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https://www.readbyqxmd.com/read/28536198/understanding-the-essential-proton-pumping-kinetic-gates-and-decoupling-mutations-in-cytochrome-c-oxidase
#1
Ruibin Liang, Jessica M J Swanson, Mårten Wikström, Gregory A Voth
Cytochrome c oxidase (CcO) catalyzes the reduction of oxygen to water and uses the released free energy to pump protons against the transmembrane proton gradient. To better understand the proton-pumping mechanism of the wild-type (WT) CcO, much attention has been given to the mutation of amino acid residues along the proton translocating D-channel that impair, and sometimes decouple, proton pumping from the chemical catalysis. Although their influence has been clearly demonstrated experimentally, the underlying molecular mechanisms of these mutants remain unknown...
May 23, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28531864/determination-of-volumetric-gas-liquid-mass-transfer-coefficient-of-carbon-monoxide-in-a-batch-cultivation-system-using-kinetic-simulations
#2
Nulee Jang, Muhammad Yasin, Shinyoung Park, Robert W Lovitt, In Seop Chang
A mathematical model of microbial kinetics was introduced to predict the overall volumetric gas-liquid mass transfer coefficient (kLa) of carbon monoxide (CO) in a batch cultivation system. The cell concentration (X), acetate concentration (Cace), headspace gas (Nco and [Formula: see text] ), dissolved CO concentration in the fermentation medium (Cco), and mass transfer rate (R) were simulated using a variety of kLa values. The simulated results showed excellent agreement with the experimental data for a kLa of 13/hr...
May 6, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28493664/structure-and-spectroscopy-of-alkene-cleaving-dioxygenases-containing-an-atypically-coordinated-non-heme-iron-center
#3
Xuewu Sui, Andrew C Weitz, Erik R Farquhar, Mohsen Badiee, Surajit Banerjee, Johannes von Lintig, Gregory Tochtrop, Krzysztof Palczewski, Michael P Hendrich, Philip D Kiser
Carotenoid cleavage oxygenases (CCOs) are non-heme iron enzymes that catalyze scission of alkene groups in carotenoids and stilbenoids to form biologically important products. CCOs possess a rare 4-His iron center whose resting-state structure and interaction with substrates are incompletely understood. Here, we address this knowledge gap through a comprehensive structural and spectroscopic study of three phyletically diverse CCOs. The crystal structure of a fungal stilbenoid-cleaving CCO, CAO1, reveals strong similarity between its iron center and those of carotenoid-cleaving CCOs, but with a markedly different substrate-binding cleft...
May 11, 2017: Biochemistry
https://www.readbyqxmd.com/read/28490636/the-cox1-carboxyl-terminal-domain-is-a-central-regulator-of-cytochrome-c-oxidase-biogenesis-in-yeast-mitochondria
#4
Rodolfo García-Villegas, Yolanda Camacho-Villasana, Miguel Ángel Shingú-Vázquez, Alfredo Cabrera-Orefice, Salvador Uribe-Carvajal, Thomas D Fox, Xochitl Pérez-Martínez
Cytochrome c oxidase (CcO) is the last electron acceptor in the respiratory chain. The CcO core is formed by mitochondrial DNA-encoded Cox1, Cox2, and Cox3 subunits. Cox1 synthesis is highly regulated; for example, if CcO assembly is blocked, Cox1 synthesis decreases. Mss51 activates translation of COX1 mRNA and interacts with Cox1 protein in high-molecular-weight complexes (COA complexes) to form the Cox1 intermediary assembly module. Thus, Mss51 coordinates both Cox1 synthesis and assembly. We previously reported that the last 15 residues of the Cox1 C-terminus regulate Cox1 synthesis by modulating an interaction of Mss51 with Cox14, another component of the COA complexes...
May 10, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28474287/evaluation-of-the-case-crossover-cco-study-design-for-adverse-drug-event-detection
#5
Zachary Burningham, Tao He, Chia-Chen Teng, Xi Zhou, Jonathan Nebeker, Brian C Sauer
INTRODUCTION: The case-crossover (CCO) design was originally intended to study exposures characterized as intermittent with acute effects. The performance of the CCO design is not well characterized under alternative exposure and outcome relationships. OBJECTIVE: The purpose of this study was to evaluate the ability of the CCO to identify simulated treatment effects under different drug exposures and outcomes relationships while varying the duration of the 1:1 matched risk and control windows...
