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https://www.readbyqxmd.com/read/29435610/hydrogen-bonded-network-and-water-dynamics-in-the-d-channel-of-cytochrome-c-oxidase
#1
Tahereh Ghane, Rene F Gorriz, Sandro Wrzalek, Senta Volkenandt, Ferand Dalatieh, Marco Reidelbach, Petra Imhof
Proton transfer in cytochrome c oxidase (CcO) from the cellular inside to the binuclear redox centre as well as proton pumping through the membrane takes place through proton entrance via two distinct pathways, the D- and K-channel. Both channels show a dependence of their hydration level on the protonation states of their key residues, K362 for the K-channel, and E286 or D132 for the D-channel. In the oxidative half of CcO's catalytic cycle the D-channel is the proton-conducting path. For this channel, an interplay of protonation state of the D-channel residues with the water and hydrogen-bond dynamics has been observed in molecular dynamics simulations of the CcO protein, embedded in a lipid bi-layer, modelled in different protonation states...
February 12, 2018: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29429331/investigation-of-lipid-metabolism-by-a-new-structured-lipid-with-medium-and-long-chain-triacylglycerols-from-cinnamomum-camphora-seed-oil-in-healthy-c57bl-6j-mice
#2
Jiang-Ning Hu, Jin-Rong Shen, Chao-Yue Xiong, Xue-Mei Zhu, Ze-Yuan Deng
In the present study, a new structured lipid with medium- and long-chain triacylglycerols (MLCTs) was synthesized from camellia oil (CO) and Cinnamomum camphora seed oil (CCSO) by enzymatic interesterification. Meanwhile, the antiobesity effects of structured lipid were investigated through observing the changes of enzymes related to lipid mobilization in healthy C57BL/6J mice. Results showed that after synthesis, the major triacylgeride (TAG) species of intesterificated product changed to LaCC/CLaC (12.6 ± 0...
February 14, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29428329/three-year-clinical-results-of-carotid-artery-stenting-in-treating-patients-with-contralateral-carotid-artery-occlusion
#3
Jianming Guo, Lianrui Guo, Zhu Tong, Zhonggao Wang, Alan Dardik, Yongquan Gu
BACKGROUND: Patients presenting a carotid stenosis and contralateral carotid occlusion (CCO) have been historically considered at high risk of carotid surgical treatment, and there are few data regarding short-term recovery after stenting therapy in patients with CCO. The aim of this study is to evaluate the short-term recovery and safety of stenting for patients with CCO and different subgroup population. METHODS: We retrospectively reviewed the records of consecutive patients with CCO who were treated with stenting endovascular methods between 2008 and 2014...
February 8, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29408380/parent-child-feeding-practices-in-a-developing-country-findings-from-the-family-diet-study
#4
Wai Yew Yang, Tracy Burrows, Lesley MacDonald-Wicks, Lauren T Williams, Clare E Collins, Winnie Siew Swee Chee
BACKGROUND AND AIMS: Given the increasing prevalence of childhood obesity in Malaysia, examination of family environmental factors is warranted. Reviews from developed countries report inconsistent findings on the relationship between parental-child feeding practices and child weight-related health outcomes. The current study aimed to examine parent-child feeding practices by familial-child characteristics in Malaysia. MATERIALS AND METHOD: The Family Diet Study was conducted with urban Malay families and included a child aged 8-12 years and their main carer(s)...
February 2, 2018: Appetite
https://www.readbyqxmd.com/read/29400318/structure-of-bovine-cytochrome-c-oxidase-in-the-ligand-free-reduced-state-at-neutral-ph
#5
Fangjia Luo, Kyoko Shinzawa-Itoh, Kaede Hagimoto, Atsuhiro Shimada, Satoru Shimada, Eiki Yamashita, Shinya Yoshikawa, Tomitake Tsukihara
Cytochrome c oxidase (CcO), the terminal oxidase in cellular respiration, couples proton pumping to O2 reduction. Mammalian CcO resides in the inner mitochondrial membrane. Previously, a model of H-pathway proton pumping was proposed based on various CcO crystal structures. However, all previously determined structures were solved using crystals obtained at pH 5.7, which differs from the environmental pH of CcO in the inner membrane. The structures of fully oxidized and ligand-free reduced CcO at pH 7.3 have now been determined...
