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https://www.readbyqxmd.com/read/29775114/oxygen-dependency-of-mitochondrial-metabolism-indicates-outcome-of-newborn-brain-injury
#1
Gemma Bale, Subhabrata Mitra, Isabel de Roever, Magdalena Sokolska, David Price, Alan Bainbridge, Roxana Gunny, Cristina Uria-Avellanal, Giles S Kendall, Judith Meek, Nicola J Robertson, Ilias Tachtsidis
There is a need for a method of real-time assessment of brain metabolism during neonatal hypoxic-ischaemic encephalopathy (HIE). We have used broadband near-infrared spectroscopy (NIRS) to monitor cerebral oxygenation and metabolic changes in 50 neonates with HIE undergoing therapeutic hypothermia treatment. In 24 neonates, 54 episodes of spontaneous decreases in peripheral oxygen saturation (desaturations) were recorded between 6 and 81 h after birth. We observed differences in the cerebral metabolic responses to these episodes that were related to the predicted outcome of the injury, as determined by subsequent magnetic resonance spectroscopy derived lactate/N-acetyl-aspartate...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29754987/a-statewide-effort-to-reduce-high-dose-opioid-prescribing-through-coordinated-care-organizations
#2
Daniel M Hartung, Lindsey Alley, Gillian Leichtling, P Todd Korthuis, Christi Hildebran
BACKGROUND: Oregon's Medicaid program is delivered through 16 Coordinated Care Organizations (CCOs) participating in a statewide performance improvement program to reduce high-dose opioid prescribing. CCOs were allowed flexibility to develop their own dose targets and any policies, trainings, guidelines, and/or materials to meet these targets. In this study, we characterize CCO strategies to reduce high-dose opioid prescribing across the 16 CCOs. METHODS: We reviewed relevant CCO documents and conducted semi-structured interviews with CCO administrators to acquire opioid-related policies, practices, timelines and contextual factors...
May 1, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29752896/wavelength-dependence-of-vasodilation-and-no-release-from-s-nitrosothiols-and-dinitrosyl-iron-complexes-by-far-red-near-infrared-light
#3
Agnes Keszler, Brian Lindemer, Neil Hogg, Dorothee Weihrauch, Nicole L Lohr
Far red/near infrared (R/NIR) energy is a novel therapy, but its mechanism of action is poorly characterized. Cytochrome c oxidase (Cco) of the mitochondrial electron transport chain is considered the primary photoacceptor for R/NIR to photolyze a putative heme nitrosyl in Cco to liberate free nitric oxide (NO). We previously observed R/NIR light directly liberates NO from nitrosylated hemoglobin and myoglobin, and recently suggested S-nitrosothiols (RSNO) and dinitrosyl iron complexes (DNIC) may be primary sources of R/NIR-mediated NO...
May 9, 2018: Archives of Biochemistry and Biophysics
https://www.readbyqxmd.com/read/29739833/central-nervous-shutdown-underlies-acute-cold-tolerance-in-tropical-and-temperate-drosophila-species
#4
Mads Kuhlmann Andersen, Nikolaj Johannes Skole Jensen, R Meldrum Robertson, Johannes Overgaard
When cooled, insects first lose their ability to perform coordinated movements (CTmin ) after which they enter chill coma (chill coma onset, CCO). Both these behaviours are popular measures of cold tolerance that correlate remarkably well with species distribution. To identify and understand the neuromuscular impairment that causes CTmin and CCO we used inter- and intraspecific model systems of Drosophila species that have varying cold tolerance as a consequence of adaptation or cold acclimation. Our results demonstrate that CTmin and CCO correlate strongly with a spreading depolarization (SD) within the central nervous system (CNS)...
May 8, 2018: Journal of Experimental Biology
https://www.readbyqxmd.com/read/29609494/oxidative-damage-mediated-inos-and-ucp-2-upregulation-in-rat-brain-after-sub-acute-cyanide-exposure-dose-and-time-dependent-effects
#5
Rahul Bhattacharya, Poonam Singh, Jebin Jacob John, Niranjan L Gujar
Cyanide-induced chemical hypoxia is responsible for pronounced oxidative damage in the central nervous system. The disruption of mitochondrial oxidative metabolism has been associated with upregulation of uncoupling proteins (UCPs). The present study addresses the dose- and time-dependent effect of sub-acute cyanide exposure on various non-enzymatic and enzymatic oxidative stress markers and their correlation with inducible-nitric oxide synthase (iNOS) and uncoupling protein-2 (UCP-2) expression. Animals received (oral) triple distilled water (vehicle control), 0...
