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https://www.readbyqxmd.com/read/27905692/remote-pre-procedural-ischemic-stroke-was-the-strongest-risk-for-stroke-and-death-associated-with-carotid-stenting-a-single-center-experience
#1
Mária Rašiová, Ľubomír Špak, Ľudmila Farkašová, Štefan Pataky, Martin Koščo, Marek Hudák, Matej Moščovič, Norbert Leško
BACKGROUND: The goal of carotid artery stenting (CAS) is to decrease the stroke risk in patients with carotid stenosis. This procedure carries an immediate risk of stroke and death and many patients do not benefit from it, especially asymptomatic patients. Patient selection for carotid procedure who benefit from procedure and who is the procedure hazardous for is important. Remote ischemic stroke is known risk factor for stroke reccurence during surgery. The aim of our study was to determine the periprocedural complication risk (within 30 days after CAS) associated with carotid stenting (stroke, death) between patients with remote pre- procedural ischemic stroke and without it; to analyse periprocedural risk in other specific patient subgroups treated with CAS and to determine the impact of observed variables on all- cause mortality during long-term follow-up...
December 1, 2016: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/27888650/closure-of-the-cervical-os-in-patients-after-fertility-preserving-treatment-for-early-cervical-cancer-results-of-a-prospective-observational-study
#2
Mandy Mangler, Malgorzata Lanowska, Anne Bartens, Aaron Schindler, Jens-Uwe Blohmer, Dorothee Speiser
INTRODUCTION: Up to 50% of the infants delivered after radical vaginal trachelectomy (RVT) are born prematurely. An effective strategy to reduce this number could be the closure of the cervical os (CCO). PATIENTS AND METHODS: Fifteen pregnant patients who had a RVT due to early cervical cancer were included in this prospective case control study. All patients were scheduled for CCO early in the second trimester. CCO was performed in 12 patients. Their data were compared to data from 125 pregnancies after a RVT without CCO...
November 26, 2016: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/27861614/photobiomodulation-with-pulsed-and-continuous-wave-near-infrared-laser-810-nm-al-ga-as-augments-dermal-wound-healing-in-immunosuppressed-rats
#3
Gaurav K Keshri, Asheesh Gupta, Anju Yadav, Sanjeev K Sharma, Shashi Bala Singh
Chronic non-healing cutaneous wounds are often vulnerable in one or more repair phases that prevent normal healing and pose challenges to the use of conventional wound care modalities. In immunosuppressed subject, the sequential stages of healing get hampered, which may be the consequences of dysregulated or stagnant wound inflammation. Photobiomodulation (PBM) or low-level laser (light) therapy (LLLT) emerges as a promising drug-free, non-invasive biophysical approach for promoting wound healing, reduction of inflammation, pain and restoration of functions...
2016: PloS One
https://www.readbyqxmd.com/read/27856718/central-and-peripheral-responses-to-static-and-dynamic-stretch-of-skeletal-muscle-mechano-and-metabo-reflex-implications
#4
Massimo Venturelli, Emiliano Cé, Eloisa Limonta, Angela V Bisconti, Michela Devoto, Susanna Rampichini, Fabio Esposito
Passive static stretching (SS), circulatory cuff occlusion (CCO), and the combination of both (SS+CCO) have been used to investigate the mechano- and metabo-reflex, respectively. However, the effects of dynamic stretching (DS) alone or in combination with CCO (DS+CCO) on the same reflexes have never been explored. The aim of the study was to compare central and peripheral hemodynamic responses to DS, SS, DS+CCO, and SS+CCO. In ten participants, femoral blood flow (FBF), heart rate (HR), cardiac output (CO), and mean arterial pressure (MAP) were assessed during DS and SS of the quadriceps muscle with and without CCO...
November 17, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27837190/hyperoxia-results-in-increased-aerobic-metabolism-following-acute-brain-injury
#5
Arnab Ghosh, David Highton, Christina Kolyva, Ilias Tachtsidis, Clare E Elwell, Martin Smith
Acute brain injury is associated with depressed aerobic metabolism. Below a critical mitochondrial pO2 cytochrome c oxidase, the terminal electron acceptor in the mitochondrial respiratory chain, fails to sustain oxidative phosphorylation. After acute brain injury, this ischaemic threshold might be shifted into apparently normal levels of tissue oxygenation. We investigated the oxygen dependency of aerobic metabolism in 16 acutely brain-injured patients using a 120-min normobaric hyperoxia challenge in the acute phase (24-72 h) post-injury and multimodal neuromonitoring, including transcranial Doppler ultrasound-measured cerebral blood flow velocity, cerebral microdialysis-derived lactate-pyruvate ratio (LPR), brain tissue pO2 (pbrO2), and tissue oxygenation index and cytochrome c oxidase oxidation state (oxCCO) measured using broadband spectroscopy...