May 4, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28455961/repositioning-chlorpromazine-for-treating-chemoresistant-glioma-through-the-inhibition-of-cytochrome-c-oxidase-bearing-the-cox4-1-regulatory-subunit
#6
Claudia R Oliva, Wei Zhang, Cathy Langford, Mark J Suto, Corinne E Griguer
Patients with glioblastoma have one of the lowest overall survival rates among patients with cancer. Standard of care for patients with glioblastoma includes temozolomide and radiation therapy, yet 30% of patients do not respond to these treatments and nearly all glioblastoma tumors become resistant. Chlorpromazine is a United States Food and Drug Administration-approved phenothiazine widely used as a psychotropic in clinical practice. Recently, experimental evidence revealed the anti-proliferative activity of chlorpromazine against colon and brain tumors...
April 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/28451469/comparative-effectiveness-of-clostridial-collagenase-ointment-to-medicinal-honey-for-treatment-of-pressure-ulcers
#7
Adrienne M Gilligan, Curtis R Waycaster, Richard Bizier, Bong-Chul Chu, Marissa J Carter, Caroline E Fife
Objective: Compare enzymatic debridement using clostridial collagenase ointment (CCO) with autolytic debridement using medicinal honey in the hospital outpatient setting for treating pressure ulcers (PUs). Approach: Retrospective deidentified electronic health records from 2007-2013 were extracted from the U.S. Wound Registry. Propensity score matching followed by multivariable analyses was used to adjust for selection bias and assess treatment effects comparing CCO-treated versus honey-treated PUs. Key outcomes included 100% granulation and epithelialization at 1 year...
April 1, 2017: Advances in Wound Care
https://www.readbyqxmd.com/read/28450002/energy-status-regulates-disease-development-and-respiratory-metabolism-of-lasiodiplodia-theobromae-pat-griff-maubl-infected-longan-fruit
#8
Shen Zhang, Hetong Lin, Yifen Lin, Yixiong Lin, Yen-Con Hung, Yihui Chen, Hui Wang, John Shi
Lasiodiplodia theobromae (Pat.) Griff. & Maubl. is a major pathogen causing decay of harvested longan fruit. The roles of energy status regulated by 2,4-dinitrophenol (DNP) and adenosine triphosphate (ATP) in disease development regarding respiratory metabolism of L. theobromae-inoculated "Fuyan" longan fruit were studied. Compared with L. theobromae-inoculated longans, DNP treatment could promote the index of fruit disease, accelerate the decrease in energy charge, increase respiration rate and the activities of respiratory terminal oxidases like CCO, AAO and PPO, elevate contents of NAD and NADH, but decrease NAD kinase activity, as well as contents of NADP and NADPH; however, exogenous ATP supply acted contrarily...
September 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/28442264/mitochondrial-lon-protease-dependent-degradation-of-cytochrome-c-oxidase-subunits-under-hypoxia-and-myocardial-ischemia
#9
Naresh B V Sepuri, Rajesh Angireddy, Satish Srinivasan, Manti Guha, Joseph Spear, Bin Lu, Hindupur K Anandatheerthavarada, Carolyn K Suzuki, Narayan G Avadhani
The mitochondrial ATP dependent matrix protease, Lon, is involved in the maintenance of mitochondrial DNA nucleoids and degradation of abnormal or misfolded proteins. The Lon protease regulates mitochondrial Tfam (mitochondrial transcription factor A) level and thus modulates mitochondrial DNA (mtDNA) content. We have previously shown that hypoxic stress induces the PKA-dependent phosphorylation of cytochrome c oxidase (CcO) subunits I, IVi1, and Vb and a time-dependent reduction of these subunits in RAW 264...
April 23, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28407595/proteo-lipobeads-to-encapsulate-cytochrome-c-oxidase-from-paracoccus-denitrificans
#10
Andreas F Geiss, Christina Bliem, Pinar Frank, Ciril Reiner-Rozman, Justin Kewney, Michael Boersch, Renate L C Naumann
Proteo-lipobeads (PLBs) are investigated as cell-free model systems to encapsulate membrane proteins such as ion channels and transporters. PLBs are based on nickel nitrile tri-acetic acid (Ni-NTA)-functionalized agarose beads, onto which membrane proteins (MP) are bound via histidine(his)-tag. Composite beads thus obtained (subsequently called proteobeads) are dialyzed in the presence of lipid micelles to form PLBs. As an example we employed cytochrome c oxidase from P. denitrificans with a his-tag fused to the C-terminus of subunitI...