April 3, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29540304/polyethylene-glycol-promotes-autoxidation-of-cytochrome-c
#6
Wataru Sato, Takeshi Uchida, Tomohide Saio, Koichiro Ishimori
Cytochrome c (Cyt c) was rapidly oxidized by molecular oxygen in the presence, but not absence of PEG. The redox potential of heme c was determined by the potentiometric titration to be +236 ± 3 mV in the absence of PEG, which was negatively shifted to +200 ± 4 mV in the presence of PEG. The underlying the rapid oxidation was explored by examining the structural changes in Cyt c in the presence of PEG using UV-visible absorption, circular dichroism, resonance Raman, and fluorescence spectroscopies...
March 11, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29526773/altered-brain-functional-connectivity-and-behaviour-in-a-mouse-model-of-maternal-alcohol-binge-drinking
#7
Lídia Cantacorps, Héctor González-Pardo, Jorge L Arias, Olga Valverde, Nélida M Conejo
Prenatal and perinatal alcohol exposure caused by maternal alcohol intake during gestation and lactation periods can have long-lasting detrimental effects on the brain development and behaviour of offspring. Children diagnosed with Foetal Alcohol Spectrum Disorders (FASD) display a wide range of cognitive, emotional and motor deficits, together with characteristic morphological abnormalities. Maternal alcohol binge drinking is particularly harmful for foetal and early postnatal brain development, as it involves exposure to high levels of alcohol over short periods of time...
June 8, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29520539/temperament-in-child-and-adolescent-offspring-of-patients-with-schizophrenia-and-bipolar-disorder
#8
Covadonga M Díaz-Caneja, Mª Goretti Morón-Nozaleda, Raquel P Vicente-Moreno, Elisa Rodríguez-Toscano, Laura Pina-Camacho, Elena de la Serna, Gisela Sugranyes, Inmaculada Baeza, Soledad Romero, Vanessa Sánchez-Gistau, Josefina Castro-Fornieles, Carmen Moreno, Dolores Moreno
Shared vulnerability in offspring of individuals with schizophrenia (SzO) and bipolar disorder (BpO) might manifest early during development through common temperament traits. Temperament dimensions in child and adolescent BpO (N = 80), SzO (N = 34) and the offspring of community controls (CcO) (N = 101) were assessed using the Revised Dimensions of Temperament Survey. The association between temperament dimensions and lifetime psychopathology (including threshold and subthreshold DSM-IV-TR diagnoses) and current socio-academic adjustment was assessed using logistic regression...
March 8, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29520532/factors-influencing-survival-among-patients-with-her2-positive-metastatic-breast-cancer-treated-with-trastuzumab
#9
P S Blanchette, D N Desautels, G R Pond, J M S Bartlett, S Nofech-Mozes, M J Yaffe, K I Pritchard
PURPOSE: We have limited capability to predict survival among patients treated for metastatic HER2-positive breast cancer. Further research is warranted to identify significant prognostic and predictive factors. METHODS: We identified all HER2-positive metastatic breast cancer patients receiving trastuzumab at the Sunnybrook Odette Cancer Centre (SOCC) from 1999 to 2013 through the Cancer Care Ontario (CCO) Registry (n = 256) and selected patients with available pathology reports (n = 154)...
March 8, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29505371/oregon-s-emphasis-on-equity-shows-signs-of-early-success-for-black-and-american-indian-medicaid-enrollees
#10
K John McConnell, Christina J Charlesworth, Thomas H A Meath, Rani M George, Hyunjee Kim
In 2012 Oregon transformed its Medicaid program, providing coverage through sixteen coordinated care organizations (CCOs). The state identified the elimination of health disparities as a priority for the CCOs, implementing a multipronged approach that included strategic planning, community health workers, and Regional Health Equity Coalitions. We used claims-based measures of utilization, access, and quality to assess baseline disparities and test for changes over time. Prior to the CCO intervention there were significant white-black and white-American Indian/Alaska Native disparities in utilization measures and white-black disparities in quality measures...
