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https://www.readbyqxmd.com/read/28407595/proteo-lipobeads-to-encapsulate-cytochrome-c-oxidase-from-paracoccus-denitrificans
#1
Andreas F Geiss, Christina Bliem, Pinar Frank, Ciril Reiner-Rozman, Justin Kewney, Michael Boersch, Renate L C Naumann
Proteo-lipobeads (PLBs) are investigated as cell-free model systems to encapsulate membrane proteins such as ion channels and transporters. PLBs are based on nickel nitrile tri-acetic acid (Ni-NTA)-functionalized agarose beads, onto which membrane proteins (MP) are bound via histidine(his)-tag. Composite beads thus obtained (subsequently called proteobeads) are dialyzed in the presence of lipid micelles to form PLBs. As an example we employed cytochrome c oxidase from P. denitrificans with a his-tag fused to the C-terminus of subunitI...
April 5, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28390808/morphological-characteristics-of-external-auditory-canal-in-congenital-aural-stenosis-patients
#2
Dongming Yin, Chenlong Li, Keguang Chen, Juan Hong, Jieying Li, Lin Yang, Tianyu Zhang, Peidong Dai
Objective To investigate characteristics of congenital aural stenosis (CAS) patients' external auditory canal (EAC) (position, length, orientation, etc.) and compare them with normal EAC. METHODS: CT images of normal people and CAS patient were utilized. We obtained coordinates of EAC landmarks. Then the Matlab program could calculate some anatomic parameters about EAC, including distances from central point of tympanic annulus (CA), central point of osseous EAC opening (CO), central point of cartilaginous EAC inside opening (CCi), central point of cartilaginous EAC outside opening (CCo) to the Frankfurt horizontal plane (Pfrkt), the median sagittal plane (Psag), the coronal plane (Pcor); orientations of EAC bendings; straight and arc lengths of EAC...
April 1, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28382074/inhibiting-cytochrome-c-oxidase-leads-to-alleviated-ischemia-reperfusion-injury
#3
Zhaoyun Yang, Zhongxin Duan, Tian Yu, Junmei Xu, Lei Liu
BACKGROUND AND OBJECTIVES: The overall purpose of this study was to investigate the role of cytochrome C oxidase (CcO) in preventing ischemia reperfusion-induced cardiac injury through gaseous signaling molecule pathways. MATERIALS AND METHODS: We used CcO inhibitor, potassium cyanide (KCN) to mimic the pre-treatment of gaseous signaling molecules in a global ischemia/reperfusion (IR) injury model in rats. Intracellular reactive oxygen species (ROS) was determined by measuring mitochondrial H2O2 and mitochondrial complex activity...
March 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/28357365/cox1-mutation-abrogates-need-for-cox23-in-cytochrome-c-oxidase-biogenesis
#4
Richard Dela Cruz, Mi-Young Jeong, Dennis R Winge
Cox23 is a known conserved assembly factor for cytochrome c oxidase, although its role in cytochrome c oxidase (CcO) biogenesis remains unresolved. To gain additional insights into its role, we isolated spontaneous suppressors of the respiratory growth defect in cox23∆ yeast cells. We recovered independent colonies that propagated on glycerol/lactate medium for cox23∆ cells at 37°C. We mapped these mutations to the mitochondrial genome and specifically to COX1 yielding an I(101)F substitution. The I(101)F Cox1 allele is a gain-of-function mutation enabling yeast to respire in the absence of Cox23...
