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https://www.readbyqxmd.com/read/28707373/biomarker-responses-and-pah-ratios-in-fish-inhabiting-an-estuarine-urban-waterway
#1
Rafael Mendonça Duarte, Helen Sadauskas-Henrique, Vera Maria Fonseca de Almeida-Val, Adalberto Luis Val, Helen Elizabeth Nice, Marthe Monique Gagnon
Many cities worldwide are established adjacent to estuaries and their catchments resulting in estuarine contamination due to intense anthropogenic activities. The aim of this study was to evaluate if fish living in an estuarine urban waterway were affected by contamination, via the measurement of a suite of biomarkers of fish health. Black bream (Acanthopagrus butcheri) were sampled in a small urban embayment and a suite of biomarkers of fish health measured. These were condition factor (CF), liver somatic index (LSI), gonadosomatic index (GSI), hepatic EROD activity, polycyclic aromatic hydrocarbon (PAH) biliary metabolites, serum sorbitol dehydrogenase (s-SDH) and branchial enzymes cytochrome C oxidase (CCO), and lactate dehydrogenase (LDH) activities...
July 14, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28702862/oregon-s-coordinated-care-organizations-and-their-effect-on-prenatal-care-utilization-among-medicaid-enrollees
#2
Lisa P Oakley, S Marie Harvey, Jangho Yoon, Jeff Luck
Introduction Previous studies indicate that inadequate prenatal care is more common among women covered by Medicaid compared with private insurance. Increasing the proportion of pregnant women who receive early and adequate prenatal care is a Healthy People 2020 goal. We examined the impact of the implementation of Oregon's accountable care organizations, Coordinated Care Organizations (CCOs), for Medicaid enrollees, on prenatal care utilization among Oregon women of reproductive age enrolled in Medicaid. Methods Using Medicaid eligibility data linked to unique birth records for 2011-2013, we used a pre-posttest treatment-control design that compared prenatal care utilization for women on Medicaid before and after CCO implementation to women never enrolled in Medicaid...
July 12, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28698372/crystal-structure-of-co-bound-cytochrome-c-oxidase-determined-by-serial-femtosecond-x-ray-crystallography-at-room-temperature
#3
Izumi Ishigami, Nadia A Zatsepin, Masahide Hikita, Chelsie E Conrad, Garrett Nelson, Jesse D Coe, Shibom Basu, Thomas D Grant, Matthew H Seaberg, Raymond G Sierra, Mark S Hunter, Petra Fromme, Raimund Fromme, Syun-Ru Yeh, Denis L Rousseau
Cytochrome c oxidase (CcO), the terminal enzyme in the electron transfer chain, translocates protons across the inner mitochondrial membrane by harnessing the free energy generated by the reduction of oxygen to water. Several redox-coupled proton translocation mechanisms have been proposed, but they lack confirmation, in part from the absence of reliable structural information due to radiation damage artifacts caused by the intense synchrotron radiation. Here we report the room temperature, neutral pH (6.8), damage-free structure of bovine CcO (bCcO) in the carbon monoxide (CO)-bound state at a resolution of 2...
July 11, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28695851/structure-of-bovine-cytochrome-c-oxidase-crystallized-at-a-neutral-ph-using-a-fluorinated-detergent
#4
Fangjia Luo, Kyoko Shinzawa-Itoh, Kaede Hagimoto, Atsuhiro Shimada, Satoru Shimada, Eiki Yamashita, Shinya Yoshikawa, Tomitake Tsukihara
Cytochrome c oxidase (CcO) couples proton pumping to O2 reduction. Its enzymatic activity depends sensitively on pH over a wide range. However, owing to difficulty in crystallizing this protein, X-ray structure analyses of bovine CcO aimed at understanding its reaction mechanism have been conducted using crystals prepared at pH 5.7, which is significantly lower than that in the cell. Here, oxidized CcO at pH 7.3 was crystallized using a fluorinated octyl-maltoside derivative, and the structure was determined at 1...
July 1, 2017: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/28685251/corrected-coronary-opacification-decrease-from-coronary-computed-tomography-angiography-validation-with-quantitative-13n-ammonia-positron-emission-tomography
#5
Dominik C Benz, Christoph Gräni, Paola Ferro, Luis Neumeier, Michael Messerli, Mathias Possner, Olivier F Clerc, Catherine Gebhard, Oliver Gaemperli, Aju P Pazhenkottil, Philipp A Kaufmann, Ronny R Buechel
BACKGROUND: To assess the functional relevance of a coronary artery stenosis, corrected coronary opacification (CCO) decrease derived from coronary computed tomography angiography (CCTA) has been proposed. The present study aims at validating CCO decrease with quantitative 13N-ammonia positron emission tomography (PET) myocardial perfusion imaging (MPI). METHODS AND RESULTS: This retrospective study consists of 39 patients who underwent hybrid CCTA/PET-MPI. From CCTA, attenuation in the coronary lumen was measured before and after a stenosis and corrected to the aorta to calculate CCO and its decrease...