March 2018: Health Affairs
https://www.readbyqxmd.com/read/29454588/diagnostic-performance-of-two-corrected-transluminal-attenuation-gradient-metrics-in-coronary-ct-angiography-for-the-evaluation-of-significant-in-stent-restenosis-by-dual-source-ct-a-validation-study-with-invasive-coronary-angiography
#11
D Wen, J Li, H Zhao, J Li, M Zheng
AIM: To determine the diagnostic potential of transluminal attenuation gradients (TAG) with exclusion of stented coronary segments (TAG-ExS) and TAG-corrected contrast opacification (CCO) excluding stented coronary segments (TAG-CCO-ExS) for the assessment of in-stent restenosis (ISR). MATERIALS AND METHODS: TAG-ExS and TAG-CCO-ExS were calculated in 93 coronary arteries with 190 stents. The diagnostic performances and the incremental values of the two metrics to coronary computed tomography angiography (CCTA) were analysed and compared...
June 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29435610/hydrogen-bonded-network-and-water-dynamics-in-the-d-channel-of-cytochrome-c-oxidase
#12
Tahereh Ghane, Rene F Gorriz, Sandro Wrzalek, Senta Volkenandt, Ferand Dalatieh, Marco Reidelbach, Petra Imhof
Proton transfer in cytochrome c oxidase (CcO) from the cellular inside to the binuclear redox centre as well as proton pumping through the membrane takes place through proton entrance via two distinct pathways, the D- and K-channel. Both channels show a dependence of their hydration level on the protonation states of their key residues, K362 for the K-channel, and E286 or D132 for the D-channel. In the oxidative half of CcO's catalytic cycle the D-channel is the proton-conducting path. For this channel, an interplay of protonation state of the D-channel residues with the water and hydrogen-bond dynamics has been observed in molecular dynamics simulations of the CcO protein, embedded in a lipid bi-layer, modelled in different protonation states...
February 12, 2018: Journal of Membrane Biology
https://www.readbyqxmd.com/read/29429331/investigation-of-lipid-metabolism-by-a-new-structured-lipid-with-medium-and-long-chain-triacylglycerols-from-cinnamomum-camphora-seed-oil-in-healthy-c57bl-6j-mice
#13
Jiang-Ning Hu, Jin-Rong Shen, Chao-Yue Xiong, Xue-Mei Zhu, Ze-Yuan Deng
In the present study, a new structured lipid with medium- and long-chain triacylglycerols (MLCTs) was synthesized from camellia oil (CO) and Cinnamomum camphora seed oil (CCSO) by enzymatic interesterification. Meanwhile, the antiobesity effects of structured lipid were investigated through observing the changes of enzymes related to lipid mobilization in healthy C57BL/6J mice. Results showed that after synthesis, the major triacylgeride (TAG) species of intesterificated product changed to LaCC/CLaC (12.6 ± 0...
February 28, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29428329/three-year-clinical-results-of-carotid-artery-stenting-in-treating-patients-with-contralateral-carotid-artery-occlusion
#14
Jianming Guo, Lianrui Guo, Zhu Tong, Zhonggao Wang, Alan Dardik, Yongquan Gu
BACKGROUND: Patients presenting a carotid stenosis and contralateral carotid occlusion (CCO) have been historically considered at high risk of carotid surgical treatment, and there are few data regarding short-term recovery after stenting therapy in patients with CCO. The aim of this study is to evaluate the short-term recovery and safety of stenting for patients with CCO and different subgroup population. METHODS: We retrospectively reviewed the records of consecutive patients with CCO who were treated with stenting endovascular methods between 2008 and 2014...
May 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29408380/parent-child-feeding-practices-in-a-developing-country-findings-from-the-family-diet-study
#15
Wai Yew Yang, Tracy Burrows, Lesley MacDonald-Wicks, Lauren T Williams, Clare E Collins, Winnie Siew Swee Chee
BACKGROUND AND AIMS: Given the increasing prevalence of childhood obesity in Malaysia, examination of family environmental factors is warranted. Reviews from developed countries report inconsistent findings on the relationship between parental-child feeding practices and child weight-related health outcomes. The current study aimed to examine parent-child feeding practices by familial-child characteristics in Malaysia. MATERIALS AND METHOD: The Family Diet Study was conducted with urban Malay families and included a child aged 8-12 years and their main carer(s)...
