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https://www.readbyqxmd.com/read/29227723/interventions-to-address-sexual-problems-in-people-with-cancer-american-society-of-clinical-oncology-clinical-practice-guideline-adaptation-of-cancer-care-ontario-guideline
#1
Jeanne Carter, Christina Lacchetti, Barbara L Andersen, Debra L Barton, Sage Bolte, Shari Damast, Michael A Diefenbach, Katherine DuHamel, Judith Florendo, Patricia A Ganz, Shari Goldfarb, Sigrun Hallmeyer, David M Kushner, Julia H Rowland
Purpose The adaptation of the Cancer Care Ontario (CCO) guideline Interventions to Address Sexual Problems in People With Cancer provides recommendations to manage sexual function adverse effects that occur as a result of cancer diagnosis and/or treatment. Methods ASCO staff reviewed the guideline for developmental rigor and updated the literature search. An ASCO Expert Panel ( Table A1 ) was assembled to review the guideline content and recommendations. Results The ASCO Expert Panel determined that the recommendations from the 2016 CCO guideline are clear, thorough, and based upon the most relevant scientific evidence...
December 11, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29223850/genome-wide-analysis-of-carotenoid-cleavage-oxygenase-genes-and-their-responses-to-various-phytohormones-and-abiotic-stresses-in-apple-malus-domestica
#2
Hongfei Chen, Xiya Zuo, Hongxia Shao, Sheng Fan, Juanjuan Ma, Dong Zhang, Caiping Zhao, Xiangyan Yan, Xiaojie Liu, Mingyu Han
Carotenoid cleavage oxygenases (CCOs) are able to cleave carotenoids to produce apocarotenoids and their derivatives, which are important for plant growth and development. In this study, 21 apple CCO genes were identified and divided into six groups based on their phylogenetic relationships. We further characterized the apple CCO genes in terms of chromosomal distribution, structure and the presence of cis-elements in the promoter. We also predicted the cellular localization of the encoded proteins. An analysis of the synteny within the apple genome revealed that tandem, segmental, and whole-genome duplication events likely contributed to the expansion of the apple carotenoid oxygenase gene family...
December 5, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29215835/-matrix-metalloproteinase-1-8-9-and-the-risk-of-cardiovascular-complications-in-patients-with-chd-before-and-after-myocardial-revascularization
#3
E V Shkorik, E V Markelova, A A Silaev, B I Geltser, A A Semenikhin, L N Fedjanina
There is still a great need for detection of biomarkers for early prediction and diagnosis of cardiovascular complications (CVC) in patients with CHD. Objective: To determine the role of MMP-1, 8, 9 in the risk of CCO in patients with CHD before and after coronary artery bypass grafting (CABG). Methods. The study included 75 patients with coronary heart disease before and after myocardial revascularization by CABG, including 40 men and 35 women aged from 45 to 74 years. Patients were divided into two groups: I group - 25 patients with CVC registered after CABG (acute myocardial infarction, ischemic stroke, pulmonary thromboembolism Branch); II group - 50 patients with coronary heart disease without complications after myocardial revascularization...
April 2017: Patologicheskaia Fiziologiia i èksperimental'naia Terapiia
https://www.readbyqxmd.com/read/29164625/mechanisms-and-mitochondrial-redox-signaling-in-photobiomodulation
#4
Michael R Hamblin
Photobiomodulation (PBM) involves the use of red or near-infrared light at low power densities to produce a beneficial effect on cells or tissues. PBM therapy is used to reduce pain, inflammation, edema, and to regenerate damaged tissues such as wounds, bones and tendons. The primary site of light absorption in mammalian cells has been identified as the mitochondria, and more specifically, cytochrome c oxidase (CCO). It is hypothesized that inhibitory nitric oxide can be dissociated from CCO thus restoring electron transport and increasing mitochondrial membrane potential...
November 22, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29161977/coordinated-care-organizations-neonatal-and-infant-outcomes-in-oregon
#5
S Marie Harvey, Lisa P Oakley, Jangho Yoon, Jeff Luck
In 2012, Oregon's Medicaid program implemented a comprehensive accountable care model delivered through coordinated care organizations (CCOs). Because CCOs are expected to improve utilization of services and health outcomes, neonatal and infant outcomes may be important indicators of their impact. Estimating difference-in-differences models, we compared prepost CCO changes in outcomes (e.g., low birth weight, abnormal conditions, 5-minute Apgar score, congenital anomalies, and infant mortality) between Medicaid and non-Medicaid births among 99,924 infants born in Oregon during 2011 and 2013...