February 1, 2018: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/29396798/the-involvement-of-cytochrome-c-oxidase-in-mitochondrial-fusion-in-primary-cultures-of-neonatal-rat-cardiomyocytes
#6
Wen Yin, Rui Li, Xiaorong Feng, Y James Kang
Cytochrome c oxidase (CCO) is a copper-dependent enzyme of mitochondrial respiratory chain. In pressure overload-induced cardiac hypertrophy, copper level and CCO activity are both depressed, along with disturbance in mitochondrial fusion and fission dynamics. Copper repletion leads to recovery of CCO activity and normalized mitochondrial dynamics. The present study was undertaken to define the link between CCO activity and mitochondrial dynamic changes. Primary cultures of neonatal rat cardiomyocytes were treated with phenylephrine to induce cell hypertrophy...
February 2, 2018: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29350917/oxygen-activation-and-energy-conservation-by-cytochrome-c-oxidase
#7
Mårten Wikström, Klaas Krab, Vivek Sharma
This review focuses on the type A cytochrome c oxidases (CcO), which are found in all mitochondria and also in several aerobic bacteria. CcO catalyzes the respiratory reduction of dioxygen (O2) to water by an intriguing mechanism, the details of which are fairly well understood today as a result of research for over four decades. Perhaps even more intriguingly, the membrane-bound CcO couples the O2 reduction chemistry to translocation of protons across the membrane, thus contributing to generation of the electrochemical proton gradient that is used to drive the synthesis of ATP as catalyzed by the rotary ATP synthase in the same membrane...
January 19, 2018: Chemical Reviews
https://www.readbyqxmd.com/read/29315517/role-of-respiratory-terminal-oxidases-in-the-extracellular-electron-transfer-ability-of-cyanobacteria
#8
Narendran Sekar, Jian Wang, Yan Zhou, Yi Fang, Yajun Yan, Ramaraja P Ramasamy
Cyanobacteria are used as anode catalysts in photo-bioelectrochemical cells to generate electricity in a sustainable, economic and environmental friendly manner using only water and sunlight. Though cyanobacteria (CB) possess unique advantage for solar energy conversion by virtue of its robust photosynthesis, they cannot efficiently perform extracellular electron transfer (EET). The reasons being, unlike dissimilatory metal reducing bacteria (that are usually exploited in microbial fuel cells to generate electricity), (1) CB do not possess any special features on their outer membrane to carry out EET and (2) the electrons generated in photosynthetic electron transport chain are channeled into competing respiratory pathways rather than to the anode...
January 8, 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29310575/a-comparison-of-estimators-from-self-controlled-case-series-case-crossover-design-and-sequence-symmetry-analysis-for-pharmacoepidemiological-studies
#9
Yoshinori Takeuchi, Tomohiro Shinozaki, Yutaka Matsuyama
BACKGROUND: Despite the frequent use of self-controlled methods in pharmacoepidemiological studies, the factors that may bias the estimates from these methods have not been adequately compared in real-world settings. Here, we comparatively examined the impact of a time-varying confounder and its interactions with time-invariant confounders, time trends in exposures and events, restrictions, and misspecification of risk period durations on the estimators from three self-controlled methods...
January 8, 2018: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/29295637/clostridial-collagenase-ointment-and-medicinal-honey-utilization-for-pressure-ulcers-in-u-s-hospitals
#10
Jill Dreyfus, Gary Delhougne, Bobbie James, Julie Gayle, Curtis Waycaster
AIMS: Describe the utilization of clostridial collagenase ointment (CCO) and medicinal honey debridement methods in real-world inpatient and outpatient hospital settings among pressure ulcer (PU) patients and compare the frequency of healthcare re-encounters between CCO- and medicinal honey-treated patients. MATERIALS AND METHODS: De-identified hospital discharge records for patients receiving CCO or medicinal honey methods of debridement and having an ICD-9 code for PU were extracted from the U...