April 5, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28390808/morphological-characteristics-of-external-auditory-canal-in-congenital-aural-stenosis-patients
#11
Dongming Yin, Chenlong Li, Keguang Chen, Juan Hong, Jieying Li, Lin Yang, Tianyu Zhang, Peidong Dai
Objective To investigate characteristics of congenital aural stenosis (CAS) patients' external auditory canal (EAC) (position, length, orientation, etc.) and compare them with normal EAC. METHODS: CT images of normal people and CAS patient were utilized. We obtained coordinates of EAC landmarks. Then the Matlab program could calculate some anatomic parameters about EAC, including distances from central point of tympanic annulus (CA), central point of osseous EAC opening (CO), central point of cartilaginous EAC inside opening (CCi), central point of cartilaginous EAC outside opening (CCo) to the Frankfurt horizontal plane (Pfrkt), the median sagittal plane (Psag), the coronal plane (Pcor); orientations of EAC bendings; straight and arc lengths of EAC...
April 1, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28382074/inhibiting-cytochrome-c-oxidase-leads-to-alleviated-ischemia-reperfusion-injury
#12
Zhaoyun Yang, Zhongxin Duan, Tian Yu, Junmei Xu, Lei Liu
BACKGROUND AND OBJECTIVES: The overall purpose of this study was to investigate the role of cytochrome C oxidase (CcO) in preventing ischemia reperfusion-induced cardiac injury through gaseous signaling molecule pathways. MATERIALS AND METHODS: We used CcO inhibitor, potassium cyanide (KCN) to mimic the pre-treatment of gaseous signaling molecules in a global ischemia/reperfusion (IR) injury model in rats. Intracellular reactive oxygen species (ROS) was determined by measuring mitochondrial H2O2 and mitochondrial complex activity...
March 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28357365/cox1-mutation-abrogates-need-for-cox23-in-cytochrome-c-oxidase-biogenesis
#13
Richard Dela Cruz, Mi-Young Jeong, Dennis R Winge
Cox23 is a known conserved assembly factor for cytochrome c oxidase, although its role in cytochrome c oxidase (CcO) biogenesis remains unresolved. To gain additional insights into its role, we isolated spontaneous suppressors of the respiratory growth defect in cox23∆ yeast cells. We recovered independent colonies that propagated on glycerol/lactate medium for cox23∆ cells at 37°C. We mapped these mutations to the mitochondrial genome and specifically to COX1 yielding an I(101)F substitution. The I(101)F Cox1 allele is a gain-of-function mutation enabling yeast to respire in the absence of Cox23...
June 30, 2016: Microbial Cell
https://www.readbyqxmd.com/read/28274170/protective-effects-of-cassia-tora-leaves-in-experimental-cataract-by-modulating-intracellular-communication-membrane-co-transporters-energy-metabolism-and-the-ubiquitin-proteasome-pathway
#14
V Sreelakshmi, Annie Abraham
CONTEXT: Cataract is the clouding of eye lens which causes impairment in vision and accounts for the leading factor of global blindness. Functional food-based prevention of cataract finds application in vision research because of its availability and easy access to all classes of the society. Cassia tora Linn. (Caesalpinaceae) is an edible plant mentioned in the traditional systems of medicine for whole body health, especially to the eyes. OBJECTIVE: The present study evaluates the potential of ethyl acetate fraction of Cassia tora leaves (ECT) on experimental cataract...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28273124/blockade-of-cyclophilin-d-rescues-dexamethasone-induced-oxidative-stress-in-gingival-tissue
#15
Yuting He, Ling Zhang, Zhuoli Zhu, Anqi Xiao, Haiyang Yu, Xueqi Gan
Glucocorticoids (GCs) are frequently used for the suppression of inflammation in chronic inflammatory diseases. Excessive GCs usage is greatly associated with several side effects, including gingival ulceration, the downward migration of the epithelium, attachment loss and disruption of transeptal fibers. The mechanisms underlying GCs-induced impairments in gingival tissue remains poorly understood. Mitochondrial dysfunction is associated with various oral diseases, such as chronic periodontitis, age-related alveolar bone loss and hydrogen peroxide-induced cell injury in gingival...
