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https://www.readbyqxmd.com/read/28992020/rapid-communication-dietary-selenium-improves-skeletal-muscle-mitochondrial-biogenesis-in-young-equine-athletes
#1
S H White, S Wohlgemuth, C Li, L K Warren
Exercise is known to promote mitochondrial biogenesis in skeletal muscle as well as enhance mitochondrial function and efficiency in human and rodent models. These adaptations help to decrease exercise-associated production of reactive oxygen species, which can negatively affect health and performance if antioxidant mechanisms are overwhelmed. Little is known about the adaptations of mitochondria in response to exercise training in the growing horse or if supplementation with a dietary antioxidant can improve mitochondrial function...
September 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28988874/regulation-of-mammalian-13-subunit-cytochrome-c-oxidase-and-binding-of-other-proteins-role-of-ndufa4
#2
REVIEW
Bernhard Kadenbach
Cytochrome c oxidase (CcO) is the final oxygen accepting enzyme complex (complex IV) of the mitochondrial respiratory chain. In contrast to the other complexes (I, II, and III), CcO is highly regulated via isoforms for six of its ten nuclear-coded subunits, which are differentially expressed in species, tissues, developmental stages, and cellular oxygen concentrations. Recent publications have claimed that NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4 (NDUFA4), originally identified as subunit of complex I, represents a 14th subunit of CcO...
October 5, 2017: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/28973914/cavity-hydration-dynamics-in-cytochrome-c-oxidase-and-functional-implications
#3
Chang Yun Son, Arun Yethiraj, Qiang Cui
Cytochrome c oxidase (CcO) is a transmembrane protein that uses the free energy of O2 reduction to generate the proton concentration gradient across the membrane. The regulation of competitive proton transfer pathways has been established to be essential to the vectorial transport efficiency of CcO, yet the underlying mechanism at the molecular level remains lacking. Recent studies have highlighted the potential importance of hydration-level change in an internal cavity that connects the proton entrance channel, the site of O2 reduction, and the putative proton exit route...
October 2, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28970047/transcriptomic-analysis-reveals-differentially-expressed-genes-and-a-unique-apoptosis-pathway-in-channel-catfish-ovary-cells-after-infection-with-the-channel-catfish-virus
#4
Farman Ullah Dawar, Xianqin Hu, Lijuan Zhao, Xingxing Dong, Yang Xiong, Meng Zhou, Rishen Liang, V Sarath Babu, Jun Li, Jie Mei, Li Lin
The channel catfish virus (CCV) can cause lethal hemorrhagic infection in juvenile channel catfish, thereby resulting in a huge economic loss to the fish industry. The genome of the CCV has been fully sequenced, and its prevalence is well documented. However, less is known about the molecular mechanisms and pathogenesis of the CCV. Herein, the channel catfish ovary cells (CCO) were infected with CCV and their transcriptomic sketches were analyzed using an RNA sequencing technique. In total, 72,686,438 clean reads were obtained from 73,231,128 sequence reads, which were further grouped into 747,168 contigs...
September 29, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28949271/pressure-passivity-of-cerebral-mitochondrial-metabolism-is-associated-with-poor-outcome-following-perinatal-hypoxic-ischemic-brain-injury
#5
Subhabrata Mitra, Gemma Bale, David Highton, Roxanna Gunny, Cristina Uria-Avellanal, Alan Bainbridge, Magdalena Sokolska, David Price, Angela Huertas-Ceballos, Giles S Kendall, Judith Meek, Ilias Tachtsidis, Nicola J Robertson
Hypoxic ischemic encephalopathy (HIE) leads to significant morbidity and mortality. Impaired autoregulation after hypoxia-ischaemia has been suggested to contribute further to injury. Thalamic lactate/N-Acetylasperate (Lac/NAA) peak area ratio of > 0.3 on proton ((1)H) magnetic resonance spectroscopy (MRS) is associated with poor neurodevelopment outcome following HIE. Cytochrome-c-oxidase (CCO) plays a central role in mitochondrial oxidative metabolism and ATP synthesis. Using a novel broadband NIRS system, we investigated the impact of pressure passivity of cerebral metabolism (CCO), oxygenation (haemoglobin difference (HbD)) and cerebral blood volume (total haemoglobin (HbT)) in 23 term infants following HIE during therapeutic hypothermia (HT)...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28946353/application-of-propyl-gallate-alleviates-pericarp-browning-in-harvested-longan-fruit-by-modulating-metabolisms-of-respiration-and-energy
#6
Yifen Lin, Yixiong Lin, Hetong Lin, Yihui Chen, Hui Wang, John Shi
Effects of propyl gallate on metabolisms of respiration and energy of harvested 'Fuyan' longans and its relationship to pericarp browning were investigated. Compared to control longans, propyl gallate could reduce ascorbic acid oxidase (AAO) activity, lower cytochrome C oxidase (CCO) activity during early-storage and mid-storage, increase NADK activity, elevate contents of NADP and NADPH, decrease contents of NAD and NADH, in addition, lower the decreases of ATP content and energy charge (E.C.), increase activities of mitochondrial H(+)-ATPase, Ca(2+)-ATPase and Mg(2+)-ATPase during early-storage and mid-storage...