January 3, 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29248645/diagnostic-value-of-transluminal-attenuation-gradient-for-the-presence-of-ischemia-as-defined-by-fractional-flow-reserve-and-quantitative-positron-emission-tomography
#11
Michiel J Bom, Roel S Driessen, Wynand J Stuijfzand, Pieter G Raijmakers, Cornelis C Van Kuijk, Adriaan A Lammertsma, Albert C van Rossum, Niels van Royen, Juhani Knuuti, Maija Mäki, Koen Nieman, James K Min, Jonathon A Leipsic, Ibrahim Danad, Paul Knaapen
OBJECTIVES: The aim of this study was to investigate the incremental diagnostic value of transluminal attenuation gradient (TAG), TAG with corrected contrast opacification (TAG-CCO), and transluminal diameter gradient (TDG) over coronary computed tomography angiography (CTA)-derived diameter stenosis alone for the identification of ischemia as defined by both the invasive reference standard fractional flow reserve (FFR) and the noninvasive reference standard quantitative positron emission tomography (PET)...
December 8, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29241331/photodissociation-dynamics-of-benzaldehyde-d5-at-205-nm-the-h-atom-production-channel
#12
Sung Man Park, Sang Hyuck Yoon, Chan Ho Kwon, Hong Lae Kim
Photodissociation dynamics of benzaldehyde-d5 (C6D5CHO) at 205 nm was investigated by measuring laser-induced fluorescence spectra of fragment H atoms. From the Doppler-broadened spectra, center-of-mass translational energy release into the C6D5CO + H channel was obtained as 68.8 ± 5.8 kJ/mol with the absolute quantum yield, 0.17 ± 0.03. The observed translational energy was successfully estimated from two-dimensional potential energy surfaces along the C-H dissociation coordinate and the CCO bent angle and the out-of-plane H angle, respectively calculated at the B3LYP/cc-pVDZ level...
December 14, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29227723/interventions-to-address-sexual-problems-in-people-with-cancer-american-society-of-clinical-oncology-clinical-practice-guideline-adaptation-of-cancer-care-ontario-guideline
#13
Jeanne Carter, Christina Lacchetti, Barbara L Andersen, Debra L Barton, Sage Bolte, Shari Damast, Michael A Diefenbach, Katherine DuHamel, Judith Florendo, Patricia A Ganz, Shari Goldfarb, Sigrun Hallmeyer, David M Kushner, Julia H Rowland
Purpose The adaptation of the Cancer Care Ontario (CCO) guideline Interventions to Address Sexual Problems in People With Cancer provides recommendations to manage sexual function adverse effects that occur as a result of cancer diagnosis and/or treatment. Methods ASCO staff reviewed the guideline for developmental rigor and updated the literature search. An ASCO Expert Panel ( Table A1 ) was assembled to review the guideline content and recommendations. Results The ASCO Expert Panel determined that the recommendations from the 2016 CCO guideline are clear, thorough, and based upon the most relevant scientific evidence...
December 11, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29223850/genome-wide-analysis-of-carotenoid-cleavage-oxygenase-genes-and-their-responses-to-various-phytohormones-and-abiotic-stresses-in-apple-malus-domestica
#14
Hongfei Chen, Xiya Zuo, Hongxia Shao, Sheng Fan, Juanjuan Ma, Dong Zhang, Caiping Zhao, Xiangyan Yan, Xiaojie Liu, Mingyu Han
Carotenoid cleavage oxygenases (CCOs) are able to cleave carotenoids to produce apocarotenoids and their derivatives, which are important for plant growth and development. In this study, 21 apple CCO genes were identified and divided into six groups based on their phylogenetic relationships. We further characterized the apple CCO genes in terms of chromosomal distribution, structure and the presence of cis-elements in the promoter. We also predicted the cellular localization of the encoded proteins. An analysis of the synteny within the apple genome revealed that tandem, segmental, and whole-genome duplication events likely contributed to the expansion of the apple carotenoid oxygenase gene family...
December 5, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29215835/-matrix-metalloproteinase-1-8-9-and-the-risk-of-cardiovascular-complications-in-patients-with-chd-before-and-after-myocardial-revascularization
#15
E V Shkorik, E V Markelova, A A Silaev, B I Geltser, A A Semenikhin, L N Fedjanina
There is still a great need for detection of biomarkers for early prediction and diagnosis of cardiovascular complications (CVC) in patients with CHD. Objective: To determine the role of MMP-1, 8, 9 in the risk of CCO in patients with CHD before and after coronary artery bypass grafting (CABG). Methods. The study included 75 patients with coronary heart disease before and after myocardial revascularization by CABG, including 40 men and 35 women aged from 45 to 74 years. Patients were divided into two groups: I group - 25 patients with CVC registered after CABG (acute myocardial infarction, ischemic stroke, pulmonary thromboembolism Branch); II group - 50 patients with coronary heart disease without complications after myocardial revascularization...
