keyword
https://read.qxmd.com/read/38511614/enhancing-tomato-disease-resistance-through-endogenous-antifungal-proteins-and-introduced-nematode-targeting-dsrna-of-biocontrol-agent-bacillus-velezensis-hs-3
#1
JOURNAL ARTICLE
Juan Han, Jinchi Zhu, Shuyuan Liu, Xuehan Sun, Shunchang Wang, Guopeng Miao
BACKGROUND: As a type of biological control agents (BCAs), Bacillus velezensis possesses the efficacy of inhibiting pathogenic microorganisms, promoting plant growth, and overcoming continuous cropping obstacles (CCOs). However, there is limited reporting on the optimization of the cultivation conditions for such biocontrol agents and their role as dsRNA delivery vectors. RESULTS: In this study, a B. velezensis strain HS-3 was isolated from the root zone of tomato plants with in vitro anti-Botrytis cinerea activity...
March 21, 2024: Pest Management Science
https://read.qxmd.com/read/38506408/advances-in-testing-for-human-papillomavirus-mediated-head-and-neck-cancer
#2
JOURNAL ARTICLE
Hisham Mehanna, Laia Alemany, Christian von Buchwald
PURPOSE OF REVIEW: New evidence has recently emerged regarding the utility and benefits of dual p16INKa (p16) and Human papillomavirus (HPV) status testing when determining the diagnosis and prognosis of patients with oropharyngeal cancer. RECENT FINDINGS: HPV RNA polymerase chain reaction (PCR) is the most accurate diagnostic test. The other assays (HPV DNA PCR, HPV DNA/RNA in-situ hybridization (ISH) and p16) applied to formalin fixed tumour tissue have varying but high sensitivities and specificities...
March 20, 2024: Current Opinion in Oncology
https://read.qxmd.com/read/38504962/surgical-outcomes-in-congenital-nasolacrimal-duct-obstruction-after-probing-failure-a-one-stage-approach
#3
JOURNAL ARTICLE
Murat Oklar, Seyhan Kocabas, Mehmet Can Ozen, Ozlen Rodop Ozgur
OBJECTIVES: This study evaluates the outcomes of a one-stage obstruction-based strategy for congenital nasolacrimal duct obstruction (CNLDO) in children who have prior probing failure. The objective is to assess the success rates of probing, balloon dacrioplasty (BDP), monocanalicular intubation (MCI), and external dacryocystorhinostomy (external DCR) performed in the same anesthesia session. METHODS: A retrospective analysis included 55 eyes (45 patients, aged 12-120 months) with initial probing at another center...
2024: Beyoglu eye journal
https://read.qxmd.com/read/38472821/investigating-the-respiratory-and-energy-metabolism-mechanisms-behind-%C3%AE%C2%B5-poly-l-lysine-chitosan-coating-s-improved-preservation-effectiveness-on-tremella-fuciformis
#4
JOURNAL ARTICLE
Junzheng Sun, Yingying Wei, Longxiang Li, Baosha Tang, Yanrong Yang, Zheng Xiao, Junchen Chen, Pufu Lai
Freshly harvested Tremella fuciformis contains high water content with an unprotected outer surface and exhibits high respiration rates, which renders it prone to moisture and nutrient loss, leading to decay during storage. Our research utilized ε-poly-L-lysine (ε-PL) and chitosan as a composite coating preservative on fresh T. fuciformis . The findings revealed that the ε-PL + chitosan composite coating preservative effectively delayed the development of diseases and reduced weight loss during storage compared to the control group...
February 26, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38470062/multifunctional-sulfur-doping-in-cobalt-based-materials-for-high-energy-density-supercapacitors
#5
JOURNAL ARTICLE
Li Huang, Pengkun Wang, Hechuan Yang, Yan Wang, Wangfeng Cai
In this study, S-CCO@Co(OH)2 ('CCO' representing CuCo2 O4 /Cu2 O; 'S-'representing sulfur doping) was synthesized by hydrothermal method followed by electrodeposition. The multiple effects of S doping were studied by S doping and constructing 3D core-shell structure. S doping induced the reduction of Cu2+ and Co3+ to Cu+ and Co2+ , respectively. Also, S partially replaces O and creates oxygen vacancies, which increases a number of active sites for the redox reaction enhancing the redox reaction activity. After the electrodeposition, S-Co bond is formed between the Co(OH)2 shell and the S-CCO core, which suggests a synergistic effect between S doping and core-shell structure...