November 1, 2017: Medical Care Research and Review: MCRR
https://www.readbyqxmd.com/read/29133387/insights-into-functions-of-the-h-channel-of-cytochrome-c-oxidase-from-atomistic-molecular-dynamics-simulations
#6
Vivek Sharma, Pablo G Jambrina, Markus Kaukonen, Edina Rosta, Peter R Rich
Proton pumping A-type cytochrome c oxidase (CcO) terminates the respiratory chains of mitochondria and many bacteria. Three possible proton transfer pathways (D, K, and H channels) have been identified based on structural, functional, and mutational data. Whereas the D channel provides the route for all pumped protons in bacterial A-type CcOs, studies of bovine mitochondrial CcO have led to suggestions that its H channel instead provides this route. Here, we have studied H-channel function by performing atomistic molecular dynamics simulations on the entire, as well as core, structure of bovine CcO in a lipid-solvent environment...
November 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29106990/white-light-emitting-diode-suppresses-proliferation-and-induces-apoptosis-in-hippocampal-neuron-cells-through-mitochondrial-cytochrome-c-oxydase-mediated-igf-1-and-tnf-%C3%AE-pathways
#7
Yang Yang, Yibo Zong, Qinwei Sun, Yimin Jia, Ruqian Zhao
Light emitting diode (LED) light has been tested to treat traumatic brain injury, neural degenerative diseases and psychiatric disorders. Previous studies indicate that blue LED light affects cell proliferation and apoptosis in photosensitive cells and cancer cells. In this study, we demonstrate that white LED light exposure impaired proliferation and induced apoptosis in HeLa and HT-22 hippocampal neural cells, but not C2C12 cells. Furthermore, the mechanisms underlying the effect of white LED light exposure on HT-22 cells were elucidated...
October 26, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29101006/corneal-abnormalities-in-congenital-aniridia-congenital-central-corneal-opacity-versus-aniridia-associated-keratopathy
#8
Hyo Kyung Lee, Mee Kum Kim, Joo Youn Oh
PURPOSE: To clinically characterize and compare 2 types of corneal abnormalities in patients with congenital aniridia: (1) congenital central corneal opacity from birth (CCO) and (2) aniridia-associated keratopathy (AAK) that develops progressively with age. DESIGN: Retrospective cohort study. METHODS: Medical records of Korean patients who were diagnosed with congenital aniridia at Seoul National University Hospital between 1991 and 2016 were reviewed...
October 31, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29067359/the-reductive-phase-of-rhodobacter-sphaeroides-cytochrome-c-oxidase-disentangled-by-co-ligation
#9
Hendrik Mohrmann, Jovan Dragelj, Federico Baserga, Ernst-Walter Knapp, Sven T Stripp, Joachim Heberle
Cytochrome c oxidase (CcO) is a membrane protein of the respiratory chain that catalytically reduces molecular oxygen (O2) to water while translocating protons across the membrane. The enzyme hosts two copper and two heme iron moieties (heme a/heme a3). The atomic details of the sequential steps that go along with this redox-driven proton translocation are a matter of debate. Particularly for the reductive phase of CcO that precedes oxygen binding experimental data are scarce. Here, we use CcO under anaerobic conditions where carbon monoxide (CO) is bound to heme a3 which in tandem with CuB forms the binuclear center (BNC)...
October 25, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29057564/the-effect-of-fetal-hemodynamics-on-fetal-growth-in-single-ventricle-and-transposition-of-the-great-arteries
#10
Tarek Alsaied, Stephanie Tseng, Eileen King, Eunice Hahn, Allison Divanovic, Mounira Habli, James Cnota
INTRODUCTION: As birth weight is a critical predictor of neonatal congenital heart defect (CHD) outcomes, the common problem of poor fetal growth in this population is clinically important but not well understood. The impact of fetal hemodynamics on fetal growth and birth weight in CHD has not been assessed. Combined cardiac output (CCO) has been used to evaluate patients with structurally normal heart but rarely in CHD. Middle cerebral artery and umbilical artery pulsatility indices (PIs) have been used to evaluate the relative distribution of circulation in patients with CHD...