June 30, 2016: Microbial Cell
https://www.readbyqxmd.com/read/28274170/protective-effects-of-cassia-tora-leaves-in-experimental-cataract-by-modulating-intracellular-communication-membrane-co-transporters-energy-metabolism-and-the-ubiquitin-proteasome-pathway
#5
V Sreelakshmi, Annie Abraham
CONTEXT: Cataract is the clouding of eye lens which causes impairment in vision and accounts for the leading factor of global blindness. Functional food-based prevention of cataract finds application in vision research because of its availability and easy access to all classes of the society. Cassia tora Linn. (Caesalpinaceae) is an edible plant mentioned in the traditional systems of medicine for whole body health, especially to the eyes. OBJECTIVE: The present study evaluates the potential of ethyl acetate fraction of Cassia tora leaves (ECT) on experimental cataract...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/28273124/blockade-of-cyclophilin-d-rescues-dexamethasone-induced-oxidative-stress-in-gingival-tissue
#6
Yuting He, Ling Zhang, Zhuoli Zhu, Anqi Xiao, Haiyang Yu, Xueqi Gan
Glucocorticoids (GCs) are frequently used for the suppression of inflammation in chronic inflammatory diseases. Excessive GCs usage is greatly associated with several side effects, including gingival ulceration, the downward migration of the epithelium, attachment loss and disruption of transeptal fibers. The mechanisms underlying GCs-induced impairments in gingival tissue remains poorly understood. Mitochondrial dysfunction is associated with various oral diseases, such as chronic periodontitis, age-related alveolar bone loss and hydrogen peroxide-induced cell injury in gingival...
2017: PloS One
https://www.readbyqxmd.com/read/28267678/enzymatic-debridement-of-chronic-nonischemic-diabetic-foot-ulcers-results-of-a-randomized-controlled-trial
#7
Juan Carlos Jimenez, Patrick S Agnew, Perry Mayer, John R Clements, Joseph M Caporusso, Darrell L Lange, Jaime E Dickerson, Herbert B Slade
OBJECTIVE: The aim of this randomized, controlled multicenter trial was to evaluate the clinical outcomes associated with the use of clostridial collagenase ointment (CCO) for up to 12 weeks in 215 patients with type 1 or type 2 diabetes mellitus and a neuropathic, nonischemic diabetic foot ulcer (DFU). MATERIALS AND METHODS: Patients were randomized into either a group receiving CCO applied once daily at a thickness of ~2 mm or a group receiving standard care (SC) consisting of a daily application of a hydrogel as needed to maintain a moist ulcer environment...
February 27, 2017: Wounds: a Compendium of Clinical Research and Practice
https://www.readbyqxmd.com/read/28262300/invasive-mediastinal-staging-guideline%C3%A2-concordance
#8
Anna Bendzsak, Thomas K Waddell, Kazuhiro Yasufuku, Shaf Keshavjee, Marc de Perrot, Marcelo Cypel, Andrew F Pierre, Gail E Darling
BACKGROUND: Despite guidelines for preoperative invasive mediastinal staging (IMS) for non-small cell lung cancer (NSCLC), concordance with guidelines and whether the use of these guidelines results in expected frequency of lymph node metastases has not been evaluated. Our objectives were to determine guideline concordance, reasons for nonconcordance, and, in patients who did not receive IMS, to determine the use of operative nodal sampling and final pathologic staging. METHODS: Patients who had a resection for NSCLC between 2010 and 2012 were identified from the Institutional Cancer Registry...
March 2, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/28242320/a-positive-feedback-loop-between-nitric-oxide-and-amyloid-%C3%AE-1-42-accelerates-mitochondrial-damage-in-human-lens-epithelial-cells
#9
Noriaki Nagai, Yoshimasa Ito, Teppei Shibata, Eri Kubo, Hiroshi Sasaki
We have reported that excessive nitric oxide (NO), like other reactive oxygen species (ROS), causes a decrease in cytochrome c oxidase (CCO) activity and ATP levels (mitochondrial damage) resulting in lens opacity. In addition, previous reports have shown that oxidative stress caused by ROS enhances amyloid β (Aβ) production in mammalian lenses, and that Aβ1-42 stimulates inducible nitric oxide synthase (iNOS) promoter activity. Based on these reports, we investigated the relationship between NO and Aβ1-42 production in human lens epithelial (HLE) cells...
April 15, 2017: Toxicology
https://www.readbyqxmd.com/read/28240158/biodiesel-production-from-citrillus-colocynthis-oil-using-based-catalytic-reaction-and-characterization-studies
#10
Imededdine A Nehdi, Hassen M Sbihi, Lahssen El Blidi, Umer Rashid, Saud I Al-Resayes
In this investigation, an enzyme catalyzed process was optimized to prepare methyl esters from crude Citrullus colocynthis oil (CCO). Novozym 435 was used to synthesize biodiesel by transesterification of CCO with methanol. Use of tert-butanol as a reaction medium eliminated negative effects caused by excess methanol and formation of glycerol byproduct. Several variables affecting the Citrullus colocynthis methyl ester (CCME) yield including lipase quantity, water content, methanol/oil mole ratio, reaction temperature, reaction medium composition, and reaction time were optimized...