November 11, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27830025/sevoflurane-postconditioning-improves-myocardial-mitochondrial-respiratory-function-and-reduces-myocardial-ischemia-reperfusion-injury-by-up-regulating-hif-1
#6
Long Yang, Peng Xie, Jianjiang Wu, Jin Yu, Tian Yu, Haiying Wang, Jiang Wang, Zhengyuan Xia, Hong Zheng
BACKGROUND: Sevoflurane postconditioning (SPostC) can exert myocardial protective effects similar to ischemic preconditioning. However, the exact myocardial protection mechanism by SPostC is unclear. Studies indicate that hypoxia-inducible factor-1 (HIF-1) maintains cellular respiration homeostasis by regulating mitochondrial respiratory chain enzyme activity under hypoxic conditions. This study investigated whether SPostC could regulate the expression of myocardial HIF-1α and to improve mitochondrial respiratory function, thereby relieving myocardial ischemia-reperfusion injury in rats...
2016: American Journal of Translational Research
https://www.readbyqxmd.com/read/27829282/dan-sargent-cco-associate-editor-and-mayo-biostatistician-and-clinical-trialist-dies-unexpectedly-at-46
#7
Helen Seliman
No abstract text is available yet for this article.
October 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/27810193/redox-induced-protonation-of-heme-propionates-in-cytochrome-c-oxidase-insights-from-surface-enhanced-resonance-raman-spectroscopy-and-qm-mm-calculations
#8
Murat Sezer, Anna-Lena Woelke, Ernst Walter Knapp, Ramona Schlesinger, Maria Andrea Mroginski, Inez M Weidinger
Understanding the coupling between heme reduction and proton translocation in cytochrome c oxidase (CcO) is still an open problem. The propionic acids of heme a3 have been proposed to act as a proton loading site (PLS) in the proton pumping pathway, yet this proposal could not be verified by experimental data so far. We have set up an experiment where the redox states of the two hemes in CcO can be controlled via external electrical potential. Surface enhanced resonance Raman (SERR) spectroscopy was applied to simultaneously monitor the redox state of the hemes and the protonation state of the heme propionates...
October 31, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27808364/genome-wide-identification-phylogenetic-relationships-and-expression-analysis-of-the-carotenoid-cleavage-oxygenase-gene-family-in-pepper
#9
X H Zhang, H Q Liu, Q W Guo, C F Zheng, C S Li, X M Xiang, D F Zhao, J Liu, J Luo, D K Zhao, J Q Zheng, H J Wan
Carotenoid cleavage oxygenases (CCOs) are a family of dioxygenases, which specifically catalyze the cleavage of conjugated double bonds in carotenoids and apocarotenoids in plants. In this study, genome-wide analysis of CCO genes in pepper plants was performed using bioinformatic methods. At least 11 members of the CCO gene family were identified in the pepper genome. Phylogenetic analysis showed that pepper and tomato CCO genes could be divided into two groups (CCDs and NCEDs). The CCD group included five sub-groups (CCD1, CCD4, CCD7, CCD8, and CCD-like)...
October 5, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27793615/seasonal-variation-of-metabolism-in-lizard-phrynocephalus-vlangalii-at-high-altitude
#10
Shiwei Liang, Weixin Li, Yang Zhang, Xiaolong Tang, Jianzheng He, Yucheng Bai, Dongqin Li, Yan Wang, Qiang Chen
Seasonal acclimatization is important for animals to live optimally in the varying environment. Phrynocephalus vlangalii, a species of lizard endemic in China, distributes on Qinghai-Tibet Plateau ranging from 2000 to 4600m above sea level. To dissect how this lizard mediate metabolism to adapt various season, the preferred body temperature (Tb), standard metabolic rate (SMR), mitochondrial respiration rates and activities of four metabolic enzymes in this species were tested in different seasons (spring, summer, and autumn)...