July 6, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28655552/the-impact-of-contralateral-carotid-artery-stenosis-on-outcomes-after-carotid-endarterectomy
#6
Alexander B Pothof, Peter A Soden, Margriet Fokkema, Sara L Zettervall, Sarah E Deery, Thomas C F Bodewes, Gert J de Borst, Marc L Schermerhorn
OBJECTIVE: Patients with contralateral carotid occlusion (CCO) have been excluded from randomized clinical trials because of a deemed high risk for adverse neurologic outcomes with carotid endarterectomy (CEA). Evidence for this rationale is limited and conflicting. Therefore, we aimed to compare outcomes after CEA between patients with and without CCO and varying degrees of contralateral carotid stenosis (CCS). METHODS: We identified patients undergoing CEA from 2003 to 2015 in the Vascular Study Group of New England (VSGNE) registry...
June 24, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28647285/contrasting-patterns-of-energy-metabolism-in-northern-vs-southern-peripheral-european-flounder-populations-exposed-to-temperature-rising-and-hypoxia
#7
Nicolas Pédron, Jessy Le Du, Grégory Charrier, José-Luis Zambonino-Infante, Nicolas Le Bayon, Rita P Vasconcelos, Vanessa F Fonseca, Fabienne Le Grand, Jean Laroche
A two months common garden experiment was carried out to explore the potential differences of energy metabolism in northern core (France, 50°N and 47°N) vs southern peripheral (Portugal, 41°N) populations of European flounder Platichthys flesus, submitted to cold condition (CC: water temperature = 10 °C) and to warm and hypoxic condition (WHC: water temperature = 22 °C, and moderate hypoxia with O2 saturation = 40% during the last 6 days). Convergent growth rates (in length) were observed in the different populations and conditions, when the southern peripheral population of Portugal did not grow under cold conditions...
June 15, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28617536/effects-of-mulberry-leaf-polysaccharide-on-oxidative-stress-in-pancreatic-%C3%AE-cells-of-type-2-diabetic-rats
#8
C-G Liu, Y-P Ma, X-J Zhang
OBJECTIVE: To explore and discuss the effects and mechanisms of mulberry leaf polysaccharide (MLP) on oxidative stress in pancreatic β-cells of type 2 diabetic rats. MATERIALS AND METHODS: The model of diabetic rats was established by inducing the Sprague-Dawley (SD) rats with high-sugar and high-fat diet for 6 weeks and then giving them streptozotocin (STZ) by single intraperitoneal injection. The mulberry leaf polysaccharide was administered via gavage daily for 8 weeks, and the tissue morphology was observed through electron microscopy...
May 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28599236/raman-and-infrared-spectroscopy-of-carbohydrates-a-review
#9
REVIEW
Ewelina Wiercigroch, Ewelina Szafraniec, Krzysztof Czamara, Marta Z Pacia, Katarzyna Majzner, Kamila Kochan, Agnieszka Kaczor, Malgorzata Baranska, Kamilla Malek
Carbohydrates are widespread and naturally occurring compounds, and essential constituents for living organisms. They are quite often reported when biological systems are studied and their role is discussed. However surprisingly, up till now there is no database collecting vibrational spectra of carbohydrates and their assignment, as has been done already for other biomolecules. So, this paper serves as a comprehensive review, where for selected 14 carbohydrates in the solid state both FT-Raman and ATR FT-IR spectra were collected and assigned...
May 24, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28597738/improved-diagnostic-accuracy-when-combining-computed-tomography-angiography-and-corrected-coronary-opacification-in-patients-with-coronary-stents
#10
Taylor F Dowsley, Leonid Chepelev, Brian McArdle, Mohammed Alam, Girish Dwivedi, Benjamin J W Chow
Background The accuracy of coronary computed tomography angiography (CCTA) is sub-optimal in patients with coronary stents. Methods that can increase its diagnostic accuracy are desirable. Objective A proof-of-concept study was undertaken to determine if corrected coronary opacification (CCO) differences can improve the accuracy of CCTA in stented coronary arteries. Methods PCI patients who underwent both CCTA and invasive coronary angiography (ICA) within 3 months were analyzed. Coronary luminal attenuation values (normalized to the aorta) were measured proximally and distally to coronary stents...