February 23, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28199277/funding-accountable-care-in-oregon-financial-models-in-two-coordinated-care-organizations
#11
Lauren Broffman, Kristin Brown, Bruce K Bayley, Lucy Savitz, Jill Rissi
Oregon's coordinated care organizations (CCOs) are an integral part of a massive statewide reform that brings accountable care to Medicaid. CCOs are regional collaboratives among health plans, providers, county public health, and communitybased organizations that administer a single global budget covering physical, mental, and dental healthcare for low-income Oregonians. CCOs have been given freedom within the global budget to implement reforms that might capture efficiencies in cost and quality. For this study-fielded between 2012 and 2015-we traced the path of the global budget through the interior structures of two of Oregon's most promising CCOs...
July 2016: Journal of Healthcare Management / American College of Healthcare Executives
https://www.readbyqxmd.com/read/28190514/transluminal-attenuation-gradient-and-corrected-models-in-coronary-ct-angiography-for-determining-stenosis-severity-a-primary-study-using-dual-source-ct
#12
K Peng, N Xu, L Zhang, F Xiao, N Indima, J Zhang, Y Shen, W Peng, G Tang
AIM: To compare the incremental value of transluminal attenuation gradient (TAG), TAG with corrected contrast opacification (TAG-CCO), and TAG with exclusion of calcified coronary segments (TAG-ExC) in determining the stenosis severity of coronary arteries using coronary angiography (CAG) as the reference standard. MATERIALS AND METHODS: One hundred and fifteen patients who underwent computed tomography coronary angiography (CTCA) and confirmed by coronary angiography (CAG) were included in the retrospective analysis...
February 9, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28178891/up-regulation-of-cerebral-cytochrome-c-oxidase-and-hemodynamics-by-transcranial-infrared-laser-stimulation-a-broadband-near-infrared-spectroscopy-study
#13
Xinlong Wang, Fenghua Tian, Divya D Reddy, Sahil S Nalawade, Douglas W Barrett, Francisco Gonzalez-Lima, Hanli Liu
Transcranial infrared laser stimulation (TILS) is a noninvasive form of brain photobiomulation. Cytochrome-c-oxidase (CCO), the terminal enzyme in the mitochondrial electron transport chain, is hypothesized to be the primary intracellular photoacceptor. We hypothesized that TILS up-regulates cerebral CCO and causes hemodynamic changes. We delivered 1064-nm laser stimulation to the forehead of healthy participants ( n = 11), while broadband near-infrared spectroscopy was utilized to acquire light reflectance from the TILS-treated cortical region before, during, and after TILS...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28152942/communities-of-practice-a-jurisdictional-approach-to-improving-the-quality-of-care-in-radiation-medicine-in-ontario
#14
Michelle Ang, Lindsay Elizabeth Reddeman, Michael Sharpe, Margaret Hart, Carina Simniceanu, Stephen Breen, Joon-Hyung J Kim, Dani Scott, Khaled Zaza, David D'Souza, Michael F Milosevic, Stewart Gaede, Andrea Marshall, Brian P Yaremko, Katharina Sixel, Nicole Harnett, Eric Gutierrez, Padraig Richard Warde
122 Background: The Radiation Treatment Program (RTP) at Cancer Care Ontario (CCO) established several Communities of Practice (CoPs), with the goal of improving radiation treatment (RT) quality and safety. The RTP identifies variation in practice and quality improvement (QI) opportunities in the 14 Regional Cancer Centres (RCCs) and facilitates the development of CoPs to share best practices and standardize care. METHODS: Since 2010, the RTP has formed 7 CoPs ( > 185 members in total): 4 intra-disciplinary (Radiation Therapy, Medical Physics, Advanced Practice Radiation Therapy, Radiation Safety) and 3 inter-disciplinary (Head and Neck (HN), Gynecological (GYNE) and Lung Cancer)...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152935/optimizing-the-collection-and-reporting-of-wait-time-data
#15
Deanna Langer, Melissa Kaan, Jonathan Norton, Brian Ho, Ann Thomas, Julian Dobranowski
121 Background: Wait times for critical interventional radiology (IR) procedures have long been reported as barriers to access for cancer patients. Wait times have been difficult to measure in the province of Ontario as no mechanisms exist to capture IR data. Three individual programs at Cancer Care Ontario (CCO) began collection of CT-guided biopsies wait time data, with nuances dependent on program area of focus. The Cancer Imaging Program collects appointment availability for lung biopsies through a monthly email survey...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152934/an-approach-to-implementing-meaningful-change-in-a-provincial-health-care-system
