1,2-b:5,6-b']-dithiophene (ITIC-Th), inducing a good complementary absorption from 300 to 800 nm and a minimal HOMO level offset (0...
May 21, 2018: Advanced Materials
https://www.readbyqxmd.com/read/29782530/histone-methylation-changes-are-required-for-life-cycle-progression-in-the-human-parasite-schistosoma-mansoni
#12
David Roquis, Aaron Taudt, Kathrin K Geyer, Gilda Padalino, Karl F Hoffmann, Nancy Holroyd, Matt Berriman, Benoît Aliaga, Cristian Chaparro, Christoph Grunau, Ronaldo de Carvalho Augusto
Epigenetic mechanisms and chromatin structure play an important role in development. Their impact is therefore expected to be strong in parasites with complex life cycles and multiple, strikingly different, developmental stages, i.e. developmental plasticity. Some studies have already described how the chromatin structure, through histone modifications, varies from a developmental stage to another in a few unicellular parasites. However, this, to our knowledge, has never been done before in multicellular metazoan parasites...
May 21, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29782498/endoplasmic-reticulum-plasma-membrane-contact-sites-integrate-sterol-and-phospholipid-regulation
#13
Evan Quon, Yves Y Sere, Neha Chauhan, Jesper Johansen, David P Sullivan, Jeremy S Dittman, William J Rice, Robin B Chan, Gilbert di Paolo, Christopher T Beh, Anant K Menon
Tether proteins attach the endoplasmic reticulum (ER) to other cellular membranes, thereby creating contact sites that are proposed to form platforms for regulating lipid homeostasis and facilitating non-vesicular lipid exchange. Sterols are synthesized in the ER and transported by non-vesicular mechanisms to the plasma membrane (PM), where they represent almost half of all PM lipids and contribute critically to the barrier function of the PM. To determine whether contact sites are important for both sterol exchange between the ER and PM and intermembrane regulation of lipid metabolism, we generated Δ-super-tether (Δ-s-tether) yeast cells that lack six previously identified tethering proteins (yeast extended synatotagmin [E-Syt], vesicle-associated membrane protein [VAMP]-associated protein [VAP], and TMEM16-anoctamin homologues) as well as the presumptive tether Ice2...
May 21, 2018: PLoS Biology
https://www.readbyqxmd.com/read/29782489/systematic-identification-of-factors-mediating-accelerated-mrna-degradation-in-response-to-changes-in-environmental-nitrogen
#14
Darach Miller, Nathan Brandt, David Gresham
Cellular responses to changing environments frequently involve rapid reprogramming of the transcriptome. Regulated changes in mRNA degradation rates can accelerate reprogramming by clearing or stabilizing extant transcripts. Here, we measured mRNA stability using 4-thiouracil labeling in the budding yeast Saccharomyces cerevisiae during a nitrogen upshift and found that 78 mRNAs are subject to destabilization. These transcripts include Nitrogen Catabolite Repression (NCR) and carbon metabolism mRNAs, suggesting that mRNA destabilization is a mechanism for targeted reprogramming of the transcriptome...
May 21, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29782427/clinical-profile-of-levamisole-adulterated-cocaine-induced-vasculitis-vasculopathy-a-30-case-series
#15
Carlos Horacio Muñoz-Vahos, Sebastián Herrera-Uribe, Álvaro Arbeláez-Cortés, Daniel Jaramillo-Arroyave, Luis Alonso González-Naranjo, Gloria Vásquez-Duque, Mauricio Restrepo-Escobar, Luis Alfonso Correa-Londoño, Luis Fernando Arias-Restrepo, Adriana Lucía Vanegas-García
OBJECTIVES: The aims of this study were to describe clinical and laboratory manifestations of patients with levamisole-adulterated cocaine-induced vasculitis/vasculopathy and to propose a skin classification according to the distribution and severity of lesions. METHODS: We report the characteristics of 30 patients admitted with levamisole-adulterated cocaine-induced vasculitis/vasculopathy in 4 high-complexity institutions in Colombia, from December 2010 to May 2017...