February 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/28592383/long-term-outcome-prediction-by-functional-parameters-derived-from-coronary-computed-tomography-angiography
#11
Dominik C Benz, Fran Mikulicic, Christoph Gräni, Dominic Moret, Mathias Possner, Olivier F Clerc, Annina A Studer Bruengger, Oliver Gaemperli, Ronny R Buechel, Aju P Pazhenkottil, Philipp A Kaufmann
BACKGROUND: Estimation of hemodynamic relevance of a coronary stenosis from coronary computed angiography (CCTA) has raised substantial interest. Recently, the corrected coronary opacification (CCO) decrease and the transluminal attenuation gradient (TAG) have been suggested as faster alternatives to the FFRCT. The aim of the study was to evaluate whether the diagnostic accuracy of CCO decrease and TAG translates into an added prognostic value in patients evaluated for coronary artery disease (CAD)...
May 24, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28570764/controllable-n-doped-cuco2-o4-c-film-as-a-self-supported-anode-for-ultrastable-sodium-ion-batteries
#12
Xiaojun Wang, Kangzhe Cao, Yijing Wang, Lifang Jiao
Rational synthesis of flexible electrodes is crucial to rapid growth of functional materials for energy-storage systems. Herein, a controllable fabrication is reported for the self-supported structure of CuCo2 O4 nanodots (≈3 nm) delicately inserted into N-doped carbon nanofibers (named as 3-CCO@C); this composite is first used as binder-free anode for sodium-ion batteries (SIBs). Benefiting from the synergetic effect of ultrasmall CuCo2 O4 nanoparticles and a tailored N-doped carbon matrix, the 3-CCO@C composite exhibits high cycling stability (capacity of 314 mA h g(-1) at 1000 mA g(-1) after 1000 cycles) and high rate capability (296 mA h g(-1) , even at 5000 mA g(-1) )...
June 1, 2017: Small
https://www.readbyqxmd.com/read/28568245/quality-metrics-and-systems-transformation-are-we-advancing-alcohol-and-drug-screening-in-primary-care
#13
Traci Rieckmann, Stephanie Renfro, Dennis McCarty, Robin Baker, K John McConnell
OBJECTIVE: To examine the influence of Oregon's coordinated care organizations (CCOs) and pay-for-performance incentive model on completion of screening and brief intervention (SBI) and utilization of substance use disorder (SUD) treatment services. DATA SOURCES/STUDY SETTING: Secondary analysis of Medicaid encounter data from 2012 to 2015 and semiannual qualitative interviews with stakeholders in CCOs. STUDY DESIGN: Longitudinal mixed-methods design with simultaneous data collection with equal importance...
May 31, 2017: Health Services Research
https://www.readbyqxmd.com/read/28536198/understanding-the-essential-proton-pumping-kinetic-gates-and-decoupling-mutations-in-cytochrome-c-oxidase
#14
Ruibin Liang, Jessica M J Swanson, Mårten Wikström, Gregory A Voth
Cytochrome c oxidase (CcO) catalyzes the reduction of oxygen to water and uses the released free energy to pump protons against the transmembrane proton gradient. To better understand the proton-pumping mechanism of the wild-type (WT) CcO, much attention has been given to the mutation of amino acid residues along the proton translocating D-channel that impair, and sometimes decouple, proton pumping from the chemical catalysis. Although their influence has been clearly demonstrated experimentally, the underlying molecular mechanisms of these mutants remain unknown...
June 6, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28531864/determination-of-volumetric-gas-liquid-mass-transfer-coefficient-of-carbon-monoxide-in-a-batch-cultivation-system-using-kinetic-simulations
#15
Nulee Jang, Muhammad Yasin, Shinyoung Park, Robert W Lovitt, In Seop Chang
A mathematical model of microbial kinetics was introduced to predict the overall volumetric gas-liquid mass transfer coefficient (kLa) of carbon monoxide (CO) in a batch cultivation system. The cell concentration (X), acetate concentration (Cace), headspace gas (Nco and [Formula: see text] ), dissolved CO concentration in the fermentation medium (Cco), and mass transfer rate (R) were simulated using a variety of kLa values. The simulated results showed excellent agreement with the experimental data for a kLa of 13/hr...