#16
Elizabeth Lockhart, Michael Donald Brundage, Margaret Hart, Mark Hartman, Sophie Foxcroft, Lindsay Elizabeth Reddeman, Carina Simniceanu, Marissa Mendelsohn, Lisa Favell, Jonathan Wang, Elaine Meertens, Eric Gutierrez, Padraig Richard Warde
120 Background: Radiation treatment (RT) is essential to cancer management, contributing to cure and symptom control. With increasing cancer incidence and treatment complexity, health systems must adapt to ensure patients (pts) receive the highest quality of care. METHODS: With the objective of ensuring equitable access to high-quality, safe care, Cancer Care Ontario (CCO), a provincial government agency, identified provincial variability in RT activities. As a result, CCO prioritized 3 quality initiatives over the past 7 years: 1) Access to Intensity Modulated RT (IMRT) (2008-2013); 2) Peer Review of RT plans due to increasing RT planning complexity and the existence of high-profile RT errors (2012-present); and 3) Ensuring equitable access to RT (RT Utilization) (2014-present)...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152922/psychosocial-oncology-quality-indicators-prioritization-exercise
#17
Zahra Ismail, Lesley Moody, Maria Rugg
277 Background: One of Cancer Care Ontario's (CCO) roles is to monitor and report on cancer system performance to support quality improvement. CCO's Psychosocial Oncology (PSO) program developed a measurement plan with potential indicators to evaluate patient access to and the effectiveness of PSO services across the province. The objective of this study was to conduct a modified Delphi process to build consensus and prioritize PSO indicators based on their relevance to provincial goals, ability to measure regional and provincial performance and result in tangible actions...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152875/validation-of-a-real-time-patient-reported-experience-measurement-tool-for-cancer-patients-in-ontario
#18
Sarah Benn, Luciano Ieraci, Saurabh Ingale, Simron Singh
174 Background: Cancer Care Ontario (CCO) organizes and ensures quality cancer care for 16 million residents in Ontario. CCO's goal is to create a tool to enable reporting of the patient experience in real time. The study objective was to develop a validated real-time (close to or at point of care) patient reported experience measurement (PREM) tool to drive quality improvement, advance system planning and ensure cost effective resource allocation based on patients' needs, wants and preferences in ambulatory oncology treatment phase...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152855/cervical-screening-reminder-calls-pilot-utilizing-emrs-to-improve-cancer-screening
#19
Aaron Randall
163 Background: Cancer screening detects pre-cancerous changes, or cancer at an early stage when there is a better chance of treating it successfully. Research shows that that physician encouragement improves the odds of patients getting screened. Furthermore, systematic reviews demonstrate that efforts to encourage screening can be more effective through telephone reminders when compared to other methods of outreach. Electronic Medical Records (EMRs) are a powerful tool for the coordination, recording, monitoring and reporting of patient care in primary care...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28152845/standardizing-architecture-and-governance-of-radiology-clinical-checklist-development
#20
Priyanka Jain, Deanna Langer, David Kwan, Julian Dobranowski
193 Background: To improve quality of radiology reporting, Cancer Care Ontario's (CCO) Cancer Imaging Program established synoptic radiology reporting as a priority area. Program goals are to implement standardized radiology reports across the province, improving communication between referring and interpreting physicians and providing a standardized foundation for staging data collection and population health research. Although there are libraries of structured radiology clinical checklists, development methodologies quality vary...
March 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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