October 26, 2016: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/27774840/cost-effectiveness-of-adding-clostridial-collagenase-ointment-to-selective-debridement-in-individuals-with-stage-iv-pressure-ulcers
#11
Marissa J Carter, Adrienne M Gilligan, Curtis R Waycaster, Kathleen Schaum, Caroline E Fife
OBJECTIVE: The purpose of this study was to determine the cost-effectiveness (from a payer's perspective) of adding clostridial collagenase ointment (CCO) to selective debridement compared with selective debridement alone (non-CCO) in the treatment of stage IV pressure ulcers among patients identified from the US Wound Registry. METHODS: A 3-state Markov model was developed to determine costs and outcomes between the CCO and non-CCO groups over a 2-year time horizon...
October 22, 2016: Journal of Medical Economics
https://www.readbyqxmd.com/read/27768969/taurine-promotes-cognitive-function-in-prenatally-stressed-juvenile-rats-via-activating-the-akt-creb-pgc1%C3%AE-pathway
#12
Ning Jia, Qinru Sun, Qian Su, Shaokang Dang, Guomin Chen
Substantial evidence has shown that the oxidative damage to hippocampal neurons is associated with the cognitive impairment induced by adverse stimuli during gestation named prenatal stress (PS). Taurine, a conditionally essential amino acid, possesses multiple roles in the brain as a neuromodulator or antioxidant. In this study, to explore the roles of taurine in PS-induced learning and memory impairment, prenatal restraint stress was set up and Morris water maze (MWM) was employed for testing the cognitive function in the one-month-old rat offspring...
October 13, 2016: Redox Biology
https://www.readbyqxmd.com/read/27759174/estimated-combined-cardiac-output-and-laser-therapy-for-twin-twin-transfusion-syndrome
#13
Shiraz A Maskatia, Rodrigo Ruano, Alireza A Shamshirsaz, Pouya Javadian, Joshua A Kailin, Michael A Belfort, Carolyn A Altman, Nancy A Ayres
INTRODUCTION: Twin-twin transfusion syndrome (TTTS) is the major cause for fetal demise in monochorionic diamniotic pregnancies. Estimated combined cardiac output (CCO) has not been studied in this setting. The primary aims of this study were to compare CCO in twin donor and recipient fetuses and assess differences in CCO before and after laser coagulation therapy. A secondary aim was to evaluate the relationship of CCO with perinatal mortality, defined as intrauterine or neonatal mortality (≤30 days of age) in fetuses that underwent laser coagulation therapy...
October 2016: Echocardiography
https://www.readbyqxmd.com/read/27752633/chest-compression-quality-exercise-intensity-and-energy-expenditure-during-cardiopulmonary-resuscitation-using-compression-to-ventilation-ratios-of-15-1-or-30-2-or-chest-compression-only-a-randomized-crossover-manikin-study
#14
Se-Jung Kwak, Young-Min Kim, Hee Jin Baek, Se Hong Kim, Hyeon Woo Yim
OBJECTIVE: Our aim was to compare the compression quality, exercise intensity, and energy expenditure in 5-minute single-rescuer cardiopulmonary resuscitation (CPR) using 15:1 or 30:2 compression-to-ventilation (C:V) ratios or chest compression only (CCO). METHODS: This was a randomized, crossover manikin study. Medical students were randomized to perform either type of CPR and do the others with intervals of at least 1 day. We measured compression quality, ratings of perceived exertion (RPE) score, heart rate, maximal oxygen uptake, and energy expenditure during CPR...
September 2016: Clinical and Experimental Emergency Medicine
https://www.readbyqxmd.com/read/27679486/identification-of-small-molecule-inhibitors-of-human-cytochrome-c-oxidase-that-target-chemoresistant-glioma-cells
#15
Claudia R Oliva, Tahireh Markert, Larry J Ross, E Lucile White, Lynn Rasmussen, Wei Zhang, Maaike Everts, Douglas R Moellering, Shannon M Bailey, Mark J Suto, Corinne E Griguer
The enzyme cytochrome c oxidase (CcO) or complex IV (EC 1.9.3.1) is a large transmembrane protein complex that serves as the last enzyme in the respiratory electron transport chain of eukaryotic mitochondria. CcO promotes the switch from glycolytic to oxidative phosphorylation (OXPHOS) metabolism and has been associated with increased self-renewal characteristics in gliomas. Increased CcO activity in tumors has been associated with tumor progression after chemotherapy failure, and patients with primary glioblastoma multiforme and high tumor CcO activity have worse clinical outcomes than those with low tumor CcO activity...