June 1, 2018: Appetite
https://www.readbyqxmd.com/read/29400318/structure-of-bovine-cytochrome-c-oxidase-in-the-ligand-free-reduced-state-at-neutral-ph
#16
Fangjia Luo, Kyoko Shinzawa-Itoh, Kaede Hagimoto, Atsuhiro Shimada, Satoru Shimada, Eiki Yamashita, Shinya Yoshikawa, Tomitake Tsukihara
Cytochrome c oxidase (CcO), the terminal oxidase in cellular respiration, couples proton pumping to O2 reduction. Mammalian CcO resides in the inner mitochondrial membrane. Previously, a model of H-pathway proton pumping was proposed based on various CcO crystal structures. However, all previously determined structures were solved using crystals obtained at pH 5.7, which differs from the environmental pH of CcO in the inner membrane. The structures of fully oxidized and ligand-free reduced CcO at pH 7.3 have now been determined...
February 1, 2018: Acta Crystallographica. Section F, Structural Biology Communications
https://www.readbyqxmd.com/read/29396798/the-involvement-of-cytochrome-c-oxidase-in-mitochondrial-fusion-in-primary-cultures-of-neonatal-rat-cardiomyocytes
#17
Wen Yin, Rui Li, Xiaorong Feng, Y James Kang
Cytochrome c oxidase (CCO) is a copper-dependent enzyme of mitochondrial respiratory chain. In pressure overload-induced cardiac hypertrophy, copper level and CCO activity are both depressed, along with disturbance in mitochondrial fusion and fission dynamics. Copper repletion leads to recovery of CCO activity and normalized mitochondrial dynamics. The present study was undertaken to define the link between CCO activity and mitochondrial dynamic changes. Primary cultures of neonatal rat cardiomyocytes were treated with phenylephrine to induce cell hypertrophy...
February 2, 2018: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29350917/oxygen-activation-and-energy-conservation-by-cytochrome-c-oxidase
#18
Mårten Wikström, Klaas Krab, Vivek Sharma
This review focuses on the type A cytochrome c oxidases (C cO), which are found in all mitochondria and also in several aerobic bacteria. C cO catalyzes the respiratory reduction of dioxygen (O2 ) to water by an intriguing mechanism, the details of which are fairly well understood today as a result of research for over four decades. Perhaps even more intriguingly, the membrane-bound C cO couples the O2 reduction chemistry to translocation of protons across the membrane, thus contributing to generation of the electrochemical proton gradient that is used to drive the synthesis of ATP as catalyzed by the rotary ATP synthase in the same membrane...
March 14, 2018: Chemical Reviews
https://www.readbyqxmd.com/read/29315517/role-of-respiratory-terminal-oxidases-in-the-extracellular-electron-transfer-ability-of-cyanobacteria
#19
Narendran Sekar, Jian Wang, Yan Zhou, Yi Fang, Yajun Yan, Ramaraja P Ramasamy
Cyanobacteria are used as anode catalysts in photo-bioelectrochemical cells to generate electricity in a sustainable, economic, and environmental friendly manner using only water and sunlight. Though cyanobacteria (CB) possess unique advantage for solar energy conversion by virtue of its robust photosynthesis, they cannot efficiently perform extracellular electron transfer (EET). The reasons being, unlike dissimilatory metal reducing bacteria (that are usually exploited in microbial fuel cells to generate electricity), (1) CB do not possess any special features on their outer membrane to carry out EET and, (2) the electrons generated in photosynthetic electron transport chain are channeled into competing respiratory pathways rather than to the anode...
May 2018: Biotechnology and Bioengineering
https://www.readbyqxmd.com/read/29310575/a-comparison-of-estimators-from-self-controlled-case-series-case-crossover-design-and-sequence-symmetry-analysis-for-pharmacoepidemiological-studies
#20
Yoshinori Takeuchi, Tomohiro Shinozaki, Yutaka Matsuyama
BACKGROUND: Despite the frequent use of self-controlled methods in pharmacoepidemiological studies, the factors that may bias the estimates from these methods have not been adequately compared in real-world settings. Here, we comparatively examined the impact of a time-varying confounder and its interactions with time-invariant confounders, time trends in exposures and events, restrictions, and misspecification of risk period durations on the estimators from three self-controlled methods...
January 8, 2018: BMC Medical Research Methodology
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