2017: PloS One
https://www.readbyqxmd.com/read/28267678/enzymatic-debridement-of-chronic-nonischemic-diabetic-foot-ulcers-results-of-a-randomized-controlled-trial
#16
Juan Carlos Jimenez, Patrick S Agnew, Perry Mayer, John R Clements, Joseph M Caporusso, Darrell L Lange, Jaime E Dickerson, Herbert B Slade
OBJECTIVE: The aim of this randomized, controlled multicenter trial was to evaluate the clinical outcomes associated with the use of clostridial collagenase ointment (CCO) for up to 12 weeks in 215 patients with type 1 or type 2 diabetes mellitus and a neuropathic, nonischemic diabetic foot ulcer (DFU). MATERIALS AND METHODS: Patients were randomized into either a group receiving CCO applied once daily at a thickness of ~2 mm or a group receiving standard care (SC) consisting of a daily application of a hydrogel as needed to maintain a moist ulcer environment...
February 27, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28262300/invasive-mediastinal-staging-guideline%C3%A2-concordance
#17
Anna Bendzsak, Thomas K Waddell, Kazuhiro Yasufuku, Shaf Keshavjee, Marc de Perrot, Marcelo Cypel, Andrew F Pierre, Gail E Darling
BACKGROUND: Despite guidelines for preoperative invasive mediastinal staging (IMS) for non-small cell lung cancer (NSCLC), concordance with guidelines and whether the use of these guidelines results in expected frequency of lymph node metastases has not been evaluated. Our objectives were to determine guideline concordance, reasons for nonconcordance, and, in patients who did not receive IMS, to determine the use of operative nodal sampling and final pathologic staging. METHODS: Patients who had a resection for NSCLC between 2010 and 2012 were identified from the Institutional Cancer Registry...
June 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28242320/a-positive-feedback-loop-between-nitric-oxide-and-amyloid-%C3%AE-1-42-accelerates-mitochondrial-damage-in-human-lens-epithelial-cells
#18
Noriaki Nagai, Yoshimasa Ito, Teppei Shibata, Eri Kubo, Hiroshi Sasaki
We have reported that excessive nitric oxide (NO), like other reactive oxygen species (ROS), causes a decrease in cytochrome c oxidase (CCO) activity and ATP levels (mitochondrial damage) resulting in lens opacity. In addition, previous reports have shown that oxidative stress caused by ROS enhances amyloid β (Aβ) production in mammalian lenses, and that Aβ1-42 stimulates inducible nitric oxide synthase (iNOS) promoter activity. Based on these reports, we investigated the relationship between NO and Aβ1-42 production in human lens epithelial (HLE) cells...
April 15, 2017: Toxicology
https://www.readbyqxmd.com/read/28240158/biodiesel-production-from-citrillus-colocynthis-oil-using-based-catalytic-reaction-and-characterization-studies
#19
Imededdine A Nehdi, Hassen M Sbihi, Lahssen El Blidi, Umer Rashid, Saud I Al-Resayes
In this investigation, an enzyme catalyzed process was optimized to prepare methyl esters from crude Citrullus colocynthis oil (CCO). Novozym 435 was used to synthesize biodiesel by transesterification of CCO with methanol. Use of tert-butanol as a reaction medium eliminated negative effects caused by excess methanol and formation of glycerol byproduct. Several variables affecting the Citrullus colocynthis methyl ester (CCME) yield including lipase quantity, water content, methanol/oil mole ratio, reaction temperature, reaction medium composition, and reaction time were optimized...
February 23, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28199277/funding-accountable-care-in-oregon-financial-models-in-two-coordinated-care-organizations
#20
Lauren Broffman, Kristin Brown, Bruce K Bayley, Lucy Savitz, Jill Rissi
Oregon's coordinated care organizations (CCOs) are an integral part of a massive statewide reform that brings accountable care to Medicaid. CCOs are regional collaboratives among health plans, providers, county public health, and communitybased organizations that administer a single global budget covering physical, mental, and dental healthcare for low-income Oregonians. CCOs have been given freedom within the global budget to implement reforms that might capture efficiencies in cost and quality. For this study-fielded between 2012 and 2015-we traced the path of the global budget through the interior structures of two of Oregon's most promising CCOs...
July 2016: Journal of Healthcare Management / American College of Healthcare Executives
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