November 11, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27633738/modeling-the-detailed-kinetics-of-mitochondrial-cytochrome-c-oxidase-catalytic-mechanism-and-nitric-oxide-inhibition
#16
Venkat R Pannala, Amadou K S Camara, Ranjan K Dash
Cytochrome c oxidase (CcO) catalyzes the exothermic reduction of O2 to H2O by using electrons from cytochrome c, and hence plays a crucial role in ATP production. Although details on the enzyme structure and redox centers involved in O2 reduction have been known, there still remains a considerable ambiguity on its mechanism of action, e.g., the number of sequential electrons donated to O2 in each catalytic step, the sites of protonation and proton pumping, and nitric oxide (NO) inhibition mechanism. In this work, we developed a thermodynamically constrained mechanistic mathematical model for the catalytic action of CcO based on available kinetic data...
November 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27614312/molecular-cloning-and-expression-analysis-of-cytochrome-c-oxidase-subunit-ii-from-sitophilus-zeamais
#17
Chang-Liang Hou, Jing-Bo Wang, Hua Wu, Jia-Yu Liu, Zhi-Qing Ma, Jun-Tao Feng, Xing Zhang
Cytochrome c oxidase subunit II (COX II) containing a dual core CuA active site is one of the core subunits of mitochondrial Cytochrome c oxidase (Cco), which plays a significant role in the physiological process. In this report, the full-length cDNA of COXII gene was cloned from Sitophilus zeamais, which had an open reading frame (ORF) of 684 bp encoding 227 amino acids residues. The predicted COXII protein had a molecular mass of 26.2 kDa with pI value of 6.37. multiple sequence alignment and phylogenetic analysis indicated that Sitophilus zeamais COXII had high sequence identity with the COXII of other insect species...
September 30, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27605664/the-mg2-containing-water-cluster-of-mammalian-cytochrome-c-oxidase-collects-four-pumping-proton-equivalents-in-each-catalytic-cycle
#18
Naomine Yano, Kazumasa Muramoto, Atsuhiro Shimada, Shuhei Takemura, Junpei Baba, Hidenori Fujisawa, Masao Mochizuki, Kyoko Shinzawa-Itoh, Eiki Yamashita, Tomitake Tsukihara, Shinya Yoshikawa
Bovine heart cytochrome c oxidase (CcO) pumps four proton equivalents per catalytic cycle through the H-pathway, a proton-conducting pathway, which includes a hydrogen bond network and a water channel operating in tandem. Protons are transferred by H3O(+) through the water channel from the N-side into the hydrogen bond network, where they are pumped to the P-side by electrostatic repulsion between protons and net positive charges created at heme a as a result of electron donation to O2 bound to heme a3 To block backward proton movement, the water channel remains closed after O2 binding until the sequential four-proton pumping process is complete...
November 11, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27605642/oregon-s-coordinated-care-organizations-increased-timely-prenatal-care-initiation-and-decreased-disparities
#19
Ifeoma Muoto, Jeff Luck, Jangho Yoon, Stephanie Bernell, Jonathan M Snowden
Policies at the state and federal levels affect access to health services, including prenatal care. In 2012 the State of Oregon implemented a major reform of its Medicaid program. The new model, called a coordinated care organization (CCO), is designed to improve the coordination of care for Medicaid beneficiaries. This reform effort provides an ideal opportunity to evaluate the impact of broad financing and delivery reforms on prenatal care use. Using birth certificate data from Oregon and Washington State, we evaluated the effect of CCO implementation on the probability of early prenatal care initiation, prenatal care adequacy, and disparities in prenatal care use by type of insurance...
September 1, 2016: Health Affairs
https://www.readbyqxmd.com/read/27571294/multicenter-osteopathic-pneumonia-study-in-the-elderly-subgroup-analysis-on-hospital-length-of-stay-ventilator-dependent-respiratory-failure-rate-and-in-hospital-mortality-rate
#20
Donald R Noll, Brian F Degenhardt, Jane C Johnson
CONTEXT: Osteopathic manipulative treatment (OMT) is a promising adjunctive treatment for older adults hospitalized for pneumonia. OBJECTIVE: To report subgroup analyses from the Multicenter Osteopathic Pneumonia Study in the Elderly (MOPSE) relating to hospital length of stay (LOS), ventilator-dependent respiratory failure rate, and in-hospital mortality rate. DESIGN: Multicenter randomized controlled trial. SETTING: Seven community hospitals...
September 1, 2016: Journal of the American Osteopathic Association
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