February 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28940516/analysis-of-clonal-expansions-through-the-normal-and-premalignant-human-breast-epithelium-reveals-the-presence-of-luminal-stem-cells
#7
Biancastella Cereser, Marnix Jansen, Emily Austin, George Elia, Taneisha McFarlane, Carolien Hm van Deurzen, Anieta M Sieuwerts, Maria G Daidone, Paul J Tadrous, Nicholas A Wright, Louise Jones, Stuart Ac McDonald
It is widely accepted that the cell of origin of breast cancer is the adult mammary epithelial stem cell, however demonstrating the presence and location of tissue stem cells in the human breast has proved difficult. Furthermore, we do not know the clonal architecture of the normal and premalignant mammary epithelium or its cellular hierarchy. Here we use deficiency in the mitochondrial enzyme cytochrome c oxidase (CCO), typically caused by somatic mutations in the mitochondrial genome, as a means to perform lineage tracing in the human mammary epithelium...
September 22, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28913995/intraoperatively-observed-lacrimal-obstructive-features-and-surgical-outcomes-in-external-dacryocystorhinostomy
#8
Min Joung Lee, Sang In Khwarg, In Hyuk Kim, Jeong Hoon Choi, Youn Joo Choi, Namju Kim, Ho Kyung Choung
PURPOSE: To analyze the features of lacrimal drainage system obstruction confirmed during external dacryocystorhinostomy surgeries and report the surgical outcomes. METHODS: We reviewed the medical records of a total of 769 cases who underwent external dacryocystorhinostomy for primary lacrimal drainage obstruction between 2005 and 2014. Data about detailed location and extent of obstruction were collected intraoperatively. The sites of obstruction were classified into nasolacrimal duct obstruction (NLDO), common canalicular obstruction (CCO), and canalicular obstruction...
October 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/28866381/cytochrome-c-oxidase-inhibition-by-calcium-at-physiological-ionic-composition-of-the-medium-implications-for-physiological-significance-of-the-effect
#9
Tatiana V Vygodina, Elizaveta Mukhaleva, Natalia V Azarkina, Alexander A Konstantinov
Cytochrome c oxidase (CcO) from mammalian mitochondria binds Ca(2+) and Na(+) in a special cation binding site. Binding of Ca(2+) brings about partial inhibition of the enzyme while Na(+) competes with Ca(2+) for the binding site and protects the enzyme from the inhibition [Vygodina, T., Kirichenko, A. and Konstantinov, A.A. (2013). Direct Regulation of Cytochrome c oxidase by Calcium Ions. PLoS One 8(9): e74436]. In the original studies, the inhibition was found to depend significantly on the ionic composition of the buffer...
September 1, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28862974/clostridial-collagenase-for-the-management-of-diabetic-foot-ulcers-results-of-four-randomized-controlled-trials
#10
John C Lantis Ii, Ian Gordon
BACKGROUND: Despite major treatment advances, diabetic foot ulcers (DFUs) remain a frequent and debilitating complication of diabetes mellitus and a major cause of significant morbidity and mortality. OBJECTIVE: This study evaluates and compares clinical effectiveness of clostridial collagenase ointment (CCO) with standard care (SC) in patients with DFUs, with the goal to define best clinical criteria under which to use CCO in the DFU population. MATERIALS AND METHODS: This is a pooled data analysis of 4 randomized controlled trials that compared clinical effectiveness of CCO to SC...