September 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28493664/structure-and-spectroscopy-of-alkene-cleaving-dioxygenases-containing-an-atypically-coordinated-non-heme-iron-center
#16
Xuewu Sui, Andrew C Weitz, Erik R Farquhar, Mohsen Badiee, Surajit Banerjee, Johannes von Lintig, Gregory P Tochtrop, Krzysztof Palczewski, Michael P Hendrich, Philip D Kiser
Carotenoid cleavage oxygenases (CCOs) are non-heme iron enzymes that catalyze scission of alkene groups in carotenoids and stilbenoids to form biologically important products. CCOs possess a rare four-His iron center whose resting-state structure and interaction with substrates are incompletely understood. Here, we address this knowledge gap through a comprehensive structural and spectroscopic study of three phyletically diverse CCOs. The crystal structure of a fungal stilbenoid-cleaving CCO, CAO1, reveals strong similarity between its iron center and those of carotenoid-cleaving CCOs, but with a markedly different substrate-binding cleft...
June 6, 2017: Biochemistry
https://www.readbyqxmd.com/read/28490636/the-cox1-c-terminal-domain-is-a-central-regulator-of-cytochrome-c-oxidase-biogenesis-in-yeast-mitochondria
#17
Rodolfo García-Villegas, Yolanda Camacho-Villasana, Miguel Ángel Shingú-Vázquez, Alfredo Cabrera-Orefice, Salvador Uribe-Carvajal, Thomas D Fox, Xochitl Pérez-Martínez
Cytochrome c oxidase (CcO) is the last electron acceptor in the respiratory chain. The CcO core is formed by mitochondrial DNA-encoded Cox1, Cox2, and Cox3 subunits. Cox1 synthesis is highly regulated; for example, if CcO assembly is blocked, Cox1 synthesis decreases. Mss51 activates translation of COX1 mRNA and interacts with Cox1 protein in high-molecular-weight complexes (COA complexes) to form the Cox1 intermediary assembly module. Thus, Mss51 coordinates both Cox1 synthesis and assembly. We previously reported that the last 15 residues of the Cox1 C terminus regulate Cox1 synthesis by modulating an interaction of Mss51 with Cox14, another component of the COA complexes...
June 30, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28474287/evaluation-of-the-case-crossover-cco-study-design-for-adverse-drug-event-detection
#18
Zachary Burningham, Tao He, Chia-Chen Teng, Xi Zhou, Jonathan Nebeker, Brian C Sauer
INTRODUCTION: The case-crossover (CCO) design was originally intended to study exposures characterized as intermittent with acute effects. The performance of the CCO design is not well characterized under alternative exposure and outcome relationships. OBJECTIVE: The purpose of this study was to evaluate the ability of the CCO to identify simulated treatment effects under different drug exposures and outcomes relationships while varying the duration of the 1:1 matched risk and control windows...
May 4, 2017: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/28455961/repositioning-chlorpromazine-for-treating-chemoresistant-glioma-through-the-inhibition-of-cytochrome-c-oxidase-bearing-the-cox4-1-regulatory-subunit
#19
Claudia R Oliva, Wei Zhang, Cathy Langford, Mark J Suto, Corinne E Griguer
Patients with glioblastoma have one of the lowest overall survival rates among patients with cancer. Standard of care for patients with glioblastoma includes temozolomide and radiation therapy, yet 30% of patients do not respond to these treatments and nearly all glioblastoma tumors become resistant. Chlorpromazine is a United States Food and Drug Administration-approved phenothiazine widely used as a psychotropic in clinical practice. Recently, experimental evidence revealed the anti-proliferative activity of chlorpromazine against colon and brain tumors...
June 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28451469/comparative-effectiveness-of-clostridial-collagenase-ointment-to-medicinal-honey-for-treatment-of-pressure-ulcers
#20
Adrienne M Gilligan, Curtis R Waycaster, Richard Bizier, Bong-Chul Chu, Marissa J Carter, Caroline E Fife
Objective: Compare enzymatic debridement using clostridial collagenase ointment (CCO) with autolytic debridement using medicinal honey in the hospital outpatient setting for treating pressure ulcers (PUs). Approach: Retrospective deidentified electronic health records from 2007-2013 were extracted from the U.S. Wound Registry. Propensity score matching followed by multivariable analyses was used to adjust for selection bias and assess treatment effects comparing CCO-treated versus honey-treated PUs. Key outcomes included 100% granulation and epithelialization at 1 year...
April 1, 2017: Advances in Wound Care
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