March 12, 2024: Nanotechnology
https://read.qxmd.com/read/38462921/the-impressive-efficacy-of-anti-g-protein-coupled-receptor-class-c-group-5-member-d-chimeric-antigen-receptor-t-cells-in-patients-with-relapsed-or-refractory-multiple-myeloma
#6
JOURNAL ARTICLE
https://read.qxmd.com/read/38461203/kinetic-properties-of-glucose-6-phosphate-dehydrogenase-and-inhibition-effects-of-several-metal-ions-on-enzymatic-activity-in-vitro-and-cells
#7
JOURNAL ARTICLE
Lindan Sun, Binbin Sun, Yulei Zhang, Keping Chen
Due to the non-degradable and persistent nature of metal ions in the environment, they are released into water bodies, where they accumulate in fish. In order to assess pollution in fish, the enzyme, glucose 6-phosphate dehydrogenase (G6PD), has been employed as a biomarker due to sensitivity to various ions. This study investigates the kinetic properties of the G6PD enzyme in yellow catfish (Pelteobagrus fulvidraco), and analyzes the effects of these metal ions on the G6PD enzyme activity in the ovarian cell line (CCO) of channel catfish (Ictalurus punctatus)...
March 9, 2024: Scientific Reports
https://read.qxmd.com/read/38458600/correlation-of-anterior-segment-optical-coherence-tomography-and-ultrasound-biomicroscopy-in-congenital-corneal-opacity
#8
JOURNAL ARTICLE
Sonam Yangzes, Sushmita Kaushik, Chintan Malhotra, Anchal Thakur, Amit Gupta, Arun Kumar Jain, Jitender Jinagal, Surinder Singh Pandav
PURPOSE: To investigate the correlation between swept-source anterior segment optical coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM) in congenital corneal opacity (CCO). METHODS: All children with unilateral or bilateral congenital corneal opacities who underwent examination under anesthesia (EUA) and anterior segment optical coherence tomography (AS-OCT) imaging from January 1, 2022, to December 31, 2022, were included. Main outcome measures were corneal and anterior segment evaluation and correlation of UBM and AS-OCT findings...
March 6, 2024: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://read.qxmd.com/read/38458070/tissue-damage-antioxidant-capacity-transcriptional-and-metabolic-regulation-of-red-drum-sciaenops-ocellatus-in-response-to-nanoplastics-exposure-and-subsequent-recovery
#9
JOURNAL ARTICLE
Zhicheng Sun, Linlin Zhao, Xin Peng, Meng Yan, Shaoxiong Ding, Jiachen Sun, Bin Kang
Nanoplastics are recognized as emerging contaminants that can cause severe toxicity to marine fishes. However, limited researches were focusing on the toxic effects of nanoplastics on marine fish, especially the post-exposure resilience. In this study, red drum (Sciaenops ocellatus) were exposed to 5 mg/L polystyrene nanoplastics (100 nm, PS-NPs) for a 7-day exposure experiment, and a 14-day recovery experiment that followed. The aim was to evaluate the dynamic alterations in hepatic and branchial tissue damage, hepatic antioxidant capacity, as well as hepatic transcriptional and metabolic regulation in the red drum during exposure and post-exposure to PS-NPs...
March 7, 2024: Ecotoxicology and Environmental Safety
https://read.qxmd.com/read/38457075/a-enhanced-fluorescent-probe-for-simultaneous-detection-and-discrimination-of-hydrogen-bisulfite-anions-and-glutathione
#10
JOURNAL ARTICLE
Yu Xie, Xiaoci Lv, Zhiwei Li, Yanbo Li, Heping Li
Bisulfite (HSO3 - ) and biological thiols molecules, such as glutathione (GSH), cysteine (Cys), and homocysteine (Hcy), play important roles in organisms. Developing a fluorescent probe that can simultaneously detect and distinguish HSO3 - and biological thiols is of great significance. In this study, ethyl(2E,4Z)-5-chloro-2-cyano-5-(7-(diethylamino)-2-oxo-2 H-chromen-3-yl)penta-2,4-dienoate (CCO) as a novel enhanced fluorescence probe was synthesized by integrating coumarin derivatives and ethyl cyanoacetate, which can simultaneous detection and discrimination of hydrogen bisulfite anions and glutathione...