August 25, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28860830/economic-analysis-and-budget-impact-of-clostridial-collagenase-ointment-compared-with-medicinal-honey-for-treatment-of-pressure-ulcers-in-the-us
#11
Elizabeth S Mearns, Michael Liang, Brendan L Limone, Adrienne M Gilligan, Jeffrey D Miller, Kathleen D Schaum, Curtis R Waycaster
OBJECTIVES: Pressure ulcer (PU) treatment poses significant clinical and economic challenges to health-care systems. The aim of this study was to assess the cost-effectiveness and budget impact of enzymatic debridement with clostridial collagenase ointment (CCO) compared with autolytic debridement with medicinal honey (MH) for PU treatment from a US payer/Medicare perspective in the hospital outpatient department setting. METHODS: A cost-effectiveness analysis using a Markov model was developed using a 1-week cycle length across a 1-year time horizon...
2017: ClinicoEconomics and Outcomes Research: CEOR
https://www.readbyqxmd.com/read/28860337/from-b-to-a-making-an-essential-cofactor-in-a-human-parasite
#12
COMMENT
Naomi S Morrissette, Celia W Goulding
Trypanosomatids are parasitic eukaryotic organisms that cause human disease. These organisms have complex lifestyles; cycling between vertebrate and insect hosts and alternating between two morphologies; a replicating form and an infective, nonreplicating one. Because trypanosomatids are one of the few organisms that do not synthesize the essential cofactor, heme, these parasites sequester the most common form, heme B, from their hosts. Once acquired, the parasites derivatize heme B to heme A by two sequential enzyme reactions...
August 30, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28842531/role-of-conformational-change-and-k-path-ligands-in-controlling-cytochrome-c-oxidase-activity
#13
REVIEW
Jian Liu, Carrie Hiser, Shelagh Ferguson-Miller
Given the central role of cytochrome c oxidase (CcO) in health and disease, it is an increasingly important question as to how the activity and efficiency of this key enzyme are regulated to respond to a variety of metabolic states. The present paper summarizes evidence for two modes of regulation of activity: first, by redox-induced conformational changes involving the K-proton uptake path; and secondly, by ligand binding to a conserved site immediately adjacent to the entrance of the K-path that leads to the active site...
August 24, 2017: Biochemical Society Transactions
https://www.readbyqxmd.com/read/28801051/the-mechanism-for-oxygen-reduction-in-cytochrome-c-dependent-nitric-oxide-reductase-cnor-as-obtained-from-a-combination-of-theoretical-and-experimental-results
#14
Margareta R A Blomberg, Pia Ädelroth
Bacterial NO-reductases (NOR) belong to the heme-copper oxidase (HCuO) superfamily, in which most members are O2-reducing, proton-pumping enzymes. This study is one in a series aiming to elucidate the reaction mechanisms of the HCuOs, including the mechanisms for cellular energy conservation. One approach towards this goal is to compare the mechanisms for the different types of HCuOs, cytochrome c oxidase (CcO) and NOR, reducing the two substrates O2 and NO. Specifically in this study, we describe the mechanism for oxygen reduction in cytochrome c dependent NOR (cNOR)...
August 8, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28794387/carotid-endarterectomy-with-routine-shunt-for-patients-with-contralateral-carotid-occlusion
#15
Jie Kong, Jinyong Li, Zhidong Ye, Xueqiang Fan, Jianyan Wen, Jianbin Zhang, Peng Liu
This study aimed to report the clinical features and early and long-term outcomes of patients treated with carotid endarterectomy (CEA) combined with a routine shunt for carotid stenosis with the occlusion of the contralateral carotid artery (CCO), and to compare them with patients without contralateral occlusion (NO-CCO). A retrospective analysis included 301 patients who had carotid artery stenosis treated with CEA using a routine shunt. Of these patients, 35 patients and 266 patients were categorized into a CCO group and NO-CCO group, respectively...
August 9, 2017: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28753305/mimicking-a-natural-enzyme-system-cytochrome-c-oxidase-like-activity-of-cu2o-nanoparticles-by-receiving-electrons-from-cytochrome-c
#16
Ming Chen, Zhonghua Wang, Jinxia Shu, Xiaohui Jiang, Wei Wang, Zhen-Hua Shi, Ying-Wu Lin
Inorganic nanomaterials-based artificial enzymes (nanozymes) have received considerable attention over the past years. However, the substrates studied for nanozymes have so far been limited to small organic molecules. The catalytic oxidation of biomacromolecules, such as proteins, by nanozymes has not yet been reported to date. In this study, we report that cuprous oxide nanoparticles (Cu2O NPs) possess cytochrome c oxidase (CcO)-like activity and catalyze the oxidation of cytochrome c (Cyt c), converting it from the ferrous state to the ferric state under atmospheric oxygen conditions...