May 19, 2018: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/29782250/-effect-of-right-ventricular-myocardial-contractility-on-the-response-to-cardiac-resynchronization-therapy
#16
D I Lebedev, S V Popov, A I Mishkina, M V Lebedeva
AIM: To determine the effect of right ventricular myocardial contractility on the response to cardiac resynchronization therapy (CRT). MATERIALS AND METHODS: The study included 80 patients (49 men, mean age 54±10.5) diagnosed with dilated cardiomyopathy, complete left bundle branch block, and the QRS complex width 146 to 240 ms (183±32 ms). Heart failure was NYHA FC III, ejection fraction (EF) - 30.1±3.8 %, 6‑min walk test - 290.5±64.3 m, and end-diastolic volume (EDV) - 220...
2018: Kardiologiia
https://www.readbyqxmd.com/read/29782155/a-narrow-gap-semiconducting-germanium-allotrope-from-the-oxidation-of-a-layered-zintl-phase-in-ionic-liquids
#17
Zhongjia Tang, Alexander P Litvinchuk, Melissa Gooch, Arnold M Guloy
A metastable germanium allotrope, Ge(oP32), was synthe-sized as polycrystalline powders and single crystals from the mild-oxidation/delithiation of Li7Ge12 in ionic liquids. Its crystal structure, from single crystal X-ray diffraction (P bcm, a = 8.1527(4) Å, b = 11.7572(5) Å, c = 7.7617(4) Å), features a complex covalent network of 4-bonded Ge, resulting from a well-ordered topotactic oxidative condensation of [Ge12 ]7- layers. It is a diamagnetic semiconductor (Eg = 0.33 eV), and transforms exothermically and irreversibly to α-Ge at 363 °C...
May 21, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29781996/replication-of-the-ordered-nonredundant-library-of-pseudomonas-aeruginosa-strain-pa14-transposon-insertion-mutants
#18
Eliana Drenkard, Rhianna M Hibbler, D Alina Gutu, Alexander D Eaton, Amy L Silverio, Frederick M Ausubel, Bryan P Hurley, Lael M Yonker
Pseudomonas aeruginosa is a phenotypically and genotypically diverse and adaptable Gram-negative bacterium ubiquitous in human environments. P. aeruginosa is able to form biofilms, develop antibiotic resistance, produce virulence factors, and rapidly evolve in the course of a chronic infection. Thus P. aeruginosa can cause both acute and chronic, difficult to treat infections, resulting in significant morbidity in certain patient populations. P. aeruginosa strain PA14 is a human clinical isolate with a conserved genome structure that infects a variety of mammalian and nonvertebrate hosts making PA14 an attractive strain for studying this pathogen...
May 4, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29781624/helium-ion-microscopy-as-a-high-resolution-probe-for-complex-quantum-heterostructures-in-core-shell-nanowires
#19
Christian Pöpsel, Jonathan Becker, Nari Jeon, Markus Döblinger, Thomas Stettner, Yeanitza Trujillo Gottschalk, Bernhard Loitsch, Sonja Matich, Marcus Altzschner, Alexander W Holleitner, Jonathan Finley, Lincoln J Lauhon, Gregor Koblmueller
Core-shell semiconductor nanowires (NW) with internal quantum heterostructures are among the most complex nanostructured materials to be explored for assessing the ultimate capabilities of diverse ultrahigh-resolution imaging techniques. To probe the structure and composition of these materials in their native environment with minimal damage and sample preparation calls for high-resolution electron or ion microscopy methods, which have not yet been tested on such classes of ultra-small quantum nanostructures...
May 21, 2018: Nano Letters
https://www.readbyqxmd.com/read/29781614/two-step-sequence-of-cycloadditions-gives-structurally-complex-tetracyclic-1-2-3-4-tetrahydrocinnoline-products
#20
Ram Dhakal, Monika Ivancic, Matthias Brewer
Intramolecular [4 + 2]-cycloaddition of heteroallene salts gives polycyclic tetrahydrocinnoline structures that contain an N-aminoiminium motif. Deprotonation with mild base gives the corresponding azomethine imines, which readily participate in 1,3-dipolar cycloaddition reactions. The structurally complex tetracyclic 1,2,3,4-tetrahydrocinnoline products typically form as a mixture of two separable diastereomers. The major diastereomer is generally formed by reaction of the dipolarophile with the convex face of the dipole...
May 21, 2018: Journal of Organic Chemistry
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