March 8, 2024: Journal of Fluorescence
https://read.qxmd.com/read/38453659/personalized-radiation-therapy-for-glioblastoma
#11
JOURNAL ARTICLE
Waqar Haque, E Brian Butler, Bin S Teh
Glioblastoma is the most common primary brain tumor with an estimated 14,000 Americans diagnosed with this disease annually. This disease is treated with maximal surgical resection followed by adjuvant radiation therapy. Radiation therapy was initially delivered to the whole brain and with no concurrent or adjuvant systemic therapy. Advances in imaging and treatment delivery have allowed for partial brain irradiation to minimize radiation dose to normal structures, as well as sparing structures important for memory such as the hippocampus, decreasing morbidity and toxicity...
February 2024: Chinese Clinical Oncology
https://read.qxmd.com/read/38453658/perioperative-or-neoadjuvant-chemotherapy-for-locally-advanced-gastric-or-gastroesophageal-junction-cancer-from-independent-evidence-in-the-west-the-east-and-japan-to-global-collaboration
#12
REVIEW
Izuma Nakayama, Manabu Ohashi, Souya Nunobe
The survival outcome of patients with locally advanced gastric or gastroesophageal junction (G/GEJ) cancer remains unsatisfactory, and improvements in survival and recurrence remain urgent issues for clinicians worldwide. Prior to the 2000s, locally advanced G/GEJ was a different disease between the West and the East regarding diagnosis, surgery, and prognosis. However, recent advances in medical oncology have set the stage for harmonization. Herein, this review highlights clinical trials of perioperative or neoadjuvant chemotherapy conducted during the past two decades to provide insights into future directions...
February 2024: Chinese Clinical Oncology
https://read.qxmd.com/read/38453657/how-to-use-anti-pd-1-therapy-in-gastric-cancer-the-approach-in-the-united-states
#13
JOURNAL ARTICLE
David H Ilson
Gastric cancer is a leading global cause of cancer-related mortality. In the past, survival achieved in metastatic disease with chemotherapy was less than 1 year. The advent of immune checkpoint inhibitors has changed the treatment of gastric cancer. With demonstration of single agent activity for anti-programmed cell death protein 1 (anti-PD-1) agents in gastric cancer with a particularly high degree of activity in microsatellite instability (MSI) high cancers, global clinical trials added nivolumab and pembrolizumab to first line chemotherapy...
February 2024: Chinese Clinical Oncology
https://read.qxmd.com/read/38453656/chinese-physician-perception-on-the-treatment-of-chemotherapy-induced-anemia-online-cross-section-survey-study
#14
JOURNAL ARTICLE
Jian Zhang, Yiqun Du, Yanchun Meng, Xiaojun Liu, Yuxin Mu
BACKGROUND: The management of chemotherapy induced anemia (CIA) remains challenging. The potential risk and benefits in providing patient-centered care need to be balanced; the disease is multifactorial; and the major treatments including red blood cell (RBC) transfusions, erythropoiesis-stimulating agents (ESAs) and intravenous injection (i.v.)iron supplementation have a unique set of strengths and limitations. Also, most previous survey based on the patient data could not reveal the process of evaluation and decision-making for CIA treatment from a physician's perspective...
February 2024: Chinese Clinical Oncology
https://read.qxmd.com/read/38453655/bioinformatics-identification-of-characteristic-genes-of-cervical-cancer-via-an-artificial-neural-network
#15
JOURNAL ARTICLE
Liping Liu, Lingjun Huang, Li Deng, Fengjie Li, Jacopo Vannucci, Shuai Tang, Yanzhou Wang
BACKGROUND: Artificial neural networks (ANNs) have been extensively used in the field of medicine. The present hypothesis-free study sought to use an ANN to identify the characteristic genes of cervical cancer (CC). METHODS: RNA sequencing profiles were obtained from the GSE7410, GSE9750, GSE63514, and GSE52903 datasets. The differentially expressed genes (DEGs) were identified and compared between the normal and CC tissues. An ANN analysis was conducted to obtain the random-forest tree and to examine differences in gene filtering...