October 23, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29039063/evaluation-of-the-use-of-the-fourth-version-flotrac-system-in-cardiac-output-measurement-before-and-after-cardiopulmonary-bypass
#11
Sheng-Yi Lin, An-Hsun Chou, Yung-Fong Tsai, Su-Wei Chang, Min-Wen Yang, Pei-Chi Ting, Chun-Yu Chen
The FloTrac system is a system for cardiac output (CO) measurement that is less invasive than the pulmonary artery catheter (PAC). The purposes of this study were to (1) compare the level of agreement and trending abilities of CO values measured using the fourth version of the FloTrac system (CCO-FloTrac) and PAC-originated continuous thermodilution (CCO-PAC) and (2) analyze the inadequate CO-discriminating ability of the FloTrac system before and after cardiopulmonary bypass (CPB). Fifty patients were included...
October 16, 2017: Journal of Clinical Monitoring and Computing
https://www.readbyqxmd.com/read/29035643/role-of-bone-modifying-agents-in-metastatic-breast-cancer-an-american-society-of-clinical-oncology-cancer-care-ontario-focused-guideline-update
#12
Catherine Van Poznak, Mark R Somerfield, William E Barlow, J Sybil Biermann, Linda D Bosserman, Mark J Clemons, Sukhbinder K Dhesy-Thind, Melissa S Dillmon, Andrea Eisen, Elizabeth S Frank, Reshma Jagsi, Rachel Jimenez, Richard L Theriault, Theodore A Vandenberg, Gary C Yee, Beverly Moy
Purpose To update, in collaboration with Cancer Care Ontario (CCO), key recommendations of the American Society of Clinical Oncology (ASCO) guideline on the role of bone-modifying agents (BMAs) in metastatic breast cancer. This focused update addressed the new data on intervals between dosing and the role of BMAs in control of bone pain. Methods A joint ASCO-CCO Update Committee conducted targeted systematic literature reviews to identify relevant studies. Results The Update Committee reviewed three phase III noninferiority trials of dosing intervals, one systematic review and meta-analysis of studies of de-escalation of BMAs, and two randomized trials of BMAs in control of pain secondary to bone metastases...
October 16, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28992020/rapid-communication-dietary-selenium-improves-skeletal-muscle-mitochondrial-biogenesis-in-young-equine-athletes
#13
S H White, S Wohlgemuth, C Li, L K Warren
Exercise is known to promote mitochondrial biogenesis in skeletal muscle as well as enhance mitochondrial function and efficiency in human and rodent models. These adaptations help to decrease exercise-associated production of reactive oxygen species, which can negatively affect health and performance if antioxidant mechanisms are overwhelmed. Little is known about the adaptations of mitochondria in response to exercise training in the growing horse or if supplementation with a dietary antioxidant can improve mitochondrial function...
September 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28988874/regulation-of-mammalian-13-subunit-cytochrome-c-oxidase-and-binding-of-other-proteins-role-of-ndufa4
#14
REVIEW
Bernhard Kadenbach
Cytochrome c oxidase (CcO) is the final oxygen accepting enzyme complex (complex IV) of the mitochondrial respiratory chain. In contrast to the other complexes (I, II, and III), CcO is highly regulated via isoforms for six of its ten nuclear-coded subunits, which are differentially expressed in species, tissues, developmental stages, and cellular oxygen concentrations. Recent publications have claimed that NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4 (NDUFA4), originally identified as subunit of complex I, represents a 14th subunit of CcO...
November 2017: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/28973914/cavity-hydration-dynamics-in-cytochrome-c-oxidase-and-functional-implications
#15
Chang Yun Son, Arun Yethiraj, Qiang Cui
Cytochrome c oxidase (CcO) is a transmembrane protein that uses the free energy of O2 reduction to generate the proton concentration gradient across the membrane. The regulation of competitive proton transfer pathways has been established to be essential to the vectorial transport efficiency of CcO, yet the underlying mechanism at the molecular level remains lacking. Recent studies have highlighted the potential importance of hydration-level change in an internal cavity that connects the proton entrance channel, the site of O2 reduction, and the putative proton exit route...
October 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28970047/transcriptomic-analysis-reveals-differentially-expressed-genes-and-a-unique-apoptosis-pathway-in-channel-catfish-ovary-cells-after-infection-with-the-channel-catfish-virus
#16
Farman Ullah Dawar, Xianqin Hu, Lijuan Zhao, Xingxing Dong, Yang Xiong, Meng Zhou, Rishen Liang, V Sarath Babu, Jun Li, Jie Mei, Li Lin
The channel catfish virus (CCV) can cause lethal hemorrhagic infection in juvenile channel catfish, thereby resulting in a huge economic loss to the fish industry. The genome of the CCV has been fully sequenced, and its prevalence is well documented. However, less is known about the molecular mechanisms and pathogenesis of the CCV. Herein, the channel catfish ovary cells (CCO) were infected with CCV and their transcriptomic sketches were analyzed using an RNA sequencing technique. In total, 72,686,438 clean reads were obtained from 73,231,128 sequence reads, which were further grouped into 747,168 contigs...