April 2017: Patologicheskaia Fiziologiia i èksperimental'naia Terapiia
https://www.readbyqxmd.com/read/29164625/mechanisms-and-mitochondrial-redox-signaling-in-photobiomodulation
#16
Michael R Hamblin
Photobiomodulation (PBM) involves the use of red or near-infrared light at low power densities to produce a beneficial effect on cells or tissues. PBM therapy is used to reduce pain, inflammation, edema, and to regenerate damaged tissues such as wounds, bones and tendons. The primary site of light absorption in mammalian cells has been identified as the mitochondria, and more specifically, cytochrome c oxidase (CCO). It is hypothesized that inhibitory nitric oxide can be dissociated from CCO thus restoring electron transport and increasing mitochondrial membrane potential...
November 22, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29161977/coordinated-care-organizations-neonatal-and-infant-outcomes-in-oregon
#17
S Marie Harvey, Lisa P Oakley, Jangho Yoon, Jeff Luck
In 2012, Oregon's Medicaid program implemented a comprehensive accountable care model delivered through coordinated care organizations (CCOs). Because CCOs are expected to improve utilization of services and health outcomes, neonatal and infant outcomes may be important indicators of their impact. Estimating difference-in-differences models, we compared prepost CCO changes in outcomes (e.g., low birth weight, abnormal conditions, 5-minute Apgar score, congenital anomalies, and infant mortality) between Medicaid and non-Medicaid births among 99,924 infants born in Oregon during 2011 and 2013...
November 1, 2017: Medical Care Research and Review: MCRR
https://www.readbyqxmd.com/read/29133387/insights-into-functions-of-the-h-channel-of-cytochrome-c-oxidase-from-atomistic-molecular-dynamics-simulations
#18
Vivek Sharma, Pablo G Jambrina, Markus Kaukonen, Edina Rosta, Peter R Rich
Proton pumping A-type cytochrome c oxidase (CcO) terminates the respiratory chains of mitochondria and many bacteria. Three possible proton transfer pathways (D, K, and H channels) have been identified based on structural, functional, and mutational data. Whereas the D channel provides the route for all pumped protons in bacterial A-type CcOs, studies of bovine mitochondrial CcO have led to suggestions that its H channel instead provides this route. Here, we have studied H-channel function by performing atomistic molecular dynamics simulations on the entire, as well as core, structure of bovine CcO in a lipid-solvent environment...
November 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29106990/white-light-emitting-diode-suppresses-proliferation-and-induces-apoptosis-in-hippocampal-neuron-cells-through-mitochondrial-cytochrome-c-oxydase-mediated-igf-1-and-tnf-%C3%AE-pathways
#19
Yang Yang, Yibo Zong, Qinwei Sun, Yimin Jia, Ruqian Zhao
Light emitting diode (LED) light has been tested to treat traumatic brain injury, neural degenerative diseases and psychiatric disorders. Previous studies indicate that blue LED light affects cell proliferation and apoptosis in photosensitive cells and cancer cells. In this study, we demonstrate that white LED light exposure impaired proliferation and induced apoptosis in HeLa and HT-22 hippocampal neural cells, but not C2C12 cells. Furthermore, the mechanisms underlying the effect of white LED light exposure on HT-22 cells were elucidated...
October 26, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29101006/corneal-abnormalities-in-congenital-aniridia-congenital-central-corneal-opacity-versus-aniridia-associated-keratopathy
#20
Hyo Kyung Lee, Mee Kum Kim, Joo Youn Oh
PURPOSE: To clinically characterize and compare 2 types of corneal abnormalities in patients with congenital aniridia: (1) congenital central corneal opacity from birth (CCO) and (2) aniridia-associated keratopathy (AAK) that develops progressively with age. DESIGN: Retrospective cohort study. METHODS: Medical records of Korean patients who were diagnosed with congenital aniridia at Seoul National University Hospital between 1991 and 2016 were reviewed...
January 2018: American Journal of Ophthalmology
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