February 2024: Chinese Clinical Oncology
https://read.qxmd.com/read/38441194/molecular-and-nutritional-markers-in-head-and-neck-cancer
#16
JOURNAL ARTICLE
Gerard Milano, Jocelyn Gal, René-Jean Bensadoun
PURPOSE OF REVIEW: There is still a need of biomarkers in the induction and neoadjuvant settings for squamous cell carcinoma of the head and neck (SCCHN). The objective of this concise review article is to give an overview on both predictive and prognostic biomarkers potentially useful for the management of SCCHN. RECENT FINDINGS: Human papilloma virus (HPV) positivity translated by the presence of the protein indicator p16 is synonymous of favorable prognosis SCCHN...
March 1, 2024: Current Opinion in Oncology
https://read.qxmd.com/read/38441149/explore-actuate-the-future-of-personalized-medicine-in-oncology-through-emerging-technologies
#17
JOURNAL ARTICLE
Erald Babu, Subhojit Sen
PURPOSE OF REVIEW: The future of medicine is aimed to equip the physician with tools to assess the individual health of the patient for the uniqueness of the disease that separates it from the rest. The integration of omics technologies into clinical practice, reviewed here, would open new avenues for addressing the spatial and temporal heterogeneity of cancer. The rising cancer burden patiently awaits the advent of such an approach to personalized medicine for routine clinical settings...
January 22, 2024: Current Opinion in Oncology
https://read.qxmd.com/read/38441107/epigenetic-dynamics-of-aging-and-cancer-development-current-concepts-from-studies-mapping-aging-and-cancer-epigenomes
#18
REVIEW
Shilpa Bisht, Yiqing Mao, Hariharan Easwaran
PURPOSE OF REVIEW: This review emphasizes the role of epigenetic processes as incidental changes occurring during aging, which, in turn, promote the development of cancer. RECENT FINDINGS: Aging is a complex biological process associated with the progressive deterioration of normal physiological functions, making age a significant risk factor for various disorders, including cancer. The increasing longevity of the population has made cancer a global burden, as the risk of developing most cancers increases with age due to the cumulative effect of exposure to environmental carcinogens and DNA replication errors...
March 1, 2024: Current Opinion in Oncology
https://read.qxmd.com/read/38441065/can-we-yet-use-tertiary-lymphoid-structures-as-predictive-biomarkers-for-immunotherapy-response-in-melanoma
#19
JOURNAL ARTICLE
Francine Padonou, Thila Vanhulst, Mireille Langouo-Fontsa
PURPOSE OF REVIEW: In this review, we explore the potential of tertiary lymphoid structures (TLS) as predictive biomarkers in the response to immunotherapy for melanoma patients. RECENT FINDINGS: The significance of TLS as indicators predicting immunotherapy response becomes particularly pronounced. Melanoma, renowned for its aggressive characteristics, has undergone revolutionary transformations in treatment through immunotherapeutic interventions. Investigations have unveiled a compelling correlation between the presence of TLS in the melanoma tumor microenvironment and favorable responses to immunotherapy...
January 22, 2024: Current Opinion in Oncology
https://read.qxmd.com/read/38441060/altered-hormone-expression-induced-genetic-changes-leads-to-breast-cancer
#20
JOURNAL ARTICLE
Anchal Thakur, Navya Rana, Ranjit Kumar
PURPOSE OF REVIEW: Breast cancer ranks first among gynecological cancer in India. It is associated with urbanization, changes in lifestyle and obesity. Hormones also play a crucial role in the development of breast cancer. Steroid hormones play critical role in development of breast cancer. RECENT FINDING: Breast cancer is caused due to alteration in different hormone expressions leading to genetic instability. Loss or gains of functions due to genetic instability were associated with the alterations in housekeeping genes...
January 19, 2024: Current Opinion in Oncology
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