July 28, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28740863/a-nanosecond-time-resolved-xfel-analysis-of-structural-changes-associated-with-co-release-from-cytochrome-c-oxidase
#17
Atsuhiro Shimada, Minoru Kubo, Seiki Baba, Keitaro Yamashita, Kunio Hirata, Go Ueno, Takashi Nomura, Tetsunari Kimura, Kyoko Shinzawa-Itoh, Junpei Baba, Keita Hatano, Yuki Eto, Akari Miyamoto, Hironori Murakami, Takashi Kumasaka, Shigeki Owada, Kensuke Tono, Makina Yabashi, Yoshihiro Yamaguchi, Sachiko Yanagisawa, Miyuki Sakaguchi, Takashi Ogura, Ryo Komiya, Jiwang Yan, Eiki Yamashita, Masaki Yamamoto, Hideo Ago, Shinya Yoshikawa, Tomitake Tsukihara
Bovine cytochrome c oxidase (CcO), a 420-kDa membrane protein, pumps protons using electrostatic repulsion between protons transferred through a water channel and net positive charges created by oxidation of heme a (Fe a ) for reduction of O2 at heme a3 (Fe a3). For this process to function properly, timing is essential: The channel must be closed after collection of the protons to be pumped and before Fe a oxidation. If the channel were to remain open, spontaneous backflow of the collected protons would occur...
July 2017: Science Advances
https://www.readbyqxmd.com/read/28720400/viewing-an-ultra-brief-chest-compression-only-video-improves-some-measures-of-bystander-cpr-performance-and-responsiveness-at-a-mass-gathering-event
#18
Daniel L Beskind, Uwe Stolz, Rebecca Thiede, Riley Hoyer, Whitney Robertson, Jeffrey Brown, Melissa Ludgate, Timothy Tiutan, Romy Shane, Deven McMorrow, Michael Pleasants, Karl B Kern, Ashish R Panchal
BACKGROUND: CPR training at mass gathering events is an important part of health initiatives to improve cardiac arrest survival. However, it is unclear whether training lay bystanders using an ultra-brief video at a mass gathering event improves CPR quality and responsiveness. OBJECTIVE: To determine if showing a chest-compression only (CCO) Ultra-Brief Video (UBV) at a mass gathering event is effective in teaching lay bystanders CCO-CPR. METHODS: Prospective control trial in adults (age >18) who attended either a women's University of Arizona or a men's Phoenix Suns basketball game...
September 2017: Resuscitation
https://www.readbyqxmd.com/read/28707373/biomarker-responses-and-pah-ratios-in-fish-inhabiting-an-estuarine-urban-waterway
#19
Rafael Mendonça Duarte, Helen Sadauskas-Henrique, Vera Maria Fonseca de Almeida-Val, Adalberto Luis Val, Helen Elizabeth Nice, Marthe Monique Gagnon
Many cities worldwide are established adjacent to estuaries and their catchments resulting in estuarine contamination due to intense anthropogenic activities. The aim of this study was to evaluate if fish living in an estuarine urban waterway were affected by contamination, via the measurement of a suite of biomarkers of fish health. Black bream (Acanthopagrus butcheri) were sampled in a small urban embayment and a suite of biomarkers of fish health measured. These were condition factor (CF), liver somatic index (LSI), gonadosomatic index (GSI), hepatic EROD activity, polycyclic aromatic hydrocarbon (PAH) biliary metabolites, serum sorbitol dehydrogenase (s-SDH) and branchial enzymes cytochrome C oxidase (CCO), and lactate dehydrogenase (LDH) activities...
October 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28702862/oregon-s-coordinated-care-organizations-and-their-effect-on-prenatal-care-utilization-among-medicaid-enrollees
#20
Lisa P Oakley, S Marie Harvey, Jangho Yoon, Jeff Luck
Introduction Previous studies indicate that inadequate prenatal care is more common among women covered by Medicaid compared with private insurance. Increasing the proportion of pregnant women who receive early and adequate prenatal care is a Healthy People 2020 goal. We examined the impact of the implementation of Oregon's accountable care organizations, Coordinated Care Organizations (CCOs), for Medicaid enrollees, on prenatal care utilization among Oregon women of reproductive age enrolled in Medicaid. Methods Using Medicaid eligibility data linked to unique birth records for 2011-2013, we used a pre-posttest treatment-control design that compared prenatal care utilization for women on Medicaid before and after CCO implementation to women never enrolled in Medicaid...
July 12, 2017: Maternal and Child Health Journal
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