September 29, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28949271/pressure-passivity-of-cerebral-mitochondrial-metabolism-is-associated-with-poor-outcome-following-perinatal-hypoxic-ischemic-brain-injury
#17
Subhabrata Mitra, Gemma Bale, David Highton, Roxanna Gunny, Cristina Uria-Avellanal, Alan Bainbridge, Magdalena Sokolska, David Price, Angela Huertas-Ceballos, Giles S Kendall, Judith Meek, Ilias Tachtsidis, Nicola J Robertson
Hypoxic ischemic encephalopathy (HIE) leads to significant morbidity and mortality. Impaired autoregulation after hypoxia-ischaemia has been suggested to contribute further to injury. Thalamic lactate/N-Acetylasperate (Lac/NAA) peak area ratio of > 0.3 on proton ((1)H) magnetic resonance spectroscopy (MRS) is associated with poor neurodevelopment outcome following HIE. Cytochrome-c-oxidase (CCO) plays a central role in mitochondrial oxidative metabolism and ATP synthesis. Using a novel broadband NIRS system, we investigated the impact of pressure passivity of cerebral metabolism (CCO), oxygenation (haemoglobin difference (HbD)) and cerebral blood volume (total haemoglobin (HbT)) in 23 term infants following HIE during therapeutic hypothermia (HT)...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28946353/application-of-propyl-gallate-alleviates-pericarp-browning-in-harvested-longan-fruit-by-modulating-metabolisms-of-respiration-and-energy
#18
Yifen Lin, Yixiong Lin, Hetong Lin, Yihui Chen, Hui Wang, John Shi
Effects of propyl gallate on metabolisms of respiration and energy of harvested 'Fuyan' longans and its relationship to pericarp browning were investigated. Compared to control longans, propyl gallate could reduce ascorbic acid oxidase (AAO) activity, lower cytochrome C oxidase (CCO) activity during early-storage and mid-storage, increase NADK activity, elevate contents of NADP and NADPH, decrease contents of NAD and NADH, in addition, lower the decreases of ATP content and energy charge (E.C.), increase activities of mitochondrial H(+)-ATPase, Ca(2+)-ATPase and Mg(2+)-ATPase during early-storage and mid-storage...
February 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28940516/analysis-of-clonal-expansions-through-the-normal-and-premalignant-human-breast-epithelium-reveals-the-presence-of-luminal-stem-cells
#19
Biancastella Cereser, Marnix Jansen, Emily Austin, George Elia, Taneisha McFarlane, Carolien Hm van Deurzen, Anieta M Sieuwerts, Maria G Daidone, Paul J Tadrous, Nicholas A Wright, Louise Jones, Stuart Ac McDonald
It is widely accepted that the cell of origin of breast cancer is the adult mammary epithelial stem cell, however demonstrating the presence and location of tissue stem cells in the human breast has proved difficult. Furthermore, we do not know the clonal architecture of the normal and premalignant mammary epithelium or its cellular hierarchy. Here we use deficiency in the mitochondrial enzyme cytochrome c oxidase (CCO), typically caused by somatic mutations in the mitochondrial genome, as a means to perform lineage tracing in the human mammary epithelium...
September 22, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28913995/intraoperatively-observed-lacrimal-obstructive-features-and-surgical-outcomes-in-external-dacryocystorhinostomy
#20
Min Joung Lee, Sang In Khwarg, In Hyuk Kim, Jeong Hoon Choi, Youn Joo Choi, Namju Kim, Ho Kyung Choung
PURPOSE: To analyze the features of lacrimal drainage system obstruction confirmed during external dacryocystorhinostomy surgeries and report the surgical outcomes. METHODS: We reviewed the medical records of a total of 769 cases who underwent external dacryocystorhinostomy for primary lacrimal drainage obstruction between 2005 and 2014. Data about detailed location and extent of obstruction were collected intraoperatively. The sites of obstruction were classified into nasolacrimal duct obstruction (NLDO), common canalicular obstruction (CCO), and canalicular obstruction...
October 2017: Korean Journal of Ophthalmology: KJO
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